CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP027218	Pseudomonas sp. DTU12.3 chromosome, complete genome	5 crisprs	PD-DExK,DEDDh,csa3,RT,WYL,DinG,cas3	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP027218_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027218_2

3010476-3010568

Orphan

Consensus_repeat	Method
TGTGTCGATTATGGACTTGAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027218_2

>merge|CP027218|2|3010476-3010568|CRISPRCasFinder
TGTGTCGATTATGGACTTGAGAGATTGAGGCCGGCCGAGGTGTGTTACGGGTTACATCGACCTGAAAGATTGTGTCGATTATGGACTTGAGAG

>CP027218|2|2|3010476-3010568|CRISPRCasFinder
TGTGTCGATTATGGACTTGAGAG	ATTGAGGCCGGCCGAGGTGTGTTACGGGTTACATCGACCTGAAAGAT
TGTGTCGATTATGGACTTGAGAG

Protein	Signature genes	Signature genes Name	Protein_function
CP027218.1\|QAX84878.1\|3018270_3019119_+\|sulfonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
CP027218.1\|QAX84862.1\|2988062_2990435_+\|type-II-secretion-system-protein-GspD	unknown	unknown	gnl\|CDD\|274175
CP027218.1\|QAX84871.1\|3010782_3011670_+\|peroxidase	unknown	unknown	gnl\|CDD\|273607
CP027218.1\|QAX84868.1\|3007765_3007960_-\|stability-determinant	unknown	unknown	unknown
CP027218.1\|QAX84861.1\|2987517_2988066_+\|general-secretion-pathway-protein-GspM	unknown	unknown	gnl\|CDD\|377391
CP027218.1\|QAX84875.1\|3015336_3015582_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|224069
CP027218.1\|QAX84874.1\|3013578_3015309_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|181346
CP027218.1\|QAX84865.1\|2993672_2994776_+\|protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|270283
CP027218.1\|QAX84866.1\|2994967_3007444_+\|hemagglutinin	unknown	unknown	gnl\|CDD\|372178
CP027218.1\|QAX84870.1\|3009372_3010470_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378890
CP027218.1\|QAX84879.1\|3019115_3020078_+\|PBS-lyase	unknown	unknown	gnl\|CDD\|224331
CP027218.1\|QAX84873.1\|3012829_3013582_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
CP027218.1\|QAX84872.1\|3011680_3012646_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|223745
CP027218.1\|QAX84864.1\|2991992_2993204_+\|type-II-secretion-system-protein-GspF	unknown	unknown	gnl\|CDD\|273980
CP027218.1\|QAX84876.1\|3015829_3017233_+\|nitrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270277
CP027218.1\|QAX84863.1\|2990586_2991993_+\|type-II-secretion-system-protein-GspE	unknown	unknown	gnl\|CDD\|131585
CP027218.1\|QAX84877.1\|3017488_3018271_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP027218.1\|QAX84880.1\|3020074_3020347_+\|DUF971-domain-containing-protein	unknown	unknown	gnl\|CDD\|377616
CP027218.1\|QAX84867.1\|3007497_3007776_-\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	unknown	unknown	gnl\|CDD\|368240
CP027218.1\|QAX84869.1\|3008214_3009162_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226763

Protein	Function_ID	Function_description	E-value
CP027218.1\|QAX84878.1\|3018270_3019119_+\|sulfonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	1.67389e-122
CP027218.1\|QAX84862.1\|2988062_2990435_+\|type-II-secretion-system-protein-GspD	gnl\|CDD\|274175	TIGR02517, Putative_type_II_secretion_system_protein_D, type II secretion system protein D. In Gram-negative bacteria, proteins that have first crossed the inner member by Sec-dependent protein transport can be exported across the outer membrane by type II secretion, also called the main terminal branch of the general secretion pathway. Members of this family are general secretion pathway protein D. In Yersinia enterocolitica, a second member of this family is part of a novel second type II secretion system specifically associated with virulence (See ). This family is closely homologous to the type IV pilus outer membrane secretin PilQ (TIGR02515) and to the type III secretion system pore YscC/HrcC (TIGR02516). [Protein fate, Protein and peptide secretion and trafficking].	0
CP027218.1\|QAX84871.1\|3010782_3011670_+\|peroxidase	gnl\|CDD\|273607	TIGR01413, Probable_deferrochelatase/peroxidase_EfeN, Dyp-type peroxidase family. A defined member of this superfamily is Dyp, a dye-decolorizing peroxidase that lacks a typical heme-binding region. A distinct, uncharacterized branch (TIGR01412) of this superfamily has a typical twin-arginine dependent signal sequence characteristic of exported proteins with bound redox cofactors.	3.67828e-70
CP027218.1\|QAX84861.1\|2987517_2988066_+\|general-secretion-pathway-protein-GspM	gnl\|CDD\|377391	pfam04612, T2SSM, Type II secretion system (T2SS), protein M. This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers.	8.37936e-20
CP027218.1\|QAX84875.1\|3015336_3015582_+\|ferredoxin-family-protein	gnl\|CDD\|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	1.26655e-10
CP027218.1\|QAX84874.1\|3013578_3015309_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|181346	PRK08275, PRK08275, putative oxidoreductase; Provisional.	0
CP027218.1\|QAX84865.1\|2993672_2994776_+\|protein-disulfide-reductase	gnl\|CDD\|270283	cd13565, PBP2_PstS, Substrate binding domain of ABC-type phosphate transporter, a member of the type 2 periplasmic-binding fold superfamily. This subfamily contians phosphate binding domain found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.49505e-37
CP027218.1\|QAX84866.1\|2994967_3007444_+\|hemagglutinin	gnl\|CDD\|372178	pfam12545, DUF3739, Filamentous haemagglutinin family outer membrane protein. This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam05860.	5.04164e-45
CP027218.1\|QAX84870.1\|3009372_3010470_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	7.28293e-40
CP027218.1\|QAX84879.1\|3019115_3020078_+\|PBS-lyase	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.00789e-26
CP027218.1\|QAX84873.1\|3012829_3013582_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	4.62219e-77
CP027218.1\|QAX84872.1\|3011680_3012646_+\|oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	4.87253e-55
CP027218.1\|QAX84864.1\|2991992_2993204_+\|type-II-secretion-system-protein-GspF	gnl\|CDD\|273980	TIGR02120, Putative_general_secretion_pathway_protein_F, type II secretion system protein F. This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking].	1.6377e-178
CP027218.1\|QAX84876.1\|3015829_3017233_+\|nitrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270277	cd13559, PBP2_SsuA_like_3, Putative substrate binding domain of sulfonate binding protein-like, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.23515e-147
CP027218.1\|QAX84863.1\|2990586_2991993_+\|type-II-secretion-system-protein-GspE	gnl\|CDD\|131585	TIGR02533, Type_II_secretion_system_protein_E, type II secretion system protein E. This family describes GspE, the E protein of the type II secretion system, also called the main terminal branch of the general secretion pathway. This model separates GspE from the PilB protein of type IV pilin biosynthesis. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
CP027218.1\|QAX84877.1\|3017488_3018271_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.91478e-68
CP027218.1\|QAX84880.1\|3020074_3020347_+\|DUF971-domain-containing-protein	gnl\|CDD\|377616	pfam06155, DUF971, Protein of unknown function (DUF971). This family consists of several short bacterial proteins and one sequence from Oryza sativa. The function of this family is unknown.	2.42395e-26
CP027218.1\|QAX84867.1\|3007497_3007776_-\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	4.29236e-11
CP027218.1\|QAX84869.1\|3008214_3009162_-\|hypothetical-protein	gnl\|CDD\|226763	COG4313, COG4313, Protein involved in meta-pathway of phenol degradation [Energy production and conversion].	5.47551e-115

