CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_008554	Syntrophobacter fumaroxidans MPOB, complete sequence	21 crisprs	Cas9_archaeal,csa3,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,csx20,csx1,PrimPol,cas1,cas2,cas3,RT,DinG,WYL,cas8e,cse2gr11,cas7,cas6e	1	47	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_008554_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_1

288385-288477

Orphan

Consensus_repeat	Method
CCCCGGGTCCAGACTGACGAGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_1

>merge|NC_008554|1|288385-288477|CRISPRCasFinder
CCCCGGGTCCAGACTGACGAGCGGGTCCTTTCGGACGGAAGCGAAAGCCCGCGCCTTGGGGGGGCCAAACCCCGGGTTCAGACTGACGAGCGG

>NC_008554|1|1|288385-288477|CRISPRCasFinder
CCCCGGGTCCAGACTGACGAGCGG	GTCCTTTCGGACGGAAGCGAAAGCCCGCGCCTTGGGGGGGCCAAA
CCCCGGGTTCAGACTGACGAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011697112.1\|278821_279436_+\|phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|163560
NC_008554.1\|WP_049766451.1\|300092_300737_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NC_008554.1\|WP_083763896.1\|294562_299335_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NC_008554.1\|WP_041439543.1\|287262_288366_+\|DUF362-domain-containing-protein	unknown	unknown	gnl\|CDD\|224917
NC_008554.1\|WP_011697116.1\|282741_284157_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NC_008554.1\|WP_011697123.1\|290424_292389_-\|peptide-transporter	unknown	unknown	gnl\|CDD\|367370
NC_008554.1\|WP_011697126.1\|299331_300066_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_008554.1\|WP_011697130.1\|304390_306253_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697124.1\|292504_294484_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697117.1\|284216_285914_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NC_008554.1\|WP_011697111.1\|277619_278678_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_041439546.1\|289786_289954_-\|DUF1328-domain-containing-protein	unknown	unknown	gnl\|CDD\|227774
NC_008554.1\|WP_011697119.1\|286841_287123_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225893
NC_008554.1\|WP_011697121.1\|288480_289383_-\|phosphodiester-glycosidase-family-protein	unknown	unknown	gnl\|CDD\|378342
NC_008554.1\|WP_011697118.1\|286139_286481_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226447
NC_008554.1\|WP_150109602.1\|281347_282484_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_008554.1\|WP_011697129.1\|303177_304347_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NC_008554.1\|WP_011697128.1\|301177_302302_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227017
NC_008554.1\|WP_083763894.1\|279797_280568_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226098
NC_008554.1\|WP_049766251.1\|280560_281226_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011697112.1\|278821_279436_+\|phosphoglycerate-mutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	1.44218e-51
NC_008554.1\|WP_049766451.1\|300092_300737_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	1.53712e-18
NC_008554.1\|WP_083763896.1\|294562_299335_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	6.36863e-10
NC_008554.1\|WP_041439543.1\|287262_288366_+\|DUF362-domain-containing-protein	gnl\|CDD\|224917	COG2006, COG2006, Uncharacterized conserved protein [Function unknown].	8.55182e-72
NC_008554.1\|WP_011697116.1\|282741_284157_+\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	2.45631e-133
NC_008554.1\|WP_011697123.1\|290424_292389_-\|peptide-transporter	gnl\|CDD\|367370	pfam03169, OPT, OPT oligopeptide transporter protein. The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.	0.000214312
NC_008554.1\|WP_011697128.1\|301177_302302_-\|hypothetical-protein	gnl\|CDD\|227017	COG4671, COG4671, Predicted glycosyl transferase [General function prediction only].	1.34655e-81
NC_008554.1\|WP_011697126.1\|299331_300066_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.45574e-109
NC_008554.1\|WP_011697117.1\|284216_285914_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	5.17115e-122
NC_008554.1\|WP_041439546.1\|289786_289954_-\|DUF1328-domain-containing-protein	gnl\|CDD\|227774	COG5487, COG5487, Small integral membrane protein [Function unknown].	1.76539e-05
NC_008554.1\|WP_011697119.1\|286841_287123_+\|transcriptional-regulator	gnl\|CDD\|225893	COG3357, COG3357, Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription].	2.05561e-18
NC_008554.1\|WP_011697121.1\|288480_289383_-\|phosphodiester-glycosidase-family-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	4.76604e-17
NC_008554.1\|WP_011697118.1\|286139_286481_-\|hypothetical-protein	gnl\|CDD\|226447	COG3937, COG3937, Uncharacterized conserved protein [Function unknown].	2.48157e-11
NC_008554.1\|WP_150109602.1\|281347_282484_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.43355e-54
NC_008554.1\|WP_011697129.1\|303177_304347_-\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	1.06411e-17
NC_008554.1\|WP_083763894.1\|279797_280568_+\|hypothetical-protein	gnl\|CDD\|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	3.80858e-49
NC_008554.1\|WP_049766251.1\|280560_281226_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.60449e-24

>NC_008554.1|WP_041439543.1|287262_288366_+|DUF362-domain-containing-protein
MTKVILERASYEYGSLRTHIFSMLESCGISVGEGRKVLLKPNLLAPASPEKAMLTHPLVVRVAAEYVLEKGGVVQLSDSPAMGGFDKVLRESGIKDALAGLPVEFKEFRDSVPVEVGPPFNRLELAADALDADVLINLPKLKTHGQMLLTLGVKNLFGCVVGLRKPQWHLRTGVDREMFAALLVTIYRKLMPSVTILDGILAMEGNGPGRGGKPKELGLLMASTDAIAVDMTVCEMLGLPADALFTNAAAARAGIAPARIDVRGDKFRIQGFQLPKMTPLVFGPKFTHKLMRKFLVQRPQADPLLCKACGDCRKYCPAGAITQAGSKIEFDYDRCIRCYCCIEVCPHGALRAVEPYPGRLFNRIIRR
>NC_008554.1|WP_011697119.1|286841_287123_+|transcriptional-regulator
MKTVRQEMIEELVKGEQTALGLSKSLRRSEKDIYEHLEHISRSLTSQGKRLTIVPARCLECGYLFESRNRFTSPGRCPRCKGTHIEDPRYRIE
>NC_008554.1|WP_011697118.1|286139_286481_-|hypothetical-protein
MFELIRKSFLAGLGVVVLTKEKVQEFTRMLVEEGRLSTEEADKLADDLVKSGQRQWDEINAKTQETVKKLVNAVDFVRRKEFQDLTARVEALEQRLGMTADTKEADEPKAEGS
>NC_008554.1|WP_011697117.1|284216_285914_+|AarF/ABC1/UbiB-kinase-family-protein
MTISLKPEHLKRYKDLVWLLVKYGRSDIISQAGLDTIIPEQELPSPVVSPKVDELPHDLEKLGPTYIKLGQFLSTRSDLLPPQYLEALSRLQDSAEQFPFEKVEEILILELGQRTTREFASFDPVPLAAASLAQVHRAVLRDGRLVAVKVQRPGIRRRVIQDLEAFDELAEFLERHLSLAKRFMLQATVAEFRKAVMRELDFRQEAQNLIVLARNLRDYDLIVVPTPIEEYSSTRVLTMDYLEGRKLTTIGFTEPLAAERSKLADHLFRAYLQQIFLDGFYHADPHPGNLYLTGDGRLALVDLGMVARISGASQQKLLRMMVAIGEGRSEEAAEFAVELGEKTLLFDEKRFRKEISDLIIRYQRATIKEIQAGKILLELLKAAGNSGIRFPSEFTMLGKTLMNLDAIGRILDPSYDPNAALRRYSGQLLRQRIRKTVSAANVFEMLIDSQDFLRLLPKRIGKIIDLVAENRVRMQANVIDEKYLMTGLQKIANRLTLGLILAALIVGAALMMRIRTEFTLFGYPGIPILFFLVAVIGSLALVFSIVIHDERVRRMKRPRDEDGEK
>NC_008554.1|WP_011697116.1|282741_284157_+|cardiolipin-synthase
MDGFLTAAQWIIPIAMVPVAAHGHSPVGALAWLLFIFFKPWAGLILYFLFGTNLVMRRLTKSYCQRLREVRSFSDLAIMEPHVFGLSSEQTEHRLAKMTERLACMPILQGNEVEFIDNGFAVIDRMIADIGKARDHVHLLFYIFNDDEVGRRVAEALAGAAARGVPCRVVVDAFGSRSLNGSLGEWMVKRGIDFQTLMSINPFRRHLTRLDLRNHRKLAVIDGTIAYTGSMNIETKDYDQGRAEAWHDLMVRVTGPVVMQLQLVFGEDWYLATDKLLEGPGIYPVLDRGGTVPMQAVPTGPMDPTTVLRDLLIAAVSGARERIIITSPYFIPDESLRVALHLASLRGVSVELVIPFNADHPVVGAVARAHFECLIDGGVNIYFHRGVLHAKTMSVDDEVSLVTTANFDRRSLFLHSELSLFLYGREVTARLRDLQSKYIAHSDKVDPARWKRRSVIRRSRDEILKLLSPVL
>NC_008554.1|WP_150109602.1|281347_282484_+|MFS-transporter
MAVANLSCLASFSVFYLFPLFITQHGGDKADVGIIMGATALASVVFRPWISEMIDRMGRKRSYTLGSFLMTVLPLVYLYFDGTIVSFYLPLLIIRIVHGIGFAVCITAAFTFVADLVPKDRLNEGIGMFGVSGLVGSALGPAVAELIIRRFDFDTLFYSAAGFSLIGLLVHLPLTETYIHTLKTVKVPFFAVLKQGRILGVAVIAVLFGIGLAAVNNFVSPFAHAVHLSFISVYYVAYSTAAILTRVGGARLVDSLGEDRIIPYALLLTGLGLMSMVFLGGTGVLFAAGLLTGCGHGILYPSLNVRAIRGQPIEIRGKIVGVYTGSIDAGVFAGSIILGYVGDLLGFRVLFLSAGVALLAGLGIFAATAGRALRARGI
>NC_008554.1|WP_049766251.1|280560_281226_-|class-I-SAM-dependent-methyltransferase
MNDIMETDSGDRYRRLAPLYDGLTAPFLWSVRSDIRRIVQECGYRTVLDVCCGTGRMAMMLHGSGFSVSAVDLSPSMLARARKNSPPGIRYFLEDAARLHFQTASFDCAIISFALHEMNPSKRMHVLAETSRVTRKGGAIIVADYIRPRGMLANGFRAVVNIVERIAGKDHHANYVTFVREGGLEPLAAGLGMKLTVRRRAFMDNAAVMVIEANGTPRTLI
>NC_008554.1|WP_083763894.1|279797_280568_+|hypothetical-protein
MQPYSESRPNEASFTVASYNTHRCVGIDRKYDPERTARVIRELDADIIGLQEIDAGFYRSQGSRQLERLADATGLNVVNGPTKRGTGGHYGNVLLTSRKVVGVRRIDLSVYGREPRGAIDVDLDVDGEIVRVMVVHLGLGGLERRRQVNRLLHGCSSEQEQLHVVLGDINEWFPLGRPLHRLHRHFGKSPARRTFPSFLPVLALDRIWVKPLDALMEISVHDTVLSRVASDHLPIKATITRMDATAACAGSLSGVK
>NC_008554.1|WP_011697112.1|278821_279436_+|phosphoglycerate-mutase
MSRILLIRHAHTDMIGVALSGRMPGVCLSNRGREQAERLAADFVQVPLDVICSSPLERTLETAQAISGTTGAPVEIRDGLIEIDYGEWTGWKLTDLMTDEQWRMFRSFHGGMRIPGGEHIDEVRVRMVGEVEELQRRFPTGVVALVSHADPIRAVLAHYAGIPPELSHRVTISLASVSVLAMNDGPPRILCINRTEDLRHYLEA
>NC_008554.1|WP_011697111.1|277619_278678_+|hypothetical-protein
MDKGSCNVVVTGDLTGEMEPEQAKNHLCRSFGCDRAVADILVGGQAVVIKKNVSRAVAMQYATVLREAGVVCEIEDAAELEAEPTRPGSGEERPAAPVVGTPPVVCPNCGHAGSSPEECVKCGIIYARYRQAKVPETGADDSFSISTGKGREKGTPFKLLLLLVVLGLGVYFIRFKGEVRHPPGILVDSEPTQIIGRSSQSWVKGTKTVVPLARFRIKARVLSTERYRFGEQAELCPLDLALGWGIMSDQRMLDKLVIAQGNRRYALEPLDPNVRLPWAEIMSHSSNVHIIPANEEIEEAVFRFRPGDIVELQGYLVGVKENGQWVWFSSLSRTDLGDGACEIFWVERAAVR
>NC_008554.1|WP_011697121.1|288480_289383_-|phosphodiester-glycosidase-family-protein
MRFSKGYDRKPELLPARPGTATSPRSRTSFLLLVSFLLFTCVFPAWASDEKDPWKVLDEGLGVAEFSSSSSDELEYRITVVRIDPRYYAFKLINASENTREKMTAREWSRQFNLIAAVNAGMYQEDGLASVGYMKNFDHVNNPRLGRDKTVLAFNPSGPDVPEVQIIDRECQDFNSLRQKYRTFVQSIRMISCDRKNVWRQQAGRWSTVAIGTDETGKVLLLFCRSPITVHDFIEVLLTLPLSLQRAMYLEGGPQASLYLSTGKTTLERYGSWEPALEQNSSIQIPLPVPNVIGIVKKTP
>NC_008554.1|WP_041439546.1|289786_289954_-|DUF1328-domain-containing-protein
MIAWALIFLAVAIAAGVLGFGGIIGAQAWIAQVLFILFLVFFLVSLLSGRKPPVT
>NC_008554.1|WP_011697123.1|290424_292389_-|peptide-transporter
MYEDKELKEYRDLLKPPEKFEEGFGWKSIVGAIFIGFLMMPGSMYLGLVVGTGIGPAARWVTIILFAEIAKRAYTRLSQQEIFVLYYMAGAALASPFSGLLWNQYLVQSEAARMLGLTQHIPAWIAPQPGSEALVDRTFFHRDWLIPVLLMVGFELISAVDHFGLGYALYRLTSDVEKLPFPMAPVGALGNMALAESTEKEESGWKWRVFSVGGMIGLAFGALYVLLPAASGVILSEPIRLFPIPWIELTHATEDFLPAVATGIQLDLGLLFLGMVLPFWAVIGGGVGLIITMVANPILYNYGILHRWHKGMGTVDTVFANNFDFYMSFSIGLGLAIAVIGIVHVSISFRQKYQGTLKERFRVLFSPPPGRGDFSVWIAIAIYVVSTTAYVILSSLLVPGFPWIFLVAYGFIYTPIISYVSARMEGIAGQFVSLPMVREASFIAASRFFGYTGIGIWYAPIPFHNYGKATVRWREIELTGTSFRSIIKAEILVIPVVLIASLLFSQYIWKLAPIPSTQYPYAQELWHLQALNSLLLQSATLEGNSPFFQALKLNYLGWGMGLGMATYWLLAALRLPVMLIYGVTRGIGQTTPHGIILEILGALLGRYYFTKKYGLSWRQYAPVLLAGFSCGMGLMGMLAMGFTLIMRSLRSMAY
>NC_008554.1|WP_011697124.1|292504_294484_-|hypothetical-protein
MRELRIRFPALAFGLVLVLLCCVFTPYNNIRLQNSPVAGGHFPLASFVCLFIILVVVNPALGAINRKWRFHYHELLLIWAMVTVATGIAYTGLMRTFIINITSPTWLKLSSGETGQLLQSFLPSALFPNDPEMVRTLYSGFSGGIDMTWWQVLSRIPWSAWLTPMFWWAIFIGLVYMAMLGMVGLFSHQWIENEKMNFPLLRVPEVLSQEAEDKTLRRFLTHRYFIVGLTIPVLLHLLNGLHTYFPQVPQIPTLVLAQPYIPKEGLLSGFYKMKIYIYPAFIGFAFLASKQVSFSLWSFFILGGLLPGILKLVGWRFPAAALGTTFGPVLSKVEEMQMIGAFGMYFFFLLWLSRQHLLAVLKSAFSRSRETPEYCGLMSPRPALYLFFIGIVGITAWLTFFGMSLLSAILFLAVCFMLQLVASRLICQGGLPYFTLTLAPSDGFLAFLDTRLIGPATLGMAVILQKVTFLDMRESLMPSICHASKLSDGSRPRNRFLWGIVWAIALGMVVSFAAMLALYYRYGVNALPDDWAIESTRRVHENVTHLFSHPEEPKSWSIAFTLIGAAFMGLLVMGYHRFIWWPLHPIGYLVTYSSAMQILWFGFFIGWLCNTLVLRYGGANLYREIRRLFIGLIVGDMIMAVIWLIVGLFTPISYHVLPL
>NC_008554.1|WP_083763896.1|294562_299335_-|FtsX-like-permease-family-protein
MMPTDAKTRSGFNRAARIVLLAWLTACPLWSGLFPGVGYGREVMDHVAFFTDLKDRSAGSPGSDAAADYILDFFKKAGLSEVASQQFLTPVPEVVSASIEAEGRTVNLYPWGPNLVYLPMTPENGLRGQLIYAGRGDFKDFDRTRLYESIVLMDMESSGNWINAASFGAAAIVFIGRDDSVKGQFEEKDTRTPLTIPRFWVPAGDGEALKRLAMEKTPQAVVKSKTRWQNKLVRNCYGLLKGSDPKLRKEMVVVDAAYDASFRVLGLAPGADEATSVAALLILAEEFSRHPPARSVLFVATVGNNESHDGMRHLIWSVKTKKKSLKKLTNQLKDTKARIDDQYDLLEKGRYLEQEKPADRESILEILVEKAKDRADALSREIQYRRSASALELAEAQEGPRAYRQIAMVNDIGRLTAQQRELAVQLLDEAVEDRRATHKELKVRVQAMKSSTALRGLLEEYTQVLFFDLHLSSHYETLGLIETGETFPVRESIRKISRAGRLIGLFTQSGRETAAETGIPDIFRDTSRGASPEEISVRAGSVCHPASDVASIAGLPAVSLVSLEDRRLLWSTPADTLDRMDRKKVETLSGFLPPALRRLFSEPSLKSAVDAGVSGLSNLEGQAMFIRQGELFPDQPASGTIISILQGDSVFRTMVLRDGTYFMPGLANKRVSLEKLILEPYGIDPATGRIGIAADKAKTGKENYRISVKSDLASAPLIMFRCLQTDILPIFNPRNMGYLTKLELIDAATEAPPLRHWYSRVDGRDTMSISLFLEKGTRFKLIMSESLLGKEFFLLNGIPENPNGIGFLVGEPPTVSVAPYHVAKDLYSLVGGRLRNLFQHGIVNVHLEELYRQAGTELEQGILALSEHRYGDFWDRVATAWAKLDIVYAEVEGNQRDVLGGVMFFIALFVPFAYCMERYIFCFRGIYQQIVAFFLILIMTILAIRGLHPAFQLTYSPMVVIIAFFIVGLSLLVSAIIFIRFEKEMEDLQTRQAHLRTPQASKWQAFGAGFSIGVSNLNRRKLRTGLTCVTLIILTFTVMSFTNVKSLHRSTLTRIAEDNPYEGVLLRHQFRLPMTMLTLEDMKARFGPEGASIWPRGWIEPAGLTERTISAVYASGRHAPVEGLLGLGPSAPEVFTRLVTKGRWLNETDDRAVLLPLAMAARLGLDPERDLNVPVEIMGARFTVVGFFDGSALDEAKDLDRHPITPAYLEVSHGEELSEVEIEAMQTGEELLPQTERFRYAAGNRTVIMPFAKCVEYGGKLKAVSILPRSSPTEIADRLSTWLAYPLFVGENGTWYHSASTTLRYSGVANLLVPILIVIFITLNTMIGHVHERQKEISTYTSVGLAPTHVGFLFIVEALSLAVISTVLGYILAQLSAKYLGNTAMFSQLTFNYSSLASVACMFLVFSVVFLAALYPARLAAQIAMPDVNRSWTLPAPEGDVIHMNLPFLLKAEEEAGIMKFLKAFYGSHQDVAHGSFIVDEIDMDDALPPVRPGQNPIPVCIVIRTNAWLAPFDFAIKQRVHLHCCPSEENPGYLEIAIQMTRISGERSAWVRANNSFIKALRKQMLLWRLLDADTKAIYYLPEQSETAG
>NC_008554.1|WP_011697126.1|299331_300066_-|ABC-transporter-ATP-binding-protein
MNPVLSHNVVRLSEVTKVFKMGNNVVEALKGVNFSIKAGEYISIMGPSGSGKSTLFNMIGALDKPSTGRVFIDEVDVAQLDAYELAWLRCRKIGYIFQTFNLIQVMTAIENVTLPMIFAGMSRDEYMEKGMVLLRLVGLAERCHHKPSELSGGQQQRVAVARALANDPAIILADEPTGNLDLSTGEEIIALLKQLSTERKVTIISATHDIKMLNVSDRVVWIRDGRIDRVEERDKLKISIGQVA
>NC_008554.1|WP_049766451.1|300092_300737_-|FtsX-like-permease-family-protein
MQRQVVLPFSQLVKISFNSIRVRFFRSLITTLTLALAVAFVSFTWSGYELLNAFFPHADGTVQAGILAGGYELENGRFGAGAKDQWLVILSLLVCVVGIVNAQLMAVTERFREIGTFKCLGALDSFVVRIFVLESIYQGLFGGFVGGLAGVLIATGSFLFRAGWICLACWPPGSMLLTVAGTTLLAVVLSLLGAIYPALVAAKMQPAIALRNEE
>NC_008554.1|WP_011697128.1|301177_302302_-|hypothetical-protein
MKIMFYSQHVLGIGHFFRSMELASALANHEVLFVEGGDALPGYVPPPHVRRLPLPGLMMDQDFKAIHAVEGTVGETRARRKQLLLGTFLSFRPDVLITELFPFGRKQFRFELMPLLECIRQEGMSTGVICSLRDILVEKADQDAYEKGVLEILNAHYHHLMVHSDPRIMRLDETFSRVDEIAIPMSYTGFIARKPGRRRRPPRRRTIVVSSGGGKVGVDLLEAALTAFRLLPELDAGLRMFIGPFMEAADRNVLASLAARDSRTSIEEFSYDFLDCMAESSLSISMAGYNTCMDILSAAVPALVYPFPQNREQMLRARKLEELGFLKVLDGLDPHGMASAAAAAMARRKLQSESMPPDLAGAANAALIVEKCLG
>NC_008554.1|WP_011697129.1|303177_304347_-|ABC-transporter-permease
MFLLARYSYRNLWVRRLTTALTAGGMGLVIFVFAAVLMLAAGFQKTLVTTGSPDNAVFVRRSSEAEVQSLVSREEAAIVESMPEIGLGRDGTKLAAREAVILINLSRRDTGNLAHVTVRGINPKLSMQLRPRVRISAGREPRSGTSEILAGRSIMQRFAVGGLGQTMSFGSRTWTVVGILDAGGTGFDSEIWADVEVLMTTFRRSAYSSVIGRLREPSAFQDLRKRAMSDPRLTLETWRETDYYASQSELMARFIRILGLTLTLIFSLGAVIGSMVTMYSAVANRVSEIGTLRALGFRRATILTAFLLESVFLSLVGGGLGLAAASFMNRISVSTMNWQTFSELSFRFALDSSIVVNALAFAVVMGLVGGILPALRAARMNIVTALRLQ
>NC_008554.1|WP_011697130.1|304390_306253_-|hypothetical-protein
MSELLHSFHIPVMGTAFTIESPFKVARYGISSVISLVDDTLIEKMRRFYCRVMGRECTHIRKQDHDSRADRITAYLNLMDEAVKEQFEKLKASAFEMGSEITKYFELLPETSPLKQLYKAMQSLKDSVEKRRIQDELRERIKPGAIDVNIMTKVDRHTFDGNGEPLPSEFSDALAALRGYARSSVESSIVFSAGFNGRLYGYAEQFDDFHADENGNIKKKIVIKVNDYRSALTQGKFFAKKGLWVSEFRLESGLNCGGHAFAHGGALMGPSLEEFRNRKDELIATLFEIYNRALRQKKKRTFDRPHALRITAQGGIGTAGEQSFLLRHYRLDATGWGTPFLLVPEATTVDPTTLKRLCEAGREDLFLSDVSPLGVPFNNLRTSLSEEAKRARIRTGKPGSPCTKGYLKSNTEFSETPICVASRAYQERKIEQILAGGSDPESARAAIEAVTSKSCLCTDLGGTAILTHGLAESEDGPCVPAICPGPGLAYFTRAVSLREMVDHIYGRADIIENRTRPNLFISELEMYIDYFDNELRRSLPHPNEQTAKYLREFETNLLEGIAYYQELIPRWSDGPPEYRARMKRDLGLCRERLLEVASHFHDMPSLDPDAGLAIGRETAL

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Crispr_ID: NC_008554_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_2

475038-475129

Orphan

Consensus_repeat	Method
ATCCTGAAACCCCCTGACGCCCGGGCGACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_2

>merge|NC_008554|2|475038-475129|CRISPRCasFinder
ATCCTGAAACCCCCTGACGCCCGGGCGACTTGCCATGGGCAATTGTTTTCAGGATGGGTGCATCCTGAAACCCCCTGACGCCCGGGCGACTT

>NC_008554|2|2|475038-475129|CRISPRCasFinder
ATCCTGAAACCCCCTGACGCCCGGGCGACTT	GCCATGGGCAATTGTTTTCAGGATGGGTGC
ATCCTGAAACCCCCTGACGCCCGGGCGACTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_041439598.1\|478112_480464_+\|DUF4115-domain-containing-protein	unknown	unknown	gnl\|CDD\|379201
NC_008554.1\|WP_041439593.1\|475486_476026_+\|cation-binding-protein	unknown	unknown	gnl\|CDD\|226454
NC_008554.1\|WP_011697256.1\|459106_459832_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NC_008554.1\|WP_011697260.1\|463380_465231_-\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|274526
NC_008554.1\|WP_011697262.1\|467523_469047_-\|acetyl-CoA-hydrolase/transferase-family-protein	unknown	unknown	gnl\|CDD\|274588
NC_008554.1\|WP_011697274.1\|483481_484270_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213228
NC_008554.1\|WP_041439600.1\|480645_481284_-\|dTMP-kinase	unknown	unknown	gnl\|CDD\|234814
NC_008554.1\|WP_011697273.1\|482018_483035_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|376804
NC_008554.1\|WP_011697276.1\|485216_485657_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	unknown	unknown	gnl\|CDD\|275223
NC_008554.1\|WP_150109603.1\|469356_471519_-\|LUD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224062
NC_008554.1\|WP_011697265.1\|472345_473728_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NC_008554.1\|WP_011697269.1\|476245_477436_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|372434
NC_008554.1\|WP_011697259.1\|462835_463363_-\|indolepyruvate-oxidoreductase-subunit-beta	unknown	unknown	gnl\|CDD\|180732
NC_008554.1\|WP_011697277.1\|485787_486393_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|377516
NC_008554.1\|WP_011697264.1\|471518_472076_-\|LUD-domain-containing-protein	unknown	unknown	gnl\|CDD\|376839
NC_008554.1\|WP_011697257.1\|459850_461695_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|213186
NC_008554.1\|WP_011697272.1\|481335_481956_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212134
NC_008554.1\|WP_011697275.1\|484266_485043_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376777
NC_008554.1\|WP_011697261.1\|465979_467491_-\|succinate-CoA-transferase	unknown	unknown	gnl\|CDD\|274588
NC_008554.1\|WP_011697258.1\|461730_462612_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_041439598.1\|478112_480464_+\|DUF4115-domain-containing-protein	gnl\|CDD\|379201	pfam13464, DUF4115, Domain of unknown function (DUF4115). This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.	2.84617e-12
NC_008554.1\|WP_041439593.1\|475486_476026_+\|cation-binding-protein	gnl\|CDD\|226454	COG3945, COG3945, Uncharacterized conserved protein [Function unknown].	1.02819e-13
NC_008554.1\|WP_011697256.1\|459106_459832_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	2.46206e-118
NC_008554.1\|WP_011697260.1\|463380_465231_-\|4Fe-4S-binding-protein	gnl\|CDD\|274526	TIGR03336, IOR_alpha, indolepyruvate ferredoxin oxidoreductase, alpha subunit. Indolepyruvate ferredoxin oxidoreductase (IOR) is an alpha 2/beta 2 tetramer related to ketoacid oxidoreductases for pyruvate (1.2.7.1, POR), 2-ketoglutarate (1.2.7.3, KOR), and 2-oxoisovalerate (1.2.7.7, VOR). These multi-subunit enzymes typically are found in anaerobes and are inactiviated by oxygen. IOR in Pyrococcus acts in fermentation of all three aromatic amino acids, following removal of the amino group by transamination. In Methanococcus maripaludis, by contrast, IOR acts in the opposite direction, in pathways of amino acid biosynthesis from phenylacetate, indoleacetate, and p-hydroxyphenylacetate. In M. maripaludis and many other species, iorA and iorB are found next to an apparent phenylacetate-CoA ligase.	0
NC_008554.1\|WP_011697262.1\|467523_469047_-\|acetyl-CoA-hydrolase/transferase-family-protein	gnl\|CDD\|274588	TIGR03458, Propionyl-CoA:succinate_CoA_transferase, succinate CoA transferase. This family of CoA transferases includes enzymes catalyzing at least two related but distinct activities. The E. coli YgfH protein has been characterized as a propionyl-CoA:succinate CoA transferase where it appears to be involved in a pathway for the decarboxylation of succinate to propionate. The Clostridium kluyveri CAT1 protein has been characterized as a acetyl-CoA:succinate CoA transferase and is believed to be involved in anaerobic succinate degradation. The propionate:succinate transferase activity has been reported in the propionic acid fermentation of propionibacterium species, where it is distinct from the coupled activities of distinct nucleotide-triphosphate dependent succinate and propionate/acetate CoA transferases (as inferred from activity in the absence of NTPs). The family represented by this model includes a member from Propionibacterium acnes KPA171202 which is likely to be responsible for this activity. A closely related clade not included in this family are the Ach1p proteins of fungi which are acetyl-CoA hydrolases. This name has been applied to many of the proteins represented by this model, possibly erroneously.	0
NC_008554.1\|WP_011697274.1\|483481_484270_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.32795e-123
NC_008554.1\|WP_041439600.1\|480645_481284_-\|dTMP-kinase	gnl\|CDD\|234814	PRK00698, tmk, thymidylate kinase; Validated.	6.26744e-83
NC_008554.1\|WP_011697273.1\|482018_483035_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|376804	pfam02511, Thy1, Thymidylate synthase complementing protein. Thymidylate synthase complementing protein (Thy1) complements the thymidine growth requirement of the organisms in which it is found, but shows no homology to thymidylate synthase. The bacterial members of this family at least are flavin-dependent thymidylate synthases.	4.83799e-24
NC_008554.1\|WP_011697276.1\|485216_485657_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	gnl\|CDD\|275223	TIGR04430, OM_asym_MlaD, outer membrane lipid asymmetry maintenance protein MlaD. Members of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier.	8.75136e-46
NC_008554.1\|WP_150109603.1\|469356_471519_-\|LUD-domain-containing-protein	gnl\|CDD\|224062	COG1139, COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion].	6.71349e-146
NC_008554.1\|WP_011697265.1\|472345_473728_+\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	7.92375e-172
NC_008554.1\|WP_011697269.1\|476245_477436_+\|HD-domain-containing-protein	gnl\|CDD\|372434	pfam13023, HD_3, HD domain. HD domains are metal dependent phosphohydrolases.	6.443e-30
NC_008554.1\|WP_011697259.1\|462835_463363_-\|indolepyruvate-oxidoreductase-subunit-beta	gnl\|CDD\|180732	PRK06853, PRK06853, indolepyruvate oxidoreductase subunit beta; Reviewed.	1.61707e-51
NC_008554.1\|WP_011697277.1\|485787_486393_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|377516	pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.	4.65104e-45
NC_008554.1\|WP_011697264.1\|471518_472076_-\|LUD-domain-containing-protein	gnl\|CDD\|376839	pfam02589, LUD_dom, LUD domain. This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate.	1.20975e-31
NC_008554.1\|WP_011697257.1\|459850_461695_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	1.68228e-100
NC_008554.1\|WP_011697272.1\|481335_481956_-\|hypothetical-protein	gnl\|CDD\|212134	cd11527, NTP-PPase_dUTPase, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins. dUTPase (dUTP pyrophosphatase; EC 3.6.1.23) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate. It acts to ensure chromosomal integrity by reducing the effective ratio of dUTP/dTTP. Members in this family are dimeric dUTPases, such as those from Leishmania major, Trypanosoma cruzi, and Campylobacter jejuni, which differ from the monomeric and trimeric forms and adopt an all-alpha topology. A central four-helix bundle, consisting of two alpha-helices from the rigid domain and two helices from the mobile domain and connecting loops, form the active site in dimeric dUTPase-like proteins, requiring the presence of metal ion cofactors to hydrolyze both dUTP and dUDP.	1.90546e-14
NC_008554.1\|WP_011697275.1\|484266_485043_+\|ABC-transporter-permease	gnl\|CDD\|376777	pfam02405, MlaE, Permease MlaE. MlaE is a permease which in E. coli is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. In NMB1965 it is involved in L-glutamate import into the cell. In Arabidopsis thaliana TGD1 it is involved in lipid transfer within the cell.	3.99327e-70
NC_008554.1\|WP_011697261.1\|465979_467491_-\|succinate-CoA-transferase	gnl\|CDD\|274588	TIGR03458, Propionyl-CoA:succinate_CoA_transferase, succinate CoA transferase. This family of CoA transferases includes enzymes catalyzing at least two related but distinct activities. The E. coli YgfH protein has been characterized as a propionyl-CoA:succinate CoA transferase where it appears to be involved in a pathway for the decarboxylation of succinate to propionate. The Clostridium kluyveri CAT1 protein has been characterized as a acetyl-CoA:succinate CoA transferase and is believed to be involved in anaerobic succinate degradation. The propionate:succinate transferase activity has been reported in the propionic acid fermentation of propionibacterium species, where it is distinct from the coupled activities of distinct nucleotide-triphosphate dependent succinate and propionate/acetate CoA transferases (as inferred from activity in the absence of NTPs). The family represented by this model includes a member from Propionibacterium acnes KPA171202 which is likely to be responsible for this activity. A closely related clade not included in this family are the Ach1p proteins of fungi which are acetyl-CoA hydrolases. This name has been applied to many of the proteins represented by this model, possibly erroneously.	0
NC_008554.1\|WP_011697258.1\|461730_462612_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	8.69464e-69

>NC_008554.1|WP_011697265.1|472345_473728_+|FAD-binding-protein
MIGRALIAEFEKLLGRDNVFADEADRHTYSYDAAVLDPVLPALVVRPTSSEGLGRSVRLCGENALPVTVRGAGTNLSGGTIPARGGVVIVTNGLNRILEINEADLYAVVEPGVVTARFAAAVESRGLFYPPDPGSQAVSTLGGNVAENAGGLRGLKYGVTGDYVLGLSFFDANGEIVKTGARTVKCVAGYNLAGLMVGSEGTLGVFDRIILKLIPIPAARKAMLAVFDDIAKACEAVSGIIADKIVPATLELMDNFTIRAVEDYGHAGLPVDAAALLLIEVDGHAAQVEEDASRVEAVCRGRGAMSLRVARTAAERDKVWEARRAALSALAKLKPTVVLEDATVPRSKIPAMMNSLEAIASRYRLTIGTFGHAGDGNLHPTILTDRRDRAEWSRVEAAIDAIFDEALKLGGTLSGEHGIGLAKSRFLEKETSRATILYSRRIKTALDPKNILNPGKIIGE
>NC_008554.1|WP_011697264.1|471518_472076_-|LUD-domain-containing-protein
MDRGELIAKLKERAAAVQSVALEIGSFDAAMRYAVDLTARQGGRSIAAPGLPDDRLSDLATLCAGRDIELLTGGLRQRLSGLHTGLTEADWGIAETATLVLDSSAEDIRIATMLVETHVAILPASRLRATAFDLEPELGRMLRGRPSYLAFISGASRTADIERVLTVGVHGPQELHILILEDNGS
>NC_008554.1|WP_150109603.1|469356_471519_-|LUD-domain-containing-protein
MTTPRNMKEYKAQVRRALKNRFLATTLENFAAAYPVSRANAFEGIDVEALVEEIARSKDACIPYLEELYARFKTNAEAAGMKVHRARTALEANALIAGIARESGVTRIVKGKSMTAEETFLNDRLEKDGFKVTETDLGEWIIQLRGEGPSHMVMPAIHLSRREVAELFRRVTGRPMDPDDIDGMVKVARRELRQAFLEADMGISGANFAIADSGTIGLVTNEGNGRLVTTLPRVHVALVGFDKLVPDLESALRILRALPRNATGQVISTYVTWITGAVECPPAPGGRKETHIVFLDNGRLALARDPLFAEALRCIRCGACANVCPIYKLIGGHNYGHVYIGAIGLILTFFYHGRENARTIVRNCLNCQACKAVCAAGIDLPRLIKEVYGKILRIEGGKPLKNRLLGRVLKDRPLFHFLLRRAYLAQQPLTRGRPMLRHLPLFFSGEHGFRSLPAIVATPLRDRWEKINPPVPNPRLRVGLFGGCLVDFAYPEQAEALIRLLEGRRIRLEYPMGQTCCGLPAKMTAEDETARRVAAQNLRAMDPDRYDHILTLCASCGSHLRENYPRLLASDARMSAKARQFAARVIDFSSFMIHVLHVEPGSFQGGGRKVAYHSPCHLCRGLGVTREPRELLAAAGFEYVRCKDEDVCCGFGGSYSLDFPMISAELLKRKLDIVTSSGAELLVTDCPGCVLQLRGGMDKREGPKVEVKHIAEAVADARKS
>NC_008554.1|WP_011697262.1|467523_469047_-|acetyl-CoA-hydrolase/transferase-family-protein
MPNSSSCPFPKLTPEEAAALISNGATVAFSGFANAGAAKVVPGAIAARARQLHESGAPFKIRVLTGSSSGNNIDEELAMAEAITWRAPYQSSPTLRKQINRQEVEYVDMHLAHAPQVLAAGFFGRLDYGIIEATEVTRDGRVYLSSSIGASPTYLRYADRIILEINRYHSMRLPEIADITTLPPPPRRNPIPIHDPLTKIGYPYALVDPKKIVGVVETNEPDAVRPYTGPDRKSERIAEHVVKFLFGEMITGHIPKEFLPLQAGVGNMANSVMAALGRNPYIPPFKMYTVVFQDALVELMEQGKLEAASATSLTLTPAVLRRIYDNMDYFVPRLVLRPQEISNDAGVIRRLGVIAMNAAIEVDIYGNVNTSHVYGTDIINGIGGSGEYTRNSYLSMVMCPSISRNGRISSVVPMCPHIDSNEHSVQVVVTDQGLADLRGLGPMQRAKLIIDQCAHPVYRDYLHAYIRDSKVGHIRHNLRKCYELHRNLMEHGAMLPDLKLSEITDAV
>NC_008554.1|WP_011697261.1|465979_467491_-|succinate-CoA-transferase
MSIVGSYPKPSPEEAVSHIFHGATVAFSGFTNAGAAKIVPRALAARARAVHEKGDPLKIRVLTGASSGESIDEPLAQAQAISYRAPYQSGPRLRKQINSQEVEYVDMHLSHLPQTVLSGFQGRLDFAVVEATEITSDGRVYLTSSIGASPTYLKYADKVIIEINHHHSPRLREMTDILIMARPPHRSPLPLHDPLTKVGYPYAVVDPRKVIAVLETDEPDRVPKFTAGDPRSHKIAEHVVRFLLDEMLAGRIPNEFLPLQAGVGNVANSVMAALGENPYIPPFKMYTEVFQDSLVDLMQNGKVLAASTTALTITPEVLGRIYANMDYFVSKIVLRPQEISNHPGAIRRLGVISMNTALEFDIYGNVNSSHLYGTDIMNGIGGSAEFTRNSYLSLFMCPSIAKGGRISSVVPMCPHIDNNEHSVQVVVTDRGLADLRGLGPMQRARTIIEKCAHPLYKDYLYRYIEKSRIGHIRHNLEDCFELHSNLMDHGAMLPDLDLSGVTE
>NC_008554.1|WP_011697260.1|463380_465231_-|4Fe-4S-binding-protein
MTERSILLGNEAIALGLLEAECTMAASYPGTPASEILRALASLKERHKLDLHLEWSINEKAAFEVALANSYTGRRSATIMKQVGLNVAADPLMSAAYTGVKGGFVLISADDPGPHSSQTEQDSRLIAMVAKIPVFDPSSPEEAREYARRACALSEKHEIPVMLRPTTRVCHARQDMDLRPVPHPKQFPLFEKNPGRWAATPKFRLVLHRQLNEKLARISRDPDCAPQLVNGDALGPGTRDGGRACIVGSGVVTAHAQEILGELGLWDRVPFYRLPMPYPLPESFRDDLLSSYDRILILEETDPVIELQLQNREKIFGRTTGHVPTAGELLPEVVEGILRSFLGLDPSPPVEPPAYPGRRPTLCAGCPHRAAFFAIKKAFPKGIYPGDIGCYTLGLNLGVVDTVLCMGASINQAAGFYHAYRSARRDMPPICATIGDSTFFHAGVPALMNAVVQGARFVLVVLDNSTTAMTGHQPTPALGRNLDGIPVPRLSIAELAKACGVRSVAEGDPYDFDRFLDLLKAAGRHAGAEDGGVAVVIAKRPCLMDRNQPRTWPRLRIEVNEKCKGCDFCVKQFECPALRPRGEKEPIVIDDSLCSGCGVCVRVCPHGALEAVSEGH
>NC_008554.1|WP_011697259.1|462835_463363_-|indolepyruvate-oxidoreductase-subunit-beta
MQQIIVSGIGGQGVLFVTKLLAQTAVDTGRSVLLSETHGMAQRGGNVISHLKVAPREQSGTSPVSPLVRPGHADVLLALHPDALAAHGFFLRPGGRAFCNASGTTAEGSLDASAIAGSLGSAVSANLVLLGFAAASGALFCDPAQLETTLARIGGKRTESSLAAFRAGLKAASAP
>NC_008554.1|WP_011697258.1|461730_462612_-|branched-chain-amino-acid-ABC-transporter-permease
MPWQLIPHFFVSGVTNGSIYALIALGYCLIQNATGLVNFAQGEFVMLGAMIVITLHNVMGLPMPLAFVLSTAAVAIIGTALERGPIRLSRNRDVLTLIMITVGASIAIRGASMMLWGKSSHVFPSFGGDDPIIVLNAAILPQSLWIMALSLAALVLLYLFFHRTLLGKAIRGVADNSLGAVLIGISVRRLVALSFALSGALGAMAGVLITPITSMSYDGGLMLGLKGFAAGILGGYGSTLGAVVGGLLLGVLEAFGAGLVSSAYKDAIAFLVLLTILFVRPAGLFGSVRVHRL
>NC_008554.1|WP_011697257.1|459850_461695_-|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease
MNLIIVPRQWRALLPLAVVLWGLPLVMRNDYLLLLCNVMALNAMVVLGLNLLIASTGQVSLGHAAFYGLGAYLSAIASTTWQWPLFAALAFAAASVAVIAFLLALPTLKLEGHYLVMATLGFNIIVFICFNQMESVTGGPSGFSGIPRLALGSFALNTDLRFYVFIWTLFLVAFALTLNLLDSRLGRALKAIHQKELTAEVLGIPARRYKIVTFVLSTVYAAVAGFSYAHYVTFISPKTFDIFYSVQIVTMVAVGGMGSLWGGLAGTILLTALPEFLHHFEDLHVLLYGLTLMGVLVFCPQGLLPALKSLLSARLKTGGTAILRPAGMDRPPASVRAGRGRIVSAPFPAGHPAGTGMQGDLPALKLSDISLDFGGLQALNQVGFDIPGGRVVALIGPNGAGKTTLLNVVSGLLRPRNGQILLRDRSLIGKSPCLVAREGIGRTFQAVQIFQDFTVLDNLLLGYHLQGRAGFLAGYLHTRAERREEAVLRDRALEHLDDFGLAEKAHSPAQQLSLLEQKLLELARALALSPSILLLDEPVGGLNPRESEVLVETISGLRERGIGVLLVEHDMNVVMQLSDRIEVLQHGNRIASGPPREIRQDPRVIAAYLGTRRR
>NC_008554.1|WP_011697256.1|459106_459832_-|ABC-transporter-ATP-binding-protein
MLRVKGLSVRYGSVQVLRRVSFHVAENEIVALIGANGAGKSTLLRALSGINRPFEGEILFRGEPLLKVSPERIVRMGLVQVPEARQLFPNMTVLENLELGGYLYGLKHVRAKLAEIYELFPVLMERSRQKAGTLSGGEQQMLSIGRALMARPRLLVLDEPSMGLAPLIVEEIYRTVEALHREGTTVLLVEQNAMGALAVAERGYVLETGRIVLSGRADELMEHDDVQRAYLGKDYEYKWER
>NC_008554.1|WP_041439593.1|475486_476026_+|cation-binding-protein
MKPIGPMMWEHRLIEQMLRVCEKEIEKVKESNKLDVIFIDAVVDFIRTYADRTHHGKEEDILFRDLEKKQLSPEHARIMKELVDEHVHSRETVKQLVEAKERYLRGEGTAREVVAHLEALARFYPLHIEKEDKHFFHPCMEYFTKEEQDRMLAEFYEFDRKMIHEKYRDVVERMEARGA
>NC_008554.1|WP_011697269.1|476245_477436_+|HD-domain-containing-protein
MIRKGLIDKLFEAASIQRWNDHVRPVEFTELDKQAHKMIIAYVLGKLEEGQRLARIDWRKLIEGGIFEFLHRVILTDIKPPVFHKMMSKKGAEINAHVCRKLEQDVRDIGGDFAEKLKSYLFDRDYSPFEKRLLKAAHYLATNWEFQIIYSAAPFIYGIEKTKEEIENQIEDHYDLIGVQKISLRKKSFGFIDLCGQLRFQQRWAHSPRVPKTSVLGHVLIVAMLCYFLSVEIDACDRRVYNNFFAGLLHDLPEVLTRDIIHPVKRSVEGLEEIVKEYEEIQLEEKILPLLPSSMREEIVYFLQDEFKNKIIDAGAVKKGVSGETMDACNSDAYSPLDGEIIEVCDKLAAFIEASLSIQHGIKSHQLEEGKRFSYENYRDKRVGKLRFGYLFDYYN
>NC_008554.1|WP_041439598.1|478112_480464_+|DUF4115-domain-containing-protein
MDDHTEDVYKMREMVESFAQRRAEDEKRAYPRFMTPEGLTGRIDPGNLSGMLLYRKDRPRGQQHGTASDRHGDGPEGHSAPGGDFEKVSDICILDFSEEGAQVYFRCENPFKITQNRLFFQIGASRLPVWLRWYQISREGNTAGFEFAEARERNQDLAHVLVSLSDRLVSFLIGEYLPKAKKDHAQACVYAYLSILYNLRLRFLETVASFYKAQACAEKCVTSRHHREIMGTLFEFESLRTLHFRQARALGGDKPFKATLEFFMKPYRDHQCGLSGRHQKVCFLENDVMNALMDSIVFWNWSIPPPDELNDRIKPVYKSFLALRSHLPGVFDGAEFDRQFIYYSFLIRSVILLKDKLIDVVSSSCPFAGQGRWGEGTAAGTGAGKSGLSVKASDLLGKEEFEEIGTPALERKLTETFGPDADVEPAVVHEARRVSGTWRGFPRMDRYLVMGPLILAICFGIAVLMWSKERPSSEAPVRPERSSLQAEAAPGPPAVGVVPRGAGPAEGAGVSPEPDVHASDDARGTLRRRAIASIPASVPEQALASVPGSGPAPVKEQPSSETTARPERSPLQAEAASVPVAAGVPGLTNTSVPNPAPNERNDSQGNAPDRTASPVPGDTPDGGAGKFAGSTASISGGGQEPKGEAAEPGEEKIAMVGGPQVAMAVPVPSARTSAPEKSKDVAPAAPPGTPLVHDFVVEAIEPSWLQVTIDKGKPWATTLQPGNRFEWKVRDRINLVVGNAGGIRIVWDGQALDPPGNPGQPVRLTLPEPQREPQRKAKSRTRR
>NC_008554.1|WP_041439600.1|480645_481284_-|dTMP-kinase
MKPISPKFVTFEGIDGCGKSTLIDELASWLDRTRVPYVKTREPGGTSLGEKIRGLLLDPAHRGMNRQTEVLLYTASRAQLVAEIILPALKSGAWVLADRYIDATLAYQGYGRELDPDPLRRLQHWATQALVPDKTVLLDCGIDTAAARMSARNHRPDRIEMEERAFHERVKAGYLDLASLDPGRFIVLDAEKPLPEVIADFRAAFREIVPAP
>NC_008554.1|WP_011697272.1|481335_481956_-|hypothetical-protein
MKDIFDRQMQLNIYTLRNIGLDFSTTVADPLEKTVWIENYRKAFSAELAELVREVRERGVGTHNGRIEVVDLLHFLVSLSQIVGVAPSAAFSMMSDGNPGKGGVAGGTAEQAVMECVVETFLALDDLQGCMKWKWWAKGGGFKPDMAEKAVLDLWKRFGEVCALFDLDFDTTKRIYTAKNEVNFRRQDRDYNEDTKDESDNLAIEA
>NC_008554.1|WP_011697273.1|482018_483035_-|FAD-dependent-thymidylate-synthase
MSVQFVKTRVQPQGIAPAEEGRALQLVELCGRTAYKSEDKITPDSARNFVLMLKSHGHLSVLEHSNIVLEIEATPSSGATQALSSISELYGALLDGLGFRTAYHRIHLSARTSPGALFIAGNLRSWIETLTHLGNGGSPLHALLSAALRDFFPIIFGGEETVSSNLSFKVTLVREDEQLALLRRDAACDLPVFVFKFVCDRGITHEVVRHRVLSFTQESTRYVNYKNKGMVLILPEELYPFYDDATQQLTGRSPLVDMWIDRAEKLFAWYREDLDREKPEIARDILPNLLKSEIFVSGRWSGWKHFVQLRDSKHAHPRIRAIAKEVRNHFDSLGMTVE
>NC_008554.1|WP_011697274.1|483481_484270_+|ABC-transporter-ATP-binding-protein
MIRIERLRKSYDGLVASDDVSCRFEKGKITVILGGSGSGKSTLLKQLVGLERPDSGKIFFEDRELTGLSRSELYEIRKKMGMLFQGAALFNSLNVFENIAFPLREHTRLAEPVIRAMVTMKLEMVGLRGMEQLMPSQLSGGMAKRIGLARAIVMDPRAVFYDEPTSGLDPISAGVINKLIVDLNTAMGVTSVVVSHDIPSSFRIAHRIIILFFGRKIAEGTPEEIRGSEDARVLQFIRGEPEGPIPFNRTEKNYYDDILRVP
>NC_008554.1|WP_011697275.1|484266_485043_+|ABC-transporter-permease
MTISSAFGLNGRRCVHAVRLAGRSLLFLGEALGYGFVPPLKIRRSLEQIVFIGAKSLIIIFVTALSTGMVLALEALHMLRGGATENILGALVALSIVRELGPVLSALIVTGRAGSAMTAEIGIMRLTEQIDALEMMAVNPIKHVVTPKIVAGVVSMPVLCAFFDVVGILGGYFVGVVIYGVPEVHFFGGMTKAVAYLDVAGGLFKSAVFGLAMSWICSMMGYGAAATAEGVSRATTNAVVITSIAVLVLDYMVTSLLL
>NC_008554.1|WP_011697276.1|485216_485657_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD
MYRPSLEITVGVFFILGVVCMAYLSLVVGGPGALGEPHYRVNALFNSITGLRRGAAVEIAGVRVGKVLDITLENNQARVVMAIRDGVRLSDDTVASIRTKGIIGEIFVKLIPGGSGRDIGPGDTLIETESAISIEELIGKYMFEKK
>NC_008554.1|WP_011697277.1|485787_486393_+|ABC-transporter-substrate-binding-protein
MVGKMVIALLLAASLFIAAPASAGEPMEQLRVSVEKVVEILKDPSLKSPDRMLERRNRIFKVVEERFDFSEMAKRCLGEFWPKISEAEQREFEVAFASLLETSYIATIERFDEESVVFEEERPKGRQYFVVHTAVVSGGRSISVDYSVRNVNGQWLVYDVNIEEVSLVAGYRVRFAETFRREGFRGLMKKIAEEAGGPGKG

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Crispr_ID: NC_008554_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_3

485090-485176

Orphan

Consensus_repeat	Method
GGGGACCCCGAGCGGGCGGGTTTCCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_3

>merge|NC_008554|3|485090-485176|CRISPRCasFinder
GGGGACCCCGAGCGGGCGGGTTTCCATACATCAACCGGCTGGTGGGCCGCATCAAGGGGCGGGGACCCCGAGCGGGCGGGTTTCCAT

>NC_008554|3|3|485090-485176|CRISPRCasFinder
GGGGACCCCGAGCGGGCGGGTTTCCAT	ACATCAACCGGCTGGTGGGCCGCATCAAGGGGC
GGGGACCCCGAGCGGGCGGGTTTCCAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_041439598.1\|478112_480464_+\|DUF4115-domain-containing-protein	unknown	unknown	gnl\|CDD\|379201
NC_008554.1\|WP_041439593.1\|475486_476026_+\|cation-binding-protein	unknown	unknown	gnl\|CDD\|226454
NC_008554.1\|WP_011697272.1\|481335_481956_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212134
NC_008554.1\|WP_011697273.1\|482018_483035_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|376804
NC_008554.1\|WP_011697265.1\|472345_473728_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NC_008554.1\|WP_011697266.1\|473730_475044_+\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NC_008554.1\|WP_011697279.1\|487329_488166_+\|rhodanese-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NC_008554.1\|WP_011697281.1\|489219_490572_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271320
NC_008554.1\|WP_041439602.1\|488458_488872_-\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350222
NC_008554.1\|WP_011697278.1\|486486_487233_+\|acetylpolyamine-aminohydrolase	unknown	unknown	gnl\|CDD\|212518
NC_008554.1\|WP_011697269.1\|476245_477436_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|372434
NC_008554.1\|WP_150109408.1\|491932_492418_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697277.1\|485787_486393_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|377516
NC_008554.1\|WP_011697282.1\|491263_491563_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|198034
NC_008554.1\|WP_041439600.1\|480645_481284_-\|dTMP-kinase	unknown	unknown	gnl\|CDD\|234814
NC_008554.1\|WP_011697274.1\|483481_484270_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213228
NC_008554.1\|WP_011697283.1\|492633_496077_-\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|378996
NC_008554.1\|WP_011697275.1\|484266_485043_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376777
NC_008554.1\|WP_011697276.1\|485216_485657_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	unknown	unknown	gnl\|CDD\|275223
NC_008554.1\|WP_041439604.1\|488868_489096_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl\|CDD\|226603

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_041439598.1\|478112_480464_+\|DUF4115-domain-containing-protein	gnl\|CDD\|379201	pfam13464, DUF4115, Domain of unknown function (DUF4115). This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.	2.84617e-12
NC_008554.1\|WP_041439593.1\|475486_476026_+\|cation-binding-protein	gnl\|CDD\|226454	COG3945, COG3945, Uncharacterized conserved protein [Function unknown].	1.02819e-13
NC_008554.1\|WP_011697272.1\|481335_481956_-\|hypothetical-protein	gnl\|CDD\|212134	cd11527, NTP-PPase_dUTPase, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins. dUTPase (dUTP pyrophosphatase; EC 3.6.1.23) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate. It acts to ensure chromosomal integrity by reducing the effective ratio of dUTP/dTTP. Members in this family are dimeric dUTPases, such as those from Leishmania major, Trypanosoma cruzi, and Campylobacter jejuni, which differ from the monomeric and trimeric forms and adopt an all-alpha topology. A central four-helix bundle, consisting of two alpha-helices from the rigid domain and two helices from the mobile domain and connecting loops, form the active site in dimeric dUTPase-like proteins, requiring the presence of metal ion cofactors to hydrolyze both dUTP and dUDP.	1.90546e-14
NC_008554.1\|WP_011697273.1\|482018_483035_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|376804	pfam02511, Thy1, Thymidylate synthase complementing protein. Thymidylate synthase complementing protein (Thy1) complements the thymidine growth requirement of the organisms in which it is found, but shows no homology to thymidylate synthase. The bacterial members of this family at least are flavin-dependent thymidylate synthases.	4.83799e-24
NC_008554.1\|WP_011697265.1\|472345_473728_+\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	7.92375e-172
NC_008554.1\|WP_011697266.1\|473730_475044_+\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	5.87654e-70
NC_008554.1\|WP_011697279.1\|487329_488166_+\|rhodanese-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	5.17319e-29
NC_008554.1\|WP_011697281.1\|489219_490572_-\|hypothetical-protein	gnl\|CDD\|271320	cd05819, NHL, NHL repeat unit of beta-propeller proteins. The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.	6.10186e-10
NC_008554.1\|WP_041439602.1\|488458_488872_-\|PIN-domain-containing-protein	gnl\|CDD\|350222	cd09874, PIN_MT3492-like, VapC-like PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis CDC1551, hypothetical protein MT3492, and similar bacterial and archaeal proteins are included in this subfamily. They are PIN domain homologs of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	8.21213e-39
NC_008554.1\|WP_011697278.1\|486486_487233_+\|acetylpolyamine-aminohydrolase	gnl\|CDD\|212518	cd09992, HDAC_classII, Histone deacetylases and histone-like deacetylases, classII. Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.	3.80908e-46
NC_008554.1\|WP_011697269.1\|476245_477436_+\|HD-domain-containing-protein	gnl\|CDD\|372434	pfam13023, HD_3, HD domain. HD domains are metal dependent phosphohydrolases.	6.443e-30
NC_008554.1\|WP_011697277.1\|485787_486393_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|377516	pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.	4.65104e-45
NC_008554.1\|WP_011697282.1\|491263_491563_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|198034	smart00966, SpoVT_AbrB, SpoVT / AbrB like domain. This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.	5.12782e-08
NC_008554.1\|WP_041439600.1\|480645_481284_-\|dTMP-kinase	gnl\|CDD\|234814	PRK00698, tmk, thymidylate kinase; Validated.	6.26744e-83
NC_008554.1\|WP_011697274.1\|483481_484270_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.32795e-123
NC_008554.1\|WP_011697283.1\|492633_496077_-\|N-6-DNA-methylase	gnl\|CDD\|378996	pfam12950, TaqI_C, TaqI-like C-terminal specificity domain. This domain is found at the C-terminus of the TaqI protein and is involved in DNA-binding and substrate recognition.	2.99746e-12
NC_008554.1\|WP_011697275.1\|484266_485043_+\|ABC-transporter-permease	gnl\|CDD\|376777	pfam02405, MlaE, Permease MlaE. MlaE is a permease which in E. coli is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. In NMB1965 it is involved in L-glutamate import into the cell. In Arabidopsis thaliana TGD1 it is involved in lipid transfer within the cell.	3.99327e-70
NC_008554.1\|WP_011697276.1\|485216_485657_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	gnl\|CDD\|275223	TIGR04430, OM_asym_MlaD, outer membrane lipid asymmetry maintenance protein MlaD. Members of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier.	8.75136e-46
NC_008554.1\|WP_041439604.1\|488868_489096_-\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	0.00013712

>NC_008554.1|WP_011697275.1|484266_485043_+|ABC-transporter-permease
MTISSAFGLNGRRCVHAVRLAGRSLLFLGEALGYGFVPPLKIRRSLEQIVFIGAKSLIIIFVTALSTGMVLALEALHMLRGGATENILGALVALSIVRELGPVLSALIVTGRAGSAMTAEIGIMRLTEQIDALEMMAVNPIKHVVTPKIVAGVVSMPVLCAFFDVVGILGGYFVGVVIYGVPEVHFFGGMTKAVAYLDVAGGLFKSAVFGLAMSWICSMMGYGAAATAEGVSRATTNAVVITSIAVLVLDYMVTSLLL
>NC_008554.1|WP_011697274.1|483481_484270_+|ABC-transporter-ATP-binding-protein
MIRIERLRKSYDGLVASDDVSCRFEKGKITVILGGSGSGKSTLLKQLVGLERPDSGKIFFEDRELTGLSRSELYEIRKKMGMLFQGAALFNSLNVFENIAFPLREHTRLAEPVIRAMVTMKLEMVGLRGMEQLMPSQLSGGMAKRIGLARAIVMDPRAVFYDEPTSGLDPISAGVINKLIVDLNTAMGVTSVVVSHDIPSSFRIAHRIIILFFGRKIAEGTPEEIRGSEDARVLQFIRGEPEGPIPFNRTEKNYYDDILRVP
>NC_008554.1|WP_011697273.1|482018_483035_-|FAD-dependent-thymidylate-synthase
MSVQFVKTRVQPQGIAPAEEGRALQLVELCGRTAYKSEDKITPDSARNFVLMLKSHGHLSVLEHSNIVLEIEATPSSGATQALSSISELYGALLDGLGFRTAYHRIHLSARTSPGALFIAGNLRSWIETLTHLGNGGSPLHALLSAALRDFFPIIFGGEETVSSNLSFKVTLVREDEQLALLRRDAACDLPVFVFKFVCDRGITHEVVRHRVLSFTQESTRYVNYKNKGMVLILPEELYPFYDDATQQLTGRSPLVDMWIDRAEKLFAWYREDLDREKPEIARDILPNLLKSEIFVSGRWSGWKHFVQLRDSKHAHPRIRAIAKEVRNHFDSLGMTVE
>NC_008554.1|WP_011697272.1|481335_481956_-|hypothetical-protein
MKDIFDRQMQLNIYTLRNIGLDFSTTVADPLEKTVWIENYRKAFSAELAELVREVRERGVGTHNGRIEVVDLLHFLVSLSQIVGVAPSAAFSMMSDGNPGKGGVAGGTAEQAVMECVVETFLALDDLQGCMKWKWWAKGGGFKPDMAEKAVLDLWKRFGEVCALFDLDFDTTKRIYTAKNEVNFRRQDRDYNEDTKDESDNLAIEA
>NC_008554.1|WP_041439600.1|480645_481284_-|dTMP-kinase
MKPISPKFVTFEGIDGCGKSTLIDELASWLDRTRVPYVKTREPGGTSLGEKIRGLLLDPAHRGMNRQTEVLLYTASRAQLVAEIILPALKSGAWVLADRYIDATLAYQGYGRELDPDPLRRLQHWATQALVPDKTVLLDCGIDTAAARMSARNHRPDRIEMEERAFHERVKAGYLDLASLDPGRFIVLDAEKPLPEVIADFRAAFREIVPAP
>NC_008554.1|WP_041439598.1|478112_480464_+|DUF4115-domain-containing-protein
MDDHTEDVYKMREMVESFAQRRAEDEKRAYPRFMTPEGLTGRIDPGNLSGMLLYRKDRPRGQQHGTASDRHGDGPEGHSAPGGDFEKVSDICILDFSEEGAQVYFRCENPFKITQNRLFFQIGASRLPVWLRWYQISREGNTAGFEFAEARERNQDLAHVLVSLSDRLVSFLIGEYLPKAKKDHAQACVYAYLSILYNLRLRFLETVASFYKAQACAEKCVTSRHHREIMGTLFEFESLRTLHFRQARALGGDKPFKATLEFFMKPYRDHQCGLSGRHQKVCFLENDVMNALMDSIVFWNWSIPPPDELNDRIKPVYKSFLALRSHLPGVFDGAEFDRQFIYYSFLIRSVILLKDKLIDVVSSSCPFAGQGRWGEGTAAGTGAGKSGLSVKASDLLGKEEFEEIGTPALERKLTETFGPDADVEPAVVHEARRVSGTWRGFPRMDRYLVMGPLILAICFGIAVLMWSKERPSSEAPVRPERSSLQAEAAPGPPAVGVVPRGAGPAEGAGVSPEPDVHASDDARGTLRRRAIASIPASVPEQALASVPGSGPAPVKEQPSSETTARPERSPLQAEAASVPVAAGVPGLTNTSVPNPAPNERNDSQGNAPDRTASPVPGDTPDGGAGKFAGSTASISGGGQEPKGEAAEPGEEKIAMVGGPQVAMAVPVPSARTSAPEKSKDVAPAAPPGTPLVHDFVVEAIEPSWLQVTIDKGKPWATTLQPGNRFEWKVRDRINLVVGNAGGIRIVWDGQALDPPGNPGQPVRLTLPEPQREPQRKAKSRTRR
>NC_008554.1|WP_011697269.1|476245_477436_+|HD-domain-containing-protein
MIRKGLIDKLFEAASIQRWNDHVRPVEFTELDKQAHKMIIAYVLGKLEEGQRLARIDWRKLIEGGIFEFLHRVILTDIKPPVFHKMMSKKGAEINAHVCRKLEQDVRDIGGDFAEKLKSYLFDRDYSPFEKRLLKAAHYLATNWEFQIIYSAAPFIYGIEKTKEEIENQIEDHYDLIGVQKISLRKKSFGFIDLCGQLRFQQRWAHSPRVPKTSVLGHVLIVAMLCYFLSVEIDACDRRVYNNFFAGLLHDLPEVLTRDIIHPVKRSVEGLEEIVKEYEEIQLEEKILPLLPSSMREEIVYFLQDEFKNKIIDAGAVKKGVSGETMDACNSDAYSPLDGEIIEVCDKLAAFIEASLSIQHGIKSHQLEEGKRFSYENYRDKRVGKLRFGYLFDYYN
>NC_008554.1|WP_041439593.1|475486_476026_+|cation-binding-protein
MKPIGPMMWEHRLIEQMLRVCEKEIEKVKESNKLDVIFIDAVVDFIRTYADRTHHGKEEDILFRDLEKKQLSPEHARIMKELVDEHVHSRETVKQLVEAKERYLRGEGTAREVVAHLEALARFYPLHIEKEDKHFFHPCMEYFTKEEQDRMLAEFYEFDRKMIHEKYRDVVERMEARGA
>NC_008554.1|WP_011697266.1|473730_475044_+|(Fe-S)-binding-protein
MRSMKHLALLLREVEDQLVVCMRCGMCQSVCPLFAETGRESDVARGKLALLDGLMQEMFKDPAGVSDRLNRCLLCGSCAANCPSGVRVLDIFIKARAILGGYMGLSPLKKLLFRQMLARPALFDRIVEMGSRFQSLFIRSVDDLLGTSCARFQSPLGERHFKALAAVPLHVRTPALNAPAGGSGIKVGVFVGCLVDKVFPEVGEAVLKVLRHHEVGVFMPDGQACCGIPALSSGDLESYRALVRHNLSRFAPGEFDHLITPCATCTSTIRKIWPLMAGDLSAEERERVRLLSEKTLDVSQFLVDVLHAALAEGAEETGERRLITYHDPCHLRKSLGVYAQPRSLIRANPRYAFREMAEPDRCCGCGGSFNLQHYELSAAIGRRKRDNIAASGCSEVATGCPACMLQLSDMLSRAGDRVRVRHVVEVYAEALDDNRQS
>NC_008554.1|WP_011697265.1|472345_473728_+|FAD-binding-protein
MIGRALIAEFEKLLGRDNVFADEADRHTYSYDAAVLDPVLPALVVRPTSSEGLGRSVRLCGENALPVTVRGAGTNLSGGTIPARGGVVIVTNGLNRILEINEADLYAVVEPGVVTARFAAAVESRGLFYPPDPGSQAVSTLGGNVAENAGGLRGLKYGVTGDYVLGLSFFDANGEIVKTGARTVKCVAGYNLAGLMVGSEGTLGVFDRIILKLIPIPAARKAMLAVFDDIAKACEAVSGIIADKIVPATLELMDNFTIRAVEDYGHAGLPVDAAALLLIEVDGHAAQVEEDASRVEAVCRGRGAMSLRVARTAAERDKVWEARRAALSALAKLKPTVVLEDATVPRSKIPAMMNSLEAIASRYRLTIGTFGHAGDGNLHPTILTDRRDRAEWSRVEAAIDAIFDEALKLGGTLSGEHGIGLAKSRFLEKETSRATILYSRRIKTALDPKNILNPGKIIGE
>NC_008554.1|WP_011697276.1|485216_485657_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD
MYRPSLEITVGVFFILGVVCMAYLSLVVGGPGALGEPHYRVNALFNSITGLRRGAAVEIAGVRVGKVLDITLENNQARVVMAIRDGVRLSDDTVASIRTKGIIGEIFVKLIPGGSGRDIGPGDTLIETESAISIEELIGKYMFEKK
>NC_008554.1|WP_011697277.1|485787_486393_+|ABC-transporter-substrate-binding-protein
MVGKMVIALLLAASLFIAAPASAGEPMEQLRVSVEKVVEILKDPSLKSPDRMLERRNRIFKVVEERFDFSEMAKRCLGEFWPKISEAEQREFEVAFASLLETSYIATIERFDEESVVFEEERPKGRQYFVVHTAVVSGGRSISVDYSVRNVNGQWLVYDVNIEEVSLVAGYRVRFAETFRREGFRGLMKKIAEEAGGPGKG
>NC_008554.1|WP_011697278.1|486486_487233_+|acetylpolyamine-aminohydrolase
MKVVTHEDFKQVYTHEPAAAPGRIEAILGAIRDEAVFEDAYPAGAEDIAAIHSKSHIQSVTHQGLYNIACLAAGGAIQTALTGLKEPCFGLIRPPGHHASADSYWGFCYFNNMAVALDHLKRNGHIKTAYVLDFDMHYGDGTVNILKPKGYVAIHNPESHDRKEYLSDVSRHLESAAADIIAVSAGFDNHVQDWGGVLLTEDYQAMGRMVHDTAKRLQVGCFGLLEGGYNHQVLGENVRAFLRGLSGS
>NC_008554.1|WP_011697279.1|487329_488166_+|rhodanese-domain-containing-protein
MTAGSGSGDVKSLYPDEAKEFIDEHKEGTYLLLDVRQPTEYEQGHLPGAQLIPLPSLPDSIGGLDRKRPVLVYCAVGGRSATAASFLAHHGFSEVYQLLGGIQAWEQPTAANPVKFHLEFASGRESPREAVLLAYAMEQGMLDFHEAVRVRTTEPDLADLLVKLVRAEESHKKTLRELLRQHAPDEPPPEDVPGGSSRIMEGGLDIQDFMKQNESFMKTTAGYLDIAMMVESQALDLYLRMGAASSNEKTRRILFHIADEEKAHLSMLAELLEKKMSA
>NC_008554.1|WP_041439602.1|488458_488872_-|PIN-domain-containing-protein
MKVFFDTSAFVKRYVEEPGTEKVLEICDKADQLVLCVICLPEMISTLNRLVREGRLQNDEYRKLRDLVLEEIEDAEICFLTPEVVAQTIKCLESNVLRAMDALHLGCALVVEPDLFVSSDRRQLEAARRAGLKVMEA
>NC_008554.1|WP_041439604.1|488868_489096_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MRETNVVELRKRIKHYFDAVESGEVVRVYRNGKPIAEILPLTKREAPWKREGPRLTVPGLSLSREILKDRAESDT
>NC_008554.1|WP_011697281.1|489219_490572_-|hypothetical-protein
MRQSERANPYLGTIAAALFVFSVLCCGAARAGGTDEGRAILVDAHGNVYVCAKSWRSSDQQFGIVTMKYSSSGKRLWARRFTDINNNGTWGQGSVALDGNGNFYLTGQTLDRKLLVLKYTPAGSPVVSKYSFGGIPVGSGSNGRAIHVTPDGKGIYVTGEYWNSSNSTWDIVTARLGPDPDMEWTTRRIASKHQFARAMVVGTNGNVTVTGQNFDAEADTYDYLTIKYNALGKIEWAKTYNKGTWDEPFSVAVDPGGNAIVTGSAGSAEATRDFVTVKYSPGGVQSPAWIYDGAAHALDYAETVKTDANGNVYVAGTSSGAYNWDIVLLKYNSSGQKVWTRSYSNLCNDFFDEMALDKNGNIYVAGHSGSGGSGTWDYLTMKYNPNGKRAWTKFFNSSHNSADMALSLTVDGSANVYVTGKSYNGTDYDCLTVKYDTNGNLVWSRRYDSA
>NC_008554.1|WP_011697282.1|491263_491563_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MPLVRVIRNGQITIPKKLRATLGIEEGDLLEVKLSQGGMTIKPKTAVDKELSKGRFFRMVEEIRESVKDADPREVDAALAEAVRAAGKATSKKMKPRRS
>NC_008554.1|WP_150109408.1|491932_492418_-|hypothetical-protein
MKSEHNEELLKFTYNYQKSELEYRRNREHQIFSWTASILLAIIAALFFKSPSTEILFKTQNIAWRLLFSIVVIGLTIYSIGWQHYHNTKAASHKKLIISIIDKLKLFDGNSPILSSKWRSWGTEYVGFRGQHKYPSKMSATAFLGIVGLLAIWIDFILKMN
>NC_008554.1|WP_011697283.1|492633_496077_-|N-6-DNA-methylase
MDKQQARKLIKQTFEQPFEKTRFTTLIKNLLNRCEEAPLSYKGQYIPDAYKPYISALDRIGKFHDGEHAVDILVIKLKKETSLERARTMQRNFVAWYLNGSRGDKLKDAALVAFVSPEETDWRFSLVKMDYRFEQTKTGKMKVKEEFTPARRWSFLVGTNEQSHTAQSRLINLLANDEQTPTLAELEEAFNIETVTTEFFLKYRDLFIRTKEALDRVVRGDPRIEAEFEAKQVNTVDFAKKLLGQIVFLYFLQKKGWFGVGRDAPWGTGSRQFLRELFEQKHGRYGNFFDDILEPLFYEALRNDRSHDDDYYSRFNCKIPFLNGGLFDPIDDYDWVHTNINLPDSLFSNQNRTAEGDIGDGILDIFDRYNFTVKEDEPLEKEVAIDPELLGKAYEKFNAIRPDNFEEYKQVLRSGKKGDENKFNKQFGVYYTPREIVHYMCRQSLINYLHTELGKDIVTHKKLFEKQTTMFGNQAKRGQLDCTIEYKLTPQISRKDIETLIHLGEQVSANEARVENKGKETVTYSYKLPESIRKNAGPIDRKLADITVCDPAVGSGAFPVGMMTEIVRTRNVLSTFIQEDKPTPYDLKRRCIEHSLYGVDIDAGAVEIAKLRLWLSLIVDEDDIKNIKPLPNLEYKIVCGDSLLGYPYKPMGLDEVEKLKEQFLEEVNPKRKKELRNRIDAAIYGLFKNTEKSLGYQVTMDFRTNFSEVFRTKGGFDVVVANPPYVRQEAIRHLKPKFKKIFKDFYCGTADIYTYFYKCGVDLLKSNGHLCFIAPNKFMRASYGKNTRTLLTTRATPRLVIDFGDLPIFDATTYPSILLIEKRKPDGRDKAVTATFTDASQLAKLEDSLLDIAFLMPVKALSKEGWNLERSDVLSLMEKLKKIGVPLGEYIQGRFYRGVLTGLNKAFVIDAATRERLIAEDPASADVIKPWLRGRDIRKWKAEWAGLYVINIASSSNKTWPWSNVKTEAEAVRQFEETYPAIYRHLAPWEKELQKRDDQGKFWWELRSCAYYEAFEGTKIIYPDISQASKFSWDQSNSYLGNTVYMIPTDKLWLVGLLNSKFIWWYYSNITSTIRGGFVRFFSQYMETIPISLISDSQKTSIIERTRAILAAPGSPAVPTLEAEIDQIVYVLYNLTPEEIRIVEGVN

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Crispr_ID: NC_008554_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_4

644020-644237

Orphan

Consensus_repeat	Method
TATGCCTGCAATCGGCCCGCGCGCGGATACGTCA	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_008554_4

>merge|NC_008554|4|644020-644237|CRISPRCasFinder
TACCCCTGCAAGCTGTGCGCGCGCGGGTACATCGGCGGTATGCATCAGGGCAGCGCACGGTTAGGCCTGCAAGCTGCGCGCGCGCGGGTACATCGCGATATGATCAGATTCACACCGAAACGGTATGCCTGCAATCGGCCCGCGCGCGGATACGTCATTGGAAATATAATTGGAATGCTGCATATATGACTGCAATCGGCCCGCGCGCGGATACGTCA

>NC_008554|4|4|644020-644237|CRISPRCasFinder
TACCCCTGCAAGCTGTGCGCGCGCGGGTACATCG	GCGGTATGCATCAGGGCAGCGCACGGT
TAGGCCTGCAAGCTGCGCGCGCGCGGGTACATCG	CGATATGATCAGATTCACACCGAAACGG
TATGCCTGCAATCGGCCCGCGCGCGGATACGTCA	TTGGAAATATAATTGGAATGCTGCATA
TATGACTGCAATCGGCCCGCGCGCGGATACGTCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_150109416.1\|642527_643082_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697395.1\|632093_632930_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_008554.1\|WP_011697393.1\|630709_631516_-\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|224790
NC_008554.1\|WP_011697407.1\|653890_655063_+\|DUF1343-domain-containing-protein	unknown	unknown	gnl\|CDD\|377768
NC_008554.1\|WP_011697392.1\|629405_630530_+\|glycerol-dehydrogenase	unknown	unknown	gnl\|CDD\|341449
NC_008554.1\|WP_011697408.1\|655345_656011_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_008554.1\|WP_083763919.1\|635134_638542_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|224437
NC_008554.1\|WP_011697410.1\|657209_657797_+\|PilN-domain-containing-protein	unknown	unknown	gnl\|CDD\|377469
NC_008554.1\|WP_011697397.1\|640254_640746_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|222904
NC_008554.1\|WP_011697402.1\|644553_647721_+\|polysaccharide-export-protein	unknown	unknown	gnl\|CDD\|224512
NC_008554.1\|WP_011697401.1\|643229_643544_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_167321305.1\|640782_641388_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271177
NC_008554.1\|WP_011697396.1\|633700_634444_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381615
NC_008554.1\|WP_011697405.1\|650092_651862_-\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|341073
NC_008554.1\|WP_011697403.1\|647800_648775_+\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|133044
NC_008554.1\|WP_167321307.1\|657835_658423_+\|type-4a-pilus-biogenesis-protein-PilO	unknown	unknown	gnl\|CDD\|309474
NC_008554.1\|WP_011697404.1\|648778_649861_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|225719
NC_008554.1\|WP_167321306.1\|641428_642571_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|225412
NC_008554.1\|WP_041439690.1\|651974_653375_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NC_008554.1\|WP_011697409.1\|656160_657213_+\|type-IV-pilus-assembly-protein-PilM	unknown	unknown	gnl\|CDD\|378558