>CP027218.1|QAX84870.1|3009372_3010470_+|AraC-family-transcriptional-regulator
MNVKVQDPTFELALVSPFLLQTLAEVAQNKGIDPESLCRGLGFTLDDLQDPTQRISYRQAVAMIQRALKALPNQGLGLWVGAQNVLGTLGLLGHVLSLCKTLRDAFALGIRHQHTSGGIVVSSVDVVGEQLHLDAECRLPFADVQVFAVEEFFASLLVYGRALAGADFKPIAVEFMHAAPGYLSEYQRLLGPDVRFGCLHNRMLIDVQWLDVNLPNHHALALRQAVALLELEAAQVHQKLDLIQAVERAIARDLSSGSHIEKIAGDLNMSSRTLRRRLTEHALTFEALLEQVRQARTLSLLANPDMPIERITEEVGYSDVRSFRRAFKRWTGLSPSAWRNDANPHPSPLPEGEGADRGVLRVTST
>CP027218.1|QAX84869.1|3008214_3009162_-|hypothetical-protein
MHPNRATFPLRLALCLLGCAATLPALATEAGVDNIGTGTDGFFMLPLEVDSLPENMVAFNLYYNHYKATKLNISSFGGKVPNVEIESTAVIPRLDYLSPVRIFGGRLAGYIAQPWLKQEVSVFGLSDTREGMGDTTIAPIILWDMGKNLTLGAAIEVTVPTGEYSVDRLANTSNNFYTYKPLFSFTWLPTDKTEVSMKTTYSFNEKNKDTDYKSGQIFHFDYSASYKITDDVMLGLNGYYLKQTTDDKQFGHTVQFAGQDVDDGVRGEVFAIGPALHFTFLKYASAEIRWAKEFDVENRPEGEMLWAKVSIPYAF
>CP027218.1|QAX84868.1|3007765_3007960_-|stability-determinant
MSILLSPFYSEFESEEEAESYDRWFRAKVQAALDDPRPGIPHEEAMVRLDQLLEEKRKNRRAAA
>CP027218.1|QAX84867.1|3007497_3007776_-|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family
MPLEWSNQALDDLADIIDYIEQHNSNASAALQRKVGAATQRLSSIPFGYRSGRVPGTREMVVNSNYLLVYRVNGRIKILTLVHTRQQYPRTS
>CP027218.1|QAX84866.1|2994967_3007444_+|hemagglutinin
MLARPSRRSTRAQMLKREVADPALWLLKPLAHAVALCLVAGSAQAQTAFSSNWFAAKGAAQQAAAARPSVGGLPGMTPPLAQQQRANQQLQRSLQTLNNTVAAIAAQQAAQAAGRAVALGSVQSVPDGLGEGGLKVDNSLSQGWLNAKGPQQTQADGKTTVKIEQTADKAILNWETFNVGRNTTVEFAQQSNWAVLNRVNDPSARASQIQGQIKGDGTVMLINRNGIVFSGSSQVNVRNLVAAAANITDIQFRERGLYFDSTATQPTFTDAAGKVLVERGATIQTHAPKASTDAGGYALLLGNEVQNDGNISTPKGQTLLGAGDRFYIRKGSGTDGNAVSTTFGNEVTPGFKTGAVAGKVSNNGLIQAATGDITLTGHEVLQNGVLLASTSVATRGTVHLLNPATDNTGSVTLAQGSVTAIMLDSSDLTALDSQRDASLQAVSAANRIRGDQSRVEIASGGSVEFQNGSITLATGGQVAVSAGRRSLVRDGAVIDVSGAVGVKVAMEANNIKINVQGNEQRDAPVNREGGALNSNDIWVDVRELVYVPAGTNGYATDRWYTAGGLLEVGGYLGTQGHGIGEWMAQGGSVNFAGNDVVTEKGSLINLSGGTLDVQSGAIRQSWLRGADGRLYEVSRAPGDLLYTGLYKGYEDSSERWGQTQFFYNPLIAPSSRQESGYTVGRDAGQLVIATRNALVDGQILGEVFQGERQTQAPRAVLDGYEQSQIARARRAQLIVGQYDPAWSATAGGLQYLLDPLLDQVQIGGTHAAALTAPGLADAVAQERVGKLFLDSDMLNGFQLGALKVSAAKTIVVDQALTVASGGDITLFAPQVQVNASLTARGGSMNVGDVLTGNSALLAPAGTAVGVTVAKGVQLDARGLWSNLRTDPDDVNSLAYLNGGVVSVRSTGSVNLGSGSLLDVSSGGALLANGKTRGGKGGDITLESSPLTRSVSSQLMIDGDVRGYGVTGGGSLTIQSGNVVIGGTGAPHGDNTLQLASSLFSTGFASYSVTGLTGLEVADGAQVDVVMPVYRFGDAAPIQSSGVDPRTALELWTPTLFQENPAKGVLTQRGGASLALQAGSSELALIDPASSPLSIGHGARISVDPGQRIKLRGAGQITVEGELNAWGGTLDIRQQQFGSLDVATKLQNADPQAHNRSIWIGEDAVLDVAGRAYTAVDALGRVYGQIGKGGSIILGGEIDSKKITATSADAYVIVRNGARLDASGTHAVLDVAGGGPTDVATDGGRIALSSYNGVFLDGQLQAAAGGVGASGGRLEIIQDAPLYQMNLASNEVRAPREMIINQGADGALLPAHLQAGEGAAQLRYGQTRLSAERLMSGGFDHLSLLSNGLLTFAGDVDLRMNQSLNLYTGSISLAQAASDTTRINLAAPYMRLSGLGLYAPSDVSMRPRLLANATTELSNARFTATADLLDLSNTLSFGTEGTIAQLAAPAAAVSRRGFDQVTLDSRGDMRFLAPNDNERSSRLWTPGDLNLRAAQIYPATGVSADVRVGYQGYTAVPELARTLRISGHGEAPQALPYSAFGNLLLVAGKIEQGGVIRAPLGLIRLGENSLGKTQELRLLPGSVTSVSGAGLVMPYGGTTDGIDYRYDGKSVVLHGISSALDGVILTGQYVDVQGGALIDLSGGGDLRGAGFVSGRGGSTDARFNPLVRNAADGTFSLPGLSSNPVYAIVPGNQSAFAPALAEAGASDPRIGQQITVGAGVPGLAAGTYTLLPSTFALLPGAFRVEVNGQATPGVTSSALKMRNGSWSSAGLMSIANSGVRDSLPSQVILTSADVLRRYSQYNETSFTQFIESDAARRGVPRALAPMDAKSLNVQLVAGGKHDIDMNFQGQALFAPSKGGVAGSAVVLAQDLEVLGEGRSRTPGFTGISLYADSLDRLEAGRLSLGATPTVEYGSAGNFIRFDGSAANITLREGAVLSAPEVLLRTDKVNGGITLEAGAGINTLGRGDAPYDSTDGFIYQPGSASLLVVSNGWTSTLAPTVATYSEGAGSIRIGTCVAQPCAQPTLLYSNGSITAATDNQFELNESVRFGTRHLALAVGAVNAGSAEALAAAGRVPSGLTLNQNVLDRLLRGDTQFGAPALETLSLTTRDSFNFFGNVSLDTLDPQTGVSRLQNLLLATPAVYGWGEAGDVATIRTANLIWNGATQAPGAVASGGAGTGRGTLDIQAQRIEFGYGPNPQPNGLDQNNRLALGFANVNLNASERITANHKGSLAVYLAQGAYDPISGYVYSGGNLNLRTPLLTGEAASVNLLKAGDDLTVSGVANAAVADALGAELTLEGRNVLLDGRIALASGKLVVKSENNLTLTNAAHLDLAGRTLPFNDVSKYSWGGDVALYSSHGNIRQAAGSRIDLSAHNNQAGNLSAVALAADAGVVDLQGEILGASSGYYDAGGTLVPYKAGGVDIRAQRLGNDLNQDFAALNQRLNAGRVFGSRSFQLKQGSLVIGDGLKAGEVNVSVDNGSLTVAGLIDASGERVGSIRLSANNGLTLTGNAVLDAHGRVLRVDSYGKIIDAPNRAMVELDSGNGLLTLAPGARIDLRHGTDAPPGSGAGHNDGLPRGTLELNAPRIGGGDIAIDASGVLNIQGARSIGLNAMRRYTDAADGTDAAVSGRPYQVIDQAYLDVIHGDSTAFIDAALGNGDLLQRKLAGLNNAAYSDAFHLRPGVEIASKTADGDLVVQGDLDLSAYRYASLNPHTQKTAVYGSGESGSLLIRAGGNLDIYGSVNDGFAPPPETVDDAGWKLVPGIQPFGGDLIVPGAGVTLAEGTSFPVGTTLNYDLPIQSATLASGTLLPTQGILAGPYTLTAGTVLAGAVHDAAGNLLYAAGTLLSDNVTLPAGSRLGAGTRLNAATDMQAMLWPKGVPLPGTFADNKIVGVKLSGALALLRGSLIPSMTDVVLADGTAFIDLRPLNGTQQGRNWALASMLPSGSTSWSMRVVAGADLDAADSRTVKPLTSEGHLRLADTHYGVVVTTKKLDTVWAENNGLGYTPGEVVKDDEMFRCDANPGACVAPAKFLWTDGNPMGAPAGSPVSEDDLFWCDIDPAYCAANVGGTTVSTHSQMFSVLRTGAADLDVMAAGNLSMESPFGVYTAGTQSGDVDARYNQPRGRLSDDGSVLGSAGSDNEKWVDGGSDSLYQAWYPQLGGNLTIGAGGSVSGDVVGRRATSITMETREQVPSVAVGNWLWRQGTGNDEIPTAWWINFGSYASQPLADSSRSTAPYLVGFTGFGTLGGGNISLRAGADGGMLDPVGDGRSNLYPRGQGLIVAVGSTGRVGSDGSLQLTGGGDIDMRLGGSLNPSLQARAGETGTQAPRHDLQGAVINLRGAAQISASAVGGVNLHYGAFSLDQDSREVRAYDPFKSTLGSASGGLVLIPGDSGMRLSTRGDLVLGGAADPGRVRLQNSTAFTDASGVGHAGGGLTSFSLWTDHTAIDLFSAGGNLTPSTQLAESDNLSVSTSNTSPTDGRFVYPSILRAVAAKGSIYAGSSAAYGTGNVPPAEGYSLLLAPSTSGQLELLAGDSIYAGGYAINQSGASPAAITSPFAPSFNGFVSNSADRPLMTNNSVDGVATQRNARYPLFAFGADSYSGLSGVQGPARFYALTGDLVGVRSGETLTFFRSGVQQRTWYEAAGPVWMLAGRDLVASGTYLGQPTAVPNEVLSYNGDEIRSTGNLFIHNRPNDVSRVAAGRDILYSSFDIAGPGVLDVSAGRNILMKDRASITSIGPVLAGDSRPGASVVLQAGVGAQGLDYSRFIARYLNPQNLADSQVSLNGQPGKVVKTYLDELQSWLTLGYGFSGNAEQAQAFYAALPSAEQAIFARQVYFAELRAGGLEYNDVDGPRQGSYLRGRNAIAALFPTSDVAGNAIRYDGDITMYGGAGVKTLFGGDIQMLTPGGGQVFGIEGAAPPSTAGIITQGSGNIQLYSQGSILLGQSRIMTTFGGSILGWSAEGDINAGRGSKTTVVYTPPKRVYDTWGNVTLSPSVPSTGAGIATLNPIAEVAPGDIDLIAPLGTIDAGEAGIRVSGNVNIAALTVVNAANISVQGKATGVPVVSAVNTGAITSASSAASSATQAAEDVARQQQAASRQNQASVFTVQVLSFGNEQLAPSRDGASRTQAPGYNPNSPVQVLGAGALDEQAKQQLTEEERGQLKL
>CP027218.1|QAX84865.1|2993672_2994776_+|protein-disulfide-reductase
MFKRTLIAASLTVAALASAQAMAVTGGGASLPAALYKGSANSILPANFSYAVTGSGIGKSAFLTNTAAQFSTTGTVHFAASDSILSASEISTYNTSFGASFGPLIQLPSVATSVAIPYKKAGNTTLNLTSAQLCDALSGTKTTWGALLGTSDTTAIRVVYRTASSGTTEILSRHLNSICPTQFAVNTTFTNARLPAGSAVPSNWVGVANTADVAPAVNAVDGSIGYVGPDGVNAASNAVVARINGVQPTSANVNTALASAPLPTNAANPAQWSPVVANPSSGYAMAAYTNFIFGQCYKDAAVAADVKAFLTQHYSTPGNAVATAAHGFIPVPTNWKTAVTANFVTNSTGNNLDINNASVCNAVGRPL
>CP027218.1|QAX84864.1|2991992_2993204_+|type-II-secretion-system-protein-GspF
MNRYRFEAADATGKIESGHLEADSQSAAFNALRGRGLTALSMHKESNVASHGGGGLFSAKLSDNDLAWATRQLASLLGASLPLEAALSATVEQAEKKHIAHTLSAVRADVRSGMRLAESLAARPRDFPEIYRALIAAGEESGDLAQVMERLADYIEERNNLRGKILTAFIYPGVVGLVSIGIVIFLLSYVVPQVVSAFSQARQDLPGLTLAMLNASDFIRSWGWLCAGIIAAAFWSWRLYLRNPAARLSWHHRVLKLPLFGRFILGLNTARFASTLAILGGAGVPLLRALEAARQTLSNDRLSLSVSDATAKVREGVNLAAALRVENVFPPVLIHLIASGEKTGSLPPMLERAAQTLSRDIERRAMGMTALLEPLMIVVMGGVVLVIVMAVLLPIIEINQLVQ
>CP027218.1|QAX84863.1|2990586_2991993_+|type-II-secretion-system-protein-GspE
MSSLPYAWAKAQRILLCDGVLTVCPSTPGWSISEARRQFGATTIQRVRDDELDGLLAAAYADTGSAAAVVGAAENEVDLDRLMQDMPEITDLLDTQDGAPVIRMINALLTQAARDEASDIHIEPFETHSVVRYRVDGTLRDVVSPRKALHGALVSRIKIMAQLDIAEKRLPQDGRIALRVAGRPIDIRVSTVPTGHGERVVMRLLDKQAGRLHLETLGMDAQVLAKLDHLIRQPHGIVLVTGPTGSGKTTSLYAALARLDASTSNILTVEDPVEYDLPGISQIQVNAKIDMTFALALRAILRQDPDIIMIGEIRDLETAQIAVQASLTGHLVLATLHTNDAVSAVNRLIDMGVEPFLLASSMLGVLAQRLVRRLCNQCKQQDPATPGTWRPVGCAACNQTGYSGRTGIHELFCIDDDIRTLIHQGAGEQALRASAAKAGMFSLREDGERWIRSGATAPEEILRVTRDA
>CP027218.1|QAX84862.1|2988062_2990435_+|type-II-secretion-system-protein-GspD
MKGSGSKPARLALPMLLMALSACSNTNAPQHPAPLLVDSELGRPLANTQRSGDAVADRERAQAQARPVPKQLHNISKTARTGAVAPSSPVASNPLGNQPVTLNFVDADIQAVVRSLSRSSGQQFLVDPRVKGTLTLVSEGQIPANQAYDMLLASLRMQGFSVVDVGGVAHVVPEADAKLLGGPVYSPGKPAGNGMLTRTFRLQYENAVNLIPVLRPIVSPNNPINAYPGNNTIVVTDYAENLNRVAQLIASIDTQSAIDTDVVQIQNGIAADIAPMVAELLDAPGNDPTQKIAVIGDPRSNTIIIRSGSPERTELARNLIYKLDNAQSNPSNLHVVYLRNAQAAKLAQALRGLLTGESDSGSSDSARSVLSAMGSNSNSNGQSGQTGSQTSSGTTSTTNSGSTGGSYAQGSSGSTGSGSGGAQNSEQNVAFSAGGVTIQADATTNTLLISAPEPVYRNLREVIDLLDQRRAQVVIESLIVEVGEDDASEFGVQWQTGNLGGNGVIGGANLGGSGINLNGKTSIDVLPQGLNLGYVNGTVDIPGIGKILDLKVLARALKSKGGTNVLSTPNLLTLDNEAASIFVGQTIPFVSGSYVTGGGGTSNNPFQTVTREEVGLKLNVRPQISEGGTVKLDIYQEVSSIDERASNSAASAGIVTNKRAIDTSILLDDGQIMVLGGLLQDGYSQSNDAVPWLSSIPGIGALFRNERRAITKTNLMVFLRPYIIRDSEAGRSITLNRYDFMRRAQSGLQPERSWAMPDMQAPQLPTAAQGVPAVVPSSGPRATIKAVPIQ
>CP027218.1|QAX84861.1|2987517_2988066_+|general-secretion-pathway-protein-GspM