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011697395.1\|632093_632930_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.44754e-56
NC_008554.1\|WP_011697410.1\|657209_657797_+\|PilN-domain-containing-protein	gnl\|CDD\|377469	pfam05137, PilN, Fimbrial assembly protein (PilN).	7.06603e-17
NC_008554.1\|WP_011697393.1\|630709_631516_-\|cyclase-family-protein	gnl\|CDD\|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	2.87158e-56
NC_008554.1\|WP_011697407.1\|653890_655063_+\|DUF1343-domain-containing-protein	gnl\|CDD\|377768	pfam07075, DUF1343, Protein of unknown function (DUF1343). This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.	0
NC_008554.1\|WP_011697392.1\|629405_630530_+\|glycerol-dehydrogenase	gnl\|CDD\|341449	cd08170, GlyDH, Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation. Glycerol dehydrogenases (GlyDH) is a key enzyme in the glycerol dissimilation pathway. In anaerobic conditions, many microorganisms utilize glycerol as a source of carbon through coupled oxidative and reductive pathways. One of the pathways involves the oxidation of glycerol to dihydroxyacetone with the reduction of NAD+ to NADH catalyzed by glycerol dehydrogenases. Dihydroxyacetone is then phosphorylated by dihydroxyacetone kinase and enters the glycolytic pathway for further degradation. The activity of GlyDH is zinc-dependent; the zinc ion plays a role in stabilizing an alkoxide intermediate at the active site.	0
NC_008554.1\|WP_011697408.1\|655345_656011_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	6.57274e-52
NC_008554.1\|WP_083763919.1\|635134_638542_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|224437	COG1520, COG1520, FOG: WD40-like repeat [Function unknown].	5.5865e-19
NC_008554.1\|WP_011697397.1\|640254_640746_+\|hypothetical-protein	gnl\|CDD\|222904	PHA02601, int, integrase; Provisional.	0.000619403
NC_008554.1\|WP_011697402.1\|644553_647721_+\|polysaccharide-export-protein	gnl\|CDD\|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	1.58446e-22
NC_008554.1\|WP_167321306.1\|641428_642571_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	7.36735e-12
NC_008554.1\|WP_167321305.1\|640782_641388_+\|site-specific-integrase	gnl\|CDD\|271177	cd00796, INT_Rci_Hp1_C, Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain. Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	3.44352e-31
NC_008554.1\|WP_011697396.1\|633700_634444_+\|hypothetical-protein	gnl\|CDD\|381615	cd16894, MltD-like, Membrane-bound lytic murein transglycosylase D and similar proteins. Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	2.96322e-24
NC_008554.1\|WP_011697405.1\|650092_651862_-\|M3-family-oligoendopeptidase	gnl\|CDD\|341073	cd09610, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and is similar to oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NC_008554.1\|WP_011697403.1\|647800_648775_+\|NTP-transferase-domain-containing-protein	gnl\|CDD\|133044	cd06422, NTP_transferase_like_1, NTP_transferase_like_1 is a member of the nucleotidyl transferase family. This is a subfamily of nucleotidyl transferases. Nucleotidyl transferases transfer nucleotides onto phosphosugars. The activated sugars are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides. Other subfamilies of nucleotidyl transferases include Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase.	9.22334e-70
NC_008554.1\|WP_167321307.1\|657835_658423_+\|type-4a-pilus-biogenesis-protein-PilO	gnl\|CDD\|309474	pfam04350, PilO, Pilus assembly protein, PilO. PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.	1.61408e-48
NC_008554.1\|WP_011697404.1\|648778_649861_+\|phosphotransferase	gnl\|CDD\|225719	COG3178, COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only].	4.27519e-27
NC_008554.1\|WP_041439690.1\|651974_653375_-\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	6.80215e-161
NC_008554.1\|WP_011697409.1\|656160_657213_+\|type-IV-pilus-assembly-protein-PilM	gnl\|CDD\|378558	pfam11104, PilM_2, Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis. It binds to PilN and ATP.	4.60034e-87

>NC_008554.1|WP_011697401.1|643229_643544_+|hypothetical-protein
MRTFRDHLQEKLQDKRFGELFDEEKELVRIGIEVAEARAKLGMSQADLQMHREIRPPAGSESFLYMPASIKKENGPKTVLEKATASDVPSEVLARFQKSPSKAS
>NC_008554.1|WP_150109416.1|642527_643082_+|hypothetical-protein
MKKTTPAKQKCVLLDACIIIEAFNLGVWESLIERAEVLVSSIVAHEETLFHVKGQLPEPINMKRLIAEGKVQEFAATASQMAGLRLCFDRRFVEGLHEGELEALALIHENLVGEALYSSGDANAIRALAMLGHSDRGISMERLLKTTGLQKTVAPQFGDSLFRRCIGEGKQSRITGEGLNKSIV
>NC_008554.1|WP_167321306.1|641428_642571_+|ImmA/IrrE-family-metallo-endopeptidase
MSGSIQEAIGRRIQELRKRLGMNQTTLAEKMGFGSAETISSIERGDREIKAVEIAQLSRILLVPVADLLMPVEAEPDPSILWRAEPMQGREVTEARFLQRCNQYAWLEEAVGVTRLARFPSLEVDPERVNLSDATRLADEVRRQFDLGNRPAAVLEKTLEDVYGVKIWYDKLEEGSAASVWGKFGPAILMNSREAPWRRNYNFAHEVFHLITWNSLPPGLLSEQSDLRSKVESIANAFASQLLLPADPVRMVFYARVTESKIAYSDLVDLARSFDVSTEALLYRLLNLNCFPRAAVTKMLRDPAFRELDRCSMSECWHSPPEIPERFVRLAFLAHQKGKLSRSKFASLLGASIADLNDVLRKYGFGDEKDNAGKTKVRVA
>NC_008554.1|WP_167321305.1|640782_641388_+|site-specific-integrase
MFTGCRRGELFKMKWGDVDVERKILTLRAPKGGKTEIIPLSDTTLSAIEDLARKSEYVFPGREGAMLTGFKGPWEMVRKEAKLPASFHFHGIRHSFASNLVSSGVDFYTVGGLRTHKQAVTTQRYAHLSDEAMRRAVEKSAEVITPKEKKEEAVENDIESAQRAYYGQQKTLLLFIENLMADLMRKQFQEKLEKIKKYATI
>NC_008554.1|WP_011697397.1|640254_640746_+|hypothetical-protein
MVDNLTMARKVEGAIKGDLARVEYDIADHKAAEKVTLNVSFDNHFLPWTKEHKRTWRNDRYLYDCHLKPRFVGKALEEINAFEINKMKLAMKKAKNKQGRPCTPATIKHVVVLLKRLFNLATRWRIHKGANPCAGVELPKLDNKVTEFLSDEKTERLLKVLDA
>NC_008554.1|WP_083763919.1|635134_638542_-|PQQ-binding-like-beta-propeller-repeat-protein
MRNTESIGHSSLLKMITFNFSARLRNSIFGCLLFWAVLLCFSHPVLAGAEETPAWSFETGGPIKSSPAIGTDGMVYVQSSDGSLYAIKPDGNVKWSVGIEGHPNLSPAVGDDGTAYSAGAGNLLHAINHDGTPKWFIDIGGAPTSSPAMGADGSVIITEGANILSINPDGTHKWIFSPGSRIQAVPAIGKDGMVYAVTENAVLYAIDGYGIARWCFELKSKQMNCSSTLDPDNTIFILFDRILYAVNTTGCIQWSLDKILSSSAPGTDGIVYVTADSRICAAGFNGTLKWSFPISDRLDSAPPPAVGFDGRIYLGRRDGRIDAIGLDGNQVGFFDLHQQIDAPGVVGPDGTLYVGSEDSRLYAIKSRSSTKPELAGQERESPIPGITGSAASWTGAVRGVLHQNSATGPVLAGVTVTCGGKTTTTSSTGAYVLTGIWQGRQVLSFSRNGFQEKSRLILITAGQTLNAGNDFLVKTPTGTARGVLHRNSATGAALAGATVTCGGKTTTTSSTGAYSLTGIPEGRQVLSFSRNGFQGKCKWVLIPARQTLNAGNDFLVSAATNYLTLVKQISTKYRAKAGTTISDKIDATVRPPAKATAGADLAAFFLSAGAGSAAIYSAAWSAMKNPNDAIAANTLAVALDGMGDSDSALKILLYADGIKPNLPVIALDLGWVYLHKGNIKNATLYFNKALALSPGLSSAKLGLGLIAESQGHHKTAQTNLIAALTTSVSAFGASQLHAAEQAISDSGGAERTDPISNKTASDSTTVIPPIQIASGISGQDSLSSIASSAQKFENAYARLNNSISTASQEFEALAIKVNEEAQSMVQINTDGIKEYFMFDKEHFLMTDIQDIINHKSTILVNAYMDWWATENENYMQADSTLINQETAEIYACNYDETCEAQVRYKYCMKKNNLGKTHFLADANKIASTSKSMASVLTKFSALARPIIKKIQWPTLNQFENKFLQLNTLNLYYFLSAAAKNCTEGALNLVNSLYLCVPPPEPDTSATDDPSIGRSATKWCPFKDAPLKLNLIVFSYELACDHVKIGGTYNFITGSIKRDFLKHQTEVFIGAGAVVSYGNGAIGGNAAVGVVFTVAAGQVQDIGLSSTVSTSLGGVYSASVNGRIGVNSGPSITGPF
>NC_008554.1|WP_011697396.1|633700_634444_+|hypothetical-protein
MQDCSKPRRLVYLVAALFMAAGVIGCATAETSAPAGPPVQAAVQAERTAAPVQVQRPAHQSPGMVAYYPPPGRMDFCGEHVPLENQEVMERFDKEFTLVVYNHAQIYRWLKRRDGYFQWMEERLRRLNLPEDLKYVALAESEPPLSTADRKRWAEMRNDFERSPESALQYLGDLHRSFRSWSLALAAYCCGEKRIMDESRAQGQSDFYKMMLPQETERYVFKVLAIKAVLSDPARYGYELPKGARQR
>NC_008554.1|WP_011697395.1|632093_632930_+|SDR-family-oxidoreductase
MSEPFKGKVCIITGSSSGIGLGLAKELLGRGAVVHMSGWRETNRENLRTTADLLERYPGKAFSRELDVRDARAVAEYIADIAAGGPVDYMFSNAGVGLEMPFIGVDLAVWDKILGVDLYGVIHCVQAVVPLMLEQGHGHIVNTASVAGIVPLPYQAVYCAAKYAVVGFSESLRYELEPYNIKVTAVCPGAVATQIFQRGLDYTVHEELPMPEEAIGIDHAALEILEGVEAGRGILPVTDFARAMYENIRTDPARNDVVMRSIARDRRQRFIDRGLLDR
>NC_008554.1|WP_011697393.1|630709_631516_-|cyclase-family-protein
MQLDTRFSFFAAAIVSLILLAAPTTSSAASEEKLVDMTFPFSEESIYWPTDKPFTPTVVFKGITDGGWWYASNQYAASEHGGTHVDAPIHFHEHGRTIGQVPLQEWIGPAVKIDVTGKSLANRDYQLSVEDLLAWEKKHGPIPQGAWVIMYSGIDDRFYPNRKEVLGTDKTGMDAVAELHFPGFSPEAVDFLLANRAITGIAVDTPSIDPGSSKDFKAHRALCKAQKLALENIANLDKIPESGAMLYVIPMFIQNGTGAPARVFAKLP
>NC_008554.1|WP_011697392.1|629405_630530_+|glycerol-dehydrogenase
MFSVFSSPARYTQGLDATAILGAEMAGLGIEGPALIVAGGSALAQLSGTWRQTLGEVGCSYGIHRFGGECSLAEILRIRHAAEALPARVVIGAGGGKALDAARASAAELGLPFVSCPTLASTDAPCSAVSVVYGESGAVEEVRILPRNPVLVLVDTRVIVQAPPRLLISGMGDALATWFEARACAASGARNLRGGRSTRSALALAELCYRTLLEDGVEAVEAAGTQTVTPAFERIVEANTLLSGLGFESSGLAAAHSVHNGLTAAPQTRAFTHGEKVAFGTLVQLVLEKSDRSAIDEVMGFCAQVGLPVTLAQIGLRELSGEMLERIALRATRTGESIHNEPFEVSANRVADAILKADALGRALPGNGKLPSPE
>NC_008554.1|WP_011697402.1|644553_647721_+|polysaccharide-export-protein
MRSKRKMFCATLLSFLLCWNSVCAQQLQQIPSPLAPPFATTSTPVSATTGSSPTTTTIPGIPGLPSLTLPQAMMPVPCETLLPGQLPPVGTPPVIPGLPSTAGQVPYLQPCGPGQIPYQPPGVATQVPYQAPGIPSQVPYQPPQGTAAQGPYQPAPGVAGQALVTQPGVGTSQVPYQQPGVPVQGAPVTQPGVAGQVPYQPSAIPGQVPSLQPGVSLQMPVQQPMVPGQPGYPQPTPPTSRGYQAGQVPYQQPAELAVPPILPVEPLSPFEEFVAGKSTSTPASISFDIKQFGYDLFINSGSPLITGSPISGTAVPGTTGVPGMLGGTSVQTIPGMPGIPGTTGHTGPMSTQFGLPILNVPVSPSYVIGPGDEIRIAVWGSVEGTWDVIVDRDGTISLPKIGIIGVTNMTFQEVKDTLKNEFSKYYQDFQMNVSMGSLKTIRVYVVGNARNPGAYLVTSMSSIVNGLLAAGGPSKAGSMRNIELKRNGDTIAVFDLYELLLKGDKTKDRQLMAEDVLYIPPIGSMVGVAGNVERPAIFEMKGKTKLSEAIKMAGGPTADAYLQRIQVERVSQRKAKIFLDVDMQGIKGKQDIVLQDGDIVKVFPISMFVTNRIILKGNVRRPGEYEWKHGMRVKDIIRNFDALLPDAMLEYALVERLVAPDNHQEYRTFNLREAISGTDRSQNILLEPYDTITVYSKWEMQERERVRVSGAVNRPGDFEFRENMKLSDLLKLSGGLKKTAAADNAEITRVVPTEAGPRTEQIQVNPTLALAGDPDFDILLHRDDYLTVKSVPDWQLYRKVSIYGEVKYPGDYALQKGERLSSLLERAGGFTDRAYKRGSSLFRESVRQLQQRQMGELIDMLGRQVLANSAANLMGEMTPGEAEFQATQAKQQKLFLDTLRTLQAKGRVVVQLDEPRKLKGTAFDIEVEEGDQIYIPINPRVVQVIGAVYNQTAFVYEPGRNYSYYIDQAGGYSPTADKGNVFILKADGSAVQPGRGIFWCVATARWQTGANGRLEPGDTVIVPDKLDKVAWMRNFKDLTTVLYQIAVGTGVLLRL
>NC_008554.1|WP_011697403.1|647800_648775_+|NTP-transferase-domain-containing-protein
MKAMILAAGLGTRLRPLTLARPKVLVPLMGTTVLDFWMWRLRDAGACAAVVNAHHLGEKLVSTVAENTWPIPLESRFEPVLLGTGGGLRNALDFLGTEPALVINGDIVCDVPLRELPRKHSEHGGPVSLLLHDCPRFNNVAVDENDRILGFGSEASELKRSLPNVRLLAFTGIHCIDPSILSVLPPDRFSDILALYRELIRAGRHPRAIRRPRVFWREMGSIRAYRDLTVELAGMPEDFLPPLHCGSRVRIDPRAFVDPRAELRGVVTVGKGCVVMEGAVLEDVILWDNVTVEPGSRLRGCIATDGSVVGGIHEDEIFTGPRQG
>NC_008554.1|WP_011697404.1|648778_649861_+|phosphotransferase
MPTIMLPELRPMLHHAAGALRLPLDSADVTPLAGDGSDRRFFRVRRGADHYVALISPRKNHQGLDENDSYLKIGEHLHRRGVPVPRIFWADAARGWFLLEDFGDRHLQAQVLRGRSSVTAVYRKALEVLVRLHREGRDGFRADYCFDGAFYDPAFVYERELEYFRSAFLVSLMRLQIDREDLRSDFERIAEAAGTGSDRFVFHRDFQSRNLMVCKGKLGLVDFQGMRFGPPAYDLASLLIDPYVALPARLQEVLCRLYWDDARKFLGGSIDAFLKHYRWVRLCRNLQILGAFGYLGTSKGKTRFLAYVPGAWAELTRLLREHFAGCFPRLEECVETVAREAAFTFPTGGAQVFRDFAAAN
>NC_008554.1|WP_011697405.1|650092_651862_-|M3-family-oligoendopeptidase
MNDPAEHVVWNLNDLYSGPDAPAMEQDRQSANDLAVQFAARYRGKVAALSPEEASAAIREYEALQEILQKLDAYAALHFATRTRDPSTGALLQAIREFRSQVHRDTLFFELEWAQIDDEAFAAALRHSALGPYRHYLELSRRYRPHLLTEPEEKILAEKEPVANDSWTTLFDKVLGHLRFGPGERTESEVLSDLYAGDRTVRQQAARELTQGLTEMLPVLTHIFNTILLDKAVTDRLRRYPHWLRARNLANEAEDVMVEALVEAVSSRYDVVRRYYRLKRTLLGYEELFDYDRYAPIPGLPKKAFSWEEAKHLVLSGFEAFSPEFAEIASDFFRHNWIHAPVLPGKRSGAFSHPTVPSCHPYVLVNFTGTSRDVATLAHELGHGVHQVLARKQGLLNADTPLTLAETASVFGEMIVFRHLLERVESRKERAALLCSKLEDSFATVFRQVSMNRFESAVHNQRRSGGELDPERISQFWLDSQKQMFGDSVTLTGDYRIWWSYIPHFIHSPGYVYAYAFGELLVLSLYRQYRQTGASFVPLFRDLLEAGGKASPNELLSPFGIDLSDPSFWKRGLEVIEGMLDEAEQYARS
>NC_008554.1|WP_041439690.1|651974_653375_-|FAD-binding-protein
MAMTIPITEITRIVGKDHVLTAPEELHCYGYDASKMKARPECVVFPGSAAETAELLVLANRDRFPVYPRGAGTGMVGAAIPSGGGLVVALNRLNRILEIDAENMTAIVEPAVVTGDFQKRVLECGLFYPPDPASLQFSTLGGNVAMCAGGPRAVKYGVTRDYVLGLEVVLPTGSIIRTGTRTMKGVVGYDLTRLMVGSEGTLGIFTKIILRLIPAPEGVRTMMAVFPRLDDAANAVCDIIKHRIVPSTLEFMDQPTIGVVENYLHAGLPTEAEAILLIEADGREALLDEDASQIERLCREAGADAFKTGRSPAEREQLWKARRAISPALGQIRPGKINEDVTVPRTLIPSLIRFIQGLASRHRLTIVCFGHLGDGNIHTNIMLDRKDADERKRAERAVEELFRKVLELGGTLSGEHGIGIAKSPFLELEVGRDGLAAMLRIKQALDPLNILNPGKMFVPNRAFFGE
>NC_008554.1|WP_011697407.1|653890_655063_+|DUF1343-domain-containing-protein
MGKVILGCEVLASSPPGWFRSGRLGLLVNQASVTQSFEHVRDLLRRTGGRLTCLLSPQHGFHSEKQANMIESDDSWDEDSSLPVVSLYGKVRQPSRETLDGIDVLVIDLQDVGTRVYTYGVTMGLCLEAAARSGTKVVVLDRPNPIGGISIEGNILDDGYRSFVGRYPIPMRHGLTMGELARFICKECSVDCDLQVIPMKGWRRRDYFPDTGLPWFFPSPNMPTWETALLYPGMVLLEGTNVSEGRGTTLPFHVFGAPFVNRRRLGDYLAGAGLEGVVFRPVSFEPMFDKWRGRLCHGFQIHVTDRVSFSPYRLGLTLIRGLRLLNPDEFKWLEPPYEYETEKLPIDILLGDGKLREKLDNGADPGGVARGWANPLAAYWAKCAGLFLYA
>NC_008554.1|WP_011697408.1|655345_656011_-|signal-peptidase-I
MRNPPEKNTGSKRTKSLLREYTEAIGIAILLALFIRAFVVQAFKIPSGSMKTTLLIGDHILVNKFVYGIRLPILNKEILHFSNPKRRDIIVFQYPVDPSKDFIKRVIGEPGDTVKIIDKKVYVNDQPLDEPYTVFTDPKIQPAGVSPRDNMGPVAVPPDSLFVMGDNRDESYDSRFWKFVKLDALRGEAFIIYCSWNQDGELSLSSSESYIRWNRIGKLLH
>NC_008554.1|WP_011697409.1|656160_657213_+|type-IV-pilus-assembly-protein-PilM
MFAKKENLLGLDIGSHSVKLTQLKAKEGRLTLANVGLVPVPREAFNEGRVNKPDLVSNCIKHLTSHLKVKERTVATAVSGYEVMIKKIELPTMTEEELDSRMHAELGQYIPYNIEEVDVDYQVLDVAKDRPNYMGVLLVAAKKESIGDCVGIVRAAGLDTDVVDVDFFALSNAFEATYGSFEGNIALIDIGSAKAIMNIASNGVPVFTRGISIGGSQITESIRDYFKVSYEEAERLKLGEISVNFPVKEIEGLFVSTVRNWVSECKRAIDFYYSNYPDKTIQRIFLSGGSCRIPGLDRVFQENMGVAVEIFNPFKRVDCDPKLFDPEYIEFIGPQMAISLGLALRKTKEK
>NC_008554.1|WP_011697410.1|657209_657797_+|PilN-domain-containing-protein
MIQINLLPVRAKKKRETARQFVSIYFLSIILMAIALGAAWFLKDREIQDKKAELSRLQQEVAKYAKFEEMLKDLTKKKELVDKKRTIIRDLQQDRDTIVRVLALLSVQLPPERMWFDRLSQVGTTITLDGTAMSNEALVEFMRNLESSPYIEKGSVNLIHSRQTVIAQKKLREFQLSYRFFPFSEVKKRLATKPS
>NC_008554.1|WP_167321307.1|657835_658423_+|type-4a-pilus-biogenesis-protein-PilO
MAGLPLAQKALLFLITLAILGAGFYYLVYEDQEKELAKVTASVAEQQKKLASLKEAAARVDKLQKELAASEADFNSLLALLPDQKEIPGLLESVSQLGAKVGLENVLFQPQPEQPKEFYSVIPIRLDLLGSFNDLEVFLDNVSKLNRILKVETLTLNRVKDKGSGSGLQVGCTIVTYRFVDRPVQKDAKKDQKKK

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Crispr_ID: NC_008554_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_5

806762-806871

Orphan

Consensus_repeat	Method
GGGACGTATCCGCCCTGCGCAACGTGACGACAACGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_5

>merge|NC_008554|5|806762-806871|CRISPRCasFinder
GGGACGTATCCGCCCTGCGCAACGTGACGACAACGACCTGCAAATACCGGGAACTGTGTCTCCCGGTGACGAGGGACGTATCCGCCCTGCGCAACGTGACGACAACGACC

>NC_008554|5|5|806762-806871|CRISPRCasFinder
GGGACGTATCCGCCCTGCGCAACGTGACGACAACGACC	TGCAAATACCGGGAACTGTGTCTCCCGGTGACGA
GGGACGTATCCGCCCTGCGCAACGTGACGACAACGACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_167321309.1\|800642_800795_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153228
NC_008554.1\|WP_011697534.1\|796445_797180_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697552.1\|826584_827061_-\|dCMP-deaminase-family-protein	unknown	unknown	gnl\|CDD\|238613
NC_008554.1\|WP_011697549.1\|821140_822802_+\|pyruvate-carboxylase	unknown	unknown	gnl\|CDD\|163675
NC_008554.1\|WP_011697533.1\|795468_796212_+\|creatininase-family-protein	unknown	unknown	gnl\|CDD\|376872
NC_008554.1\|WP_011697532.1\|794076_795390_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|181000
NC_008554.1\|WP_011697548.1\|819577_821011_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|237263
NC_008554.1\|WP_011697539.1\|801623_802547_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_008554.1\|WP_011697535.1\|797263_797998_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_049766272.1\|798502_800599_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223896
NC_008554.1\|WP_011697545.1\|812575_815308_-\|glucosidase	unknown	unknown	gnl\|CDD\|367389
NC_008554.1\|WP_011697531.1\|792814_793795_-\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_008554.1\|WP_011697551.1\|823882_826549_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341408
NC_008554.1\|WP_011697542.1\|807225_810300_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236140
NC_008554.1\|WP_167321310.1\|816525_818622_+\|beta-lactamase-family-protein	unknown	unknown	gnl\|CDD\|365903
NC_008554.1\|WP_011697550.1\|822985_823870_+\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|274043
NC_008554.1\|WP_011697538.1\|800838_801627_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130358
NC_008554.1\|WP_083764180.1\|803438_804551_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226702
NC_008554.1\|WP_011697547.1\|819102_819366_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_083763930.1\|811509_812217_+\|DUF1566-domain-containing-protein	unknown	unknown	gnl\|CDD\|377878

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_167321309.1\|800642_800795_-\|hypothetical-protein	gnl\|CDD\|153228	cd03134, GATase1_PfpI_like, A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. This group includes proteins similar to PfpI from P. furiosus. and PH1704 from Pyrococcus horikoshii. These enzymes are ATP-independent intracellular proteases and may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For PH1704, it is believed that this Cys together with a different His in one monomer and Glu (from an adjacent monomer) forms a different catalytic triad from the typical GATase1domain. PfpI is homooligomeric. Protease activity is only found for oligomeric forms of PH1704.	1.3482e-08
NC_008554.1\|WP_011697551.1\|823882_826549_+\|CBS-domain-containing-protein	gnl\|CDD\|341408	cd17772, CBS_pair_DHH_polyA_Pol_assoc, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the DHH and nucleotidyltransferase (NT) domains. This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream nucleotidyltransferase (NT) domain of family X DNA polymerases. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.84254e-51
NC_008554.1\|WP_011697549.1\|821140_822802_+\|pyruvate-carboxylase	gnl\|CDD\|163675	cd07937, DRE_TIM_PC_TC_5S, Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain. This family includes the carboxyltransferase domains of pyruvate carboxylase (PC) and the transcarboxylase (TC) 5S subunit. Transcarboxylase 5S is a cobalt-dependent metalloenzyme subunit of the biotin-dependent transcarboxylase multienzyme complex. Transcarboxylase 5S transfers carbon dioxide from the 1.3S biotin to pyruvate in the second of two carboxylation reactions catalyzed by TC. The first reaction involves the transfer of carbon dioxide from methylmalonyl-CoA to the 1.3S biotin, and is catalyzed by the 12S subunit. These two steps allow a carboxylate group to be transferred from oxaloacetate to propionyl-CoA to yield pyruvate and methylmalonyl-CoA. The catalytic domain of transcarboxylase 5S has a canonical TIM-barrel fold with a large C-terminal extension that forms a funnel leading to the active site. Transcarboxylase 5S forms a homodimer and there are six dimers per complex. In addition to the catalytic domain, transcarboxylase 5S has several other domains including a carbamoyl-phosphate synthase domain, a biotin carboxylase domain, a carboxyltransferase domain, and an ATP-grasp domain. Pyruvate carboxylase, like TC, is a biotin-dependent enzyme that catalyzes the carboxylation of pyruvate to produce oxaloacetate. In mammals, PC has critical roles in gluconeogenesis, lipogenesis, glyceroneogenesis, and insulin secretion. Inherited PC deficiencies are linked to serious diseases in humans such as lactic acidemia, hypoglycemia, psychomotor retardation, and death. PC is a single-chain enzyme and is active only in its homotetrameric form. PC has three domains, an N-terminal biotin carboxylase domain, a carboxyltransferase domain (this alignment model), and a C-terminal biotin-carboxyl carrier protein domain. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	4.60526e-105
NC_008554.1\|WP_011697533.1\|795468_796212_+\|creatininase-family-protein	gnl\|CDD\|376872	pfam02633, Creatininase, Creatinine amidohydrolase. Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.	1.08424e-64
NC_008554.1\|WP_011697532.1\|794076_795390_+\|adenylosuccinate-lyase	gnl\|CDD\|181000	PRK07492, PRK07492, adenylosuccinate lyase; Provisional.	0
NC_008554.1\|WP_011697548.1\|819577_821011_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	0
NC_008554.1\|WP_011697539.1\|801623_802547_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.48178e-98
NC_008554.1\|WP_049766272.1\|798502_800599_+\|hypothetical-protein	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	9.51078e-95
NC_008554.1\|WP_011697545.1\|812575_815308_-\|glucosidase	gnl\|CDD\|367389	pfam03200, Glyco_hydro_63, Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.	7.00483e-13
NC_008554.1\|WP_011697531.1\|792814_793795_-\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	2.56458e-106
NC_008554.1\|WP_011697552.1\|826584_827061_-\|dCMP-deaminase-family-protein	gnl\|CDD\|238613	cd01286, deoxycytidylate_deaminase, Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the enzyme is allosterically regulated by the ratio of dCTP to dTTP not only in eukaryotic cells but also in T-even phage-infected Escherichia coli, with dCTP acting as an activator and dTTP as an inhibitor.	4.64526e-41
NC_008554.1\|WP_011697542.1\|807225_810300_-\|hypothetical-protein	gnl\|CDD\|236140	PRK08026, PRK08026, FliC/FljB family flagellin.	0.00189656
NC_008554.1\|WP_167321310.1\|816525_818622_+\|beta-lactamase-family-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.22824e-51
NC_008554.1\|WP_011697550.1\|822985_823870_+\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|274043	TIGR02225, Tyrosine_recombinase_XerD, tyrosine recombinase XerD. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	1.5978e-136
NC_008554.1\|WP_011697538.1\|800838_801627_-\|ABC-transporter-permease	gnl\|CDD\|130358	TIGR01291, Nodulation_protein_J, ABC-2 type transporter, NodJ family. Nearly all members of this subfamily are NodJ which, together with NodI (TIGR01288), acts to export a variety of modified carbohydrate molecules as signals to plant hosts to establish root nodules. The seed alignment includes a highly divergent member from Azorhizobium caulinodans that is, nonetheless, associated with nodulation. This model is designated as subfamily in part because not all sequences derived from the last common ancestral sequence of Rhizobium sp. and Azorhizobium caulinodans NodJ are necessarily nodulation proteins. [Cellular processes, Other, Transport and binding proteins, Other].	4.69886e-33
NC_008554.1\|WP_083764180.1\|803438_804551_-\|hypothetical-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	3.62145e-69
NC_008554.1\|WP_083763930.1\|811509_812217_+\|DUF1566-domain-containing-protein	gnl\|CDD\|377878	pfam07603, DUF1566, Protein of unknown function (DUF1566). These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	3.35432e-25

>NC_008554.1|WP_083764180.1|803438_804551_-|hypothetical-protein
MKARIGIPDRVTANCAQVPFGKCLCGQTAVDGTFRYFECVKGTNGSPHETARPHGHYCVPILFSDQTLGVMNLTLKAGHPHDRREEEFLLAVANVIAGILQRKQVEKELQLHTQRLEQSNRNLQDFAFVASHDLQEPLRKIQTFGERLRSKYADVLSDTAINYLERMQNAAARMQRLIDALLTFSRVTATSGRHEMTDLRDVIGSVLSDLELCIEQAGGRVEVGFLPVVMADADQMCQLFQNLIGNALKFQAEGSPRIGIRSHWFADGPSDEPADSPGWYRIFVEDNGIGFDEADLERIFAPFQRLHGREAFEGTGMGLAICKKIVESHGGEITARSTPGNGATFIVTLPAGRTAIAGCVQDGCIGPEGI
>NC_008554.1|WP_011697539.1|801623_802547_-|ABC-transporter-ATP-binding-protein
MTNAHAPVIEARNITKRFGDFLAVDAISFDLLPGECLGLLGPNGAGKTSTIRMVYGFSPLTAGTLKIFGVDVSFGWRAVRFGIGVCQQDNNLDPDLTVLQNLEVFAGYFDIPRGAAREKADQLLRFMALDHRRNDMVSSLSGGMMRRMVLARALINDPQLLILDEPTTGLDPQSRHQVWEKLEKLRAQGLSILLTTHNMDEAARLCDRLIIMDHGKILVTGSPLDLVREYAGHHVLEILEPADELRAFVRARELMHDNLDHRLIIYGGENDRLFESIGMDYCGENCIRRMATLEDVFLRLTGRELRE
>NC_008554.1|WP_011697538.1|800838_801627_-|ABC-transporter-permease
MRIGRFDVSRRFIRVWHRNLIVYRKIWLVNFLTPLLEPLLYLAAFGIGLSALIGSVRVEGMELSYVVFITPSLLAITMMYNAFFENTYTSFVRMYYQKTFDAMLATPLSLDEVITGEIMWGATKSLIATVIMLGVVSAFGLVRYPEGLLVIPLSFLGGIAFGAIGMVFTGVIPSIDMFNLPIFLFISPMFLFSGTFFPMEGLPGWAQKLALLFPLTHLVQATRWLCLGVFRVEILWGLAYLVACCLVFFPLALIVMKRRLIH
>NC_008554.1|WP_167321309.1|800642_800795_-|hypothetical-protein
MTGWKSAAVDVRNAGAECFDREMMEDRNVVSGRDPAALPAYLEVSLRKLN
>NC_008554.1|WP_049766272.1|798502_800599_+|hypothetical-protein
MKMESGKRNDKLPELLAPAGHMEGFFAAVDNGADSIYLGLKQLSARASAVNFSLDELARLVPYAHARRVSVIVALNSLVTASELSGIPDVLQSLSDLQVDALIVQDPGVIHLARRLFPSLRLHASTLTTIHNSAGVRQMQRMGVSRVVLARELTLDEIARIRASTGAELEVFVHGALCFSYSGMCLTSSFRGGHSGLRGRCVQPCRLQFRQGRKTGYFLSCNDFSALPFVPELKKLGLAALKIEGRMKPADYVSRVVKAYRLVLDADEAHTSEAVREGMQWIADAPSRRLVSGFLEKNFNETVLTPHRSGSSGLWIGTVKKISQDGAHVSLRRGLKAGDRLRPESKEGKEEPIFRVTGIAALAGTRLAAAEPGDVVVVSGRGGLKAGDRLFRIASESAGAHTTVPNRLKNVKPLTYRKTFSDPAGRAGALGERPEAGGVERQEERLTIKTGTLHHMAEAFKSNPWRVLLTATRTNLERMARQRLPKAQKSRFVWSLPPLISEKSDLEYYARAVNWFVDKGFLLWELNNWGHFDLFAERQGPGFIAGPRFNLRNGAALAAMAEEGCRWSVLSPEITFKELQLLGRMPLPSQPIVSVYSWPPLFTSRLTPKLEEGKPFSTLRGDVYMMERKSDGTRVYADHPVCWFDRLSRLREAGHRHFLIDISEAPDEKALEFHKLILGFRRSRFEGTCHPFNFDREP
>NC_008554.1|WP_011697535.1|797263_797998_-|hypothetical-protein
MRRVSLLLSVVIVLAALCVPVRGATIQGSVLEAKAPHNPLSRDGRVTLYKKSGTEWVYASGASVDETDTTFAFSGLAAGAYSLFVTGDDYVSEYYNNTTLEGERTEIPLAADDTYDAGDIYLRDLPIRLDNPALSSHSVPASGGTVSATVDVVNDTTAEKTVLVRAVLTAMRTAFNATYIRTMHQCGSKTVTVPAHTTVSTTVSIVIPGSASPDVDYNVQLHLGLDKWRPLSDSLYAGYIAKLR
>NC_008554.1|WP_011697534.1|796445_797180_-|hypothetical-protein
MKKYSLFLSAIIVLAAFSFPTQAATIRGRVLEQAPPHNGLATYGSVTLYKKSGTSWVYTSTAHITTTNVSFLFKGLAAGTYSLRIEGYNYKTEYYNNTTVYENRTEITLAADTIRNVGDIYLNPLPIRLANASLSTHNVPAAGGRVIATFDVVNDTAADKELLVMIMLEAKRTIQNATIVSGELQGASKSVTVPAHSTVTATKAIDIPETVPAHTRFDVNLHLTQDKWWPQANPEFLGIIYKSP
>NC_008554.1|WP_011697533.1|795468_796212_+|creatininase-family-protein
MPLIENVTMSAFAEGRKTCRTVILPCGAVEEHGTHLPLGTDALHAVALAGEVARVAGVWVAPPIYYGLCRSGSRHPGTIGIRGSTLQCLVEDILRGFHQQGLLNVLVLSGHAGWTHMAALADACERVLFEFDDLRIAVLSVLDIGAAVWTDLIETPGDSHAGEVETSLMLHLHPECVTGRAPEEYPTFPRHILVRNKQAFWPGGVWGNPAAGNAEKGKLFMERSVKALVEIIEKLENWSEPPESDPA
>NC_008554.1|WP_011697532.1|794076_795390_+|adenylosuccinate-lyase
MIPRYTRPEMGNIWTLENKYRKWLDVEIAVCEVLSESGRIPAEDLRRIKEKAAFDVDRIQEIERETQHDVIAFLTNVAEHVGPSSRFIHEGLTSSDVLDTAMALLLKEASDLLLQDLDRLLEVLGRRAFEFKDTVMIGRSHGIHAEPITFGLKFALWHAEMQRNRKRMADARETIRAGKISGAVGTYANIDPAVEEQVCARLGLVAEPVGNQIVQRDRYAEFFTTLALVGCSIEKIAVEVRHLQRTEVREAEEYFAEGQKGSSAMPHKRNPVASENLTGLSRVLRGNALAAMENVALWHERDISHSSVERIIGPDSTILLDYMLARLTRLLDKLVVYPANMLRNLDLTGSLYFSQQAMLALTRKGISREEAYRIVQRNAMKVWHERGQLPDALKADPDVMKHLSAGEVDAIFDMGYHLKHVDTIFQKVFGRGSPHPV
>NC_008554.1|WP_011697531.1|792814_793795_-|deoxyribonuclease-IV
MPLLGAHMSIAGGLHNAFQRLLQVRGEALQVFLKNQRQWHPPPLSAHAVRLFQEERDNFAHVPVAAHDSYLINLAAPDPDIAEKSVGAFASELDACAQLGIEFLILHPGFHRGAGISTGIARFAKNLDRACALAKAHSVTVLIETTAGQGSGIGSKFEEIADMLMKSKAGRPLGVCFDTCHAFAAGYDLRDERSYERTFDRFEKTIGLRLLRWFHLNDSKAGFGSRVDRHEHIGRGRIGLQGFRLLVNDPRFESHPMVLETPKGKDLRNDRKNLATLRSLLRSVDDSESEPFEEDREADPENGGERRPTPRDPAGSLKRGKPSGHT
>NC_008554.1|WP_011697542.1|807225_810300_-|hypothetical-protein
MSTRWVKSVLAICLILGMLFSASNAPAEWKWEFPTKSTGDLRGVWGFSASDIVGVGTYGTISRYDGVSWTPMFSGTHQNLSGIWGVSSADLYAVGDSGTILHYDGSAWSPVVGGISQHLYCIWGTSADDIFAGGANGTILHYDGLSWSQMTVPVTVSLYGIWGTSAQDLFAVGAGGTILHYDGFSWGIMTSGVSSELRSLWGASSADVFAAGLSGTILHYDGTEWEPMDSGTSQNLLDIMGTSVADIFAAGSMGTILHFDGSGWTSMASGTTRDLYGLWEASPTNVIAVGPNETVRRFDGTTWSNGATWTSIGSGTIQAVWGTSTSNVFAVGSIGLILHFDGSQWGNMNGAGLLGTPFLEGIWGASPSDVYAIGRSGALFKFDGSSWTQQMFPQYYSRDVYGIWGTSSSDIFAVGNGIRHYDGSSWSYTSPTPYLLYSVWGLSSSDVYAVGQYGTVMHYDGSSWTSMNAGLAGSFEPVGVWGTSPDNVFVASGGALYRYDGFGWNTVSYGSPGINPACIVGTPGSELFAGGDFGTILQYTGSSWDRSLVIGGYHNNIVGLYVVPGPRLYALTDKKGLLYNDSFYKITAAAGPNGTISPEGQIDTLEGGARTFSITADSGWHVEDVLVDGTSAGATTSYTFTNMTANHTISAAFAADTYTITASAGANGSIAPQGAVSVNHGSDQTFTITPATGYHVADVLVDGTSAGATTSYTFTNVTANHTISATFAVNTYIITASAGANGSIAPQGAVSVNHGSDQTFTITPATGYHVADVLVDGTLVGATTSYTFTNVTANHTISAAFAADTYTITASAGANGSIAPQGAVSVNHGSDQTFTITPAAGYHVADVLVDGTSAGATTSYTFTNVTANHTISATFAVNTYIITASAGANGSIAPQGAVSVNHGSDQTFTITPATGYHVADVLVDGTSVGATTSYTFANVTANHTISATFAVNTYIITASAGTGGTISPSGQVSVQHGDSRLFTITPKKGRRVAKVLVDGVSVGAVTQYTFTNVTSAHTIRATFK
>NC_008554.1|WP_083763930.1|811509_812217_+|DUF1566-domain-containing-protein
MRAMITVTLCLAGMLGFWGAGIAGSPDQSQIDVNDEDAFSCTDSAVSAIEAAAAPPAAVPKTGQRITYGPRDDGQLRKGVAWPIPRFTDKGNGTVRDNLTGLIWLKDVNCKKFYAGDTGTSNSRSWNSALVSANRLKSGYCGLSDGSVAGNWRLPNVRELESLTAYRFWDPALSNRAGTGHWSEGDPFLGVTWARTPWSSTTCAANSNTAWIYDFSFGYPAGASKTGSWGVWPVR
>NC_008554.1|WP_011697545.1|812575_815308_-|glucosidase
MTAESIRLEESRAGKADWKKWGPYLSERQWGTVREDYSENGDAWNYFTHDQARSRTYRWGEDGIAGLSDNKQRFCFALALWNGRDPILKERLFGLTNSEGNHGEDVKEYYFYLDSTPTHSYMKFLYKYPQAAFPYEDLVETNGRRTRDEMEYELLDTGVFDGDRYFDVFVEYAKKGTEDILVQITAVNRGPEEAQLHLLPTLWFRNDWASWISRPSEKPRLRQIDGSPGVMAAVGAHPLGGEYTLYCQGDVPLLFTENETNNERLFPDYPNAGPYVKDGINNCVVLGQQGAVNPEKAGTKLAAHYRLTLGPGQSARVRLRLVGGPPAGKGRKTKASASPFGPDFDETMTARIREADEFYRSVTPPSVSPDAANVMRQAIAGMMWSKQFYFFDGDQWLDEHRANPLHTGSREFRNREWFHMMNEDIISMPDKWEYPWYAAWDLAFHTLPIAIADPDFAKEQMELMLRGVYLHPSGQIPAYEWNFSDVNPPVHAWATLFLHRTEQALRGTVDLDFLKTAFNKLLLNFTWWVNRKDRFGKNVFDGGFLGLDNIGVFDRSAPLPTGGHLEQADGTAWMALFTQNMAELAVELATHDRAYEDMVVKFIEHFYYIAGAMNRPGQEGMWDEEDGFYYDILRLPDGSAQRLKVRSMVGLLPLCATTVVDKWQRERIPRAMGQLHERLRRMPELMEPIHPTGPGHFGVAERGIIALVNPERLQRILTRMLDEDEFLSPYGIRSLSKFHDRHPYIFHVHGQEHRVDYLPAESNTGMFGGNSNWRGPIWMPVNALIIRALLSFYLYYGDNFKIECPTGSGKMMNLFEVSKEIADRLTRIFTRDESGRRPVYGGTQKFQSDPLWRDHIHFYEYFHGDNGAGLGASHQTGWTGLVAKFIQLYGLIEPQKALEAGKEAAFRKGS
>NC_008554.1|WP_167321310.1|816525_818622_+|beta-lactamase-family-protein
MASPKITGTDRHLHLRPRRSCDNGDLPLAYAATIAASGAEIVKELAGSESKTTAVSVALVDHERLLWAEAFGSIDRAHGAAPTTETLFCIASCSKVIAAVAAMILVDRGMVELDAPLVRYVTDFRMADDEPWRDITVRMLLNHSSGLPGIHFPNVLTVVPFHGYAAQVRDMLATERLKHAPGEMAVYGNDGFMLVECLVTAVTGQPYTEFVEQEILKPLGMNHSRFALEPFAPGSFAPGLDEAGRPEPQEYTNIYSSGLFSTPSDLGNLAMMFLNGGRRGGRRILSAAAVAEMGRDQTVNLAFNPVTDHHVHFGLGWDGILQGGLAAAGVTGWHKAGDADHYHSYFIVAPDERLAVVVMVTNSMGIGSIATPLAERVLLHALAERGRIARLPVPPEPATLPAIPAGDGEPAAFTGIYAGSYGLYRLDVGADRTLTLSSFVNDRWHPAPEGLRLRQDGRFVADSCPERAYRGFVAAGRRYLAVRAPFGMGHYDMELPVGHELLPGQPLSARWQARVGRRWLTANEPCSAFLALGRQPPLICLGEVQGLEGYLAVSLRSAGLDLAQVVDPRDSDHVARMCLKIPIDNGWGLSDLVIEAREGEEWILWCGTRYRPLETVPAPESGRGTVTIGPEGLGEWFRCPAASALTLAGACSWYLYNAEFDLKDWGMGEKTIVGSVDDGSYLLLYGAPGTTVTLTLQP
>NC_008554.1|WP_011697547.1|819102_819366_+|hypothetical-protein
MKIKYCKKYEKYVSQQHCEFFNNGLDCEFYNHAYWNSIKDLSEDENRPKWEVNAVIKPYHCNLLDREYLNERNRRRRLYRKSSGIQI
>NC_008554.1|WP_011697548.1|819577_821011_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MFKKLLVANRGEIAIRIIRSAQELGIKTVAVYEETDKTAMHIMRADEAVCLGSGPRKDYLNIDRIVQAALSTGAEAIHPGYGFLAENPMFSKKCTDAGLVFVGPPPQVIIDMGNKVVARRIMKNAGIPVIPGTDILEEGELGEQDAVDFAEEYGFPIMVKAVAGGGGRGIRVATNVGELIKGLKMARSEARMAFGNDDIYLEKGLGNPRHVEVQIVADRFGDVIHLGTRNCSIQRRHQKMIEIAPASLPADLSENVCRTAVKAAKACNYVNAGTVEFLLDEADNYYFLEVNTRIQVEHTITEMITGIDIVRKQIRIAAGEPISITQKDVTFRGVAIELRINAEDPKNNFMASPGVIQIYQSPGGHGTRLDGAVYQGYEIPRYYDSMLVKLTVYGFTWREAVDRLDRTLKSFAIAGVKTTIPYYKQIVKDPDFIEQRFDTSYIETHPHLLDYQDEVPELEKLASLVAEINARGYNPYA
>NC_008554.1|WP_011697549.1|821140_822802_+|pyruvate-carboxylase
MAENGRPIIPGMSSREILECLRKTPGYFMTNNERDVSQSDFKARIMPATTLRVAPYRDETGYFAFEITGGATVHVDLMRKQINPVEKLRLVRKAMPNTLLQAVCRGRNLFGYRPYPDNVVRMTVRLFSEYIDVWRLYDFLNHIPNLMVAAEEVKKAGKLLMPCICFSTGPEHTDAFYAGKVAEILSAMGEDIILCIKNHSSLGSALRIGELVKAIRREFPNLLLAYHGHNTDGNDLARMVAAVQEGVKIVEVSDHGFGGIYSQAPALSFIQTLHDYGCSAPGLNIQPLLETSDILRRERRLYDKYEGHYHGFDPTVKQHKLPGGAASIAFEQAEKAGLMDRTQEIFSELSEVNRELGNIWMVTPGSQILWATAMNNILHGRYEKPSDDLKRLLLGRYGPFPFYDPHEWIYQKVLESGRTDGKRWDEILSTEAGVQHLADEDLEERRRQLALKLKRPVTEEELCLALQFPRDAVEYFLFEERFGKTWMLPPEVWFNRGGFADGTRITFADYDGKTHHIDIVSTRKSAGMVHTALLLDYHFQTYTTAVSSKEPAV
>NC_008554.1|WP_011697550.1|822985_823870_+|site-specific-tyrosine-recombinase-XerD
MDRWLDLFLNHITVEKGLSPNTVAGYGGDLQEMLGYFGKHGVSSWEAVSREDIVSYLESVSGRLSHRSKARRLAALRAFFKYLERTGKMSGSPAALVRFPKFNPGLPKTLTGREVDALLAAPAAGTPLGQRDRAMLELLYATGLRVSELADLQLDQVHLEAGYLVARGKGDKERPVPMGEPAGEALQIYLRDGRRRLLKDGRSREVFLNRRAVKLTRQGIWKIIKQYALKSGIRQNLTPHVLRHSFATHLLENGADLRSLQAMLGHADISTTQIYTHVAKKRLKEVHLKFHPRP
>NC_008554.1|WP_011697551.1|823882_826549_+|CBS-domain-containing-protein
MEVITTHINADFDAMASMIAAKKLYPDAVLVFPGSQEKTLREYFINSTVYIYGFKRLRDLDLDRVSRLILVDTRQISRIGRFVEILDRPGMDIHVYDHHPDAEDDIQGVFNLIKPVGATVTILTQLIRERGLEVTPEEATIMSLGLFEDTGSFTFNNTTPEDFEAAAFLLRSGADLNAVSDMVTQELTAEQVGLLNELITSAKTYGIAGIDVCIATVSVEKYVGDFAVLVHKLKDIENLDVVFALARMDDRVYLVGRSRIPEINVSTVAAYFGGGGHATAASASIKDLTLFQVENKLLEFLRSYIHPYPTAESMMTSPVIFTEPEVTVAEAGQSMIRYNINSMPVMEDGRIVGLTTRQVLEKAIFHGLEKRAVREFMTTDFSTVGPNATLLEIESYLVERHQRIVPVMEDNRVIGVITRRDLLKFLVEDQTTNARSLYGDTNLAAWSKRKNVVAVIMEQLPREIVQTLKDFGKLAKDLGMKAYAVGGFVRDLLLRRSNLDIDIVVEGDGIEFARTYAREHGIRCRFHKKFNTAVLIFPDDRRVDVASARFEYYQYPAALPIVEFSSLKMDLYRRDFTINTLALALNPGEFGQLIDFFGGQRDLKDKTIRVLHNLSLVEDPTRILRAIRFEQRFGFRIGKQTVALIRNAVRMGLLQKLGGRRLLHEIQLIMVEDDPLPPLRRMNEFAVWPVLSANILFDQKLEDLFVRLREVVSWHRLSFLDEPLERWWVYMLGLFSGLAAADVEDACGRLQFTAGQRERIAWAYRTVSGLLWGFFPAAEHKPSAIFRALQPFKPEELVFMMAKAQDETPRRAVSHYFHRYRHVSTELKGRDLKEMGVPPGPIYRVILDELLDARLNGEVKDRQEELAYLRERHAELFGGEGEVPDPAS
>NC_008554.1|WP_011697552.1|826584_827061_-|dCMP-deaminase-family-protein
MNRPTKSEYYTEIALSVAQRSTCLRRRFGAVIVKSDQIISTGYNGAPRKTANCIDLGYCARKQLSIPAGQNYELCRAVHAEMNAVIHASRLDMVGADLYLAGLDVETGNQVIHPEPCLLCRRVIINAGIQRVVVPAESEGFHYIDVDDWILQDRVSFK

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Crispr_ID: NC_008554_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_6

940424-940523

Orphan

Consensus_repeat	Method
TTTCCTGGCCGAAGCGCATTCGGACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_6

>merge|NC_008554|6|940424-940523|CRISPRCasFinder
TTTCCTGGCCGAAGCGCATTCGGACGCTCGCAGGGCCGAAGCCGCCGCCGACAAGGGCGAATCATGGAATTCCCTTTCCTGGCCGGAGCGCATTCGGACG

>NC_008554|6|6|940424-940523|CRISPRCasFinder
TTTCCTGGCCGAAGCGCATTCGGACG	CTCGCAGGGCCGAAGCCGCCGCCGACAAGGGCGAATCATGGAATTCCC
TTTCCTGGCCGGAGCGCATTCGGACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011697641.1\|945454_946420_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176197
NC_008554.1\|WP_011697642.1\|946553_947039_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NC_008554.1\|WP_011697638.1\|940582_941716_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NC_008554.1\|WP_011697632.1\|930910_931693_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_008554.1\|WP_150109611.1\|949037_949304_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|376329
NC_008554.1\|WP_011697645.1\|950206_950797_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|179661
NC_008554.1\|WP_011697636.1\|937653_938340_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_008554.1\|WP_167321313.1\|951106_952765_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379441
NC_008554.1\|WP_011697633.1\|931937_933278_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_008554.1\|WP_011697631.1\|930374_930815_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697643.1\|947056_948901_-\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NC_008554.1\|WP_011697634.1\|933380_936500_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_008554.1\|WP_011697639.1\|942047_943388_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NC_008554.1\|WP_049766282.1\|953332_954676_+\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NC_008554.1\|WP_041441658.1\|938604_940380_+\|type-II/IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|225363
NC_008554.1\|WP_011697635.1\|936499_937657_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_008554.1\|WP_150109423.1\|929367_929841_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697629.1\|927500_929333_+\|outer-membrane-protein-assembly-factor-BamA	unknown	unknown	gnl\|CDD\|274514
NC_008554.1\|WP_041439790.1\|943965_945033_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NC_008554.1\|WP_011697628.1\|926501_927296_+\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|188247

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011697641.1\|945454_946420_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176197	cd08235, iditol_2_DH_like, L-iditol 2-dehydrogenase. Putative L-iditol 2-dehydrogenase based on annotation of some members in this subgroup. L-iditol 2-dehydrogenase catalyzes the NAD+-dependent conversion of L-iditol to L-sorbose in fructose and mannose metabolism. This enzyme is related to sorbitol dehydrogenase, alcohol dehydrogenase, and other medium chain dehydrogenase/reductases. The zinc-dependent alcohol dehydrogenase (ADH-Zn)-like family of proteins is a diverse group of proteins related to the first identified member, class I mammalian ADH. This group is also called the medium chain dehydrogenases/reductase family (MDR) to highlight its broad range of activities and to distinguish from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal GroES-like catalytic domain. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	3.13064e-75
NC_008554.1\|WP_011697642.1\|946553_947039_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	9.26935e-86
NC_008554.1\|WP_011697638.1\|940582_941716_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.34707e-62
NC_008554.1\|WP_011697632.1\|930910_931693_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	6.37122e-35
NC_008554.1\|WP_011697645.1\|950206_950797_+\|adenylyl-sulfate-kinase	gnl\|CDD\|179661	PRK03846, PRK03846, adenylylsulfate kinase; Provisional.	5.71291e-110
NC_008554.1\|WP_011697636.1\|937653_938340_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.83612e-18
NC_008554.1\|WP_167321313.1\|951106_952765_+\|hypothetical-protein	gnl\|CDD\|379441	pfam14052, Caps_assemb_Wzi, Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.	8.91549e-123
NC_008554.1\|WP_011697633.1\|931937_933278_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	7.29742e-43
NC_008554.1\|WP_041441658.1\|938604_940380_+\|type-II/IV-secretion-system-protein	gnl\|CDD\|225363	COG2804, PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion].	0
NC_008554.1\|WP_011697643.1\|947056_948901_-\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NC_008554.1\|WP_011697634.1\|933380_936500_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NC_008554.1\|WP_049766282.1\|953332_954676_+\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.08011e-46
NC_008554.1\|WP_011697628.1\|926501_927296_+\|tol-pal-system-protein-YbgF	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	3.32676e-36
NC_008554.1\|WP_011697635.1\|936499_937657_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	9.95404e-65
NC_008554.1\|WP_011697639.1\|942047_943388_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	2.13143e-06
NC_008554.1\|WP_011697629.1\|927500_929333_+\|outer-membrane-protein-assembly-factor-BamA	gnl\|CDD\|274514	TIGR03303, OM_YaeT, outer membrane protein assembly complex, YaeT protein. Members of this protein family are the YaeT protein of the YaeT/YfiO complex for assembling proteins into the outer membrane of Gram-negative bacteria. This protein is similar in sequence and function to a non-essential paralog, YtfM, that is also in the Omp85 family. Members of this family typically have five tandem copies of the surface antigen variable number repeat (pfam07244), followed by an outer membrane beta-barrel domain (pfam01103), while the YtfM family typically has a single pfam07244 repeat. [Protein fate, Protein and peptide secretion and trafficking].	8.11369e-89
NC_008554.1\|WP_041439790.1\|943965_945033_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	1.90864e-83
NC_008554.1\|WP_150109611.1\|949037_949304_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|376329	pfam00381, PTS-HPr, PTS HPr component phosphorylation site.	4.61654e-30

>NC_008554.1|WP_041441658.1|938604_940380_+|type-II/IV-secretion-system-protein
MKNHGPHRLDLGELLEDLVADGMVAQADAARIPRLAPTKDKAEVHPLKIIADRRLNRASPPHELLTLETLTAWLAKTADLPYQRIDPLKIDVTSVTGIMSYAYASRFKILPIEVTDEQVVIATSEPFVTEWEEELHRILHRKIVKVVANPVEVSRYLVEFYALNESVKRAFGMADQTRLAGTMNLEQLLELGRAGKLDANDRYVVNIVDWLLQYAYDQRASDIHLEPRRDNSDIRFRIDGVLHLVYQLPTVVMSAVTSRIKVLGRMDLAEKRRPQDGRLKTKSPAGGEIELRLSTMPTVFGEKLVMRIFDPEVTIRSFEDLGLSKSEISAWKGMVSRPNGIILVTGPTGSGKTTTLYSTLKHLARPEVNVCTLEEPIEMVEPRFNQMQVHHGIGLDFANGLRTLLRQDPDIIMVGEIRDLETAEMAVQAALTGHLVFSTLHTNDAVSAIIRLMDIGVPHYLIRATVLGVVAQRLVRTLCASCKQEGAVDEDLWQALISPWKMTRSNAFYQPAGCLECRETGYRGRMGIYEIFTMSPALLQLIKPDADISQIRAQAIKEGMYPLAIAGAKKVCAGLTTVEEVLRVAGAGSEI
>NC_008554.1|WP_011697636.1|937653_938340_-|TetR/AcrR-family-transcriptional-regulator
MNPDARNIPGERFRAKALEVISPGAPPQEQKTKMRIFLAAAQLFAQRGYNGTAVREIVELAGVTKPTLYYYFKNKEDVYIKLMDSAFAVFSQVLEESARRPGSMRQRLTALFTSIFQLFEEYVDLVRLVNSTIYGPRGATPDYDLDPGDTQIIGVFTDILRAGEAEGELAPQDRHMILVLLLGLFRSMQLPLLVEPAHAVFSQMDIPRLIDLVFDGARHSIHGEAART
>NC_008554.1|WP_011697635.1|936499_937657_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MKKPVFIIAGAVVLLAFTVLIVATKKGRQVQANHAHVVAVELVNPARSTLKSVVEVFGSLSPKTATEVKSEQPGRILKVQVKEWDRVNPDDVLLELDPTDFKLVVNKDEAGLKMARAQLLQAKVDLDRARRELNRAQKLKDGGLVTGQELDERRTAMESAAARVALAEAQVGQSESQLAESRHNLAKTIVRAPIQGTVYQRKVDVGDWVDKGTPLFSIVDNRVLDFTANVPAVDLARVREGQLLTFLVDGLPNRVFEGKIKRINPMVNNSDRSGRVQAEVQNGDEVLKGGVYARGQVLVAEYSDVLTLPKACLIGWDMDKETARVFLVDDAATARSRSVTTGLVSDDLVEVRSGVNVSDRVVVRGGFNLREGDKVRETTPGEARS
>NC_008554.1|WP_011697634.1|933380_936500_-|efflux-RND-transporter-permease-subunit
MFLSELSIRRPVFATVMMLALVILGIFSYRHLNIDMYPDVEIPVLTITTVYEGAPPESVEREITRRIEEAVNPIQGVKHISSTSQEGISSIVIEFTLETRINDAAQEARAKVSAIRGDLPKESDESVIQKLDFSAAPVVSLAVRSAVLDAKALTTLVDKRVKRRIENVAGVGRVDLVGDSKREVNVWLDPTRLEALGLGVNEVISGLGHENVDTPLGRLNREGVEMPVRVSGKPAEVSGYPDMVVAWRDGRPIRLKEIARVRDGVEEPRSLALVDGVPSVALDVLKQSGANTVAVADGVKRIVGVLAPELPQGVEIQVVRDSSKFIRDSVEDVETTILLGGLLTILIVFCFLNSWRSTVITGLTLPISVISSFIVMNALGFTLNVLTLMGLSLAIGLLIDDAIVVRENIVRHLQQGKDHVRASLEGTAEIGLAVMATTFTIVAVFVPVAFMRGIVGKFFYQFGITVTFAVLLSLFVSFTLDPMLSSRWVDPDVEGGAGTGRNFIYRALVRFNELFERVASFYRLVISWSLDHRKTVLGIGGAAFFSAVSLSPLLGSSFFPVYDHAEFQINFTCSPDAGLDESRGRTYAILNALRGVPGIELTYATVGAGETGTVREGAVYVKLKDRRDREYDQAELESMVRERLARIAGIIPGIVYADSMHGGAPINMNLKGDDIGTLKSLSEGLKKLMTQVPGVVDVTSSLDEDKTEVRLQVDRAKAVDVGLSTLQVVETLGPLVGGKVAGTYEDPDGDSYDVRLRLPDDYRRNPSQVGRLTLLSVKEDGTRTLVPLGDIAQFNLDISPARIQRLDLRRQVTLSANNAGVPLGDAIDAIRNKVEAVGLPPGYVISWSGEAEDMAETFQYIFEALALAVILIYLILAAQFESFIAPLSIMISLPLSLVGVVVILFFTNDTLNIMSLIGLIMLMGLVTKNAILLVDYSRVLRKTGMDRRTSLIEAGRTRLRPIIMTTLAMIFGMLPLALALGPGAEMRAPMARAVIGGLITSTLLTLILVPVVYTVLDDVMLALGRRFRRKAPEHGAVAG
>NC_008554.1|WP_011697633.1|931937_933278_-|TolC-family-protein
MPHALILLLTLPVFVAFTIQPCSADSETAPREITLKECLERTLAYSRDVLIANEGRNMSRGRYIEERSAALPQFRADAHVARAHNDQYPLQGFPVELTEYAGNVKLTQALFTWGQIGAAIKAAGYDKTSAEHQLREAKQLALREAATSFYDLLLTLELAKVARDNVAQKQRHLDETQRRHQMEVATDYDVLSASVALANAQPALAQAENDIRLAGDRVGYYMGIREDFKVSGSLICRTRRPETLEVVLERARTNRPEVAYYESRVGVFKELLRVAKAGDKPRLDFQTNLGWSSYDTITDQLPGQHWDAGIYLSFPIFDGFLTKGKVIQAKSRLATTDFEMKKLLDNIALEARSAINRVDESIRVIEALEATTTQAERLLHMAELGYKNGVKTKLEVDDAESNLLAARINLVKAQRDYVVAQTRLLWIMGEDLQTALTTSDFLPACR
>NC_008554.1|WP_011697632.1|930910_931693_-|sulfite-exporter-TauE/SafE-family-protein
MSLIAGIIAGIFGGLVGLGGGVIMIPIMVDFLKAGQHEAHGTSLVAIIFAGLAGALTYQLHGSVDWAASVLLAATAMITAQYGARFAGVLPEWKLKKSFGAFLLFVSALMLVKPYLPHFAPDAFSRWSQVLILLSTGTFTGFLSGMMGIGGGTVMVPAMVLLLGFSQQTAQGSSLLAMVPAGAAGAFTHQRLGNVRAALLTGLVPGILVGTYVGGSIANMLPEMQLRLIFAAVIVFTGVRYLRTPTPPSTESPATKQADA
>NC_008554.1|WP_011697631.1|930374_930815_+|hypothetical-protein
MRSFESLIAKNNLSMEMARVESNPIIGNVDAIEGVEHYQCRLYRPGRKLDVYLSIGPGEGTLTLADVLYMLAMDASGCSMMKGYADCVDAQPLVFGTDGNFPEIGAFWQEFRGRCKQAARLKDFLGETSYRELETWGQTYTFHKTP
>NC_008554.1|WP_150109423.1|929367_929841_-|hypothetical-protein
MPENEMAVESKLIPILREGVDLVKMILFRRLRLHLANAYPEQDASYVNRMAGAVINDLFGDSPPAEPFAGFARDHAEAIDREVRRIAVSMSDMLIPLTDALRIQFLCDYQEGVDSTPVLARANELGILLSDREVPLPARFISMVRKLGSSLQLVRKT
>NC_008554.1|WP_011697629.1|927500_929333_+|outer-membrane-protein-assembly-factor-BamA
MRPQFLTRTLCIVVLVAGCVLHAGESRSEPVSPLQVRVIRFEGLHSFSPAELKKVLVTREKKFGWFTKAPLEEKTLAEDIERLEKYLVSHGFYHARVHHEVQRVFRSEVRLLIRVEEGPPMTVSRMNLVVDGASSGPWHREVVSVLPLREGDRFTIPAYEDIEKRVLLHFSDWGFPKVRIDVRARLDKKSNTGVVSVDVTRGPVCFFGAVKIEGNEQVSDEVILREFTFHQGERFSAAKVQETQQRLFNLDLFQLVDFTVEKLDTNETVLPVRVLVKESKPQTIRVGAGYGTEDQFRGQAQWEIRNFLGDGRRLQVNMKASSLVQLAETKFVQPYFLYPRSTLTVEGGGLHEDQESYENRKFYLKPVLNYKWTDTLSTFIGHDLEANRLLDVKLDAPALSAADQEQEEYFVSSFLGGVVWEKVDNTLNPKKGWRVLPNLEVASAELGSNVEFVKFTLEGRGYVPVRDFGVLAAKLKWGGIRPMEGTPDIPIFKRFFAGGTDSVRGYPYQRLGPLDGDGNPIGGMTLVEGSLEWRFPVYKEFDGVLFFDFGNVYSSSFEILWDDLRYSAGCGIRYNTIVGPLRLDFGYALNPPEGDFFSPFQVHFSIGQAF
>NC_008554.1|WP_011697628.1|926501_927296_+|tol-pal-system-protein-YbgF
MRGNFFRFAGILVFLCVVGTCGGCASTQETSTLQQSMTILYDRQEKMERRLEGFDAQSHKGGDLYARIEELQVRVGRLNGRIEELEHKIEQLSRAAASPPATAASPPPDHGSAPPPVAVSPPPPPAPAPPPPVTPPPERENPEKIQYEKATRAYQSGKYEVARKEFQSFLSKYPKSELADNALFTVGECYFSEKRYQDAIEVYQQVLDQYPRGNKVPNALLKQGTAFQQLGDSTAARILYERLVEKYPGTPQAQAAEKKLKQMR
>NC_008554.1|WP_011697638.1|940582_941716_+|metallophosphoesterase
MFFFLLTFVSIYTCMNALFYVKTRILFPDQWLWRGPYIGFLLLMIVSPICTRLLERSGYDGAARVFACSGYFWMGFVFIAFCIFLAVMLVDLAGMGLGLLLPAHIPRLSGKGTTAGLLSIVLVLSVYGVFEARSVRVERVVVHTGKLPPGVDRLKIAQISDVHIGLIVGSGRVRLILDRVREENPDLLVSTGDLVDGNAGKHDGVTEQFQALNPRLGKFAVTGNHEMYAGLEESIATTGRYGFKLLRGEARVVGNTINIVGVDDPVIGGAAPDEAKLLAVGGNGLFTLLLKHRPDPLEQSLGLFDLQLSGHTHLGQIFPFRYITGRAHPLQNGFHQLEKGSALYTSRGSGTWGPPMRLLAPPEVTVIELVRPEAAAQ
>NC_008554.1|WP_011697639.1|942047_943388_-|HEAT-repeat-domain-containing-protein
MSKTTQISIWRNKYILLIISCITIYILSKNVIPKYSNALSSIYFGVSITSFVYFSLTIAIFISIVLIIIELSHLSKYRIVNIFISIFKWSLATLIISPLIVIILNIWIIPTIKIYQDTPKYKKLAYSMILQALKTDPDLEVRKNAVLGLRKIGDLESINTLSEEMTKQPALAGLIGQRISKPKQTEKIDKHRLLGILKQMETDDTLSVIEYKQKILREASQTRRVLRNLKEVFSGSRLTDAERTIVQVSGLSNSISEAINQLNLISKIYSTIELNDDFPKTITHLNSVINAFDKTYGDESAIAQSNSLLSDLGLLVKVCRTSAEQFGQSLQRKPSKLTQYKHIIVMLTRIAPDESLELFRKIVKNDKVPVSIRKAVTLAIGDIGKPEDYQLLTELFDSPHSDIRISAIQSISFMLYRESHPKVNNMSDSEDETEFYLDFENEEEDE
>NC_008554.1|WP_041439790.1|943965_945033_-|anthranilate-phosphoribosyltransferase
MSDESRLREFGRMICSVAAGNHLSRESAMEAYRQVILNEQPELQQGAFLMAHIARGPSIPELSGAWDALDRYDTAKIHTRLTGPVCDIVGTGSDAMKTVNCSTPAALIAAAAGLPVAKKGARLVTGVSGASDIMEIFGIDLGAPLSRAEQCLERYGICYLPGEAFLESGWARLIQSMRFTSAFNIIGPLTRPCEQNNCIVIGAYGPTVCNQLIAVLREIGMPAALAPYGMVEGGDPKRGMDEFSTAGPTRVVELKNGEIETYEVTAEDFGAITGDFAAIASHATARDNARAILRVLEGEYDTPLADFFCVNAAAALYVAGFAKDYRQGFHTAKEALSSGKAREKLRQLTEIQGKS
>NC_008554.1|WP_011697641.1|945454_946420_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKSLVLESPGVLKLTDMQVPEPEPHERLLRVTHCAVCRTDAKMWSQGHRDLRLPRILGHEVCVVPSDSSGRFVVWPGTACGTCEYCRKGFENLCSAMEILGFHRHGGFAEYLAAPADSLVPVPPELPGAIACLAEPLACTLNALDRVGAAPGERLLIYGAGPVGLLMALAARSRGALPFLHEINAEKLARSHDFRGQIGAELHREDRPGDYDVAVNAAPAWETLGAGLRNLAAGGRFCVFSGFPAGDPVPAGLINEIHYRQLVVSGAYGCTRDQMREAVGILCAFREAAQRLIEDTIGLPRVADAFSSILSGMVLKFVVAL
>NC_008554.1|WP_011697642.1|946553_947039_-|SsrA-binding-protein-SmpB
MTKNKPSTAEKTRLICQNKKAYHDYDILEKFEAGIVLLGTEVKSLREGRANLKDSYARVRKGEVFLQGLHISPYTHASYNNHEPERVRKLLLHAHEIKRLTGKTQERGLALIPLKLYFSKGKVKVELALAQGKKLYDKRESIKRKEENRELDRLRKRRRQE
>NC_008554.1|WP_011697643.1|947056_948901_-|phosphoenolpyruvate--protein-phosphotransferase
MNRSSRIIQGIGVSPGIAIGKAFLLERGRVPIPKDKVEGEDAVAEECLRFEKAVSTAERDLEAIRKGIHRDFKEQAHVLEVHQMILRDRLIYSETLRLIREESLNAQWALMRCLAKARDLFDSLGDEYIRSRIVDIEAAGERVLRILAGQERNVLNDIRERVIVVAHDLSPADTAQLQIERTLGLVTEMGGRTSHTSIIARSLNMPAVVAAEQATKWVPTGDIVIVDGTSGKVIVNPTDEQISFYYERQQELDNYLQEINRTAHLPARTMDGHLVKVEANIELLEEVVGAKDFGAEGIGLYRTEFFFMNRADLPDEDTLFREYRDLSELMAPQWVTMRTLDLGAEKLATWYPRLDEPNPALGLRSIRLCLHYREIFKTQLRAILRASAVCRNTRLMFPMVSGLGELIEAKRMLQEVREELQRERIPFDERMPVGVMIEVPSAVAVADMLAPEVDFFSIGTNDLIQYSLGIDRANEHVAYLYEPLHPAVLRFIKHTVDVGRKAGIEVALCGEMAGEPLYVPILLGLKVNTFSMNPQSVPRVKNLICRSYMKECTRFVNKVLRMGTADEINRVLEKVVTRYFPEEFRVFDPSNLVPGGIAPSYRRNRTRTDPNHRK
>NC_008554.1|WP_150109611.1|949037_949304_-|HPr-family-phosphocarrier-protein
MEQEFTVANRLGIHARVAAQIVKVASQFEAEVWVSKCDNHKVNGKSILDLMTLVCPHGSKVRIYASGPDAGQAMNALAALFQTKFGEL
>NC_008554.1|WP_011697645.1|950206_950797_+|adenylyl-sulfate-kinase
MNFYRFESSVSRADRYILNGHRSGLLWFTGLSGSGKSTLAHAVEARLFQIGVRSYVLDGDNIRHGLNKDLGLTPEDRMENVRRIAEVSKLMVDAGLLVFTAFIAPYSESRRFVRELMSKWPFYECYVKCPLEVCEQRDPKGLYKRARAGEILNMTGLSAPYEEPENPELIVETDRNSLDASVDAVIAFLQAQKMID
>NC_008554.1|WP_167321313.1|951106_952765_+|hypothetical-protein
MRKSVSQLMVLCILVCPGWCPSAFSAASPNVPVDHWSYPALERIEAFGLIHSSLHGTRPFSREETARLIKEALTAKESSGKPLPPIIMHLLEKLQREFKPELDVYGTECARSSYLKPIEEAQIRYVYTDGDPRRYTGYPGSVFEADVTEGTPLVYNNEGVVYGKYNNFSVQFASTFGVGDFFAGSIEPIFLVQENEGHNDNVPGTVSADLLKGYGKLSRWNVELEFGRDSMWWGPGRHGELLMTNNATPFDMLKLSNPEPVLLPWYFSYLGPFKYTIFLSRLEDYRVRPLAPGPIDERPVYVGTSSFGGWRVDCKPHPLFELGVSSTFIFGGPGIPSLDFGDVLGLFGLGNVTAANNKINQLGSFDFRLRLPWLRNSVIYGEYAGEDAGGIGGPWYTSLFNDVGYSLGLYVPRLTDDGMTDLRVEWAKNAHIVGPTPGVWYGHNIFIGGYAHDDLMIGHHMFGDAEDLFVRITRYLNKDLLVGLDYDYMKRGITLSPVQESINQWGVDITYDINAHFSVTARYGFEIVDNFDLVEGDTRHNNLVMTMLKVEF
>NC_008554.1|WP_049766282.1|953332_954676_+|oligosaccharide-flippase-family-protein
MLGERIMALLSLKNLDGRMQEVVRGASTAFLIKILAAGVGFASNIVLARCLGAEGAGHYFLVLTVVTVAAVFGRMGLNNTILRFASANVSQGNWESVKGVYAKGIGFAVGASGLTGILMFVSAPVVAERLFNNPELTGLLRWMSLAAIPLAISALYAQLLRAVDNIRDAMMVLSAWVPLFFTVGTVALAPSFGPRGAVWAYILATVLTTLIAMWVWRRETPCLRGIKGHFETGELLASSIPLFFASCWQLIMQWCSNCFLGVWSTSADVGIFAVANRTASLTTLILVAVNSISAPKFAALYSRGDLSGLGRLARGSAKMMTIMSVPIIIPLVFAPGLVMGLFGPQFAGGGTSLALLALGQFVNVATGSVTAVLMMCGYERVANNIMAFSALCCVVANLALIPFWGVLGAAAATAITLIAQNLLGVVMVWRLLGIMTIPGLFSKRAQR

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Crispr_ID: NC_008554_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_7

1060396-1060485

Orphan

Consensus_repeat	Method
CAATGCCCCGCGCACCTGAGGAGGAGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_7

>merge|NC_008554|7|1060396-1060485|CRISPRCasFinder
CAATGCCCCGCGCACCTGAGGAGGAGCCGACCCAAACCGGGTGAATTCCGCCGGACCCATCCAATGCCCCGCGCACCTGAGGAGGAGCCG

>NC_008554|7|7|1060396-1060485|CRISPRCasFinder
CAATGCCCCGCGCACCTGAGGAGGAGCCG	ACCCAAACCGGGTGAATTCCGCCGGACCCATC
CAATGCCCCGCGCACCTGAGGAGGAGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011697735.1\|1071586_1072396_-\|purine-phosphorylase-1	unknown	unknown	gnl\|CDD\|350170
NC_008554.1\|WP_011697724.1\|1057476_1058949_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236901
NC_008554.1\|WP_011697728.1\|1062365_1063403_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
NC_008554.1\|WP_011697732.1\|1068741_1069728_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|163279
NC_008554.1\|WP_011697723.1\|1055967_1057476_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_008554.1\|WP_011697717.1\|1050837_1051185_-\|iron-hydrogenase-small-subunit	unknown	unknown	gnl\|CDD\|376750
NC_008554.1\|WP_011697720.1\|1053479_1053668_+\|CooT-family-nickel-binding-protein	unknown	unknown	gnl\|CDD\|378406
NC_008554.1\|WP_011697730.1\|1066390_1067518_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380570
NC_008554.1\|WP_011697716.1\|1049849_1050338_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	unknown	unknown	gnl\|CDD\|376507
NC_008554.1\|WP_011697718.1\|1051198_1052452_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|274171
NC_008554.1\|WP_011697734.1\|1070746_1071667_+\|carotenoid-biosynthesis-protein	unknown	unknown	gnl\|CDD\|367884
NC_008554.1\|WP_011697727.1\|1061572_1062346_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223488
NC_008554.1\|WP_041441704.1\|1065174_1066047_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223633
NC_008554.1\|WP_011697726.1\|1060878_1061580_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213191
NC_008554.1\|WP_041439828.1\|1055117_1055594_+\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|178927
NC_008554.1\|WP_011697715.1\|1048013_1049732_-\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|224806
NC_008554.1\|WP_011697721.1\|1054013_1055069_+\|phosphoesterase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223691
NC_008554.1\|WP_011697731.1\|1067619_1068351_-\|TraB-family-protein	unknown	unknown	gnl\|CDD\|350608
NC_008554.1\|WP_011697733.1\|1069758_1070754_+\|adenosyl-hopene-transferase-HpnH	unknown	unknown	gnl\|CDD\|274595
NC_008554.1\|WP_041441700.1\|1058987_1060334_-\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011697735.1\|1071586_1072396_-\|purine-phosphorylase-1	gnl\|CDD\|350170	cd17877, NP_MTAN-like, nucleoside phosphorylases similar to 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs), as well as futalosine nucleosidase and adenosylhopane nucleosidase. Bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.32621e-26
NC_008554.1\|WP_011697724.1\|1057476_1058949_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.71557e-69
NC_008554.1\|WP_011697728.1\|1062365_1063403_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.10492e-74
NC_008554.1\|WP_011697732.1\|1068741_1069728_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|163279	TIGR03466, HpnA, hopanoid-associated sugar epimerase. The sequences in this family are members of the pfam01370 superfamily of NAD-dependent epimerases and dehydratases typically acting on nucleotide-sugar substrates. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of hopene, the cyclization product of the polyisoprenoid squalene. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnA was assigned. Hopanoids are known to be components of the plasma membrane and to have polar sugar head groups in Z. mobilis and other species.	4.68056e-173
NC_008554.1\|WP_011697723.1\|1055967_1057476_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_008554.1\|WP_011697717.1\|1050837_1051185_-\|iron-hydrogenase-small-subunit	gnl\|CDD\|376750	pfam02256, Fe_hyd_SSU, Iron hydrogenase small subunit. This family represents the small subunit of the Fe-only hydrogenases EC:1.18.99.1. The subunit is comprised of alternating random coil and alpha helical structures that encompasses the large subunit in a novel protein fold.	8.17695e-19
NC_008554.1\|WP_011697720.1\|1053479_1053668_+\|CooT-family-nickel-binding-protein	gnl\|CDD\|378406	pfam10133, RNA_bind_2, Predicted RNA-binding protein. Members of this family of bacterial proteins are thought to have RNA-binding properties, however, their exact function has not, as yet, been defined.	3.36895e-24
NC_008554.1\|WP_011697730.1\|1066390_1067518_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380570	cd06347, PBP1_ABC_LivK_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	1.99258e-147
NC_008554.1\|WP_011697716.1\|1049849_1050338_-\|NAD(P)H-dependent-oxidoreductase-subunit-E	gnl\|CDD\|376507	pfam01257, 2Fe-2S_thioredx, Thioredoxin-like [2Fe-2S] ferredoxin.	5.52525e-58
NC_008554.1\|WP_011697718.1\|1051198_1052452_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|274171	TIGR02512, Periplasmic_hydrogenase_large_subunit, [FeFe] hydrogenase, group A. This model describes iron-only hydrogenases of anaerobic and microaerophilic bacteria and protozoa. This model is narrower, and covers a longer stretch of sequence, than pfam02906. This family represents a division among families that belong to pfam02906, which also includes proteins such as nuclear prelamin A recognition factor in animals. Note that this family shows some heterogeneity in terms of periplasmic, cytosolic, or hydrogenosome location, NAD or NADP dependence, and overal protein protein length.	6.98374e-170
NC_008554.1\|WP_011697734.1\|1070746_1071667_+\|carotenoid-biosynthesis-protein	gnl\|CDD\|367884	pfam04240, Caroten_synth, Carotenoid biosynthesis protein. The representative member of this family is CruF, a C50 carotenoid 2',3'-hydratase involved in the synthesis of the C50 carotenoid bacterioruberin in the halophilic archaeon Haloarcula japonica.	1.98881e-19
NC_008554.1\|WP_011697727.1\|1061572_1062346_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223488	COG0411, LivG, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.07401e-127
NC_008554.1\|WP_041441704.1\|1065174_1066047_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|223633	COG0559, LivH, Branched-chain amino acid ABC-type transport system, permease components [Amino acid transport and metabolism].	1.18491e-71
NC_008554.1\|WP_011697726.1\|1060878_1061580_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213191	cd03224, ABC_TM1139_LivF_branched, ATP-binding cassette domain of branched-chain amino acid transporter. LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.	1.18844e-118
NC_008554.1\|WP_041439828.1\|1055117_1055594_+\|ribonuclease-HI	gnl\|CDD\|178927	PRK00203, rnhA, ribonuclease H; Reviewed.	2.10849e-92
NC_008554.1\|WP_011697715.1\|1048013_1049732_-\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	0
NC_008554.1\|WP_011697721.1\|1054013_1055069_+\|phosphoesterase-domain-containing-protein	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	5.08893e-38
NC_008554.1\|WP_011697731.1\|1067619_1068351_-\|TraB-family-protein	gnl\|CDD\|350608	cd14726, TraB_PrgY-like, TraB/PryY confer plasmid-borne pheromone resistance. TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.	1.36539e-70
NC_008554.1\|WP_011697733.1\|1069758_1070754_+\|adenosyl-hopene-transferase-HpnH	gnl\|CDD\|274595	TIGR03470, HpnH, hopanoid biosynthesis associated radical SAM protein HpnH. The sequences represented by this model are members of the radical SAM superfamily of enzymes (pfam04055). These enzymes utilize an iron-sulfur redox cluster and S-adenosylmethionine to carry out diverse radical mediated reactions. The members of this clade are frequently found in the same locus as squalene-hopene cyclase (SHC, TIGR01507) and other genes associated with the biosynthesis of hopanoid natural products. The linkage between SHC and this radical SAM enzyme is strong; one is nearly always observed in the same genome where the other is found. A hopanoid biosynthesis locus was described in Zymomonas mobilis consisting of the genes HpnA-E and SHC (HpnF). Continuing past SHC are found a phosphorylase enzyme (ZMO0873, i.e. HpnG, TIGR03468) and this radical SAM enzyme (ZMO0874) which we name here HpnH. Granted, in Z. mobilis, HpnH is in a convergent orientation with respect to HpnA-G, but one gene beyond HpnH and running in the same convergent direction is IspH (ZM0875, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase), an essential enzyme of IPP biosynthesis and therefore essential for the biosynthesis of hopanoids. One of the well-described hopanoid intermediates is bacteriohopanetetrol. In the conversion from hopene several reactions must occur in the side chain for which a radical mechanism might be reasonable. These include the four (presumably anaerobic) hydroxylations and a methyl shift.	3.66307e-128
NC_008554.1\|WP_041441700.1\|1058987_1060334_-\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0

>NC_008554.1|WP_041441700.1|1058987_1060334_-|replication-associated-recombination-protein-A
MNLFLGRSSHPVRENAPLAERMRPGSLDEFVGQDHLLGRGKILDRVIRSRRFQSFVLWGPPGSGKTTLAAIIAAQTQTHMIHLSAVMAGTREIREAVTEAKQVWAKQKLRTWLFMDEIHRLNKAQQDTLLPHIENGTLLLLGATTENPSFEIIRPLLSRARVLVLNHLSDAELGNIVHRALEDRDRGLGNFPSRLTEDAEAFLLSAAGGDARIALNALEVAVLTTPPDPQNIRLVDLNAVQEALQRKAVHYDKGGEEHFNLISALHKSVRGSDPDAALYWLARMLDAGEEPLYLARRAIRMASEDIGLADPFALVEAVSAFQTYQVLGSPEGELALAQAIVYLCLAPKSNKIYEAFGNARELAGKTGSAPVPPHIRNAPTQLLKTLGYGRNYRYPHDDPEGWVAETYFPQNLAGTVFYHPTNRGWEGRWREILEKRRARVRQTEDPSK
>NC_008554.1|WP_011697724.1|1057476_1058949_-|two-component-sensor-histidine-kinase
MATIDDKRRTLESVKPFKLVKYVAVSSLMVIIVCTVLISGFITQRGRAILLHKSEQYALLVAENLNHQVFFQFTLPTLIAEGEIRLSRPSQYDRLDKVVRNTIHGFAVKQVNIYDPEQVLTYSTDKERIGTKGDIGADFERALKEQSVSRLSVDETLFLGISWGAGDNELKTYLPMWEERPMSLKKGKVLGVFEITQDVTADYRIIHRFQWIIVSSILIFVGILFLTILMIARRADRIISLRARERERLEEKLHQSERLAALGEMIAGVSHEIRNPLGIIRSTAELLNDRIEDERQKRFSSIIVEESTRLNDILTEFLDFARPKAIRPAQCRIEEILERNLKVLEAEFQRLNVTVERDYRTGAYSLEADCDLLFRAFVNLLANALQAMPQGGMLQVRTEVLNGKGGPRQVEVQIKDTGHGIPSDVRKKIFNPFFTTREKGTGLGLAIVQNIVDNHNGDIEVVSREGEGTAIIIRLPLIQSPHGSGDGTPE
>NC_008554.1|WP_011697723.1|1055967_1057476_-|sigma-54-interacting-transcriptional-regulator
METILIVDDEKNYLLVLEDLLVEDGYQVITADSAVKGLETVATTDLDVVITDMKMPGMDGMAFLEGIHARNSDLPVIMMTAYGSVEKAVEAMRMGAFDYILKPFKNEELKLTIRKAIDHYRLVCENRQLTQELKERYQFSNIIGKSAPMQRIYQLIEKVAPTKATVLVTGESGTGKELIARAIHYNSTRHDRAFISVNCGALPETLLESELFGHEKGAFTGAAIQRKGRFELAHEGTLFLDEISEMSPPLQVKLLRILQEMEFERVGGSQTIKVDVRVVAASNRNLKDEVATGRFRADLFYRLNVVHVALPPLRGRIDDIPLLVNHFLAKYTPQSKGKGMSISPEAFRVLLEYHWPGNVRELENVIERAVILCNGQEIMIRDLPAEIREPRAVPSPEATPSTEGPTLQPADFPPGGEADTRMPPLSPGERLQRTGFKPRQHKAMEFIENHGFITNKYYSQLCNVSERQALRELNELVDAGTLDRIGKGRACRYVLRGRGIGG
>NC_008554.1|WP_041439828.1|1055117_1055594_+|ribonuclease-HI
MPETPAIRKHVEIFADGACRGNPGPGGWGAVLRYHGKEKELSGYAEYTTNNQMELAAVIQALRALKEPCRVTITTDSRYLRDGISLWIHKWKQNGWKTRVKTDVRNKELWIALDEACLPHEIDWQWVKGHSGHPENERCDALARAAIDRHLREAATEE
>NC_008554.1|WP_011697721.1|1054013_1055069_+|phosphoesterase-domain-containing-protein
MDQRPTSSTLRRAAKRRPAKERLAEFHSCFHSKDSVLIIIDPDPDAIGSALAVKRLLWHRVQSATIGMIRPIKRLNNITMARLLKLPLVLMRRVPSEPFTKCVLVDGQPNHNDFFRQLSYTAVIDHHPLHETFASLFSDVRPEYGSTSSIMTEYLKAARIKPSKTLATALLYGIKTDTRSFERHTIVEDIEAFRYLFPLADHNILRKVEISDLSLKDLKVFDKAFERKYIIKDRLFAHLDEVPSADILVELAEFFLKIHDISWSIVSGIYDDNLIVIIRNDGYRKDAGKVIRKAFDSLGTAGGHSAMARAEVPLERLKEVIEKRTSATIENFVRKQLSPFAAGKSQKRGVT
>NC_008554.1|WP_011697720.1|1053479_1053668_+|CooT-family-nickel-binding-protein
MCEANAYLMKDGKEELLMANVDILRPEGNVVYLMDIFGEQRWVEAAIKEMNLVRHRIVLEKA
>NC_008554.1|WP_011697718.1|1051198_1052452_-|4Fe-4S-dicluster-domain-containing-protein
MREIEKVMYQEKPPAAADPDTLLFVQVDPEKCQGCGECDNHCPTGAVQARDPAGVRHVVSPAACINCGQCLVNCPHGAVYETVSYVDEITARLKDPATVAVSMPAPAVRYALGECFGYPTGAYVGGKMHAALKQLGFRFVWDNEYTADVTIMEEGTELLQRISKPDRHKPLPQFTSCCPGWVKFMECYYPDLLPHLSTCKSPIGMLGALAKTYGAQETKTPRDRMYTVSIMPCIAKKFEGLRPEMAASGCRDIDATITTRELAFMIKQAGIDFKSLPDMAPDPILGMSTGAATIFATSGGVMEAALRLAYEVLSKQKLPSPDIKVVRTHEGINTADIKVPRFGTVKVAVASGLANAAKLCDEVRAGKSPYHFIEIMTCPGGCVNGGGQPMDPRIRQASLLKRTIASVKKRYNLRTTG
>NC_008554.1|WP_011697717.1|1050837_1051185_-|iron-hydrogenase-small-subunit
MQKTTVQMTRRAFIRAAGLAAGYALVGFHLTKDALAAALDFAGLRQKAVYQADAEIYKSRKSQDNPMVKKLYDKNRGFLAKGPCGHKSHELLHTHYQDRSAGVKALKSVGVKLKI
>NC_008554.1|WP_011697716.1|1049849_1050338_-|NAD(P)H-dependent-oxidoreductase-subunit-E
MNGCECTPTDAALVKGLARIIEPYRGQPNSLIQVLAKAQEYIGYLPKWVQVQVAEGLGLSLQEIYGVTTFYAFFSLIPRGRHKLSVCAGTACYVKGTKNVLKGVRDAIGIKPGQTTPDSRFTMEIVRCIGACGLAPAVIVNGKDVHGRLEAEQIPEILSLYE
>NC_008554.1|WP_011697715.1|1048013_1049732_-|NADH-quinone-oxidoreductase-subunit-NuoF
MKSLDELAIIKESAQETLQIRYGKPGVLHKAHIMVCGGQGCISSKCAEVVDAIREALKKHNFSDHVKVVLTGCMGPCDMGPVAVVFPDAVFYRRLKPKDAEAIVLEHIIGGQPVTRLLYRVPGEKDPVPSMYDIELFKKQERIVLRNTLYIDPLSIEEYIGRDGYAALAKALTRMRPGEVVEEIKRSGLRGRGGAGFSTGMKWSFSAAAAGTPKYVVCNGDEGDPGAFMDRSVLEGDPHSVIEGMAICGRAIGAEQGYVYVRAEYPLAIERLEHAIRKAREFGLLGKDIFGTGFNFDIEIRIGAGAFVCGEETALLASVEGRRGEPRPRPPFPAIEGVFGKPTVINNVETWANIPAIIFKGADWFASIGTPKSKGTKVFALAGKITNTGIVEVPMGTTLREMVFDIGGGIPKKKEFKAVQTGGPSGGCIPARHLDTPIDYDSLGALGAIMGSGGMIVMDQDTCMVDIAKFFLEFCVDESCGKCSPCRIGTKRMHEILERISTGHGREGDIELLVELATTIKTTALCGLGQTAPNPVLSTIRYFRDEYEQHIRDHVCVAKVCDFANGDPDASE
>NC_008554.1|WP_011697726.1|1060878_1061580_-|ABC-transporter-ATP-binding-protein
MLEIMDLHVFYGGIHALKGIRLAVGEGRIVTLIGSNGAGKSTTLRSIVGLVKPQAGSVRFRGEELTRLSTHQIIQRGIGISPEGRHVFANLTVLENLELGAYNRTAAEFSGQLERVYSLFPRLRERCRQLAGTLSGGEQQMVAFGRALMGRPKLVLLDEPSLGLAPLVVEEVFQAIEAVRKDGATVLLVEQNAMASLRIADYAYVLETGRVILEGEGRVLLEDEKVIKAYLGE
>NC_008554.1|WP_011697727.1|1061572_1062346_-|ABC-transporter-ATP-binding-protein
MNSFLSLEKIVVQFGGLTAVNDFSLRLEPGELVGLIGPNGAGKTTVFNIITGFLSPTSGRVRWLDHDITGLPAHRITALGIARTFQNIRLFANMSVLENVMVSFHHNVRSHSWQAMLGTPGSAREERRQRTGAMQVLEEMNLTRFAAEKAGALPYGQQRRLEIARALAASPRLLLLDEPAAGMNPLETMELARLIRHLMKKYKLTVLLIEHDMKFVMRLCERIKVLDYGHSIAEGTPREIQDNPAVVKAYLGSVKHA
>NC_008554.1|WP_011697728.1|1062365_1063403_-|branched-chain-amino-acid-ABC-transporter-permease
MEDDNRKKAFNYAALLLAACVIYAFSRYGSEYHIRILNNMAVFIALAVSYNLVNGFCGILHLGPNGFIAIGAYTAALLTMSPAEKQLNFIIEPLIWPLNVIQVPFALSLVAAGLVAGLFALAISFPVFRVRGDYLAIVTLGFGEVVRVLCNAFQNVTNGPLGLKGLVPHTNLWWSWGVAIATIIVVNRLMNSSYGRAMKAIREDETAARSVGIDPFRHLLLAFVISAFISGVAGGLLAHLITTISPTLFTFFLTFNLLIMIVVGGLGSTTGAVVGAALFAWGGEALRIVERPMDLGIVIIPGIPGMRMVVFSFILMLVIIFARRGIMGQNEFSWDRIARLKAREH
>NC_008554.1|WP_041441704.1|1065174_1066047_-|branched-chain-amino-acid-ABC-transporter-permease
MTPMMMQQLINGVSLGSLYALVAIGYTMVYGILRLINFAHGDLLMVAAYAAIYGVAIFALPWYVGFPTAILITGAMGILLDRAAYRPLRNAPRISLLISAIGASFFLENVALVVIGGVPKAFPRPDMFSAVIEAFGLRIQVLTIYTPIVTALLVLGLLYVVYRTRVGKAMRAASKDFETTRLMGINLDRVISITFLLGSTLAAAGGIMWAMKYPQVNPLMGVFPGLKAFIAAVLGGIGSIVGAVIGGFLLGLGEVLIVAALPGLSQYRDAFAFVILILVLLFRPTGIMGE
>NC_008554.1|WP_011697730.1|1066390_1067518_-|ABC-transporter-substrate-binding-protein
MKKRGLLLLALTLSLLPGTGSLALASDTIKIGLYLPMTGGVAAYGEMEWAGIQIARDMEPQVLGKKIDLVLLDTKSDKIEATNAMTLLVEKEKVAGIIGEAISGNTMAGNRISEAAGIPSVSPSATSVLVNQGKKFAFRACFIDPLQGEVAARFAVNNLKAKSAAVIIDNAQDYCVGLAKFFETEFVKLGGKVLSKTYIQTGDQDFSAQLSSVQAVKPDIIYAPNYYTEDALLAKQARDLGIVCPILTGDGAQADTLIQVGGKAVEDMYFTAHFHKDAATTDRAAEFMKRYKEKHNKEADAFQALGADAYFLLVDAVRRAGSTDGARVRDALASTKDFKGVSGTITMGEEGNPIKSMVILKVANGKFVYVTTINP
>NC_008554.1|WP_011697731.1|1067619_1068351_-|TraB-family-protein
MSESVDTHRFFFDDKEFILIGTAHVSRDSADLTGRIIEEEKPDTVCLELCEARYRALIEGGSSGRGSFAGLLGSGNWTLLVSSAMLLYFQKRIGDKLGVKPGDEMRRAVEAANAVGADIRLIDRDARTTLLRAWTPMKRKDKIRLFREFFSALKDISALKEKDIEEMKRGDALETLVAEFGDTFPWLRHVLIDERDLILAHRIRTSPGRKIVAVVGAAHVQGILANWDKPVDMEQLERIPAKR
>NC_008554.1|WP_011697732.1|1068741_1069728_+|NAD-dependent-epimerase/dehydratase-family-protein
MPTAFITGATGFIGCHVARLLLEAGWKVRALRRERSVLPPELTDADWRVGDMRDPGSMTEAMEGCDAVFHVAADYRLWARNPGEIYENNVTGTANVLEAALKNGVPRVVYTSSVGALGLNADGSPALETTPVSIEDMIGHYKRSKYLAERRAEDYLARGLPIVMVHPSTPVGPGDRKPTPTGKIIVDFLNGKMPAYLNTGLNLIHVADVAAGHLLAFDRGKIGEKYILGNTNLTLAEIFQRLEGISGVKAPRVRLPHRPILLLAHILQGVSRITGKEPLVPLEGVRMARKYMFFDASKAVRELGLPRTPVDSALADAVAWFRQNGYAR
>NC_008554.1|WP_011697733.1|1069758_1070754_+|adenosyl-hopene-transferase-HpnH
MRFPMSLYLSMTGYLLRNKLRGVEKFPLVLMLEPTHRCNLTCSGCGRIREYHDTLHQEMTLDECLRSVDESPSPVVTITGGEPLLYSRIQALVDSVLARKKHIYFCTNALLLEESLPMFQPHSHFTWNVHFDGTETVHDAIIGRPGGFQKALAGVRAAKARGFRVSTNTTVYRETDVDDLERLFEQLAAAGVDGILAAPGFSYEEVIRDVFMTRNEIMEKFRRIRTWQKRFPLISNPIYLDFLSGQRSLQCTPWGNPTRNSQGWKSPCYLITDTHYATFDELMKKTDWDYYASGQDQRCAQCMVHCGYEPTVVRQMTGRDLFRMLKWNLDV
>NC_008554.1|WP_011697734.1|1070746_1071667_+|carotenoid-biosynthesis-protein
MSDFFRLLLGTMVLRPYVFVFLAAYLVAASAHLGWKKALAYVPLGYCIAWISEFSSIHWGFPYGDYYYIPATIDRELWVFGVPFMDSLSYVFLSYCSYSTAIFLLSPVYIGKGTVLILETRRLRRSWQTVVLGAFLFVLLDIIIDPVALQGYRWFLGQIYGYRHQGLYFGIPMSNFGGWLLVGLVMMAALSRLDRISALESSAAPFPLNAIPGVRLFGPLLYCSVLAFNLAVTFWIGEHLLGLVGCLILFFSGLTAAFWTRYKIENLSAGAVYAHFRDFPSPSEYRVVEPFLQAAVPDESIQVGGG
>NC_008554.1|WP_011697735.1|1071586_1072396_-|purine-phosphorylase-1
MKILILTALAREHSHFRHITGSWRRSRRGPFAFRELNGDDKTLFLVDSGMGANPVRETLDWAVDHIAPELLLSAGYGGSISNEFQVGDVVLGAMFCGELTPEGGEETRCLALPIAEKRGRLPGQRPIRPARIVTVARPRAKTELRARYADTPSVIDMETLYAARAAYEKGIPFLSLRAVSDGPEHEIEYDLDAISNPAGKIRIGGVLSLIRSNPRVIGAFYRSWKRSVEAGRRLGECLAELLLLPAADLNRFVGDCRLEERLDHTILGR

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Crispr_ID: NC_008554_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_8

1111772-1111869

Orphan

Consensus_repeat	Method
TTACCTAGAAAATAGATTCCCGGGTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_8

>merge|NC_008554|8|1111772-1111869|CRISPRCasFinder
TTACCTAGAAAATAGATTCCCGGGTGAAACTGTTTTCATGCTTCGCAGGTGAAGCACAGCCTCATGGATAATTACCTAGAAAATAGATTCCCGGGTGA

>NC_008554|8|8|1111772-1111869|CRISPRCasFinder
TTACCTAGAAAATAGATTCCCGGGTGA	AACTGTTTTCATGCTTCGCAGGTGAAGCACAGCCTCATGGATAA
TTACCTAGAAAATAGATTCCCGGGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011697767.1\|1107849_1108875_-\|haloacid-dehalogenase-like-hydrolase	unknown	unknown	gnl\|CDD\|378932
NC_008554.1\|WP_011697775.1\|1119936_1121058_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|377314
NC_008554.1\|WP_011697760.1\|1101106_1101709_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_008554.1\|WP_011697772.1\|1115637_1116813_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_150109431.1\|1104490_1104961_+\|OsmC-family-protein	unknown	unknown	gnl\|CDD\|376823
NC_008554.1\|WP_011697771.1\|1114426_1115281_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NC_008554.1\|WP_011697776.1\|1121386_1123432_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|131081
NC_008554.1\|WP_011697766.1\|1105883_1107587_-\|TrkA-domain-containing-protein	unknown	unknown	gnl\|CDD\|223643
NC_008554.1\|WP_011697774.1\|1118156_1119764_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|376570
NC_008554.1\|WP_011697778.1\|1124646_1125786_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223594
NC_008554.1\|WP_011697761.1\|1102233_1102668_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350245
NC_008554.1\|WP_011697762.1\|1102664_1102931_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697765.1\|1105141_1105498_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011697773.1\|1117065_1117551_+\|membrane-protein	unknown	unknown	gnl\|CDD\|377190
NC_008554.1\|WP_011697770.1\|1112515_1114006_+\|peptidase-C1	unknown	unknown	gnl\|CDD\|227207
NC_008554.1\|WP_011697768.1\|1109256_1111107_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NC_008554.1\|WP_011697763.1\|1103443_1104331_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_008554.1\|WP_083764181.1\|1100245_1100827_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_008554.1\|WP_011697779.1\|1125940_1126639_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|198414
NC_008554.1\|WP_011697777.1\|1123633_1124608_+\|peptidase-M19	unknown	unknown	gnl\|CDD\|238626

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011697767.1\|1107849_1108875_-\|haloacid-dehalogenase-like-hydrolase	gnl\|CDD\|378932	pfam12710, HAD, haloacid dehalogenase-like hydrolase.	2.02468e-11
NC_008554.1\|WP_011697775.1\|1119936_1121058_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|377314	pfam04339, FemAB_like, Peptidogalycan biosysnthesis/recognition. FemAB_like is a family of both baterial and Viridiplantae proteins with responsibility for building interpeptide bridges in peptidoglycan. Such a function is feasible for bacteria but less likely for the plant members of this family. Perhaps the plant-members are using homologous proteins to recognize bacterial peptidoglcans as part of their innate immune system.	2.57116e-101
NC_008554.1\|WP_011697773.1\|1117065_1117551_+\|membrane-protein	gnl\|CDD\|377190	pfam04008, Adenosine_kin, Adenosine specific kinase. The structure of a member of this family from the hyperthermophilic archaeon Pyrobaculum aerophilum contains a modified histidine residue which is interpreted as stable phosphorylation. In vitro binding studies confirmed that adenosine and AMP but not ADP or ATP bind to the protein.	3.00715e-107
NC_008554.1\|WP_150109431.1\|1104490_1104961_+\|OsmC-family-protein	gnl\|CDD\|376823	pfam02566, OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.	1.51596e-17
NC_008554.1\|WP_011697766.1\|1105883_1107587_-\|TrkA-domain-containing-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	1.98528e-22
NC_008554.1\|WP_011697776.1\|1121386_1123432_+\|radical-SAM-protein	gnl\|CDD\|131081	TIGR02026, BchE, magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase. This model represents the cobalamin-dependent oxidative cyclase, a radical SAM enzyme responsible for forming the distinctive E-ring of the chlorin ring system under anaerobic conditions. This step is essential in the biosynthesis of both bacteriochlorophyll and chlorophyll under anaerobic conditions (a separate enzyme, AcsF, acts under aerobic conditions). This model identifies two clades of sequences, one from photosynthetic, non-cyanobacterial bacteria and another including Synechocystis and several non-photosynthetic bacteria. The function of the Synechocystis gene is supported by gene clustering with other photosynthetic genes, so the purpose of the gene in the non-photosynthetic bacteria is uncertain. Note that homologs of this gene are not found in plants which rely solely on the aerobic cyclase.	1.44324e-38
NC_008554.1\|WP_011697771.1\|1114426_1115281_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	1.03998e-21
NC_008554.1\|WP_011697774.1\|1118156_1119764_+\|GAF-domain-containing-protein	gnl\|CDD\|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	9.04017e-20
NC_008554.1\|WP_011697778.1\|1124646_1125786_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	8.18766e-86
NC_008554.1\|WP_011697761.1\|1102233_1102668_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350245	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC25, VapC29, VapC33, VapC37, and VapC39 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.66676e-47
NC_008554.1\|WP_011697760.1\|1101106_1101709_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	2.01444e-26
NC_008554.1\|WP_011697770.1\|1112515_1114006_+\|peptidase-C1	gnl\|CDD\|227207	COG4870, COG4870, Cysteine protease [Posttranslational modification, protein turnover, chaperones].	2.51173e-66
NC_008554.1\|WP_011697768.1\|1109256_1111107_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NC_008554.1\|WP_011697763.1\|1103443_1104331_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.08907e-51
NC_008554.1\|WP_083764181.1\|1100245_1100827_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.21916e-29
NC_008554.1\|WP_011697779.1\|1125940_1126639_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|198414	cd10432, BI-1-like_bacterial, Bacterial BAX inhibitor (BI)-1/YccA-like proteins. This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	2.80833e-77
NC_008554.1\|WP_011697777.1\|1123633_1124608_+\|peptidase-M19	gnl\|CDD\|238626	cd01301, rDP_like, renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Although the biological function of the enzyme is still unknown, it has been suggested to play a role in the renal glutathione metabolism.	6.42937e-76

>NC_008554.1|WP_011697768.1|1109256_1111107_-|phosphoenolpyruvate-carboxykinase-(GTP)
MKEFQLTGGKTNHEAMLRWIQETARLCKPDRVHLCDGSETENRELCDQMVRSGTFIRLNEEKRSNCFLCRSDPADVARVESRTFVCSNSKNAAGPTNNWMHPREMKEILNGLFDGCMRGRTMYVIPFSMGPLGSHIAHIGVQITDSPYVVVSMRIMTRMGQGALDVLGRKGPFVRCFHSVGSPLEPGGKDVPWPCNPANTYISHFPEERAIYSFGSGYGGNALLGKKCFALRIASCMARDEGWLAEHMLIVGVQSPRGERTYVAGAFPSACGKTNFSMMVPPKGFEGWKVFTIGDDIAWIKPGADGALRAINPEAGFFGVAPGTSMKSNPNAMMTLNKNCIFTNVALTDDGDVWWEGMTDDPPSHLIDWTGKDWTPGCGRVAAHPNSRFTAPISQCPTFDPNWDNPDGVPIKAFIFGGRISKNVPLIFQGYNWTHGVYLAATMGSEATAAAEATLPPMRRDPMAMLPFCGYNMAEYWNHWLDIGRQLPDPPRIFRVNWFRRDKQGKFLWPGFGENMRVLKWIVDRVHGRGYGVESPLGYVPRYQDIEWEGLDLDPDLFCELMTVEREQAIIEARSHEDLFDKFFDRLPKEFVHTRELFKSRVWRSPEIWNPGNGVC
>NC_008554.1|WP_011697767.1|1107849_1108875_-|haloacid-dehalogenase-like-hydrolase
MKLNRGRPGTLAVLLVLTSLVFGCARLPVAAEDPLPSWNEGAVKDGILDFVARVSTPGGKDFVPVPERVAAFDNDGTLWAEQPIYFQFAFTLDRVKTLAAEHPEWRSEAPFKWVLDGDFQALFDADEKDIFKLILATHAGMTTDEFEGTVREWLATARHPRFKRPYTECVYQPMVELLRYLRANGFKTFIVSGGWSDFMRPWIERVYGIPPEQVVGSGLKLEYEMRGGTSVLLILPEVDFLNDRAGKPVGIHRFIGRRPIFSFGNSDGDLQMLQWTADGKGARFMGLVRHTDAEREWAYDRASPIGRLDKALDEAQAKGWTVVDMKRDWAVVFPTRGSVGR
>NC_008554.1|WP_011697766.1|1105883_1107587_-|TrkA-domain-containing-protein
MKLLTTQLSYLLSQQQTRRNLKALLKFVLFLTAVVLLYAVVFHWIMVTIEKRDHSWLTGIYWTLTVMSTLGFGDITFHSDVGRAFSIVVLLSGIVLLLIVLPFAFIRFFYAPWLEAQMRLRAPREVPHDMSGHVIICRYETVAQGLIRKLKAFRIPYYVLEPDATLAANLYEEGVSVVTGEVDNSTTYAALRASEARMVLANADDATNTNITLTVRETAAKAPVVAIVESIDSVDILELAGATHVLPLKQRLGEHLAYRVTAERTNVHVIGTFRDLRIAEFPVQNTPLAGCMIRETRLRQRTGVNVVGVWERGHLLPAKPDTVLAESSVPVILGTAGQIADMESFLVTENVNRNPILVIGCGNVGYAVTCALKNKSLAFHVVERDKAVEERSSSIAGELFIGDAADRSVLMRAGLAEAPSAVITTNDDAMNIYLTVYCRRLNPRLRIVSRITHERNLEAIHRAGADFVLSYASLGAESIFSILQERELIMLGEGIDLFVAKVPESLAGKSLGKTNIGAETGLTVIAIQKGGDVVTNPPASAVIDSDSELLMIGSSEQRDEFAARFGV
>NC_008554.1|WP_011697765.1|1105141_1105498_+|hypothetical-protein
MRHDSAAAVQSPRMAGANAKSIVEAGAMICMCSMGPEYKMEVLEAAENRTVIKILECPWKNRMNEFGIPHDLLSTCDAAFWDHFVKDLNSNVAMRHGKQMHRGDAYCEWIFEDKRKTE
>NC_008554.1|WP_150109431.1|1104490_1104961_+|OsmC-family-protein
MKEQENRSETGMEPLQVSTVVLAGANRRMLARTRDHEITLDVPKERGGDNAGPTPPECLTMALGGCVLNICRVLAMQKRIVLDDIQVTIKGEIDPSKAFGIPTEKRAGFTNLSVRLKLDSELTETEKEEFRLELIGRCPLCDTLGNATPLQISFEN
>NC_008554.1|WP_011697763.1|1103443_1104331_-|LysR-family-transcriptional-regulator
MEMQRLQTFRTVAALMNFNQAANILNCAQSTVSAQIKALENEIGTMLFKRIGKSVQLTEAGAKMLIYADKLLAIKDEALAEVRGNKPGSGMLTLRMPQTMATYYLPHILRSYQPRFPGIRLDITSCALHSLENELRIATVDLAFLFAESIGAKNLESEFLGSDPLFFVTYPGHPLSTRRRVDFKNLEGEVLLLPKSDCGYRMVLEQTLTAEKVTPATIIEMNSIEAIKQAIMAGLGVTVIPEIAVRSEIKEGRIARIAWVDDLETGILMIRYRDKWCPPPLDAFMDMVRGFFRAR
>NC_008554.1|WP_011697762.1|1102664_1102931_-|hypothetical-protein
MRTTLTIDDEIAVSLKDLAHRSGKSFRQVVNDALRKGAHALENPEARPYRLSPTSLGLLRSNINLDKALNLADEREDAAIAMKLELRK
>NC_008554.1|WP_011697761.1|1102233_1102668_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MILVDVNLLLYAVNQDLPQHARSRTWLETVLSGSESVGLPWVVIRAFLRITTNARIFERPLSVERAVAYVEEWLAQPVATTVTPGKSHWMILRNLLLDSGTGGNLTTDAHIAALAIEYGHTVYSTDNDFKRFQGLRHINPLAVQ
>NC_008554.1|WP_011697760.1|1101106_1101709_+|flavodoxin-family-protein
MNIVCLLGSPREKSNSSAIAKRFMDTAEKLGAKTDTYLLNELKYRGCQACMACKTKLEKCALKDDLSRVLAAIQDCDVLVMASPVYFGEVTSQLKACIDRMYSFLKLDYGVNPSPVRFAPGKVLVFALVQGHPNEKLFRDVFDRYDYFMKWWGFKESHLIRACGVFEAGAIETRRDILALAEEIARKVCSSKSTTPVNTN
>NC_008554.1|WP_083764181.1|1100245_1100827_-|helix-turn-helix-transcriptional-regulator
MAIGGKWKPVVLYRLGRERIRRFSDLRRDIPEVTERMLSRQSRELEQDGLIHREVYRQVPPKVEYPLTKLGCGLIPILLSMRECARYRERFRKKSLRHEGFPARGSSGHFPPVSLNVPAIISREASASSAGTAISRDKARAMASPFARGTRKTSCSTFFGMLDTSSSPTTLRPRNERSTGLPGLDAPRKVVFT
>NC_008554.1|WP_011697770.1|1112515_1114006_+|peptidase-C1
MSASKRNTAFRMLCTIGLVFVVGIFFAMSPSLSQAQQLQQAPYNPDFLKYMEQVRQGKAPLKVTEEGFALGYIPPPIDLSYAKNLPATASEAAAVEAVTYPASFDLRTQNRVTPVKNQGACGSCWAFATMASIESKLKGPTGTGPTTNYSEQHPNATHGFDWPECEGGNDYISMAYLGRWSGPVNEADVPYPYAVDDTAAVVRKHIQDVDQIKDRANFTDNDRVKAAVTTHGALYISFKWLDTRYNATKYAYWNNGTTGEGHAVAIIGWNDAFPKTNFKKVGTALPAGNGAFLVKNSWGATWGNKGYFWMSYYDKSLQTGTSFRGIQAVTNYKRNYQYDPLGWVSSVGISSPTLWGANIFTAATGANKIKAVSFYTGAPNTKVTIYVRNNVSATNPKSGTQVGTAVTKTIPTMGYHTVVFSTPKTVTAGKKFSVLIKFNTPGFNYPLPIELAVADYSSGAKASANQSFYSSDGNTWYDITTYDPTCNVCIKAFGSS
>NC_008554.1|WP_011697771.1|1114426_1115281_+|rhomboid-family-intramembrane-serine-protease
MDIQGRRSILCPNCRRLISTDETSCPHCGLSRPGSRWRNNLWTGNFFSSHQLVRTIIFINAGMFVLSLIIAPSSAGFSMNPLNFLSPGSRSLLLLGATGRIPIDQFDRWWTLLSASYLHGSILHILFNMMAFSQIAPLIVHEYGASRTLAIYTLSGIGGYVLSYFAGTAVTLGASAAVCGLIGAALYYGRSRGGQFGQLVYRQVSGWVIGLFIFGFLFPGIDNWAHGGGLLTGILAGFVLGYQERQPERLLHKTVGNLCVIATALTLVYAVGTSFLIIFRVGLG
>NC_008554.1|WP_011697772.1|1115637_1116813_+|hypothetical-protein
MKPDARFSIAEEIMLDFAGRTGLSPSGEPPRRYLWTDAFAVCNYLELHRRSGAARYRDLALLLVDQVHHVLGRHRPDDSRSGWISGMEECEGEIHPTFGGLRIGKKLNERAPNDRIDERLEWDRDGQYYHYLTKWMHALSRVSRVTENMKYNTWAVELARTAHRGFLYAPSFGGRKMMYWKMNIDLSAPLVRSMGQHDPLDGFITYNELAACAAKAPPWAGEDVLGKEIADIEKICLGKTWTTDDPLGIGGLLFDAFRVVQLMTGGSFEGNDLLTALLDAARVGLNACLRRNSLELPADYRLAFRELGLSIGLKAIDRLWRLIERKPDLFRERQELRARVEALMRYTPLVEIIEGFWLDDGNRQAESWTEHEDINSVMLATSLIPDGFLTL
>NC_008554.1|WP_011697773.1|1117065_1117551_+|membrane-protein
MQIKTVGIEKPEPINFILGQTHFIKSVEDIHEALVSAVPGIKFGLGFCEASGKCLVRLTGTDPDMVELARRNASAVAAGHTFIIFLGEGFFPVNVLNAVKMVPEVCRIFCATANPTQVLIAETELGRGVIGVVDGFAPKGIEGEEDVKWRKDFLRMIGYKL
>NC_008554.1|WP_011697774.1|1118156_1119764_+|GAF-domain-containing-protein
MGSGAVLLNKVLERRLRRADIRLILDTLCRDDQDTFLDELSDVLRKLITLTEVSTRLSESLSLDVLLSRLIEITTESLEAYRGTVFLHDKDTNELYSRAALGNLIQEIRIPIHQGIVGNVFVTGQPVNIDDAYADARFNPEMDKKTGYKTRNVLAVPIKTKDRQIVGVIQLLNKKSGSFSENDLLMLEAIGGQAAAALQNAQTYEIVSRTRHEESMLFQQVGKERREEAQFFKFTREIFFELRMESLFKKITETTATLLAAERSVLYLHDDKANELWSMTTHESQTVRVRFPSHLGIAGSALITGEIVNIPDTAKLPSSIFPVDIEPGFPAHSVLCAPIKTSQGKVVGVIQVRNKKGGPFDRADESRLEIFAGYASIAIRNAELFEATLKSANYFESIFRTLPNGLLLMNANRTIEDCNDAASEILDLPKDRIVGSQVGDIFLGDSKCVTNAVERVVQSAKPEVGMYARLNLLEGRVVTLNLSVLPILADHDRIAGAILALDPLVTRGTYRTLQGYRNQNPPAYIPINSVISTGS
>NC_008554.1|WP_011697775.1|1119936_1121058_-|GNAT-family-N-acetyltransferase
MMAVHFETFASAREVGGEVWNGLAADANPMMEWEYFCALEESGSVGPEKGYFPAHLVLYCDDRPVALAPLYRRDRAWVEFGDGGLIEFLSQLSGLPYQRGLVGAVPFTPVPGYRFLCLGDRSPLEIFALMLDEIDRLCEAQDLSTSRIYFVASRGPALRHLLLQRGYTNLTAGYTLWFNRGYLSFNDYLGSFKSSRRTKIKREIRAIQDAGISFEMLDGREASQSDFLEMHRLYEKTWHKHMGNGLRPFLNGSFFRMLGDSFRHRVSFSVAMRGRRRLAMALFYHKAAELYGRYWGCTEEIPFLHFSSCYYFPIRHAIDRGFQMMDPGFGGEHKLIRGYETVPVHHFIKFHGERKRRVAAAILNRLQQVPGKG
>NC_008554.1|WP_011697776.1|1121386_1123432_+|radical-SAM-protein
MRIALVFPPFYLEPMYNMPPLGLIHLATNLAADGHDPFILDFPLDIRRGRLHLGKRIYADCASRILEEDPGMVGFSVQCTTFPGAVRIAQLVKAQNPGIKIVFGGHSASAVDIETLEAFPWIDAVVRGEGEITMSELASRCVRAEGLHGVRGLSFRDGGTVFRNGDRELIADLDELPLADYSFVPPFSTYRDSCGIPRSIAILEVGRGCPHHCIYCSQSVMWRRRQRTYSVPRLIREMRNLRDRYGAQCFLLAYDQFTARRSFVEQFCGTLIETGLNRVPWYCISRLDTVDAELLGLMREAGCESMCYGIDSGSKRTLAFIRKNIDGDILLRRVRETTDQGIVPTLSFVIGFPEEEREDIDATLELTLRTGVQGGINPLLQLATVLPGTDLFQGYADRLVRSVDTYFSLGIEFDGARRLRSDDELIDAHPAIFCSFYNLPCPAFPLETLNVLAVGFPLIVNFYPRSFLLLMLEAGESPSGLFFRFMDWLAQTGRKTDSTLSPRDCYNHFAAFTVETVASLDHLERHYLPEMIRYETMALEAGKFDSADTAFFMDLSGIGNLKPLLARNIVLGEFTFNLPDIILDIKHGVLDKTYSPSRTFMVFSHRANELDVKEINDFGMDLLRRCDGTTTVADISRDLFAAYGKESTHEAFFDLCVDAIRELAELNLVQPGSPHHLPERG
>NC_008554.1|WP_011697777.1|1123633_1124608_+|peptidase-M19
MTQPGSQTSALPVFAAIDGHVDLIYEMTRRHSNVPLRSIIDGAVTLAGMREGNVRAIAAALYCADSFNGQGSAAPYLRSLIDYAAAYFTGLDRIESPGDLQRCLEHEAFPGYLLLIENSDALLDLDLDELKNAGMRIAGLTHAGSNRLGDGNGVQCPQGLTAAGKRLVKELGARGFAIDVAHLADPGLADLLRLFDGPIVSSHTGFRFFCDTPRNLTRQQLGALFARDGIVGITVNPEMLSSKGRAGIEDVFRHIDWVAQKHGPDHVAIGSDFCGFDCPNADLWDISRLPLIAEVLRKRGYPDDAVERIMGGNWRRFYQALLAG
>NC_008554.1|WP_011697778.1|1124646_1125786_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MKTTKRYRALFPVTDRYAFLNHAAVSASSLRVRAAVVSFLDALVESGPVRYGEWMEGVAEARRRFARLINAEPGEIAFTGNTSDGLSIIAEGLDWKPGDAVLVPMPDFPANVYPWLNLERLGVQMRFYCKNLGRFGPAELEEAFRPGVRLLAVSSVDYATGFLCDLEAVGEFCREKGILFCVDAIQSLGAFALDVHKCGIHFLAAGAHKWLLGLMGSGALYISRDVDEMVRPGRVGWRSVVDENNFETLSLSLKKDALRFETGTGNVAGILGLGAALGLLLEVGIDTVSESILALNDRVLDGLRERSLEVVSPVEKKNRSGIISFIPPGNPQELFDFFNRRNVCVSRRGRYIRLSPHFYNNAEDIDAFLDALDAYRPTG
>NC_008554.1|WP_011697779.1|1125940_1126639_+|Bax-inhibitor-1/YccA-family-protein
MERQYYPQQDQVVAIQSDFVRRVYNWMGIGLATTAVVAMLTFSSSTTSRLLAQYPGLMLGLVLAELGLVIAISAGINRFRASSATLMFFIYSALNGVTLSVIFLVYAHSSIANTFFVTAGMFAIMSVYGYTTRTDLTSLGNFLFMGLIGIILASVVNIFLGSQSLDWIISCLGVIIFVGLTAYDTQSIKAMAHGGFADAETEQKAAVIGALRLYLDFINLFLMLLRLFGRRD

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Crispr_ID: NC_008554_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_9

1571261-1571348

Orphan

Consensus_repeat	Method
GCGGTCGCCGTGCGTGCGCGGGACAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_9

>merge|NC_008554|9|1571261-1571348|CRISPRCasFinder
GCGGTCGCCGTGCGTGCGCGGGACAGGCGTACCCCACCAGTAAACCATCAGTTCAACGCCGCGGTCGCCGTGCGTGCGCGGGACAGGC

>NC_008554|9|9|1571261-1571348|CRISPRCasFinder
GCGGTCGCCGTGCGTGCGCGGGACAGGC	GTACCCCACCAGTAAACCATCAGTTCAACGCC
GCGGTCGCCGTGCGTGCGCGGGACAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011698142.1\|1579130_1579745_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227950
NC_008554.1\|WP_011698134.1\|1569041_1570331_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_008554.1\|WP_150109450.1\|1571946_1575018_+\|formate-dehydrogenase-N-subunit-alpha	unknown	unknown	gnl\|CDD\|273689
NC_008554.1\|WP_011698138.1\|1575021_1575753_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319881
NC_008554.1\|WP_083763971.1\|1559536_1560535_-\|ParB-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|319266
NC_008554.1\|WP_011698145.1\|1581582_1581861_+\|cell-division-topological-specificity-factor-MinE	unknown	unknown	gnl\|CDD\|377128
NC_008554.1\|WP_011698130.1\|1564775_1566521_-\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NC_008554.1\|WP_011698129.1\|1564055_1564559_-\|calcium-binding-EF-hand-containing-protein	unknown	unknown	gnl\|CDD\|320024
NC_008554.1\|WP_011698126.1\|1560518_1561424_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NC_008554.1\|WP_011698147.1\|1582761_1582989_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376742
NC_008554.1\|WP_049766306.1\|1566945_1567407_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221
NC_008554.1\|WP_041440071.1\|1582150_1582390_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|291142
NC_008554.1\|WP_011698143.1\|1580040_1580703_+\|septum-site-determining-protein-MinC	unknown	unknown	gnl\|CDD\|179052
NC_008554.1\|WP_011698141.1\|1577229_1579134_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223504
NC_008554.1\|WP_011698144.1\|1580774_1581566_+\|septum-site-determining-protein-MinD	unknown	unknown	gnl\|CDD\|225447
NC_008554.1\|WP_011698132.1\|1567583_1568432_+\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|320695
NC_008554.1\|WP_011698128.1\|1562618_1564031_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|274129
NC_008554.1\|WP_011698127.1\|1561698_1562514_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225613
NC_008554.1\|WP_011698135.1\|1570638_1570986_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698139.1\|1575909_1576812_+\|formate-dehydrogenase-accessory-protein-FdhE	unknown	unknown	gnl\|CDD\|319975

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698132.1\|1567583_1568432_+\|zinc-metalloprotease-HtpX	gnl\|CDD\|320695	cd07336, M48B_HtpX_like, Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase. This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.	3.02751e-167
NC_008554.1\|WP_150109450.1\|1571946_1575018_+\|formate-dehydrogenase-N-subunit-alpha	gnl\|CDD\|273689	TIGR01553, Formate_dehydrogenase_major_subunit, formate dehydrogenase-N alpha subunit. This model describes a subset of formate dehydrogenase alpha chains found mainly in proteobacteria but also in Aquifex. The alpha chain contains domains for molybdopterin dinucleotide binding and molybdopterin oxidoreductase (pfam01568 and pfam00384, respectively). The holo-enzyme also contains beta and gamma subunits of 32 and 20 kDa. The enzyme catalyzes the oxidation of formate (produced from pyruvate during anaerobic growth) to carbon dioxide with the concomitant release of two electrons and two protons. The electrons are utilized mainly in the nitrate respiration by nitrate reductase. In E. coli and Salmonella, there are two forms of the formate dehydrogenase, one induced by nitrate which is strictly anaerobic (fdn), and one incuced during the transition from aerobic to anaerobic growth (fdo). This subunit is one of only three proteins in E. coli which contain selenocysteine. This model is well-defined, with a large, unpopulated trusted/noise gap. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	0
NC_008554.1\|WP_011698139.1\|1575909_1576812_+\|formate-dehydrogenase-accessory-protein-FdhE	gnl\|CDD\|319975	cd16341, FdhE, formate dehydrogenase accessory protein FdhE and similar proteins. This family contains formate dehydrogenase accessory protein FdhE and FdhE-like protein, found largely in gamma- and some beta-Proteobacteria, where the fdhE genes are almost always genetically-linked to the structural genes for formate dehydrogenases. FdhE is required for the assembly of formate dehydrogenase although not present in the final complex. In E. coli, FdhE interacts with the catalytic subunits of the respiratory formate dehydrogenases. Purification of recombinant FdhE demonstrates the protein is an iron-binding rubredoxin that can adopt monomeric and homodimeric forms. E. coli FdhE interacts with the catalytic subunits, FdnG and FdoG, of the Tat- dependent respiratory formate dehydrogenases. Site-directed mutagenesis has shown that conserved cysteine motifs are essential for the physiological activity of the FdhE protein and are also involved in Fe(III) ligation. The iron likely is redox active, suggesting that the switch from aerobic to anaerobic conditions may be important in modulating FdhE function. Alternatively, FdhE may be involved in an electron transfer reaction, similar to other rubredoxins.	4.01494e-55
NC_008554.1\|WP_083763971.1\|1559536_1560535_-\|ParB-N-terminal-domain-containing-protein	gnl\|CDD\|319266	cd16409, ParB_N_like, ParB N-terminal-like domain of bacterial and plasmid parABS partitioning systems. This family represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	5.97107e-05
NC_008554.1\|WP_011698145.1\|1581582_1581861_+\|cell-division-topological-specificity-factor-MinE	gnl\|CDD\|377128	pfam03776, MinE, Septum formation topological specificity factor MinE. The E. coli minicell locus was shown to code for three gene products (MinC, MinD, and MinE) whose coordinate action is required for proper placement of the division septum. The minE gene codes for a topological specificity factor that, in wild-type cells, prevents the division inhibitor from acting at internal division sites while permitting it to block septation at polar sites.	3.13616e-22
NC_008554.1\|WP_011698130.1\|1564775_1566521_-\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NC_008554.1\|WP_011698129.1\|1564055_1564559_-\|calcium-binding-EF-hand-containing-protein	gnl\|CDD\|320024	cd16226, EFh_CREC_Calumenin_like, EF-hand, calcium binding motif, found in calumenin, reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins. The family corresponds to a group of six EF-hand Ca2+-binding proteins, including calumenin (also known as crocalbin or CBP-50), reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins. Calumenin is an endo/sarcoplasmic reticulum (ER/SR) resident low-affinity Ca2+-binding protein that contains six EF-hand domains and a C-terminal SR retention signal His-Asp-Glu-Phe (HDEF) tetrapeptide. It functions as a novel regulator of SERCA2, and its expressional changes are tightly coupled with Ca2+-cycling of cardiomyocytes. It is also broadly involved in haemostasis and in the pathophysiology of thrombosis. Moreover, the extracellular calumenin acts as a suppressor of cell migration and tumor metastasis. RCN-1 is an endoplasmic reticulum resident Ca2+-binding protein with a carboxyl-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide signal. It acts as a potential negative regulator of B-RAF activation and can negatively modulate cardiomyocyte hypertrophy by inhibition of the mitogen-activated protein kinase signalling cascade. It also plays a key role in the development of doxorubicin-associated resistance. RCN-3 is a putative six EF-hand Ca2+-binding protein that contains five RXXR (X is any amino acid) motifs and a C-terminal ER retrieval signal HDEL tetrapeptide. The RXXR motif represents the target sequence of subtilisin-like proprotein convertases (SPCs). RCN-3 is specifically bound to the paired basic amino-acid-cleaving enzyme-4 (PACE4) precursor protein and plays an important role in the biosynthesis of PACE4.	6.88732e-06
NC_008554.1\|WP_011698126.1\|1560518_1561424_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NC_008554.1\|WP_011698147.1\|1582761_1582989_-\|hypothetical-protein	gnl\|CDD\|376742	pfam02229, PC4, Transcriptional Coactivator p15 (PC4). p15 has a bipartite structure composed of an amino-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain. The DNA-binding activity of the carboxy-terminal is disguised by the amino-terminal p15 domain. Activity is controlled by protein kinases that target the regulatory domain.	2.54852e-13
NC_008554.1\|WP_049766306.1\|1566945_1567407_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	3.72747e-24
NC_008554.1\|WP_041440071.1\|1582150_1582390_+\|hypothetical-protein	gnl\|CDD\|291142	pfam14451, Ub-Mut7C, Mut7-C ubiquitin. This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role.	5.67277e-07
NC_008554.1\|WP_011698143.1\|1580040_1580703_+\|septum-site-determining-protein-MinC	gnl\|CDD\|179052	PRK00513, minC, septum formation inhibitor; Reviewed.	1.22893e-44
NC_008554.1\|WP_011698141.1\|1577229_1579134_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|223504	COG0427, ACH1, Acetyl-CoA hydrolase [Energy production and conversion].	8.84869e-93
NC_008554.1\|WP_011698144.1\|1580774_1581566_+\|septum-site-determining-protein-MinD	gnl\|CDD\|225447	COG2894, MinD, Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning].	2.76394e-135
NC_008554.1\|WP_011698134.1\|1569041_1570331_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_008554.1\|WP_011698128.1\|1562618_1564031_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	2.10548e-58
NC_008554.1\|WP_011698127.1\|1561698_1562514_+\|hypothetical-protein	gnl\|CDD\|225613	COG3071, HemY, Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism].	0.00488079
NC_008554.1\|WP_011698138.1\|1575021_1575753_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319881	cd10559, W-FDH, tungsten-containing formate dehydrogenase, small subunit. This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.	3.4035e-124
NC_008554.1\|WP_011698142.1\|1579130_1579745_+\|hypothetical-protein	gnl\|CDD\|227950	COG5663, COG5663, Uncharacterized conserved protein [Function unknown].	9.13522e-07

>NC_008554.1|WP_011698135.1|1570638_1570986_-|hypothetical-protein
MSKLMQIDVRIQAVYGSAGLRGNLPNLSKLLKDHRYDRVLDEEPSLYQMAEVLSRIAKDPAIPEGEKRPVLKMMGRIVEIRDTARELLLARRLDELDKALYRMEDCFKDLEQELD
>NC_008554.1|WP_011698134.1|1569041_1570331_+|adenylosuccinate-synthase
MANVVIVGSQWGDEGKGKIVDLFTEKADYVVRFQGGNNAGHTLVVNGEKHIFHLVPSGILHKGKVCMIGNGVVVDPGVLIREMDRLHEAGIPVTRENLLISRYAHVIMPYHRAMDNARENRKGKTKIGTTGRGIGPCYEDKVARCGVRIHDLSDPKTLGEKIRRNLEEKNFLLERFFGEKPLDAAAMEQEYLAYGERLAPLVDNVSERLQEAVREGRNILFEGAQGTHLDIDHGTYPFVTSSNTVAGNAACGSGIGPTRIDRVLGVVKAYTTRVGGGPFPSELLDETGERMRTRGGEFGATTGRPRRCGWLDMVVVKTAIRLNGLSGLLITKLDVLTGIPKLKIVTSYKCGPRKIEFMPPELEALEACEPVYEEFHGWEEDIGSVRKFTDLPVNTRRYLQALEEMAGVPLMVVSVGPARDETIVLEYPF
>NC_008554.1|WP_011698132.1|1567583_1568432_+|zinc-metalloprotease-HtpX
MGSRFRTTVLLAALTALIIWIGGAVGGSHGMMIAFVLALVMNVGSYWFSDKIVLAMYRAQPLSEADAPQIYRIVRELSASANLPMPRVYLIPESAPNAFATGRNPENAVIAVTEGLWRILTPDEIRGVLAHELAHVKNRDILVSSIAATLAGVVMILARMAQWGALFGGGRSSSDEDSGGGMLGLVVTAILAPIAAMLIQLAISRSREYLADETGAAFSHNPESLARALEKLAMASHQNPMEDASPSTAHLFIVNPLSGRSLANLFSTHPPIEERIRRLRSM
>NC_008554.1|WP_049766306.1|1566945_1567407_+|Hsp20/alpha-crystallin-family-protein
MVRDTMLSKLAEMKRRMDALYAESFKPENEQSADVETAAVDWEPSADITEREDAVRFFIDLPGVLESELTVEVADNRLVVRGKREIPIEDAPASACRCHRERPYGSFRRVFAIPGDCLTESIGAELKAGVLSIEIPRQAPHRGSAHKVEVRSE
>NC_008554.1|WP_011698130.1|1564775_1566521_-|proline--tRNA-ligase
MRYSKYFIHTLFEVPKEAETPSHILLLRGCYIHPVAAGVYSLLPLGHRVAEKIKAILREELNAIEGLEVTMPVLNPAELWKKSSRYYDIGQELFRIKDRKDREFVLAMTHEEVITDIARQFLRSYRHLPVMLYQIQTKIRDEARPRAGLLRVREFFMNDAYSFHPDFADLDAYYPRIFNAYLRIFTRCGLTTVPIEADSGIMGGTGSHEFMLESPNGEDRFVVCTQCDYRANTEKAQGLIPPVKYSGDAPPPMEAVPTPGIKTIADLMRFFDCPEDRLLKTVAYEADGELVLAVIRGDFSVSATKLANHLKAVKVDFAPEKSLSARGLHAGFLSPVGLHGVKIVCDASVTGPAPFVAGGNAPDVHYRNVVCGRDFTPFDAADLAEVRDGDRCTRCAEGILRIRRGIELGHTFKLGTKYTAAESMDATYLDAAGNQQRVVMGCYGIGVERLMASAVEQWHDEGGMSFPYSIAPFQVILCSLGRKPEILEAAQALYERLGAHYDTIYDDRDESPGVKLKDADLLGVPIRVVVSQKLLQKGEVEIKVRRTGVVIVCPRDELLETLERIVADLQPSFEGLPFMPE
>NC_008554.1|WP_011698129.1|1564055_1564559_-|calcium-binding-EF-hand-containing-protein
MSRSIGFLQLAVAMTIIFAAGAAGAQMSGPDRQARFDALDTDYDGRVSHDEFVSDAKARAERLFGRLDTHGDGYFTGDQVDKARKDAAERRGGAPPRGAQPRFQGMDASRDGKVSHDEFMSGSAVQAERRFRRMDVNGDGYLSREEFLGARTQKPKRLDDRSEPPVR
>NC_008554.1|WP_011698128.1|1562618_1564031_+|tRNA-lysidine(34)-synthetase-TilS
MQHPLPHRLSDFVVRHHLISRGDHVLVAVSGGPDSIALLHLLAHQRESLAIGRISVLHFNHRLRGAESDADCVFVRSVAEKMGLPVVCGEEDVRRYRQGRTISMEMAARERRHRFFRRSLDQYSAQRIALGHTSNDQAEEVLLRLLRGVGPSGMEGMRPLGPGGVIRPLLFAGRAEILEYLHDLKIPFREDSSNLEPVCRRNVLRLQVLPLLEKHFHPRLVRTLSRHARLVAEEESWWSDRMRAMWPEICPSETSGRVELDREALRTLHPALQRRVFRHAVERFQGHLMGISTAHVLALCRLAATDASGKEIHLPGGLRAVAEGHRIFLALASEAAGPVAPAAGRLIVPAPGRYDYAGMTIDIRKEVSAKPGSGALPTPVPNAAHMDADAIRWPMTIRSWKPGDRFRPLGLHGTKKLQDFFTDSKIPRSERRRIPLLCDGEKICWVVGRRLDDRVKVTPQTKEIIVAELI
>NC_008554.1|WP_011698127.1|1561698_1562514_+|hypothetical-protein
MKKAESTDRSSGGIAALFDDAERKELFRKYLYFLGWIELLILIICWLYQLGDGARDRFGNVEATFPWRVYFVVAFLVPVAVTFLVGVVIVGFNKYFGDPKDSAPVVPGGATDETDEKSDRIYKLNRMVTLLRQLPFLALLLLLGVAVGFFYKLDVIMSFVGSVGEKSVKVFLISAAILLGVVSIFALILIVLNFQLRKRSMEYQYRADVAERFGLIILDDNTVLNSEGKLLINGKKWKESVPLLTSEPPRSAGAEPEVGGHPPRTIDCETT
>NC_008554.1|WP_011698126.1|1560518_1561424_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MSGSPDLVLETDFPGLKLLNRGKVRDIYDLGDSLLIVATDRISAFDVIMPNPVPDKGRILTRITEFWLRFLSDVTENHLISSDVSRYPEQCRPYERVLAGRSMWVKKARVFPVECIVRGYLAGSGWEDYRKTGQVCGIALPAGLQEAQQLPEPIFTPSTKATLGEHDENISFDAMAAAIGEEMAQGVRDVTIKVYLKASSYARQRGIILADTKFEFGLVEGRLTLVDEVLTPDSSRFWPADRYRVGSSPESFDKQYLRDYLVRSGWKKTDPPPVLPPDVVENTRKRYLEALERLSGHGLEG
>NC_008554.1|WP_083763971.1|1559536_1560535_-|ParB-N-terminal-domain-containing-protein
MDWKADMRGFHSPVELESVDFSERTFAIRRFSPSDALHRSLDRHGILNPPWVLSERAGRFIIVDGFKRLEWARDRRLQSVECMVFPADSDRAALMLNRIEARLFGPSLNAAEKAQIVSKLACHVPAERLPRELGGMQGIVSRPGAVEAWRRAADAGGALLPALGAEEIGERAALEIVKWDEADRDAMIALLKILRCSSSIQLEIVERVDEISRQQGRSRREVLHEGELTRIAADPGANRRQKTQEIREVLRRWRFPRLSARADRFAEELVDASLPGGIEVVPPPSFEGEDWQLRIDFSDPEQLRLRLEAAERFARSPNLVRLMRHDVPGCRK
>NC_008554.1|WP_150109450.1|1571946_1575018_+|formate-dehydrogenase-N-subunit-alpha
MKLTRRDFLKISSAATAGLALSGMGFNLTPVQAYTWELRTKDAKETPTICCYCAVGCGIICHTDKKTGQVIYTEGDADHPINGGSLCAKGASSYQLAQNPKRVTKVLYRAPNSDKWVAKDWKWALQEIAKRVKKSRDASFVEKNAQGQIVNRCMGIASVGSAAMDNEECWIYQAMLRALGLVYIEHQARIUHSATVAALAESYGRGAMTNHWIDLANADCILIMGSNAAENHPISFRWVMKAKDKGAVVINVDPRFTKTSTKSDIYAPLRSGTDIAFLGGMIKHILENKKFFNDYVINYTNASYIVGEKFDFKDGLFSGYNAEKRSYDKSSWAYELDEKGVPKKDLTLQNPRCVFQLLAKHYSRYDLDTVSKVTGTPKDDLTKVYEAYSATGVPDKAGTIMYAMGWCQHSVGVQNIRTMSIIQLLLGNMGIAGGGVNALRGESNVQGSTDQGLLFHILPGYLPTPAASLATLADYNKKNTPVSKDPLSANWWQNRPKYLVSLLKTLYGDAAKPENEFAYGWLPKIDDGKAYSWLDLFDAMYKKEFTGFFSWGQNPACSGANSNKTRQAMANLDWMVVVNLFENETASFWKGPGMNPKKTKTEVFFLPCCAFLEKEGSIANSGRWAQWRYKAQEPAGQSLPDGDIIYELFLEIRKLYQKPGGKFPDPILKLQWNYAANHKFDPHLVAKEINGYWLKDTTVGDKTFKKGDLVPAFAMLKDDGSTSCGNWIYCQSYNQDGNNMARRDKTDDSGIGLYPKWAWAWPVNRRIIYNRASVDPAGKPWNPKKAVIEFVGEVKDGKYTTQKWKGDVPDGPWYPLKNPDGSAREDGKLAFIMKPDGYASIYGPGLADGPFPEHYEPLECPVEKNLFSSRITNPVAAVFGTEKDIIKSCDPKFPFVGTTYRVTEHWQTGVLTRWLPWLLEAEPQLFVEMSEELAKLKEIKNGDKVIVESPRGSVEAVAIVTKRWKPFQIQDQEVHQVGLPWHFGWVWPPEGGDSANLLTPSVGDPNTRIPESKAFMVNVRKKG
>NC_008554.1|WP_011698138.1|1575021_1575753_+|4Fe-4S-dicluster-domain-containing-protein
MAGKSFFIDTTRCTACRGCQIACKNWNRNEGSLTKNTGSHQNPPDFDANTFKLVRFSEVENEGKVAWYFFADQCRHCLVPPCKDVIEGTVPDSVIQDEATGAVVYTEKTAEAPLDDVRESCPYDVPRKKDKGPFVKCTMCIDRVSNGLVPACVKICPTGAMNFGDRDEILAMAKDRVEKLKPRYPKAQLLDANEVRVIFLVVDDPRKYHKKAVASLSPGIQRPAGKSTLAGPARRVLKTVLGV
>NC_008554.1|WP_011698139.1|1575909_1576812_+|formate-dehydrogenase-accessory-protein-FdhE
MDNQHNPEKDRIGQAFALARAEKPAYADLYPFLETLFLLRAGGKSAARPERFELSAEHARARWEGSFPLLRRWEFPLDTEAAESLLEMIAGSLPEDNVQLKGAHESLSRALANHPEQRTAIWRSFLQHEMEPWEEWLDVAGVDTASLLFLARNCLRPSVELVAEDLLQRFPIPKEWLKGYCPVCGSLPSLLFLEKDGQRNGYCSWCGTSWGLNRLQCCYCDNRFHESLGYLYAEAETHYHIQYCNLCKYYFKLVLTGELLYPPYLPLEEWTTLHLDLLAQRAGFKQPPSPSPVVYGDAPA
>NC_008554.1|WP_011698141.1|1577229_1579134_+|GNAT-family-N-acetyltransferase
MVFDEHWKTHYRERLDTAKSTLEAAIKDGNRIFIASACGEPQHLVRALVELLPRYRDLELVQNLSVGELPEDWSELKDHCRLKTFFVGPRVRKAVNEGFADYIPTYFSAIPGLIREDNLWAVDICLIQVSPPDEHGFCSLGIAVEITKSAADAAKIVIAQVNPRMPRVLGDSFLHVSQIDHFVEYEEPLIEVVFRERSAITERIAKYVSLLVEDGSTLQVGVGRIVNSVLTYLEDKKDLGVHTEILTDAHLHLVKKGVITGLRKEVHPGRIVTSACTGSADLYSFVHNNPEVEIYPIEYVNDRRLISRHDQMVAINSALEIDLSGQVCSDSIGHTIHSGIGGFVDFTHGAATARHGKSIIVLPSTSTDGRRSRIVSHLASGAGVVSSRSMVRYVVTEFGIAYLHGKTIRERALALINIAHPKFRERLLGEAKRLRYVYDDQILPPIYEPLYPGQWETHRLFPGDRNIFFRPIKPTDERGVQEFFYSLPDQDIYYRFLSAMKVFPHRNTQGMCNIDYEHEMAIVGVTGEIGSETIIGLGRYILDQKTNIAEVDFAVAAEWQRIGIGTFLLHYLCEIAGSKGITGFTAYVLAANRKMLSVFHKVGYFIHTTLEDGVYEISFRFDEPASTCPVDCPP
>NC_008554.1|WP_011698142.1|1579130_1579745_+|hypothetical-protein
MTGHSEIRFSPSELAFDIDGVVADTMEVFVRLAHGRYGLTYLTKEHLGCYNLYQCLDLEKEVIDDLICLTLDDEHTLQIPPVSDAPEVLTELSRHGPLRFVTARIWPESIIRWLHMTLSEVSANDIKVVATGTPEAKLKVLKDLGVRCFVEDRLETCRMLANEGIQPLVFDQPWNRTFLDDEFPRVRNWSQLRQWVLPRNGELL
>NC_008554.1|WP_011698143.1|1580040_1580703_+|septum-site-determining-protein-MinC
MSKNESLPIQVKAGREGFTLVIHQTAPFESILEYMTQRMSESQDFFGQSEISLDLRSRPLRTDEIAALCDLLTKSSKLKLVEVRLSDEVRFSLDRSRAAKEAAPAKRRSVPKDVEPVIVRNTCRSGARVVSATDCVVLGDVNPGAEIIAAGDIIVFGNLRGLAHAGATGDRSARIWALSIEPNQLRIADLVAVPPRGNKPVPKRYEIAEIRENQIAVSTM
>NC_008554.1|WP_011698144.1|1580774_1581566_+|septum-site-determining-protein-MinD
MAGKVIVVTSGKGGVGKTTTVANIGTTLAKKKHSVVMIDADIGLRNLDVVMGLENRIVYNLVDIIEGKCRKQQAMIRDRKLANLYIIPAAQTREKNAVQPEQMKSLCAELAEEFDYVLIDCPAGIEQGFRNAVAGAQTALIVTTPEVSAIRDADRVIGLLEAGLLRDIHLIVNRLNQRMVKKGDMMSTADIVSLLAVPLLGVVPESEEVVISTNRGVPLVHDRGSRAGIAFQKIAARLNGEQIPIEEENGNGFISRMKRFIWS
>NC_008554.1|WP_011698145.1|1581582_1581861_+|cell-division-topological-specificity-factor-MinE
MLKAIRRFFGEKASGQVARRRMQVVLMHDRMDLTPDIMEALRNDILAVISRYMEIDSRSIRVDLEQGKEYMALVSNIQIKRVYRKAAPDIRS
>NC_008554.1|WP_041440071.1|1582150_1582390_+|hypothetical-protein
MALRVFLAATLRRYVPGYDGAVGCALEIRRGSCVRDVAKAFGVPEDEVKLILVNGIGSNWDTVLEGDERVALFPPVGGG
>NC_008554.1|WP_011698147.1|1582761_1582989_-|hypothetical-protein
MAKEAKTVYSFPKNPLEEVRASLTVFKGKDYVDLRIYYKGDDGEYHPSKKGLTLSLDLFSELEESVRKLAEAIGE

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Crispr_ID: NC_008554_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_10

1684126-1689168

TypeIII

Consensus_repeat	Method
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CRISPRCasFinder
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CRT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	PILER-CR

69 spacers

cas2,cas1,PrimPol,csx1,csx20,cas6,cas10,csm2gr11,csm3gr7

The CRISPR arrays of NC_008554_10

>merge|NC_008554|10|1684126-1689168|CRISPRCasFinder,CRT,PILER-CR
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCTTTCGCGTTCAGTCTCTGTACTTTCATCGTCAGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCGCCTTCTTCCTGGCCGCTTCCCTCAGTCTCTTCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCGTCGCCTTCTTCCTGGCCGCTTCCCTCAGTCTCTTCAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGCGTACTACTGATTCATGTTCCAGAAAAAAAATTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCTTCATCCGGTAATCTGACCATCAACCCTTTCATCTTGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGCCTTTCCCCGAAAAAACCGTCGCGTTCCATTTTTCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATGGTTCCTTCTCCTTCTTGGTTGTGCCCCTTTCGGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCCTGCCACTCCTCGACCTCTGCCTCCAGCTTCATACAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGGATGTATGCCGCGCTATTCTCCAACGTCTGTGGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCTTGGTTGTGCCCCTTTCGGGGCTCTGTAGTCATCGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCAACCCAGGAAACCACTATCCCGGCTGGATTTTCCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCGGTCATGGCTCGTTCGTTTGCTCCGATTTCGTTGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGGGTTGTGTGCCTTTCTCCGAAAAATCCGTCGCGTTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTTTCTTCTCCTTTGGTTGTGCCCCTTCCCGGGGCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGTCTCAAGCCGATCGGGGCTCTGTTGTCATCGCCTCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGGGATTTCCCGTCCCATCCGAGGCGCTTGGCCTCGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCACTACGACCTCACCAGTTGTGAGTGTCACAACTGGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATGTCCCGGTCGAGCATCTCGATGCTCTCCGGGTACTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCCTTTCCATAAAATCTGTCCAAAATCTCGTCCATGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCCCTTCTCATCGGAGACCCCTTTCTGCCCCTTTCGGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCATTGCTGACGGGCAGGGGGAAATCAGGAGAGGTTGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCATCGCGTCACCCTGGAATCCGAGGTCAACCCGGTAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTTCGCCTAGCCCGCCTCGGGTGCCTCCGGGGCGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCACATGGCGGCTCAAGGCATACGATATCTGGACCGGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGCGTTTGCTGGTCGCTTGACGAATTGCAGCGAGTACGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACACTCATGGTCTCTCCTTTCGGTTGTGCCCATCACTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTAGGGGTGATTTTTGGCATTATTTCCTCCCTCCTGCAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAGGCGTCCATGAGCAACTCTGCTCCGGCGTGCTTCGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGTTGCCCCGCTCCCACCCGAGACGGGATGTCCCGTCCCATGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGCAATCACATGTCTGGCACTCGGATCCCACTCTGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAACTGGTCGGTGTATTTACTCATGGTCTCTCCTTTCGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGCCTCTTGGATAGTCTTTCTCATTTCCTTCAAGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGACGATACGACGGACGCTATCTGCGGTTCCGTGGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATCCGCGAATTCGGCAATCGTCTGCCAGAAGAATTCCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAACCATGCTCCGGTGGCACACCATACAGGTGTGCATTTGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATTAATGACATCAATGAGAGCACTCAATTGATTTTCAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATGATCTTGATAACTGCGTGTACTCAATCGAAGTGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTATCCGTACAAAAAACGAAATGAGACCTATTCTCCTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTCCGTGTTCGGGGCACGCGGCGTGCCAGTGGACGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCAGCGACGCGCCGTGTCGGCGAGCAATCTTGTCCGCCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGGGACACTCAACGCGCCTAGTGGTGATCGTCATGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGGATTTCCTCGATCACGTCCGTTGAGCGGTCTATGGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCATTTGTTTTCCGAAGGCGGTCTTCAATCCGCCTTCGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTTCCGACGAGACCCAATTCTCCGGGTTAAACCGAACGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATGCAGCATCAAATGATCTTGATAGTTGTGTGTACTCTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAAGATCGGGAACAATCCATCGGTCGACCGGCCTTGTTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATACTGCTCCCGATCTGGTTAGCTGATCCTGGTCAGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAGGATTTTTCCGAAGTTCGTGAGGCTCACGGCCTCGTGAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACCCCGGCTAACCCCTCGGAAGGACATGATCTGTGTGGCTGTCCTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACACTCCTGCGGTTGCACATGGTCTATTGTCAACTGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAACCCCTCGTAGACGTACAAATCCACGAGGGCGCGAGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGTGCCCCAGATTCACCGTCGCAAACCAGTGCCGTCTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATGACGGATTCGTTTCTGACTGTGAAAGAACGCATATTTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCCAGGACGGATTCGTTTCTGACTGTGAAGGCTTGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGATTGATGTCATCAAGATCACCATCATAATTAATAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACAGAGAGTCGAGCCTCGTCAAGAACCGATCGGCATCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACATAATTCCGGCCGCTCTCAGGGCGGCCATGACGTCCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCCCAACGCTCGGCAGGGCTCGACTCGTTCGAGAGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTGGCCTGTTTGTGCCCCGATCCGGTGTAATAATCTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTCCATGGCATCCCGAACGCGTTCTTTATCCCAATAAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGATCCGAAAAGAGAACGGGTCCAAAGTCTTAAAGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAGGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTTGATTTTTTCCTGATCTACTTTAAAGGCATTGGCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTCTGCAATTGAGATTTGGCAACACCTTTAATCTTGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGCGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACGCGGCGTAGGCCCGCTCGAAGTTGGCAATCGCTTTGACGGAGACAGAGCCCCGATTTGAGGGGATTGAGACTTCCCGGTAATCCGATGGGGCTGGCGCAGGATCACGGGACGGAGACAGAGTCCCGATTTGAGAGGACCGTAAG