MNKASLAVYRARWQRFNAQLQARWQPLALREKRMVAGMAIALLSLLVWVALIQPPLKKIAYWQTESPKLRAQTEALEVLLRDVVVRPDGQGVGASLEQTLQASGLGGHYQLQAADGGAWQLSFDAAPANALLDWLLSQPSQLSLQVVEARLQRADNASTEVTAGTLSGTVRMDQALGAKEAS
>CP027218.1|QAX84871.1|3010782_3011670_+|peroxidase
MSYYQPGILATPVPAQARHLFFALESVEALPQAIDNLMNQVDGKSAVVGFGESLAKALDVQIDGLRGFPALTGVGVENPSTQHALWVWLHGVDRGELLNRCNAIEAALAPALRLVEMQEAFRHKDGHDLTGYEDGTENPHDEAAIAAALQSAGTDGMVGGSFAAIQQWQHDLKGFHKLSADDKDNIMGRRLSDNEEIDDAPVSAHVKRTAQESFAPEAFVVRRSMPWIEGDRAGLMFLAFGFSLDAFEAQLRRMSGLEDGITDSLYRISRPITGGYYWCPPLKNGHLDLRALRIG
>CP027218.1|QAX84872.1|3011680_3012646_+|oxidoreductase
MDVVRWGMIGCGSVAERKSGPAFYKAPGSALVAVMGRRLEAVSDYALRHGIDRVYTDVDALINDPEVDAVYIATPPDSHHAYSLKVAAAGKHCCVEKPMALNAGQSREMQQAFAEAGLHLFVSYYRRSLPRFAQVRQWLEEGRIGEVRHLSWTLTKAPSATDVDGRDNWRTDPAVAGGGYFADLASHGFDLFQYLLGDIVEVAGFTARQAGLYAAEDAVSASWRFASGALGMGCWSFVADRREDRVEIIGSLGRISFSVFDEHPVQLHADEIISLEIPHHEHIQWHHVLGMNAHIRGDSQHPAVAEQALKTDWVMDQILKR
>CP027218.1|QAX84873.1|3012829_3013582_+|GntR-family-transcriptional-regulator
MTDNVLSLSSVPLHTQLRDVLRARILDGEYPQDSQMPSESELGALFKVSRITVRQALGDLQKEGLIFKIHGKGTFVAKPKTFQNVSSLQGLAESMTGRGYEVINRLRSFKFIPADKRVAERLQVAEGETVTQIKRVRLINREPISLEITYLPKAVGERLEKADLVTRDIFLILENDCGIALGHADLAIDAVLADSDLTQALNVEAGSPIMRIERLTHDAQGQPLDFEHLYYRGDAFQYRLRIDRQKGEQA
>CP027218.1|QAX84874.1|3013578_3015309_+|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MTRNVLEQEYDIVVIGGGTAGPMAAIKAKEKNRDLRVLLVDKANVKRSGAISMGMDGLNNAIIPGHSTPEQYTKEITIANDGIVNQAAVYAYATHSFETIEQLDRWGVKFEKDETGDYAVKKVHHMGAYVLPMPEGHDIKKVLYRQLKRARVSITNRLVCTRLLTDEEGTVNGVMGFDCRTADFHVIKAKAVILACGAAGRLGLPSSGYLMGTYENPTNAGDGYAMAYHAGAELANLECFQINPLIKDYNGPACAYVTGPLGGYTANNKGERFIECDYWSGQMMWEFHQELESGNGPVFLKLDHLAEETIQNIEEILHSNERPSRGQFHANRGTDYRTQMVEMHISEIGFCSGHSASGVWVNERAETSVKGLYSAGDMAAVPHNYMLGAFTYGWFAGHNAADFVAGREFSALDAEQIEKEKARVYAPLDREHGLPPAQVEYKLRRFVNDYLQPPKVTKKMQIGLQRFSDIERDLEQMKANNAHELMRAMETSVIRDCAEMAARASLFRAESRWGLYHYRVDHPQRNDSEWFCHCHLKKGDDGQMTSFKKAVEPYIIPLDAEEMQAYDRLRVGACAA
>CP027218.1|QAX84875.1|3015336_3015582_+|ferredoxin-family-protein
MAYQAQEIFFRSNAPVTVDEDKCIAEKGCTVCVDVCPMDLLAINPATQKAYMAFDECWYCMPCEKDCPTGAVKVDIPYLLR
>CP027218.1|QAX84876.1|3015829_3017233_+|nitrate-ABC-transporter-substrate-binding-protein
MLRAAIAGLVLASFTLSASAETIRIAIGTQDTTINCAAGGLLIRELGLLDKYLPHDGAYKDAQYDVQWKNFTSGAPLTNEMVAGKLDFGAMADFPGAFNGVAFETAGKHSLFISVLSGSIKGSGNGIVVPSASGVQSLSELKGKTISVPFASTAHGMLLRAVAAQGWDPLKDVNIIAQPPEVAGSALQAGKIDAHADFVPFAELFPSRGFARKIYDGAQANAPTFHGALVDQAYAKKYPEIVVAYLRASIEANQLLAAEPEKYSELIAKVTGVDAEVNYLFHGPLGVQTRDLSWKPEYRQAVGTAIDTLKLLKKADRGLDLNTFIDDQYIRAAFKASNLDYTAQLANYAQTPLKATDSATGKAITDFSHVAEIWVRGEDKVRQYASAEAAFTALAALKQQGKNVRAVYTQASDSGIKLLAEQAWFASDAKGRLSAFLLKGQAQQYASAQGGKVFDFSDATTQAVAAR
>CP027218.1|QAX84877.1|3017488_3018271_+|ABC-transporter-permease
MKTPTLRWTSRAASLLLCLLFWQLAASHHWNLGLVTFANVPTPIAVIEAALGLGDSGKLLQHLTASLSRVFAGYLAALLIGIALGLAIGRSKWAEDLLLPPLEVLRPIPAVAWIPLAILMFPSSELSMVFITFTGALFPILLNTVHGVEGVDPRLIASAKSLGAGRRAILLEVILPGAAPSIITGLAIGMGTSWFCLVTAEMISGQFGIGYYTWESYTIQNYADIVVGMLLIGVLGMGSSLLIKRLGGLFTPWHRPRGKA
>CP027218.1|QAX84878.1|3018270_3019119_+|sulfonate-ABC-transporter-ATP-binding-protein
MSVMQTPEGRIDIRQLSIVLGAGPEAFEAVQGLDCQIEPGQFVCILGPSGCGKSTLLGALAGHLHAHAGSLKVDGGEVSGPSPQRGMVFQHHTLFPWRTVRDNVAFGLKMRGIGKTERHRAADDILKLVGLEGFAERWPDQLSGGMQQRVEIARVLVNRPRLLLMDEPFGALDALTRLNMQELLLDIWTRIRTTVVFVTHDIDEALFLADRLLVMSARPGRIIEDLRLDFARPRTSELVTSAEFSRLKRHCLDLLRHDNDRPLPRLNPLGLPPENPLPRFAL
>CP027218.1|QAX84879.1|3019115_3020078_+|PBS-lyase
MTSIFAVTDNEDIIALQPRLTAEDAGVRRIALIDLADLEEPDGLLWLVDRLGEDPAEEVRAEAARLLEAWEDEEVVQALCVALTDPAPAVQSAAAQSLSLLKTAAAGRVILPWTAHVDVSVRIAAFRALRELRFVDAAPSAVSALNDADASVRREAVGVLGWLKQLDALPALARLASDDPDTEVRRAATGALGLASSAEVLPALRQALQDHAWQVREEAATTLGKVGHIDAGPALVEALSDDYWQVRLRATRSLGRLRFAPALDALIETLGHRISNLRKEAALALGELNDRGAVAALQAAQDDGDPEVRKAVRIALSQLQ
>CP027218.1|QAX84880.1|3020074_3020347_+|DUF971-domain-containing-protein
MNPLSVGNSQSEQILRLSWPDGREQQLNHAELRRQCPCSQCRAFRLKGLTPLVDERVRLIELNPQGYGVQLIFSDGHQRGIYPWPYLANL