>NC_008554|10|10|1684126-1689168|CRISPRCasFinder
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCTTTCGCGTTCAGTCTCTGTACTTTCATCGTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCGCCTTCTTCCTGGCCGCTTCCCTCAGTCTCTTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CGTCGCCTTCTTCCTGGCCGCTTCCCTCAGTCTCTTCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCGTACTACTGATTCATGTTCCAGAAAAAAAATT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CTTCATCCGGTAATCTGACCATCAACCCTTTCATCTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCCTTTCCCCGAAAAAACCGTCGCGTTCCATTTTTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGGTTCCTTCTCCTTCTTGGTTGTGCCCCTTTCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CCTGCCACTCCTCGACCTCTGCCTCCAGCTTCATACA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGATGTATGCCGCGCTATTCTCCAACGTCTGTGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CTTGGTTGTGCCCCTTTCGGGGCTCTGTAGTCATCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCAACCCAGGAAACCACTATCCCGGCTGGATTTTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CGGTCATGGCTCGTTCGTTTGCTCCGATTTCGTTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGGTTGTGTGCCTTTCTCCGAAAAATCCGTCGCGTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTTCTTCTCCTTTGGTTGTGCCCCTTCCCGGGGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GTCTCAAGCCGATCGGGGCTCTGTTGTCATCGCCTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GGGATTTCCCGTCCCATCCGAGGCGCTTGGCCTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CACTACGACCTCACCAGTTGTGAGTGTCACAACTGGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGTCCCGGTCGAGCATCTCGATGCTCTCCGGGTACT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCTTTCCATAAAATCTGTCCAAAATCTCGTCCATG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCCTTCTCATCGGAGACCCCTTTCTGCCCCTTTCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CATTGCTGACGGGCAGGGGGAAATCAGGAGAGGTTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCATCGCGTCACCCTGGAATCCGAGGTCAACCCGGTA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTCGCCTAGCCCGCCTCGGGTGCCTCCGGGGCGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CACATGGCGGCTCAAGGCATACGATATCTGGACCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCGTTTGCTGGTCGCTTGACGAATTGCAGCGAGTAC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ACTCATGGTCTCTCCTTTCGGTTGTGCCCATCACT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TAGGGGTGATTTTTGGCATTATTTCCTCCCTCCTGCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGGCGTCCATGAGCAACTCTGCTCCGGCGTGCTTCGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGTTGCCCCGCTCCCACCCGAGACGGGATGTCCCGTCCCAT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCAATCACATGTCTGGCACTCGGATCCCACTCTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACTGGTCGGTGTATTTACTCATGGTCTCTCCTTTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGCCTCTTGGATAGTCTTTCTCATTTCCTTCAAGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGACGATACGACGGACGCTATCTGCGGTTCCGTGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATCCGCGAATTCGGCAATCGTCTGCCAGAAGAATTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACCATGCTCCGGTGGCACACCATACAGGTGTGCATTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATTAATGACATCAATGAGAGCACTCAATTGATTTTCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGATCTTGATAACTGCGTGTACTCAATCGAAGTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTATCCGTACAAAAAACGAAATGAGACCTATTCTCCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCCGTGTTCGGGGCACGCGGCGTGCCAGTGGACGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CAGCGACGCGCCGTGTCGGCGAGCAATCTTGTCCGCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGGACACTCAACGCGCCTAGTGGTGATCGTCATG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GGATTTCCTCGATCACGTCCGTTGAGCGGTCTATGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CATTTGTTTTCCGAAGGCGGTCTTCAATCCGCCTTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTCCGACGAGACCCAATTCTCCGGGTTAAACCGAAC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGCAGCATCAAATGATCTTGATAGTTGTGTGTACTCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AAGATCGGGAACAATCCATCGGTCGACCGGCCTTGTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATACTGCTCCCGATCTGGTTAGCTGATCCTGGTCAGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGGATTTTTCCGAAGTTCGTGAGGCTCACGGCCTCGTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CCCGGCTAACCCCTCGGAAGGACATGATCTGTGTGGCTGTCCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ACTCCTGCGGTTGCACATGGTCTATTGTCAACTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACCCCTCGTAGACGTACAAATCCACGAGGGCGCGAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GTGCCCCAGATTCACCGTCGCAAACCAGTGCCGTCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGACGGATTCGTTTCTGACTGTGAAAGAACGCATATTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCAGGACGGATTCGTTTCTGACTGTGAAGGCTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGATTGATGTCATCAAGATCACCATCATAATTAATA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGAGAGTCGAGCCTCGTCAAGAACCGATCGGCATC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATAATTCCGGCCGCTCTCAGGGCGGCCATGACGTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCCAACGCTCGGCAGGGCTCGACTCGTTCGAGAGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGCCTGTTTGTGCCCCGATCCGGTGTAATAATCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCATGGCATCCCGAACGCGTTCTTTATCCCAATAA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGATCCGAAAAGAGAACGGGTCCAAAGTCTTAAA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTGATTTTTTCCTGATCTACTTTAAAGGCATTGGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCTGCAATTGAGATTTGGCAACACCTTTAATCTTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGGCGTAGGCCCGCTCGAAGTTGGCAATCGCTTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCCCGGTAATCCGATGGGGCTGGCGCAGGATCACGG
GACGGAGACAGAGTCCCGATTTGAGAGGACCGTAAG

>NC_008554|10|1|1684126-1689168|CRT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCTTTCGCGTTCAGTCTCTGTACTTTCATCGTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCGCCTTCTTCCTGGCCGCTTCCCTCAGTCTCTTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CGTCGCCTTCTTCCTGGCCGCTTCCCTCAGTCTCTTCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCGTACTACTGATTCATGTTCCAGAAAAAAAATT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CTTCATCCGGTAATCTGACCATCAACCCTTTCATCTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCCTTTCCCCGAAAAAACCGTCGCGTTCCATTTTTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGGTTCCTTCTCCTTCTTGGTTGTGCCCCTTTCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CCTGCCACTCCTCGACCTCTGCCTCCAGCTTCATACA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGATGTATGCCGCGCTATTCTCCAACGTCTGTGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CTTGGTTGTGCCCCTTTCGGGGCTCTGTAGTCATCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCAACCCAGGAAACCACTATCCCGGCTGGATTTTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CGGTCATGGCTCGTTCGTTTGCTCCGATTTCGTTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGGTTGTGTGCCTTTCTCCGAAAAATCCGTCGCGTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTTCTTCTCCTTTGGTTGTGCCCCTTCCCGGGGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GTCTCAAGCCGATCGGGGCTCTGTTGTCATCGCCTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GGGATTTCCCGTCCCATCCGAGGCGCTTGGCCTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CACTACGACCTCACCAGTTGTGAGTGTCACAACTGGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGTCCCGGTCGAGCATCTCGATGCTCTCCGGGTACT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCTTTCCATAAAATCTGTCCAAAATCTCGTCCATG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCCTTCTCATCGGAGACCCCTTTCTGCCCCTTTCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CATTGCTGACGGGCAGGGGGAAATCAGGAGAGGTTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCATCGCGTCACCCTGGAATCCGAGGTCAACCCGGTA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTCGCCTAGCCCGCCTCGGGTGCCTCCGGGGCGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CACATGGCGGCTCAAGGCATACGATATCTGGACCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCGTTTGCTGGTCGCTTGACGAATTGCAGCGAGTAC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ACTCATGGTCTCTCCTTTCGGTTGTGCCCATCACT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TAGGGGTGATTTTTGGCATTATTTCCTCCCTCCTGCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGGCGTCCATGAGCAACTCTGCTCCGGCGTGCTTCGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGTTGCCCCGCTCCCACCCGAGACGGGATGTCCCGTCCCAT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCAATCACATGTCTGGCACTCGGATCCCACTCTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACTGGTCGGTGTATTTACTCATGGTCTCTCCTTTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGCCTCTTGGATAGTCTTTCTCATTTCCTTCAAGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGACGATACGACGGACGCTATCTGCGGTTCCGTGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATCCGCGAATTCGGCAATCGTCTGCCAGAAGAATTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACCATGCTCCGGTGGCACACCATACAGGTGTGCATTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATTAATGACATCAATGAGAGCACTCAATTGATTTTCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGATCTTGATAACTGCGTGTACTCAATCGAAGTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTATCCGTACAAAAAACGAAATGAGACCTATTCTCCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCCGTGTTCGGGGCACGCGGCGTGCCAGTGGACGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CAGCGACGCGCCGTGTCGGCGAGCAATCTTGTCCGCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGGACACTCAACGCGCCTAGTGGTGATCGTCATG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GGATTTCCTCGATCACGTCCGTTGAGCGGTCTATGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CATTTGTTTTCCGAAGGCGGTCTTCAATCCGCCTTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTCCGACGAGACCCAATTCTCCGGGTTAAACCGAAC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGCAGCATCAAATGATCTTGATAGTTGTGTGTACTCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AAGATCGGGAACAATCCATCGGTCGACCGGCCTTGTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATACTGCTCCCGATCTGGTTAGCTGATCCTGGTCAGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGGATTTTTCCGAAGTTCGTGAGGCTCACGGCCTCGTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CCCGGCTAACCCCTCGGAAGGACATGATCTGTGTGGCTGTCCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ACTCCTGCGGTTGCACATGGTCTATTGTCAACTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACCCCTCGTAGACGTACAAATCCACGAGGGCGCGAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GTGCCCCAGATTCACCGTCGCAAACCAGTGCCGTCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGACGGATTCGTTTCTGACTGTGAAAGAACGCATATTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCAGGACGGATTCGTTTCTGACTGTGAAGGCTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGATTGATGTCATCAAGATCACCATCATAATTAATA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGAGAGTCGAGCCTCGTCAAGAACCGATCGGCATC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATAATTCCGGCCGCTCTCAGGGCGGCCATGACGTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCCAACGCTCGGCAGGGCTCGACTCGTTCGAGAGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGCCTGTTTGTGCCCCGATCCGGTGTAATAATCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCATGGCATCCCGAACGCGTTCTTTATCCCAATAA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGATCCGAAAAGAGAACGGGTCCAAAGTCTTAAA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTGATTTTTTCCTGATCTACTTTAAAGGCATTGGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCTGCAATTGAGATTTGGCAACACCTTTAATCTTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGGCGTAGGCCCGCTCGAAGTTGGCAATCGCTTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCCCGGTAATCCGATGGGGCTGGCGCAGGATCACGG
GACGGAGACAGAGTCCCGATTTGAGAGGACCGTAAG

>NC_008554|10|1|1684342-1689095|PILER-CR
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCGTACTACTGATTCATGTTCCAGAAAAAAAATT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CTTCATCCGGTAATCTGACCATCAACCCTTTCATCTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCCTTTCCCCGAAAAAACCGTCGCGTTCCATTTTTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGGTTCCTTCTCCTTCTTGGTTGTGCCCCTTTCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CCTGCCACTCCTCGACCTCTGCCTCCAGCTTCATACA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGATGTATGCCGCGCTATTCTCCAACGTCTGTGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CTTGGTTGTGCCCCTTTCGGGGCTCTGTAGTCATCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCAACCCAGGAAACCACTATCCCGGCTGGATTTTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CGGTCATGGCTCGTTCGTTTGCTCCGATTTCGTTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGGTTGTGTGCCTTTCTCCGAAAAATCCGTCGCGTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTTCTTCTCCTTTGGTTGTGCCCCTTCCCGGGGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GTCTCAAGCCGATCGGGGCTCTGTTGTCATCGCCTC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GGGATTTCCCGTCCCATCCGAGGCGCTTGGCCTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CACTACGACCTCACCAGTTGTGAGTGTCACAACTGGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGTCCCGGTCGAGCATCTCGATGCTCTCCGGGTACT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCTTTCCATAAAATCTGTCCAAAATCTCGTCCATG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCCTTCTCATCGGAGACCCCTTTCTGCCCCTTTCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CATTGCTGACGGGCAGGGGGAAATCAGGAGAGGTTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCATCGCGTCACCCTGGAATCCGAGGTCAACCCGGTA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTCGCCTAGCCCGCCTCGGGTGCCTCCGGGGCGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CACATGGCGGCTCAAGGCATACGATATCTGGACCGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCGTTTGCTGGTCGCTTGACGAATTGCAGCGAGTAC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ACTCATGGTCTCTCCTTTCGGTTGTGCCCATCACT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TAGGGGTGATTTTTGGCATTATTTCCTCCCTCCTGCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGGCGTCCATGAGCAACTCTGCTCCGGCGTGCTTCGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGTTGCCCCGCTCCCACCCGAGACGGGATGTCCCGTCCCAT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCAATCACATGTCTGGCACTCGGATCCCACTCTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACTGGTCGGTGTATTTACTCATGGTCTCTCCTTTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGCCTCTTGGATAGTCTTTCTCATTTCCTTCAAGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGACGATACGACGGACGCTATCTGCGGTTCCGTGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATCCGCGAATTCGGCAATCGTCTGCCAGAAGAATTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACCATGCTCCGGTGGCACACCATACAGGTGTGCATTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATTAATGACATCAATGAGAGCACTCAATTGATTTTCA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGATCTTGATAACTGCGTGTACTCAATCGAAGTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTATCCGTACAAAAAACGAAATGAGACCTATTCTCCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCCGTGTTCGGGGCACGCGGCGTGCCAGTGGACGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CAGCGACGCGCCGTGTCGGCGAGCAATCTTGTCCGCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGGACACTCAACGCGCCTAGTGGTGATCGTCATG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GGATTTCCTCGATCACGTCCGTTGAGCGGTCTATGG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CATTTGTTTTCCGAAGGCGGTCTTCAATCCGCCTTCG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTCCGACGAGACCCAATTCTCCGGGTTAAACCGAAC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGCAGCATCAAATGATCTTGATAGTTGTGTGTACTCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AAGATCGGGAACAATCCATCGGTCGACCGGCCTTGTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATACTGCTCCCGATCTGGTTAGCTGATCCTGGTCAGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGGATTTTTCCGAAGTTCGTGAGGCTCACGGCCTCGTGA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	CCCGGCTAACCCCTCGGAAGGACATGATCTGTGTGGCTGTCCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ACTCCTGCGGTTGCACATGGTCTATTGTCAACTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AACCCCTCGTAGACGTACAAATCCACGAGGGCGCGAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GTGCCCCAGATTCACCGTCGCAAACCAGTGCCGTCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATGACGGATTCGTTTCTGACTGTGAAAGAACGCATATTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCAGGACGGATTCGTTTCTGACTGTGAAGGCTTG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGATTGATGTCATCAAGATCACCATCATAATTAATA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	AGAGAGTCGAGCCTCGTCAAGAACCGATCGGCATC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	ATAATTCCGGCCGCTCTCAGGGCGGCCATGACGTCC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCCAACGCTCGGCAGGGCTCGACTCGTTCGAGAGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTGGCCTGTTTGTGCCCCGATCCGGTGTAATAATCT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TCCATGGCATCCCGAACGCGTTCTTTATCCCAATAA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGATCCGAAAAGAGAACGGGTCCAAAGTCTTAAA
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TGCTTCGTCATGCTCGACCTCCTTCGGGGTGTTCAG
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTTGATTTTTTCCTGATCTACTTTAAAGGCATTGGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	TTCTGCAATTGAGATTTGGCAACACCTTTAATCTTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGCGAATAGCCTTGTCCCAATCGAACTGGTTCTTGC
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC	GCGGCGTAGGCCCGCTCGAAGTTGGCAATCGCTTT
GACGGAGACAGAGCCCCGATTTGAGGGGATTGAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_041440094.1\|1677238_1678585_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|187863
NC_008554.1\|WP_011698228.1\|1701059_1702466_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_008554.1\|WP_011698224.1\|1698282_1698603_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376116
NC_008554.1\|WP_011698223.1\|1695999_1697796_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_008554.1\|WP_167321391.1\|1692593_1692644_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698217.1\|1682180_1683233_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_008554.1\|WP_011698211.1\|1672746_1675293_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NC_008554.1\|WP_011698218.1\|1683280_1683559_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_008554.1\|WP_011698209.1\|1671476_1672202_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NC_008554.1\|WP_153307204.1\|1699769_1699928_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698215.1\|1678883_1680341_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|223533
NC_008554.1\|WP_011698225.1\|1698893_1699715_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273922
NC_008554.1\|WP_011698227.1\|1700426_1700843_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698219.1\|1689481_1691836_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NC_008554.1\|WP_011698213.1\|1676856_1677249_+\|hypothetical-protein	csx20	xls002255_csx20_CAS-I:CAS-III	unknown
NC_008554.1\|WP_011698221.1\|1692761_1694333_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235730
NC_008554.1\|WP_011698216.1\|1680405_1682031_+\|hypothetical-protein	PrimPol	COG4951_PrimPol_CAS-I:CAS-III	gnl\|CDD\|227287
NC_008554.1\|WP_011698210.1\|1672216_1672729_-\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NC_008554.1\|WP_049766313.1\|1675312_1676344_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	mkCas0066_cas6_CAS-I:CAS-III	gnl\|CDD\|337605
NC_008554.1\|WP_011698222.1\|1694891_1696007_-\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|223708

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_041440094.1\|1677238_1678585_+\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|187863	cd09732, Csx1_III-U, CRISPR/Cas system-associated protein Csx1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; Some proteins could have an additional fusion with RecB-family nuclease domain; Core domain appears to have a Rossmann-like fold; loosely associated with CRISPR/Cas systems; also known as TM1812 family.	2.14926e-75
NC_008554.1\|WP_011698228.1\|1701059_1702466_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_008554.1\|WP_011698224.1\|1698282_1698603_+\|hypothetical-protein	gnl\|CDD\|376116	pfam18692, DUF5640, Family of unknown function (DUF5640). This domain is found in proteins of unknown function. It has composed of eight antiparallel beta strands and carries a G-X-W motif in the N-terminal region. The conserved glycine-X-tryptophan (G-X-W) motif is characteristic for the lipocalin family.	8.04647e-06
NC_008554.1\|WP_011698223.1\|1695999_1697796_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_008554.1\|WP_011698217.1\|1682180_1683233_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	2.66769e-104
NC_008554.1\|WP_011698210.1\|1672216_1672729_-\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	5.35469e-31
NC_008554.1\|WP_011698211.1\|1672746_1675293_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	9.44941e-115
NC_008554.1\|WP_011698218.1\|1683280_1683559_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.06401e-31
NC_008554.1\|WP_011698209.1\|1671476_1672202_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	5.23417e-79
NC_008554.1\|WP_011698215.1\|1678883_1680341_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|223533	COG0457, NrfG, FOG: TPR repeat [General function prediction only].	3.54144e-05
NC_008554.1\|WP_011698225.1\|1698893_1699715_-\|hypothetical-protein	gnl\|CDD\|273922	TIGR02001, gcw_chp, conserved hypothetical protein, proteobacterial. This model represents a conserved hypothetical protein about 240 residues in length found so far in Proteobacteria including Shewanella oneidensis, Ralstonia solanacearum, and Colwellia psychrerythraea, usually as part of a paralogous family. The function is unknown.	2.911e-05
NC_008554.1\|WP_011698216.1\|1680405_1682031_+\|hypothetical-protein	gnl\|CDD\|227287	COG4951, COG4951, Uncharacterized protein conserved in bacteria [Function unknown].	2.74915e-21
NC_008554.1\|WP_011698219.1\|1689481_1691836_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	2.82209e-11
NC_008554.1\|WP_011698221.1\|1692761_1694333_-\|AMP-binding-protein	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	1.33801e-140
NC_008554.1\|WP_049766313.1\|1675312_1676344_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|337605	pfam10040, CRISPR_Cas6, CRISPR-associated endoribonuclease Cas6. Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes.	2.17983e-08
NC_008554.1\|WP_011698222.1\|1694891_1696007_-\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|223708	COG0635, HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism].	1.73715e-121

>NC_008554.1|WP_011698218.1|1683280_1683559_+|CRISPR-associated-endonuclease-Cas2
MFYVVSYDISDDRVRYRVAKVLKAYGVRVQKSVFECPDLTEKRFLKMKDRLEALIDFTTDSVRYYRQCRGCLAQCEVSGAGELPATTKFSVV
>NC_008554.1|WP_011698217.1|1682180_1683233_+|CRISPR-associated-endonuclease-Cas1
MERTYILEQGAYLRKAGNHLVVTKNREIIAEIPLEGLSQLTLVGFSSLSGAVLEVLIRHRIETVLLSPRGQFRARLMVDEHKHVQRRQGQYVKLSGADFALRTTQSIVRGKLRNTARFLALRGSRYGSEALHRAAAQIKGLSALVDRQKDMDLLRGIEGHAANLYFEVFPLLVRVPGFEFNGRNRRPPLDPLNALLSFVYTLLTQEVLTAIKVVGLDPYLGCLHAVDYGRPSLACDLVEEWRTFLGDRLVLALVNRRVIGLDDFVYRPTPCADAVDEEELKHRRPVEMKPKIARAFIEAYEKWMASRILDPGSRERTDYRGLIQRQVWKFCHYLVGDRDSYEPFIWSEVS
>NC_008554.1|WP_011698216.1|1680405_1682031_+|hypothetical-protein
MNAETSPLPKKTGSPDFALLLQQIEKRLLTGSQTEQAVQILGRESIWKTLPPDQALRWARLAQAAGLPDLSLQVLSWVTQSEPGCVEAWQQRVDLLETLGRKQAGPEAAACAVRSENADASGPSPGTPSREDGAPWEEVVETPFTSMRSREAALARYLDLFSGREDCFARQWSDRKAGTQGYIPVRRPMTSEDALEHIGGHRTYGIYLLRRDSHVKVAVVDADLASRLRAGPVTSRDKELVSREKNYLLGRLPEIGREKGLPCLVEFSGGKGFHFWYLFEEPVPATEARQVLQGLVKRIAPDLSCFNLEVFPKQDRLAGKGLGNLVKLPLGIHRVTGKPSFFLHIPDRSPWAQLEALSKVNSIGREPFLAASSSREAGEVVVHPREEMWAKEVPELAFLVDRCTALAQIVTNCRQSRSLSVREEKVLLGTIGFLPRAKTLLHHLFRNLPEYNPHLVDYRLSRVRGSPLGCKRIHGLLDLACDQCTFPDGSAYPHPLLHWPQWKQGAEEQKGERVGNLRDALDRLQEAIGVVERFLGDGANS
>NC_008554.1|WP_011698215.1|1678883_1680341_+|tetratricopeptide-repeat-protein
METTGAKILHHPANIQNSEQATHDGEPVREIPPDPNASSPGTPSVEQTAEAASSEADLLTSLAALGVNEERLKAERRRALGEISALRAENRWEDILSLFHPVEEKNPELLAAGRATAIRGEVAFALGHLGRFDEAIALYHLCVEEEPDNFHHHSGLAYTAYDSLYAARGRQIVLHPEERKARIELAHRHFAVAQSLRPNRVTNYYRQGMLYKSIQGKKEEALPLFAAAVRNWEAYSAEEMKARHQERKNYVKALYQLASCELDAGKPSRALETLNRCLLEDEESGFFSTVHKYFALGKVRFELGDMEASVQALSFAASQAVPEEDDYVFELLARVHLCRGNGDKAWEAVNRVPLKRRRPYFRWTEAEVLIARGEWERARKVLAEAAERDRRGRHKALLRLARLEFRLCRYDQCLKWAKDADNFFRNQFQNPCGDGLFWQAAALLRLGRLDEAENAARKLAKYMPRHPHLGRLRDLIAKATAAGPA
>NC_008554.1|WP_041440094.1|1677238_1678585_+|TIGR02221-family-CRISPR-associated-protein
MEDKNMARVYISFLGTNDYVECRYLDEFDTPEPVRFVQEATIGTICRGWGPGDRITIFTTTDAEKKNWEDNGHYDKDNKRYKECKGLKRCLEELKLTAPFANVHIPDGHSTEEMWDIFQKVFDSLNERDEVVFDITHALRSIPLLAIVVLHYAKVLKRVSLKGIYYGAFEALGSIADVRARPVEERRAPVLDLTDLDKLMDWTMATDRFLQGGDARSAAALAKAEAERELKKTRGKDEAAKAIRSLGCGLEDFSKMLYTCRGREISKASTELKKRAKECRNLKLPKPFRPLFEMIEKRLEAFKGDSLLDGLAAVRWCVDHNLVQQGFTILEEIVFSHTLSGVGLDASDTRLRYVASQAYTIVSRNLDDNPVEWESPARGEEEYTRRMIDFIRGHEDLRSAVATLRARRNDLNHAGFIEKQVSLQKAGDFAEDLERLLGRIEAALTSDF
>NC_008554.1|WP_011698213.1|1676856_1677249_+|hypothetical-protein
MPHSLIVLFNHRLTPEQELDARRNLGVSTVVQPPAAISERWANVPPDLPEIDGYLAPVKHWLETNASPGDQVLIQGDFGATYIMVNFIRGRGLTAVYSTSRREAAEEVQPDGSIKLTHVFRHQRFRKYGG
>NC_008554.1|WP_049766313.1|1675312_1676344_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MEQHKRAEKITKEQTDFLEPMRAFRCLRLKVEAKATGHILLPPYLGSTLRGAFGMALLRSACALRRQKCPTCLLRARCIYSYTFETSPMNGSEADRRYGTAPHPFVLNLETGREGVQEAGSTFHFGMTLVGRAIDFLPYFVFAFQRMGELGIGKGRGTFEVVRVWSLGSRDDPQEILYENEVLRMPGEVPGLDHALALSGSLSSRKVRLRFVTPLRLVYEGELCTDPPRFHVLARNLLRRLNNLVAFHCEGNEGLCVGPLLDRAETVRLTDRSTAWYDWERYSKRQDKRMKMGGFVGDMTFEGDLEQFLPLLVLGSWVNLGKGTSFGLGRYSLAPLEGHALAD
>NC_008554.1|WP_011698211.1|1672746_1675293_-|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MAYTMHEVVVGALLHDVGKFLQRAYDRLSDVTGQHLDLESTLCPQQKSVYTHKHVLFTNAFFDLMSKEEVYFPAGINAKTVEDISSYHHKPDACPIPGASWLCALGDRLSAGMDRRDDEETSERASSRSTFKKTPLRCIFDEVILDPKALGMPQAHAYRLGVLNPEDAESMIPIAWPSKGEVPELPKRYQEVWQQFWGEIKVLGREAPRLSFDLFEEALLGLLERYTWAIPSSTVNSPDISLYDHARTTAAIAACLYRYHDAKGQLEDVKAIRDEQQMKFRLLAGDLSGIQNTLFSLQTQGVKGVNKILRARSFMMSGVSEAAALLSIELLSLPICTVLQQAGGRFLILVPALGDTEDHVDGLRERFDKWLVEHYTGSLALNLVLSPPFSASSFKPHPLREIMAGLGQAIEDGKQRPLSKCSQGVLKREYPLDALCSACGVRPAVTTGAAESGYRCLTCHDEFRIGRDLVGATVMVWGRSLPREWNPVDVIGLELALLRNHPENLPGEALSVRRTSPLHMPIPWAVRNLANHIPVFKDHYETQDPRYEGSWDDDVVPRIGEPKSFAHIAADALEPEKDSGAFRGKAFLALLKADVDYLGFLFNFGLKRTEAEEDRFTLSRIAQLSRMVDLYFTGYLKGLLHREFPDTYTIYAGGDDLLFIGPWRQTLALTSRVNETFRAYTGHNPNITLSAGVSLLKPNYPVNRAVLEAQEYLDECKYHGRNRVCALLEKPVSWECYIARLKDAEWVHQRMHDDSPVSTSFIYRLLVIAMDAEAVAIKANVQKAGWRARLAYHLARNIKARNNQEKEKMIVEWLEHLGLDDQLKLTTKHTNIIDWRLPLTVALYRNRT
>NC_008554.1|WP_011698210.1|1672216_1672729_-|type-III-A-CRISPR-associated-protein-Csm2
MSQYSHSGYGRSGQGRYGQGSSRQGARGGQQGAVGEQLPTPTPVKYFTDEEKRKLDPSLVDARAASWASSFRDLKSTQMRRFYDEFKAIERKILRGKVEEQVANFERDMALVMMFKAKAVYAEKRKVSPREFTQFIFDHMASIKDLKDFQAFIKVFEAVVAFHRFYAKDN
>NC_008554.1|WP_011698209.1|1671476_1672202_-|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MRLVASKILTGHIRVLTGLHIGAGKDAIEIGGVDSPVVKNPYTDEPYIPGSSLKGKLRCLMEWATNRVEESGKTWEGGGEKDPVRLAQDPVLRIFGTTSKQWVAGPTRLVVRDCSLNEQWRDSLIGRGLPFTEEKFENNIDRIQGKAGVGIRKTERVPAGAVFDLMMVYRVFDTGDQGEQDKRLFKEFLRVMRLLEHDALGGSGSRGYGRIKFENLRVDGEDFQQQFLAIAPEEIIQHSRS
>NC_008554.1|WP_011698219.1|1689481_1691836_-|hypothetical-protein
MNKLKWLGLILVFLVAAAPAVHAQPQASEDDEAVLVGRISHVEGQLLRYVPDEKDWVATVQDAPFGLDDALYSDQDGKAEFIMPNNSWARISGDTQIQLITLKPDATVIDVASGVTRFYDKSSEAVIQATTPFGYVMAQPGAVFDLYVGDQSAEVIAIKGDVDFVHNATGTKYEVLPGASSIVADEREVASGEGNVDADWDDWNANRDALWSKRMTVRGDSVKYLPPAIQDDAYALDESGRWEEVEYEGRRQRLWRPVRVERDWAPFTAGRWTVWNEDNTWVPEEPFGYVTHHYGNWVMVGNAWFWAPPVVRVRVTPGVVGFGWYPGRVAWIGTGAQVGWIPLAPMEPYYCHRRWGPRAVVVTNVAAVRINIGSYRWYNRAVVVNHNNFYGVRNYRNVRVTNINHTTIINNFRGAPVVNNTVVNNYNTDRRRYNFSNVNVVRKPHQTVVNRIVQNERLAKQESPRMNAALIRQNAANARKAAPVQKAVVERPRITNKVVSAGEVNKPASEVRFQQREIKQRVRPAAEVRGRGSDAPTAGPRTVPGQVQPARPGDGGPAGRREVTKPGGQLQPARPGEQVQPGRPGTGREVSEPRGPRQPEQRIKRDEPSQQGPGQRPQLQDQRRPPAQDDRRTIKPQEQQPQRRPDMQEQKRPGVQEQRRPQMQEQRRPEVQEQRRPQVQEQRRPPAQDDRRTIKPQEQQPQRRPEVQEQRRPQVQEQRRPQMQEQRRPQVQEQRRPQMQEQRPGAQQPRQQQGVQQPRPQQGQQPQHGQQQGPAGKKKADEKP
>NC_008554.1|WP_167321391.1|1692593_1692644_-|hypothetical-protein
MNGWTLCNKCNRVQIL
>NC_008554.1|WP_011698221.1|1692761_1694333_-|AMP-binding-protein
MLITEMLARNARLYPDEVALVERDPAQKSRREISWRTFDEQANRVATALLQRGVGKGDRVVHLLMNCLEWLPIYFGILRTGALAVPLNFRFDAAAIERCVQVTEAGTFFFGPEFVDRVNAVRERLDTVKSYVFVGPDEVRPDYAEDYGAFLASGSALDPRVDLNTLDDAALYFTSGTTGSPKATLLTHRNLEFACYAENSHHHQTHADNFLCIPPLYHTGAKMHWFGNLIVGARAVVLRGTEPRWILEAVSEEKVTIVWLLVPWALDILFAVENRDVKLSHYNLRQWRLMHIGAQPVPPSLVKQWKKVFPHHQYDTNYGLTECTGPGCVHLGVENMHKVGAIGVPGFDWEIKIVSSGREPVAKGEIGELAVKGPGVMKEYYRNPEATREVLDDGWLFTGDMARQDEDGFIWLVDRKKDVIITGGENIYPVEIEDFLQAHPKIRDVAVIGLPSARLGELATAVVQVKTGQELTEREVMDFCEGLPRYKRPRRIIFAAVPRNPTGKIEKPLLRKRYAGTEQSFSL
>NC_008554.1|WP_011698222.1|1694891_1696007_-|radical-SAM-family-heme-chaperone-HemW
MSSVEAAGLYVHIPFCRSKCPYCDFYSTTSLELLPLWLEAVVKEIDGYRGRFALFDSLYLGGGTPSLVDAARLGALIDHLRRAFSFSDDTEITLEANPDDITPGRLREVLDLGVNRISLGVQSLDEGELRLLKRRHTALQAEEALAIIRSAGFENVGIDLIYGLPGQTVPGWLKTLDRALGFGPEHLSCYQMTYEEGTLFGKKLKKGTMRPLGEDVERAFFLRTSRFLEKRGYLHYEISNFARAPEFVSRHNRKYWRRVPCLGLGPSAHSFDNDSRWWNVRSVSDYARRLMSGQSPVAGREILTPEQVQLERLSLGLRTSDGVPLETFASCADYSGVLTRLSDSGLIEIRGGSVVPTRKGFLVADGLALLF
>NC_008554.1|WP_011698223.1|1695999_1697796_-|elongation-factor-4
MTKIRNFSIIAHIDHGKSTLADRLIQRAGLVTDRQFRDQILDNMDIERERGITIKSQTVTLPYRSRNGEEVELNLIDTPGHVDFSYEVSRALASCEGVLLLVDASQGVQAQTLANLYAAMEHDLTIIPVINKIDLLSADIENTRAQIESELGLDSSQAVLCSAKEGRGIDDVLEAVVDRIPPPSGKLDAPLSALIFDAHYDSFRGTIVACRVFDGSVRPGDVIRFMSNGATYKVEEVGVFRLSREPKKELRAGMVGYVISGVKTVSDTRVGDTITLDSNPVPAPLPGFKEVKPVVFSSIYPISSDDYLSLADSLEKYKLNDAALIYQKDSSVALGQGFRCGFLGLLHLEIVQERLEREYDQSIIMTFPSVQYVLTLEDGSTTMVDNPQYYPDPIRIRTSAEPFIKASIIIPERYMGAVMKLCLDKRGVNPRFNYPTPGRIEISMEMPLAEVVFDFYDKLKTVTQGYGSFDYDLIEHRVSDLVKLDILVNSEKVDALSLIVHRERAREWAVQVCDRLKEEIPRHQFKIAIQGAIGGKIIARSTVNAFRKDVTAKCYGGDISRKRKLLEKQKKGKKRMKMVGSVMIPQSAFVAVLKADNE
>NC_008554.1|WP_011698224.1|1698282_1698603_+|hypothetical-protein
MKTVRILIALSVLCALASCSLKQGWDLAGKWQKIEGAETVEFTAKGTVVLVSGETSVTAPYTVLDAKHLQLNLGGLGTVVVGAEVAGDTLTLTDAKGQAVKYKKAK
>NC_008554.1|WP_011698225.1|1698893_1699715_-|hypothetical-protein
MKKLRSRGVGALLVFFFAFMGLMCGTAPAGADEQGACEDVKLTGSGSVDFLSQYIWRGYALSAGSAVMQPSFTLGSHGFSFNVWGNFDTAQELFSRGAKWNETDFTGSYSRELFKNFTGTVGTIYYNLPNGRFDALEVYGGVSYAFPWFTVGFTTYREVTHTPGWWMQLDLSRNFPLPWCGMSVDLGMTFGYLVLLDDDTLVHPSGRLDSYSAFHSGTLNAGLRIPVLKWLTLTPKIGFAFPLTGEAADIIEANSWDGESSHVFGGLNITAAF
>NC_008554.1|WP_153307204.1|1699769_1699928_+|hypothetical-protein
MKTAHLIRTGFDSTREVANSRKLAIGDRTGIGARIEKTAQRVEALVYPELTD
>NC_008554.1|WP_011698227.1|1700426_1700843_+|hypothetical-protein
MNVKELEQLMEQAMTSEWEVTSTGTGFLVATDWRLPNNERIEIFVRTVGEREDLFLVTDGGEVFNFLFSHGIDLSKDTRGMKTLNGVSERYQAKIVNYQITRGSGRADLARSIRLMLEAVKDASFLLWHKLVPDSSIH
>NC_008554.1|WP_011698228.1|1701059_1702466_-|glutamate--tRNA-ligase
MEPVITRFPPSPTGDLHIGGARTALFNWLFARHFGGRFILRIEDTDLVRSTESSIKAILDAMEWLSLDWDEGPYYQTKRLDVYKDYLQRMVDGGAAYYCDCAPDDLERRRKSAMAEGRKPKYDGRCRDRGLGPGPDRVLRFRCPDSGTTVLNDIIKGPIFFENAELDDLVLQRSDGMPTYNFAVVVDDVTMNITHVIRGDDHVNNTPRQILIYQALGARLPYFAHVPMILGEDRARLSKRHGATSVMAYRDMGILPEALINYLVRLGWSHGDQEIFTRRELIETFSLENVGKSASVFNPEKFLWLNAHYLRERSPEALVPLLQPFLDAKGYPARSPEYVARAIPTLQPRVRTLVEMAEQMRFYLVDEVEYDPEAARKFLVSAMREPFNRLLAELAALDGFSHERLESVFQQIVSELGLKLGKVAQPVRVALTGGTVSPGLFEIIDVLGKDAVLKRLNNALRFIDRQAG

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Crispr_ID: NC_008554_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_11

1702547-1702639

Unclear

Consensus_repeat	Method
CTATTTTCATGCTTCGCGGGTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_11

>merge|NC_008554|11|1702547-1702639|CRISPRCasFinder
CTATTTTCATGCTTCGCGGGTGACGCCGGCGACATGGGGAATTACCTAGAAAATAGATTCCCTCGGGAGTCTGTTTTCATGCTTCGCGGGTGA

>NC_008554|11|11|1702547-1702639|CRISPRCasFinder
CTATTTTCATGCTTCGCGGGTGA	CGCCGGCGACATGGGGAATTACCTAGAAAATAGATTCCCTCGGGAGT
CTGTTTTCATGCTTCGCGGGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011698231.1\|1704634_1704817_+\|50S-ribosomal-protein-L32	unknown	unknown	gnl\|CDD\|237038
NC_008554.1\|WP_011698229.1\|1703238_1703748_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698238.1\|1711803_1712244_+\|ribose-5-phosphate-isomerase-B	unknown	unknown	gnl\|CDD\|376799
NC_008554.1\|WP_011698224.1\|1698282_1698603_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376116
NC_008554.1\|WP_011698223.1\|1695999_1697796_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_008554.1\|WP_011698236.1\|1709678_1710422_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|235500
NC_008554.1\|WP_167321391.1\|1692593_1692644_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698221.1\|1692761_1694333_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235730
NC_008554.1\|WP_011698233.1\|1705979_1707149_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NC_008554.1\|WP_011698222.1\|1694891_1696007_-\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|223708
NC_008554.1\|WP_153307204.1\|1699769_1699928_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698225.1\|1698893_1699715_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273922
NC_008554.1\|WP_011698227.1\|1700426_1700843_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698237.1\|1710505_1711762_+\|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl\|CDD\|274452
NC_008554.1\|WP_011698219.1\|1689481_1691836_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NC_008554.1\|WP_011698235.1\|1707965_1709165_+\|electron-transfer-flavoprotein-subunit-alpha	unknown	unknown	gnl\|CDD\|224936
NC_008554.1\|WP_011698232.1\|1704849_1705911_+\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_008554.1\|WP_011698230.1\|1703847_1704402_+\|DUF177-domain-containing-protein	unknown	unknown	gnl\|CDD\|376863
NC_008554.1\|WP_011698228.1\|1701059_1702466_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_008554.1\|WP_011698234.1\|1707177_1707969_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698231.1\|1704634_1704817_+\|50S-ribosomal-protein-L32	gnl\|CDD\|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	5.36898e-28
NC_008554.1\|WP_011698238.1\|1711803_1712244_+\|ribose-5-phosphate-isomerase-B	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	4.55543e-80
NC_008554.1\|WP_011698224.1\|1698282_1698603_+\|hypothetical-protein	gnl\|CDD\|376116	pfam18692, DUF5640, Family of unknown function (DUF5640). This domain is found in proteins of unknown function. It has composed of eight antiparallel beta strands and carries a G-X-W motif in the N-terminal region. The conserved glycine-X-tryptophan (G-X-W) motif is characteristic for the lipocalin family.	8.04647e-06
NC_008554.1\|WP_011698223.1\|1695999_1697796_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_008554.1\|WP_011698236.1\|1709678_1710422_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	2.41772e-126
NC_008554.1\|WP_011698228.1\|1701059_1702466_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_008554.1\|WP_011698233.1\|1705979_1707149_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	2.51968e-167
NC_008554.1\|WP_011698222.1\|1694891_1696007_-\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|223708	COG0635, HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism].	1.73715e-121
NC_008554.1\|WP_011698225.1\|1698893_1699715_-\|hypothetical-protein	gnl\|CDD\|273922	TIGR02001, gcw_chp, conserved hypothetical protein, proteobacterial. This model represents a conserved hypothetical protein about 240 residues in length found so far in Proteobacteria including Shewanella oneidensis, Ralstonia solanacearum, and Colwellia psychrerythraea, usually as part of a paralogous family. The function is unknown.	2.911e-05
NC_008554.1\|WP_011698230.1\|1703847_1704402_+\|DUF177-domain-containing-protein	gnl\|CDD\|376863	pfam02620, DUF177, Uncharacterized ACR, COG1399. This family is nearly universally conserved in bacteria and plants except the Chlorophyceae algae. Thus far, mutantional analysis in bacteria have not established a function. In contrast, mutants have embryo lethal phenotypes in maize and Arabidopsis. In maize, the mutant embryos arrest at an early transition stage.It has been suggested that family members specifically affect 23S rRNA accumulation in plastids as well as bacteria.	5.44479e-29
NC_008554.1\|WP_011698237.1\|1710505_1711762_+\|beta-ketoacyl-ACP-synthase-II	gnl\|CDD\|274452	TIGR03150, fabF, beta-ketoacyl-acyl-carrier-protein synthase II. 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NC_008554.1\|WP_011698219.1\|1689481_1691836_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	2.82209e-11
NC_008554.1\|WP_011698235.1\|1707965_1709165_+\|electron-transfer-flavoprotein-subunit-alpha	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	8.21263e-121
NC_008554.1\|WP_011698232.1\|1704849_1705911_+\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	2.20917e-111
NC_008554.1\|WP_011698234.1\|1707177_1707969_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	4.64936e-99
NC_008554.1\|WP_011698221.1\|1692761_1694333_-\|AMP-binding-protein	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	1.33801e-140

>NC_008554.1|WP_011698228.1|1701059_1702466_-|glutamate--tRNA-ligase
MEPVITRFPPSPTGDLHIGGARTALFNWLFARHFGGRFILRIEDTDLVRSTESSIKAILDAMEWLSLDWDEGPYYQTKRLDVYKDYLQRMVDGGAAYYCDCAPDDLERRRKSAMAEGRKPKYDGRCRDRGLGPGPDRVLRFRCPDSGTTVLNDIIKGPIFFENAELDDLVLQRSDGMPTYNFAVVVDDVTMNITHVIRGDDHVNNTPRQILIYQALGARLPYFAHVPMILGEDRARLSKRHGATSVMAYRDMGILPEALINYLVRLGWSHGDQEIFTRRELIETFSLENVGKSASVFNPEKFLWLNAHYLRERSPEALVPLLQPFLDAKGYPARSPEYVARAIPTLQPRVRTLVEMAEQMRFYLVDEVEYDPEAARKFLVSAMREPFNRLLAELAALDGFSHERLESVFQQIVSELGLKLGKVAQPVRVALTGGTVSPGLFEIIDVLGKDAVLKRLNNALRFIDRQAG
>NC_008554.1|WP_011698227.1|1700426_1700843_+|hypothetical-protein
MNVKELEQLMEQAMTSEWEVTSTGTGFLVATDWRLPNNERIEIFVRTVGEREDLFLVTDGGEVFNFLFSHGIDLSKDTRGMKTLNGVSERYQAKIVNYQITRGSGRADLARSIRLMLEAVKDASFLLWHKLVPDSSIH
>NC_008554.1|WP_153307204.1|1699769_1699928_+|hypothetical-protein
MKTAHLIRTGFDSTREVANSRKLAIGDRTGIGARIEKTAQRVEALVYPELTD
>NC_008554.1|WP_011698225.1|1698893_1699715_-|hypothetical-protein
MKKLRSRGVGALLVFFFAFMGLMCGTAPAGADEQGACEDVKLTGSGSVDFLSQYIWRGYALSAGSAVMQPSFTLGSHGFSFNVWGNFDTAQELFSRGAKWNETDFTGSYSRELFKNFTGTVGTIYYNLPNGRFDALEVYGGVSYAFPWFTVGFTTYREVTHTPGWWMQLDLSRNFPLPWCGMSVDLGMTFGYLVLLDDDTLVHPSGRLDSYSAFHSGTLNAGLRIPVLKWLTLTPKIGFAFPLTGEAADIIEANSWDGESSHVFGGLNITAAF
>NC_008554.1|WP_011698224.1|1698282_1698603_+|hypothetical-protein
MKTVRILIALSVLCALASCSLKQGWDLAGKWQKIEGAETVEFTAKGTVVLVSGETSVTAPYTVLDAKHLQLNLGGLGTVVVGAEVAGDTLTLTDAKGQAVKYKKAK
>NC_008554.1|WP_011698223.1|1695999_1697796_-|elongation-factor-4
MTKIRNFSIIAHIDHGKSTLADRLIQRAGLVTDRQFRDQILDNMDIERERGITIKSQTVTLPYRSRNGEEVELNLIDTPGHVDFSYEVSRALASCEGVLLLVDASQGVQAQTLANLYAAMEHDLTIIPVINKIDLLSADIENTRAQIESELGLDSSQAVLCSAKEGRGIDDVLEAVVDRIPPPSGKLDAPLSALIFDAHYDSFRGTIVACRVFDGSVRPGDVIRFMSNGATYKVEEVGVFRLSREPKKELRAGMVGYVISGVKTVSDTRVGDTITLDSNPVPAPLPGFKEVKPVVFSSIYPISSDDYLSLADSLEKYKLNDAALIYQKDSSVALGQGFRCGFLGLLHLEIVQERLEREYDQSIIMTFPSVQYVLTLEDGSTTMVDNPQYYPDPIRIRTSAEPFIKASIIIPERYMGAVMKLCLDKRGVNPRFNYPTPGRIEISMEMPLAEVVFDFYDKLKTVTQGYGSFDYDLIEHRVSDLVKLDILVNSEKVDALSLIVHRERAREWAVQVCDRLKEEIPRHQFKIAIQGAIGGKIIARSTVNAFRKDVTAKCYGGDISRKRKLLEKQKKGKKRMKMVGSVMIPQSAFVAVLKADNE
>NC_008554.1|WP_011698222.1|1694891_1696007_-|radical-SAM-family-heme-chaperone-HemW
MSSVEAAGLYVHIPFCRSKCPYCDFYSTTSLELLPLWLEAVVKEIDGYRGRFALFDSLYLGGGTPSLVDAARLGALIDHLRRAFSFSDDTEITLEANPDDITPGRLREVLDLGVNRISLGVQSLDEGELRLLKRRHTALQAEEALAIIRSAGFENVGIDLIYGLPGQTVPGWLKTLDRALGFGPEHLSCYQMTYEEGTLFGKKLKKGTMRPLGEDVERAFFLRTSRFLEKRGYLHYEISNFARAPEFVSRHNRKYWRRVPCLGLGPSAHSFDNDSRWWNVRSVSDYARRLMSGQSPVAGREILTPEQVQLERLSLGLRTSDGVPLETFASCADYSGVLTRLSDSGLIEIRGGSVVPTRKGFLVADGLALLF
>NC_008554.1|WP_011698221.1|1692761_1694333_-|AMP-binding-protein
MLITEMLARNARLYPDEVALVERDPAQKSRREISWRTFDEQANRVATALLQRGVGKGDRVVHLLMNCLEWLPIYFGILRTGALAVPLNFRFDAAAIERCVQVTEAGTFFFGPEFVDRVNAVRERLDTVKSYVFVGPDEVRPDYAEDYGAFLASGSALDPRVDLNTLDDAALYFTSGTTGSPKATLLTHRNLEFACYAENSHHHQTHADNFLCIPPLYHTGAKMHWFGNLIVGARAVVLRGTEPRWILEAVSEEKVTIVWLLVPWALDILFAVENRDVKLSHYNLRQWRLMHIGAQPVPPSLVKQWKKVFPHHQYDTNYGLTECTGPGCVHLGVENMHKVGAIGVPGFDWEIKIVSSGREPVAKGEIGELAVKGPGVMKEYYRNPEATREVLDDGWLFTGDMARQDEDGFIWLVDRKKDVIITGGENIYPVEIEDFLQAHPKIRDVAVIGLPSARLGELATAVVQVKTGQELTEREVMDFCEGLPRYKRPRRIIFAAVPRNPTGKIEKPLLRKRYAGTEQSFSL
>NC_008554.1|WP_167321391.1|1692593_1692644_-|hypothetical-protein
MNGWTLCNKCNRVQIL
>NC_008554.1|WP_011698219.1|1689481_1691836_-|hypothetical-protein
MNKLKWLGLILVFLVAAAPAVHAQPQASEDDEAVLVGRISHVEGQLLRYVPDEKDWVATVQDAPFGLDDALYSDQDGKAEFIMPNNSWARISGDTQIQLITLKPDATVIDVASGVTRFYDKSSEAVIQATTPFGYVMAQPGAVFDLYVGDQSAEVIAIKGDVDFVHNATGTKYEVLPGASSIVADEREVASGEGNVDADWDDWNANRDALWSKRMTVRGDSVKYLPPAIQDDAYALDESGRWEEVEYEGRRQRLWRPVRVERDWAPFTAGRWTVWNEDNTWVPEEPFGYVTHHYGNWVMVGNAWFWAPPVVRVRVTPGVVGFGWYPGRVAWIGTGAQVGWIPLAPMEPYYCHRRWGPRAVVVTNVAAVRINIGSYRWYNRAVVVNHNNFYGVRNYRNVRVTNINHTTIINNFRGAPVVNNTVVNNYNTDRRRYNFSNVNVVRKPHQTVVNRIVQNERLAKQESPRMNAALIRQNAANARKAAPVQKAVVERPRITNKVVSAGEVNKPASEVRFQQREIKQRVRPAAEVRGRGSDAPTAGPRTVPGQVQPARPGDGGPAGRREVTKPGGQLQPARPGEQVQPGRPGTGREVSEPRGPRQPEQRIKRDEPSQQGPGQRPQLQDQRRPPAQDDRRTIKPQEQQPQRRPDMQEQKRPGVQEQRRPQMQEQRRPEVQEQRRPQVQEQRRPPAQDDRRTIKPQEQQPQRRPEVQEQRRPQVQEQRRPQMQEQRRPQVQEQRRPQMQEQRPGAQQPRQQQGVQQPRPQQGQQPQHGQQQGPAGKKKADEKP
>NC_008554.1|WP_011698229.1|1703238_1703748_+|hypothetical-protein
MKSIIRVLACCLVLLSLCACGSSKEPAASTATGPPPNSPTKIRVVDVSNSTGELFDVDVIGLLWSGLDDALKKRGMFWTPDSPNPPLTIEAQVVKYRKGSAVARGMLVPYWGNTVLVAKCELKEGDRVIASAESKQSVSLGHGGIAIGGWRKVFSAVGEELVSKVVRPM
>NC_008554.1|WP_011698230.1|1703847_1704402_+|DUF177-domain-containing-protein
MRIRVDEIPESGRFLHFHWDEDHLRQFLPPEDPFEIELVRPVNVDLEIQKRIDHIRITGTIRGVLRLGCHRCLKPFQWSMDETVDVFLLEEEKAPQEEELELEDEELDFEFFDGQIIEIDQLVAEQIFLALPFKVLCSEDCRGICPRCGVNLNDEECRCAMEKEPSAFSRLEAIKSRLPGWREE
>NC_008554.1|WP_011698231.1|1704634_1704817_+|50S-ribosomal-protein-L32
MGVPKRKTSKGRRDKRRAHLALSGPALAKCPQCNEMRLPHRVCPACGYYRDRAVLEFEEE
>NC_008554.1|WP_011698232.1|1704849_1705911_+|phosphate-acyltransferase-PlsX
MKIAVDAMGGDHAPEALIEGALLAGPQCSADILVIGNEARLSSLLAHSGDSTSLKVVHAPQVIGMGEAGPMALRRKREASLTIAMRLLAENEVDAVVSAGNSSAVVSAARHLVGLIPGLRRPAMAVPLPTPSGKLLLLDAGAHAEATAIHLAQSAVLAHCYLKIEEGLNRPRIGLLNIGHEPAKGNRAVQRAFALLRRCSLEFTGNVEPNDLFAGKVDAVICDGFVGNVLLKMYEGFSETVCRFLESLANHDGRDFSGGAGRILERFRRDYHYEFVGGAPLLGIRKTVVAAHGRSRATAIANAIRLACRLQEARVFERLAGIVEEDGALTELRHQNTLLMIDQLKDKWGFAHR
>NC_008554.1|WP_011698233.1|1705979_1707149_+|acyl-CoA-dehydrogenase
MDYFLTEEQVMIQELAGQIAREKIRPVRAQLDEQEEFPWEIMKICAQADLFGLYIPEEYGGLGGGILENCLAIEKIAEACIGIATSFAASGLGAYPILLFGSEALKRAYLPDIASGKRLAAFGLTESGAGSDVSGIQTTAVRDGDHYVLNGAKQWITNGGEAEIYSVLAITDRSKGPRGASFFVVEKDDPGFSFGKKEKKLGIRASATRELVFQDCRIPKERLIGREGTGFIVAMKTFDKSRPGIGALGVGLSQGALDISVEYARKRMQFGKPIISFQAIQHKLADMAIKTEAARALIYAAARYMDTDPPDSSKVAAMCKVFAGDAALYAATEAVQILGGYGYMQDYPVEKMMRDAKILQIYEGTNEIQRNIIGQELNKEYSRLKESFF
>NC_008554.1|WP_011698234.1|1707177_1707969_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MHIVVCIKQVPDTKNVRIDPDTHTLVRQGVESIINPFDLFAVEAGLQLKDKLGATVTAVTMGPPQAGDALRDTLSLGVDDAVLLSDRAFAGSDTWATATTLSAAIRKIGDVDLVICGKQAVDGDTAQVGPEMAALLDFPYATYVKSMQKLDERHFKVTRQTDEGVEVWKVPLPMLITVIKEMGEPRVPSLRHKMRAKKAEIPVWGAADLGLDPNSVGLCGSFTQVVRVFSPPRRTNRIQLSGTVQEQAEQLYRHLKQAKVPGI
>NC_008554.1|WP_011698235.1|1707965_1709165_+|electron-transfer-flavoprotein-subunit-alpha
MKAIVDRKKCTVCGVCTDVCPMGAISLKETEIEISDDCSLCGMCVDTCEFGALSLPQVGTGPAADIAAYSGVWVFAEWRSGTIHKVSHELLSAGRVLANKRGVPLAAVLLGHRLDDAISEELISYGADVVYVVDHPELAGFRDDTYANILVELIRRKRPEILLAGATSIGRSFIPRVAASVRTGLTADCTDLDISEDGLLLQTRPAFGGNVMATIVCPNSRPQMATVRPKVMKPVPVPGHKGSVELVTAPEEWLRSRVEVLEVIPEADKTAKLTEADVIVSGGRGLRKPENFKLLEDLAGLLNGAVGASRGAVEEGWIAPSHQVGQTGRTVAPILYMAVGLAGAIQHVVGMQGSRIIVAVNRDPQAPIFDVASFGVVADLFEFVPEFIKRIRTERGESS
>NC_008554.1|WP_011698236.1|1709678_1710422_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MSEKRVAVVTGASRGIGRGIAVALARPGYDIIVNYNASPGPAEETAAAVAARGGSAHLHRFNIADADSVKEAFKEIIKTYGRVDVLVNNAGIARDNLLVLMKASEWDEVLDTNLRGAFLCTQAVVKQMLRQRYGRIVNVTSVVGVIGNAGQCNYSAAKAGLIGFTRSIARELVSRNITVNAVAPGFIETDMTLALPETARQSLLQQIPAGRCGTPEDIAAAVVFLASEAAGYITGQVIHVNGGMFMG
>NC_008554.1|WP_011698237.1|1710505_1711762_+|beta-ketoacyl-ACP-synthase-II
MESRKNRRVVITGIGLVSPLGVGIEENWTNLIQGKSGIRAITGFDASAYATRIAGEVKNFHPEDFIPKKELRKMDPFLKLCLGASRLAFEDGGFEIPPELAHRAGVVMGCGLGGLLTLEESHKVLLDLGPRKVSPFFIPMLIGNMAPGLISIYHGAKGPNLSIQTACAAGTHAVGEAFHMVRSGISDIMITGGVESTVTSLCVAGFNAMRALSTRNDEPEKASRPFDRDRDGFVLGEGSAVLILQELEMALARGARIYAEVIGFGATGDAFHMAAPAPNGEGAARCMQMALDDAGIEPSAVDYINAHGTSTDLNDKYETQAIKTIFEAHASKLAVSSTKSMTGHLLGAAGGVEAAYTALTLERQIMPPTINYENPDPDCDLDYVPNQARPGHIEVAMSNSFGFGGTNGTLVFRRWTGK
>NC_008554.1|WP_011698238.1|1711803_1712244_+|ribose-5-phosphate-isomerase-B
MKIMVGCDHGGFELKEKIVAHLGTLGHEVVDAGTNSLESVDYPHYAMKVARAVARGEADRGILVCGSGIGMNMTANRVSGIRAVLAYEPYGAIMSRRHNDSNVLCMGGRFTGLDMALQIVDVWLREPFEGGRHQRRIELIDRLVDA

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Crispr_ID: NC_008554_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_12

1843038-1843129

Orphan

Consensus_repeat	Method
TCTGACGGGCACATCGGTCCGTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_12

>merge|NC_008554|12|1843038-1843129|CRISPRCasFinder
TCTGACGGGCACATCGGTCCGTGAGGGCGGGGTTTATCCCGCCCGCGTTACCTCCTGACGGGCGGGTTCTGACGGGCACATCGGTCCGTAGC

>NC_008554|12|12|1843038-1843129|CRISPRCasFinder
TCTGACGGGCACATCGGTCCGTGAG	GGCGGGGTTTATCCCGCCCGCGTTACCTCCTGACGGGCGGGT
TCTGACGGGCACATCGGTCCGTAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011698353.1\|1849387_1850836_+\|type-II-and-III-secretion-system-protein-family-protein	unknown	unknown	gnl\|CDD\|227299
NC_008554.1\|WP_011698356.1\|1852083_1853367_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378335
NC_008554.1\|WP_011698349.1\|1846844_1847018_+\|Flp-family-type-IVb-pilin	unknown	unknown	gnl\|CDD\|368212
NC_008554.1\|WP_011698351.1\|1847840_1848404_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|366666
NC_008554.1\|WP_011698355.1\|1851560_1852043_+\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|377921
NC_008554.1\|WP_011698336.1\|1832486_1834079_+\|aspartate:alanine-antiporter	unknown	unknown	gnl\|CDD\|225532
NC_008554.1\|WP_011698354.1\|1850892_1851234_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698342.1\|1838199_1839042_+\|bile-acid:sodium-symporter	unknown	unknown	gnl\|CDD\|223462
NC_008554.1\|WP_011698343.1\|1839466_1840039_-\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|365959
NC_008554.1\|WP_150109460.1\|1837800_1838160_+\|STAS/SEC14-domain-containing-protein	unknown	unknown	gnl\|CDD\|378774
NC_008554.1\|WP_011698339.1\|1834984_1836739_+\|aldehyde-ferredoxin-oxidoreductase	unknown	unknown	gnl\|CDD\|225277
NC_008554.1\|WP_011698338.1\|1834544_1834988_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|319892
NC_008554.1\|WP_011698346.1\|1842204_1842870_+\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NC_008554.1\|WP_011698344.1\|1840266_1841007_-\|sel1-repeat-family-protein	unknown	unknown	gnl\|CDD\|276807
NC_008554.1\|WP_011698352.1\|1848457_1849336_+\|Flp-pilus-assembly-protein-CpaB	unknown	unknown	gnl\|CDD\|274472
NC_008554.1\|WP_083764187.1\|1837048_1837675_+\|DUF1269-domain-containing-protein	unknown	unknown	gnl\|CDD\|227140
NC_008554.1\|WP_011698347.1\|1843737_1845213_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NC_008554.1\|WP_011698345.1\|1841028_1841409_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NC_008554.1\|WP_011698348.1\|1845205_1846600_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_008554.1\|WP_011698350.1\|1847189_1847405_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226366

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698353.1\|1849387_1850836_+\|type-II-and-III-secretion-system-protein-family-protein	gnl\|CDD\|227299	COG4964, CpaC, Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion].	7.64189e-124
NC_008554.1\|WP_011698356.1\|1852083_1853367_+\|hypothetical-protein	gnl\|CDD\|378335	pfam09977, Tad_C, Putative Tad-like Flp pilus-assembly. This domain, found in various hypothetical prokaryotic proteins, is likely to be involved in Flp lius biogenesis.	2.22251e-11
NC_008554.1\|WP_011698349.1\|1846844_1847018_+\|Flp-family-type-IVb-pilin	gnl\|CDD\|368212	pfam04964, Flp_Fap, Flp/Fap pilin component.	5.12805e-11
NC_008554.1\|WP_011698351.1\|1847840_1848404_+\|prepilin-peptidase	gnl\|CDD\|366666	pfam01478, Peptidase_A24, Type IV leader peptidase family. Peptidase A24, or the prepilin peptidase as it is also known, processes the N-terminus of the prepilins. The processing is essential for the correct formation of the pseudopili of type IV bacterial protein secretion. The enzyme is found across eubacteria and archaea.	2.58706e-10
NC_008554.1\|WP_011698336.1\|1832486_1834079_+\|aspartate:alanine-antiporter	gnl\|CDD\|225532	COG2985, COG2985, Predicted permease [General function prediction only].	1.94657e-87
NC_008554.1\|WP_011698355.1\|1851560_1852043_+\|pilus-assembly-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	8.39306e-15
NC_008554.1\|WP_011698342.1\|1838199_1839042_+\|bile-acid:sodium-symporter	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	2.12739e-16
NC_008554.1\|WP_011698343.1\|1839466_1840039_-\|J-domain-containing-protein	gnl\|CDD\|365959	pfam00226, DnaJ, DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.	1.49904e-19
NC_008554.1\|WP_150109460.1\|1837800_1838160_+\|STAS/SEC14-domain-containing-protein	gnl\|CDD\|378774	pfam11964, SpoIIAA-like, SpoIIAA-like. These proteins adopt an alpha/beta SpoIIAA-like fold, similar to that found in STAT (pfam01740). They adopt open and closed conformations arising from different arrangements of their alpha-2 and alpha-3 helices. They may be membrane associated and may function as carriers of non-polar compounds.	1.44848e-18
NC_008554.1\|WP_011698339.1\|1834984_1836739_+\|aldehyde-ferredoxin-oxidoreductase	gnl\|CDD\|225277	COG2414, COG2414, Aldehyde:ferredoxin oxidoreductase [Energy production and conversion].	2.81949e-108
NC_008554.1\|WP_011698338.1\|1834544_1834988_+\|4Fe-4S-binding-protein	gnl\|CDD\|319892	cd16370, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	1.80549e-49
NC_008554.1\|WP_011698346.1\|1842204_1842870_+\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	1.45488e-14
NC_008554.1\|WP_011698344.1\|1840266_1841007_-\|sel1-repeat-family-protein	gnl\|CDD\|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	6.0236e-42
NC_008554.1\|WP_011698352.1\|1848457_1849336_+\|Flp-pilus-assembly-protein-CpaB	gnl\|CDD\|274472	TIGR03177, pilus_cpaB, Flp pilus assembly protein CpaB. Members of this protein family are the CpaB protein of Flp-type pilus assembly. Similar proteins include the FlgA protein of bacterial flagellum biosynthesis.	7.32408e-64
NC_008554.1\|WP_083764187.1\|1837048_1837675_+\|DUF1269-domain-containing-protein	gnl\|CDD\|227140	COG4803, COG4803, Predicted membrane protein [Function unknown].	9.81778e-54
NC_008554.1\|WP_011698347.1\|1843737_1845213_+\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	4.30569e-75
NC_008554.1\|WP_011698345.1\|1841028_1841409_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	3.70712e-06
NC_008554.1\|WP_011698348.1\|1845205_1846600_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_008554.1\|WP_011698350.1\|1847189_1847405_+\|hypothetical-protein	gnl\|CDD\|226366	COG3847, Flp, Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion].	0.000191768

>NC_008554.1|WP_011698346.1|1842204_1842870_+|isoprenylcysteine-carboxylmethyltransferase-family-protein
MKTQVKTSRMDIGRLVAAPVFALLLFFSARGLLGGLSSLFPLDAAKALLLVHRLLIVAFYVLIVVLYFMRTAASSTTRSIPARSIAVGASFLPFAIPLAGGASDASPVVMLGANVIMASGMAFALAALFALGRSFSIIPQTRSLVMHGPYRLVRHPLYLGELVTVAGFVLAGVAPAKVLIFVLLAACQVYRALQEEKLLAAMFPEYEGYASRTPRLLPGVF
>NC_008554.1|WP_011698345.1|1841028_1841409_-|PilZ-domain-containing-protein
METRQYKRFKAMDGALAVFSSTLQPNLPKLGRLLDISAGGLAFSYTARGIQTEGASSLRISWHDDELSTIEGIPFKIVYDVDLSGHYRLGLPEDRRCGVQFGDLTAEQSKQLVAFIRNYSRGEIAG
>NC_008554.1|WP_011698344.1|1840266_1841007_-|sel1-repeat-family-protein
MKSNPQTFSANPMLNRVRAAFALALWLLLLAVIPVHAGMKSGMAAYRRGDYGTALREFRAGAARGNTDAQKMLAAMYETGTGVTRDYGEAFKWYSAAARSGDSSAQFMVAQMYYEGRGGPRDLSEAVTWYRKAAEGGFPEAQYNLALFHEIGRGTQRDMNEASRWYRKAAEKGLPQAQARLGLMYVKGEGVLQDYVQAHMWLNLAASNGEEGARNALEALSAKMTSDQVAKAQEMARKWHAKKRGR
>NC_008554.1|WP_011698343.1|1839466_1840039_-|J-domain-containing-protein
MPASSFVDYYECMQLSPNADQETIERVYRLLAKRYHPDNPHTGDHDKFSRLTTAFRVLSNPEQRAAYDAGYEESRAAQWKLFIQADPAGGIDSDQLIRHSILSLLYTARRNNASKAGVGILHLEDLLSCPQHLMEFHIWYMKSKGWIVRTDTGELAITAEGVDEFTSGERHFVKDRLLPPGRQGREEAES
>NC_008554.1|WP_011698342.1|1838199_1839042_+|bile-acid:sodium-symporter
MNDFLAPAANLMLLLFVVSALLGTGLSLTLRQILEPLRSIRLVISSLAASFLLVPLIAVVLTRIHPLERPLRIGLILLSMTAGSEGLPKITGIVKGNTAYAVGLMCMQLVVSLVYVLSLISVLLPEVSVDHVKLATKLVVLVFLPLATGLLLKARRESAAVRLEHWLHKVSMFSLFLMFALFIAANYSAVLAILHFEAVLTVIVYLALSFIVGYLLGGPNPGTRTALAVGSLLRSGSIAMVVASQAFDDPRVIVMIISIFILMLPVLPVMIWVFRPRGSA
>NC_008554.1|WP_150109460.1|1837800_1838160_+|STAS/SEC14-domain-containing-protein
MACEIIRIDGALMHVRISGIMEPADQESLQTVAASLIAQGLKVRLLATLDDFEGWRKGADWGDIAFFMTHGNDVARMAIVGDERWKDQIFAFVGKGLRDTEVEFFPLSSEGEAERWVRA
>NC_008554.1|WP_083764187.1|1837048_1837675_+|DUF1269-domain-containing-protein
MLDTREGSVHAIDSFGAANRLAESFEEWIGPELLRAVLKEQYKSSLTVVIFDDEQKAEEARLKLLELRRGGFVELEDAVVVVRGQDGTVRHHQMHKLTRKGGIAGSITGLIVGSIFFSPVIGAVFGAVSGALSASLTDIGIDDRFVEDLSRKLKPGCSALFTLVRKADPERVREAFLGFGGKVLVNSVSKERETVLQEILDAAGEKTE
>NC_008554.1|WP_011698339.1|1834984_1836739_+|aldehyde-ferredoxin-oxidoreductase
MTGETREQFKVLVVDLPAGRGAITSLEGRDSLAGGSGLTAMLFDRYGLPDRPWDDPEQPLIFAIGPLTGYFPLMSKTVCAFKSPYHDQYAESHAGGRSALSLRFAGFDALVIRGKALAPSCLSVGSRHLELKDVHFLWGMDLLRTGKMLRRMYEGSGHRSILRIGPAGENGSAMACINVDTYRHFGRLGCGAVMGAKNLKGIVILGDGSSPLPEGKAYPKLFTEVYRKMTDTDMMEKYHNFGTPINMAILNGISALPIRNLQKTSDPGIEGITGETFARDTLLRNAACAGCPVGCVHLGFVRERFMEENRYLYRQVSYDHEPIFAAGAMLHVTNAFSVLTLLDTVEREGLDIMSAGVALAWATEALEKGIVTTRETIVPLKFGDETAYREGFHHLGAASNDFYRLLAQGTMKAAEHYGGADFACVLGQEMAGYATGEVFFVSQALGLRHSHLDAGGYSYDQKDKEPDVDGAVRFLVQDEQARVLLTSMVSCLFARGVYGDQVLSDCLRSLGYLNLADGLGDVSRNVRKLRWRTRLRTGFDPRTVSIPKRFLEVETWRGRIDSAYLNALKDAYAGAILALGEEDA
>NC_008554.1|WP_011698338.1|1834544_1834988_+|4Fe-4S-binding-protein
MKILTAPRMERCIGCHSCSLACARLVHKMLSWDMAGIRIASSGGLSTGFEARTCLACLPAPCAAACPTGAYAQRKGGGVIVRKNLCIRCGKCADACPVDAVFLAPDGEPFVCIHCGRCVVYCPHDCLELTDVGTEGAEESNARESAS
>NC_008554.1|WP_011698336.1|1832486_1834079_+|aspartate:alanine-antiporter
MEYVIALLSQQPLMTLFLVVAFGYLLGEVNIKGFSLGAGAVLFVALFVGWLAPKSAPAPLVGTLGLALFLYCVGIQYGKLFFTGLVSPTGRKANLLALIGLIVAGAAALASMNLFGLKPGYVLGVFAGSGTSTPALQAAMSSLGNSDPAVGYSATYPFGVAGPILVMYLAFFLFKPKIEVPKSAALDFMEIAVRNPDLFGKKLGDVLHMLPSQTEIAAVRHEGRNKFPDPALVLGPDDVLMITSATEAGLEEARKIIGEAAPGKIVMDRSALDYFRVFASKRAVVGTALGDLKIPGGFDYQLVQVTRGDSDLLPRRDLILEFGDRVGLLVNRANAQAVRAFFGDSIKGTADLSYISIGLGMALGLLVGLIPLPIPGLGKLTLGFAGLLLTALVLGYFRRSGGLHWTMPLSANLVLRNLGLTIFLAQVGISCGPKFAEALAESGFLLVFDGVLVLMSLVLPVMIIGMVVFKLPFDEVCGVVGGVTGNPAILMYAGKLTGTEKPDVGYAMIFPGATVMKILFVQIAAAIWGG
>NC_008554.1|WP_011698347.1|1843737_1845213_+|PAS-domain-containing-protein
MDKQGSTKPKVRLRLIVALPVATSILMLVGALLTSYLMPQQLPWPGQDSMPDLRTVILLSVFCTIILSFLLNLLAAFLISRNLKRLMVKASSMIPVGPESMQKSEAANEMKALGIILDEVEVTLDRFIQDSYILENLPEALITVDAAGEVRALNRRAARLFNTALWNIRGRRLEEIVPKSLRNESFHRMVLKGFEGTESHSSLIRLSTDAKAELVLWVGVSPVELSGGQRGVTISFKDQTDIVSVRNQIQKLERLAAVGKVSAHIAHEVRNPLGSIKTLTELIREDLRPDETQAKYADVILDQVGRLDRLIEDVLSFSRSSLLNVEKAELPVLLSQMIDLARHSFPEKGVNVEEQYDPVLPPVWCDPERLCQAFLNVLINAFEACAAGGHIKVSATYERGGTANGSVIGIRVKDDGPGIPESNLQKVFEPFFTTKSHGTGLGLACTYNIINAHGGRIEFANRPSGGASVHILLPENHTLESPLDEPVEYHG
>NC_008554.1|WP_011698348.1|1845205_1846600_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MAEKILIVDDDPGMQIALNEFLKKRGYETDSAVSAEEALDRVKHASYDLIFLDVRLPGMTGIDAICRIRNFDEQGEIIVITAHGTRDVALEAVRNGAYDYFTKPFSLQEMDVVIRRALEKRRLQKELSELRKRTGTTEPIDRIIGQSEGMKRVKAMVARIAPLETTVLVTGESGTGKELVADMLHMLSARASAPCIKINCASIPETLLESELFGYERGAFTGAVSSRQGKFEQAHTGTIFLDEIGDMPSSLQAKLLRVVEQKQVDRLGGKKPVKVDVRVVAATNRDLLELVTRKEFRADLYYRLNVAAIHVPPLRDRKEDLPLLVGHFLREINVKLGTDLSGISREAMELLFGHDWPGNVRELANLLERVAIVNRGTTVSPEAVTIALQKHSNTLAEEGGQAMSLGDTLDELERNLILDALRKCGGVQTRAAEMLGLSAKNFWKKMKKHGIRYDGERHTEEFSQ
>NC_008554.1|WP_011698349.1|1846844_1847018_+|Flp-family-type-IVb-pilin
MKKFIKFLKDEEGVTAIEYGLIAALIAVAIIVAVTSVGTNLTAVFNRVAAELLGALN
>NC_008554.1|WP_011698350.1|1847189_1847405_+|hypothetical-protein
MRGENNSGFESLLSGLRILLCEERGTTAIEYALIASLIVLAAASAMVATSDSVINIFNYWTNAVVSALSGG
>NC_008554.1|WP_011698351.1|1847840_1848404_+|prepilin-peptidase
MAASLNGILGGLLCVVLIVVAVEDMRKHRIRNVYTFPMVAVGLSFHALSGGLEGLVFSLKGLGLGIVFLIFPYLLGIMGAGDVKLMGAVGSILGSRGVFAAFLLTCVAGGVLAVILMVLNSKHTMKRLSAAWAAARRLPAEGRASGVPPGGDLKRPGLAYGAAIATGTIAFMALEWLGYDVSHLLWS
>NC_008554.1|WP_011698352.1|1848457_1849336_+|Flp-pilus-assembly-protein-CpaB
MARFRAIFPLALAIVLALVASVVVYKWVQMKTGVQTTVVTEKAEPGGVQVALASADLPWGTKLTREMVKMAEYPPKHLPAGYFSDPAKIEGRVLITPVKQGEQLLESKLAPLSVTTGGVSAVVSVGKRAIAVAGDKVIGLAGFIQPGNFVDVLVTIRDTQEKTPSTSKVVLENVKVLATGTVIDKKAGTEPGPVDVFTLEVTPEEAERLAFAASLGKLHFALRNVTDTEVVYTMGTTIADALDAYRPRMKMVSAQPVVKSEPEARKEQARSFSRMEIIKGSKVSQVDFENRR
>NC_008554.1|WP_011698353.1|1849387_1850836_+|type-II-and-III-secretion-system-protein-family-protein
MCSRLGLVGFVKASMVLAFSLVLISSSALHAAGPVKVVTGEHAARKIHLQVGKSVIVRSGAPVVRTTLGSPDVADIVALSPTQIYITGKATGVTNLTLWQSDDKVSAIYDIEVAPDTMRLKEKLHEVLPGERDIKVSASHDSLTLSGTISSSTHLAQAMTLAEAYSGGKKVINLLQVSGVHQVMLEVRVAEMSRTLTNRLGINSIWNVNGSMGASLLGNLASLDKFAGSASGSSSEFTFAPTVNSLFHILGGPFTWTAFIDALKEDGLVKVLAEPTLIAMSGQSASFLAGGEFPIPVPQGLGTVGIEYKQFGVSLAFTPTVLNDKRMNIIVAPEVSELDYTTAINIAGVAVPGLTTRKVSTAIELNDGQSFAIAGLLKDTIREDAKKFPILGSIPVLGALFRSVSFQRNETELIVIVTPRLAKPIDVATQPLPTDKFIEPSDSEFFFLGLLQGRAPKPAPRAPLPITDKKAGFDGEFGHTVP
>NC_008554.1|WP_011698354.1|1850892_1851234_+|hypothetical-protein
MKFKLFLVAVLLLVATVGSARAFEPDWPFDLYCCGPPPPEDTFGDAFRKARADQALNPDAGRDLAPVEGLDGRAAELVMDKYYKSFGKEGESSAGKTGGSYLPAAFIKQQGGK
>NC_008554.1|WP_011698355.1|1851560_1852043_+|pilus-assembly-protein
MKTKRVVPRFRKGVAAIEFALILPLLVLLLFGIIEFGIILYDQAVITNASREGARFGILYGAAADGTATPKSEAEVRQVVRNYAQQYLITFGTKVLGDADINVAEETVNGQNYRRVTISYPYTFIVLPRFITSFFGGGLGQDINLSANAVMRYEYQGPAV
>NC_008554.1|WP_011698356.1|1852083_1853367_+|hypothetical-protein
MKKHAIFSKSRLSERDGATVIIVALALVMLLGFGAFAVDIGYLYVVRNELQNAADAGALAGAAALYNNDGTAVQPTANVIGQEAAMRNTAVRTAVEVTLNGNSGDVQRGHYSFATGTFTPNASLLPVSLWNVSTEELDANTDFINAVKVTTHRSAPAAPSFFSRIFGYDSFALAAEAVAYIGFAGTLYPLNVDKPIAMCQESLLDAEGNYSCSIGRMINSGSGAGHNTAAWTNYSQPCETANANDMAQLLAGCGGSNPTPIILGTGMGTSGGMQDSTYRKSIFSCWIDSLRAGNPLPLVLPVVECPGNNPGPCSKVVGAVEVTVVWITDVINTNKLNYDEVPSMMNTAEKAPWACSVPLTKDSTQAQINQCWNEFVSYYNLKNADNQNAPIAKNSIYMLPSCTPHDPEGGTGGKNFGILAKIPVLVR

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Crispr_ID: NC_008554_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_13

2343394-2343489

Orphan

Consensus_repeat	Method
GTTGCGCCGTTGCGTGAGCATCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_13

>merge|NC_008554|13|2343394-2343489|CRISPRCasFinder
GTTGCGCCGTTGCGTGAGCATCCCCGGGTATTTCCCGTCAGCCCCCCGGTTTTCGCTCTTCCCTGGCCCGGGGTTGCGCCGTGGCGTGAGCATCCC

>NC_008554|13|13|2343394-2343489|CRISPRCasFinder
GTTGCGCCGTTGCGTGAGCATCCC	CGGGTATTTCCCGTCAGCCCCCCGGTTTTCGCTCTTCCCTGGCCCGGG
GTTGCGCCGTGGCGTGAGCATCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_150109635.1\|2346341_2347523_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698780.1\|2347823_2350190_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366045
NC_008554.1\|WP_011698775.1\|2340831_2341860_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NC_008554.1\|WP_167321333.1\|2355456_2356404_+\|UDP-3-O-acyl-N-acetylglucosamine-deacetylase	unknown	unknown	gnl\|CDD\|237294
NC_008554.1\|WP_049766346.1\|2352406_2352679_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_150109473.1\|2333899_2334502_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698768.1\|2332863_2333844_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_008554.1\|WP_011698773.1\|2336924_2338373_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|128563
NC_008554.1\|WP_011698771.1\|2335411_2335822_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_049766345.1\|2350092_2350998_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_008554.1\|WP_011698772.1\|2335814_2336837_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237564
NC_008554.1\|WP_011698782.1\|2351279_2352068_-\|DUF4412-domain-containing-protein	unknown	unknown	gnl\|CDD\|373032
NC_008554.1\|WP_011698776.1\|2341838_2342975_-\|carboxynorspermidine-decarboxylase	unknown	unknown	gnl\|CDD\|143502
NC_008554.1\|WP_011698770.1\|2334626_2335298_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341361
NC_008554.1\|WP_011698767.1\|2332154_2332760_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|214512
NC_008554.1\|WP_011698777.1\|2343498_2344677_-\|saccharopine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224662
NC_008554.1\|WP_011698778.1\|2345307_2346111_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_008554.1\|WP_011698785.1\|2353576_2355082_-\|threonine-synthase	unknown	unknown	gnl\|CDD\|107206
NC_008554.1\|WP_011698784.1\|2352829_2353378_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NC_008554.1\|WP_011698774.1\|2338673_2340686_+\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698780.1\|2347823_2350190_+\|hypothetical-protein	gnl\|CDD\|366045	pfam00350, Dynamin_N, Dynamin family.	7.50827e-10
NC_008554.1\|WP_011698775.1\|2340831_2341860_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	4.00193e-161
NC_008554.1\|WP_167321333.1\|2355456_2356404_+\|UDP-3-O-acyl-N-acetylglucosamine-deacetylase	gnl\|CDD\|237294	PRK13186, lpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase.	3.31123e-157
NC_008554.1\|WP_011698768.1\|2332863_2333844_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	5.36271e-61
NC_008554.1\|WP_011698773.1\|2336924_2338373_-\|hypothetical-protein	gnl\|CDD\|128563	smart00267, GGDEF, diguanylate cyclase. Diguanylate cyclase, present in a variety of bacteria.	0.00109221
NC_008554.1\|WP_011698785.1\|2353576_2355082_-\|threonine-synthase	gnl\|CDD\|107206	cd01563, Thr-synth_1, Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.	6.60474e-104
NC_008554.1\|WP_049766345.1\|2350092_2350998_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.29144e-64
NC_008554.1\|WP_011698772.1\|2335814_2336837_-\|rod-shape-determining-protein	gnl\|CDD\|237564	PRK13930, PRK13930, rod shape-determining protein MreB; Provisional.	0
NC_008554.1\|WP_011698782.1\|2351279_2352068_-\|DUF4412-domain-containing-protein	gnl\|CDD\|373032	pfam14371, DUF4412, Domain of unknown function (DUF4412). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.	2.55555e-15
NC_008554.1\|WP_011698776.1\|2341838_2342975_-\|carboxynorspermidine-decarboxylase	gnl\|CDD\|143502	cd06829, PLPDE_III_CANSDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase. Carboxynorspermidine decarboxylase (CANSDC) catalyzes the decarboxylation of carboxynorspermidine, the last step in the biosynthesis of norspermidine. It is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC), which are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. Based on this similarity, CANSDC may require homodimer formation and the presence of the PLP cofactor for its catalytic activity.	0
NC_008554.1\|WP_011698770.1\|2334626_2335298_-\|CBS-domain-containing-protein	gnl\|CDD\|341361	cd04584, CBS_pair_AcuB_like, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ACT domain. The putative Acetoin Utilization Protein (Acub) from Vibrio Cholerae contains a CBS pair domain. The acetoin utilization protein plays a role in growth and sporulation on acetoin or butanediol for use as a carbon source. Acetoin is an important physiological metabolite excreted by many microorganisms. It is used as an external energy store by a number of fermentive bacteria. Acetoin is produced by the decarboxylation of alpha-acetolactate. Once superior carbon sources are exhausted, and the culture enters stationary phase, acetoin can be utilised in order to maintain the culture density. The conversion of acetoin into acetyl-CoA or 2,3-butanediol is catalysed by the acetoin dehydrogenase complex and acetoin reductase/2,3-butanediol dehydrogenase, respectively. Acetoin utilization proteins, acetylpolyamine amidohydrolases, and histone deacetylases are members of an ancient protein superfamily.This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce acetoin as an external carbon storage compound and then later reuse it as a carbon and energy source during their stationary phase and sporulation. In addition these CBS domains are associated with a downstream ACT (aspartate kinase/chorismate mutase/TyrA) domain, which is linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.73562e-56
NC_008554.1\|WP_011698767.1\|2332154_2332760_+\|PAS-domain-containing-protein	gnl\|CDD\|214512	smart00091, PAS, PAS domain. PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.	2.83146e-07
NC_008554.1\|WP_011698777.1\|2343498_2344677_-\|saccharopine-dehydrogenase-family-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	1.39725e-162
NC_008554.1\|WP_011698778.1\|2345307_2346111_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.84393e-52
NC_008554.1\|WP_011698784.1\|2352829_2353378_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	4.57633e-82
NC_008554.1\|WP_011698774.1\|2338673_2340686_+\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0

>NC_008554.1|WP_011698776.1|2341838_2342975_-|carboxynorspermidine-decarboxylase
MTFDLSNIETPCYVVDEAALDRNLAVLDTVRQRTGCRILMALKGFAMFSLFPQIREVLAGVAASSPDEARLGFEEFRGEVHAYAPAYRESELTELLEYCDHLVFNSFSQWNRFKSRVFDHPAPVRCGIRVNPEHSEVSVPIYDPCARFSRLGVPRSAFREEDLDGISGLHFHTLCELDADSLERTLAAFETRFGAFLERMEWVNFGGGHHITRPDYDVDLLCRLIDDFRSRHPLEIYLEPGEAVALNTGILGASVLDLIHNEMDIAILDTSAAAHMPDVLEMPYRPEIDGAGMPGEYPHTYRLGGLTCLAGDVIGDYSFPEPLRIGSKLAFLDMAHYTMVKNNTFNGVRLPSIAIRDRRGNVRVVRKFGYEDYRNRLS
>NC_008554.1|WP_011698775.1|2340831_2341860_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MNDTTAKTLNCSPASRDGFPETLGDFGRTRVDLPVVLVAGPTGVGKTAFAVELARALGSEIVNADSMQVYRHMDIGTAKPTPRERSAVPHHLIDIVDPDEPFDAGDYLARARPVIATLHEAGKVPIVVGGTGLYLKVLTRGICAGAPGDPDVRRRLIEEELTLGLPALHERLRDVDPPLGARIHPNDRQRILRALEVFHHSGKPLSYWQRQHRFEDAPYRTLKIFLHRPREVLYARINDRVDAMMAQGFLDEVRNLLAMGCGPELKPMQSLGYRQMARHLRGEMSLDEAVNEIRRDTRRYAKRQLTWFRADPEYRWFDAADTHGLVARIVRETPDLHDNRLR
>NC_008554.1|WP_011698774.1|2338673_2340686_+|DNA-mismatch-repair-endonuclease-MutL
MARITILPDILCNQIAAGEVVERPAAVAKELLENSIDAGARRISLSIADGGRKEIRVVDNGSGMHPDDALLALERHATSKIRSIEDLQAIGSLGFRGEALPSIAAVSRFELVTREPDAVAGTFIRVEGGVVREVRETGSPAGTRITVRDLFYNVPARRKFLRAADTETAYICDQFQRLAMAHHAVHFQLINRERTQYDFPGAASPEERAGQVLGAETLKRAIPFCVENASARLRGMVGTPDLQRANSHSLFVFVNGRPVWDRAVNRAILAAFESLIPRGKFPVAVLFLELDPLHVDVNVHPTKREVRFKHPGGVIDTVRGAIRDALCHLRPLHGSAAAAPRPFSETADQRAFRDSLVREGQLSFDRGRPLSRPPGFPSERWRERHRPDAEPPYPLLREPAPTENPRREAGSPPAAPADSLFDEGAAPQPDNPDTDFFAEPKRAAGGPASTHAPVTVDTAAFADAFQAFEAATHLHAGDVPALAELPVIGQLANTYILLEAPDGLILIDQHAAHERIIFDALSFPAGGPARQRLIRPAVIDLPPRDAAMLRRWLPLLEEIGVEIESFGGDSFVVHAVPAPLGECPPEGLVRELLASAIEGDDAPRWNVLGRLAKTAACHRAVRAGQRLRPEEIRLLLEGLDRTRFASTCPHGRPVWYKMTLSDVARLFQRT
>NC_008554.1|WP_011698773.1|2336924_2338373_-|hypothetical-protein
MHPNPYQSLVSLLSNILEAYTTAFFVIDPKLRQLSMAASQSLSKFLPERVTLPLEQSGILSQVQKVGQTIHLDKLPDISASLASTVPFYREGESHIKGLFAVPVGDGAGVLYVDTKYGWGFNDKQQKWIREIADVLHELLLRQQQAVQRHNYSRIFELWTRLDDVAFKGHALEDYSRLVVEECCRLVGAEYGFLSLRDPASANYRLYSCTPNVPRSLISTHYVVKQGLIGRIFQTGKPLLITRLNPQASEHFLFTPAESLPHHGTLWGLPAETSLGHVLAMAFLSRQAMELNQEFEQAVSHALHFFQLLLEQLCYKEECDHLRAYDLATALYNPFSFEARLDEMLGAAMQGSTPFTLAVVQYEPWQVLYTKAAPKLIRQWQRDLAGAICGILPAEVSVGQMAENRYGIIFPETTVQEAELHLARMEDIGRQIIRTRGKGAKLHAYVATVGFPQDGTHGDELWSLAHQRLFAGFHARTEPAGT
>NC_008554.1|WP_011698772.1|2335814_2336837_-|rod-shape-determining-protein
MFERLLSYFSKDLAMDLGTANTLIYLRGRGVVLNEPSVVAINQDTHQVIAVGQEARNIIGRHSQRVVTIRPLKDGVIADFEVTAVMIKYFLSKVLKRRQFVRPRLVVAVPTGITSVEKRAVIEAAEQAGARHIHLVEEPMAAAIGTGLPVDQPFGNMIVDIGGGTTEVAVISMFAVAYSESVRVAGDEANEAILRYMQRERQMIISEVLAENIKMKIGTAAPLDQPETLEVTGKEILTGIPRTFTVTDEEIREAIKEPVYAIVEAVKRALEKTPPDLAADIHDKGFWLAGGGALLRGLDRLLSQYTTLKVNIAEDPLTAVARGAGTVIEHLDFHRSVFIN
>NC_008554.1|WP_011698771.1|2335411_2335822_+|hypothetical-protein
MRGEGNIRDQELLKKLSEAIEEWEISPYFLPADELFDLERFLADHDADQTRGELEAIYGTPLNYNFWSSFLAFHRLKRAREETRVQDALREEKRRQYLMVVEEEKRAGKKWLKEWFHNQRRRQIRILPGGRGGKPS
>NC_008554.1|WP_011698770.1|2334626_2335298_-|CBS-domain-containing-protein
MYVGWYMKTKLLTITPETSVFKAREMMDNHRISHLPVTDGKAHLVGLVTDRDLRQVWASPATTLSVHELTYVLQKLTVANVMTRNVVTATPDMHIERAALIIHDKKFGALPVVKDDRLVGIITVTDLMQVVLTALGLSDNTKRLSLLAVDRIGLLAEVCNYMAQAGINISSVLFVPLVAHPDVWQVILRVNTDVYDKAVSILTEAGYKVITQYVEDLTAYLPR
>NC_008554.1|WP_150109473.1|2333899_2334502_-|hypothetical-protein
MADIIQFKDRGGGRGDNVIVRRPLEFRRGEWRSGFVMMCTREESGRFEAHREDALRAEGHRHVAFVPDHITLDGGLHFTVMGLYRHRDDEASMRRVYRLAAMMECVTKEPSPILRTDLLRRFYKTITEERDALRVIWRGSVQDFLLPVHPVWYDLQRFGRRVAGAGSLKALYDVIREESDAQFDVLSLHYVFYLPESFVG
>NC_008554.1|WP_011698768.1|2332863_2333844_-|ROK-family-protein
MTEDLVIGIDVGGTNMRSALVDPRGRIVLQSRTATGAWLEGRETARRLIEECRSLRLAASGFGAAVRAAGLGVAGRIDPREGRVVFSPNLPRMNGYPLAAELRTALDLPVVMLNDADCFGIGESRLGAGRSIPNWVGLTLGTGVGGCLVLDNHLWTGDNLGFAGEIGHMIVVPGGRPCACGARGCLEAYASGRALVEGFLEAAATGAPVAGIEQRPLEPAKVAARDVHRLALQGDPLAREVFRRMGWAIGLALSNCFTVLGVRHAVIGGGVSAGWDQFEGALVVSLAEHATMFEAADAVIRRGVLGDDAAPLGAALAAWRQLGHGA
>NC_008554.1|WP_011698767.1|2332154_2332760_+|PAS-domain-containing-protein
MILRGLLETDSFVGGILNAMPLPVFVVDDDMGIIAYNQSASQLLGSDPETVIRRRTGELLHCVHSYETQEGCGRAPLCRDCILRNAVGECLREGKAIRRKALMEVAPKSAPARTIDLFVTAAPFKYQAGGYALLVLQDVTELVELRSIVPICSYCKKIRNDAQYWDSVELYIKTHIDVQFSHGICPECFEKVRLDRPEKDP
>NC_008554.1|WP_011698777.1|2343498_2344677_-|saccharopine-dehydrogenase-family-protein
MSKVLIIGAGGVGGVVTHKCAQVPEVFSEITLASRTLSKCERIRDQIARPIRVERVDADNVPELVALIRAVKPDVIINVALPYQDLSIMEACLETGVDYLDTANYEPPDEARFCYKWQWDYHDRFREKGLMALLGCGFDPGVTNIYCAHALQKHFDAVHAIDIMDCNAGEHGHPFATNFNPEINIREVTARGKYWENGQWLETEPLCVHETFDFPEIGPREMYLMYHEELESLVKHIPGLRRIRFWMTFGQEYLTHLRVLQNVGMTRIDPVSFQGCRIVPLQFLKALLPEPSSLGANYRGKTCIGCMITGTKEGKPRKYFIYNVCDHAEAYREVKAQAISYTTGVPAMLGAQLMLTGKWRGRGVFNVEQFDPSPFMERIGGYGLPWTEKFLE
>NC_008554.1|WP_011698778.1|2345307_2346111_+|SDR-family-oxidoreductase
MKTFYANKVAVVTGGASGIGLAMTELMLGFGAVVIMADINETGLNAESARLEEQYPGKVFARKTDIGKADEVKALVDHAVEKGGRLDLMFNNAGLGLTKPIDQITMDDWKFAFDVNFYGALYGTLEARRVMRAQGGGGHIANTASGIAFAPMPLQAMYSATKAALHALTLSLRAECWDENIFLHSVIPGTVATPIFAGSRVPKGALKPEESARVILEKVKDNMRIVFVTSSDMDGAKNCNHPDLQPFMDDYFNHIAAARKAGNYTAM
>NC_008554.1|WP_150109635.1|2346341_2347523_+|hypothetical-protein
MVLFGLLLFKIHTGELPYNPDGTYGLFLVIVSFQTITMGKTPFGDLRRSRALIMTGICTAVLGMTACFIPGTLTGLVRMLVGTVLLAGGTVLLAQLFFSEEKARTWMRIAGILRQLTVACGVVYAMTVVQGLITLFPGFTTDRQTAVLLIGYGAGFFYLSWCIRKAAQAYPPEDSPDGASSAPNPDNAGSTRCFGLFRDASLSLMPAILILLGILLTLLGLLLFPVNIGLLPFSPDGQLGVLLTLTAIQMMALGDTPLGRYRRSSLMILTGLVFAALGIVSCIVPGMLTGMIQTFLGLVNIIGGASALVRRYAPMPHASRAPAAAPSPVPPTVRKLMLTQTVLNLVTMVFGVSMLVPSLVSGLVVAGILVVNGLLLFALASLLQELTRMQASG
>NC_008554.1|WP_011698780.1|2347823_2350190_+|hypothetical-protein
MERSHWMDNSRREIMNEYLQFKRTIQTRVEILEEAIQEADSHGMIESAAVARWHKHLALVKSSLQDTLLRIAVVGSVKSGKSTLINALAEHDLLKRGAGIVTAFITRVLSDNDVGGWIELKTWEQALDELNAVVRAMPAFQEEDAGGKPLDIRVEEDREKLRLLVEKTRVEWLQRKGSLDAGFIILKGFLDGYGSLASSIGEQVNRLILDRDSLHRHQRYVGHEGPAVYVRDVELHYPFPWLGEKVEIADCQGSDSPNPLHFELLQQYLLGSHFILYVISSRTGLREADFKLIDFIKTLRMFPQTTFVLNVDLDVHTSEEELQGQFDRVRSELEWVVPNPRLFSFSALHQLVGQLGANAPEKERRRMELWREDRKLAEASENGFASFREHLERRIGGQRARILLGSGLSRLSMVAGSVLDTARVHRQYIARSPSAIQDAARQLENRRPALRGTLVTLANAISGLNDSLRREVGDTVDRYFDPAHGRIVRETLEMVEHFAIDAHTREELGDHRQVLRQLYRFYIEFRQSLSRYLVERVNLRVIEFAKTEEASLKDRLNRSCRAFWTLFAVAVAEYRRDFAQAPTPSGAADEPVEYDWPDDVKIVPPAFSAFLDREAIGRGVLLMKFGLGRFARFIGSLRTHVSRHQDLLKAEPQREETVAEAIRLVKAEAGAELLRAFQHYRDTFKTVFLFRMLDEATLHLLEEFRTRAEMAQMDLADLLERREAEGAGLQLKMDAIDRCAAIAEAMVEELDELRCAVNPECPLPEVPASTPEQERSEPAPNRASDEGA
>NC_008554.1|WP_049766345.1|2350092_2350998_-|RluA-family-pseudouridine-synthase
MDFRIPDTDRWTADPALKGTGLARLIARYLLISEDRAEDLIDFGSVYIDGRVERNPARTLRGGEEIVVNWPRHGTQRHYEIDPARILYRDAHLLAYDKEAGVPSQQTPADAYNNLYAALIRFLAGEARASAPYVALHHRLDRETSGVMVFALDRAVNRRLGESFQEKRVVKDYLAWVDGVPVLDRWTAVEDICRKDGRYRTCPQGRGKAARTLLRVLLRAGDRALIAARPVTGRTHQIRLHLAACGHPVIGDRLYGGTSGERLHLHALRLRLPHPKHDSELVLSAPVPEYWPEPRAVDIPD
>NC_008554.1|WP_011698782.1|2351279_2352068_-|DUF4412-domain-containing-protein
MFHRQWRVSAPLVVLIVLFAASTAFCDLSWESEKVTDNVPGQEDGTTIQKNYYTSHASRVEMGDGTVMIMDFQKMMMYRLNAQERTYSEVNLSEMGVPRDVPAEDRERMKKMMGDLMMSFSVTPTDETKTIEGYKCRKYLVSFMRVNSEYWLSKDVNGYDELKKIGAGLSKYYRQNPMLQQLDITGMMDKLDGFPVMTKTEIMEGSMTTVLKKVDVKTLSPDLFTVPAGYTLQKAESQQQGQGRMPPSQPPQSSQPQPRRGY
>NC_008554.1|WP_049766346.1|2352406_2352679_+|hypothetical-protein
MNMDRAIFELNASVEATSLYILICALMDQGEPPSLNSARERWNGTTESLHAAAAELLRLGVLEVVPPFTPDKHLHISPSTNWCPSRQSVS
>NC_008554.1|WP_011698784.1|2352829_2353378_-|gamma-carbonic-anhydrase-family-protein
MGVLPYRNVMPRLAEDVFVAPGAWVIGNVEIAARSSVWFNTVIRGDVHTIRIGSETNIQDNCSLHVTEPDFPLEIGNRVTVGHRAIVHGCVVEDDCLIGMGVIILDGAKIGRGSVIAAGALITPGFVVPPKSLVMGSPAQVKRPITDEEFQRAQKSYFHYIDLASDYRDPGREGIRIKGFLG
>NC_008554.1|WP_011698785.1|2353576_2355082_-|threonine-synthase
MKIDQFPEHIRPYLVPRAGGEYAYECFSCGREHGIERLLYTCPDCGSVLMIKDLEWSRLKRIPGSLWREIFDYRSMLTLPALRGIYRYHELIGSVIPPESVVWLGEGYTPVVAANAVLCDWAGCAFFFKNDGQNPSASFKDRGMASAFSYLNYLIGHRGMEDVLAICASTGDTSASAALYGSYFVHGVKSAVLLPHGKVTPQQLGQPLGSGARVIEIPGVFDDCMKVVEYLSEHYSVALMNSKNAWRILGQESYSYEIAQAFDYEIGDLAVFVPIGNAGNITAVLQGFLKLHDLGIIPALPAVFGVQSEHANPVYLYYLEPEREKRRFRPVTVRPSVAQAAMIGNPVSMPRVVKLVEEYRLRAGEDAVRVVEVSEQEIMDAMLTANRNGHIVCTQGGECLAGCRKAVASGMQAAGRRAVLDATAHALKFSVFQDKYFSDSFEPEYEVVPKAELRNAPVLVSPPDGVPKPVPGREMPPEDFRRFLAFASGAVAELLGLKRKQ
>NC_008554.1|WP_167321333.1|2355456_2356404_+|UDP-3-O-acyl-N-acetylglucosamine-deacetylase
MKFFYPRQHTVTREVWCGGVGLHTGADVTIRLKPAPPDFGIRFQRTDLTGKPVITAHYRQVVDTFQATTIGIAGAVVGTVEHLMAAFYGCGVDNVLVEVDGPEIPILDGSAAPYTGLIRKAGVREQDAVRRCLIVDRPMVVKEDGAYIRVTPSDHFRIDCAIDFPHPLVGKQRYSWSFCENSFKREIAKARTFGFLKDVRKLQTMGRAQGGSLANAIVLDECGLLNREGFRYADECVRHKLLDFMGDLALIGMPVVGAFHVHRAGHSLHSRFLKQLMTRPGTCSLAQPSCIPTGVFPASRLPAFAGQISSVAKPI

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Crispr_ID: NC_008554_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_14

2360987-2361184

Orphan

Consensus_repeat	Method
CCCCGGGCGAAGGGACAAT	CRT
CTCCCCGGGCGAAGGGACAATCC	PILER-CR

3 spacers

The CRISPR arrays of NC_008554_14

>merge|NC_008554|14|2360987-2361184|CRT,PILER-CR
CGGCGCGGGAAGGGACCGGAAACGGGTTGGAGAAGCAGACCCCGGGAGGAGTGTTCCCCGGGCGAAGGGACAATCCGCAACGGGCCGCAGCTGTCGATGAAATCGGACAGAACACCCCCCGGGCGAAGGGACAATCCAACTGAAGGCGTGCCCCCTCTGCATTCGTCATCGGAATCTCCCCGGGCGAAGGGACAATTC

>NC_008554|14|2|2360987-2361182|CRT
CGGCGCGGGAAGGGACCGG	AAACGGGTTGGAGAAGCAGACCCCGGGAGGAGTGTT
CCCCGGGCGAAGGGACAAT	CCGCAACGGGCCGCAGCTGTCGATGAAATCGGACAGAACACC
CCCCGGGCGAAGGGACAAT	CCAACTGAAGGCGTGCCCCCTCTGCATTCGTCATCGGAATCT
CCCCGGGCGAAGGGACAAT

>NC_008554|14|2|2361041-2361184|PILER-CR
TCCCCGGGCGAAGGGACAATCCG	CAACGGGCCGCAGCTGTCGATGAAATCGGACAGAACAC
CCCCCGGGCGAAGGGACAATCCA	ACTGAAGGCGTGCCCCCTCTGCATTCGTCATCGGAATC
TCCCCGGGCGAAGGGACAATTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011698780.1\|2347823_2350190_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366045
NC_008554.1\|WP_011698793.1\|2367259_2367604_-\|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl\|CDD\|180218
NC_008554.1\|WP_011698791.1\|2363837_2365319_-\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235622
NC_008554.1\|WP_011698789.1\|2359542_2360973_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_008554.1\|WP_011698785.1\|2353576_2355082_-\|threonine-synthase	unknown	unknown	gnl\|CDD\|107206
NC_008554.1\|WP_011698795.1\|2368234_2368771_-\|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl\|CDD\|235637
NC_008554.1\|WP_011698787.1\|2356676_2357249_+\|DUF4390-domain-containing-protein	unknown	unknown	gnl\|CDD\|373018
NC_008554.1\|WP_011698798.1\|2372405_2372816_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|376344
NC_008554.1\|WP_150109636.1\|2365349_2367239_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NC_008554.1\|WP_049766345.1\|2350092_2350998_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_008554.1\|WP_011698794.1\|2367600_2368119_-\|NADH-ubiquinone/plastoquinone-oxidoreductase-subunit-6	unknown	unknown	gnl\|CDD\|235844
NC_008554.1\|WP_011698782.1\|2351279_2352068_-\|DUF4412-domain-containing-protein	unknown	unknown	gnl\|CDD\|373032
NC_008554.1\|WP_011698790.1\|2362422_2363841_-\|NADH-quinone-oxidoreductase-subunit-N	unknown	unknown	gnl\|CDD\|235603
NC_008554.1\|WP_041440261.1\|2373549_2373870_-\|IS1182-family-transposase	unknown	unknown	gnl\|CDD\|226192
NC_008554.1\|WP_011698788.1\|2357258_2359484_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|227333
NC_008554.1\|WP_167321333.1\|2355456_2356404_+\|UDP-3-O-acyl-N-acetylglucosamine-deacetylase	unknown	unknown	gnl\|CDD\|237294
NC_008554.1\|WP_049766346.1\|2352406_2352679_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698796.1\|2369010_2370006_-\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|376297
NC_008554.1\|WP_011698784.1\|2352829_2353378_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NC_008554.1\|WP_011698797.1\|2370045_2372409_-\|NADH-quinone-oxidoreductase-subunit-B/C/D	unknown	unknown	gnl\|CDD\|183955

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698780.1\|2347823_2350190_+\|hypothetical-protein	gnl\|CDD\|366045	pfam00350, Dynamin_N, Dynamin family.	7.50827e-10
NC_008554.1\|WP_011698791.1\|2363837_2365319_-\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	3.24202e-135
NC_008554.1\|WP_011698789.1\|2359542_2360973_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_008554.1\|WP_011698785.1\|2353576_2355082_-\|threonine-synthase	gnl\|CDD\|107206	cd01563, Thr-synth_1, Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.	6.60474e-104
NC_008554.1\|WP_011698795.1\|2368234_2368771_-\|NADH-quinone-oxidoreductase-subunit-NuoI	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	1.18093e-66
NC_008554.1\|WP_011698787.1\|2356676_2357249_+\|DUF4390-domain-containing-protein	gnl\|CDD\|373018	pfam14334, DUF4390, Domain of unknown function (DUF4390). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 192 and 203 amino acids in length.	6.90966e-38
NC_008554.1\|WP_011698798.1\|2372405_2372816_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|376344	pfam00507, Oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.	3.30363e-40
NC_008554.1\|WP_150109636.1\|2365349_2367239_-\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	3.24034e-169
NC_008554.1\|WP_049766345.1\|2350092_2350998_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.29144e-64
NC_008554.1\|WP_011698794.1\|2367600_2368119_-\|NADH-ubiquinone/plastoquinone-oxidoreductase-subunit-6	gnl\|CDD\|235844	PRK06638, PRK06638, NADH-quinone oxidoreductase subunit J.	6.84304e-29
NC_008554.1\|WP_011698782.1\|2351279_2352068_-\|DUF4412-domain-containing-protein	gnl\|CDD\|373032	pfam14371, DUF4412, Domain of unknown function (DUF4412). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.	2.55555e-15
NC_008554.1\|WP_011698790.1\|2362422_2363841_-\|NADH-quinone-oxidoreductase-subunit-N	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	4.56159e-118
NC_008554.1\|WP_041440261.1\|2373549_2373870_-\|IS1182-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.93742e-11
NC_008554.1\|WP_011698788.1\|2357258_2359484_+\|HAMP-domain-containing-protein	gnl\|CDD\|227333	COG5000, NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms].	2.16482e-128
NC_008554.1\|WP_167321333.1\|2355456_2356404_+\|UDP-3-O-acyl-N-acetylglucosamine-deacetylase	gnl\|CDD\|237294	PRK13186, lpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase.	3.31123e-157
NC_008554.1\|WP_011698793.1\|2367259_2367604_-\|NADH-quinone-oxidoreductase-subunit-NuoK	gnl\|CDD\|180218	PRK05715, PRK05715, NADH-quinone oxidoreductase subunit NuoK.	2.22701e-27
NC_008554.1\|WP_011698796.1\|2369010_2370006_-\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|376297	pfam00146, NADHdh, NADH dehydrogenase.	3.03997e-140
NC_008554.1\|WP_011698784.1\|2352829_2353378_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	4.57633e-82
NC_008554.1\|WP_011698797.1\|2370045_2372409_-\|NADH-quinone-oxidoreductase-subunit-B/C/D	gnl\|CDD\|183955	PRK13292, PRK13292, NADH-quinone oxidoreductase subunit B/C/D.	0

>NC_008554.1|WP_011698789.1|2359542_2360973_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MKPKILVVDDEISILQSLRGVLQDEGYRIGVAASGEEALEELRRDTPDLMLLDIWMPGMDGLAVLEEIKKSHAHLPVIIISGHGNIETAVKATRMGAFDFVEKPLSLERILVSIKNALDFHRLEEENLLWRQKAHRTSHMTGRSEAVESLREQIRRAAPTNATVLITGENGTGKELAARMIHQLSKRSHRPMVEVNCAAIPEDLIESELFGHEKGAFTGAHERRRGRFDVANGGTLFLDEIGDMSLRTQAKILRILQEQVFERVGGSRTIQVDVRVVAATNKDIQREIEAGRFRQDLYYRLNVIPIFVPPLRDRLQDIPLLVEDFLDDMAAESAMGRKEIDPAVFGPLQQYSWPGNIRELRNFIERMVIMTPGQRIGPRDLPLDFLNRLPKPPEEAGPYQCATLREARSVFERAYLLRKLDEFAWNVSLTAAQVGLERSHLHRKMKALGIREREETLDAHESPPNDAEARKRGTGE
>NC_008554.1|WP_011698788.1|2357258_2359484_+|HAMP-domain-containing-protein
MNSSQGPPDKTSRRRTRERILVIAVFAAIITVGFFEGWFFRLQSDLPLSGNILLFAFININVILLLLLAYLVLRNIVKLVFERKRNILGHKLRTRLVIASVGLTLIPTIPLFWLATQFIFSSLDQWFSYQVEQSLEQAVGLGKNVLEREGADLVTDARSIKAEVLKLDEEERPAPAALERISSSYMGQYRIDGLFLFDGSGRLTWKTVSPELGEIEPGALRKLLEKESEQTARSYTLSSEAKREGLAAHVFFPRGSGPTGEGSELIAFRLLPPHIMEKLGTITGGYEDYLQLKLLHFPLKQSHFITFSIVTLLTIFAAIWFGFFIARSLTVPIQALVSATQRIAEGDLEVHLESQRQDELGMLITSFNDMVEDLRESRGKLANAYLALQQSHLELENRRRYMEVVLKNIAAGVVSVDAGGRIMTMNKAAEETFGLHADRVKGLHYSSFLRPAHLEIVKSFTEMYESTRQPYLEQQVQVVVGEQPMTLLINASVLKDEKNEFMGVVAVLDDLTELEKAQRMAAWREVARRIAHEIKNPLTPIQLSAQRLRRKHPELLEEADSVFDECTRTIIQQVDHMKHLVNEFSKFARLPRARPVPSDLCAIIEESLALYRHTYPNISFVLEKMDDLPPLRLDRDQFRQVMINLIENAVYAIGREKGVITNRVSYDPVLNIARMECADTGRGISPEGKLRMFEPYYSTRRKGTGLGLAIVASIIADHNGFVRVRDNVPAGTVIVIELPGR
>NC_008554.1|WP_011698787.1|2356676_2357249_+|DUF4390-domain-containing-protein
MIYFKSIARCGTLLAILLLWCALPVSAANRAQIVDIALNRDRGNLQVSLRIKDCFTPKMEEAIKTGVLTTFRILVVFEQGNLPFRSRIVDTAIEHTIKYDLLKNEYHVQVPEHPDRILRTRDFEQAKRWMSTVSRYSLIPLQRLEEGQTYELRLKAELSKFQLPLFFRYIFFFVSLWDFETDWQKVDFTL
>NC_008554.1|WP_167321333.1|2355456_2356404_+|UDP-3-O-acyl-N-acetylglucosamine-deacetylase
MKFFYPRQHTVTREVWCGGVGLHTGADVTIRLKPAPPDFGIRFQRTDLTGKPVITAHYRQVVDTFQATTIGIAGAVVGTVEHLMAAFYGCGVDNVLVEVDGPEIPILDGSAAPYTGLIRKAGVREQDAVRRCLIVDRPMVVKEDGAYIRVTPSDHFRIDCAIDFPHPLVGKQRYSWSFCENSFKREIAKARTFGFLKDVRKLQTMGRAQGGSLANAIVLDECGLLNREGFRYADECVRHKLLDFMGDLALIGMPVVGAFHVHRAGHSLHSRFLKQLMTRPGTCSLAQPSCIPTGVFPASRLPAFAGQISSVAKPI
>NC_008554.1|WP_011698785.1|2353576_2355082_-|threonine-synthase
MKIDQFPEHIRPYLVPRAGGEYAYECFSCGREHGIERLLYTCPDCGSVLMIKDLEWSRLKRIPGSLWREIFDYRSMLTLPALRGIYRYHELIGSVIPPESVVWLGEGYTPVVAANAVLCDWAGCAFFFKNDGQNPSASFKDRGMASAFSYLNYLIGHRGMEDVLAICASTGDTSASAALYGSYFVHGVKSAVLLPHGKVTPQQLGQPLGSGARVIEIPGVFDDCMKVVEYLSEHYSVALMNSKNAWRILGQESYSYEIAQAFDYEIGDLAVFVPIGNAGNITAVLQGFLKLHDLGIIPALPAVFGVQSEHANPVYLYYLEPEREKRRFRPVTVRPSVAQAAMIGNPVSMPRVVKLVEEYRLRAGEDAVRVVEVSEQEIMDAMLTANRNGHIVCTQGGECLAGCRKAVASGMQAAGRRAVLDATAHALKFSVFQDKYFSDSFEPEYEVVPKAELRNAPVLVSPPDGVPKPVPGREMPPEDFRRFLAFASGAVAELLGLKRKQ
>NC_008554.1|WP_011698784.1|2352829_2353378_-|gamma-carbonic-anhydrase-family-protein
MGVLPYRNVMPRLAEDVFVAPGAWVIGNVEIAARSSVWFNTVIRGDVHTIRIGSETNIQDNCSLHVTEPDFPLEIGNRVTVGHRAIVHGCVVEDDCLIGMGVIILDGAKIGRGSVIAAGALITPGFVVPPKSLVMGSPAQVKRPITDEEFQRAQKSYFHYIDLASDYRDPGREGIRIKGFLG
>NC_008554.1|WP_049766346.1|2352406_2352679_+|hypothetical-protein
MNMDRAIFELNASVEATSLYILICALMDQGEPPSLNSARERWNGTTESLHAAAAELLRLGVLEVVPPFTPDKHLHISPSTNWCPSRQSVS
>NC_008554.1|WP_011698782.1|2351279_2352068_-|DUF4412-domain-containing-protein
MFHRQWRVSAPLVVLIVLFAASTAFCDLSWESEKVTDNVPGQEDGTTIQKNYYTSHASRVEMGDGTVMIMDFQKMMMYRLNAQERTYSEVNLSEMGVPRDVPAEDRERMKKMMGDLMMSFSVTPTDETKTIEGYKCRKYLVSFMRVNSEYWLSKDVNGYDELKKIGAGLSKYYRQNPMLQQLDITGMMDKLDGFPVMTKTEIMEGSMTTVLKKVDVKTLSPDLFTVPAGYTLQKAESQQQGQGRMPPSQPPQSSQPQPRRGY
>NC_008554.1|WP_049766345.1|2350092_2350998_-|RluA-family-pseudouridine-synthase
MDFRIPDTDRWTADPALKGTGLARLIARYLLISEDRAEDLIDFGSVYIDGRVERNPARTLRGGEEIVVNWPRHGTQRHYEIDPARILYRDAHLLAYDKEAGVPSQQTPADAYNNLYAALIRFLAGEARASAPYVALHHRLDRETSGVMVFALDRAVNRRLGESFQEKRVVKDYLAWVDGVPVLDRWTAVEDICRKDGRYRTCPQGRGKAARTLLRVLLRAGDRALIAARPVTGRTHQIRLHLAACGHPVIGDRLYGGTSGERLHLHALRLRLPHPKHDSELVLSAPVPEYWPEPRAVDIPD
>NC_008554.1|WP_011698780.1|2347823_2350190_+|hypothetical-protein
MERSHWMDNSRREIMNEYLQFKRTIQTRVEILEEAIQEADSHGMIESAAVARWHKHLALVKSSLQDTLLRIAVVGSVKSGKSTLINALAEHDLLKRGAGIVTAFITRVLSDNDVGGWIELKTWEQALDELNAVVRAMPAFQEEDAGGKPLDIRVEEDREKLRLLVEKTRVEWLQRKGSLDAGFIILKGFLDGYGSLASSIGEQVNRLILDRDSLHRHQRYVGHEGPAVYVRDVELHYPFPWLGEKVEIADCQGSDSPNPLHFELLQQYLLGSHFILYVISSRTGLREADFKLIDFIKTLRMFPQTTFVLNVDLDVHTSEEELQGQFDRVRSELEWVVPNPRLFSFSALHQLVGQLGANAPEKERRRMELWREDRKLAEASENGFASFREHLERRIGGQRARILLGSGLSRLSMVAGSVLDTARVHRQYIARSPSAIQDAARQLENRRPALRGTLVTLANAISGLNDSLRREVGDTVDRYFDPAHGRIVRETLEMVEHFAIDAHTREELGDHRQVLRQLYRFYIEFRQSLSRYLVERVNLRVIEFAKTEEASLKDRLNRSCRAFWTLFAVAVAEYRRDFAQAPTPSGAADEPVEYDWPDDVKIVPPAFSAFLDREAIGRGVLLMKFGLGRFARFIGSLRTHVSRHQDLLKAEPQREETVAEAIRLVKAEAGAELLRAFQHYRDTFKTVFLFRMLDEATLHLLEEFRTRAEMAQMDLADLLERREAEGAGLQLKMDAIDRCAAIAEAMVEELDELRCAVNPECPLPEVPASTPEQERSEPAPNRASDEGA
>NC_008554.1|WP_011698790.1|2362422_2363841_-|NADH-quinone-oxidoreductase-subunit-N
MNWMSFAPELITLTSALWFLLLSMTARSDPKREHVAALVLSALGLAACLASVGAEGYCFAGAYKVDLFSQVFKVLLAAGLFLIVTLCGELSDIEERNRREFYVLLFVCTLAMMLLVGANHFLVVFISLELSSYSLYVLVALRRDRGLGLEAGIKYFLVGIFASGVMIFGLALLYGASGIAALDGMARVLPGIIHQPAVVIGLLLTLSGFFFKLAVFPFHFWAPDAYQGAANQVSAYIATASKVAAIGVLVRVIASAGDGGTYLVHVLAVLSVVSMTVGNLAAIAQQDLKRLLAYSTVAHAGYVLIGVLSMNPAGYSAAVFYAFALLVMKFTAFLVLVEVASDGGNLRVEELAGLHRRSPILALALMVSLFSLAGIPPTVGFTGKFLVFVAAMGEGHFTLVLIAMINVVISLYYYLLVIKAAYLLEPRQELPALRVSPPLKLLSGVLVIAMVAAGFFPNQIIRVAESAAKALL
>NC_008554.1|WP_011698791.1|2363837_2365319_-|NADH-quinone-oxidoreductase-subunit-M
MQIADAGFPYLSAILVSCLAGLLLIVAIPEERKALIRRVSAVFSGITLVLSVIVFCAYDKSQGGLQFVEKVMWIPSLGIQYFNAADGFNLPNLLLTGIVFFTGVLTMWELETRVKEYYALYFLLVLGVFGLFMSMDLFFIFVWYDVSLFPMYLLIAVWGHTRKEYGAMKLTLYLLAGSALILPAIVYLFTRSGLNTFDVVALMQPGVFSADVQKFAFPLLYLGFGILAGVWPFHTWSPVGHVAAPTGVSMVHAGVLMKIGAFGILRVGIFLCPLGWQYWAQLMALLAAVGIIYGALVGLRQTDLKYVIGYSSVSHMGVVGLGLSTVSVDGLNGAVFQMFSHGIMTALLFSSVGYIYDRTHTKMIPELGGLSRIMPVASAYFILAALAGMGVPGLANFWGELVVFIAAVKVYPVRGIVAVLALVVTALFMLRVVQKTFYGPENERHAHLPDVSFGLGVPRMILAFVLVLFGLYPALMFDVIQTASIPFMNGLPK
>NC_008554.1|WP_150109636.1|2365349_2367239_-|NADH-quinone-oxidoreductase-subunit-L
MTLTTAVLTTVAPFVSFVLIMLLTRSRPRLSAGLSIGAVTVSLVGAVVLLCLHWHTGKPVQYTTRWMISGDTGIPVGYLLDPVSLLMLLVVAAVSFLIQVYSLGYMAGDTGFSRYFAFMSLFVWAMMCLVIAPTLFQLYVFWELVGLSSYLLIGFWYRKFSASQAGKKAFVMTRAGDVALFIGMLLVLLHLGNLNILEIDGPEMAQRMPPNLLTLSAVLIFGGIIGKSAQFPLMTWLPDAMEGPAPVSALLHSSTMVAAGVYLFERLFPFFLLSPVAMTVGLTIGTVSMLLASTMAMVSRDIKQIWAYSTISQLGFMIMGLDAGSLFSGVFHLTTHAGFKALLFLCAGVFIHRHQTNDIFELSRLGVRSLKAPMVCTVIAVGSLAGLPPLSGFFSKEVILAGLGDLANPMWLTAALLGVFLTAYYGFRLVFILLFPREPAERAGQNEGDRGSEAEHGHGGTAHWLMTWPLILLAAATVLLGFLEKPLERFLLGGSAPPGIHSSGYLALVPYIALALALAGIGLAWVEFGRRSAPRVGFVERVPALHRLFAERWYIDHFYRLALDRLIDRGIARLFQDNDDKVIDGGIDGVCRGTVFGGRLASALQSGMIQYRLLATFVVMVMLAVYFFL
>NC_008554.1|WP_011698793.1|2367259_2367604_-|NADH-quinone-oxidoreductase-subunit-NuoK
MIVPFGHVLLLAGALFGLGVFCAVARRNLIMIVLGVEIMLNAASIAFIGAAARWQSMEGQAFVLFILAVAATEVSIGLAIIVYAFRRTGSFDPAAYNLMKAGDAMQSFERRGPQ
>NC_008554.1|WP_011698794.1|2367600_2368119_-|NADH-ubiquinone/plastoquinone-oxidoreductase-subunit-6
MTLYAFLFYIVAGITVASTAMAITRRNLVHAVIYLIFSYFGTAVLFYLFGAPLLAAFEVIIYAGAIMVLFLFIVMMIRIESYGELMFPPGQWLPAAVFGLVYLVVGILMISATPGTEIPLQTVLATPREFARYVFQNHWLSVEIVSLLLLVALVGALHLGRHKGRNEVEEVE
>NC_008554.1|WP_011698795.1|2368234_2368771_-|NADH-quinone-oxidoreductase-subunit-NuoI
MSSAWEAVRALASGFATTFVHLFRKPVTEEYPEVKRALPARTRAVIVLTRDPDGGERCVACYLCSAVCPVSCISMQAAEREDGRRHAAWFRINFARCIYCGLCEEACPTSAIQLTPFFETCERDILKLVYEKEDLLVDHQGKDKEYNFYKYAGVTTDVGGKGEHVQEDEPVDLRSNLP
>NC_008554.1|WP_011698796.1|2369010_2370006_-|NADH-quinone-oxidoreductase-subunit-NuoH
MLNWTAGFLVLIAKLTIVLAVLLLVAAYLVWLERKFLARLQIRYGPNRAGKFGLLQPIADIVKMVAKEDTVPEGAERTIFMLAPAVVAATALLVFAVIPFGKDVTLWGMKIPLVVADLNVGLLYFFALSSLGVYGVALGGWASNSKYSLLGGIRGAAQMISYELSLGLAIVPVVMQARSFSLVDIVQAQEKYPFILTQPVAFAIFVISAMAEIKRIPFDLPEAENELGAGFHTEYSGMRFGLFFLGEYVNMQVLGGLVAVLFLGGWHGPLLPPVVWLFIKIVLVALIMIWVRGTLPRLRYDQLMALGWKVLIPLALVNIMVTGAWVLWMGK
>NC_008554.1|WP_011698797.1|2370045_2372409_-|NADH-quinone-oxidoreductase-subunit-B/C/D
MSDRFLSAADFVLNWSRKYSLWPLFFGLSCCFVEEATAFTPRYDMARFGAEVLRPSPRQADLLIVSGTVFKKIAPVVLRLYEQMAEPKWVISMGSCSNCGGMYDVYSVVQGIDQILPVDVYIPGCPPRPEAVLQGLTLLQKKIAAEERPARSVLHLPGGSQGSTRPVLVDGATKSRDPRGPGMEGTVIRGTANTPPAFTGSRSDLMWTPPARRIESSEREKELARVLSERFGDAVREEPFTSDMPTFHVETNRLKDVLGFLKKEASPRFLRLDDLTAVDESARRDRSAYPDWTMVYHLLSFEPAGRVRLKTGLHGRQPALPSITDIWPSANWYEREVYDLFGIRFEGHPNLRRIMMPHDWEGHPLRKDYPGRATQMAPYTLGDARVHQPPDGGIFTKDPGGDRLVLNIGPSHVSTHGLLRYVVSLDGEEISDLELEIGYHHRGVEKIGERQTWHQFIPYCARVDYLAGAANDLPYVMAVETLADIKVPERAQVIRVLLSELFRLSNHLVWFATYAHDVGAMTPNFYTFTEREMILDIVELITGGRLHPSWFRLGGVAADLPEGWKEAVDALVRIFPGRLREYESLIRKNPIFKARTQGVGRISREDAVDWGVSGPNLRACGLEWDLRRKFPYSGYENFEFEVPTAVEGDCYARYLVRVEEMRQSLRIIEQAAANMPSGRHVTDDYRYVIPDRRDTLKNIESLIHHFVNVTRGPRIPKGEAYVSCEIPRGEQGYYVVGDGLGYAYRMRIRGPGFANVQVMPLLARGESIADLIAIIGSVDYILPDIDR
>NC_008554.1|WP_011698798.1|2372405_2372816_-|NADH-quinone-oxidoreductase-subunit-A
MQPISPDGSLSPWEPGMFSLAVYAVLVAAFVAVQLFVAWWLGERKPGVEKARPYECGIIPTGSARLRYPVPFYLVAIFFLIFDMEGAYILTWAVAFEELGWAGWLQMSFFIGLLLVGLVYVWKKGGLDWRPSYGKK
>NC_008554.1|WP_041440261.1|2373549_2373870_-|IS1182-family-transposase
MEKMFKSCDRKQLLLLPPSLLDWLPEGHLAHFILDVVEQLDLSELYASYKGDGRGQPPYEPGMMTALLFYAYCTGFPSSRQIEKRTHEDVAFRVIAANRHPDHDSI

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Crispr_ID: NC_008554_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_15

2384314-2384394

Orphan

Consensus_repeat	Method
CGACGTTCCCGTGGAACGTCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_15

>merge|NC_008554|15|2384314-2384394|CRISPRCasFinder
CGACGTTCCCGTGGAACGTCCCTCGTCTTTGGCTATTTGATTGCATAACAAACGGCAGCGACGTTCCCGTGGAACGTCCGC

>NC_008554|15|14|2384314-2384394|CRISPRCasFinder
CGACGTTCCCGTGGAACGTCCCT	CGTCTTTGGCTATTTGATTGCATAACAAACGGCAG
CGACGTTCCCGTGGAACGTCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011698807.1\|2386132_2388031_-\|phosphoglucose-isomerase	unknown	unknown	gnl\|CDD\|236551
NC_008554.1\|WP_041440261.1\|2373549_2373870_-\|IS1182-family-transposase	unknown	unknown	gnl\|CDD\|226192
NC_008554.1\|WP_041440272.1\|2385383_2386070_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|238244
NC_008554.1\|WP_011698795.1\|2368234_2368771_-\|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl\|CDD\|235637
NC_008554.1\|WP_167321334.1\|2395127_2395787_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NC_008554.1\|WP_011698804.1\|2383163_2384300_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NC_008554.1\|WP_011698798.1\|2372405_2372816_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|376344
NC_008554.1\|WP_011698801.1\|2377160_2381462_-\|RHS-repeat-associated-core-domain-containing-protein	unknown	unknown	gnl\|CDD\|274730
NC_008554.1\|WP_011698809.1\|2389396_2391853_-\|NADH-quinone-oxidoreductase-subunit-NuoG	unknown	unknown	gnl\|CDD\|236170
NC_008554.1\|WP_150109637.1\|2396321_2397176_+\|solute-binding-protein	unknown	unknown	gnl\|CDD\|379243
NC_008554.1\|WP_011698800.1\|2374730_2376548_-\|RHS-repeat-associated-core-domain-containing-protein	unknown	unknown	gnl\|CDD\|274730
NC_008554.1\|WP_011698812.1\|2394124_2394655_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698797.1\|2370045_2372409_-\|NADH-quinone-oxidoreductase-subunit-B/C/D	unknown	unknown	gnl\|CDD\|183955
NC_008554.1\|WP_011698810.1\|2391930_2393196_-\|NADH-quinone-oxidoreductase-subunit-F	unknown	unknown	gnl\|CDD\|224806
NC_008554.1\|WP_011698796.1\|2369010_2370006_-\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|376297
NC_008554.1\|WP_011698811.1\|2393203_2393695_-\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|181024
NC_008554.1\|WP_150109474.1\|2374482_2374734_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698808.1\|2388198_2389164_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_008554.1\|WP_041440268.1\|2376888_2377140_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698805.1\|2384834_2385173_+\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|238008

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698807.1\|2386132_2388031_-\|phosphoglucose-isomerase	gnl\|CDD\|236551	PRK09533, PRK09533, bifunctional transaldolase/phosoglucose isomerase; Validated.	0
NC_008554.1\|WP_041440261.1\|2373549_2373870_-\|IS1182-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.93742e-11
NC_008554.1\|WP_011698795.1\|2368234_2368771_-\|NADH-quinone-oxidoreductase-subunit-NuoI	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	1.18093e-66
NC_008554.1\|WP_011698804.1\|2383163_2384300_-\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	2.17304e-51
NC_008554.1\|WP_011698798.1\|2372405_2372816_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|376344	pfam00507, Oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.	3.30363e-40
NC_008554.1\|WP_011698801.1\|2377160_2381462_-\|RHS-repeat-associated-core-domain-containing-protein	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	1.01476e-34
NC_008554.1\|WP_011698809.1\|2389396_2391853_-\|NADH-quinone-oxidoreductase-subunit-NuoG	gnl\|CDD\|236170	PRK08166, PRK08166, NADH-quinone oxidoreductase subunit NuoG.	0
NC_008554.1\|WP_150109637.1\|2396321_2397176_+\|solute-binding-protein	gnl\|CDD\|379243	pfam13531, SBP_bac_11, Bacterial extracellular solute-binding protein. This family includes bacterial extracellular solute-binding proteins.	4.14742e-54
NC_008554.1\|WP_011698797.1\|2370045_2372409_-\|NADH-quinone-oxidoreductase-subunit-B/C/D	gnl\|CDD\|183955	PRK13292, PRK13292, NADH-quinone oxidoreductase subunit B/C/D.	0
NC_008554.1\|WP_011698810.1\|2391930_2393196_-\|NADH-quinone-oxidoreductase-subunit-F	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	0
NC_008554.1\|WP_011698796.1\|2369010_2370006_-\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|376297	pfam00146, NADHdh, NADH dehydrogenase.	3.03997e-140
NC_008554.1\|WP_167321334.1\|2395127_2395787_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	5.27783e-48
NC_008554.1\|WP_011698811.1\|2393203_2393695_-\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|181024	PRK07539, PRK07539, NADH-quinone oxidoreductase subunit NuoE.	3.12642e-74
NC_008554.1\|WP_011698808.1\|2388198_2389164_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	7.53576e-72
NC_008554.1\|WP_011698800.1\|2374730_2376548_-\|RHS-repeat-associated-core-domain-containing-protein	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	4.85396e-32
NC_008554.1\|WP_041440272.1\|2385383_2386070_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|238244	cd00429, RPE, Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose phosphate pathway. In the Calvin cycle Ru5P is phosphorylated by phosphoribulose kinase to ribulose-1,5-bisphosphate, which in turn is used by RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) to incorporate CO2 as the central step in carbohydrate synthesis.	8.63513e-122
NC_008554.1\|WP_011698805.1\|2384834_2385173_+\|EF-hand-domain-containing-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	2.44866e-08

>NC_008554.1|WP_011698804.1|2383163_2384300_-|PAS-domain-S-box-protein
MKLIEACCTHGELWEIILSSIKEAIILSDTAGRVLSASPAVERILGYKPHELEGEDLSLLFTSEDVSCLCPNILHLAVKHRRFDGELMLVRKDGSRFVCSMSVERHVDPEEGKEILLFCVEDVEKRRELERTAAGSHYQDLIKIANGIAHEIRNPLVSLGGFLNRIYKTHSGDDELMKYHDISMRSLRRIENLIAKVELFARLPTPQLEETVIRDLIEELAKSYEDELRKRKIELHLTVDDAVLLVDRNLIAKALAIIIENAIQVLPGGGRIEILSRSMSDQYELSVIDNGPGISADDLPYVFNPFFSTRPDGVGIDLAVVRRVAETHGGCVGVISSPGEGATFYLRLPVERRRSIRTMRLSEDHGVKPTLFTFHKSP
>NC_008554.1|WP_011698801.1|2377160_2381462_-|RHS-repeat-associated-core-domain-containing-protein
MANKIFRRSARFFLCVFVLSCPLVWAGLPVAPGLNSPGNDTWVPLTETARIETASAARCLLAAHAGGKGATGLSPSPGHGEALSAKPALEDLDYGVDTEAFFPGGDVLGGTVSILTGNAVETAADLAYPSAHRLGLTFGRTYNSRAETSGILGTGWTHTYGASLTPPVSPDPYLKVVDSTGRARYFTEESAGVYRGAFNDHTKVLVLVNGNYAWYPLDGTIFIFSPTGLLLHIQDIAGNRLSLTHDAQNRPSTVSDPSTGRALTFSYNGSGLLETITGPLPNTTSTGTVATFTYDANSNLTSVLYADNSGFTYEYADANDVHNLTLTQNKANHTLFEWTYDAQDRCAWHRSRRARGSFSVSYVSDTQVDVTDPYNWVRSYTVATVAGRKRVTAVVNPAYPGDPDKAANAPYAASNALAWTYDASTGNLTDATFPRGVVNQFRNFIVRGYPQTVILAAGSAQPRTIAYTWHPSMNVVLTRTEASVLGAGNKETIFDYDDPAAAGDDPAVYNESPTKLLYRKIEKGYRKTVAGTVASYEYVTALTYNAGGQVLTIDGPRSGTGDTTTFAYDATTNDLLSVTRPLVGATVFSNFDAAGNPRKLTDVNAQEQTFVYDSRGRIKEIHNTADSSVRTVTYNVAGLPATRTDEDGVNESHTYDNTYGQPRRVTDHEGNYVKTIFNAAGNLTSVQHLTAADEITRERTWSYSGSDYPGLLFKEYEADGVTHTRTQYDASGNVRSVVDPNGNQTDYAYDAFNRVISITRPGNAVTHFEYDSQGNLAKVVDPEGDPANPALGHTTTTTYDDMGNLIGVGSPDSGTTTYGYRPEGTIWWRIDARNIQTTYSNDALYRINQASYPAVGDLAAYTVTYSHDQRANGKGHLTTVTDPSGTTLLNYDARGRLKEKKSTVSGFQFTLSRTFSPAGRVNQLTYPSGRTVTYSRAGCGCKLTGVSTTYGAESATTILENLSYQPFGQATGMGWGNAGSVVSEYDLNGRLTTANRGAPMQRDFTYYPNGQLHTVAGTASTPWVNRVYAYDTLDRLSLAERPQLTKAYDFDSAGNRLHTIVDASVSETYAYAAGTNRLSAVAAAQGKTFDYDANGNTILIASGTNRVFTYNQENRLIGVAEDGNPLGTYVYNGFGQRAAKTAGGVATLYIYDFSGNLVCEAEGTGGGIQKEYIHHGRSRLAMADPGAGAVCSGNTKVCVYFTHNDLLGTPEFMTDSTNTAVWEAAYDAFGEATIHPASTVVNNFRFPGQYYDAETGLHYNWHRYYDPKTGRYMTPDPIGLAGGINPYTYAENDPINFIDLYGLWRFPDYVSINFNIAIPTPWTATLLGGTAQVALDRYGNFYAGPGGTVGKAATVFSLSATVGWLDTSEKPCEKTLDNFLSGHSFNAGAGFWGGGGETWTPGVGTGTEVGFVSPQAGASYHYSWKVTKFGFGW
>NC_008554.1|WP_041440268.1|2376888_2377140_-|hypothetical-protein
MKNELGTLMIASTFLLGGVACFFFPDKIQTAALKYFARYPSAARLNPFLEWMKSHSYIISLRIVGFIGIAVFFLTLIAFARGR
>NC_008554.1|WP_011698800.1|2374730_2376548_-|RHS-repeat-associated-core-domain-containing-protein
MGNLIGVGSADSGTTTYGYRAEGTLVWRIDARGIRTDYTSDLLYRIKEASYPAVGDLGAYTVSYTYDQRANGKGHPTTVTDPSGTTLLNYDARGRLKEKKSTVSGFQFTLSRTFSPAGRVNQLTYPSGRTVTYSRAGCGCKLTGVSTTYGAESATTILENLTYQPFGQATGMGWGNAGSVVSEYDLNGRLTAANRGASMQRDFTYYPNGQLHTIAGTASTPWVNRVYAYDTLDRLSLAERPQLTKAYDFDSAENQLHTIVDASVSETYAYAAGTNRLSAVATAQGKTFDYDANGNTILIASGTNRVFTYNQENRLIGVSEDGNPLGTYVYNGFAQRAAKTAGGVATLYLYDFSGNLVCEAEGTGGGIQKEYIHHGRSRLAMADPGAGAVCSGNTKVCVYFTHNDLLGTPELMTDSTNTAVWEAAYDGFGEATIHPASTVVNNFRFPGQYYDAETGLHYNRHRYYDPKTGRYMTPDPIGLAGGINPYVYTENDPINKIDLAGENTIAIGAGAGSFIGGPPGAVIGAAIGAGIGVAAGYAISEPCKEDDLERKCEENLTRDLATCSALGKRDGKTAYAICERQAYARYARCLQGSDITPPLPPWGTK
>NC_008554.1|WP_150109474.1|2374482_2374734_-|hypothetical-protein
MTKQKRAVMIGLERSANSKLKITMDDLIQISDKPSKWIKDVIITFKEYDDSIFEELDFTEKDLADFGYSIIARLYAFYKQGEI
>NC_008554.1|WP_041440261.1|2373549_2373870_-|IS1182-family-transposase
MEKMFKSCDRKQLLLLPPSLLDWLPEGHLAHFILDVVEQLDLSELYASYKGDGRGQPPYEPGMMTALLFYAYCTGFPSSRQIEKRTHEDVAFRVIAANRHPDHDSI
>NC_008554.1|WP_011698798.1|2372405_2372816_-|NADH-quinone-oxidoreductase-subunit-A
MQPISPDGSLSPWEPGMFSLAVYAVLVAAFVAVQLFVAWWLGERKPGVEKARPYECGIIPTGSARLRYPVPFYLVAIFFLIFDMEGAYILTWAVAFEELGWAGWLQMSFFIGLLLVGLVYVWKKGGLDWRPSYGKK
>NC_008554.1|WP_011698797.1|2370045_2372409_-|NADH-quinone-oxidoreductase-subunit-B/C/D
MSDRFLSAADFVLNWSRKYSLWPLFFGLSCCFVEEATAFTPRYDMARFGAEVLRPSPRQADLLIVSGTVFKKIAPVVLRLYEQMAEPKWVISMGSCSNCGGMYDVYSVVQGIDQILPVDVYIPGCPPRPEAVLQGLTLLQKKIAAEERPARSVLHLPGGSQGSTRPVLVDGATKSRDPRGPGMEGTVIRGTANTPPAFTGSRSDLMWTPPARRIESSEREKELARVLSERFGDAVREEPFTSDMPTFHVETNRLKDVLGFLKKEASPRFLRLDDLTAVDESARRDRSAYPDWTMVYHLLSFEPAGRVRLKTGLHGRQPALPSITDIWPSANWYEREVYDLFGIRFEGHPNLRRIMMPHDWEGHPLRKDYPGRATQMAPYTLGDARVHQPPDGGIFTKDPGGDRLVLNIGPSHVSTHGLLRYVVSLDGEEISDLELEIGYHHRGVEKIGERQTWHQFIPYCARVDYLAGAANDLPYVMAVETLADIKVPERAQVIRVLLSELFRLSNHLVWFATYAHDVGAMTPNFYTFTEREMILDIVELITGGRLHPSWFRLGGVAADLPEGWKEAVDALVRIFPGRLREYESLIRKNPIFKARTQGVGRISREDAVDWGVSGPNLRACGLEWDLRRKFPYSGYENFEFEVPTAVEGDCYARYLVRVEEMRQSLRIIEQAAANMPSGRHVTDDYRYVIPDRRDTLKNIESLIHHFVNVTRGPRIPKGEAYVSCEIPRGEQGYYVVGDGLGYAYRMRIRGPGFANVQVMPLLARGESIADLIAIIGSVDYILPDIDR
>NC_008554.1|WP_011698796.1|2369010_2370006_-|NADH-quinone-oxidoreductase-subunit-NuoH
MLNWTAGFLVLIAKLTIVLAVLLLVAAYLVWLERKFLARLQIRYGPNRAGKFGLLQPIADIVKMVAKEDTVPEGAERTIFMLAPAVVAATALLVFAVIPFGKDVTLWGMKIPLVVADLNVGLLYFFALSSLGVYGVALGGWASNSKYSLLGGIRGAAQMISYELSLGLAIVPVVMQARSFSLVDIVQAQEKYPFILTQPVAFAIFVISAMAEIKRIPFDLPEAENELGAGFHTEYSGMRFGLFFLGEYVNMQVLGGLVAVLFLGGWHGPLLPPVVWLFIKIVLVALIMIWVRGTLPRLRYDQLMALGWKVLIPLALVNIMVTGAWVLWMGK
>NC_008554.1|WP_011698795.1|2368234_2368771_-|NADH-quinone-oxidoreductase-subunit-NuoI
MSSAWEAVRALASGFATTFVHLFRKPVTEEYPEVKRALPARTRAVIVLTRDPDGGERCVACYLCSAVCPVSCISMQAAEREDGRRHAAWFRINFARCIYCGLCEEACPTSAIQLTPFFETCERDILKLVYEKEDLLVDHQGKDKEYNFYKYAGVTTDVGGKGEHVQEDEPVDLRSNLP
>NC_008554.1|WP_011698805.1|2384834_2385173_+|EF-hand-domain-containing-protein
MKASRRTALGMALLIALTVFWTGLAAAQSTQAQSAQRPMMRCSERFDKLDTNHDGMVSKDEFMAVPHRRGNAEQNFANRDGNKDGTLTREEFCSGAGPGARGKGGGRGPMPQ
>NC_008554.1|WP_041440272.1|2385383_2386070_-|ribulose-phosphate-3-epimerase
MTEFPESERKRKSKLSASILSADFGKLAEEVKAVERAGTDWIHVDVMDGHFVPNITIGPDVVKAIRGVTALPLDVHLMIEKPERYIEAFIRAGAHYLGVHAEVSPHLHRTVQRIRELGARPVVTLNPSTPLCAVEDVLGDIDMVLLMTVNPGFGGQKFIPSMLPKIRRCREMIDESRLPVLLEVDGGVNRGTIDDLVDAGVDVFVAGSAVFAGNDYARNVNGLVERMR
>NC_008554.1|WP_011698807.1|2386132_2388031_-|phosphoglucose-isomerase
MLRCRSAKGGYGSTVPTTEPAARRATVFQVAPRDAGHGELRATRLQLPSGSQDDTMSEETMTKKVSDLYPVNAFLGGHAAEIQARIEALEKDRFASRFWRKDPDLWKSDPENRKSIANSMGWIDLPDKISLHAPALAEFARDLRICRFKHVVHMGMGGSSLAPLAFREIFEPGAEGLALTVLDSTSPSTILEIERRLPMAETFFIEASKSGATVESRSLGEYFHARMRAVKGKGAGVHFAVVTDPGSVLVKLAEERNYRGTFLNFADIGGRYSALSFFGLVPAALMGLDVEEILARGLSMMEACGPDVPVKKNPGMTLGVVMGEMALRGRNKLTVIASESLSALGMWLEQLIAESTGKEGKGIVPVVGEPLGDPAVYDDDRLFVVLCLEDEVDGVLESRIDALRKAGHPVIVVPMADRLDLGREFFRWEIATATAGAILGINPFDQPSVQESKDITKRFLEQVRDEGCLVEGKIELGDGPLQFYGIAPGAASAGQALSRFLKGARSGDYLAFLAYLPEASGVEPGLRNLRGLVRDRLKLATTLGFGPRYLHSTGQLHKGGPNTGVFLLITCDDPEDAPIPGQPYTFGVLRRAQALGDFEALAKHGRRVLRVHIAGNPVKGLAALEKAFREAL
>NC_008554.1|WP_011698808.1|2388198_2389164_-|ROK-family-protein
MSSKRYAVGVDLGGTKIAVALVDDRGEVLKHARYLTFVREGPEAVRDQIIGAVKEIRKGTKTRPAGIGIGVAGQIARDDGMVRFAPNLGWRNIPLGEQLRAITRLRVVVVNDVRAAAAGEWAFGAGKDCGDLICMFVGTGIGGGIVAQGRMLHGCGNSAGEIGHVVVDMNGPLCHCGRRGCMEALAGGWAIAQKARDAILLDPALGTPLLRLAKGQINNVTTELVATAFRMGDPLARQLIDRAAEALSVGAVSLVNAFNPCRLILGGGVVNGLPELIERVREGIRHHALVTAAESVTVVPASLGDDAGVIGAAVLAMQSPA
>NC_008554.1|WP_011698809.1|2389396_2391853_-|NADH-quinone-oxidoreductase-subunit-NuoG
MPSLIIDDLEIEVPQGTKVIEAAERLGIMIPRFCYHHALGSAGACRMCAVKFLQGPFKGVQMSCMIEAQDGMVVSTTDEEAVSFRKQVIEWLMLNHPHDCPVCDEGGQCLLQDETASSGHGIRRYAGRKRTYRDQYLGAFIAHEMNRCIHCTRCVRFYQDYTGYRDLGTMGIASHVYFGRYGDGPLESPFAGNLVELCPTGVYTDKPSRYKVRHWDLERSPSVCIHCSLGCNTVAAARYREIMRVEPRFNEAVNGYFICDRGRYGLAYVNHVERPRGAVVDGVETDCETAVRAASERLSAICAEAGSDAAAVLGSARNSLETQVRLERLVKRKGWRAPRYFVDPGLAHRVERAVAGLSDRTAVSLREIETADVILAVGVDPVNEAPMLALAMRQARRREAFVTVVDPRPVSLPFAFEHIAMHPDDIDRFLDALTELMRDPAQKPVSGARAVGKADSIAVPAGKLAGGGFPVIVCGTAVTRETTPDRAAGLADAILERGSRTGLFYVLPGPNAFGAALWAPARQRSFSETLEGIENGAIKGLLAVEADPLREFPDRPRLERALKKLELLVAVDCLPSEILRLAHIVIPSSTLFESGGSYVNQEGRVQYAEPVYRGGVPIGQAGGGSHPPRAYGVGVPGAEPRSAPLILAALAGDADASPADRSRPDVPFREIADECPALAVIGQSYPVDGIRVVPAKAGAENPTAQVARYETARRDDVLELILADMTFGSEELSHYSHITQQVEPQPHAVMHAADAAAAGLSDGDRIRLNFAGGPVEIDLMISTTVAQGVLIVPRHRDVDWRRIGSFRATIPLSAVEKV
>NC_008554.1|WP_011698810.1|2391930_2393196_-|NADH-quinone-oxidoreductase-subunit-F
MYPQVLFRNRKPDRIVTLDEYRAGGGYRALGDVLRKRSAGEVCRVVDEAGLRGRGGAGFPASKKWESVPADGAYPRYLVANSDEMEPGTFKDRVLIHADPHTIIEGMILAGYAIGASKAFLFVRPSYESSAAIMERELRIAREAGYLGRNILGTDYSLDIVVHRSGGRYICGEASALLNAVMGKRPNPQRPPPYPTVKGLWERPTVVNNVETLANVPHILRNGPEWFRGLSRSKTPGTKLFCISGKVSRPGCVELPMGTRLNEIIEEHAGGMAPGSEFKACLPGGASTYFLTRDNLHAGMDFDGMAAVKNRLGTGAVIVFDRKTCLVGATLNLMRFFARESCGWCTPCREGLPYMRDLLERIEEGEGREEYIPMLRLMSRQVWNSYCALAPGAASPVESLLDHFADEVHEHISQKRCPFKD
>NC_008554.1|WP_011698811.1|2393203_2393695_-|NADH-quinone-oxidoreductase-subunit-NuoE
MIPEEMRSALARKAASAESPREQAIDVMFELQDHYGYMTDEAMEEAAGILGMTTLELEELATFYDHIYRSPVGRYVIHVCDSAVCWMEGYQRIIDYLCQRLKLTVGGTSPDGLFTLLPVCCIGYCDRAPAMMINRNVYGRLTREKIDRILDRLIEHSQFHEME
>NC_008554.1|WP_011698812.1|2394124_2394655_+|hypothetical-protein
MAEIKSTLDLVMERTRNLTLTEDEKREQALTEFRQRFSGLTGRYLDGLLPIEGFRKELQSLRETVPALNGDILCDEIARRLDPDRDNRQLLALLSEVCAVDTGVIESLLDEYAATLASMTRDRIDHVKMLLLDACKVSGSAVVPNLDADSDWAGEKEALREKVVEKLGREIAAAKR
>NC_008554.1|WP_167321334.1|2395127_2395787_-|MBL-fold-metallo-hydrolase
MKIMEGLHAFMWNSMSANNCNTYLIDAGARVLIDPGHLTLFEHVNAGLKELDLGPGDIDLILSTHVHPDHVEAVKWFNGTPALFAVNEEDWRLFREMAISLGAGMDVEAYVPDFFLAEGELDVKGLKLEIIHTPGHSPGSVSIYWRERKVLFTGDVIFKEGLGRTDLPGGNGELLKRSIKRLSEFDAEWMLAGHGDVVAGAERVRRNFENVARYWFNFI
>NC_008554.1|WP_150109637.1|2396321_2397176_+|solute-binding-protein
MDKQNGHNRRTFLKTALASAAGAVLPAGESRAAAFSRDTLQVWSCGGLAEAFMPANALFEGRTGVRIAYTGAFAAALGKSLLGNAKTEVFGGRVLDLAKKLRQAGKMVYFKPLCFTTYVLATPRGNPARVQSVQDLARPGVRVILAPDASPPGGQAAQVLLKKAGVLEPAMKNAVSLGSCVQRTMEELAEGRGDVSVVELRLTRMPEFQGRVEIIPIPFELFPPPPLTFTIGVMKDAEDRALADHYVEFITSSEGQAFFERAGFIPAISDRGRELTEKLGVKDA

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Crispr_ID: NC_008554_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_16

2460068-2460167

Orphan

Consensus_repeat	Method
GCGACACCCGCGAAGCATGAAAACAGGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_16

>merge|NC_008554|16|2460068-2460167|CRISPRCasFinder
GCGACACCCGCGAAGCATGAAAACAGGCTCCCGAGGGAGTCTATTTTCTAGGTAATTCCCCATGGCGCCCGCGACACCCGCGAAGCATGAAAACAGGCTC

>NC_008554|16|15|2460068-2460167|CRISPRCasFinder
GCGACACCCGCGAAGCATGAAAACAGGCTC	CCGAGGGAGTCTATTTTCTAGGTAATTCCCCATGGCGCCC
GCGACACCCGCGAAGCATGAAAACAGGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011698852.1\|2448095_2449955_-\|fumarate-reductase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|181507
NC_008554.1\|WP_011698860.1\|2457531_2458203_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_008554.1\|WP_011698872.1\|2471129_2472329_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698870.1\|2469155_2469581_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698868.1\|2466340_2467462_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235064
NC_008554.1\|WP_011698857.1\|2453641_2454136_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_008554.1\|WP_011698854.1\|2451146_2452094_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_008554.1\|WP_011698867.1\|2465181_2466225_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NC_008554.1\|WP_011698869.1\|2467467_2468781_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NC_008554.1\|WP_011698866.1\|2463895_2465185_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NC_008554.1\|WP_011698856.1\|2453240_2453465_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011698853.1\|2449965_2450631_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238325
NC_008554.1\|WP_011698862.1\|2458973_2459483_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_167321336.1\|2454393_2455881_-\|DegQ-family-serine-endoprotease	unknown	unknown	gnl\|CDD\|273938
NC_008554.1\|WP_011698865.1\|2461595_2463899_-\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376913
NC_008554.1\|WP_011698855.1\|2452160_2452931_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|225070
NC_008554.1\|WP_041440293.1\|2461069_2461546_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NC_008554.1\|WP_011698859.1\|2456111_2457521_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|273593
NC_008554.1\|WP_011698871.1\|2469818_2470709_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|214854
NC_008554.1\|WP_011698863.1\|2460218_2461073_-\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011698852.1\|2448095_2449955_-\|fumarate-reductase-flavoprotein-subunit	gnl\|CDD\|181507	PRK08626, PRK08626, fumarate reductase flavoprotein subunit; Provisional.	0
NC_008554.1\|WP_011698865.1\|2461595_2463899_-\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	0
NC_008554.1\|WP_011698855.1\|2452160_2452931_-\|amidohydrolase-family-protein	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	6.40922e-11
NC_008554.1\|WP_011698868.1\|2466340_2467462_-\|histidinol-phosphate-transaminase	gnl\|CDD\|235064	PRK02731, PRK02731, histidinol-phosphate aminotransferase; Validated.	3.64353e-121
NC_008554.1\|WP_011698860.1\|2457531_2458203_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.98346e-88
NC_008554.1\|WP_011698859.1\|2456111_2457521_-\|HAMP-domain-containing-protein	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	1.18148e-69
NC_008554.1\|WP_011698869.1\|2467467_2468781_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	3.14597e-05
NC_008554.1\|WP_011698866.1\|2463895_2465185_-\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.33844e-27
NC_008554.1\|WP_011698867.1\|2465181_2466225_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	0.00634352
NC_008554.1\|WP_011698853.1\|2449965_2450631_-\|hypothetical-protein	gnl\|CDD\|238325	cd00581, QFR_TypeB_TM, Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone oxidoreductase (SQR). QFRs oxidize low potential quinols such as menaquinol and rhodoquinol and are involved in anaerobic respiration with fumarate as the terminal electron acceptor. SQR and QFR share a common subunit arrangement, composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunit. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron donor (quinol). The Type B enzyme from Desulfovibrio gigas is capable of fumarate reduction and succinate oxidation.	2.24206e-59
NC_008554.1\|WP_167321336.1\|2454393_2455881_-\|DegQ-family-serine-endoprotease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	6.72686e-175
NC_008554.1\|WP_011698854.1\|2451146_2452094_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.43019e-32
NC_008554.1\|WP_041440293.1\|2461069_2461546_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	2.72444e-74
NC_008554.1\|WP_011698857.1\|2453641_2454136_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	5.37934e-32
NC_008554.1\|WP_011698871.1\|2469818_2470709_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|214854	smart00849, Lactamase_B, Metallo-beta-lactamase superfamily. Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.	1.28764e-24
NC_008554.1\|WP_011698863.1\|2460218_2461073_-\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	1.16574e-64