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Crispr_ID: CP027218_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027218_3

3870365-3870479

Orphan

Consensus_repeat	Method
TCAGTCCCCTCTCCCCCCGGGAGAGGGTTAGGGTGAGGGG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP027218_3

>merge|CP027218|3|3870365-3870479|CRISPRCasFinder
TCAGTCCCCTCTCCCCCCGGGAGAGGGTTAGGGTGAGGGGGCTTCAGGTCGGTGTAGCTCGAAGAAACAACTCGGTCAGTCCCCTCTCCCTCCGGGAGAGGGTTAGGGTGAGGGG

>CP027218|3|3|3870365-3870479|CRISPRCasFinder
TCAGTCCCCTCTCCCCCCGGGAGAGGGTTAGGGTGAGGGG	GCTTCAGGTCGGTGTAGCTCGAAGAAACAACTCGG
TCAGTCCCCTCTCCCTCCGGGAGAGGGTTAGGGTGAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
CP027218.1\|QAX85533.1\|3877964_3878759_+\|enoyl-ACP-reductase	unknown	unknown	gnl\|CDD\|223696
CP027218.1\|QAX85526.1\|3867017_3867776_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
CP027218.1\|QAX85537.1\|3882847_3883303_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
CP027218.1\|QAX85522.1\|3861826_3864082_-\|lysine-decarboxylase	unknown	unknown	gnl\|CDD\|185297
CP027218.1\|QAX85523.1\|3864452_3865424_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
CP027218.1\|QAX85534.1\|3879056_3880022_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
CP027218.1\|QAX85528.1\|3870563_3872396_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173862
CP027218.1\|QAX85529.1\|3872392_3874234_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173862
CP027218.1\|QAX85530.1\|3874238_3875312_+\|microcin-C-ABC-transporter-permease-YejB	unknown	unknown	gnl\|CDD\|226642
CP027218.1\|QAX85520.1\|3860338_3861232_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176107
CP027218.1\|QAX85525.1\|3866455_3866926_-\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|178927
CP027218.1\|QAX85532.1\|3876334_3877945_+\|microcin-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226641
CP027218.1\|QAX87738.1\|3860022_3860253_+\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX87739.1\|3867842_3868610_+\|hydroxyacylglutathione-hydrolase	unknown	unknown	gnl\|CDD\|274569
CP027218.1\|QAX85535.1\|3880085_3880664_-\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX85527.1\|3868709_3870173_+\|lytic-transglycosylase	unknown	unknown	gnl\|CDD\|182727
CP027218.1\|QAX85524.1\|3865495_3866254_-\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235574
CP027218.1\|QAX85536.1\|3880665_3882828_-\|twin-arginine-translocation-pathway-signal-protein	unknown	unknown	gnl\|CDD\|224446
CP027218.1\|QAX85531.1\|3875313_3876333_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226690
CP027218.1\|QAX85521.1\|3861197_3861812_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
CP027218.1\|QAX85533.1\|3877964_3878759_+\|enoyl-ACP-reductase	gnl\|CDD\|223696	COG0623, FabI, Enoyl-[acyl-carrier-protein].	2.0814e-148
CP027218.1\|QAX85526.1\|3867017_3867776_-\|SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.19177e-05
CP027218.1\|QAX85537.1\|3882847_3883303_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	7.57884e-79
CP027218.1\|QAX85522.1\|3861826_3864082_-\|lysine-decarboxylase	gnl\|CDD\|185297	PRK15399, PRK15399, lysine decarboxylase.	0
CP027218.1\|QAX85523.1\|3864452_3865424_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	6.47144e-29
CP027218.1\|QAX85534.1\|3879056_3880022_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.69501e-43
CP027218.1\|QAX85528.1\|3870563_3872396_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173862	cd08497, PBP2_NikA_DppA_OppA_like_14, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
CP027218.1\|QAX85529.1\|3872392_3874234_+\|hypothetical-protein	gnl\|CDD\|173862	cd08497, PBP2_NikA_DppA_OppA_like_14, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
CP027218.1\|QAX85530.1\|3874238_3875312_+\|microcin-C-ABC-transporter-permease-YejB	gnl\|CDD\|226642	COG4174, COG4174, ABC-type uncharacterized transport system, permease component [General function prediction only].	0
CP027218.1\|QAX85520.1\|3860338_3861232_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176107	cd08415, PBP2_LysR_opines_like, The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate-domain of LysR-type transcriptional regulators, OccR and NocR, involved in the catabolism of opines and that of LysR for lysine biosynthesis which clustered together in phylogenetic trees. Opines, such as octopine and nopaline, are low molecular weight compounds found in plant crown gall tumors that are produced by the parasitic bacterium Agrobacterium. There are at least 30 different opines identified so far. Opines are utilized by tumor-colonizing bacteria as a source of carbon, nitrogen, and energy. NocR and OccR belong to the family of LysR-type transcriptional regulators that positively regulates the catabolism of nopaline and octopine, respectively. Both nopaline and octopalin are arginine derivatives. In Agrobacterium tumefaciens, NocR regulates expression of the divergently transcribed nocB and nocR genes of the nopaline catabolism (noc) region. OccR protein activates the occQ operon of the Ti plasmid in response to octopine. This operon encodes proteins required for the uptake and catabolism of octopine. The occ operon also encodes the TraR protein, which is a quorum-sensing transcriptional regulator of the Ti plasmid tra regulon. LysR is the transcriptional activator of lysA gene encoding diaminopimelate decarboxylase, an enzyme that catalyses the decarboxylation of diaminopimelate to produce lysine. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.37594e-30
CP027218.1\|QAX85525.1\|3866455_3866926_-\|ribonuclease-HI	gnl\|CDD\|178927	PRK00203, rnhA, ribonuclease H; Reviewed.	8.10189e-98
CP027218.1\|QAX85532.1\|3876334_3877945_+\|microcin-ABC-transporter-ATP-binding-protein	gnl\|CDD\|226641	COG4172, COG4172, ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only].	0
CP027218.1\|QAX87739.1\|3867842_3868610_+\|hydroxyacylglutathione-hydrolase	gnl\|CDD\|274569	TIGR03413, GSH_gloB, hydroxyacylglutathione hydrolase. Members of this protein family are hydroxyacylglutathione hydrolase, a detoxification enzyme known as glyoxalase II. It follows lactoylglutathione lyase, or glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family (pfam00753). [Cellular processes, Detoxification].	4.1585e-144
CP027218.1\|QAX85527.1\|3868709_3870173_+\|lytic-transglycosylase	gnl\|CDD\|182727	PRK10783, mltD, membrane-bound lytic murein transglycosylase D; Provisional.	2.68109e-125
CP027218.1\|QAX85524.1\|3865495_3866254_-\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|235574	PRK05711, PRK05711, DNA polymerase III subunit epsilon; Provisional.	1.16849e-151
CP027218.1\|QAX85536.1\|3880665_3882828_-\|twin-arginine-translocation-pathway-signal-protein	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	2.51915e-125
CP027218.1\|QAX85531.1\|3875313_3876333_+\|ABC-transporter-permease	gnl\|CDD\|226690	COG4239, COG4239, ABC-type uncharacterized transport system, permease component [General function prediction only].	0
CP027218.1\|QAX85521.1\|3861197_3861812_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.51748e-18

>CP027218.1|QAX85527.1|3868709_3870173_+|lytic-transglycosylase
MSSSIRKSVNSDALTRLAQAIAVAVSATLAGCSSHAPQTEATHTPNIAARAKQKPIWLSEKPTPQVPQDIWERMRQGFQLQEGLGVNPRIEQQRLWFASNPSFLENAGERGSLYIHYIVERLEERNMPLELALLPVIESAYNPMAYSRADAVGLWQFIPSTGRYFNLRQTRFYDGRRDITASTTAAMDYLTRLHDMFNGDWLLALAAYNAGEGTVSRAIERNEKLGLPTDYWNLPLPAETQAYVPKLLALSQVVLAPEAYGVNLSPIANEPYFQVVEINQRMDLSKVAAVANIDEDELFQLNPAFKQRTTIDGPQHLLVPTSKAQLLTASLQTMRPEELISPRSLKPVFEGSDPSEVAQLKRAYRVKRGDNLGSIAKANKVEVKDLQRWNKLTGKNLKVGQTLVMQDATKRSPARKSGRVNTVIASNSKTKSKDDSAQQTQYKVKRGDTLYVVAKRFNVEMQHLKRWNPGAGKALKPGQMLTVYQPH
>CP027218.1|QAX87739.1|3867842_3868610_+|hydroxyacylglutathione-hydrolase
MIQISALPAFTDNYIWLLQDHRTQRCAVVDPGDAAPVMAWLVAHPGWVLSDILITHHHHDHVGGVERLKALSGAKVYGPASESIPARDVALKDNDSVSVLGWDFDVYAVPGHTLGHIAYYHHGLLFCGDTLFAAGCGRLFEGTPEQMHHSLSRLAALPEDTLVYCTHEYTLSNLKFAAAVEPTNPDIAARLEKVTQQRQNGVMTLPSTLALEKLTNPFLRTGETLVTQKVDERAGAQNRAPSEVFAALRAWKDKF
>CP027218.1|QAX85526.1|3867017_3867776_-|SAM-dependent-methyltransferase
MTDKAFAQADPDWLALISAAREWLSGPLGQFLLDEERRMLDDELGRFFGGYLVHYGPSAETPPSAPQVQRNVRLGAPLPGVEIVCEEQAWPLSEHAADVVVMQHGLDFCLSPHGLLREAASSVRPGGHLLIIGINPWSTWGLRHVFAHDALRQARCISPSRVADWLNLLGFALEKRRFGCYRPPLASPKWQARLAGWERKAGDWQLSGGGFYLLVARKIVVGLRPLRQERREPMGKLIPLPMAKVNRRRIEP
>CP027218.1|QAX85525.1|3866455_3866926_-|ribonuclease-HI
MSESVESVDTVELFTDGACKGNPGPGGWGALLVCKGVEKELWGGEANTTNNRMELLGAIRGLEALKRPCEVLLVTDSQYVMKGINEWMVNWKKRGWKTAAKEPVKNADLWKELDEQVNRHKVKWKWVRGHIGHHGNERADQLANRGVDDVRGYKQT
>CP027218.1|QAX85524.1|3865495_3866254_-|DNA-polymerase-III-subunit-epsilon
MATRSVVLDTETTGMPVTDGHRIIEIGCVELIGRRLTGRHFHVYLQPDRESDEGAIGVHGITNEFLVGKPRFNEVADEFFEFIKGAQLIIHNAAFDVGFINNEFALMGQKDRADITQHCSILDTLMMARERHPGQRNSLDALCKRYGVDNSGRELHGALLDSEILADVYLTMTGGQTSLSLAGNASDGNGSGEGADNSATEIRRLPADRQPARIIRATEDELAAHLVRLEIIAKSAGGPAMWTQIAEADAQG
>CP027218.1|QAX85523.1|3864452_3865424_+|IS110-family-transposase
MSNFIGIDVAKNTFDIATHLPNGKHKTKAKLTNDPKGFKEFEAWLSKQVEPSSLIVMEATSVYHLELAEFVYNKGYRVCVVNPATTNAYAGSELRRIKTDKSDAKLIADFAREKAEKLPLWAPEPLKYRQLKAMVRRLDDLQEMEQMELNRLDVSDEKVKDSINSVLRHIEKEIVETHKAIKKHIDDDPDMRQMRDLIVTIDGIGQKTLERLLAELGDLRKYDDPRKLVAAAGLNPKLQDSGLLKGRTVISKIGSARVRAGLYMPGLVALKHNKAIIAMKDRLKANGKAPKQIICAAMRKLLHFVHAVLKSGQPFDPEFGLAR
>CP027218.1|QAX85522.1|3861826_3864082_-|lysine-decarboxylase
MYKDLKFPVLIVHRDIKADTVAGDRIRGIARELEQEGFSIVSATDYAEGRLVASTHHGLACMLIAAEDASTNSHLLQNMAELIGLARVRAPELPIFALGEQVTLENAPADAMAELNQLRGILYLFEDTVPFLARQVARAARKYLDGLLPPFFKALVQHTADSNYSWHTPGHGGGVAYHKSPVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTSTANKIVWHSMVARDDLVLVDRNCHKSVLHAIIMTGAIPLYLCPERNELGIIGPIPLSEFSRESIQAKIDASPLTKGRAPKVKLAVVTNSTYDGLCYNAELIKQSLGNSVEVLHFDEAWYAYAAFHEFFAGRYGMATSRSEDSPLVFTTHSTHKLLAAFSQASMIHVQDGGARQLDRDRFNEAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQETFDEALSFRRALANLRQHIAADDWWFSIWQPPGVEGIDRVQTEDWLLKPEADWHGFGEVSDDYVLLDPIKVTLVMPGLNAGGALSEKGIPAAVVSKFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDANVRLDSCLPCVAQEDAGRYRGMGLRDLCDQLHACYRSNATAKHLKRMYTVLPEIAMKPAHAYDHLVRGEVEAVPIDALEGRIAAVMLVPYPPGIPLIMPGERFTEATRSIIDYLKFARTFDSSFPGFVADVHGLQHEDEGNGRHYTVDCVKE
>CP027218.1|QAX85521.1|3861197_3861812_-|GNAT-family-N-acetyltransferase
MQPVMNPKYPGLSVRVADEGFAPYIWGSDFSFEVAAYGAAVIGKAVEHWPVTPIVPYRKCYGIDPEEFSSFRDAADSAIFMAYLDDEPVGHLVISTNWNGFAHIDELAVHAPARRHGVAKALLDVAQFWSRKKKLPGIMLETQNNNLGACRLYERCGYVIGGIDQLRYRGIDPNTAEVALFWYRLFDNPLENPLSSTASPRLVP
>CP027218.1|QAX85520.1|3860338_3861232_+|LysR-family-transcriptional-regulator
MRLRHIEVIQALLQTGHLGTAAEWLQLPVTEVEERLREAESQLGFMLFASVRGRLQSTAEARALQVEIAHVYEALEPVQRLASSLKQYLAPPLRIIGTPPLAQQLLPQSLAALRRRLPDAPCSLLSAPTRDIVRSLLLRESDLGLSLHDPEHADIDCQPLAQGKLQLLAPHGWLQPKQKYISLQDLAGQAMLGLVGQDPLSPALENKLQALRPAPSIQTRVQTHQMMRSMVEAGEGLAIVDPFTALGARAGGLDVCPLSPAVPISLYALTFKHAAPSAAIQSLLAIITEQAAAMLSS
>CP027218.1|QAX87738.1|3860022_3860253_+|hypothetical-protein
MAAVLVGQFHARDAEGRVYSVHEFQESNPSVDGITGSEPVYKLAIGDRIRKIDEQTFELVQSGITLTREPEPTVAS
>CP027218.1|QAX85528.1|3870563_3872396_+|ABC-transporter-substrate-binding-protein
MKRPLLLLLISLALSSTASATITESHGYAQFGTLKYPARFTHFDWVNPQAPKGGTLRVMAFGTFDTVNPYTFKGTSPVTTPNFLQYGINELNEPLMVGTGQYSPSGDEPASSYGLIAQSVEYSEDRSWVVFNLRPEARFHDGTPITAYDVAFSYRLLLKEGHPLYRTALQEVLRVDILNKQRIRFVLKRSGNPLLILRLGELPVLPQHYWKDRDFKATTFEPPLGSGPYRITAVTPGRQLIFERVKDYWGKDLAVNRGKYNFDRMEVEFYRDSDVAFEAFKAGEFDIYIEHQAKNWANGYNFPAIRRGDVIKAQIPHQIPTQSQGLFMNTRRATFADVKTREALGLMFDFEWTNRALFSDAYKRTTSYYPNSEFSASGLPVGHEWLMLKPYKDQLPAKLFTEPFTLPQTDGRGIPRETMRKALALLNEAGWKLNGQRLQNANGQPLSFELLLVNPNLERILQPYIENLNSIGIDARLRTVDRAQYKQRLDQFDFDMILMTLNQTLSPGLEQWQYFHSSQVAVKGSKNYAGIANPVVDHLLEQLLAARTRDEQVAAGKALDRVLLWQHYSIPNWYLNYHRLAYRNRLAFVTTPPYTLGLSAWWLKSSEKDQ
>CP027218.1|QAX85529.1|3872392_3874234_+|hypothetical-protein
MTPIRALLVQASGLLFAGLACAAPQHAVTLYNEPPKYPADFKQFDYVNPDAPKGGIFRQAGFGGFDSLNPFISKGVPADDIGQIYDTLTKHSLDEPFTEYGLIAARIEKAPDNSWVRFYLRPEARFHDGHPVRAEDVVFSFDTLTKEGSPLFRGYYSDVSEAIAEDPLKVLFKFKHSNNRELPLILGQLPVLPKHWWAHRDFSKGNLEIPLGSGPYKVAQVKAGRSVRYERVKDYWGKDLPVNRGFYNFDTMTTDYYRDNTVALEALKAGQFDYWLEMTAKNWANAYNIPAVTEGRLIKEQIANSNPTGMQGFVYNLRRPVFQDVRVRQALGLLFDFEWTNKQLFNGAYFRTRSYFENSEMAATGLPDADQRAILEPFRSKLPAQVFSEAFDNPKTDASGMIRTQQREAYQLLQEAGWKIVDDKMVDATGKPVVIEFLLAQTEFERVLLPFKRNLSDLGIDLVIRRVDVSQYINRVRSRDFDMMVGSFPQSNSPGNEQREYWMSAAADKPSSRNTMGLKDPTVDQLVENLINAESRVSLVAHARALDRVLQWGYYVVPNWHIKTWRVAYWNHIGHPKVSPKYDIGISTWWVKPDAKPAVEVETKLQADPVGTE
>CP027218.1|QAX85530.1|3874238_3875312_+|microcin-C-ABC-transporter-permease-YejB
MLAYIFRRLLLIIPTLFGILLINFVIIQAAPGGPVEQMIAKLEGFEGATSRIAGGGAEVSVAGSSYRGAQGLDPALIKEIEHMYGFDKSAPERLWIMVKNYATLDFGDSFFRDAKVIDLIKEKMPVSISLGLWSTLIMYLVSIPLGIAKATRHGSHFDVWTSSAIIVGYAIPAFLFAILLIVVFAGGSYLDWFPLRGLTSNNFDELSFGGKILDYFWHLALPVTALVIGNFATMTLLTKNSFLDEINKQYVVTAKAKGLTRHRVLYGHVFRNAMLLVIAGFPSAFIGIFFTGSLLVEVIFSLDGLGLMSFEAAINRDYPVVFGTLFIFTLLGLVVKLIGDLTYTLVDPRIDFESREH
>CP027218.1|QAX85531.1|3875313_3876333_+|ABC-transporter-permease
MNLSPLNRRRFELFKANKRGWWSLWLFLILFGASLGAELIANDKPLVVHYDNNWYFPAIKRYPETAFGGEFPLEANYKSPYIRELLKAKDAWVLWAPIPYSYQSINYDLKVPAPAPPSADNLLGTDDQGRDVLARVIYGFRISVLFALTLTVLSSIIGVIAGALQGFYGGWVDLAGQRFLEIWSGLPVLYLLIILASFVQPNFWWLLGIMLLFSWMSLVDVVRAEFLRGRNLEYVRAARALGMQNGAIMFRHILPNAMVSTMTFMPFILTGAIGTLTALDFLGFGLPAGSPSLGELVAQGKSNLQAPWLGMSAFAVLALMLSLLVFIGESARDAFDPRK
>CP027218.1|QAX85532.1|3876334_3877945_+|microcin-ABC-transporter-ATP-binding-protein
MNQDNLIEVRDLAVEFGVGERVHRVVEGVSFDIKRGETLALVGESGSGKSVTAHSILRLLPYPMARHPAGSINYAGQNLLGLSEKTIRHIRGNRIAMIFQEPMTSLNPLHSIEKQINEVLGIHKGLSGKVATRRTLELLEMVGIPEPHKRLKALPHELSGGQRQRVMIAMALANEPELLIADEPTTALDVTVQLKILDLLKELQARLGMSLLLISHDLNLVRRIAHRVCVMQRGCIVEQASCEELFRSPQHPYTRELLGAEPSGGPASNKIGAPLLEVEDLKVWFPIKKGLLKRTVDHVKAVDGINFSLPQGQTLGIVGESGSGKSTLGLAILRLIGSKGAIRFEGKQLDCLTQNEVRPLRREMQVVFQDPFGSLSPRMCVSDIVGEGLRIHKMGTAEEQQAAIIAALKEVGLDPETRHRYPHEFSGGQRQRIAIARALVLKPALILLDEPTSALDRTVQRQVVELLRSLQAKYNLTYLFISHDLAVVKALSHQLMVVKHGQVVEQGDAQSIFAAPQHPYTQQLLEAAFLAPATAQ
>CP027218.1|QAX85533.1|3877964_3878759_+|enoyl-ACP-reductase
MGFLAGKRVLIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLKGRVEEFAQGWGSSPELCFPCDVASDEEIAKVFEALSKKWDGLDCIVHSVGFAPGDQLDGDFTEATTRDGFRIAHDISAYSFVALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSLGPDGTRVNCVSAGPIRTLAASGIKNFRKMLAANEAQTPLRRNVTIDEVGNAGAFLCSDLASGISGEIMYVDGGFNTTAMGNIEE
>CP027218.1|QAX85534.1|3879056_3880022_-|GGDEF-domain-containing-protein
MLVPGKPANETVRLEVLHGLNLLDSAPEERFDRLTRLAKRLFNVPIALVTLVDKDRQWFKSCVGLDATETPRDVSFCGHAILQNDLLLVPDAREDVRFHDNPLVTGAPNIRFYAGYPLTVPNGNKMGTLCLIDTKPRELDDEERALLRDLAEMAEQELTAVQMASMDELTLLSNRRGFKQLAQHALDACARLERPATLLFFDLNDFKQINDLYGHAEGDSALKTFADVLRIAFRESDVVGRLGGDEFVALLTGSSHIETTAIMARLKEILEERNATLHRGYAIRFSVGQIEYDVKRHETVDRLLADADGAMYAHKQALKRC
>CP027218.1|QAX85535.1|3880085_3880664_-|hypothetical-protein
MKRHLLLGGVILLGLGGYASDLFADDQEALKAFGTVQKVFQSPRCQNCHIPGDSPLQFDAGIPHAMNVVRGMDGKGAAGLPCATCHAESNPPASYGPHAPPGAPHWSLPPASHKMAWIGLPPDKLCALIKDRSSNGDRDFAALLKHVNEDKLVLWGWNPGAGRAPVPVPHDIFVAQFKLWADAGGPCPVAGL
>CP027218.1|QAX85536.1|3880665_3882828_-|twin-arginine-translocation-pathway-signal-protein
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTVLLGHSEMGQGIWTGLTMLIAEELDADWSKIHVEHSPASAADYGMPGFGGMQITGGSTSTWMEFDRYRLAGATARQMLVEAAAKRFEVAPSAIRTESGVVIAGDKRATYGELADAAGQLPVPDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGASVKSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVDWDLGPLADLSSEKLLESFRKLATTQGTSASQAGDAKGSFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAEKCEIWTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMPVKTVWSREDDIRGGYYRSMFLHQAKIGLGADGLPSSWQHVLVGQSIMTGTLMEATMVKNGIDPTSVEGVADSPYVKGLANHQVDLHSPQTGINVLWLRSVGHSHTGFVMESLIDEMATAAGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAEVSQDNLVIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGAVLQSNYHDYQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>CP027218.1|QAX85537.1|3882847_3883303_-|(2Fe-2S)-binding-protein
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACITPATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTDSDIDQALSGNICRCGTYPRIRAAVKRASEIG