>NC_008554.1|WP_011698862.1|2458973_2459483_+|hypothetical-protein
MKALRSRNSLWSLMVLLLAMAFLAGIRGTTAAAQAKRLDSKAVNPVTIGRDGPQSGRFTANELNVEYKYVFSGSNMQLSGSVRFASPIAANYSVVRTFELGLILADAQGNVLHRQMLTTSYDNNVNDAIPFTHTVLVPPQATVMVFSYSGQAYGPGSSPTNFWLDPVTK
>NC_008554.1|WP_011698860.1|2457531_2458203_-|response-regulator-transcription-factor
MRLLVVEDEKKVASFIRKGLEEEGYAVDVALDGEVGLQMAMDRVHDLIILDIQLPRLSGMELLRSLRAKRISTPVLLLTVRATIEDKVLGLDAGADDYLTKPFSFRELVARVRALLRRRAESSQTELRVADLTLDPVRHTVSRGSEKIELTAKEFALLDYFMRNPDRVLTRTMIAEHVWDYDFDSMTNVIDVYVNYLRRKIDSDREPKLIHTVRGVGYMLKTE
>NC_008554.1|WP_011698859.1|2456111_2457521_-|HAMP-domain-containing-protein
MKSIRARLTLWYTSLLTVTLVLLGGTAYALLSYSLSHEVDAALNGVARSLTERAHGPSAFVPAEVDEAFRRFFGFSPWNRYFQLFDPLGHRDPRQPAPHSGRLPLSGEALNNAANGISTYETVPGSEEHPVRVLTMPVMEGGRMVNLVQVGMSLKSVLETRTRFLLIMAVLFPVGLVLAATGGLLLARRALRPVDRMAEAARRISAEHLAERIGGTGAGDELDRLASTLNEMLGRLDTAFTQVRRFSADASHELQTPLTILKGELEVALRSPRTPEEYQAVLKSALEEIDRIAHLVEGLLLLARAEAGVLRMDRRPVDLEQLAEEVYWRLKVLADSRSIRFDSELAEPVVVPGDRERLRRLLFNLVDNAIKYTRPGGVVRLSVRSADGTAVVDVSDSGPGIAAEDLEKIFLPFQRVPMTAPGTERGAGLGLSIARSIATAHGGRIQVRSFPGKGSTFSVYIPMSPEAPS
>NC_008554.1|WP_167321336.1|2454393_2455881_-|DegQ-family-serine-endoprotease
MSNELRPFLQGRHLKAKVTTMVVAAFFVGGLAASSGLNPGRLLAVPDAAQAAPAEGDQPGVTPTSPFATLAAKLTPVVVNVRVTKIERAEFPDFEGPEQPFGDFFRHFFGDRRGFPNVPAQGAGSGVIIRGDGYVLTNNHVVEGAREVTVTLSDKQEHKARIVGRDAKTDLALLKIEAGKSLPAASLGDSDQLKVGDWVMAIGNPFGLSETVTSGIVSAKGRVIGAGPYDDFIQTDASINPGNSGGPLFNMKGEVVGINTAIIPNAQGIGFAIPVNTAKPLIPQLETKGEVTRGYLGVSIQSITPDLASAMGLGDGKGALVADVVEGGPADRAGIRRGDVILAFGGKDVKDSHDLSFMVAAAPVGRESAVTIMREGVERRLDVKIGKQESEEGAKEEFSKQAHGKWGLQLRDVPPRVAEELGLESERGALVAGVLPGSPADRAALRQGDVILEVNRQPVTSASELKERIAGAGERGALVLLVQSSRGTRYVVLKG
>NC_008554.1|WP_011698857.1|2453641_2454136_-|N-acetyltransferase
MEYAFEPITRKHREAVIDIFNHFVVNSYAAYPERPVEYDFFDYLYVEPRDYPAVAVTSETAGIVGFGFMRPYDSDESFKHTAEVTYFILPSHTGKGLGTGMLRLFCDQALHRGIRSLMANISSLNDASISFHLKNGFQEWGRFYRVGSKFGVEFDVLWMEKCLK
>NC_008554.1|WP_011698856.1|2453240_2453465_+|hypothetical-protein
MKLTGIVLVFVLAAFLTGCAGMTATQQRMLSGGAIGTAAGLGTAAIVGAPLAVGAAAGAAAGVVGGYVVDEIER
>NC_008554.1|WP_011698855.1|2452160_2452931_-|amidohydrolase-family-protein
MQPSDIIDAHAHCGRQDRSPPQALEDYLEHSRGSGIVGAVMFPPVYEIYDRYDYSFEDNDHWRRRRDAANRYLIELETPFEVIPFYFVWNDFAVDNITPLHRGIKWHRHSDEPEYHYDDPRCLAVLSEIRRRNMPVVLEEEWHKTTMFIDTLASGIRVVIPHCGLLNGGYERFRRQDIWGHPDIYTDTSLVPGEVITDYVDRYGSERIMFGSDFPFGDPRHELGKIMRLRLADAEKEALVGGNVRRLLGGGGGRVG
>NC_008554.1|WP_011698854.1|2451146_2452094_-|EamA-family-transporter
MDQGAAVIPRRGYLYVIAAALLWAVSGVSGKFLFQRGVTPMELVQLRVTLASGLLFAWFLLSHRERLRIARRDILYFFILGAVGMATLQFTYFYAISKINVAVAILLEYLAPAFIAIYSVVFAGERLTRPTLAALGGSLAGCYLAVGAYNFDLLAMNWKGIVVGIISAISYAWYAVHGEHGMRRYDPWTVLFYALLFAGVCWNIVLPPLSAFRYTYSSVEWAWILYIGVFGTAIPFGLYSKGISLIRATRASVTATLEPIAAGFVSFFFLDERLQPLQIAGGVLVIVSILLLQMRKEYDDNTAALIRARRGDLDT
>NC_008554.1|WP_011698853.1|2449965_2450631_-|hypothetical-protein
MSDQTLAARVEPVRTDAYLDFFQMLTGVLLVLFMWMHMILVASVNLDFGGGRVMNWIAHFFEATYMAQLGGPMIFLTMLAHFVLASRKLPFQAREQKAIWAHSKRMNHLDTWLWMVQAATAFIILVMGSIHMWVVLTNLPITAARSGARIQTGWWLLFYMVLLPMIELHVGIGIYRIGVKWGYIKRANRSFFHSLENKVTLVFITIGAITLFTFYVLVKPM
>NC_008554.1|WP_011698852.1|2448095_2449955_-|fumarate-reductase-flavoprotein-subunit
MDTFYTDLLCVGAGLAGERVAVAAASEGFSTICLSIVPPRRSHSSAAQGGMQASLGNCCMGEGDCPDVHFADTVKGSDWGCDQECARLFAETAPIAVREMAFWGIPWNRVVAGEGTYYKGGKQYQKIEKKEMEGTITARDFGGTAKWRTCYTSDGTGHTLLFTMDNKVVELGVTVHDRVDAISLIHDGETCMGVVARDLKTGNLRAYLAKATLIATGGYGRTYRETTNAVINDGSGVILALDTGIVPFGNPEAVQFHPTGIVPTNILVTEGCRGDGGTLKDVNGERFMHIYEPGKQELASRDVVSRWMTHHIRIGKGVPSPYGPHLWLDIRHLGAAHIKTKLRDVEEICNEFLDVDPITQMIPVRPAQHYSMGGVRTNKDGAAYGLKGLFAAGEAACWDMHGFNRLGGNSLAETIVAGKIVGEKIAEFLKGYEVNIKTEVVRDAVNKQEARIAALIAGRDGKESVYAVRNAIQDALMEGVGIFRNEADLKKAVDTLQVVYERSKKVGIQSRVIGVNPEVAMALRIQGMCRIALCVAYAALQRTESRGAHAREDYPERNDRDWLKRTLATWKEGDNLPTLNYEKPSKVWELPPGERGYGVAKIIYSEDPEVIGSSKPATN
>NC_008554.1|WP_011698863.1|2460218_2461073_-|xanthine-dehydrogenase-family-protein-subunit-M
MTNVLIPESMEELRRILETHPGARVYAGGTDLLVKMRSGLEAVPPCLVCLERIAELDAVSEHGEVVRIGACVTHTRLLADPVATEHLPVLVRAVEVLGSRLIRNMGTIGGNVCTASPAGDTLPPLYVLDAELELRGGTGSRIVALKDFIKGPGQTVLGENEILAAVRIRKPRMFNLFHYEKVGQRKGLCCSAVSLAAMLRVSSGGVVEDAALAWGSVGPTVVRSREIERMLIGKELTAERMREAAAEVGKIVSPISDVRADAAYRRAVAGNLLLRLAARDGSSP
>NC_008554.1|WP_041440293.1|2461069_2461546_-|(2Fe-2S)-binding-protein
MKLRFVLNGESVEIEVRPDRRVVDLLREDFGLTGTKECCGSGECGGCTILVDGDCRLSCLMLAAQLHGREVVTIEGLSRNDRLHAVQEAFMEHGAVQCGFCTPGMVLAAVSLLARQPRPSREQIREGLSGNICRCTGYVKIVDAVEAAALKLANGDRR
>NC_008554.1|WP_011698865.1|2461595_2463899_-|xanthine-dehydrogenase-family-protein
MTLRHGTLEIGCPVPRVDAAAKVTGEEKYAIDHTPENMLWAGVRRAGVPHGRLRTVHVEEARALPGVLCVLTASDVPGTNRQGIVHKDQPVLAVDRVRHCGDPVALVLAEDRETLAKALALVVPDIEPLPSVHSPEEALRPDAPAIHDSGNVLLRAVIEKGDAGGAFGECDAVVEETFEVPFQEHAFLETQNGIAHREADGKLVMTVSTQAPFRDRFEIAHALGLDPFSIRIISPYLGGGFGGKDGATVQCLLALAAMHAGGRPVRMTWEREESFIAGYKRHAVKMHYRVGAKRDGTLHALECDLYYDTGAYAHLGAEVMELGMEHAGGPYRIPNVRVKGWCVYTNNPIAGAMRGFGVCQTAFAVESVMDMLAAKLNLDPLEFRRKNALRRGDENCAGVTMVHSTGIGACLETLSRHPFWLERRDWKRAAPPFKRRGVGLAAVFNAMGYGRGLPDSAIARLELTLDGRIRIYCGVSDMGQGNSAAFVQIAGEILCQDASRLELILPDTDRTHPSGSSSAGRTTYTFGNALVQACNALKEKLFHRAALVLMLDEEKGLALLPGRVRHLPSGREASFELLARMLPEADRASVGQFIMPVAHDVPDTGKEFAIGFPHVFFAYAAHLARVEVDELTGRIEVTEYLAVTDGGKVINPQGFEQQVHGSVAQGLGYALTEQLLLDRGAILNAGFADYILPTALDVPEIISVAAETFEHTGPFGMKGIGEVGTNGPLPAVANAVNDALGRRLTRSPLTASRILRAMEEGPAQPVT
>NC_008554.1|WP_011698866.1|2463895_2465185_-|MFS-transporter
MTSPAAGVPVLERDGSTSEPKRLLSFEFVLLSAVSFFGFCNIAVFYSFFSYLERIGVPAEWRGFLLGLEPMAAFALRPVAIAFLHAGNALRALVFSLVMIAVALCAYAFTTSLAGLAVLRIFHGAAFVFLVSSILTLIVHFIPKERSGQGFGILSVATLLPYAVMPFVTEALLPRTGDEAIIYAWISLFALPALILTLCCGKRIRAALEGVDSAVMGRPAAYEFLLNVRRADVLLLIAVNLLIYFCHSTVFFFMKSLALQMDAGNIGVFFPIYTLAMIVVRICGGAYFDRVNQLRAIEVFMALLAGFFLVFAHAASAEAFYVLAGSYGLCLGVVLPLLNSTMFRISPPRFRGVNTNLALFSMDAGFFLGPFAGGALLAGGCPPTRLLDVCAGFVCLALVLVVVLERISRRESRDTGCADAVARGVPGEE
>NC_008554.1|WP_011698867.1|2465181_2466225_-|GNAT-family-N-acetyltransferase
MNLAERVRRIEPEEHVLPSGEKMEVGLFRPEDGAGIGELFRTIYGDGYPARHVYDPVELAAALERGDNYPVVARGPVGKIIGHVALFRSSPYGKLFEAGAGAVLPEHRNAGINRLLLAFAYERLAPELELEETWGEAVCNHIYMQRTIATFNHVETALEVALMPAEAYEKERSAAGRVASVAVFRAYRPRPHVVRVPEAYAEALRFLYAGLDDARTLSPGEADIPPDSVSRAEVGMLPFAGVARMAVARVGGDFESRLDALEKDVLPQGFKVIQVSLGLGRPWIDRAVSALRGRGYFLGGVLPRWFDEDALLMQKIIGDPCWEGIRLFSERAAKILELVREDWRRTQ
>NC_008554.1|WP_011698868.1|2466340_2467462_-|histidinol-phosphate-transaminase
MSNFPPLDRLTPEYIRNFEPYIPSKPDEELKRLYGCERLFRLNNNENPLGPPPAARRVIREFPPPRASVYPSGDAYYLRLKLAEKFDMHPDQFLVGNGANEVISFAIKAFCEAGDNIVTADKTFAVYEWVATFSGFGAHLVPLADFGFDAEGMLRAMDDRTKILFVCNPNNPTGSIWKRGMLRGFLDRVAGSRIVVVDEAYAEFVEDPEFQNAMDLIPEYPNLVVFRTFSKMYALAGLRIGYLAGAMEVVDVIRRTCVVYSVNVLAQLAALAAIEECAEHIERTRELVRKGKSFLVREIGALGLEYVSGEGNFVMLKLPMNDGLAYRKLMTRGVMIRSMTGFRFPNWIRVTVSTDEAMECFIEALTEALGERG
>NC_008554.1|WP_011698869.1|2467467_2468781_-|ATP-binding-protein
MNREHTHAVVLRVRGNAVFLPLVTSFVELSAGAFGLGKKEALGLTLAAEEIFTHLCGVMGAKGGEVRVRCRTHGHYVRADFSFPAVDFDVRAFNLTAKVSPADDRCEDEMGLVLASRAVDRLNVTHARERGLRLTLIKEKAYPKTEADIPLSSRPLQQFSIRPPERDELKVLALLTGKYYRREGLPGFFDYPGKLVDMVGGGEYHALAALGPAGEIGGGILWCWAGSKTVEFYGPYVFEQEPNTRMRNALLDAAISTIARTPAVGLLNRCPPPDFPQEYFEPLGGIPLLSEDGTVLEQRAWFRLMHEDPGAVAWVHPELEEFVRGEFKRLVLPREVRMVRDEGETANAHSLLSADFDRPQKTVTLKPVWPGRDAGENVAGHVALLRCEGLRDVFFALDLGQSWQAVFTPHVLARGFVPRLLLPYAAEGDMVVFQLQV
>NC_008554.1|WP_011698870.1|2469155_2469581_+|hypothetical-protein
MNLDTARKIVIAVIALLIFREFASFLAAVAGAVPAMIGAVLVLSAQLFFSRLVGKGLRHYAYILIPTLVFTAVPVGLKVRRFLGIGGRSSLGLLWDITPMMVGFVLPVLLLLIAWWILGKQGPGVSEVRPEKIVNTASPQS
>NC_008554.1|WP_011698871.1|2469818_2470709_-|MBL-fold-metallo-hydrolase
MELRKFGCITVIPGRQESRYPYCTSLFIDDERKAVIDPGSDEELLRDIASRNRIDALICTHYHEDHTAFNRLFDDVPLWVHEAEEMCYRFYSTLLHCYGVDDGPFTGEWRDFLVGEFHYRERSPARTFRDGDILDFGRTKARVVHTPGHTFGHCALHFPDEGVLFLADLDLTPFGPWYGDRVSDIDATIASVERLLKIPADVYITSHEAGIIEGDITGLAERYLAVIDQREKKLLEFLEEEPRTLDEIVNRRIIYGKERLPLFFFDMGERGMMAKHLVRLIREGSVRERDGRFSLR
>NC_008554.1|WP_011698872.1|2471129_2472329_+|hypothetical-protein
MTFSEGSPIRVYTTAWGYKVLVAAVTIVGLAFFLMILGTAFSRSAPRGRDLTVAYVLLGAGSAMIACLAYVLASTFRTRLEVYSDRIRYIRLLGTKEIRMDAIRGFRMVTTQNREALTLVPKDPAVPSIGIALTIGDKKDFVEWAGRRLTNLDETEFQEEMKEALGDAALGSTEEERTLALRRAKRWATCLSVVGTGVALWAYIKPTPYEYAIGALIVLPPAALASLRFFRGALRFEWKARSAYSGIAPALCYSCGALALRAFQDWNILEWDNFGYSFIAVFLGMWFLAIMHAGDTWRKIPTALLLFGVCAAYGYGTTISVNGLLDASAPVPYQARVLSARGCTGKSSSYHLKLSPWGPRKEAKEIEVSRTVYRRYKTGDTVQVSVRNGRLGIPWFEVH

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Crispr_ID: NC_008554_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_17

3131653-3131746

Orphan

Consensus_repeat	Method
TCACCCGCGAAGCATGAAAACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_17

>merge|NC_008554|17|3131653-3131746|CRISPRCasFinder
TCACCCGCGAAGCATGAAAACAGACTCTCGAGGGAGTCTATTTTCTAGGTAATTATCCATGATGCTGCGCTTCACCCGCGAAGCATGAAAACAG

>NC_008554|17|16|3131653-3131746|CRISPRCasFinder
TCACCCGCGAAGCATGAAAACAG	ACTCTCGAGGGAGTCTATTTTCTAGGTAATTATCCATGATGCTGCGCT
TCACCCGCGAAGCATGAAAACAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011699380.1\|3124930_3125839_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|224629
NC_008554.1\|WP_011699378.1\|3122391_3123885_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|226608
NC_008554.1\|WP_011699375.1\|3118034_3118607_-\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|274058
NC_008554.1\|WP_041440511.1\|3142980_3145041_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NC_008554.1\|WP_041440509.1\|3140777_3141701_+\|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|308985
NC_008554.1\|WP_011699387.1\|3136780_3138325_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|366133
NC_008554.1\|WP_011699389.1\|3139529_3139787_+\|DUF504-domain-containing-protein	unknown	unknown	gnl\|CDD\|367951
NC_008554.1\|WP_011699379.1\|3123863_3124874_+\|type-II-restriction-endonuclease-BsuBI	unknown	unknown	gnl\|CDD\|377679
NC_008554.1\|WP_011699373.1\|3114028_3116686_-\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_008554.1\|WP_011699377.1\|3120049_3121216_-\|nickel-pincer-cofactor-biosynthesis-protein-LarC	unknown	unknown	gnl\|CDD\|376691
NC_008554.1\|WP_011699376.1\|3118581_3119856_-\|CinA-family-nicotinamide-mononucleotide-deamidase-related-protein	unknown	unknown	gnl\|CDD\|234789
NC_008554.1\|WP_011699381.1\|3126171_3128184_-\|DUF1566-domain-containing-protein	unknown	unknown	gnl\|CDD\|377878
NC_008554.1\|WP_011699388.1\|3138418_3139477_+\|RNA-3'-terminal-phosphate-cyclase	unknown	unknown	gnl\|CDD\|235255
NC_008554.1\|WP_011699384.1\|3134855_3135284_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_008554.1\|WP_150109516.1\|3128921_3131171_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_008554.1\|WP_011699392.1\|3141804_3142668_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_008554.1\|WP_011699390.1\|3139971_3140229_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NC_008554.1\|WP_011699383.1\|3131891_3134444_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_008554.1\|WP_011699374.1\|3116821_3117853_-\|recombinase-RecA	unknown	unknown	gnl\|CDD\|236476
NC_008554.1\|WP_049766373.1\|3135707_3136496_+\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl\|CDD\|223704

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011699380.1\|3124930_3125839_+\|restriction-endonuclease	gnl\|CDD\|224629	COG1715, Mrr, Restriction endonuclease [Defense mechanisms].	2.06698e-129
NC_008554.1\|WP_011699378.1\|3122391_3123885_+\|SAM-dependent-methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	2.36285e-07
NC_008554.1\|WP_011699375.1\|3118034_3118607_-\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|274058	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase. This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing].	2.18731e-44
NC_008554.1\|WP_041440511.1\|3142980_3145041_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NC_008554.1\|WP_041440509.1\|3140777_3141701_+\|YkgJ-family-cysteine-cluster-protein	gnl\|CDD\|308985	pfam03692, CxxCxxCC, Putative zinc- or iron-chelating domain. This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	6.72759e-09
NC_008554.1\|WP_011699387.1\|3136780_3138325_+\|FHA-domain-containing-protein	gnl\|CDD\|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	2.95042e-15
NC_008554.1\|WP_011699389.1\|3139529_3139787_+\|DUF504-domain-containing-protein	gnl\|CDD\|367951	pfam04457, DUF504, Protein of unknown function (DUF504). Family of uncharacterized proteins.	6.10983e-22
NC_008554.1\|WP_011699379.1\|3123863_3124874_+\|type-II-restriction-endonuclease-BsuBI	gnl\|CDD\|377679	pfam06616, BsuBI_PstI_RE, BsuBI/PstI restriction endonuclease C-terminus. This family represents the C-terminus of bacterial enzymes similar to type II restriction endonucleases BsuBI and PstI (EC:3.1.21.4). The enzymes of the BsuBI restriction/modification (R/M) system recognize the target sequence 5'CTGCAG and are functionally identical with those of the PstI R/M system.	8.84223e-90
NC_008554.1\|WP_011699373.1\|3114028_3116686_-\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_008554.1\|WP_011699377.1\|3120049_3121216_-\|nickel-pincer-cofactor-biosynthesis-protein-LarC	gnl\|CDD\|376691	pfam01969, DUF111, Protein of unknown function DUF111. This prokaryotic family has no known function.	0
NC_008554.1\|WP_011699376.1\|3118581_3119856_-\|CinA-family-nicotinamide-mononucleotide-deamidase-related-protein	gnl\|CDD\|234789	PRK00549, PRK00549, competence damage-inducible protein A; Provisional.	1.02352e-111
NC_008554.1\|WP_011699381.1\|3126171_3128184_-\|DUF1566-domain-containing-protein	gnl\|CDD\|377878	pfam07603, DUF1566, Protein of unknown function (DUF1566). These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	8.49339e-36
NC_008554.1\|WP_011699388.1\|3138418_3139477_+\|RNA-3'-terminal-phosphate-cyclase	gnl\|CDD\|235255	PRK04204, PRK04204, RNA 3'-terminal phosphate cyclase.	5.65461e-162
NC_008554.1\|WP_011699384.1\|3134855_3135284_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	3.55669e-05
NC_008554.1\|WP_150109516.1\|3128921_3131171_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.32899e-108
NC_008554.1\|WP_011699392.1\|3141804_3142668_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	9.77244e-19
NC_008554.1\|WP_011699390.1\|3139971_3140229_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	2.33382e-12
NC_008554.1\|WP_011699383.1\|3131891_3134444_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.44213e-109
NC_008554.1\|WP_011699374.1\|3116821_3117853_-\|recombinase-RecA	gnl\|CDD\|236476	PRK09354, recA, recombinase A; Provisional.	0
NC_008554.1\|WP_049766373.1\|3135707_3136496_+\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	1.39227e-72

>NC_008554.1|WP_150109516.1|3128921_3131171_+|protein-kinase
MSMRKTDTLIGKQIDQFRLDQFIARGAMGAVFKAFDAVLARTIALKLIPKEIEEGLSEAEVFTREESKKRLIQEAKAAGRLAHPNIVTIHSYGETDEFQYICMEYVSGKTLTQVLSERKPLSEEEAVSIFVQVLSALEAANKEEIIHRDIKPANIMITDENRVKVMDFGIAKLPSLSMTVTGMVLGTPYYMSPEQIAGKKVDIRSDIFSVGTVLYEVMTGEKPFVGESTATITYKIMALDPTPPAVINRNLSQPMADIIVKALAKNPDQRFQTPTEMMLALRALVQRPHAYPDDATLAGTVIGEPDFDQTVRAEIPEAVKSAARIGSVRPPGPRPPEPAPPRRISLDPRKPAEREPLRSDGTGARVSPSPGPGEEQTDIPVLTLTQGPAGKRGVKMKGLGIALLTILVALAGFLVYRSLRSPGVPSPRPSIPPPTSRSAPVTTRATQPPPTPTTAPPATIPPATSMPPLDQLTPGKDKTTASVEPLLVEAQNQSASNPAEAQKLLEEALRLDPNRFETILTMARLQASRKDYSAAVQYYRDAVRVNGNAPEAYSEMGALQQAQGDYASAIRSYEAGLALRPSHPDELLANVAFCHDKLNNPDQARRYYEQALEINPNNRAALAFLDSLSPATTQPKTPIASPRAPDTDSPSRAVRVEGKYNVEGQNPNGTSYHGTATIKRSVSGYTVTWNVGGKSYTGSGPLVGRTLTVKWRGSRGATGAVVYTVTATGVLKGVWGPNSSGLETLTPIN
>NC_008554.1|WP_011699381.1|3126171_3128184_-|DUF1566-domain-containing-protein
MCRNAKMSILVVLLSIMFVAVNVRAEVIQLPKTNQKKCYATGGAEISCAGTGQDGEIRAGVAWPGTRFKNNGDNTQTDRLTGLTWPVVVDPEIAGVCDSAVTNWAEALARVACLNAHSFLGYQDWRLPNVNEYESLRNGAESEVAGWLNSQGFFFAVEEPFLTSTSNAANTYYKWTVLLAGGNAVTLLSESQGFPSPVWPVRGGQSGAPSSVYPANVWKTGQTASYAAGDDGALEKGVKWPVPRFKATAFTGGVRDDLTGLVWTRNANAPGPAACGPGTAKTWQGALNYVQCLNANNFLGFSDWRLPNRVELHSLTDFSRRNPALPAVHPFINVKNAKYWSSTSNVDLPDQAVVVHMGNGRILYNSKNASGLQRVWPVRSGIVIDTPPLKLSATAISSSAITLSWNDGTTLESGYRVETKEGSCSSGSAWTPIATTGPNVVQYTRSGLVADSTHSYRVRAYNAHGYSAYSNCAFATTGPSGAPASPSDLKAYSRGPNKIDVYWKDNSSNETNFFLYRRDCLSCPWDTRATLMPGAETFSDGTATGNEASAVYSYYLIACNGAACSPATRVAAVPLKPTGLNANPVDFVNLTWTDSSSNETGFQVYRKEALCADAASWVLKTTTAPNVHVYLDNSVISGTFAYHVRAFHESDGEPNAYGYSNWSNCAEAVK
>NC_008554.1|WP_011699380.1|3124930_3125839_+|restriction-endonuclease
MAIPDYESIMLPLLRFAGDGKEHSAKEAAQALAVEFALSESELKQLLPSGRQTTFGNRIGWAGTYLKKAGLLQSSRRGIFQITARGLQLLAEKPIQLNSASLHRFPGFVEFIEARKGKAAIPSDDDPINRETPEEVIEAAYQRIRQDLASELLQTIKNCSATFFERLVVDLIVKMGYGGTRKDAGEAIGKSGDEGIDGIIKEDRLGLDIVYIQAKRWDSQVGRPEVQKFAGALQGQRAKKGIFLTTSAFTKEARDYVSRIESKIVLIDGDLLAQLMIDFNIGVAAVASYELKRIDSDYFTEE
>NC_008554.1|WP_011699379.1|3123863_3124874_+|type-II-restriction-endonuclease-BsuBI
MRKKDNIESALEILAALGLPRAQQNERSALCLLALLNLIPGKAWAHSENPLIGITPMMKFSGKYYGREYAPNTRETFRRQTIHQFLQAGVACYNPDRPDRPVNSPKAVYQISPEALALLKTYGTNKWRAFLKRFLAIRKTLAQRYANERVQKLISVRVAVDQKIRISPGEHSELIKAIIESFAPRHAPGCRLVYVGDTGEKWGYFDEKLLADLGVTIDSHGKMPDVVLFYPEKHWLLLVESVTSHGPVDSKRHTELAVLFADSSAGLVYVTAFPSRAVMQRYLSEIAWETEVWIADAPSHLIHFNGPRFLGPYDGKLGEKPKLADKGHLLPEYKTN
>NC_008554.1|WP_011699378.1|3122391_3123885_+|SAM-dependent-methyltransferase
MLKLLEHADSVRKEVGRHISQEHKSDLGQFMTPATVARFMASLFSSSTLSTGRVLDAGAGVGSLSGAFLDRVVRGGFAFRRVEVTAFEIDARLRNHLSRTLANYHGEFTLDASVVAGDFIEEAVQMILNGGPCFTHAILNPPYKKINSASRHRSLLRQVGIETVNLYSAFVALAVRLMQPGGQIVAIIPRSFCNGPYYRPFRELILARTAIKHIHLFDARDRAFKDDDVLQENIIILLERDARQGIVTVTTSTDDRFFDIRSHDYPFGRIVFQDDPEHFIHIPTSPEQNQIECSPLISCSLADTGLEVSTGPVVDFRLRAHLRKMPEKGTVPLLYPCHFSGYVVDWPKSGAKKPNAILRNPETERWLYPNGCYVVVKRFSSKEEKRRIVASVVYPDAFDSPVLGLENHLNVFHRGRQGLPEDLARGLSVFLNSTQIDEQFRRFSGHTQVNATDLRLLKYPSREVLTRLGLWAKAQGLLTQDGIDKKIESLACGKKTI
>NC_008554.1|WP_011699377.1|3120049_3121216_-|nickel-pincer-cofactor-biosynthesis-protein-LarC
MKTAYFDCFSGISGDMVLGALLDLGLPLDVLSGELKKIAVSGYVLSAERERRGSIAGTRVRIDIEDQPARSYREIARLIGESALESPVKEKSLAVFEKLALAEARVHQVPPGDVHFHEVGALDSILDIVGAAIGLHHLGIERLCASRVPLGGGFVETRHGLLPLPAPATVLLLEGVPVYDNGIQRELTTPTGAAILAALAESFGPVPDMVVRSTGYGVGTHPCADPPNLLRVLVGEASPGLLRRRLLLIETSIDDMNPEFYGHVMERLFDAGALDVNLVPAQMKKNRPAVILRVLLEPALQAAVTEIVFRETTSLGVRIQEVDRVELPREIGEVDTPYGRCRVKWVRTPWGERRATPEYEDCKRIALEQGVPIRRIYEEVLAAAGRGQ
>NC_008554.1|WP_011699376.1|3118581_3119856_-|CinA-family-nicotinamide-mononucleotide-deamidase-related-protein
MDERPPEISGSLLTIGDEILLGDILNGNARHIALELRNRGFRLDRMITVGDREEDIVSSLVLCLADARFIIVTGGLGPTDDDRTNAAVSRAFDRPLVADEAYVGRLKERLAERGQAWSNEVAKMAELPAGAVKIGLDMAGFFIDHGNVPCYFLPGVPGEMKFLLAEVVIPDLARRFPLRGAYLKEVVRVQGMVESEVNRRLRDLDCRRIGVEIGYLPQGSENWVTLFAVAASEEECRTRIEKVREEVVARLGEKHISGRNDECLEKVVGERLRERGWRMAAAESCTGGLLSTRLTSIAGSSDYFDRAFITYSNQAKQDHLGVSEEMLRVHGAVSEPVALAMAEGACRGARVEVALGITGIAGPAGGSAEKPVGTVCIACVTPKEKRVEKHRFEGVRESIRQSAAQAALLLLWRVLTDDSNLHCR
>NC_008554.1|WP_011699375.1|3118034_3118607_-|RNA-2',3'-cyclic-phosphodiesterase
MIRTFIAVDLPSPVQAVLERFERELRKADATVAWIRPDRIHLTLKFLGNVAPERIPALREALESVSRTVSPFRLQAAGCGAFPTIRQMRVIWVGLRGDADRLGDLKQKIEAATVPLGFESEDRPFKPHLTLGRVKGRGRLSVLQEILMANQSFEAEAFDVAEVVLYKSDLKPDGAQYTPLFRAPFTGRPE
>NC_008554.1|WP_011699374.1|3116821_3117853_-|recombinase-RecA
MGAVDERQRAIDTAVSQIERMCGKGAIMRLGEGAQNVEIPVISTGCLSLDLALGIGGVARGRIMEIFGPESSGKTTLALHVVAEAQKLGGLAAFIDAEHALDVNYARKLGVQVEDLLISQPDYGEQALEIAEILVRSNAIDVIVVDSVAALVPKAEIEGEMGDPHVGLQARLMSQALRKLVSSISKSRTCVIFINQIRMKIGVMYGSPETTTGGNALKFYATMRLDIRRVGPIKDGQEVVGNRTRVKVVKNKIAPPFREVEFDVVYGRGISREGDILDLAVESGAIEKSGTWYSYSGERLGQGRENAKNFLREHPDLLGELERKLREAHNLRFSPGPVTGAGE
>NC_008554.1|WP_011699373.1|3114028_3116686_-|alanine--tRNA-ligase
MKASEIRKAFLDFFAQRGHSVVKSSSVIPHDDPSLLFTNAGMVQFKRTFLGEEKRPYNRAATSQKCMRAGGKHNDLENVGRTARHHTFFEMLGNFSFGDYFKEDAVEYAWRFLTEDMGLPREKLYATIHEGDSEMRLGPDEEARGFWARYLPADRILTFPTKDNFWSMGDTGPCGPCSEILIDQGAHVGCGKPDCRPGCDCDRFLELWNLVFMQFNRKEDGTMEPLPKPSIDTGMGLERVAAVIQKVPSNYDTDLFAPMRAKIAELSGYRYGTDPEKDVSVKVIADHGRAAAFLIGDGALPSNEGRGYVLRRVLRRALRHGRFLGLDRPFLSEVAVAVMESMQDAYPELLESRNFITRVILNEEERFNETLDNGLRLLQNEIRRLRDEGAGTIPGALIFKLYDTYGFPIDIITDMARDLDFKVDEAGFADLMEKQKEQSRMHWKGSGEREVSEAYRQLSAEGVSTRFVGYDTLSAQSTIAALVRDGQAVEEAPAGTDVEVVTSETPFYGAAGGQVGDQGVIVGPSSRVIVSDTLKLPGDLIVHVGKVESGRLRVGETVRLEVDQALRGDTALHHTATHLLHSVLRRVLGDHVKQAGSMVAPDRLRFDFTHFAAISRDELAEIERLVNEQIRVNRDLQVREMNLDEALKTGAMALFEEKYGDRVRMVEIPGFSRELCGGTHTHRTGDIGLFVVTQEMSIASGVRRIEALAGRRALDYLGRQQSVLHQAAGLLKAGPFEVAERVEKLLANQKQMEKELEALKSSLTSKRSADLLEQAEEVGGVKVLVMRVEADDPKALREMNDRFKERLSSGVTVLGAHQGDKAFLLVGVTPDLTSRVHAGNLIKEIVKTIGGSGGGRPDMAQAGGNRPEKLQDALDLARKLLRERL
>NC_008554.1|WP_011699383.1|3131891_3134444_+|serine/threonine-protein-kinase
MINPESLVGRQIDQFRLDQYLARGAMGLVFRAFDTVLVRTVALKLIPKAIEEGLSKEELAAREEARKRLIQEAKAAGRLTHPNIVTIHSYGESEEFEYICMEFVTGETLAHMLRERKAVPIEDAIPIVEQILLALQTANQEKIVHRDIKPSNVMVTLDKRVKVMDFGIAKLPSLSMTITGTVLGTPYYMSPEQISGQKVDIRSDIFSLGAVFYEMLTGERPFEAENTATLAYKIVQVEPIPPKVLNIHIPSTVGSIISKALAKDPTLRYQAPSEMLRDLRALKEQLASGKTHHSAATAPGAVREPERANEPPKAAPGGAAETCPPVPSAQAAKQPAAIRPPESPPAAPTPAVKTVKKETDVSAPTPAAAPPPPPAQGSPPGKEHPADVEAKSPLPVGMKAAEEARSGSTATQPASLKRKTGGLPGLSVGRKKPSNALRLVPVGAAALLLVVVGFVFMSRDSARPPQAAGPSAKTAQNAAPAAKTQPQKVPAAKPAPEAAPIDGRETRMKADTLVLQARNVWQANPVGAQKILEEAIGLDPNNFEAYLHLARLMTQKKDYANALQHYQNALRINNRAAEVYFNMGFIFLMQGDYDAAMTHYEACRALNPPYQDEVLTNLGMCHLKKKNPAQALELFRQALDLNPSNSVAKSYLAGLPAPTQDASPGQDPPGPASAASTAAQSGSPGGEQAGQSADALVLEAKDQMQSDPARAQKLLEDAVGMDPNHFDAIFQLARLLTLKKDYAAAAQYYLAALRINQKSAEVFFNLGYIYLNQGDYDQAQANYESCLALSPAYKDEILTNLGIVHLKKDNPAEARSMFRRALDANPRNRLAQNHLNNLTKQAAKGSAGKP
>NC_008554.1|WP_011699384.1|3134855_3135284_+|LysM-peptidoglycan-binding-domain-containing-protein
MSKALRIVLLIPVIAALFFCGCATTDQSAKQESAAAPPPAVEEPEFISHKVYAGETMASIAKWYTGKESKWREIAEDNPGLNPKALKQGDLVKVRVSLATAHTAQPSHSTRPRKAAKKKAARPGTVEEDSSAPSEDEVFGPK
>NC_008554.1|WP_049766373.1|3135707_3136496_+|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MNTKSCSSSARKRQGERVFKIACHGKSDVGLKRTNNEDSFAVEQNLGVAVLADGMGGAAAGELASRFFTRAALEVFSSADSNDDSNNPDPIERTFTLANRKILDHVKENPEHRGMGCTAELLAFKGPRYCLGHVGDSRTYLFRNGQLTQLTRDHSFVQDLLDKGVITPEEARVHRFRHVILRAVGTSESLSVDVMRGEVASGDLFLQCSDGLTDMVEDDLIVQILATGDPLGVKAEKLISAANAAGGYDNVTVVLSEVVPVV
>NC_008554.1|WP_011699387.1|3136780_3138325_+|FHA-domain-containing-protein
MITSFFLQEEGSRVIHRVSLPCVMGREEGVDLRFADPTVSHRHALISEENDHIWIDDLGSLNGIYVNDVRIEDKAPLKPGDTIRLGRLTFSVCRSYEEVAGDTIAFPSLHTMGDRRLDRQRLKWIYEITVELSEKQDPALLGERFFSRLKDIYQQDQGYLGVFKEDGSLESVFSDASLDSVPVSRSIVDRLLQNGESFILEDALGGEALNKDAAALEMKIRSALCVPLLYHNQIHGLIYLSRSVPGAYSHEDLEFLRTVSCVLAPMVENARLWAEIKGLYASTVDSLKETQSRLIEVERAAAYARLAQAMAHEIRNPLMVIGGMVRRMRRPAPDEPEGAGMQAVMSSVERIETVLREVDGFVKLPPPTKQLRKIDSLILEEIRQHDRDWKEKDIRPQLVVGTSHLMIPIDDTLFRKALSLIFRESLSNVPRGSELSISIRDRGGELEIEIGRRADRTVYCEAFDPALQHKPWVLDLFLNMGHKIIADQDGKLLLDRHSSSVFPMVIRLPRIVKP
>NC_008554.1|WP_011699388.1|3138418_3139477_+|RNA-3'-terminal-phosphate-cyclase
MDEPITIDGSMGEGGGQVLRTSLALSMSTGRPFRIVNIRARRKHGGLLRQHLTALNAAAEVSRARVDGAVPGSVEVTFEPRNVLPGSYRFSVGTAGSATLVLQTVLPALATASAKSRLVLEGGTHNPWAPPFDFLERTFIPFLKRMGPDVSCQLERPGFYPAGGGRFIVEVSPVARLSRVSLLHRGAIRRSGCRAVVAHLDMNIGHREVGAVCRGLGWSPDWAEVTACPESTGPGNVLIVAIESEHITEIFTGFGARGVPAERVAAGTVEEVRRYLAAGVPVGVHLADQILPLLALGGGGSFRTVAPSPHTMTNIDVIERFLDVRIECARIADDIWEITVEHARGLDSGTQA
>NC_008554.1|WP_011699389.1|3139529_3139787_+|DUF504-domain-containing-protein
MVTIRDLLNRIRWDREFGAGFFELGYLDHVEHAIVRVPFRNIFFEEGDSFSFHLEKETGETLTIPLHRVREVYRNGIRIWQRPGG
>NC_008554.1|WP_011699390.1|3139971_3140229_-|zinc-ribbon-domain-containing-protein
MPIYEFRCTKCGHIREFIMTGSDREIDMKCEECGGDDLERVMSSVNYAMGSSGSSSGRDSSPSATTRTCAPGKSCTTLKLPGHTK
>NC_008554.1|WP_041440509.1|3140777_3141701_+|YkgJ-family-cysteine-cluster-protein
MSETEQNQTIIDSHPTEWDEADFRRNWSQFLQMLVGENENALPLKRIQYQVEQSPIYKEVLVRWSGLSGAERLGAWKRLLQAAEEVSREVLPACVQCGTCCRKGSPSLQLEDLELLQTGRIPWNQLVTLRRGEPVQSPFDRKPFFLLDERIKIRERADSQECVFFNADTCLCAIYADRPVQCRAQACWDPAPAQDLAKQPYLTRRDIFKNVDLLLEIIVEHDKRCSFRKLNDAFDRLIETKGETVGEVLEILSYEEHFRNFIGEKLKVPSGQVELVFGRSLTDLVPLFGFRVIEEPDGSRCLVPETA
>NC_008554.1|WP_011699392.1|3141804_3142668_-|flavodoxin-family-protein
MSSSSILLGIIGSPRKHGNSEILVKEIYRQLSGDWELRLMRLPEMDIRPCRACYQCLFGEMKCIQDDDFHIALDALLECSAYAVVSPAYLLDANAGLKRFLDRGLAFYGHVAALWGKPAVAAAIAGIEGMEGRTKLAVEGFVKFTMGDLRGSTVLYGALPGEVLLGERGRSEARRLAQAIEKPGKEERVAGVPACSVCGADSFRFLPDGRVRCLLCSSTGSCEWREGRLTVATQPGDHPFFHTRESVLEHAEWLRGMKDRFLQRRKELKAVVQDYAGVGTWIKPDRK
>NC_008554.1|WP_041440511.1|3142980_3145041_-|thioredoxin-domain-containing-protein
MLMPNRLSAEKSPYLLQHADNPVDWYPWGEEAFRKAKEEDKPVFLSIGYATCHWCHVMERESFEDEEVAALLNEHVVAVKVDREERPDIDQIYMTVCQALLGSGGWPLSVFMTPEKNAFFAGSYFPKHARLGMAGFTDVIRRIVHMWKNDRERLLEAGRQITESIQPRPVQTVGSLPGPEVLEEAYSRLSRAFDATWGGFGSKPKFPTPHHLTFLLRWHRRNPWSDALAIVEKTLDGMRDGGIFDQVGFGFHRYSVDEKWLVPHFEKMLYDQAMLALAYLEAFQVTGRERHGRVAREIFEYVLRDMTDPDGGFYSAEDADSEGVEGRFYVWTPAEVNALLGNEIGETFCRFFDITPEGNFEDGRSIPHLAELADSLSDRDEPGIGGLEDLLEKGRRLLFEARRMRVHPLKDDKILTSWNGLMIAALSKGSRALGDRSYALAASRAADFILDRMRRDSGRLHRRYRKGEAAIHAYADDYAFFIWGLIELYEAAFDVRYLEEAVKLQDLMIDLFWDDAEGGFFFTPNDGENLIVREREIYDGAVPSSNSAAALNLLRLGRMVGAVRFEEKADRLLRRFSETVRDYPSAYTQFLHAVDFAAGPTREVVIAGSPDNATTAEMMKIVGSGFVPNTVVLLRGTPESGARLAELAPYTAGLVAPGGNPAVYICEKFACTSPITEIEELRETFG

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Crispr_ID: NC_008554_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_18

3478585-3478736

TypeI-E

Consensus_repeat	Method
GTCTCTCGCGCCTGCGCGTGGACCGAAAAC	PILER-CR

2 spacers

WYL,cas3,cas8e,cse2gr11,cas7,cas6e,cas1,cas2

The CRISPR arrays of NC_008554_18

>merge|NC_008554|18|3478585-3478736|PILER-CR
GTCTCTCGCGCCTGCGCGTGGACCGAAAGCTCCCCAACGTCCACGAAGAGCCGCGCGGGAAGTCTCTCGCGCCTGCGCGTGGACCGAAAACGCTTCAGTACAAAGTCCAAAGACTCGCACTAAACTCTCGCGCCTGCGCGTGGACCGAAAAC

>NC_008554|18|3|3478585-3478736|PILER-CR
GTCTCTCGCGCCTGCGCGTGGACCGAAAGC	TCCCCAACGTCCACGAAGAGCCGCGCGGGAA
GTCTCTCGCGCCTGCGCGTGGACCGAAAAC	GCTTCAGTACAAAGTCCAAAGACTCGCACTA
AACTCTCGCGCCTGCGCGTGGACCGAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011699675.1\|3487708_3488629_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_008554.1\|WP_041440642.1\|3468707_3469019_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011699659.1\|3469002_3470136_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NC_008554.1\|WP_011699663.1\|3471958_3472948_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011699671.1\|3484753_3485233_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl\|CDD\|187862
NC_008554.1\|WP_011697013.1\|3494179_3494959_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NC_008554.1\|WP_041439521.1\|3494955_3496206_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NC_008554.1\|WP_011699670.1\|3483196_3484750_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_008554.1\|WP_041440647.1\|3471287_3471962_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_008554.1\|WP_011699674.1\|3487097_3487706_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|187858
NC_008554.1\|WP_011699660.1\|3470178_3470703_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377526
NC_008554.1\|WP_011699668.1\|3479428_3480433_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_008554.1\|WP_011699666.1\|3474240_3475392_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|273178
NC_008554.1\|WP_011699665.1\|3473825_3474203_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|224350
NC_008554.1\|WP_041440645.1\|3470718_3471183_+\|nitrous-oxide-reductase-accessory-protein-NosL	unknown	unknown	gnl\|CDD\|377526
NC_008554.1\|WP_011699676.1\|3488609_3488972_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|236930
NC_008554.1\|WP_011699667.1\|3475391_3478454_+\|SMC-family-ATPase	unknown	unknown	gnl\|CDD\|223496
NC_008554.1\|WP_011699672.1\|3485267_3486422_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_008554.1\|WP_011699664.1\|3473056_3473527_+\|DUF134-domain-containing-protein	unknown	unknown	gnl\|CDD\|224261
NC_008554.1\|WP_011699669.1\|3480614_3483179_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_041440647.1\|3471287_3471962_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.52505e-89
NC_008554.1\|WP_011699659.1\|3469002_3470136_+\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	1.32993e-15
NC_008554.1\|WP_011699664.1\|3473056_3473527_+\|DUF134-domain-containing-protein	gnl\|CDD\|224261	COG1342, COG1342, Predicted DNA-binding proteins [General function prediction only].	2.18455e-31
NC_008554.1\|WP_011699671.1\|3484753_3485233_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|187862	cd09731, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	4.14634e-34
NC_008554.1\|WP_011697013.1\|3494179_3494959_-\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	7.26787e-95
NC_008554.1\|WP_041439521.1\|3494955_3496206_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.37847e-42
NC_008554.1\|WP_011699669.1\|3480614_3483179_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	5.2833e-115
NC_008554.1\|WP_011699666.1\|3474240_3475392_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|273178	TIGR00619, Nuclease_SbcCD_subunit_D, exonuclease SbcD. All proteins in this family for which functions are known are double-stranded DNA exonuclease (as part of a complex with SbcC homologs). This complex functions in the initiation of recombination and recombinational repair and is particularly important in regulating the stability of DNA sections that can form secondary structures. This family is likely homologous to the MRE11 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.78615e-51
NC_008554.1\|WP_011699674.1\|3487097_3487706_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.40538e-63
NC_008554.1\|WP_011699660.1\|3470178_3470703_+\|hypothetical-protein	gnl\|CDD\|377526	pfam05573, NosL, NosL. NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallo-centre assembly.	2.85248e-11
NC_008554.1\|WP_011699668.1\|3479428_3480433_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.26872e-44
NC_008554.1\|WP_011699665.1\|3473825_3474203_+\|diguanylate-cyclase	gnl\|CDD\|224350	COG1433, COG1433, Uncharacterized conserved protein [Function unknown].	5.20002e-21
NC_008554.1\|WP_041440645.1\|3470718_3471183_+\|nitrous-oxide-reductase-accessory-protein-NosL	gnl\|CDD\|377526	pfam05573, NosL, NosL. NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallo-centre assembly.	2.40797e-40
NC_008554.1\|WP_011699676.1\|3488609_3488972_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	5.4419e-63
NC_008554.1\|WP_011699667.1\|3475391_3478454_+\|SMC-family-ATPase	gnl\|CDD\|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	3.04781e-76
NC_008554.1\|WP_011699672.1\|3485267_3486422_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	3.78385e-131
NC_008554.1\|WP_011699670.1\|3483196_3484750_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	3.40019e-121
NC_008554.1\|WP_011699675.1\|3487708_3488629_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	1.56135e-149

>NC_008554.1|WP_011699667.1|3475391_3478454_+|SMC-family-ATPase
MRPLKLTLSAFGPYASEQVFDFRVLGDRSFFLIHGPTGSGKSTLLDAVCFALYGETSGGERDVRHLRSDYARASTPTRVTFDFSLGEAVYRITRSPEQERPRARGEGTVVQRPAAVLHDRTGLVDESREGALLAGQWTRVTDRMEQLLGFKSSQFRQVVMLPQGQFRKFLTADSRERQAILEVLFQTEIYRRIEEAVKEAAREIQHALEDLGKRRRLILEQAAVESERQLAEAMEGFAARLEALGGQVEALKKSEALANEAVNKGREIRRILDEAARAQAEFAALEKRKPEIEDRRVKLDRARKAAGLRGVEANLAAREKEFGDASVRVRTAEIEIEKARAARQAAEAALAGEREREGEREAARRDVVQLTAMIDQVRELEAARSDLGGMKARVERVERLRGLRAAALERCRIEMAEAGAALEETEAQAVHAERYRLEVRQAAASYRATIRLKTSEKHLALALAHRKKTEAAAGTALAVLTDARTALDGMEREWLEGQAAILAGRLADGLPCPVCGATDHPSPARHGGELPTEAAHKKARTHARELESRYEKARLESERANLEVAALQSAAANLRAEAGEVPAEGFRDLKTRLRDAWARFRTAVAARAQVTDRAVALKAVEERTAGNEKRLRRLENGLRAAVRRMDGQAAVMAEREGKVPDRLRDLKALERAISTAQKRLRSLLDAQEAARARQEAAAARAAACEETLRNAVEALESAKERAGSCREELRLRLAEEGFSSVEDYRAAKLDRKDVDRMEREIADFHGRHRAARERLDRAVAAAQGLETPVLEELERKAREASEALRSAIARHGALRAQSDQLARWNADLHKLAGEMEAAQNRYGIVGRISEVANGKNAPGLTFQRFVLAALLDDVLDAASRRLRRMSRGRFDLQRSRERGDQRAAAGLDLAVYDTYTGTTRPVNTLSGGESFLSSLAMALGLADVVRAYAGGIRLETIFVDEGFGSLDQESLDLAFQTLVDLQEGNRLVGIISHVPELRERVDARLEVIPGIRGSDARFVL
>NC_008554.1|WP_011699666.1|3474240_3475392_+|exonuclease-SbcCD-subunit-D
MRILHTADWHLGRIFHGVHLTADQAFVLDRLVRLASESKPDVVLVSGDVYDRAVPPPDAVALLDDTLSRLVLGLRIPVILIAGNHDSPERLSFGSKVLAAQCLHLAGTPAPDATPVVIDDRHGPVSFCSLPYAEPALVRERLDRKDVVDHDSAMAAQIESARRRLPAGSRAVLVAHAFVAGGIESESERSLSVGGAAAVGVEHFEGFHYAALGHLHRPQRAGADHVQYAGSLLCYSFAEAGQTKSVNLVELDAAGRCAVERIPLAPSHEVRCIRGAFRELLAGPRAAESREDYIMAVLTDKEPILDAHGRLSEIYPNLLHIERSHLAAAGETGGAARDHRRLSDLELFRAFFSQVTGDELTPEQAEAYAEIVENLRRAEREAD
>NC_008554.1|WP_011699665.1|3473825_3474203_+|diguanylate-cyclase
MKICFPTETLQGMDSMVYGHFGSAPGFVIVDTGTGSVEEIANGDLHHAHGMCQPFKALGGRRVDAIVVGGIGMGALMKLRADGIVVFRAVEGTVGENVELLNNRSLPQFQPEHTCAGHSGGGCAH
>NC_008554.1|WP_011699664.1|3473056_3473527_+|DUF134-domain-containing-protein
MPRPKCCRTITGEPPCRAFTPAGTTGPAPSRVVLSEDEFEAVRLADFEGLYQEEAAERMGVSRQTFGRIVGAARAKIARVLVEGLALSIGGGGGTGIAPSRSYMCRLCRHTWDMPSETDSPAECPACRGRNLFRCGASLETAASGRECCPRERKAT
>NC_008554.1|WP_011699663.1|3471958_3472948_+|hypothetical-protein
MIFHPTILALLAGSMLTCAMLVYSAFFGVRILRNWDITSGSEVQLEMERRTYLISTVMAYALGFQLLSLFLFLTAADHLATMFVGAMCAAGTLKVNDWGYPTLVFKVVNALLCGLWLIVNHADNSGYDYPLIKRKYALLLIVTLSVAVETVVQTAYFLGLDPDIITSCCGSLFTSGSETIAAGVLSLPELPVEIAYGAAVISTFASGLCFLFKEKGAYAFALTSGITFVVSILALITFISPYFYELPTHHCPFCILHGEYRYIGYPLYSAFLAGGVAGLGVGALMPFREVASLREILPRLLRRLTWTSLGAWLVSLAIVTWGIVFSNLK
>NC_008554.1|WP_041440647.1|3471287_3471962_+|ABC-transporter-ATP-binding-protein
MIRLDQVRKVFNIGKPNEFTAVDGVSLSLDSCRVTALRGPSGSGKTTLLSMMGCMARPTSGRIMLLDREITSLPERFLTEIRRKTFGFIFQQFNLIKGITVRENVMLPAYPTGEKSCVLGKRALDVLDLFNLSAKAASKVEWLSGGEAQRAAIARALMNDPAVIIADEPTAHLDTRLSREFMEMMGLLRQRGKTILIASHDPIVYDSAIVDRVVEMRDGKVVSP
>NC_008554.1|WP_041440645.1|3470718_3471183_+|nitrous-oxide-reductase-accessory-protein-NosL
MKYALISLAILLASLQAAAGDFVMPSSRDKCPVCGMFVAKYPDFVAEIVFKDGSRAFFDGAKDMLKYYFDLAKYNPSKKASDIESIYVTDYYSMRATDGRKALFVVGSNVYGPMGREFIPFANEEDANEFMRDHAGKTLVRFTDITPEMVKNQD
>NC_008554.1|WP_011699660.1|3470178_3470703_+|hypothetical-protein
MKVKMLIGLLALLVLLSGTPVPAQMDDDIAKHASCKYCGMDRQKFAHSRMLVEYEDGTVTGTCSIHCTAIDLAVNIDKTPKLIRVGDYGTKKLIDAESAAWVIGGDKPGVMTKQAKWAFANKEDAAKFAKESGGTEASFDMAMEASFRDMYTDTKMIREKRKMMKQKMQPEQKP
>NC_008554.1|WP_011699659.1|3469002_3470136_+|FtsX-like-permease-family-protein
MRHWIERQRNLLDFTLSSLLRRKGKNVALALIYTLVVFSLGSILLFTQAIRKEASLVLRDTPQILVQKLVAGRHDPIPLDYAGKIERIRGVTGVRGRLWGYYFDPATDANYTFMVPRDHSFKPGEVSIGSGVARGRSVREGDVLTLLASDGEPVIFRIRGIFSSESDLLSSDLILLSEDDFRSFFGVSGQYATDLIVEVANRKETTTVAGKIAQILPNTRPILRDEILRTYDAVFHWRAGLAFMILSGAVLAFVILAWDKATGLSAEEKREIGILKGIGWETSDILLMKFWEGMVISLSSFFVGILLAYLHVFLGSSALLEPILKGWSVLYPEFKLAPFVDFYQAATLFFLTVVPYTVTTVVPSWRAATIDPDLAMR
>NC_008554.1|WP_041440642.1|3468707_3469019_+|hypothetical-protein
MRKSDIFLAFMGVNAALSCLVWFHSHAGRSAALERIESRARLVRALELTDLCLFTEARYTRHPTQADRHAPFQDHPVSLEHFPTGSLIGPPQRMRKTNDAALD
>NC_008554.1|WP_011699668.1|3479428_3480433_+|WYL-domain-containing-protein
MKARFTQTRHRNLEETKRISRILELTRMILVNPRRYLRRDLSSRFEVSERMIQKDLEIIRHGLRLLLAHSPEGYYFEETPSLPPVRYSFSEALALLLAVQAARRLAGISSSDLAAAIARLESLFPAEFAPHLRAAAGAPGMRTGREHRQEMLRLLNLALIEGRKVRIVYETASRGGERNERVVCPYHLLSYVRSWHLIARCELREAVLVFKVDRISEAELLEHRYSIPRDFSVDDYLGMSWGMMRGGAQAPVDVALRFTPEAGRWVSEEHWHKSQRVEVEPDGHVLFRLHLPVTPEFVNWVLYYGSRVEVVTPESLREIVAEEHQRAAGLYGQS
>NC_008554.1|WP_011699669.1|3480614_3483179_+|CRISPR-associated-helicase/endonuclease-Cas3
MTEEDVFRFWGKTSGNVVHPAVCHMLDTGIVACELLMVQPHGFISKLADEFGITTDALPQLAAFLAALHDIGKISPGFQAKRPDLSAPLKLEGYVFSRADEDRHTLSTLETLPDLLIDCLQCEDSLAIALSRALAAHHGVFTGQEAQKVGAGKWIKARRAALEFLSRLFWDKSLTGLGFPSTPALVILAGLVSVSDWLSSAEENFPYLTCPRPDLREYVADRTQKARELVSRLRFDVSSPAATEFHQLFDFTSPNPSQTVTLQTVNELHHPMLVVIESPMGSGKTEAAQAVYAHLSCEAGLRGMYYALPTQATGNAMLPRTARFLTRLGLETGTELHLLHTNADLNQDYERLRISSLNAEPGDVSASSWFTARKRGLLAAHGVGTLDQALLAALKVRHFFVRLFGLAGKLLVLDEVHAYDAYMVEEIYRLIGWLAHCHTSVVLLSATLPKARRKKLIQAFRPEVEVPDDIRYPCVTGVDISGAFAAHPIEGLKPDTIYVEPVIAESTDKPARILSLLLEKLADGGCAACIMNTVGEAQDLHELLRHHFPADEVLLFHSRFTLERKLRIEHDILSRYASDGKRPHRGIVIATQVIEQSLDVDFDLMITDLAPIDLLLQRAGRLHRHERARPQLLRPRNLWVLMPEFRSRLPDFGGSEYVYTPDILLKTALLFSAEEDLSHLEVSIPTGVSALIECVYGDDFPPEVPEHLLGPMRGWEAKRLGDETSQTFFAACSALIEAKACLRDPDYLGQISMDNDDDCAIVTRLTRPNVMLVVVENGRCLTVADKAEERKLFSSTVATDNTAIVKHFLAKEPPGEWADSPLLRHCRPLFVSGGKSVERPDLSYDDEFGLRFAR
>NC_008554.1|WP_011699670.1|3483196_3484750_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MSAFSFNLIDRPWISCVELSGRRRTLGLHEVLSRAHELRGIELQSPLAETALFRVLLAAVHRIVEGPKGTGEWRALYQATKLPGGRIDAYFEKWSHRFDLFSKEEPFYQTPGLAIRDAKGAEAPAVIAGIMLERASGNNKTIFDHSMDEDRGCLSPEEAVLALIAAQMYSLRGLNKKTTNLFGYQESFSDSVMVGGIFAALQGQSLFESLLLNLLLYTDNLPIHSSRDDCPVWERHDHGETGVRTPRGYLDYLTCKCRHILLVPEPGLDGPCIRHVHIAQGEAFQDVDNPGFIKRKNKEGKWLPVQMQPARLVWRDSISLFSFDTGKREGDRRPDAFRLVGDIALRRIVALPSKYRCCTYGLANDQANPLAWRKETLNIPTALLSDPDLVACLREAMDLSEKAHTILRNAIRTYMDKYLPRNSRDVTEKLNATGASRLFWDRLESHFNAFLLEIENQDKALVAWERNIERAALEAFEACLKQRYADSAKKFRAWTEAHGQLVARLATLSKTLSRKGG
>NC_008554.1|WP_011699671.1|3484753_3485233_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MKSGENPFVAYLERLRDENDRAALAKLRRGLGKKMGTPEMYPFVVPFMPDDRRVREHYFLVASLFASHPDPAPIERSMGGVFKAILGKTESDSIEKRFVQLLSADIEDVGKYLRHAISLARSKGVAVNYHRLLSDLRYWEHRDRFVQLQWARDFWGFQK
>NC_008554.1|WP_011699672.1|3485267_3486422_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MFVDIHIIQNFAPSNLNRDDTNSPKDCEFGGYRRARISSQCIKRVVRSHRSFSQAVVHAGGDTGVRTKRIKSRLMDLFAKKYGKPEIVETEKVAETVIELLGLKLKDEEKTEYLLYLGENEAAQLARLAVDSWDALLAIEPEQDKKKKKGTGQESLKEFQEELKGIVGKRRKEARSYAADIALFGRMIADNKNMNVDAACQVAHAVSTNKVEMEMDYFTAVDDLLPGEETGSDMIGVVEFNSSCFYRYSNVNVSKLAENLGFNNDLTTAALLGYVEASVKSVPTGKQNSMAAQNPAGYARVIVRRDGFPWSLANAFQKPVRPSLDKSLEEASIDALERYFERLKAVYGTEGIVCDASFNLHRDDGGSLRKMLDALKACVAGEGS
>NC_008554.1|WP_011699674.1|3487097_3487706_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSLLSLDRLHRGTMRLLSDIYLLHKGIMSGFTRCGDGLRVLFRVEPENDDRIVRIMVQSDGSPSWELFTERHPCVIDMRTKVFSPALRAGHSYRFRLRANPAVKRNGKRYGLIRDETLEEWLRRKEPALGLQFRSVLALDEGYVTGHKEGSGHPQRINIKTARFEGILTVSEPHLVQNALCCGIGPAKAFGCGLLSLARV
>NC_008554.1|WP_011699675.1|3487708_3488629_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MQSQLPPLRPIPIKARVSVLFLEKGNLDVLDGAFVVVDKNGVRTHIPVGGVACLMLEPGTRVSHAAAVLASRVGCLLIWVGEAGVRLYASGQPGGARADRLLYQARLALDDTARLKVVRKMYAVRFGEEPPAHRSIEQLRAIEGSRVKNLYKLFAKQYGVPWHGRKYDPDEWGSGDTANRCLSAATACLYGVAEAAVLAAGYAPAVGFIHTGKPLSFVYDIADIFKFETVVPVAFKVAAQRSGEPERAVRIACRDAFRKSQLLTRIIPTIETILNAGGLNRPDPPEDSVPPAIPNKEQSGDAGHRG
>NC_008554.1|WP_011699676.1|3488609_3488972_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MLVIVVENAPARLRGRLAVWLLEIRAGVYVGDYSRRVREMIWKQVELGITEGNAVMAWSTNSESGFDFLTFGQNRRVPCELEGIKLVSFLPSNETEEQKCAISATNRELSEGHPNGNDSW
>NC_008554.1|WP_011697013.1|3494179_3494959_-|ATP-binding-protein
MSSTQLVRIQERLKHLKLYRINEQLESRLEEASRGNVSYGDFLDQLLDEEVSAKKEKNISMRTSMARFPFVKTLESFDFAFQPSIDKKRINELAACRFIANGENVILLGPPGVGKTHLAVALGIKAVTEGYRTHFTQAMPLVASLTKAYAENRIEERLKFYCQPKLLIIDEIGYIPIDRHGAHLFFQLISRRYERGALIVTSNRSFGQWNEIFGDTVIATAILDRILHHSTTVNIKGNSYRLKEKVKAGLLQSPELEQT
>NC_008554.1|WP_041439521.1|3494955_3496206_-|IS21-family-transposase
MVKRELWYEVQSRFKLKESKKSIARSLELSVQTVRSVLKQKAAPSYRRGPGKRTLLSPFEDHIHRRLAALGYCSRAIYEELVEQGYTGCYDTVRRFVQPLRKEAQTKATMRFETPPGRQAQVDWGQCWTLISGKRIKVHLFVMTLGYSRRLFAKATWDERLATFLACHEEAFEHFGGAAHELVYDNAKTVVVSRDVEGRNVKWNATFWDFSTYYGFRAWAHRPYRAQTKGKVESGVRYVKRFVRGKAFESMAHLNTLLGRWLATVADLRIHGTTHQRPIDLFEQERTLLLPTGAKPPYQVRERAVRYVARDCMVSFETNRYSVPLRFVGKPVEVQCANDRILIFHEGSLIVSHPCCTGKHQSLVDREHYTGIFYGIELPSVRMLAFDHALPLCSREEVEVRDLAFYERLAQEGGAS

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Crispr_ID: NC_008554_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_19

3489022-3493873

TypeI-E

I-B,III-A,III-B

Consensus_repeat	Method
GTGTTCCCCACGCGGGTGGGGATGAACCG	CRISPRCasFinder
GTGTTCCCCACGCGGGTGGGGATGAACCG	CRT
GTGTTCCCCACGCGGGTGGGGATGAACCG	PILER-CR

79 spacers

cas2,cas1,cas6e,cas7,cse2gr11,cas8e,cas3,WYL

The CRISPR arrays of NC_008554_19

>merge|NC_008554|19|3489022-3493873|CRISPRCasFinder,CRT,PILER-CR
GTGTTCCCCACGCGGGTGGGGATGAACCGTTCCTTCCTGCCATCCACTTGTCAACGTCCTCGTGTTCCCCACGCGGGTGGGGATGAACCGGCCATTCGCGTTTATCTCCTCATTGAAAGTGAGTGTTCCCCACGCGGGTGGGGATGAACCGGCATATCAACGCAAGGGGGGGAGCAAGTGAGAGTGTTCCCCACGCGGGTGGGGATGAACCGTACGGCTACGACCGGATTAATGACGCTGACGTCGTGTTCCCCACGCGGGTGGGGATGAACCGGCCGGAGCTCATCCGGGCCGCATCGGAAGTGCGTGTTCCCCACGCGGGTGGGGATGAACCGACGACTCACACCCCTTTAGCTTGAATGTCTCAGTGTTCCCCACGCGGGTGGGGATGAACCGCTTCCTGTCGGTCCATGGCTATGTCCACTCAAGTGTTCCCCACGCGGGTGGGGATGAACCGGTCTGGTTCGGTGGGGTGTGGTCTGGTCCGGTGTGTTCCCCACGCGGGTGGGGATGAACCGTTGTGGAGGCTGAAGTGGGCGACGACGGTAAAGTGTTCCCCACGCGGGTGGGGATGAACCGTTTCGTTCGGCATATTCGAGTTGCCTTGCGAGGTGTTCCCCACGCGGGTGGGGATGAACCGCAGTTTAACCAGTTGAGCAAATATTTTCCACGGTGTTCCCCACGCGGGTGGGGATGAACCGAGCTATTCCCCGGACCCCGCGAAAATCGAGGAGTGTTCCCCACGCGGGTGGGGATGAACCGTCCGATGAGCACGCAGGTATCAACCAGCGAGGGTGTTCCCCACGCGGGTGGGGATGAACCGTGGACAGGATGAAGAGCAGAACCTTCTGCCGGGTGTTCCCCACGCGGGTGGGGATGAACCAGCCAATGTGAACCGCATCTTTTTGATTCTATCGTGTTCCCCACGCGGGTGGGGATGAACCGGGAACCTCCCAGACACCCCGGCCAGTTTCCGGGTGTTCCCCACGCGGGTGGGGATGAACCGGCGGCCGTCCGGGGCACGGAAAATCTTCCCGGGTGTTCCCCACGCGGGTGGGGATGAACCGATCCTTGAGAACGTCCCTCGTGGTGGCGGTACGTGTTCCCCACGCGGGTGGGGATGAACCGATCCCTCAGCCATGGTTTGACGCCGAACACGAGTGTTCCCCACGCGGGTGGGGATGAACCGGCTCCCCGGCCCGGCGCAACGGAACGCCACGAGTGTTCCCCACGCGGGTGGGGATGAACCGGGACAGGATGCCCCATCAGGAAGGGCACCCAGGTGTTCCCCACGCGGGTGGGGATGAACCGTATGGCTACGACCGTATTAACGACGTGGATGTGTGTTCCCCACGCGGGTGGGGATGAACCGAGAACGCCCCGGCAAGGGGCACAACTAAGAAGGTGTTCCCCACGCGGGTGGGGATGAACCGTTGGGCTGTCCACTGTCTCTTCTCCGGGAAACGTGTTCCCCACGCGGGTGGGGATGAACCGTTCGTCATTCCATTGAATCCGAAGCTGCGGCTGTGTTCCCCACGCGGGTGGGGATGAACCGACGGTCGGCCAGCCAACAATATCCCCTTCGGTGTGTTCCCCACGCGGGTGGGGATGAACCGTGCTTGGCGATATGGAGGCAAAGATCGCCGGTGTGTTCCCCACGCGGGTGGGGATGAACCGCAGTGTTATTTCATTGCCTACGGGCAGGCGCTGTGTTCCCCACGCGGGTGGGGATGAACCGGGCGAACTACAAAAACCAACAGTAGGAGGATCGTGTTCCCCACGCGGGTGGGGATGAACCGAAAGACCGTGTGCCCTATGACCTGTGGGCGAAGTGTTCCCCACGCGGGTGGGGATGAACCGCCGGATTTCATCCGCACCGTTCCGAGATATGCGTGTTCCCCACGCGGGTGGGGATGAACCGTGCTTGGCGATATGGAGGCAAAGATCGCCGGTGTGTTCCCCACGCGGGTGGGGATGAACCGATCATCAATTCACGGGGAAAGTCCTTACCGTGGTGTTCCCCACGCGGGTGGGGATGAACCGACCACGTCCCAGGGGAACCCGGGGTTGTGGGTGTGTTCCCCACGCGGGTGGGGATGAACCGCTCCTGCGCGCAATCAGAGACCAGGCCGAGCAGTGTTCCCCACGCGGGTGGGGATGAACCGTCGAGCGATTTGGCCTGGAAGCAACCCCGGCAGTGTTCCCCACGCGGGTGGGGATGAACCGTTCATCCAAAACATTCCGTTGAGTGGCTTTCGGTGTTCCCCACGCGGGTGGGGATGAACCGTTGCCGTTCCGGGGATGAATCAATAATTCCGAGTGTTCCCCACGCGGGTGGGGATGAACCGGAACAAACAACCCAGATGTGCTGTTATGATGGGTGTTCCCCACGCGGGTGGGGATGAACCGATTGTTCGCTGCCACCCCAACCGCCACCACAAGTGTTCCCCACGCGGGTGGGGATGAACCGACGCCTTGGTATATATGGTCTGCTGCTTCGGGGTGTTCCCCACGCGGGTGGGGATGAACCGATTGTTCGCTGCCACCCCAACCGCCACCACAAGTGTTCCCCACGCGGGTGGGGATGAACCGACGCCTTGGTATATATGGTCTGCTGCTTCGGGGTGTTCCCCACGCGGGTGGGGATGAACCGCTGTCCTATCAGCACTACCTGGAGGAGAAGTGGTGTTCCCCACGCGGGTGGGGATGAACCGACGAGTAAAATAGATAGCCCTGGTCGGCTTGAGTGTTCCCCACGCGGGTGGGGATGAACCGCCCGTCTATCACCAGGGGCGGATTGTCGGGTAGTGTTCCCCACGCGGGTGGGGATGAACCGTAATCCGCGATGTGACGACCTGCGGAACAAGAGTGTTCCCCACGCGGGTGGGGATGAACCGGATGCCGTCGGGGTTCAAATTGGCGTCGCCGGGTGTTCCCCACGCGGGTGGGGATGAACCGTCCATTACGTCGCTAATAATCATTCTTCTCTTGTGTTCCCCACGCGGGTGGGGATGAACCGGACTGTATAGTTCCTCGACTTCAGATCCATCTGTGTTCCCCACGCGGGTGGGGATGAACCGGACTGTATAGTTCCTCGACTTCAGATCCATCTGTGTTCCCCACGCGGGTGGGGATGAACCGTCATGGCTGGCATCCAGATCTACCAGGAGCGGGTGTTCCCCACGCGGGTGGGGATGAACCGCCCGAATACGTGCGCGACCTCGTGGCACTGCAGTGTTCCCCACGCGGGTGGGGATGAACCGCGCAGAGGAGGTGGACAATGGCTGATCGCGTGGTGTTCCCCACGCGGGTGGGGATGAACCGGGTTTGAGGGGGCGTCCTGGGCGAAGGTGACCCGTGTTCCCCACGCGGGTGGGGATGAACCGGATTGCACGGCGGACCCGGTAACCGGCGGCAAGTGTTCCCCACGCGGGTGGGGATGAACCGCCATCGACGCCTATTTTGAGGAGCAGGTCTCAGTGTTCCCCACGCGGGTGGGGATGAACCGAAAGGCAATCATTGAATATCTTGGATTGAAATGTGTTCCCCACGCGGGTGGGGATGAACCGCTCACCGGCACCATGCGTGAGCAGTACGAAGTGTGTTCCCCACGCGGGTGGGGATGAACCGACCCCGTGGCCGACCAGGTGCAGGGATTCCGGGTGTTCCCCACGCGGGTGGGGATGAACCGGCTCGGACGTGGTGGATGGCAAACCCAATGAAGTGTTCCCCACGCGGGTGGGGATGAACCGCCGCTCTCCCGGAGCACCTTCCCCTCGGAACTGTGTTCCCCACGCGGGTGGGGATGAACCGTGCGTCCTCTGGACTGGACGCGAGAAATTGCTGTGTTCCCCACGCGGGTGGGGATGAACCGGCGTCATTCCCTGGCGGAAACCCTGGAAGGGCGTGTTCCCCACGCGGGTGGGGATGAACCGGGGATATCGCATTCGTCCCGGCAGTGCTCCCGGTGTTCCCCACGCGGGTGGGGATGAACCGACCCCGTGGCCGATCAAGTCCAGGGATTCCGGGTGTTCCCCACGCGGGTGGGGATGAACCGCGGCCCGGCGAGCTCCCAGGCCACGTGCCGTAGTGTTCCCCACGCGGGTGGGGATGAACCGTTGCGCCGCTTTTTGCGCCATGCCCTCCAGGCGTGTTCCCCACGCGGGTGGGGATGAACCGAAAAAGCAGCAACTGAGCGATTTGGAGGCGAAGTGTTCCCCACGCGGGTGGGGATGAACCGGGTTGGTTTTGTCCCCGGATTCGTTCCGGGACGTGTTCCCCACGCGGGTGGGGATGAACCGGGTTGGTTTTGTCCCCGGATTCGTTCCGGGACGTGTTCCCCACGCGGGTGGGGATGAACCGAGAGCCGCTGCTGTCCTATCGTATGCGCTGCTGTGTTCCCCACGCGGGTGGGGATGAACCGCATCATATCCGCCCAGCGTCAAAATCGCTTCGGTGTTCCCCACGCGGGTGGGGATGAACCGAGATCGAAAACGCCATTCTCGAGTATCTCCGGGTGTTCCCCACGCGGGTGGGGATGAACCGTGTGAAACATGCACCCAGCACGTCCAGGGGAAAGTGTTCCCCACGCGGGTGGGGATGAACCGAAAATAATCGAGACCGGACCACTTCCGGACCAGTGTTCCCCACGCGGGTGGGGATGAACCGGGACTTGTCACCGAAAAGTACCTGACCGTCGAGTGTTCCCCACGCGGGTGGGGATGAACCGCCCCGGCGCGGACGTCCGAGAAAGGGATAACCGTGTTCCCCACGCGGGTGGGGATGAACCGCACATCGATGACCCTCGCGTCATCACCTACGAGGTGTTCCCCACGCGGGTGGGGATGAACCG

>NC_008554|19|17|3489022-3493873|CRISPRCasFinder
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCCTTCCTGCCATCCACTTGTCAACGTCCTC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCCATTCGCGTTTATCTCCTCATTGAAAGTGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCATATCAACGCAAGGGGGGGAGCAAGTGAGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TACGGCTACGACCGGATTAATGACGCTGACGTC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCCGGAGCTCATCCGGGCCGCATCGGAAGTGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGACTCACACCCCTTTAGCTTGAATGTCTCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTTCCTGTCGGTCCATGGCTATGTCCACTCAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GTCTGGTTCGGTGGGGTGTGGTCTGGTCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGTGGAGGCTGAAGTGGGCGACGACGGTAAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTTCGTTCGGCATATTCGAGTTGCCTTGCGAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CAGTTTAACCAGTTGAGCAAATATTTTCCACG
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGCTATTCCCCGGACCCCGCGAAAATCGAGGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCCGATGAGCACGCAGGTATCAACCAGCGAGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGGACAGGATGAAGAGCAGAACCTTCTGCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCA	GCCAATGTGAACCGCATCTTTTTGATTCTATC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGAACCTCCCAGACACCCCGGCCAGTTTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCGGCCGTCCGGGGCACGGAAAATCTTCCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCCTTGAGAACGTCCCTCGTGGTGGCGGTAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCCCTCAGCCATGGTTTGACGCCGAACACGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCTCCCCGGCCCGGCGCAACGGAACGCCACGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGACAGGATGCCCCATCAGGAAGGGCACCCAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TATGGCTACGACCGTATTAACGACGTGGATGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGAACGCCCCGGCAAGGGGCACAACTAAGAAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGGGCTGTCCACTGTCTCTTCTCCGGGAAAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCGTCATTCCATTGAATCCGAAGCTGCGGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGGTCGGCCAGCCAACAATATCCCCTTCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCTTGGCGATATGGAGGCAAAGATCGCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CAGTGTTATTTCATTGCCTACGGGCAGGCGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGCGAACTACAAAAACCAACAGTAGGAGGATC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAGACCGTGTGCCCTATGACCTGTGGGCGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCGGATTTCATCCGCACCGTTCCGAGATATGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCTTGGCGATATGGAGGCAAAGATCGCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCATCAATTCACGGGGAAAGTCCTTACCGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCACGTCCCAGGGGAACCCGGGGTTGTGGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTCCTGCGCGCAATCAGAGACCAGGCCGAGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCGAGCGATTTGGCCTGGAAGCAACCCCGGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCATCCAAAACATTCCGTTGAGTGGCTTTCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGCCGTTCCGGGGATGAATCAATAATTCCGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GAACAAACAACCCAGATGTGCTGTTATGATGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATTGTTCGCTGCCACCCCAACCGCCACCACAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGCCTTGGTATATATGGTCTGCTGCTTCGGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATTGTTCGCTGCCACCCCAACCGCCACCACAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGCCTTGGTATATATGGTCTGCTGCTTCGGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTGTCCTATCAGCACTACCTGGAGGAGAAGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGAGTAAAATAGATAGCCCTGGTCGGCTTGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCGTCTATCACCAGGGGCGGATTGTCGGGTA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TAATCCGCGATGTGACGACCTGCGGAACAAGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GATGCCGTCGGGGTTCAAATTGGCGTCGCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCCATTACGTCGCTAATAATCATTCTTCTCTT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GACTGTATAGTTCCTCGACTTCAGATCCATCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GACTGTATAGTTCCTCGACTTCAGATCCATCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCATGGCTGGCATCCAGATCTACCAGGAGCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCGAATACGTGCGCGACCTCGTGGCACTGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CGCAGAGGAGGTGGACAATGGCTGATCGCGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTTGAGGGGGCGTCCTGGGCGAAGGTGACCC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GATTGCACGGCGGACCCGGTAACCGGCGGCAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCATCGACGCCTATTTTGAGGAGCAGGTCTCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAGGCAATCATTGAATATCTTGGATTGAAAT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTCACCGGCACCATGCGTGAGCAGTACGAAGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCCCGTGGCCGACCAGGTGCAGGGATTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCTCGGACGTGGTGGATGGCAAACCCAATGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCGCTCTCCCGGAGCACCTTCCCCTCGGAACT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCGTCCTCTGGACTGGACGCGAGAAATTGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCGTCATTCCCTGGCGGAAACCCTGGAAGGGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGGATATCGCATTCGTCCCGGCAGTGCTCCCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCCCGTGGCCGATCAAGTCCAGGGATTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CGGCCCGGCGAGCTCCCAGGCCACGTGCCGTA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGCGCCGCTTTTTGCGCCATGCCCTCCAGGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAAAGCAGCAACTGAGCGATTTGGAGGCGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTGGTTTTGTCCCCGGATTCGTTCCGGGAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTGGTTTTGTCCCCGGATTCGTTCCGGGAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGAGCCGCTGCTGTCCTATCGTATGCGCTGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CATCATATCCGCCCAGCGTCAAAATCGCTTCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGATCGAAAACGCCATTCTCGAGTATCTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGTGAAACATGCACCCAGCACGTCCAGGGGAAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAATAATCGAGACCGGACCACTTCCGGACCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGACTTGTCACCGAAAAGTACCTGACCGTCGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCCGGCGCGGACGTCCGAGAAAGGGATAACC
GTGTTCCCCACGCGGGTGGGGATGAACCG	CACATCGATGACCCTCGCGTCATCACCTACGAG
GTGTTCCCCACGCGGGTGGGGATGAACCG

>NC_008554|19|3|3489022-3493873|CRT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCCTTCCTGCCATCCACTTGTCAACGTCCTC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCCATTCGCGTTTATCTCCTCATTGAAAGTGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCATATCAACGCAAGGGGGGGAGCAAGTGAGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TACGGCTACGACCGGATTAATGACGCTGACGTC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCCGGAGCTCATCCGGGCCGCATCGGAAGTGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGACTCACACCCCTTTAGCTTGAATGTCTCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTTCCTGTCGGTCCATGGCTATGTCCACTCAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GTCTGGTTCGGTGGGGTGTGGTCTGGTCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGTGGAGGCTGAAGTGGGCGACGACGGTAAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTTCGTTCGGCATATTCGAGTTGCCTTGCGAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CAGTTTAACCAGTTGAGCAAATATTTTCCACG
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGCTATTCCCCGGACCCCGCGAAAATCGAGGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCCGATGAGCACGCAGGTATCAACCAGCGAGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGGACAGGATGAAGAGCAGAACCTTCTGCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCA	GCCAATGTGAACCGCATCTTTTTGATTCTATC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGAACCTCCCAGACACCCCGGCCAGTTTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCGGCCGTCCGGGGCACGGAAAATCTTCCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCCTTGAGAACGTCCCTCGTGGTGGCGGTAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCCCTCAGCCATGGTTTGACGCCGAACACGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCTCCCCGGCCCGGCGCAACGGAACGCCACGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGACAGGATGCCCCATCAGGAAGGGCACCCAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TATGGCTACGACCGTATTAACGACGTGGATGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGAACGCCCCGGCAAGGGGCACAACTAAGAAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGGGCTGTCCACTGTCTCTTCTCCGGGAAAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCGTCATTCCATTGAATCCGAAGCTGCGGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGGTCGGCCAGCCAACAATATCCCCTTCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCTTGGCGATATGGAGGCAAAGATCGCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CAGTGTTATTTCATTGCCTACGGGCAGGCGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGCGAACTACAAAAACCAACAGTAGGAGGATC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAGACCGTGTGCCCTATGACCTGTGGGCGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCGGATTTCATCCGCACCGTTCCGAGATATGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCTTGGCGATATGGAGGCAAAGATCGCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCATCAATTCACGGGGAAAGTCCTTACCGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCACGTCCCAGGGGAACCCGGGGTTGTGGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTCCTGCGCGCAATCAGAGACCAGGCCGAGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCGAGCGATTTGGCCTGGAAGCAACCCCGGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCATCCAAAACATTCCGTTGAGTGGCTTTCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGCCGTTCCGGGGATGAATCAATAATTCCGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GAACAAACAACCCAGATGTGCTGTTATGATGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATTGTTCGCTGCCACCCCAACCGCCACCACAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGCCTTGGTATATATGGTCTGCTGCTTCGGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATTGTTCGCTGCCACCCCAACCGCCACCACAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGCCTTGGTATATATGGTCTGCTGCTTCGGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTGTCCTATCAGCACTACCTGGAGGAGAAGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGAGTAAAATAGATAGCCCTGGTCGGCTTGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCGTCTATCACCAGGGGCGGATTGTCGGGTA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TAATCCGCGATGTGACGACCTGCGGAACAAGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GATGCCGTCGGGGTTCAAATTGGCGTCGCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCCATTACGTCGCTAATAATCATTCTTCTCTT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GACTGTATAGTTCCTCGACTTCAGATCCATCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GACTGTATAGTTCCTCGACTTCAGATCCATCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCATGGCTGGCATCCAGATCTACCAGGAGCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCGAATACGTGCGCGACCTCGTGGCACTGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CGCAGAGGAGGTGGACAATGGCTGATCGCGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTTGAGGGGGCGTCCTGGGCGAAGGTGACCC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GATTGCACGGCGGACCCGGTAACCGGCGGCAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCATCGACGCCTATTTTGAGGAGCAGGTCTCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAGGCAATCATTGAATATCTTGGATTGAAAT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTCACCGGCACCATGCGTGAGCAGTACGAAGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCCCGTGGCCGACCAGGTGCAGGGATTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCTCGGACGTGGTGGATGGCAAACCCAATGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCGCTCTCCCGGAGCACCTTCCCCTCGGAACT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCGTCCTCTGGACTGGACGCGAGAAATTGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCGTCATTCCCTGGCGGAAACCCTGGAAGGGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGGATATCGCATTCGTCCCGGCAGTGCTCCCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCCCGTGGCCGATCAAGTCCAGGGATTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CGGCCCGGCGAGCTCCCAGGCCACGTGCCGTA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGCGCCGCTTTTTGCGCCATGCCCTCCAGGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAAAGCAGCAACTGAGCGATTTGGAGGCGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTGGTTTTGTCCCCGGATTCGTTCCGGGAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTGGTTTTGTCCCCGGATTCGTTCCGGGAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGAGCCGCTGCTGTCCTATCGTATGCGCTGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CATCATATCCGCCCAGCGTCAAAATCGCTTCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGATCGAAAACGCCATTCTCGAGTATCTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGTGAAACATGCACCCAGCACGTCCAGGGGAAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAATAATCGAGACCGGACCACTTCCGGACCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGACTTGTCACCGAAAAGTACCTGACCGTCGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCCGGCGCGGACGTCCGAGAAAGGGATAACC
GTGTTCCCCACGCGGGTGGGGATGAACCG	CACATCGATGACCCTCGCGTCATCACCTACGAG
GTGTTCCCCACGCGGGTGGGGATGAACCG

>NC_008554|19|4|3489816-3493873|PILER-CR
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGGACAGGATGAAGAGCAGAACCTTCTGCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCA	GCCAATGTGAACCGCATCTTTTTGATTCTATC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGAACCTCCCAGACACCCCGGCCAGTTTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCGGCCGTCCGGGGCACGGAAAATCTTCCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCCTTGAGAACGTCCCTCGTGGTGGCGGTAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCCCTCAGCCATGGTTTGACGCCGAACACGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCTCCCCGGCCCGGCGCAACGGAACGCCACGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGACAGGATGCCCCATCAGGAAGGGCACCCAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TATGGCTACGACCGTATTAACGACGTGGATGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGAACGCCCCGGCAAGGGGCACAACTAAGAAG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGGGCTGTCCACTGTCTCTTCTCCGGGAAAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCGTCATTCCATTGAATCCGAAGCTGCGGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGGTCGGCCAGCCAACAATATCCCCTTCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCTTGGCGATATGGAGGCAAAGATCGCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CAGTGTTATTTCATTGCCTACGGGCAGGCGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGCGAACTACAAAAACCAACAGTAGGAGGATC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAGACCGTGTGCCCTATGACCTGTGGGCGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCGGATTTCATCCGCACCGTTCCGAGATATGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCTTGGCGATATGGAGGCAAAGATCGCCGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATCATCAATTCACGGGGAAAGTCCTTACCGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCACGTCCCAGGGGAACCCGGGGTTGTGGGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTCCTGCGCGCAATCAGAGACCAGGCCGAGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCGAGCGATTTGGCCTGGAAGCAACCCCGGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTCATCCAAAACATTCCGTTGAGTGGCTTTCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGCCGTTCCGGGGATGAATCAATAATTCCGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GAACAAACAACCCAGATGTGCTGTTATGATGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATTGTTCGCTGCCACCCCAACCGCCACCACAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGCCTTGGTATATATGGTCTGCTGCTTCGGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ATTGTTCGCTGCCACCCCAACCGCCACCACAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGCCTTGGTATATATGGTCTGCTGCTTCGGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTGTCCTATCAGCACTACCTGGAGGAGAAGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACGAGTAAAATAGATAGCCCTGGTCGGCTTGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCGTCTATCACCAGGGGCGGATTGTCGGGTA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TAATCCGCGATGTGACGACCTGCGGAACAAGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GATGCCGTCGGGGTTCAAATTGGCGTCGCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCCATTACGTCGCTAATAATCATTCTTCTCTT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GACTGTATAGTTCCTCGACTTCAGATCCATCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GACTGTATAGTTCCTCGACTTCAGATCCATCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TCATGGCTGGCATCCAGATCTACCAGGAGCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCGAATACGTGCGCGACCTCGTGGCACTGCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CGCAGAGGAGGTGGACAATGGCTGATCGCGTG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTTGAGGGGGCGTCCTGGGCGAAGGTGACCC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GATTGCACGGCGGACCCGGTAACCGGCGGCAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCATCGACGCCTATTTTGAGGAGCAGGTCTCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAGGCAATCATTGAATATCTTGGATTGAAAT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CTCACCGGCACCATGCGTGAGCAGTACGAAGT
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCCCGTGGCCGACCAGGTGCAGGGATTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCTCGGACGTGGTGGATGGCAAACCCAATGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCGCTCTCCCGGAGCACCTTCCCCTCGGAACT
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGCGTCCTCTGGACTGGACGCGAGAAATTGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	GCGTCATTCCCTGGCGGAAACCCTGGAAGGGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGGATATCGCATTCGTCCCGGCAGTGCTCCCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	ACCCCGTGGCCGATCAAGTCCAGGGATTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	CGGCCCGGCGAGCTCCCAGGCCACGTGCCGTA
GTGTTCCCCACGCGGGTGGGGATGAACCG	TTGCGCCGCTTTTTGCGCCATGCCCTCCAGGC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAAAGCAGCAACTGAGCGATTTGGAGGCGAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTGGTTTTGTCCCCGGATTCGTTCCGGGAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGTTGGTTTTGTCCCCGGATTCGTTCCGGGAC
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGAGCCGCTGCTGTCCTATCGTATGCGCTGCT
GTGTTCCCCACGCGGGTGGGGATGAACCG	CATCATATCCGCCCAGCGTCAAAATCGCTTCG
GTGTTCCCCACGCGGGTGGGGATGAACCG	AGATCGAAAACGCCATTCTCGAGTATCTCCGG
GTGTTCCCCACGCGGGTGGGGATGAACCG	TGTGAAACATGCACCCAGCACGTCCAGGGGAAA
GTGTTCCCCACGCGGGTGGGGATGAACCG	AAAATAATCGAGACCGGACCACTTCCGGACCA
GTGTTCCCCACGCGGGTGGGGATGAACCG	GGACTTGTCACCGAAAAGTACCTGACCGTCGA
GTGTTCCCCACGCGGGTGGGGATGAACCG	CCCCGGCGCGGACGTCCGAGAAAGGGATAACC
GTGTTCCCCACGCGGGTGGGGATGAACCG	CACATCGATGACCCTCGCGTCATCACCTACGAG
GTGTTCCCCACGCGGGTGGGGATGAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011699668.1\|3479428_3480433_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_008554.1\|WP_041440652.1\|3497651_3497873_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011699674.1\|3487097_3487706_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|187858
NC_008554.1\|WP_011699677.1\|3496792_3497557_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|100107
NC_008554.1\|WP_011699671.1\|3484753_3485233_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl\|CDD\|187862
NC_008554.1\|WP_011697013.1\|3494179_3494959_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NC_008554.1\|WP_041439521.1\|3494955_3496206_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NC_008554.1\|WP_011699670.1\|3483196_3484750_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl\|CDD\|187860
NC_008554.1\|WP_011699679.1\|3498195_3498636_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NC_008554.1\|WP_011699666.1\|3474240_3475392_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|273178
NC_008554.1\|WP_167321354.1\|3498947_3500981_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|379930
NC_008554.1\|WP_011699676.1\|3488609_3488972_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	pfam09707_cas2_CAS-I-E	gnl\|CDD\|236930
NC_008554.1\|WP_011699683.1\|3503883_3504435_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011699675.1\|3487708_3488629_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_008554.1\|WP_011699672.1\|3485267_3486422_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_008554.1\|WP_011699667.1\|3475391_3478454_+\|SMC-family-ATPase	unknown	unknown	gnl\|CDD\|223496
NC_008554.1\|WP_011699682.1\|3501918_3503181_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369518
NC_008554.1\|WP_011699681.1\|3501222_3501519_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011699684.1\|3504448_3504823_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011699669.1\|3480614_3483179_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011699668.1\|3479428_3480433_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.26872e-44
NC_008554.1\|WP_167321354.1\|3498947_3500981_+\|PAS-domain-S-box-protein	gnl\|CDD\|379930	pfam17159, MASE3, Membrane-associated sensor domain. MASE3 (Membrane-Associated SEnsor) is an integral membrane sensor domain of unknown specificity found in histidine kinases, diguanylate cyclases and protein phosphatases in various bacteria and archaea.	1.82482e-111
NC_008554.1\|WP_011699674.1\|3487097_3487706_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|187858	cd09727, Cas6_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas6e. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6e is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-E subtype; Homologous to Cas6 (RAMP superfamily protein); Possesses double RRM/ferredoxin fold; also known as Cse3 family.	2.40538e-63
NC_008554.1\|WP_011699677.1\|3496792_3497557_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|100107	cd02440, AdoMet_MTases, S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).	9.78005e-10
NC_008554.1\|WP_011699671.1\|3484753_3485233_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|187862	cd09731, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	4.14634e-34
NC_008554.1\|WP_011697013.1\|3494179_3494959_-\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	7.26787e-95
NC_008554.1\|WP_041439521.1\|3494955_3496206_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.37847e-42
NC_008554.1\|WP_011699670.1\|3483196_3484750_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	3.40019e-121
NC_008554.1\|WP_011699679.1\|3498195_3498636_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	6.4602e-32
NC_008554.1\|WP_011699666.1\|3474240_3475392_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|273178	TIGR00619, Nuclease_SbcCD_subunit_D, exonuclease SbcD. All proteins in this family for which functions are known are double-stranded DNA exonuclease (as part of a complex with SbcC homologs). This complex functions in the initiation of recombination and recombinational repair and is particularly important in regulating the stability of DNA sections that can form secondary structures. This family is likely homologous to the MRE11 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.78615e-51
NC_008554.1\|WP_011699676.1\|3488609_3488972_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	5.4419e-63
NC_008554.1\|WP_011699675.1\|3487708_3488629_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	1.56135e-149
NC_008554.1\|WP_011699672.1\|3485267_3486422_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	3.78385e-131
NC_008554.1\|WP_011699667.1\|3475391_3478454_+\|SMC-family-ATPase	gnl\|CDD\|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	3.04781e-76
NC_008554.1\|WP_011699682.1\|3501918_3503181_+\|hypothetical-protein	gnl\|CDD\|369518	pfam07787, TMEM43, Transmembrane protein 43. This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.	7.63704e-101
NC_008554.1\|WP_011699669.1\|3480614_3483179_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	5.2833e-115

>NC_008554.1|WP_011699676.1|3488609_3488972_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MLVIVVENAPARLRGRLAVWLLEIRAGVYVGDYSRRVREMIWKQVELGITEGNAVMAWSTNSESGFDFLTFGQNRRVPCELEGIKLVSFLPSNETEEQKCAISATNRELSEGHPNGNDSW
>NC_008554.1|WP_011699675.1|3487708_3488629_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MQSQLPPLRPIPIKARVSVLFLEKGNLDVLDGAFVVVDKNGVRTHIPVGGVACLMLEPGTRVSHAAAVLASRVGCLLIWVGEAGVRLYASGQPGGARADRLLYQARLALDDTARLKVVRKMYAVRFGEEPPAHRSIEQLRAIEGSRVKNLYKLFAKQYGVPWHGRKYDPDEWGSGDTANRCLSAATACLYGVAEAAVLAAGYAPAVGFIHTGKPLSFVYDIADIFKFETVVPVAFKVAAQRSGEPERAVRIACRDAFRKSQLLTRIIPTIETILNAGGLNRPDPPEDSVPPAIPNKEQSGDAGHRG
>NC_008554.1|WP_011699674.1|3487097_3487706_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSLLSLDRLHRGTMRLLSDIYLLHKGIMSGFTRCGDGLRVLFRVEPENDDRIVRIMVQSDGSPSWELFTERHPCVIDMRTKVFSPALRAGHSYRFRLRANPAVKRNGKRYGLIRDETLEEWLRRKEPALGLQFRSVLALDEGYVTGHKEGSGHPQRINIKTARFEGILTVSEPHLVQNALCCGIGPAKAFGCGLLSLARV
>NC_008554.1|WP_011699672.1|3485267_3486422_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MFVDIHIIQNFAPSNLNRDDTNSPKDCEFGGYRRARISSQCIKRVVRSHRSFSQAVVHAGGDTGVRTKRIKSRLMDLFAKKYGKPEIVETEKVAETVIELLGLKLKDEEKTEYLLYLGENEAAQLARLAVDSWDALLAIEPEQDKKKKKGTGQESLKEFQEELKGIVGKRRKEARSYAADIALFGRMIADNKNMNVDAACQVAHAVSTNKVEMEMDYFTAVDDLLPGEETGSDMIGVVEFNSSCFYRYSNVNVSKLAENLGFNNDLTTAALLGYVEASVKSVPTGKQNSMAAQNPAGYARVIVRRDGFPWSLANAFQKPVRPSLDKSLEEASIDALERYFERLKAVYGTEGIVCDASFNLHRDDGGSLRKMLDALKACVAGEGS
>NC_008554.1|WP_011699671.1|3484753_3485233_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MKSGENPFVAYLERLRDENDRAALAKLRRGLGKKMGTPEMYPFVVPFMPDDRRVREHYFLVASLFASHPDPAPIERSMGGVFKAILGKTESDSIEKRFVQLLSADIEDVGKYLRHAISLARSKGVAVNYHRLLSDLRYWEHRDRFVQLQWARDFWGFQK
>NC_008554.1|WP_011699670.1|3483196_3484750_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MSAFSFNLIDRPWISCVELSGRRRTLGLHEVLSRAHELRGIELQSPLAETALFRVLLAAVHRIVEGPKGTGEWRALYQATKLPGGRIDAYFEKWSHRFDLFSKEEPFYQTPGLAIRDAKGAEAPAVIAGIMLERASGNNKTIFDHSMDEDRGCLSPEEAVLALIAAQMYSLRGLNKKTTNLFGYQESFSDSVMVGGIFAALQGQSLFESLLLNLLLYTDNLPIHSSRDDCPVWERHDHGETGVRTPRGYLDYLTCKCRHILLVPEPGLDGPCIRHVHIAQGEAFQDVDNPGFIKRKNKEGKWLPVQMQPARLVWRDSISLFSFDTGKREGDRRPDAFRLVGDIALRRIVALPSKYRCCTYGLANDQANPLAWRKETLNIPTALLSDPDLVACLREAMDLSEKAHTILRNAIRTYMDKYLPRNSRDVTEKLNATGASRLFWDRLESHFNAFLLEIENQDKALVAWERNIERAALEAFEACLKQRYADSAKKFRAWTEAHGQLVARLATLSKTLSRKGG
>NC_008554.1|WP_011699669.1|3480614_3483179_+|CRISPR-associated-helicase/endonuclease-Cas3
MTEEDVFRFWGKTSGNVVHPAVCHMLDTGIVACELLMVQPHGFISKLADEFGITTDALPQLAAFLAALHDIGKISPGFQAKRPDLSAPLKLEGYVFSRADEDRHTLSTLETLPDLLIDCLQCEDSLAIALSRALAAHHGVFTGQEAQKVGAGKWIKARRAALEFLSRLFWDKSLTGLGFPSTPALVILAGLVSVSDWLSSAEENFPYLTCPRPDLREYVADRTQKARELVSRLRFDVSSPAATEFHQLFDFTSPNPSQTVTLQTVNELHHPMLVVIESPMGSGKTEAAQAVYAHLSCEAGLRGMYYALPTQATGNAMLPRTARFLTRLGLETGTELHLLHTNADLNQDYERLRISSLNAEPGDVSASSWFTARKRGLLAAHGVGTLDQALLAALKVRHFFVRLFGLAGKLLVLDEVHAYDAYMVEEIYRLIGWLAHCHTSVVLLSATLPKARRKKLIQAFRPEVEVPDDIRYPCVTGVDISGAFAAHPIEGLKPDTIYVEPVIAESTDKPARILSLLLEKLADGGCAACIMNTVGEAQDLHELLRHHFPADEVLLFHSRFTLERKLRIEHDILSRYASDGKRPHRGIVIATQVIEQSLDVDFDLMITDLAPIDLLLQRAGRLHRHERARPQLLRPRNLWVLMPEFRSRLPDFGGSEYVYTPDILLKTALLFSAEEDLSHLEVSIPTGVSALIECVYGDDFPPEVPEHLLGPMRGWEAKRLGDETSQTFFAACSALIEAKACLRDPDYLGQISMDNDDDCAIVTRLTRPNVMLVVVENGRCLTVADKAEERKLFSSTVATDNTAIVKHFLAKEPPGEWADSPLLRHCRPLFVSGGKSVERPDLSYDDEFGLRFAR
>NC_008554.1|WP_011699668.1|3479428_3480433_+|WYL-domain-containing-protein
MKARFTQTRHRNLEETKRISRILELTRMILVNPRRYLRRDLSSRFEVSERMIQKDLEIIRHGLRLLLAHSPEGYYFEETPSLPPVRYSFSEALALLLAVQAARRLAGISSSDLAAAIARLESLFPAEFAPHLRAAAGAPGMRTGREHRQEMLRLLNLALIEGRKVRIVYETASRGGERNERVVCPYHLLSYVRSWHLIARCELREAVLVFKVDRISEAELLEHRYSIPRDFSVDDYLGMSWGMMRGGAQAPVDVALRFTPEAGRWVSEEHWHKSQRVEVEPDGHVLFRLHLPVTPEFVNWVLYYGSRVEVVTPESLREIVAEEHQRAAGLYGQS
>NC_008554.1|WP_011699667.1|3475391_3478454_+|SMC-family-ATPase
MRPLKLTLSAFGPYASEQVFDFRVLGDRSFFLIHGPTGSGKSTLLDAVCFALYGETSGGERDVRHLRSDYARASTPTRVTFDFSLGEAVYRITRSPEQERPRARGEGTVVQRPAAVLHDRTGLVDESREGALLAGQWTRVTDRMEQLLGFKSSQFRQVVMLPQGQFRKFLTADSRERQAILEVLFQTEIYRRIEEAVKEAAREIQHALEDLGKRRRLILEQAAVESERQLAEAMEGFAARLEALGGQVEALKKSEALANEAVNKGREIRRILDEAARAQAEFAALEKRKPEIEDRRVKLDRARKAAGLRGVEANLAAREKEFGDASVRVRTAEIEIEKARAARQAAEAALAGEREREGEREAARRDVVQLTAMIDQVRELEAARSDLGGMKARVERVERLRGLRAAALERCRIEMAEAGAALEETEAQAVHAERYRLEVRQAAASYRATIRLKTSEKHLALALAHRKKTEAAAGTALAVLTDARTALDGMEREWLEGQAAILAGRLADGLPCPVCGATDHPSPARHGGELPTEAAHKKARTHARELESRYEKARLESERANLEVAALQSAAANLRAEAGEVPAEGFRDLKTRLRDAWARFRTAVAARAQVTDRAVALKAVEERTAGNEKRLRRLENGLRAAVRRMDGQAAVMAEREGKVPDRLRDLKALERAISTAQKRLRSLLDAQEAARARQEAAAARAAACEETLRNAVEALESAKERAGSCREELRLRLAEEGFSSVEDYRAAKLDRKDVDRMEREIADFHGRHRAARERLDRAVAAAQGLETPVLEELERKAREASEALRSAIARHGALRAQSDQLARWNADLHKLAGEMEAAQNRYGIVGRISEVANGKNAPGLTFQRFVLAALLDDVLDAASRRLRRMSRGRFDLQRSRERGDQRAAAGLDLAVYDTYTGTTRPVNTLSGGESFLSSLAMALGLADVVRAYAGGIRLETIFVDEGFGSLDQESLDLAFQTLVDLQEGNRLVGIISHVPELRERVDARLEVIPGIRGSDARFVL
>NC_008554.1|WP_011699666.1|3474240_3475392_+|exonuclease-SbcCD-subunit-D
MRILHTADWHLGRIFHGVHLTADQAFVLDRLVRLASESKPDVVLVSGDVYDRAVPPPDAVALLDDTLSRLVLGLRIPVILIAGNHDSPERLSFGSKVLAAQCLHLAGTPAPDATPVVIDDRHGPVSFCSLPYAEPALVRERLDRKDVVDHDSAMAAQIESARRRLPAGSRAVLVAHAFVAGGIESESERSLSVGGAAAVGVEHFEGFHYAALGHLHRPQRAGADHVQYAGSLLCYSFAEAGQTKSVNLVELDAAGRCAVERIPLAPSHEVRCIRGAFRELLAGPRAAESREDYIMAVLTDKEPILDAHGRLSEIYPNLLHIERSHLAAAGETGGAARDHRRLSDLELFRAFFSQVTGDELTPEQAEAYAEIVENLRRAEREAD
>NC_008554.1|WP_011697013.1|3494179_3494959_-|ATP-binding-protein
MSSTQLVRIQERLKHLKLYRINEQLESRLEEASRGNVSYGDFLDQLLDEEVSAKKEKNISMRTSMARFPFVKTLESFDFAFQPSIDKKRINELAACRFIANGENVILLGPPGVGKTHLAVALGIKAVTEGYRTHFTQAMPLVASLTKAYAENRIEERLKFYCQPKLLIIDEIGYIPIDRHGAHLFFQLISRRYERGALIVTSNRSFGQWNEIFGDTVIATAILDRILHHSTTVNIKGNSYRLKEKVKAGLLQSPELEQT
>NC_008554.1|WP_041439521.1|3494955_3496206_-|IS21-family-transposase
MVKRELWYEVQSRFKLKESKKSIARSLELSVQTVRSVLKQKAAPSYRRGPGKRTLLSPFEDHIHRRLAALGYCSRAIYEELVEQGYTGCYDTVRRFVQPLRKEAQTKATMRFETPPGRQAQVDWGQCWTLISGKRIKVHLFVMTLGYSRRLFAKATWDERLATFLACHEEAFEHFGGAAHELVYDNAKTVVVSRDVEGRNVKWNATFWDFSTYYGFRAWAHRPYRAQTKGKVESGVRYVKRFVRGKAFESMAHLNTLLGRWLATVADLRIHGTTHQRPIDLFEQERTLLLPTGAKPPYQVRERAVRYVARDCMVSFETNRYSVPLRFVGKPVEVQCANDRILIFHEGSLIVSHPCCTGKHQSLVDREHYTGIFYGIELPSVRMLAFDHALPLCSREEVEVRDLAFYERLAQEGGAS
>NC_008554.1|WP_011699677.1|3496792_3497557_-|class-I-SAM-dependent-methyltransferase
MDMWKFFNITHREHIICNPMNLEKLEQLIALLPLKPGARVLDIATGKGEFLIRLAERYRQMTGTGVDLSPHCIADACTKHQERVPDARLQFLELDGAKYVPETMESFDLIACIGASWIYGGHRGTLNALRKMAAPESWIVVGEPYWRHEPEGEYLEAIGVARNDFGTHYQNVEVGRECGLEAVYTLVSSQDDWDRYEGLQWYAAETWASDHRDDPDVETVLKRVHESKRAYLRWGREALGWAIYVFRKGGAAHF
>NC_008554.1|WP_041440652.1|3497651_3497873_-|hypothetical-protein
MELARKTGPPDPGYNAAIGNGIVALMDAWRYEDVAARLHELTNPSMRNDLENMMAFGLRCCFLPRPDEVFKKT
>NC_008554.1|WP_011699679.1|3498195_3498636_-|acyl-CoA-thioesterase
MEALLKDFPVVAEIETAWGEMDAMRHLNNVVYFRYFETARVRYAERAGMWDHMEKTGIGPILHSTRCRYKIPLTYPDTVYVGTRVVKMEKDRVVMDYTLVSGRLRKVAATGEAVIVSIDYRSGRKVPLPEEWRRRILEIEGPALPG
>NC_008554.1|WP_167321354.1|3498947_3500981_+|PAS-domain-S-box-protein
MEGQFVRQRRLAAVVASLLILAALFVVSRFNYLLFHSLAEMFSVVIACSIFVVAWNSRHFLNNGYLLLIGIAYLFVGTLDTLHMLSYKGMGVFPGDSADTPTQLWIASRYMESIALLVAPTLMTRRIDAGRVFGWFLAATGILLFAIFPANVFPVCYVEGVGLTPFKKASEYIICLTLAAAIVLLLRQRRFFDPGVLRLLVGSIAAAIVCELAFTFYVGVYDLSNLTGHFFKIISFTLTYKAIVETGLVKPYNLLFRDLKLGEAALRAANDQLENKVRARTAELSEANEALASEVVERKQAEAALRRSELKYRELVEHANSIILRLDAQGKILFFNEFAQNFFGFREGEILGRQAVGTIVPETETSGRDLASMMRRMLSDPEVYSSNEYENMRRNGERVWVAWTNKAIRDGNGRIAEILCIGNDISARRRIEEELERSNRELQEFAFIASHDLKEPLRKVMAFGDRLHSRFGERLDEDGRDYLARMRKAAFRMQNLIESLLNYSRVTTKAETFSTVDLNVLIKEILSDLETSIAENGVRIEVERLPIIQADSNQMRQLFQNLISNALKYHGTEAPFVGIRGKKAAPTPGGTGSGGPSWYQVLVEDNGIGFDEKYLDRIFAPFQRLHGRDAYEGTGMGLAICRKIMERHGGTLTANSTPGRGSTFIVTLPARSVRSAP
>NC_008554.1|WP_011699681.1|3501222_3501519_+|hypothetical-protein
MKAAMIFTGSGPILVLTTFESLEDAGFIERLNARGIAKFIAHEVSVEKVKKQYGTRFSVILGDLSQSDDLRVMDIDGHHVFHSFAFDELGPAVYHPKH
>NC_008554.1|WP_011699682.1|3501918_3503181_+|hypothetical-protein
MADEDSITEVTQGPGGGFSGGDTYTEVTRQSLPSKIGSSFGGLFFGLILVIAGIVLLFWNEGRTVKTHRALEEGAAAVVPAGPETVNAVNQGKLVHMTGQADADATLADPEFGISARALRLKRSVEMYQWKEDEKSESQKNSDGSTTKRTTYSYRKVWSSSRIDSSRFKKQENHSNPAAMPYREKVFDARTRFGAFTLPPTLVAKIPGEEDLPVPDSPATVPASLQGKARVHEGAWYIGQNLQEPAVGDVKVRFRIKKPGTVSVIAKQWGNTFEPYITKNGREIELVAAGAQSPETMFAHAVDENKTLSWILRGVGFLVVFIGLLLVLNPFVVLLDAFSFLGNIFVLGSLVQGIQGLVAAGIFVVSLVLGLILALVTIAIAWMFYRPLLAVLLIAVAVGLLFGMRFLPRRGKIAQQGAAA
>NC_008554.1|WP_011699683.1|3503883_3504435_+|hypothetical-protein
MDPGFWRSVCYAVVFLGAALVVTGSIGTYYFTARMEAVAPFRQSVKTATAVLEIAVESDAKINTEYLDKGATADFSREGEILLRMSSVSSSARQSGSGRVIYGAKLGMNAADAGLGTPVQALKTADTVRVFFQKMPLESKVLTGRLSVTINGEVLVEIDIPSQEVKDGLVAARGIFGAFSHFQ
>NC_008554.1|WP_011699684.1|3504448_3504823_-|hypothetical-protein
MNSIVFVYVILGLVSAVGLVLVICGLFRTPRKTGPSGELCGPEPFTTIVPVDEPGKIAVPAGEEDDVGTFSHKSLFDPDRHVTEMVRAQDDKEPQLSSPKRPRFDRMKRVLGLSGRKRSSRGLE

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Crispr_ID: NC_008554_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_20

4030450-4030548

Orphan

Consensus_repeat	Method
AATAGGTCCTATAAGACCTATAGGACCTGTCAAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_20

>merge|NC_008554|20|4030450-4030548|CRISPRCasFinder
AATAGGTCCTATAAGACCTATAGGACCTGTCAAGAATCTCTGGAGCTTCTCAGGCAAAGAAGGAAATAGGTCCTATAAGACCTATAGGACCTATCAAGA

>NC_008554|20|18|4030450-4030548|CRISPRCasFinder
AATAGGTCCTATAAGACCTATAGGACCTGTCAAGA	ATCTCTGGAGCTTCTCAGGCAAAGAAGGA
AATAGGTCCTATAAGACCTATAGGACCTATCAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011700091.1\|4034580_4035408_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_008554.1\|WP_041442993.1\|4020539_4021526_-\|NAD(P)H-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176180
NC_008554.1\|WP_041440822.1\|4039637_4040411_-\|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl\|CDD\|223868
NC_008554.1\|WP_041440819.1\|4036992_4037616_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_150109671.1\|4028518_4029787_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|376667
NC_008554.1\|WP_011700082.1\|4022254_4022890_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|377516
NC_008554.1\|WP_011700092.1\|4035599_4036127_+\|chemotaxis-protein-CheD	unknown	unknown	gnl\|CDD\|319352
NC_008554.1\|WP_011700089.1\|4030649_4032317_-\|acyl-CoA-dehydrogenase-domain-containing-protein	unknown	unknown	gnl\|CDD\|173850
NC_008554.1\|WP_011700090.1\|4032855_4034364_+\|response-regulator	unknown	unknown	gnl\|CDD\|225116
NC_008554.1\|WP_011700081.1\|4021537_4022215_-\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NC_008554.1\|WP_011700085.1\|4025178_4027266_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|237973
NC_008554.1\|WP_011700079.1\|4019679_4020468_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_008554.1\|WP_011700083.1\|4023369_4024290_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NC_008554.1\|WP_011700088.1\|4029989_4030379_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_008554.1\|WP_041440812.1\|4027316_4027682_-\|response-regulator	unknown	unknown	gnl\|CDD\|225114
NC_008554.1\|WP_083764206.1\|4038332_4039568_-\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|376389
NC_008554.1\|WP_041440818.1\|4036654_4036927_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|377300
NC_008554.1\|WP_041440816.1\|4036336_4036594_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700084.1\|4024430_4024955_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319875
NC_008554.1\|WP_041442999.1\|4037990_4038308_+\|divalent-cation-tolerance-protein-CutA	unknown	unknown	gnl\|CDD\|376987

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011700091.1\|4034580_4035408_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.86554e-13
NC_008554.1\|WP_041442993.1\|4020539_4021526_-\|NAD(P)H-quinone-oxidoreductase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.1822e-177
NC_008554.1\|WP_041440822.1\|4039637_4040411_-\|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	1.98761e-63
NC_008554.1\|WP_150109671.1\|4028518_4029787_+\|TSUP-family-transporter	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	4.15012e-15
NC_008554.1\|WP_011700082.1\|4022254_4022890_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|377516	pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.	1.14305e-53
NC_008554.1\|WP_011700092.1\|4035599_4036127_+\|chemotaxis-protein-CheD	gnl\|CDD\|319352	cd16352, CheD, chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins. This family contains bacterial chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). The CheD chemotaxis gene is not found in the Escherichia coli genome, but is present in many other organisms, including B. subtilis, where CheD appears to have two separate roles; it binds to chemoreceptors to activate them as part of the CheC/CheD/CheYp adaptation system, and it deamidates selected residues to activate chemoreceptors, enabling them to mediate amino acid chemotaxis. CheD has been shown to catalyze amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptors McpA, McpB and McpC; deamination by CheD is required for the chemoreceptors to effectively transduce signals to the CheA kinase. CheD's ability to bind the receptors is controlled by CheC via a competitive binding mechanism; substituting Gln into the receptor motif of the signal-terminating phosphatase, CheC, turns the inhibitor into a receptor-modifying deamidase CheD substrate. Also, CheYp increases the affinity of CheD for CheC, controlling CheD binding to the receptors through its interactions with CheC. Thus, high levels of CheYp means CheC is a better binding target for CheD than the receptors, resulting in decreased CheA activity. The CheD structure reveals a distant homology with a class of bacterial toxins represented by the cytotoxic necrotizing factor 1 (CNF1) as well as a class of proteins of unknown function represented by B. subtilis YfiH. An invariant Cys-His pair forming a catalytic dyad is observed, and is required by the toxins for deamidation activity.	8.36305e-51
NC_008554.1\|WP_011700089.1\|4030649_4032317_-\|acyl-CoA-dehydrogenase-domain-containing-protein	gnl\|CDD\|173850	cd01161, VLCAD, Very long chain acyl-CoA dehydrogenase. VLCAD is an acyl-CoA dehydrogenase (ACAD), which is found in the mitochondria of eukaryotes and in some bacteria. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. VLCAD acts as a homodimer.	4.67216e-107
NC_008554.1\|WP_011700090.1\|4032855_4034364_+\|response-regulator	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	5.56091e-66
NC_008554.1\|WP_011700081.1\|4021537_4022215_-\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	6.24455e-73
NC_008554.1\|WP_011700085.1\|4025178_4027266_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|237973	PRK15488, PRK15488, thiosulfate reductase PhsA; Provisional.	0
NC_008554.1\|WP_011700079.1\|4019679_4020468_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	8.33341e-91
NC_008554.1\|WP_011700083.1\|4023369_4024290_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	2.95125e-115
NC_008554.1\|WP_011700088.1\|4029989_4030379_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.55404e-11
NC_008554.1\|WP_041440812.1\|4027316_4027682_-\|response-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	3.12033e-24
NC_008554.1\|WP_083764206.1\|4038332_4039568_-\|histidinol-dehydrogenase	gnl\|CDD\|376389	pfam00815, Histidinol_dh, Histidinol dehydrogenase.	0
NC_008554.1\|WP_041440818.1\|4036654_4036927_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|377300	pfam04316, FlgM, Anti-sigma-28 factor, FlgM. FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis. Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28. All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium. The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery.	5.90331e-05
NC_008554.1\|WP_011700084.1\|4024430_4024955_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319875	cd10553, PhsB_like, uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB. This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	4.26334e-83
NC_008554.1\|WP_041442999.1\|4037990_4038308_+\|divalent-cation-tolerance-protein-CutA	gnl\|CDD\|376987	pfam03091, CutA1, CutA1 divalent ion tolerance protein. Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).	1.17717e-45

>NC_008554.1|WP_011700088.1|4029989_4030379_+|sulfite-exporter-TauE/SafE-family-protein
MVVEFWGQEFNVNVILGCIGGFVIAVLSSMFGFGGGPFMVPLMTVGLRLPMFVVVGSSLLAIFFNTVVGSARHFQFGNFDLIFFLVMFPAAILGGYIAPQIAKRVSPLVVKRVAVAGLLLLALNLLGVY
>NC_008554.1|WP_150109671.1|4028518_4029787_+|TSUP-family-transporter
MFYQNNGIAQQAQVNLSQAAPGARPEVAPGGAPAGGLPEAKPEAGTAKAVEPVTIQTDMTALNNGGVLSVTGSAPAGKPVYLEVWAEDAVRASRFDASVDKDTGKRPYILYMTEAMPAYYRIYTPGELKGTLENIKKLKGDWSASQAIKDLGAEAAYSVPARIKIDRYQATLLGSVVGSRGDLLPAMEEKENRRRSMQLVKARFRDPAKVFMPNVEVKPDGTFSAKVNIDGGSAPGKYFIRAVADKDVKSRTITVENNISFPNIYFSNAGTSINFFGPFLLTLAIAIFGVLMGAGGGFILNPLLVSLWPLPHTVVAGTVMPTVAFSQASGIVNYSKIKFINWKLGTTIGLSMVLGAFIGPKLTELVSLSQYKFIFGWILIVLAGLMFWQTMPAYLAKNKKEQAILKEFKKKAEEKTLRPAVA
>NC_008554.1|WP_041440812.1|4027316_4027682_-|response-regulator
MALVLVLDDERDACQLMARIISSFGHEVKAFTDSEEALKWVTRVEPDLALLDVGLRGSYGIDVVDRFLRIRPKLKAILITGYPSMATAGEAFHSGTLDLLVKPVELDELEARVRLALGLIK
>NC_008554.1|WP_011700085.1|4025178_4027266_-|molybdopterin-dependent-oxidoreductase
MTRDVYSLCFMCTIRCPIKVTVENDEVLWIEGNPHVPGIEGALCAKGSAGVALLQDHERLRHPMIRTGPRGSGQWRRASWDEALDFVADRLRGIIERHGAHSILWGERTNLNTHISKAFMKGIGSPNHFTHDALCKGSVNTAFRSLTGYDDTQVGVDYANTKHIVMYGRNLFEALEIKAINNLLSAMGKGAKLTYIDPRVTVTASKATRYWMIRPGTDLALNYALMHVILEEGLFDAEFVRRWVLGLEELRAFVEPFTPARAEEETGIPAAEITALARELAEDKPAVAFHYGYRGAHHTNEVYLRRSIIMLNALMGSIETPGGLFFKKGMKTAGYGELGKYAAQEFPKIAGPRFDGSGSTRFPIADPAHGNPQALAQAILSEQPYPIKALIANRFEPLQSIPDASATREALDKLDLLVSIDINMNEFAWCADVVLPESMYLERGDSIQAVSGLKPQLCIRQQAVTPRHDTKPGWLIVKQLADRLGAGKYLPFETIEDIWNFQLQGTGLTVEELQARGFISLTEKPIFWDRANGLPFKTPSGKIEFVSSLLENAGFPSFPAYARVEPLSEGSFRLLVGRCAVHTHGSTQNNPYLNELVSENELWINSSAAARLGITDGCPVEVSSSRGAATIRAKVTEFIHPEAVFMLHGFGNTVPVQTRACMKGASDALLQENVSDFAGGSPALDETQVRVKRLD
>NC_008554.1|WP_011700084.1|4024430_4024955_-|4Fe-4S-dicluster-domain-containing-protein
MSQYYLHQDQDKCIGCMSCEVHCKVSHGLPVGPRLTQIVEVGPRMVGNLPRTAFVFMPCFHCEVPWCVPVCPTGAMRKRPFDGIVYVEPSLCVGCKRCISACPWGAPQWNPATKKVVKCDYCMDRVDRGLKPACVTKCVTHCLRFGKVTEPNNARRERLARQMAFEPPPSPKQR
>NC_008554.1|WP_011700083.1|4023369_4024290_+|ACP-S-malonyltransferase
MKDWVFLFPGQGSQYVGMGREFYENYSEVRELFSQAGEILEMDIAKLCFEGPEEILVLTDNVQPAVTVVNLACFTVLQLHEIYPMAAAGHSLGEYSALFVAGVLDLKDVLNLVRRRGIFMQEAADEEPGSMAAIMDLDQGKLKEICDTCGVEVANVNCAEQTIITGHVDPVERAISLSTEAGAKMCVKLNVSGPWHSRCMTSARNRFEPHVRRCTFHDPQIPVINNVDAAPLQSAQEAPGKLIDQICSPVLWQQSMESLIAAGHDHFVEVGPKKVLRGLMRRINRNVKALNVEDSASLAAFLQANR
>NC_008554.1|WP_011700082.1|4022254_4022890_-|ABC-transporter-substrate-binding-protein
MLLKAIKGILWTGLLLWLFSLTIPIRAAAAANPPISVIKAGTEQALQILRSSRSGQAPSVRQRRAEIMVIVDRYFNFHEMARRSLGRLWRDQPAEKQAEFVRLFKDMLFNTYIDKVESYTGSNEKFAYDKESIDGDYAVVKTRIQGYKNTDVKVDYRLRFENGEWQVYDVIVEGISLVDNYRSQFASILGNESFDGLLRRMRQKVNEMGRS
>NC_008554.1|WP_011700081.1|4021537_4022215_-|DNA-repair-protein-RadC
MGSGNEGHRARLRERFGRSGLSGFHDHEVLELLLSYAIPRRDVKPLAKDLLSRFGSLAAVLDAPPAVLRNVPGIGPNAAALLSILPELFTRYRESRWHREETFNSTRGAVSYLSALLCTERSEKFCILALNSTNDLIQMEEIQRGSVNRTAVFPRLVVEASLKHRATAVILAHNHPGGDPNPSAADQQLTRRLKRILNDLDIIVHDHIIIAGPRYYSFAEHGGLE
>NC_008554.1|WP_041442993.1|4020539_4021526_-|NAD(P)H-quinone-oxidoreductase
MPAVVVRETGKKGDWNELSIEEVPLPQVKQDEVIVQVHACSVNRADLLQRRGLYPPPLGASSIMGLDFAGTITEVGSNVEGWEPWAKVFGITAGGGYGRYVAVPAAHLVPIPANLSFVDAAAAAEVFFTAFLNIFLEAMIESGETLLIHGGGSGVGTAAIQLARAAAVRVIVTAGSEDKLQRCLELGAAHGINYKEQDFAAEVLELTEGRGVDVILDWIGASYLEKHLRILKTRGRLVLIGLMGGTRTEIQLPVVLTKRLRIIGSVLRSQSDKEKAALVRAFTDWVLPLLESGKVRPVVDRVFPIDKVEEAHQYMLAGEHFGKLVLTW
>NC_008554.1|WP_011700079.1|4019679_4020468_-|ABC-transporter-ATP-binding-protein
MDEWISLNEVSFVRSRRTILDGIDWNISPGDNWVVLGANGSGKTTLLRLLAGYLWPTQGRITVLGERFGQTDLRELRMKIGWVGSFLEAQIPSGQAPLDLIVSGKFASIGIFQTPAEDDYRKARELAKRLGCERIIDLPYGVLSQGEKQRLLIARAMIHRPQLLILDEPCAGLDLVSREQLLRTLQALGEAPDAPCMVLVTHHLQEIMPAFTHVFLLKDGRRLASGTKEEILRSELLSETFGIAVEVVAENGRYWTKVSFTG
>NC_008554.1|WP_011700089.1|4030649_4032317_-|acyl-CoA-dehydrogenase-domain-containing-protein
MPPDAFLERIFHGSIDPDVFQSFRVVQDEAKVDRLRKAYAAILDEYPAGALEAAGAIPERMLRRMGEIGLFGVTIPEEYGGLGFNVWEYMRLVEAMVKMDVSVAIASIAHCSIGVKGVQLFGNDAQKRKYLVPAATGEMIFSYALTEPRIGSDAQHIETLAELSPDGSHYILNGQKTYITNANYAGGLTVFARMDPRRPGFLGVFIVETGWEGVKVGKDMPKMGLKASSTAPVRFTNVRVPVENLLGKPGEGFKIAMTVLNYGRLGLGAASVGMMERSLRDMMKRSSTRVQFQVPIRDFPLIQEKLVRARVNAAVSKAMNDFAAHFLNAAPRLNVAIETSHCKLFGTTRAWDTLYDALQVAGGSGYLSTQPYEKRMRDFRVATVFEGTTEIHSIYPALFLIRKTAKDALRGGRRTAALTFCLKALAARIDWELGFDNRIMRRAWRLAGANARTISRMIPALYLLYRDRLPEKEYLLRRISTLSLYLFGLVALLAGMSARSGSGPYGEEDLRVLAHFTEEAALARKASRRLFDSRKEILDGLICRDLFRGWKDERG
>NC_008554.1|WP_011700090.1|4032855_4034364_+|response-regulator
MRIVIIEDDPHLGKLLDECLHHLGHEKVQLCVSGREARLAMEQETFDCAFIDLKLPDINGLELLEEFKRRDPRLPVVMMSGFPTMHATIEAMQKGASDFLTKPFTMQNVVLALERITKERTLLMENLGLLMECEARKELQLVNLELEEKIREQFKLFEISTEIDEARSSEDLYPCIVRLASGLGSIVKAGFFVLPRGQRSIVRMAEHGPGVNGSSPSIFSIPDDSLRKVFLDDAGHFFLPRHKVEAYSPLPGDFAVEGSALSCWPVRIRGELFGFLAACHNGGNSSLPPTDMKLLDFLVKKSALAIENMALYESLIANFYGILRSLVNALEAKDPYTGKHSERVTRYAISIGRKMGLSGTQVESLNTICHLHDIGKIGIRDNILNKTGALTVEEYELIKQHPVIGETIVAELGLSAEERAIIRYHHERWNGEGYPDGLSRDEIPLLARIVAVADAFDAMTTKRAYREGMSRSEAVLELQRHSGTQFDPAVIDAFLETIRTKA
>NC_008554.1|WP_011700091.1|4034580_4035408_+|HAMP-domain-containing-histidine-kinase
MKYANFPETPEDLDVFYEKCLEALFEKDRLAYLGHFLKGLIHNINGPLQNISMLLEILIRGLDAQDAFMRSHCKTDTEEWDELMLKQRTRFTHLHQQIAGVAQMLRDFMVIYEVERKGTELELNLVLTKLTNVFRADLFFKHQVELDLRLTKNLPMLHIPGRCLIPVLIHLIRNALVAMRGAKRKKLTIESLAMDGKVTVVFKDTGCGSSGNEEMWSGLFYSMWENPMPEGEEEKHSGFGLFAVERLLEPYGGKIRFEREEEGTRVILEIPVNRR
>NC_008554.1|WP_011700092.1|4035599_4036127_+|chemotaxis-protein-CheD
MRNQLAEKEIPELREYFLRPGFIFVSRQPSLISTVLGSCVAVCLRDNLREFGGMNHFLFPLVEDPEQATAKFGNVATNALVRSFLKMGSDPEDLEAQIFGGALLADGLTSAAEVSHANVAIARHVLQRCGVRVVSEDVGGNKGRKLVYNSYTNQVMVIRVERIRSGDWYPYHGSR
>NC_008554.1|WP_041440816.1|4036336_4036594_+|hypothetical-protein
MMITDYLVQSLLRTYGKRLRRRSRDSGKAEVGEDAIARERMAIPDDIRHRMVMERMTSLALEKAYPREEVYMGGERSPDEENPLS
>NC_008554.1|WP_041440818.1|4036654_4036927_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MGTRKNSDHPGRGTRWLEEKANGKARHGKRTASATDDTALITTQVARIVEEIVSGEVRPERIRSIKSLIENDAYTIQPDEIARKMLGELW
>NC_008554.1|WP_041440819.1|4036992_4037616_-|hypothetical-protein
MGEYNQDQWISLQAVRGTCDALAASEVERLKEGCLDYLRFRAGLDRFQDELIAAACRTICFDTGMSACCGFESIFTFFADHVVNTLFSERRETDALFSVLRRANRTGRCVYLGNGGCMWRIRPISCAMFFCDKIKEGILRADPETAERWSALQAMEKEFTWPVKPVLFDDLEKYFLGLGAKSPHMYFHQSPGLLRLKKKSGTGDFRA
>NC_008554.1|WP_041442999.1|4037990_4038308_+|divalent-cation-tolerance-protein-CutA
MAEVSVVLVTAGGEEQASLLAVKLVEEELAACVNIIPRIRSVYRWKNEICDEEEFLLVMKIRSSVFSKLQARVRELHTYEVPEIVRIPIAEGLPDYLDWVRDNSR
>NC_008554.1|WP_083764206.1|4038332_4039568_-|histidinol-dehydrogenase
MGPDVALEKSVIEILLDVKANGDDALLRYTRQFDASELDAERLTVSPEEIRSAYDAVDPELLGIIQEAMANIEAFHRQQLRPSHFITKPDGTFLGQMVRPVEAAGLYIPGGQAGETPLLSSVLMNGIPARLAGVRDIAMVTPPRADGSVSPALLVAAAEVGITRIHRAGSAWGIAALAYGTESVRKVDVVVGPGNIYVSLAKKLVWGAVGIDMLAGPSEILVVADDRGNPRYIAADLLSQAEHDPMASAVLITTEASLAEKVAASLEEQLLRLPRQEIARRALRDYGAIFLAEDLDQALELANGIAPEHLELQVCDPWACLGKIRNAGAVFMGEWTPEAVGDYFAGPNHVLPTAGTARFASALGVENFLKRTSVISFSGNAFRRDAEAIVRMAEMEGLEAHAASIRVRMKP
>NC_008554.1|WP_041440822.1|4039637_4040411_-|septal-ring-lytic-transglycosylase-RlpA-family-protein
MPWRTRVGIGLLLAVLAAGCTRTPPPPPPTPSPPVSGLRTQRPYQINGIWYYPLPSAEGYVEEGTASWYGSDFHGRPTACGERYDMFAMTAAHKTLPLGTYVKVTNLENHRSTILRINDRGPFVAGRIIDLSCRGAQELDSYRKGTARVRVEAVQYASEEKLGTNTYWRVDPVPSFRYGQFTIQIGAFREQPNALKLKDRMSRHFDGAQIVQAYEKGCILHRVQVGMYRDLLLARKELDSLRIHGFSDAFIVAVEGQ

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Crispr_ID: NC_008554_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_008554_21

4622570-4622658

Orphan

Consensus_repeat	Method
AACGAGATCCCGCCCGCGCGAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_008554_21

>merge|NC_008554|21|4622570-4622658|CRISPRCasFinder
AACGAGATCCCGCCCGCGCGAACCGCGGTTAGCTATAAAGCTAGGACTGGCCTAGTTTTACAACCAACGAGATCCCGCCCGCGCGAACC

>NC_008554|21|19|4622570-4622658|CRISPRCasFinder
AACGAGATCCCGCCCGCGCGAACC	GCGGTTAGCTATAAAGCTAGGACTGGCCTAGTTTTACAACC
AACGAGATCCCGCCCGCGCGAACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_008554.1\|WP_011700563.1\|4612888_4613344_+\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NC_008554.1\|WP_011700570.1\|4625764_4626289_-\|DUF2924-domain-containing-protein	unknown	unknown	gnl\|CDD\|371394
NC_008554.1\|WP_011700568.1\|4623766_4624189_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700559.1\|4608329_4609343_+\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|181535
NC_008554.1\|WP_011700573.1\|4627538_4628705_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700561.1\|4610323_4610857_-\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NC_008554.1\|WP_011700564.1\|4613749_4614919_+\|recombination-associated-protein-RdgC	unknown	unknown	gnl\|CDD\|234726
NC_008554.1\|WP_049766436.1\|4609396_4610305_+\|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|236326
NC_008554.1\|WP_011700565.1\|4614940_4615993_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235668
NC_008554.1\|WP_011700577.1\|4631295_4631634_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700571.1\|4626323_4626566_-\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700575.1\|4630084_4630411_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700574.1\|4628697_4629762_+\|hypothetical-protein	unknown	unknown	unknown
NC_008554.1\|WP_011700558.1\|4606427_4607819_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_008554.1\|WP_049766435.1\|4605403_4606015_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|376556
NC_008554.1\|WP_011700567.1\|4618478_4622183_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379224
NC_008554.1\|WP_011700566.1\|4616081_4618295_-\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319845
NC_008554.1\|WP_011700576.1\|4630606_4631191_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_008554.1\|WP_011700569.1\|4624185_4625772_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NC_008554.1\|WP_011700572.1\|4626868_4627492_+\|transcriptional-repressor-LexA	unknown	unknown	gnl\|CDD\|234688

Protein	Function_ID	Function_description	E-value
NC_008554.1\|WP_011700563.1\|4612888_4613344_+\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	1.6626e-37
NC_008554.1\|WP_011700570.1\|4625764_4626289_-\|DUF2924-domain-containing-protein	gnl\|CDD\|371394	pfam11149, DUF2924, Protein of unknown function (DUF2924). This bacterial family of proteins has no known function.	5.97449e-66
NC_008554.1\|WP_011700559.1\|4608329_4609343_+\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|181535	PRK08673, PRK08673, 3-deoxy-7-phosphoheptulonate synthase; Reviewed.	0
NC_008554.1\|WP_011700561.1\|4610323_4610857_-\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	2.9858e-38
NC_008554.1\|WP_011700564.1\|4613749_4614919_+\|recombination-associated-protein-RdgC	gnl\|CDD\|234726	PRK00321, rdgC, recombination associated protein; Reviewed.	0.000149633
NC_008554.1\|WP_049766436.1\|4609396_4610305_+\|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein	gnl\|CDD\|236326	PRK08655, PRK08655, prephenate dehydrogenase; Provisional.	1.22908e-61
NC_008554.1\|WP_011700565.1\|4614940_4615993_+\|hypothetical-protein	gnl\|CDD\|235668	PRK06007, fliF, flagellar basal body M-ring protein FliF.	0.00322619
NC_008554.1\|WP_011700558.1\|4606427_4607819_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_008554.1\|WP_049766435.1\|4605403_4606015_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	7.5138e-28
NC_008554.1\|WP_011700567.1\|4618478_4622183_-\|hypothetical-protein	gnl\|CDD\|379224	pfam13502, AsmA_2, AsmA-like C-terminal region. This family is similar to the C-terminal of the AsmA protein of E. coli.	8.11706e-15
NC_008554.1\|WP_011700566.1\|4616081_4618295_-\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319845	cd07545, P-type_ATPase_Cd-like, P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase. CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_008554.1\|WP_011700576.1\|4630606_4631191_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	2.38318e-10
NC_008554.1\|WP_011700569.1\|4624185_4625772_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	8.47515e-47
NC_008554.1\|WP_011700572.1\|4626868_4627492_+\|transcriptional-repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.21162e-68

>NC_008554.1|WP_011700567.1|4618478_4622183_-|hypothetical-protein
MTRRKKMTLWAGGGAALLLLTLVAAPFIASRVIGLESVREKLLTDVREQTGLHIEFRKLELSFLPTPRLLIHSGGLTLPGKLDGTVDTLVLVPRLLPLFKGELKADIIRLESPKFSITLPQPRVEAQPEPTSFSRRSAEKGVRALISLLKPETHEITIRITNGSFECRDAAGSRFWFREVNARAAMTSERLELSADCMRSNLWESLIVSGWMNPRDLSSSGRVILHGFSPEPLWAYLFPGAAMRFGESRLDLDATLVSEGPRNMRAFFQGSAPIVTLIETDDDQLALKGGAVQGSFALEGRRLEIDLTRLDFLYPQANLTGHFLRDPASSTVSLELEGRDMGASSVREVALALQGERRVVQNIFEIIQEGQVPRITFSTRGKRMGDLRKPENIVIKGNIHHGKVYIPKIKMTVEDVVGDVVITNNVLEGTSLIGRTGNSRGRDGFLRVGLTKDNSTFHLDILIDADLADLPPVLDNTVKSDAFLQELAIMKNVEGKATGKLILGESLRDVNTRVEVGAFELSGDYARIPYRIDLKGESLLFDERMISTSGFSGSFGKTSFSRINLLYRWGEQHYMEITARQQGAKINIDEVHPLLRGVEKNRGIQRPFDVVKGTLSLDALDFKGPILYPKEWIFTGKGSVDDAVVQIPVFPAPYNVKRGRLEGDQETLLLQDCQTRFQDASASVSGSLKGYMENLSSMDLTFQGNVGVDANRSFHDFIDLPATYRNAAPVAVSDAHLVWERTGRTLFEANMVPKGGPRVSMELERIPGQIDIRRLSIKDNDSDAFLSLKIREKGFKLGFYGVLSNKTADRLLIRNELLGGWIRGNFKTYIRLNKPMNSTAWGQLEAAGFVYSHKLGTPARIETARLTANGNKLKVRSARVNWLDARMNVVGSVKFTPSGFKLDMDLSADRVDFEKLKGIWDDTRKAPVPASTPKTSEKRKDLKLRGTLRTGIDNFTFGSLNWSPVQGTVRFLENEVHIDIMRADLCGIPTPGTVNIADGRMQINLKPGGSGLDLDSTLTCLWNRKGLLSGTFDLKGNVSAANVNDDALGLLSGNLELLARKGRMYRFEILAKIFTLINFTEIFRGRLPDLLTEGCSYDTIKAAGKLQDGKLILDNSVVDGSCVRMVWKGEVDLVNRKVNLIVIVAPFRTVDRIIDKVPVVGKLMNGTLISIPVRVTGDLADPTVIPLSPSAVGSGLLGFMKRTFELPFSLLEPFRNQESPETSPSGAPPDTEVK
>NC_008554.1|WP_011700566.1|4616081_4618295_-|heavy-metal-translocating-P-type-ATPase
MERMAFRIRGMCCGDEISVLKRQVGPLVGGELNLSFDLLNGKMTVVSSGPPIRAEEITAVVAATGMQAVPWVDFCSGGVCAVEEGLWRRHGRLLLCCASGLLIVAGFLLHVFQNGSFLEALAGGEHAGRPFPPGTVMLYACAIVAGGWNIAPRAFFAARNLQPDMNLLMAVAVVGAIWIGQWTEAASVTFLFSLALLLESWSVGRARNAIRALTDISPRTARFICPTDGDIEEKPVDDVPVGATVLVRPGEKIPLDGTVTAGASWVDEAPITGESLPVEKRMGDPVFAGTVNGEGAIEFRATRPSGDTTLARIIRMVEEGQARRAPAEQWVERFARFYTPAMMILAGLIAVAPPLVLGGDWTGWFYQALVILVIACPCSLVISTPVSVVSGLTAAARHGVLIKGGAFLEAPAHLRSIAFDKTGTLTRGEPRIQEIIPMDDHTESGLLLNAAALESHSTHPLARAILNAAQARGIEYTPARDFTILPGMGARGVIDGRPYWIGSHRMLESLERESPLFHEMACRLEDAGHSLVAMWCDDHICGVMSVADMVRPEAGEVIRELKSLGVRRVVMITGDNHRTAAQAARAIGVDEFHSELLPEDKVELVSKMEQESGPTAMVGDGVNDAPAMTASSVSIAMGAMGSDAAVETADIALMSDDLTRLPWLVRHSRRTLGIIKSNIAFSLGVKALFVVLSVMGLANLWGAIAADMGASLLVIFNGLRLLGDTVPRSPALTGTAA
>NC_008554.1|WP_011700565.1|4614940_4615993_+|hypothetical-protein
MNEQSSLNFFVDLVSRHWVSVVLLALTVGTILAMVVARWWLRRRLRRMLDEQFEEDHELDALPSPGPADRQALELIREMRREVWSVPDVELELGLDSLNQRAVKIVRAVSAVYHPEAEVPQYEASLIESLQLIRRVTNRINRIAQAPPFRYLGNRKLSDFQRYYQVYRKLNEHPIMRILRRNPHLQRIAGWALNVKNLGNPMYWAGKELSREGYFFLLRWFHLAFTSQVGKEAIRLYSGRRFLTEEDRDATLVCYRLFAVTLQWGGPSSAEWAALVEYIANHTALEAETKLHVLQRCARGKLPRDLDRQRLRTRSGLKWYREGLKRLRGKETEPSPDKLAILQKEDGVLE
>NC_008554.1|WP_011700564.1|4613749_4614919_+|recombination-associated-protein-RdgC
MAISSSSATFTRFFVPDAIREDFWSYVDEKLNEGMFKDPDDGQELAQGFTSWEDFFESSFPYGSYHKGEYLAFNFRIDQRKVPPIVLKKYVREAVRKHRDENEGKWPARHEKIEIQENVRSWLLSRALFQPVACEVVWNTARKWLLVGTTSAKLLDVFLTHFEDMFHMYPVPLYHVHWALNLLPLDGRQKDHLGSMITVQSPLAMDEGRFLGYEFLTWLWFFVEHHGGRIEIPGKVAELHLGERFVLNKPGEGMERVVCTTQANSLHEARTGLRQGKMVHEIQLFLVVGDNEYTFTLDSALWTFKGLKTPRQARDSDQEDQDGEFLEKMFFLEEVFSVLDVLYTRFLSERLGPHWESEHLGLMIKWMEGGKPAGEEGPDTAAEADCAPF
>NC_008554.1|WP_011700563.1|4612888_4613344_+|bifunctional-nuclease-family-protein
MESKDFVEAREVYIKTDRIQGNMVVLKESENDTHYFLMFVGDAEITAIAKEKGLVEPKRPLTHDLYISILNRSGVVIERVEIFAMQENTYYAKIYVRIQGEEAVFDSRPSDAVALALHQKCPIMVSKKLLRRELSPEEIQEYEMIVRTVKF
>NC_008554.1|WP_011700561.1|4610323_4610857_-|metal-dependent-transcriptional-regulator
MLPDDEFHDDLSASLEDYLEVIFHLEQSNRVARAKDIADQMSVQRASVTGALKALAARGLINYSPYSYITLTTAGRDIARDVIHRHDTLKEFFVTALQLSAEEAEANACRIEHAIAPLAVERLVRFLEFINACPRTGKDWFDAFARYCTRGARTSNCEQCLKDCFERNSAPDGKDDD
>NC_008554.1|WP_049766436.1|4609396_4610305_+|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein
MLLSDFIQGESEVKVKLDPGATVGVIGGKGEMGRLFSGFFQSCGFRVNVGDLGTNPTAREVLESSDIVLFSVPLHRTEAIIRDLVPYAKPHQLLLDLSSLKVGPVREMLRSASFVVGLHPMFGGRISTFRGQTIVACPARIPTPDWLRLRSLLSAGGMEVKESTPEEHDRMMSIIQVLFHMTTMLTGRVMRRMGIDLAEVLEYASPGYRVELSQVGRLFAQSPELYSAIIQGNPGTGEVLAQLREGLELYGGWFEKQELSGFVKDFERSARYLGEFCSRAFRDSSVLHETVVKCSEGGSGGD
>NC_008554.1|WP_011700559.1|4608329_4609343_+|3-deoxy-7-phosphoheptulonate-synthase
MIIVLKPDHKESDLHRIVRRLEDLGLGAHISKGEHRTIIGAIGDERVLREVPMESFPGVESVLPILKPYKLVSREFKEENTIVQVNGHQIGGDEIQVIAGPCAVESREVLEEIAGELTAAGVHFLRGGAFKPRTSPYSFQGWGEKGLKLLAGVRERTGMMIVTELMDPRDTVLLCKYADIIQIGTRNMANFRLLTEVGNIDKPVILKRGMSATIKEFLMSAEYIAAQGNEKVILCERGIRTFETETRNTLDISAVPLLKNLTHLPVIVDPSHAVGRADLVPAMARASVAAGADGLLVEVHVRPEEALSDGPQSLRPEAFAVMMEECRRVAVAIGRTM
>NC_008554.1|WP_011700558.1|4606427_4607819_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MKPLFRVLVVDDEPLTLQLVVESLTVEGYDVQIVSSGAEAISASQKNDFDVVITDLAMPGMGGMEVLAHFTEHHPDTFVVVVTGYGTIETAVGAMKRGAFDYLAKPANLDELLFTLKRAQEIRSLKDENVLLRTQIQEQHRFDRIIGQSQLMQSLYHMIRRVAKSHSTVLIMGESGTGKELIANAIHYHSERKDNTFVPINCGAIPEELLESELFGHERGAFTGALRERRGRFELAHGGTILLDEIGEMSPKLQVKLLRFLQEKKFQRLGGSRTIEVDVRILAATNKNLERAVAASEFREDLFYRLNVIPIIVPPLREREGDIPLLVDHFLRQHCQKKELSLKRISKSALDVLERYNWPGNVRELENVIERLVIMTEDGEIEVDDLPQRIRAYQESGIKHLEIGEAGISLKDTLDDLEKRLILEALQKAGGVKNKAAKLLGLNRTTLIEKLKKKGIVCPDGVA
>NC_008554.1|WP_049766435.1|4605403_4606015_-|LysM-peptidoglycan-binding-domain-containing-protein
METIWRISRMYNVSQESIYAANGLRPGEPIAKGQKLTIPNARVMKHVIALYPNSQWKYIIIHHTATDIGNASLIDRTHEDRGFWYGLGYHFLIDNGTLGKGDGQIEASPRWVKQQCGAHCKAGGMNDKGIGIALVGNFNEEQPSSSQLRSLDYLLKTLMDYYRIPAGRVVGHRDVDGAATDCPGRRFPWQTVRRSLSASVLSH
>NC_008554.1|WP_011700568.1|4623766_4624189_-|hypothetical-protein
MKMKPTITVADNGNLQIHIPMLIRRMRGRKTVIAPQALDGEITGAQEPVQSAVLQALGRAFSWADILESGQIKSISELARTLDVDGSYVARILKLTTLAPDIVEALINGEEPNGLSLAKLTQTFPEDWAEQRRQFGFATD
>NC_008554.1|WP_011700569.1|4624185_4625772_-|recombinase-family-protein
MLDNSNVAPGKKKTLRCAIYTRKSHEEGLEQEFNSLDAQRESAEHYIEAQRMRGWTALPDRYDDGGFSGGNMERPGLRRLLADIDAGKIDVIVVYKVDRLSRSLLDFMKMIDLFNEKGVSFVSVTQHFSTTDPTGRMFLGILITFAQYEREVIAERIRDKVAAAKRRGKYCGGVPILGYDVDRDNKKLLVNPDEARTVQYIFRRFIQIGSAKKLGQELNEQGYRTKAWTTKKGKVRDGSEWNTAHIYRLLNNRIYIGEIAHKDRSYPGEHEGIIDRATWDKVQAILEDNKPVKVSMARTKMVAPLKGVIRCGHCGCAMGPTYARKNGRHYTYYICQKDSKRTVSRCPLKRIPAGDIEQAVIEQLSAVFRTPTLVAKTYFAARDIEQAERERLFKQNAQLEIELSQAREQALELMKPGNDQPGKAEMLTTVNRQAVELSKQLTHVSERCRAYQGNSITEQDVSEAFQNVEGFWEDLFPVERNRLIRLLVDKVEIRETGIDMELRTNGLTTLIAELAGLACEVTERRTSR
>NC_008554.1|WP_011700570.1|4625764_4626289_-|DUF2924-domain-containing-protein
MNELQNAATGGKNQDRTRNSVLRQMALLQSMSLEQLREKWLDLYGEEPPQYKKQFLIKRLAYRIQELFYGGLSEQAKVHLQQAAKEDPVATVNRRIPEGRKSNEAILPGTRLVRVWNDRRYEVIVLADGYEFEGRTFRSLSAVAREITGTRWNGKVFFGLKKVYGRKAEGGSDA
>NC_008554.1|WP_011700571.1|4626323_4626566_-|hypothetical-protein
MLDVQEMNDGPGLDDLGENGKPGRLSGEARLQSAASILATAVLRRKAKKACVGNELDVFKDSSPVLGEGLDSLPEQSIHS
>NC_008554.1|WP_011700572.1|4626868_4627492_+|transcriptional-repressor-LexA
MGKAKTDEITPLQRKTLEAICRFVDAKGFPPTVKELSEIFEISPASAHDRINQLVRKGYLKREDGKSRGIAVARRPSEMAASLVSVPVVGMVAAGCPILAEENVTGQVLVESDVVRSGQHFALRAVGDSMVGAGINDGDLIIVRQQPIAEDGDIVVALLNNEATVKRLKIKDELIELVPENPEVRKIRIRPEDDLRVLGKVVGWKRN
>NC_008554.1|WP_011700573.1|4627538_4628705_+|hypothetical-protein
MATFNLRRFSKPEMLRRIDRKHLIAFLEPHAAYFSARGVELPPVQQEDGLDYNALSHLLLTPDSTTPDDLAEALFYVNEVSTPEGFDSIQDEIAGTDIDVEIGENAAPADLAIQVWMADREIIEKVHAEQFFMNVRSFEYFKTKKNPLPDFVLPSEETLAALEADLDEWFSKKRRGKYSKVFVYPKEGHTWFLVRHGKPYAREAVIEAGESTSQYFRPEKFDVLAYNPVIGEIRMNAETKGEKELYRKKFGFHLFGDEEFFNERSRFDLEPLRQIGEDALLCDDVDGIEYVRLKEVQVFWGGAHKDVEIRRSEDIFASLRDRGVSLPGGGKIIKASFQIKFEGSKTPRSVILSSGNRAQFKRDGDAEIIERWLGLRGFIVGAGGVSDE
>NC_008554.1|WP_011700574.1|4628697_4629762_+|hypothetical-protein
MSDPVWAYLERLPGKSAALFDWDKALSGWDRYPLFRDHFLQLTKNHATAVDCPTECGLGCPRSVVTHVKTNIRAICNEKEYPAVQLTTRQTLIYRLKQSAINGAICAALGIEHRESKLDGLPHTWRLGDFIPTAGMDFPVVLTMQDSMDALAEVVRSLCLSIPKPFVLIAPTRLHLSPAVETLLAQRSSPFIALNEELHLGDAPRFMTRRDKAAIFAPLIGQVPEPDSGGTVFFSTPPGTTWAQIKIQFRDGHTVTIWAGDQSGRYTYTQMGMASRKNGNPTEQWKLLEGFANSRGEIDWRSRYASDKLKKQKQELSKHLREFFRLDDDPIEWVKDTKTYRCKFRILPEGAEVY
>NC_008554.1|WP_011700575.1|4630084_4630411_+|hypothetical-protein
MNQTSKAHLTPPKRRLIELMQDINFGRISNIPVRDGEPELTPDTVIEREIKLGGQSGPRPERDQDDFILKQEVVALLEHLAQMGSGKVCLLEIKHGLPFLMRIEERAA
>NC_008554.1|WP_011700576.1|4630606_4631191_+|sigma-70-family-RNA-polymerase-sigma-factor
MVSQNSYDGIDKYAADLIRHKARQLVGKAGFTEDDRPDLEQELMIDLLQRMRHFNPAKAKKTTFMARIVERHISTILEARFAQCRDWRLCQTSLNEPLDNGEGDTTERIDFLDSEGSLGSGTRETRERLAHEIRMDLDRAIASLPEELRDLCVRLHDSTMAEIAREMGIPRTTLYDRLSKLREAFIEAGLTDYL
>NC_008554.1|WP_011700577.1|4631295_4631634_+|hypothetical-protein
MTHDTYKYRFDESVPAQELEDTFMLAMLAVESLHGSSRVRMESRFNLDKARRTCVIDASTDVGSDLARIFTGFATKEYGERSVLIERTQPSGCACASKHRAAPAAAEAGVAV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_008554_8	8.1\|1111799\|44\|NC_008554\|CRISPRCasFinder	1111799-1111842	44	NC_008554.1	2606934-2606977	0	1.0