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Crispr_ID: CP027218_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027218_4

4225477-4225582

Orphan

Consensus_repeat	Method
GCCAACTGCGCAAGAAGTTGCGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027218_4

>merge|CP027218|4|4225477-4225582|CRISPRCasFinder
GCCAACTGCGCAAGAAGTTGCGCACTTGTTTTCAAAAAAACCCGGTAAAACGCGCTGGAAGCCTCGCCAGACGTGGCCTGCAGCCAAGTGCGCAAGAAGTTGCGCA

>CP027218|4|4|4225477-4225582|CRISPRCasFinder
GCCAACTGCGCAAGAAGTTGCGCA	CTTGTTTTCAAAAAAACCCGGTAAAACGCGCTGGAAGCCTCGCCAGACGTGGCCTGCA
GCCAAGTGCGCAAGAAGTTGCGCA

Protein	Signature genes	Signature genes Name	Protein_function
CP027218.1\|QAX85847.1\|4220718_4222173_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
CP027218.1\|QAX85849.1\|4223243_4224623_+\|DUF1338-domain-containing-protein	unknown	unknown	gnl\|CDD\|319958
CP027218.1\|QAX85857.1\|4235978_4237004_+\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX85853.1\|4228412_4229150_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379225
CP027218.1\|QAX85843.1\|4215647_4216682_+\|arginine-N-succinyltransferase	unknown	unknown	gnl\|CDD\|377426
CP027218.1\|QAX85845.1\|4217893_4219129_-\|glutamate-carboxypeptidase	unknown	unknown	gnl\|CDD\|235710
CP027218.1\|QAX85846.1\|4219372_4220443_-\|diguanylate-cyclase-AdrA	unknown	unknown	gnl\|CDD\|182329
CP027218.1\|QAX85841.1\|4213102_4214452_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|223605
CP027218.1\|QAX85855.1\|4234405_4234810_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379311
CP027218.1\|QAX85856.1\|4235478_4235853_+\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX85858.1\|4237074_4238049_-\|sel1-repeat-family-protein	unknown	unknown	gnl\|CDD\|276807
CP027218.1\|QAX87750.1\|4235081_4235375_+\|barnase-inhibitor	unknown	unknown	gnl\|CDD\|240165
CP027218.1\|QAX87749.1\|4230376_4233850_+\|type-IV-secretion-protein-Rhs	unknown	unknown	gnl\|CDD\|225750
CP027218.1\|QAX85851.1\|4225773_4226289_+\|type-VI-secretion-system-tube-protein-Hcp	unknown	unknown	gnl\|CDD\|213799
CP027218.1\|QAX85854.1\|4233846_4234233_+\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX85852.1\|4226380_4228423_+\|type-VI-secretion-system-tip-protein-VgrG	unknown	unknown	gnl\|CDD\|274542
CP027218.1\|QAX85844.1\|4216901_4217771_+\|oxaloacetate-decarboxylase	unknown	unknown	gnl\|CDD\|225311
CP027218.1\|QAX85848.1\|4222194_4223124_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|184875
CP027218.1\|QAX85850.1\|4224691_4225369_-\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
CP027218.1\|QAX85842.1\|4214569_4215586_+\|arginine-N-succinyltransferase