1. spacer 8.1|1111799|44|NC_008554|CRISPRCasFinder matches to position: 2606934-2606977, mismatch: 0, identity: 1.0

aactgttttcatgcttcgcaggtgaagcacagcctcatggataa	CRISPR spacer
aactgttttcatgcttcgcaggtgaagcacagcctcatggataa	Protospacer
********************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	KM389238	UNVERIFIED: Pseudomonas phage F_HA1208sp/Pa1651 clone contig00002 genomic sequence	7622-7654	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MH719191	Pseudomonas phage Fc22, complete genome	31389-31421	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	NC_006548	Pseudomonas phage B3, complete genome	32208-32240	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MK511059	Pseudomonas phage CF78, partial genome	32807-32839	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	AF232233	Bacteriophage B3, complete genome	32208-32240	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MK511061	Pseudomonas phage CF125, partial genome	32806-32838	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	JX495043	Pseudomonas phage JBD67, partial genome	31267-31299	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MK511057	Pseudomonas phage CF5, partial genome	29439-29471	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	LN898172	Pseudomonas phage vB_PaeS_PM105	32785-32817	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MK511063	Pseudomonas phage CF177, partial genome	32121-32153	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MH719189	Pseudomonas phage Fc02, complete genome	31330-31362	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MK934841	Pseudomonas phage UMP151, complete genome	31868-31900	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	MH719193	Pseudomonas phage H72, complete genome	31791-31823	6	0.818
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	JX495041	Pseudomonas phage JBD18, complete genome	32141-32173	6	0.818
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	NZ_CP012032	Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence	29496-29527	6	0.812
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	NZ_CP043499	Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence	1929403-1929434	6	0.812
NC_008554_19	19.69\|3493201\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493201-3493232	32	NC_016108	Methylomicrobium alcaliphilum 20Z plasmid MEALZ_p, complete sequence	87489-87520	6	0.812
NC_008554_3	3.1\|485117\|33\|NC_008554\|CRISPRCasFinder	485117-485149	33	NZ_CP012918	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p4, complete sequence	71295-71327	7	0.788
NC_008554_19	19.5\|3489296\|32\|NC_008554\|CRISPRCasFinder,CRT	3489296-3489327	32	NZ_CP045122	Rubrobacter sp. SCSIO 52915 plasmid unnamed1, complete sequence	248975-249006	7	0.781
NC_008554_19	19.8\|3489479\|32\|NC_008554\|CRISPRCasFinder,CRT	3489479-3489510	32	MK295205	Shigella phage vB_SflM_004, complete genome	50425-50456	7	0.781
NC_008554_19	19.14\|3489845\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489845-3489876	32	NZ_CP021802	Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence	626857-626888	7	0.781
NC_008554_19	19.34\|3491065\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491065-3491096	32	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1713565-1713596	7	0.781
NC_008554_19	19.34\|3491065\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491065-3491096	32	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1913738-1913769	7	0.781
NC_008554_19	19.41\|3491492\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491492-3491523	32	NZ_CP024792	Nostoc flagelliforme CCNUN1 plasmid pNFSY07, complete sequence	317159-317190	7	0.781
NC_008554_19	19.43\|3491614\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491614-3491645	32	NZ_CP024792	Nostoc flagelliforme CCNUN1 plasmid pNFSY07, complete sequence	317159-317190	7	0.781
NC_008554_19	19.52\|3492163\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492163-3492194	32	MN908690	Microbacterium phage Hubbs, complete genome	20896-20927	7	0.781
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	NZ_CP017949	Tenericutes bacterium MO-XQ plasmid unnamed, complete sequence	78273-78304	7	0.781
NC_008554_19	19.60\|3492652\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492652-3492683	32	NZ_LR594663	Variovorax sp. RA8 plasmid 2	137816-137847	7	0.781
NC_008554_19	19.78\|3493751\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493751-3493782	32	NZ_CP046724	Pantoea agglomerans strain ASB05 plasmid pASB05p2, complete sequence	175634-175665	7	0.781
NC_008554_19	19.78\|3493751\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493751-3493782	32	NZ_CP034471	Pantoea agglomerans strain CFSAN047153 plasmid pCFSAN047153_2, complete sequence	107569-107600	7	0.781
NC_008554_19	19.78\|3493751\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493751-3493782	32	NZ_CP034476	Pantoea agglomerans strain CFSAN047154 plasmid pCFSAN047154_2, complete sequence	88238-88269	7	0.781
NC_008554_20	20.1\|4030485\|29\|NC_008554\|CRISPRCasFinder	4030485-4030513	29	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	73029-73057	7	0.759
NC_008554_18	18.1\|3478615\|31\|NC_008554\|PILER-CR	3478615-3478645	31	NZ_CP018784	Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence	105106-105136	8	0.742
NC_008554_18	18.1\|3478615\|31\|NC_008554\|PILER-CR	3478615-3478645	31	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	738108-738138	8	0.742
NC_008554_18	18.1\|3478615\|31\|NC_008554\|PILER-CR	3478615-3478645	31	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	2103746-2103776	8	0.742
NC_008554_19	19.12\|3489723\|32\|NC_008554\|CRISPRCasFinder,CRT	3489723-3489754	32	NC_009620	Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence	651091-651122	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NZ_CP032755	Lactobacillus plantarum subsp. argentoratensis strain DSM 16365 plasmid unnamed4, complete sequence	25641-25672	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NZ_CP030091	Lactobacillus reuteri strain YSJL-12 plasmid unnamed2, complete sequence	2486-2517	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NZ_CP053340	Lactobacillus paraplantarum strain CK401 plasmid pCK401C, complete sequence	8039-8070	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NZ_CP017376	Lactobacillus plantarum strain TMW 1.708 plasmid pL1708-2, complete sequence	44678-44709	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NZ_CP040905	Enterococcus faecium strain N56454 plasmid unnamed, complete sequence	64266-64297	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NC_022618	Staphylococcus epidermidis plasmid pSWS47, isolate 47, complete sequence	17376-17407	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NC_019371	Lactobacillus plantarum plasmid pG6303, complete sequence	1120-1151	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NC_021517	Lactobacillus plantarum 16 plasmid Lp16E, complete sequence	18225-18256	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NZ_CP028230	Lactobacillus plantarum strain SRCM101222 plasmid unnamed1, complete sequence	17515-17546	8	0.75
NC_008554_19	19.15\|3489906\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3489906-3489937	32	NC_016607	Pediococcus claussenii ATCC BAA-344 plasmid pPECL-4, complete sequence	15401-15432	8	0.75
NC_008554_19	19.19\|3490150\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490150-3490181	32	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1752065-1752096	8	0.75
NC_008554_19	19.19\|3490150\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490150-3490181	32	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1875238-1875269	8	0.75
NC_008554_19	19.20\|3490211\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490211-3490242	32	NZ_CP041045	Paracoccus sp. AK26 plasmid pAK1, complete sequence	308914-308945	8	0.75
NC_008554_19	19.29\|3490760\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490760-3490791	32	HQ634195	Vibrio phage eugene 12A10 genomic sequence	95188-95219	8	0.75
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP024425	Paracoccus yeei strain TT13 plasmid pTT13-3, complete sequence	127631-127662	8	0.75
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	U46938	Mycobacterium phage DS6A, Spe1/NheI G fragment sequence	1401-1432	8	0.75
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	JN698994	Mycobacterium phage DS6A, complete genome	42457-42488	8	0.75
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP024425	Paracoccus yeei strain TT13 plasmid pTT13-3, complete sequence	127631-127662	8	0.75
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	U46938	Mycobacterium phage DS6A, Spe1/NheI G fragment sequence	1401-1432	8	0.75
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	JN698994	Mycobacterium phage DS6A, complete genome	42457-42488	8	0.75
NC_008554_19	19.53\|3492224\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492224-3492255	32	NZ_CP044976	Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2) plasmid pPBL-H3_B2-1, complete sequence	191547-191578	8	0.75
NC_008554_19	19.53\|3492224\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492224-3492255	32	NZ_CP050100	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b3, complete sequence	202752-202783	8	0.75
NC_008554_19	19.53\|3492224\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492224-3492255	32	NZ_CP025017	Rhizobium leguminosarum strain Norway plasmid pRLN5, complete sequence	183728-183759	8	0.75
NC_008554_19	19.53\|3492224\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492224-3492255	32	NC_012854	Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132505, complete sequence	129107-129138	8	0.75
NC_008554_19	19.53\|3492224\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492224-3492255	32	NZ_CP053443	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eC, complete sequence	165585-165616	8	0.75
NC_008554_19	19.54\|3492285\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492285-3492316	32	MN693712	Marine virus AFVG_250M462, complete genome	35546-35577	8	0.75
NC_008554_19	19.56\|3492408\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492408-3492439	32	NC_019957	Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence	82448-82479	8	0.75
NC_008554_19	19.57\|3492469\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492469-3492500	32	NC_048709	Vibrio phage YC, complete genome	21244-21275	8	0.75
NC_008554_19	19.59\|3492591\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492591-3492622	32	NZ_CP017750	Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence	249723-249754	8	0.75
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	NZ_CP046704	Nostoc sp. ATCC 53789 plasmid pNsp_a, complete sequence	65505-65536	8	0.75
NC_008554_19	19.67\|3493079\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493079-3493110	32	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	227261-227292	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MT498048	Mycobacterium phage Raymond7, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MK524522	Mycobacterium phage Purgamenstris, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MT684588	Mycobacterium phage Snekmaggedon, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MT498042	Mycobacterium phage Rebel, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MT498044	Mycobacterium phage Jamie19, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MK392367	Mycobacterium phage BabeRuth, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MK524520	Mycobacterium phage Nenae, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	JN624851	Mycobacterium phage Redi, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	KU935727	Mycobacterium phage Panchino, complete genome	11673-11704	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	KU935729	Mycobacterium phage SkinnyPete, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MK524509	Mycobacterium phage SpongeBob, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	MK524528	Mycobacterium phage ShrimpFriedEgg, complete genome	11697-11728	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	NZ_CP042167	Burkholderia contaminans strain ZCC plasmid unnamed1, complete sequence	34881-34912	8	0.75
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	NZ_CP046610	Burkholderia contaminans strain XL73 plasmid unnamed1, complete sequence	104209-104240	8	0.75
NC_008554_19	19.78\|3493751\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493751-3493782	32	CP053333	Salmonella enterica subsp. diarizonae serovar 47:k:z35 strain 2009K1094 plasmid unnamed1, complete sequence	30248-30279	8	0.75
NC_008554_9	9.1\|1571289\|32\|NC_008554\|CRISPRCasFinder	1571289-1571320	32	NZ_CP024609	Massilia violaceinigra strain B2 plasmid unnamed, complete sequence	75331-75362	9	0.719
NC_008554_10	10.18\|1685389\|37\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	1685389-1685425	37	MN586029	Mycobacterium phage Hannaconda, complete genome	2782-2818	9	0.757
NC_008554_10	10.18\|1685389\|37\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	1685389-1685425	37	NC_004688	Mycobacterium phage Omega, complete genome	5826-5862	9	0.757
NC_008554_10	10.18\|1685389\|37\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	1685389-1685425	37	AY129338	Mycobacterium virus Omega, complete genome	5826-5862	9	0.757
NC_008554_19	19.11\|3489662\|32\|NC_008554\|CRISPRCasFinder,CRT	3489662-3489693	32	MG592537	Vibrio phage 1.170.O._10N.261.52.C3, partial genome	35625-35656	9	0.719
NC_008554_19	19.12\|3489723\|32\|NC_008554\|CRISPRCasFinder,CRT	3489723-3489754	32	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	85827-85858	9	0.719
NC_008554_19	19.18\|3490089\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490089-3490120	32	MN234194	Arthrobacter phage Loretta, complete genome	41152-41183	9	0.719
NC_008554_19	19.18\|3490089\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490089-3490120	32	MN234168	Arthrobacter phage Ingrid, complete genome	41152-41183	9	0.719
NC_008554_19	19.18\|3490089\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490089-3490120	32	NC_003903	Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence	266006-266037	9	0.719
NC_008554_19	19.18\|3490089\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490089-3490120	32	NC_000902	Enterobacteria phage VT2-Sakai, complete genome	40724-40755	9	0.719
NC_008554_19	19.18\|3490089\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490089-3490120	32	AP000363	Enterobacteria phage VT2-Sakai proviral DNA, complete genome	40724-40755	9	0.719
NC_008554_19	19.19\|3490150\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490150-3490181	32	NZ_CP019938	Ketogulonicigenium robustum strain SPU_B003 plasmid unnamed1, complete sequence	5314-5345	9	0.719
NC_008554_19	19.20\|3490211\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490211-3490242	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1423783-1423814	9	0.719
NC_008554_19	19.20\|3490211\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490211-3490242	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	389474-389505	9	0.719
NC_008554_19	19.21\|3490272\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490272-3490303	32	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	204909-204940	9	0.719
NC_008554_19	19.27\|3490638\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490638-3490669	32	NZ_CP013631	Rhizobium sp. N324 plasmid pRspN324a, complete sequence	163855-163886	9	0.719
NC_008554_19	19.32\|3490943\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490943-3490974	32	NZ_CP013631	Rhizobium sp. N324 plasmid pRspN324a, complete sequence	163855-163886	9	0.719
NC_008554_19	19.33\|3491004\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491004-3491035	32	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	479808-479839	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	379871-379902	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP025505	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvC, complete sequence	146690-146721	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP016290	Rhizobium leguminosarum strain Vaf10 plasmid unnamed3, complete sequence	500739-500770	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP030762	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed2, complete sequence	15067-15098	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NC_019408	Caulobacter phage CcrRogue, complete genome	76111-76142	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	MF373841	Mycobacterium phage Hurricane, complete genome	24729-24760	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	KX397369	Erwinia phage vB_EamM_Kwan, complete genome	210262-210293	9	0.719
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NC_048016	Erwinia phage Wellington, complete genome	208414-208445	9	0.719
NC_008554_19	19.41\|3491492\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491492-3491523	32	NZ_CP039048	Piscirickettsia salmonis strain Psal-073 plasmid unnamed2, complete sequence	10294-10325	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	379871-379902	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP025505	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvC, complete sequence	146690-146721	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP016290	Rhizobium leguminosarum strain Vaf10 plasmid unnamed3, complete sequence	500739-500770	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP030762	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed2, complete sequence	15067-15098	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NC_019408	Caulobacter phage CcrRogue, complete genome	76111-76142	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	MF373841	Mycobacterium phage Hurricane, complete genome	24729-24760	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	KX397369	Erwinia phage vB_EamM_Kwan, complete genome	210262-210293	9	0.719
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NC_048016	Erwinia phage Wellington, complete genome	208414-208445	9	0.719
NC_008554_19	19.43\|3491614\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491614-3491645	32	NZ_CP039048	Piscirickettsia salmonis strain Psal-073 plasmid unnamed2, complete sequence	10294-10325	9	0.719
NC_008554_19	19.55\|3492346\|33\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492346-3492378	33	NZ_CP014514	Frondihabitans sp. PAMC 28766 strain SR6 plasmid 1, complete sequence	44499-44531	9	0.727
NC_008554_19	19.55\|3492346\|33\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492346-3492378	33	NC_016110	Streptomyces pratensis ATCC 33331 plasmid pSFLA01, complete sequence	12961-12993	9	0.727
NC_008554_19	19.56\|3492408\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492408-3492439	32	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	86247-86278	9	0.719
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	KM507819	Escherichia phage 121Q, complete genome	28837-28868	9	0.719
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	MN871446	UNVERIFIED: Serratia phage KpLz-2_45, complete genome	75221-75252	9	0.719
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	MN871447	UNVERIFIED: Serratia phage KpLz_1_41, complete genome	142856-142887	9	0.719
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	MN871449	UNVERIFIED: Serratia phage KpXa_1, complete genome	114614-114645	9	0.719
NC_008554_19	19.58\|3492530\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492530-3492561	32	MN871451	UNVERIFIED: Serratia phage KpYy_2_45, complete genome	164676-164707	9	0.719
NC_008554_19	19.59\|3492591\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492591-3492622	32	NC_024123	Pseudomonas phage KPP25 DNA, complete sequence	42019-42050	9	0.719
NC_008554_19	19.62\|3492774\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492774-3492805	32	MG839027	Microbacterium phage Eleri, complete genome	28954-28985	9	0.719
NC_008554_19	19.63\|3492835\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492835-3492866	32	NZ_CP051517	Paraburkholderia aromaticivorans strain AR20-38 plasmid unnamed1	116176-116207	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	LR746310	Klebsiella phage vB_KpnM_05F genome assembly, chromosome: 1	155260-155291	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	MN101223	Klebsiella phage KOX10, complete genome	19023-19054	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	MT157285	Klebsiella phage P-KP2, complete genome	6413-6444	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	KT001919	Klebsiella phage Miro, complete genome	144056-144087	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	HQ918180	Klebsiella phage KP27, complete genome	140834-140865	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	KT001918	Klebsiella phage Matisse, complete genome	143854-143885	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	KX130727	Escherichia phage phT4A, partial genome	136974-137005	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	MN101221	Klebsiella phage KOX8, complete genome	19004-19035	9	0.719
NC_008554_19	19.64\|3492896\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492896-3492927	32	GU295964	Klebsiella phage KP15, complete genome	142235-142266	9	0.719
NC_008554_19	19.67\|3493079\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493079-3493110	32	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	602036-602067	9	0.719
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	KU935731	Mycobacterium phage Phrann, complete genome	11697-11728	9	0.719
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	KX756439	Mycobacterium phage PhancyPhin, complete genome	11697-11728	9	0.719
NC_008554_19	19.7\|3489418\|32\|NC_008554\|CRISPRCasFinder,CRT	3489418-3489449	32	NZ_CP017077	Novosphingobium resinovorum strain SA1 plasmid pSA2, complete sequence	17104-17135	10	0.688
NC_008554_19	19.20\|3490211\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490211-3490242	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	428685-428716	10	0.688
NC_008554_19	19.20\|3490211\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490211-3490242	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1384383-1384414	10	0.688
NC_008554_19	19.37\|3491248\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491248-3491279	32	MK411820	Acinetobacter phage vB_AbaS_D0, complete genome	8418-8449	10	0.688
NC_008554_19	19.37\|3491248\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491248-3491279	32	MG366115	UNVERIFIED: Acinetobacter phage PBAB25, complete genome	36606-36637	10	0.688
NC_008554_19	19.37\|3491248\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491248-3491279	32	NC_023590	Acinetobacter phage IME_AB3, complete genome	39161-39192	10	0.688
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP035424	Leisingera sp. NJS204 plasmid unnamed7, complete sequence	33149-33180	10	0.688
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP038239	Leisingera sp. NJS201 plasmid unnamed5, complete sequence	47618-47649	10	0.688
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1273355-1273386	10	0.688
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	2110553-2110584	10	0.688
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP035424	Leisingera sp. NJS204 plasmid unnamed7, complete sequence	33149-33180	10	0.688
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP038239	Leisingera sp. NJS201 plasmid unnamed5, complete sequence	47618-47649	10	0.688
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1273355-1273386	10	0.688
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	2110553-2110584	10	0.688
NC_008554_19	19.52\|3492163\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492163-3492194	32	NC_048860	Microbacterium phage Arete, complete genome	49486-49517	10	0.688
NC_008554_19	19.53\|3492224\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492224-3492255	32	NC_023283	Streptomyces sp. FR1 plasmid pFRL3, complete sequence	277296-277327	10	0.688
NC_008554_19	19.54\|3492285\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492285-3492316	32	MK448723	Streptococcus phage Javan271, complete genome	25031-25062	10	0.688
NC_008554_19	19.54\|3492285\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492285-3492316	32	MK448746	Streptococcus phage Javan383, complete genome	26126-26157	10	0.688
NC_008554_19	19.59\|3492591\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492591-3492622	32	NC_041964	Pseudomonas phage R18 DNA, complete genome	22039-22070	10	0.688
NC_008554_19	19.66\|3493018\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493018-3493049	32	NZ_CP007798	Azospirillum brasilense strain Az39 plasmid AbAZ39_p5, complete sequence	48059-48090	10	0.688
NC_008554_19	19.67\|3493079\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493079-3493110	32	NZ_LR723673	Rhizobium flavum strain YW14 plasmid 4	56663-56694	10	0.688
NC_008554_19	19.67\|3493079\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493079-3493110	32	NZ_CP015009	Aminobacter aminovorans strain KCTC 2477 plasmid pAA04, complete sequence	110327-110358	10	0.688
NC_008554_19	19.67\|3493079\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493079-3493110	32	NC_006362	Nocardia farcinica IFM 10152 plasmid pNF1, complete sequence	155589-155620	10	0.688
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	NZ_CP028228	Lactobacillus plantarum strain SRCM101187 plasmid unnamed2, complete sequence	34284-34315	10	0.688
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	NZ_CP035561	Lactobacillus plantarum strain SRCM103297 plasmid unnamed5	33647-33678	10	0.688
NC_008554_19	19.68\|3493140\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493140-3493171	32	NZ_CP035158	Lactobacillus plantarum strain SRCM103362 plasmid unnamed2	2981-3012	10	0.688
NC_008554_19	19.73\|3493445\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493445-3493476	32	NZ_CP032924	Agrobacterium tumefaciens strain 1D1108 plasmid pAt1D1108b, complete sequence	157633-157664	10	0.688
NC_008554_10	10.23\|1685753\|35\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	1685753-1685787	35	NZ_CP021119	Streptomyces sp. CLI2509 strain CLI2905 plasmid unnamed1, complete sequence	30171-30205	11	0.686
NC_008554_19	19.27\|3490638\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490638-3490669	32	NZ_CP049244	Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence	453546-453577	11	0.656
NC_008554_19	19.32\|3490943\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3490943-3490974	32	NZ_CP049244	Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence	453546-453577	11	0.656
NC_008554_19	19.40\|3491431\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491431-3491462	32	NZ_CP020716	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence	47385-47416	11	0.656
NC_008554_19	19.42\|3491553\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3491553-3491584	32	NZ_CP020716	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence	47385-47416	11	0.656
NC_008554_19	19.54\|3492285\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3492285-3492316	32	MN692948	Marine virus AFVG_117M19, complete genome	58757-58788	11	0.656
NC_008554_19	19.70\|3493262\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493262-3493293	32	NZ_CP045074	Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence	382421-382452	11	0.656
NC_008554_19	19.71\|3493323\|32\|NC_008554\|CRISPRCasFinder,CRT,PILER-CR	3493323-3493354	32	NZ_CP045074	Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence	382421-382452	11	0.656

1. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to KM389238 (UNVERIFIED: Pseudomonas phage F_HA1208sp/Pa1651 clone contig00002 genomic sequence) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

2. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MH719191 (Pseudomonas phage Fc22, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

3. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to NC_006548 (Pseudomonas phage B3, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

4. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MK511059 (Pseudomonas phage CF78, partial genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

5. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to AF232233 (Bacteriophage B3, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

6. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MK511061 (Pseudomonas phage CF125, partial genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

7. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to JX495043 (Pseudomonas phage JBD67, partial genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

8. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MK511057 (Pseudomonas phage CF5, partial genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

9. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to LN898172 (Pseudomonas phage vB_PaeS_PM105) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

10. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MK511063 (Pseudomonas phage CF177, partial genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

11. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MH719189 (Pseudomonas phage Fc02, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

12. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MK934841 (Pseudomonas phage UMP151, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

13. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to MH719193 (Pseudomonas phage H72, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

14. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to JX495041 (Pseudomonas phage JBD18, complete genome) position: , mismatch: 6, identity: 0.818

acatcaaccggctggtgggccgcatcaaggggc--	CRISPR spacer
acgtcaaccggctggtgtgccgcat--agctgcca	Protospacer
**.************** *******  **  **

15. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012032 (Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence) position: , mismatch: 6, identity: 0.812

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
aaatcaaaacattgaataacttggattgaaag	Protospacer
***   ** ********* ************

16. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP043499 (Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.812

ttgcgccgctttttgcgccatgcc---ctccaggc	CRISPR spacer
ttgcgccgcttctcgcgccatgccgcgctcaa---	Protospacer
***********.*.**********   *** *

17. spacer 19.69|3493201|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_016108 (Methylomicrobium alcaliphilum 20Z plasmid MEALZ_p, complete sequence) position: , mismatch: 6, identity: 0.812

aaaaagcagcaactgagcgatttggaggcgaa	CRISPR spacer
atcgagcggcaactgagcgaattggaggcgac	Protospacer
*  .***.************ **********

18. spacer 3.1|485117|33|NC_008554|CRISPRCasFinder matches to NZ_CP012918 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p4, complete sequence) position: , mismatch: 7, identity: 0.788

acatcaaccggctggtgggccgcatcaaggggc	CRISPR spacer
acctggaccggctggagggccggatcaaggcgg	Protospacer
** * .********* ****** ******* *

19. spacer 19.5|3489296|32|NC_008554|CRISPRCasFinder,CRT matches to NZ_CP045122 (Rubrobacter sp. SCSIO 52915 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

gccggagctcatccgggccgcatcggaagtgc	CRISPR spacer
cccggagctcatccgggccgcctcgagcgtcg	Protospacer
 ******************** ***.. **

20. spacer 19.8|3489479|32|NC_008554|CRISPRCasFinder,CRT matches to MK295205 (Shigella phage vB_SflM_004, complete genome) position: , mismatch: 7, identity: 0.781

gtctggttcggtggggtgtggtctggtccggt	CRISPR spacer
gttcggttcggttgggtgtggtatggtggtgt	Protospacer
**..******** ********* ****   **

21. spacer 19.14|3489845|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021802 (Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence) position: , mismatch: 7, identity: 0.781

tggacaggatgaagagcagaaccttctgccgg	CRISPR spacer
agggcaggatgaagaacagaaccttcgtctga	Protospacer
 **.***********.**********  *.*.

22. spacer 19.34|3491065|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.781

accacgtcccaggggaacccggggttgtgggt	CRISPR spacer
acgtcgtcccaggtgaacccggcgttgttgac	Protospacer
**  ********* ******** ***** *..

23. spacer 19.34|3491065|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 7, identity: 0.781

accacgtcccaggggaacccggggttgtgggt	CRISPR spacer
acgtcgtcccaggtgaacccggcgttgttgac	Protospacer
**  ********* ******** ***** *..

24. spacer 19.41|3491492|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024792 (Nostoc flagelliforme CCNUN1 plasmid pNFSY07, complete sequence) position: , mismatch: 7, identity: 0.781

acgccttggtatatatggtctgctgcttcggg	CRISPR spacer
aatgctttgtataaatggtctgctgcttccga	Protospacer
*   *** ***** *************** *.

25. spacer 19.43|3491614|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024792 (Nostoc flagelliforme CCNUN1 plasmid pNFSY07, complete sequence) position: , mismatch: 7, identity: 0.781

acgccttggtatatatggtctgctgcttcggg	CRISPR spacer
aatgctttgtataaatggtctgctgcttccga	Protospacer
*   *** ***** *************** *.

26. spacer 19.52|3492163|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN908690 (Microbacterium phage Hubbs, complete genome) position: , mismatch: 7, identity: 0.781

tcatggctggcatccagatctaccaggagcgg	CRISPR spacer
tcatggctggcacccacatctaccacccgggt	Protospacer
************.*** ********   * *

27. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017949 (Tenericutes bacterium MO-XQ plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.781

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
aggagttatcatggaatattttggattgaaat	Protospacer
*...*. ***** ******.************

28. spacer 19.60|3492652|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR594663 (Variovorax sp. RA8 plasmid 2) position: , mismatch: 7, identity: 0.781

accccgtggccgaccaggtgcagggattccgg---	CRISPR spacer
gccgcgaggccgaccaggtgcagg---tccagaag	Protospacer
.** ** *****************   ***.*

29. spacer 19.78|3493751|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046724 (Pantoea agglomerans strain ASB05 plasmid pASB05p2, complete sequence) position: , mismatch: 7, identity: 0.781

ccccggcgcggacgtccgagaaagggataacc	CRISPR spacer
cgccggcgcgggcgtccgacaaaggaagagca	Protospacer
* *********.******* *****.* *.*

30. spacer 19.78|3493751|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034471 (Pantoea agglomerans strain CFSAN047153 plasmid pCFSAN047153_2, complete sequence) position: , mismatch: 7, identity: 0.781

ccccggcgcggacgtccgagaaagggataacc	CRISPR spacer
cgccggcgcgggcgtccgacaaaggaagagca	Protospacer
* *********.******* *****.* *.*

31. spacer 19.78|3493751|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034476 (Pantoea agglomerans strain CFSAN047154 plasmid pCFSAN047154_2, complete sequence) position: , mismatch: 7, identity: 0.781

ccccggcgcggacgtccgagaaagggataacc	CRISPR spacer
cgccggcgcgggcgtccgacaaaggaagagca	Protospacer
* *********.******* *****.* *.*

32. spacer 20.1|4030485|29|NC_008554|CRISPRCasFinder matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 7, identity: 0.759

atctctggagcttctcaggcaaagaagga	CRISPR spacer
aggtttggagcttctcaggcaaaaaaccg	Protospacer
*  *.******************.**  .

33. spacer 18.1|3478615|31|NC_008554|PILER-CR matches to NZ_CP018784 (Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence) position: , mismatch: 8, identity: 0.742

tccccaacgtccacgaagagccgcgcgggaa	CRISPR spacer
tcggtgccgtccacgaggatccgcgcgggac	Protospacer
**  .. *********.** **********

34. spacer 18.1|3478615|31|NC_008554|PILER-CR matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.742

tccccaacgtccacgaagagccgc-----gcgggaa	CRISPR spacer
gccccaacgtccaggaagggccgccacttgc-----	Protospacer
 ************ ****.*****     **

35. spacer 18.1|3478615|31|NC_008554|PILER-CR matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 8, identity: 0.742

tccccaacgtccacgaagagccgc-----gcgggaa	CRISPR spacer
gccccaacgtccaggaagggccgccacttgc-----	Protospacer
 ************ ****.*****     **

36. spacer 19.12|3489723|32|NC_008554|CRISPRCasFinder,CRT matches to NC_009620 (Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence) position: , mismatch: 8, identity: 0.75

--agctattccccggaccccgcgaaaatcgagga	CRISPR spacer
ctgaccgtt--ccggtccccgcgaacatcgagga	Protospacer
  ..*..**  **** ********* ********

37. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP032755 (Lactobacillus plantarum subsp. argentoratensis strain DSM 16365 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

38. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP030091 (Lactobacillus reuteri strain YSJL-12 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

39. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053340 (Lactobacillus paraplantarum strain CK401 plasmid pCK401C, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

40. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017376 (Lactobacillus plantarum strain TMW 1.708 plasmid pL1708-2, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

41. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040905 (Enterococcus faecium strain N56454 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

42. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_022618 (Staphylococcus epidermidis plasmid pSWS47, isolate 47, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

43. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_019371 (Lactobacillus plantarum plasmid pG6303, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

44. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_021517 (Lactobacillus plantarum 16 plasmid Lp16E, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

45. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028230 (Lactobacillus plantarum strain SRCM101222 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

46. spacer 19.15|3489906|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_016607 (Pediococcus claussenii ATCC BAA-344 plasmid pPECL-4, complete sequence) position: , mismatch: 8, identity: 0.75

gccaatgtgaaccgcatctttttg-attctatc	CRISPR spacer
cgcaatatgaaccgcttctttttgaacggtat-	Protospacer
  ****.******** ******** *.  ***

47. spacer 19.19|3490150|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.75

atccctcagccatggtttgacgccgaacacga	CRISPR spacer
cacctgcagcgatggcttgacgccgaacaccg	Protospacer
  **. **** ****.************** .

48. spacer 19.19|3490150|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 8, identity: 0.75

atccctcagccatggtttgacgccgaacacga	CRISPR spacer
cacctgcagcgatggcttgacgccgaacaccg	Protospacer
  **. **** ****.************** .

49. spacer 19.20|3490211|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP041045 (Paracoccus sp. AK26 plasmid pAK1, complete sequence) position: , mismatch: 8, identity: 0.75

gctccccggcccggcgcaacggaacgccacga	CRISPR spacer
ggttcatggcccggcgcaacgaagcgccaccg	Protospacer
* *.* .**************.*.****** .

50. spacer 19.29|3490760|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to HQ634195 (Vibrio phage eugene 12A10 genomic sequence) position: , mismatch: 8, identity: 0.75

---ggcgaactacaaaaaccaacagtaggaggatc	CRISPR spacer
tctggtaa---acaaaaacaaacattaggaggata	Protospacer
   **..*   ******** **** *********

51. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024425 (Paracoccus yeei strain TT13 plasmid pTT13-3, complete sequence) position: , mismatch: 8, identity: 0.75

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
atcggccgttgccaccccaaccgccgccaatg	Protospacer
**.* .**.****************.***  .

52. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to U46938 (Mycobacterium phage DS6A, Spe1/NheI G fragment sequence) position: , mismatch: 8, identity: 0.75

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgtgttcggtgacaccccaaccgcctcggcga	Protospacer
  ****** ** ************* * .*.*

53. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to JN698994 (Mycobacterium phage DS6A, complete genome) position: , mismatch: 8, identity: 0.75

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgtgttcggtgacaccccaaccgcctcggcga	Protospacer
  ****** ** ************* * .*.*

54. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024425 (Paracoccus yeei strain TT13 plasmid pTT13-3, complete sequence) position: , mismatch: 8, identity: 0.75

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
atcggccgttgccaccccaaccgccgccaatg	Protospacer
**.* .**.****************.***  .

55. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to U46938 (Mycobacterium phage DS6A, Spe1/NheI G fragment sequence) position: , mismatch: 8, identity: 0.75

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgtgttcggtgacaccccaaccgcctcggcga	Protospacer
  ****** ** ************* * .*.*

56. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to JN698994 (Mycobacterium phage DS6A, complete genome) position: , mismatch: 8, identity: 0.75

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgtgttcggtgacaccccaaccgcctcggcga	Protospacer
  ****** ** ************* * .*.*

57. spacer 19.53|3492224|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP044976 (Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2) plasmid pPBL-H3_B2-1, complete sequence) position: , mismatch: 8, identity: 0.75

cccgaatacgtgcgcgacctcgtggcactgca	CRISPR spacer
accacctacgtgcgcgacctcctggcgctgat	Protospacer
 **.  *************** ****.***

58. spacer 19.53|3492224|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP050100 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b3, complete sequence) position: , mismatch: 8, identity: 0.75

cccgaata---cgtgcgcgacctcgtggcactgca	CRISPR spacer
---ggaaatgccgtccgcgaccttgtggcactgcc	Protospacer
   *.* *   *** ********.**********

59. spacer 19.53|3492224|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025017 (Rhizobium leguminosarum strain Norway plasmid pRLN5, complete sequence) position: , mismatch: 8, identity: 0.75

cccgaata---cgtgcgcgacctcgtggcactgca	CRISPR spacer
---ggaaatgccgtccgcgaccttgtggcactgcc	Protospacer
   *.* *   *** ********.**********

60. spacer 19.53|3492224|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_012854 (Rhizobium leguminosarum bv. trifolii WSM1325 plasmid pR132505, complete sequence) position: , mismatch: 8, identity: 0.75

cccgaata---cgtgcgcgacctcgtggcactgca	CRISPR spacer
---ggaaatgccgtccgcgaccttgtggcactgcc	Protospacer
   *.* *   *** ********.**********

61. spacer 19.53|3492224|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053443 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eC, complete sequence) position: , mismatch: 8, identity: 0.75

cccgaata---cgtgcgcgacctcgtggcactgca	CRISPR spacer
---ggaaatgccgtccgcgaccttgtggcactgcc	Protospacer
   *.* *   *** ********.**********

62. spacer 19.54|3492285|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN693712 (Marine virus AFVG_250M462, complete genome) position: , mismatch: 8, identity: 0.75

cgcagaggaggtggacaatggctgatcgcgtg-	CRISPR spacer
gaaagagggagtggacaatggctgat-gcttat	Protospacer
 . *****..**************** ** *.

63. spacer 19.56|3492408|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_019957 (Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence) position: , mismatch: 8, identity: 0.75

gattg--cacggcggacccggtaaccggcggcaa	CRISPR spacer
--ctggtcgtggccgacccggtcaccggcggcac	Protospacer
  .**  *..*** ******** **********

64. spacer 19.57|3492469|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_048709 (Vibrio phage YC, complete genome) position: , mismatch: 8, identity: 0.75

ccatcgacgcctattttgaggagcaggtctca	CRISPR spacer
aagccgacgcctattttaaggagctggtatga	Protospacer
  ..*************.****** *** * *

65. spacer 19.59|3492591|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017750 (Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ctcaccggcaccatgcgtgagcagtacgaagt	CRISPR spacer
gacgccggcgccatgcgtcagcagtacgccga	Protospacer
  *.*****.******** *********  *

66. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046704 (Nostoc sp. ATCC 53789 plasmid pNsp_a, complete sequence) position: , mismatch: 8, identity: 0.75

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tcttcattctctggcagaaaccctggaaaaca	Protospacer
 * ******.*****.************..

67. spacer 19.67|3493079|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 8, identity: 0.75

--cggcccggcgagctcccaggccacgtgccgta	CRISPR spacer
atcga--cagcgagttcccaggccacgagccgct	Protospacer
  **.  *.*****.************ ****.

68. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MT498048 (Mycobacterium phage Raymond7, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

69. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK524522 (Mycobacterium phage Purgamenstris, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

70. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MT684588 (Mycobacterium phage Snekmaggedon, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

71. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MT498042 (Mycobacterium phage Rebel, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

72. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MT498044 (Mycobacterium phage Jamie19, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

73. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK392367 (Mycobacterium phage BabeRuth, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

74. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK524520 (Mycobacterium phage Nenae, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

75. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to JN624851 (Mycobacterium phage Redi, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

76. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KU935727 (Mycobacterium phage Panchino, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

77. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KU935729 (Mycobacterium phage SkinnyPete, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

78. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK524509 (Mycobacterium phage SpongeBob, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

79. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK524528 (Mycobacterium phage ShrimpFriedEgg, complete genome) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttttgcgccatgccctcgaacc	Protospacer
 .  ***** ***************** *. *

80. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP042167 (Burkholderia contaminans strain ZCC plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
gggcgccgctttttgcgccgtgaccatcgcgc	Protospacer
  *****************.** ** .*. **

81. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046610 (Burkholderia contaminans strain XL73 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
gggcgccgctttttgcgccgtgaccatcgcgc	Protospacer
  *****************.** ** .*. **

82. spacer 19.78|3493751|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to CP053333 (Salmonella enterica subsp. diarizonae serovar 47:k:z35 strain 2009K1094 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ccccggcgcggacgtccgagaaagggataacc	CRISPR spacer
agccggcgcagacgtccgagagagggtgtatc	Protospacer
  *******.***********.****   *.*

83. spacer 9.1|1571289|32|NC_008554|CRISPRCasFinder matches to NZ_CP024609 (Massilia violaceinigra strain B2 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.719

-gtaccccaccagtaaaccatcagttcaacgcc	CRISPR spacer
cata-accaccagtaaaccatcaattgaatcat	Protospacer
 .**  *****************.** **.  .

84. spacer 10.18|1685389|37|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN586029 (Mycobacterium phage Hannaconda, complete genome) position: , mismatch: 9, identity: 0.757

atgtcccggtcgagcatctcgatgctctccgggtact	CRISPR spacer
ttgggcccgtcgaggatctcgatgctctccgcgccgt	Protospacer
 **  ** ****** **************** *.  *

85. spacer 10.18|1685389|37|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_004688 (Mycobacterium phage Omega, complete genome) position: , mismatch: 9, identity: 0.757

atgtcccggtcgagcatctcgatgctctccgggtact	CRISPR spacer
ttgggcccgtcgaggatctcgatgctctccgcgccgt	Protospacer
 **  ** ****** **************** *.  *

86. spacer 10.18|1685389|37|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to AY129338 (Mycobacterium virus Omega, complete genome) position: , mismatch: 9, identity: 0.757

atgtcccggtcgagcatctcgatgctctccgggtact	CRISPR spacer
ttgggcccgtcgaggatctcgatgctctccgcgccgt	Protospacer
 **  ** ****** **************** *.  *

87. spacer 19.11|3489662|32|NC_008554|CRISPRCasFinder,CRT matches to MG592537 (Vibrio phage 1.170.O._10N.261.52.C3, partial genome) position: , mismatch: 9, identity: 0.719

cagtttaaccagttgagcaaatattttccacg	CRISPR spacer
atatttaaccagttgactaaatatttatcaaa	Protospacer
  .************* .******** .** .

88. spacer 19.12|3489723|32|NC_008554|CRISPRCasFinder,CRT matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

agctattccccggaccccgcgaaaatcgagga	CRISPR spacer
ggggcgaccccggacccctcgaaaatcggggc	Protospacer
.*     *********** *********.**

89. spacer 19.18|3490089|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN234194 (Arthrobacter phage Loretta, complete genome) position: , mismatch: 9, identity: 0.719

atccttgagaacgtccctcgtggtggcggtac	CRISPR spacer
attcttgagaacgtccttcgtggttgtcacgt	Protospacer
**.*************.******* *. ....

90. spacer 19.18|3490089|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN234168 (Arthrobacter phage Ingrid, complete genome) position: , mismatch: 9, identity: 0.719

atccttgagaacgtccctcgtggtggcggtac	CRISPR spacer
attcttgagaacgtccttcgtggttgtcacgt	Protospacer
**.*************.******* *. ....

91. spacer 19.18|3490089|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_003903 (Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence) position: , mismatch: 9, identity: 0.719

atccttgagaacgtccctcgtggtggcggtac	CRISPR spacer
ccccggcagaccgtccctcgtggtgacggtga	Protospacer
 .**   *** **************.****.

92. spacer 19.18|3490089|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_000902 (Enterobacteria phage VT2-Sakai, complete genome) position: , mismatch: 9, identity: 0.719

atccttgagaacgtccctcgtggtggcggtac	CRISPR spacer
tccgctgagaacgtcactggtggtggcgacaa	Protospacer
 .* .********** ** *********..*

93. spacer 19.18|3490089|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to AP000363 (Enterobacteria phage VT2-Sakai proviral DNA, complete genome) position: , mismatch: 9, identity: 0.719

atccttgagaacgtccctcgtggtggcggtac	CRISPR spacer
tccgctgagaacgtcactggtggtggcgacaa	Protospacer
 .* .********** ** *********..*

94. spacer 19.19|3490150|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019938 (Ketogulonicigenium robustum strain SPU_B003 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

atccctcagccatggtttgacgccgaacacga	CRISPR spacer
attgtcgagccatggttcgacgtcgaacaccg	Protospacer
**. .. **********.****.******* .

95. spacer 19.20|3490211|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 9, identity: 0.719

gctccccggcccggcgcaacggaacgccacga	CRISPR spacer
gtcggccggcccggcgcaacggttcgccctgg	Protospacer
*..  *****************  **** .*.

96. spacer 19.20|3490211|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 9, identity: 0.719

gctccccggcccggcgcaacggaacgccacga	CRISPR spacer
gtcggccggcccggcgcaacggttcgccctgg	Protospacer
*..  *****************  **** .*.

97. spacer 19.21|3490272|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 9, identity: 0.719

ggacaggatgccccatcaggaagggcacccag	CRISPR spacer
cgaccggatgccccatctggaaggaaggcgcg	Protospacer
 *** ************ ******. . *  *

98. spacer 19.27|3490638|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013631 (Rhizobium sp. N324 plasmid pRspN324a, complete sequence) position: , mismatch: 9, identity: 0.719

tgcttggcgatatggaggcaaagatcgccggt	CRISPR spacer
agatcaaagagatcgaggcaaagatcgccggc	Protospacer
 * *... ** ** *****************.

99. spacer 19.32|3490943|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013631 (Rhizobium sp. N324 plasmid pRspN324a, complete sequence) position: , mismatch: 9, identity: 0.719

tgcttggcgatatggaggcaaagatcgccggt	CRISPR spacer
agatcaaagagatcgaggcaaagatcgccggc	Protospacer
 * *... ** ** *****************.

100. spacer 19.33|3491004|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 9, identity: 0.719

atcatcaattcacggggaaagtcc-ttaccgtg	CRISPR spacer
catatcaattcatggagaaagtcctttgtcgc-	Protospacer
  .*********.**.******** **..**.

101. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gagtatcgccgccaccccaaccgtcaccaccg	Protospacer
.    ****.*************.****** .

102. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025505 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvC, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gaatatcgccgccaccccaaccgtcaccaccg	Protospacer
.    ****.*************.****** .

103. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016290 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gagtatcgccgccaccccaaccgtcaccaccg	Protospacer
.    ****.*************.****** .

104. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP030762 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gaatatcgcagccaccccaaccgtcaccaccg	Protospacer
.    **** *************.****** .

105. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_019408 (Caulobacter phage CcrRogue, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgcgatagctgccacccccgccgccaccaccc	Protospacer
  .* * *********** .**********

106. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MF373841 (Mycobacterium phage Hurricane, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cctgcccgctgccgccccaaccgccgccattc	Protospacer
 .**..*******.***********.***.

107. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KX397369 (Erwinia phage vB_EamM_Kwan, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
tttcactgctgccattccaaccgccaccaccc	Protospacer
 **  ..*******..**************

108. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_048016 (Erwinia phage Wellington, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
tttcactgctgccattccaaccgccaccaccc	Protospacer
 **  ..*******..**************

109. spacer 19.41|3491492|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039048 (Piscirickettsia salmonis strain Psal-073 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

acgccttggtatatatggtctgctgcttcggg	CRISPR spacer
tagctatggtatttatggtctgctgtttctaa	Protospacer
  **. ****** ************.*** ..

110. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gagtatcgccgccaccccaaccgtcaccaccg	Protospacer
.    ****.*************.****** .

111. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025505 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvC, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gaatatcgccgccaccccaaccgtcaccaccg	Protospacer
.    ****.*************.****** .

112. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016290 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gagtatcgccgccaccccaaccgtcaccaccg	Protospacer
.    ****.*************.****** .

113. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP030762 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gaatatcgcagccaccccaaccgtcaccaccg	Protospacer
.    **** *************.****** .

114. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_019408 (Caulobacter phage CcrRogue, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgcgatagctgccacccccgccgccaccaccc	Protospacer
  .* * *********** .**********

115. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MF373841 (Mycobacterium phage Hurricane, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cctgcccgctgccgccccaaccgccgccattc	Protospacer
 .**..*******.***********.***.

116. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KX397369 (Erwinia phage vB_EamM_Kwan, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
tttcactgctgccattccaaccgccaccaccc	Protospacer
 **  ..*******..**************

117. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_048016 (Erwinia phage Wellington, complete genome) position: , mismatch: 9, identity: 0.719

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
tttcactgctgccattccaaccgccaccaccc	Protospacer
 **  ..*******..**************

118. spacer 19.43|3491614|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039048 (Piscirickettsia salmonis strain Psal-073 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

acgccttggtatatatggtctgctgcttcggg	CRISPR spacer
tagctatggtatttatggtctgctgtttctaa	Protospacer
  **. ****** ************.*** ..

119. spacer 19.55|3492346|33|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014514 (Frondihabitans sp. PAMC 28766 strain SR6 plasmid 1, complete sequence) position: , mismatch: 9, identity: 0.727

ggtttgag---ggggcgtcctgggcgaaggtgaccc	CRISPR spacer
---ccgcgaccggggcgtcatcggcgaaggtgaccg	Protospacer
   ..* *   ******** * *************

120. spacer 19.55|3492346|33|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_016110 (Streptomyces pratensis ATCC 33331 plasmid pSFLA01, complete sequence) position: , mismatch: 9, identity: 0.727

ggtttgagggggcgtcctgggcgaaggtgaccc	CRISPR spacer
gcagttgggaggcgtcctcggcgaaggtgacgt	Protospacer
*   * .**.******** ************ .

121. spacer 19.56|3492408|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

gattgcacggcggacccggtaaccggcggcaa	CRISPR spacer
gccttcacggcggaccccgtgaccggcgagcg	Protospacer
* .* ************ **.*******.  .

122. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KM507819 (Escherichia phage 121Q, complete genome) position: , mismatch: 9, identity: 0.719

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
ccttttaatcatttaatatcttgtattgaatt	Protospacer
     .******* ********* ****** *

123. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN871446 (UNVERIFIED: Serratia phage KpLz-2_45, complete genome) position: , mismatch: 9, identity: 0.719

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
taaactgatcattgaatatctgggaatgaatg	Protospacer
 **. ..************** *** ****

124. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN871447 (UNVERIFIED: Serratia phage KpLz_1_41, complete genome) position: , mismatch: 9, identity: 0.719

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
taaactgatcattgaatatctgggaatgaatg	Protospacer
 **. ..************** *** ****

125. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN871449 (UNVERIFIED: Serratia phage KpXa_1, complete genome) position: , mismatch: 9, identity: 0.719

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
taaactgatcattgaatatctgggaatgaatg	Protospacer
 **. ..************** *** ****

126. spacer 19.58|3492530|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN871451 (UNVERIFIED: Serratia phage KpYy_2_45, complete genome) position: , mismatch: 9, identity: 0.719

aaaggcaatcattgaatatcttggattgaaat	CRISPR spacer
taaactgatcattgaatatctgggaatgaatg	Protospacer
 **. ..************** *** ****

127. spacer 19.59|3492591|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_024123 (Pseudomonas phage KPP25 DNA, complete sequence) position: , mismatch: 9, identity: 0.719

ctcaccggcaccatgcgtgagcagtacgaagt	CRISPR spacer
ctcaccaacaccatgcgtgagcacatcgcttc	Protospacer
******..***************   **   .

128. spacer 19.62|3492774|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MG839027 (Microbacterium phage Eleri, complete genome) position: , mismatch: 9, identity: 0.719

ccgctctcccggagcaccttcccctcggaact	CRISPR spacer
aacgacccccggtgctccttcccctcggaacc	Protospacer
     *.***** ** ***************.

129. spacer 19.63|3492835|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP051517 (Paraburkholderia aromaticivorans strain AR20-38 plasmid unnamed1) position: , mismatch: 9, identity: 0.719

tgcgtcctctggactggacgcgagaaattgct	CRISPR spacer
cgcgtcctctggactgcaggcgagtacgcagt	Protospacer
.*************** * ***** *  .. *

130. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to LR746310 (Klebsiella phage vB_KpnM_05F genome assembly, chromosome: 1) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

131. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN101223 (Klebsiella phage KOX10, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
aggtattttccttgcggaaaccctggaagaaa	Protospacer
. **  **.*** ****************..

132. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MT157285 (Klebsiella phage P-KP2, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

133. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KT001919 (Klebsiella phage Miro, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
aggtattttccttgcggaaaccctggaagaaa	Protospacer
. **  **.*** ****************..

134. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to HQ918180 (Klebsiella phage KP27, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

135. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KT001918 (Klebsiella phage Matisse, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

136. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KX130727 (Escherichia phage phT4A, partial genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

137. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN101221 (Klebsiella phage KOX8, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

138. spacer 19.64|3492896|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to GU295964 (Klebsiella phage KP15, complete genome) position: , mismatch: 9, identity: 0.719

gcgtcattccctggcggaaaccctggaagggc	CRISPR spacer
tggtattttccttgcggaaaccctggaagaaa	Protospacer
  **  **.*** ****************..

139. spacer 19.67|3493079|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 9, identity: 0.719

cggcccggcgagctcccaggccacgtgccgta	CRISPR spacer
gacctccgcgagctcccgggccacgtcccggg	Protospacer
 . *.* **********.******** *** .

140. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KU935731 (Mycobacterium phage Phrann, complete genome) position: , mismatch: 9, identity: 0.719

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttctgcgccatgccctcgaacc	Protospacer
 .  ***** **.************** *. *

141. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to KX756439 (Mycobacterium phage PhancyPhin, complete genome) position: , mismatch: 9, identity: 0.719

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
accggccgcgttctgcgccatgccctcgaacc	Protospacer
 .  ***** **.************** *. *

142. spacer 19.7|3489418|32|NC_008554|CRISPRCasFinder,CRT matches to NZ_CP017077 (Novosphingobium resinovorum strain SA1 plasmid pSA2, complete sequence) position: , mismatch: 10, identity: 0.688

cttcctgtcggtccatggctatgtccactcaa	CRISPR spacer
gaacctgtcggtccaggcctatgtccgcaatc	Protospacer
   ************ * ********.*

143. spacer 19.20|3490211|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 10, identity: 0.688

gctccccggcccggcgcaacggaacgccacga	CRISPR spacer
cgaccccggcccggcgcaccgggacgacgatg	Protospacer
   *************** ***.*** *.  .

144. spacer 19.20|3490211|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 10, identity: 0.688

gctccccggcccggcgcaacggaacgccacga	CRISPR spacer
cgaccccggcccggcgcaccgggacgacgatg	Protospacer
   *************** ***.*** *.  .

145. spacer 19.37|3491248|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK411820 (Acinetobacter phage vB_AbaS_D0, complete genome) position: , mismatch: 10, identity: 0.688

ttcatccaaaacattccgttgagtggctttcg	CRISPR spacer
caagcccaaaacattgcgttgaatggcttgat	Protospacer
.  ..********** ******.******

146. spacer 19.37|3491248|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MG366115 (UNVERIFIED: Acinetobacter phage PBAB25, complete genome) position: , mismatch: 10, identity: 0.688

ttcatccaaaacattccgttgagtggctttcg	CRISPR spacer
caagcccaaaacattgcgttgaatggcttgat	Protospacer
.  ..********** ******.******

147. spacer 19.37|3491248|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_023590 (Acinetobacter phage IME_AB3, complete genome) position: , mismatch: 10, identity: 0.688

ttcatccaaaacattccgttgagtggctttcg	CRISPR spacer
caagcccaaaacattgcgttgaatggcttgat	Protospacer
.  ..********** ******.******

148. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP035424 (Leisingera sp. NJS204 plasmid unnamed7, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gtagttcgctgccacctcaaacgccatgcggg	Protospacer
.* *************.*** *****.   ..

149. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP038239 (Leisingera sp. NJS201 plasmid unnamed5, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gtagttcgctgccacctcaaacgccatgcggg	Protospacer
.* *************.*** *****.   ..

150. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgaaatcgctgccaccgccaccgccaccggca	Protospacer
   . *********** * *********.  *

151. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
ggccatggctgccaccgccaccgccaccaccg	Protospacer
. .  * ********* * *********** .

152. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP035424 (Leisingera sp. NJS204 plasmid unnamed7, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gtagttcgctgccacctcaaacgccatgcggg	Protospacer
.* *************.*** *****.   ..

153. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP038239 (Leisingera sp. NJS201 plasmid unnamed5, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
gtagttcgctgccacctcaaacgccatgcggg	Protospacer
.* *************.*** *****.   ..

154. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
cgaaatcgctgccaccgccaccgccaccggca	Protospacer
   . *********** * *********.  *

155. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
ggccatggctgccaccgccaccgccaccaccg	Protospacer
. .  * ********* * *********** .

156. spacer 19.52|3492163|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_048860 (Microbacterium phage Arete, complete genome) position: , mismatch: 10, identity: 0.688

tcatggctggcatccagatctaccaggagcgg	CRISPR spacer
agttcttccgcatccacgtctaccaggagcgg	Protospacer
   *  .. ******* .**************

157. spacer 19.53|3492224|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_023283 (Streptomyces sp. FR1 plasmid pFRL3, complete sequence) position: , mismatch: 10, identity: 0.688

cccgaatacgtgcgcgacctcgtggcactgca	CRISPR spacer
gagggcgccgtgcgcgccctcgtggcacagcg	Protospacer
   *.   ******** *********** **.

158. spacer 19.54|3492285|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK448723 (Streptococcus phage Javan271, complete genome) position: , mismatch: 10, identity: 0.688

cgcagaggaggtggacaatggctgatcgcgtg	CRISPR spacer
cagagaggaggtagataatggctgattatact	Protospacer
*. *********.**.**********.....

159. spacer 19.54|3492285|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MK448746 (Streptococcus phage Javan383, complete genome) position: , mismatch: 10, identity: 0.688

cgcagaggaggtggacaatggctgatcgcgtg	CRISPR spacer
aagagaggaggtagaaaatggctgattatata	Protospacer
 . *********.** **********....*.

160. spacer 19.59|3492591|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_041964 (Pseudomonas phage R18 DNA, complete genome) position: , mismatch: 10, identity: 0.688

ctcaccggcaccatgcgtgagcagtacgaagt	CRISPR spacer
ctcaccaacaccatgcgtgagcacattgcttc	Protospacer
******..***************   .*   .

161. spacer 19.66|3493018|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP007798 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p5, complete sequence) position: , mismatch: 10, identity: 0.688

accccgtggccgatcaagtccagggattccgg	CRISPR spacer
attagtcagccgatcaagtccagcaattccgc	Protospacer
*..   ..*************** .******

162. spacer 19.67|3493079|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR723673 (Rhizobium flavum strain YW14 plasmid 4) position: , mismatch: 10, identity: 0.688

cggcccggcgagctcccaggccacgtgccgta	CRISPR spacer
atatccggcgagctcccaggcctcgcgcgcag	Protospacer
  ..****************** **.**   .

163. spacer 19.67|3493079|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015009 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA04, complete sequence) position: , mismatch: 10, identity: 0.688

cggcccggcgagctcccaggccacgtgccgta	CRISPR spacer
ataaccggcgagctcccaggcctcgcgcgcgg	Protospacer
  . ****************** **.**   .

164. spacer 19.67|3493079|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NC_006362 (Nocardia farcinica IFM 10152 plasmid pNF1, complete sequence) position: , mismatch: 10, identity: 0.688

cggcccggcgagctcccaggccacgtgccgta	CRISPR spacer
gatgccgacgagctccccggccacgtgttcga	Protospacer
 .  ***.********* *********..  *

165. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028228 (Lactobacillus plantarum strain SRCM101187 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.688

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
aaccgctgctttttgcgccacgccctgacgaa	Protospacer
   ***.*************.*****   *.

166. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP035561 (Lactobacillus plantarum strain SRCM103297 plasmid unnamed5) position: , mismatch: 10, identity: 0.688

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
aaccgctgctttttgcgccacgccctgacgaa	Protospacer
   ***.*************.*****   *.

167. spacer 19.68|3493140|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP035158 (Lactobacillus plantarum strain SRCM103362 plasmid unnamed2) position: , mismatch: 10, identity: 0.688

ttgcgccgctttttgcgccatgccctccaggc	CRISPR spacer
aaccgctgctttttgcgccacgccctgacgaa	Protospacer
   ***.*************.*****   *.

168. spacer 19.73|3493445|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP032924 (Agrobacterium tumefaciens strain 1D1108 plasmid pAt1D1108b, complete sequence) position: , mismatch: 10, identity: 0.688

catcatatccgcccagcgtcaaaatcgcttcg	CRISPR spacer
ggcagtcgccgcccagcgtcacaatcgcgtcc	Protospacer
 .. .*  ************* ****** **

169. spacer 10.23|1685753|35|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021119 (Streptomyces sp. CLI2509 strain CLI2905 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.686

tttcgcctagcccgcctcgggtgcctccggggcgt	CRISPR spacer
cgacgcctcgcccgcgtcgggtgcctccccgctcg	Protospacer
.  ***** ****** ************  * .

170. spacer 19.27|3490638|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP049244 (Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.656

tgcttggcgatatggaggcaaagatcgccggt	CRISPR spacer
caggccattatgtgcaggcaaagatcgccggt	Protospacer
..  . .. **.** *****************

171. spacer 19.32|3490943|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP049244 (Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.656

tgcttggcgatatggaggcaaagatcgccggt	CRISPR spacer
caggccattatgtgcaggcaaagatcgccggt	Protospacer
..  . .. **.** *****************

172. spacer 19.40|3491431|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP020716 (Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.656

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
tgacatcgctgccaccacaacctccaccggcg	Protospacer
     *********** ***** *****.  .

173. spacer 19.42|3491553|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP020716 (Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.656

attgttcgctgccaccccaaccgccaccacaa	CRISPR spacer
tgacatcgctgccaccacaacctccaccggcg	Protospacer
     *********** ***** *****.  .

174. spacer 19.54|3492285|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to MN692948 (Marine virus AFVG_117M19, complete genome) position: , mismatch: 11, identity: 0.656

cgcagaggaggtggacaatggctgatcgcgtg	CRISPR spacer
aacagaggaggtgtccaatggctgaatattac	Protospacer
 .***********  ********** ...

175. spacer 19.70|3493262|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045074 (Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.656

ggttggttttgtccccggattcgttccgggac	CRISPR spacer
agttggtattgtcaccggattcgtcaaaaatg	Protospacer
.****** ***** **********.  ...

176. spacer 19.71|3493323|32|NC_008554|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045074 (Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.656

ggttggttttgtccccggattcgttccgggac	CRISPR spacer
agttggtattgtcaccggattcgtcaaaaatg	Protospacer
.****** ***** **********.  ...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

56761 : 121944

Mycobacterium_phage(12.5%)

protease,integrase,tRNA

attL 67220:67235|attR 121033:121048

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041439485.1\|56761_57076_+\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	6.8e-14	48.8
WP_011696919.1\|57076_59407_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	5.1e-162	41.7
WP_011696920.1\|59425_60130_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_150109391.1\|60381_60618_-	hypothetical protein	NA	NA	NA	NA
WP_011696922.1\|61276_62605_+	GTPase	NA	NA	NA	NA
WP_011696923.1\|62716_63652_+	carbamate kinase	NA	NA	NA	NA
WP_011696924.1\|63698_64796_-	hypothetical protein	NA	NA	NA	NA
WP_011696925.1\|64810_65401_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_011696926.1\|66159_66795_-	lytic transglycosylase domain-containing protein	A0A0H3V0Q1	Geobacillus_virus	1.1e-31	60.5
WP_011696927.1\|66964_67630_-	fructose-6-phosphate aldolase	A0A0E3FNR2	Synechococcus_phage	1.1e-48	49.5
67220:67235	attL	NA	NA	NA	NA
WP_011696928.1\|67651_67909_-	TRASH domain-containing protein	NA	NA	NA	NA
WP_011696929.1\|67922_68417_-	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_011696930.1\|68459_69626_-	LL-diaminopimelate aminotransferase	NA	NA	NA	NA
WP_011696931.1\|69889_70693_-	4-hydroxy-tetrahydrodipicolinate reductase	NA	NA	NA	NA
WP_011696932.1\|70726_71602_-	4-hydroxy-tetrahydrodipicolinate synthase	NA	NA	NA	NA
WP_011696933.1\|71612_72476_-	diaminopimelate epimerase	NA	NA	NA	NA
WP_041441224.1\|72651_73926_-	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_011696935.1\|74132_75224_-	hypothetical protein	NA	NA	NA	NA
WP_011696936.1\|75247_76648_-	argininosuccinate lyase	NA	NA	NA	NA
WP_011696937.1\|76677_77883_-	argininosuccinate synthase	NA	NA	NA	NA
WP_011696938.1\|77969_78908_-	ornithine carbamoyltransferase	M1HWF9	Paramecium_bursaria_Chlorella_virus	7.8e-21	30.5
WP_011696939.1\|78904_80095_-	aspartate aminotransferase family protein	A0A1V0SKB7	Klosneuvirus	1.1e-32	29.1
WP_011696940.1\|80164_81061_-	acetylglutamate kinase	NA	NA	NA	NA
WP_011696941.1\|81160_82561_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A2H5BJT2	Erwinia_phage	1.4e-42	29.1
WP_011696942.1\|82566_83106_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_041441228.1\|83197_84109_-	tyrosine recombinase	A0A1I9SC88	Mycobacterium_phage	2.8e-15	30.9
WP_011696944.1\|84697_86773_+	elongation factor G	A0A2K9L2P9	Tupanvirus	2.8e-10	20.8
WP_011696945.1\|86913_88029_+	DUF4388 domain-containing protein	NA	NA	NA	NA
WP_011696946.1\|88039_88579_+	MogA/MoaB family molybdenum cofactor biosynthesis protein	NA	NA	NA	NA
WP_011696947.1\|88846_89242_-	hypothetical protein	NA	NA	NA	NA
WP_011696948.1\|89273_89750_-	hypothetical protein	NA	NA	NA	NA
WP_011696949.1\|89746_90532_-	hypothetical protein	NA	NA	NA	NA
WP_011696950.1\|90603_92307_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_011696951.1\|92496_93741_+	AmmeMemoRadiSam system protein B	NA	NA	NA	NA
WP_011696952.1\|93793_94720_-	EF-P lysine aminoacylase GenX	A0A1V0SFI4	Hokovirus	1.6e-26	27.4
WP_011696953.1\|94724_95297_-	elongation factor P	NA	NA	NA	NA
WP_011696954.1\|95480_96761_+	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	2.9e-143	62.2
WP_011696955.1\|97252_98035_+	(Fe-S)-binding protein	NA	NA	NA	NA
WP_011696956.1\|98053_99481_+	iron-sulfur cluster-binding protein	NA	NA	NA	NA
WP_167321296.1\|99526_100303_+	LUD domain-containing protein	NA	NA	NA	NA
WP_011696959.1\|100768_101329_-	DUF3558 domain-containing protein	NA	NA	NA	NA
WP_011696960.1\|101882_102251_+	RNA-binding protein	NA	NA	NA	NA
WP_041439495.1\|103061_103244_+	hypothetical protein	NA	NA	NA	NA
WP_011696962.1\|104086_105943_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.5e-26	25.7
WP_167321297.1\|106131_107361_+	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_041439498.1\|107498_109031_-	hypothetical protein	Q9HH59	Methanothermobacter_phage	5.5e-16	25.2
WP_011696966.1\|110251_111904_+	tetrathionate reductase family octaheme c-type cytochrome	NA	NA	NA	NA
WP_011696967.1\|111907_112576_+	cytochrome b561	NA	NA	NA	NA
WP_041439501.1\|112748_113945_-	chromate efflux transporter	NA	NA	NA	NA
WP_011696969.1\|114049_114370_-	rhodanese domain-containing protein	NA	NA	NA	NA
WP_041439504.1\|114366_115623_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	5.6e-06	29.6
WP_011696972.1\|116445_116916_+	hypothetical protein	NA	NA	NA	NA
WP_011696973.1\|116912_117332_+	chromate resistance protein	NA	NA	NA	NA
WP_083763879.1\|117514_117745_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011696974.1\|118043_120491_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	3.3e-180	45.0
WP_011696975.1\|120690_121944_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.9e-132	59.4
121033:121048	attR	NA	NA	NA	NA

DBSCAN-SWA_2

2290793 : 2302890

Faecalibacterium_phage(22.22%)

head,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011698727.1\|2290793_2291195_+	hypothetical protein	A0A2I7R6R1	Vibrio_phage	1.6e-15	36.4
WP_011698728.1\|2291279_2291642_+	hypothetical protein	NA	NA	NA	NA
WP_011698729.1\|2291638_2291881_+	hypothetical protein	NA	NA	NA	NA
WP_011698730.1\|2291950_2292547_+	hypothetical protein	NA	NA	NA	NA
WP_150109634.1\|2292647_2294093_+	hypothetical protein	Q6QIC1	Burkholderia_phage	4.0e-165	60.9
WP_011698732.1\|2294149_2295898_+	DUF935 domain-containing protein	A0A2H4JAU9	uncultured_Caudovirales_phage	2.8e-112	50.2
WP_011698733.1\|2295894_2297271_+\|capsid	minor capsid protein	A4JWJ6	Burkholderia_virus	1.4e-47	38.3
WP_011698734.1\|2297371_2297878_+	phage virion morphogenesis protein	A0A2K9VH22	Faecalibacterium_phage	2.3e-11	32.9
WP_011698735.1\|2297930_2299010_+	Mu-like prophage FluMu I protein	A0A2K9VH54	Faecalibacterium_phage	7.0e-42	36.2
WP_011698736.1\|2299021_2299417_+	hypothetical protein	A0A0U5KRP3	unidentified_phage	1.8e-19	44.5
WP_011698737.1\|2299532_2300414_+\|head	head protein	M4SRT6	Rhodobacter_phage	2.7e-76	48.7
WP_011698738.1\|2300571_2300859_+	hypothetical protein	NA	NA	NA	NA
WP_011698739.1\|2300839_2301271_+	DUF1320 domain-containing protein	NA	NA	NA	NA
WP_011698740.1\|2301300_2301741_+	DUF1834 family protein	NA	NA	NA	NA
WP_041440242.1\|2301779_2301971_+	hypothetical protein	NA	NA	NA	NA
WP_011698741.1\|2301957_2302890_+	hypothetical protein	G8CLB2	Synechococcus_phage	3.2e-43	34.8

DBSCAN-SWA_3

4557712 : 4693720

109

Bacillus_phage(16.13%)

portal,capsid,tail,integrase,tRNA,plate,transposase

attL 4560186:4560201|attR 4652001:4652016

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150109573.1\|4557712_4558372_-\|transposase	transposase	S5VTP8	Leptospira_phage	6.2e-25	38.0
WP_150109574.1\|4558589_4559003_-	hypothetical protein	NA	NA	NA	NA
WP_011700532.1\|4559403_4560813_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
4560186:4560201	attL	NA	NA	NA	NA
WP_011700533.1\|4561073_4562228_-	response regulator	NA	NA	NA	NA
WP_083764150.1\|4562690_4566158_+	PAS domain S-box protein	Q8QKV7	Ectocarpus_siliculosus_virus	1.6e-07	22.5
WP_011700536.1\|4566383_4570190_+	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	1.2e-11	22.8
WP_153307224.1\|4571841_4572009_+	hypothetical protein	NA	NA	NA	NA
WP_011700537.1\|4572504_4573995_+\|tRNA	lysine--tRNA ligase	A0A2K9KZX5	Tupanvirus	6.0e-84	39.9
WP_011700538.1\|4574001_4575234_+	lipoprotein-releasing ABC transporter permease subunit	NA	NA	NA	NA
WP_041443211.1\|4575274_4575919_+	ATP-binding cassette domain-containing protein	A0A1M7XV31	Cedratvirus	5.7e-15	30.2
WP_011700540.1\|4576270_4578937_+	outer membrane protein assembly factor BamA	NA	NA	NA	NA
WP_011700541.1\|4578949_4579483_+	OmpH family outer membrane protein	NA	NA	NA	NA
WP_011700542.1\|4579626_4580694_+	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	NA	NA	NA	NA
WP_011700543.1\|4580698_4581142_+	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_011700544.1\|4581194_4581971_+	acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase	NA	NA	NA	NA
WP_083764211.1\|4582871_4583927_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011700546.1\|4583887_4585042_+	lipid-A-disaccharide synthase	NA	NA	NA	NA
WP_011700547.1\|4585038_4586403_+	3-deoxy-D-manno-octulosonic acid transferase	NA	NA	NA	NA
WP_011700548.1\|4586542_4587574_-	U32 family peptidase	NA	NA	NA	NA
WP_011700549.1\|4588073_4589774_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_150109575.1\|4590231_4591608_-\|transposase	IS1380-like element ISSfu1 family transposase	A0A1X9I6F6	Streptococcus_phage	2.1e-38	28.8
WP_011700551.1\|4591678_4592227_-	hypothetical protein	NA	NA	NA	NA
WP_100255602.1\|4592649_4594026_-\|transposase	IS1380 family transposase	A0A1X9I6F6	Streptococcus_phage	2.7e-38	28.6
WP_150109576.1\|4594068_4595757_-	hypothetical protein	NA	NA	NA	NA
WP_167321381.1\|4595768_4599368_-	hypothetical protein	NA	NA	NA	NA
WP_011700554.1\|4599370_4601947_-	hypothetical protein	NA	NA	NA	NA
WP_011700555.1\|4602097_4603996_-	GNAT family N-acetyltransferase	A0A2H4P6Z4	Pseudomonas_phage	3.4e-23	33.5
WP_011700556.1\|4604254_4605343_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_049766435.1\|4605403_4606015_-	LysM peptidoglycan-binding domain-containing protein	A0A142F1N7	Bacillus_phage	2.7e-06	31.6
WP_011700558.1\|4606427_4607819_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_011700559.1\|4608329_4609343_+	3-deoxy-7-phosphoheptulonate synthase	NA	NA	NA	NA
WP_049766436.1\|4609396_4610305_+	prephenate dehydrogenase/arogenate dehydrogenase family protein	NA	NA	NA	NA
WP_011700561.1\|4610323_4610857_-	metal-dependent transcriptional regulator	NA	NA	NA	NA
WP_011700563.1\|4612888_4613344_+	bifunctional nuclease family protein	NA	NA	NA	NA
WP_011700564.1\|4613749_4614919_+	recombination-associated protein RdgC	NA	NA	NA	NA
WP_011700565.1\|4614940_4615993_+	hypothetical protein	NA	NA	NA	NA
WP_011700566.1\|4616081_4618295_-	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.7e-138	40.3
WP_011700567.1\|4618478_4622183_-	hypothetical protein	NA	NA	NA	NA
WP_011700568.1\|4623766_4624189_-	hypothetical protein	K4HZX2	Acidithiobacillus_phage	3.9e-12	36.9
WP_011700569.1\|4624185_4625772_-	recombinase family protein	K4ICM1	Acidithiobacillus_phage	1.7e-97	39.8
WP_011700570.1\|4625764_4626289_-	DUF2924 domain-containing protein	K4I3X1	Acidithiobacillus_phage	2.7e-15	38.2
WP_011700571.1\|4626323_4626566_-	hypothetical protein	NA	NA	NA	NA
WP_011700572.1\|4626868_4627492_+	transcriptional repressor LexA	A0A0N9RTK0	Paenibacillus_phage	3.5e-09	35.4
WP_011700573.1\|4627538_4628705_+	hypothetical protein	NA	NA	NA	NA
WP_011700574.1\|4628697_4629762_+	hypothetical protein	NA	NA	NA	NA
WP_011700575.1\|4630084_4630411_+	hypothetical protein	NA	NA	NA	NA
WP_011700576.1\|4630606_4631191_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_011700577.1\|4631295_4631634_+	hypothetical protein	NA	NA	NA	NA
WP_011700578.1\|4631630_4632647_+	hypothetical protein	NA	NA	NA	NA
WP_011700579.1\|4632673_4633444_+	ATP-binding protein	A0A249XZW4	Enterococcus_phage	1.5e-22	27.0
WP_011367844.1\|4633456_4633930_+	DUF669 domain-containing protein	NA	NA	NA	NA
WP_011367843.1\|4633929_4634412_+	hypothetical protein	NA	NA	NA	NA
WP_041441088.1\|4634363_4636592_+	AAA family ATPase	A0A218KCE8	Bacillus_phage	1.8e-63	30.3
WP_011700581.1\|4636588_4639900_+	DNA primase	NA	NA	NA	NA
WP_011700582.1\|4639993_4641340_+	ATP-binding protein	NA	NA	NA	NA
WP_011700583.1\|4641339_4641936_+	RloB domain-containing protein	NA	NA	NA	NA
WP_011700584.1\|4642427_4643198_+	hypothetical protein	NA	NA	NA	NA
WP_011700586.1\|4643637_4644138_+	hypothetical protein	NA	NA	NA	NA
WP_011700587.1\|4644738_4645653_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	3.3e-16	28.1
WP_011700588.1\|4645633_4646008_-	hypothetical protein	NA	NA	NA	NA
WP_011366959.1\|4646041_4646236_-	hypothetical protein	NA	NA	NA	NA
WP_011367832.1\|4646376_4646649_+	hypothetical protein	NA	NA	NA	NA
WP_011366961.1\|4646645_4646924_+	hypothetical protein	NA	NA	NA	NA
WP_011700589.1\|4646923_4648447_+	hypothetical protein	NA	NA	NA	NA
WP_041441093.1\|4648561_4650070_+\|portal	phage portal protein	NA	NA	NA	NA
WP_011700591.1\|4650069_4654659_+\|capsid	minor capsid protein	NA	NA	NA	NA
4652001:4652016	attR	NA	NA	NA	NA
WP_011700592.1\|4654655_4655168_+	hypothetical protein	NA	NA	NA	NA
WP_011700593.1\|4655164_4655518_+	hypothetical protein	NA	NA	NA	NA
WP_011700594.1\|4655620_4658017_+	DNA methyltransferase	NA	NA	NA	NA
WP_011700595.1\|4658029_4658392_+	hypothetical protein	NA	NA	NA	NA
WP_011700596.1\|4658410_4659274_+	hypothetical protein	NA	NA	NA	NA
WP_011700597.1\|4659292_4659652_+	hypothetical protein	NA	NA	NA	NA
WP_011700598.1\|4659638_4660103_+	hypothetical protein	NA	NA	NA	NA
WP_011700599.1\|4660089_4660449_+	hypothetical protein	NA	NA	NA	NA
WP_011700600.1\|4660438_4660924_+	hypothetical protein	NA	NA	NA	NA
WP_011700601.1\|4660983_4661532_+	hypothetical protein	NA	NA	NA	NA
WP_011700602.1\|4661544_4661802_+	hypothetical protein	NA	NA	NA	NA
WP_011700603.1\|4661804_4663334_+\|tail	tail protein	A0A127AW39	Bacillus_phage	1.4e-75	35.6
WP_011366977.1\|4663349_4663811_+\|tail	phage tail protein	NA	NA	NA	NA
WP_011700604.1\|4663826_4664504_+	hypothetical protein	A0A127AX46	Bacillus_phage	5.8e-10	27.5
WP_011700605.1\|4664647_4668283_+\|tail	phage tail tape measure protein	H7BVM4	unidentified_phage	2.7e-77	40.0
WP_011700606.1\|4668291_4668603_+	hypothetical protein	NA	NA	NA	NA
WP_011366981.1\|4668606_4669077_+	hypothetical protein	NA	NA	NA	NA
WP_011700607.1\|4669073_4669364_+	hypothetical protein	NA	NA	NA	NA
WP_011700608.1\|4669430_4670714_+	phage late control D family protein	NA	NA	NA	NA
WP_011700609.1\|4670706_4671081_+	DUF882 domain-containing protein	I7FWL0	Pectobacterium_phage	5.5e-18	45.0
WP_011700610.1\|4671077_4671497_+	DUF1353 domain-containing protein	A0A2H4JDM4	uncultured_Caudovirales_phage	1.8e-14	43.5
WP_011700611.1\|4671489_4672539_+	hypothetical protein	NA	NA	NA	NA
WP_011700612.1\|4672551_4672926_+	hypothetical protein	NA	NA	NA	NA
WP_011366988.1\|4672922_4673186_+	PAAR domain-containing protein	R9U4D0	Rhizobium_phage	1.9e-09	67.9
WP_011700613.1\|4673196_4673505_+	hypothetical protein	NA	NA	NA	NA
WP_011700614.1\|4673501_4674512_+	hypothetical protein	NA	NA	NA	NA
WP_011700615.1\|4674524_4675415_+	hypothetical protein	NA	NA	NA	NA
WP_011700616.1\|4675414_4676350_+	GPW/gp25 family protein	M4SKQ1	Cyanophage	1.9e-06	37.6
WP_011700617.1\|4676449_4677859_+\|plate	baseplate J protein	A0A1Q1PVP2	Phage_DP-2017a	4.3e-39	25.6
WP_011700618.1\|4677858_4679433_+\|tail	tail protein	NA	NA	NA	NA
WP_011700619.1\|4679443_4680037_+	hypothetical protein	NA	NA	NA	NA
WP_011700620.1\|4680047_4681037_+	hypothetical protein	NA	NA	NA	NA
WP_011700621.1\|4681159_4681621_+	hypothetical protein	NA	NA	NA	NA
WP_011700622.1\|4681633_4682167_+	hypothetical protein	NA	NA	NA	NA
WP_011700623.1\|4682182_4685731_+	DUF4815 domain-containing protein	F8WQ05	Bacillus_phage	4.3e-72	26.0
WP_011700624.1\|4685743_4686001_+	hypothetical protein	NA	NA	NA	NA
WP_011700625.1\|4686249_4687212_+	amidoligase	A0A1B1IUD7	uncultured_Mediterranean_phage	6.2e-106	60.7
WP_011700626.1\|4687223_4687745_+	DUF5049 domain-containing protein	NA	NA	NA	NA
WP_011700627.1\|4687729_4688527_+	glucosamine 6-phosphate synthetase	A0A1B1IUF7	uncultured_Mediterranean_phage	2.5e-52	40.2
WP_011700628.1\|4688523_4689048_+	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_011700629.1\|4689210_4689435_+	helix-turn-helix domain-containing protein	A0A1B1IUF9	uncultured_Mediterranean_phage	3.4e-15	54.0
WP_011700630.1\|4689431_4690547_+	DNA cytosine methyltransferase	A0A0R6PG08	Moraxella_phage	1.9e-111	58.8
WP_011700631.1\|4690543_4693720_+	helicase	A0A1B1IUI1	uncultured_Mediterranean_phage	6.8e-109	30.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_008554

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection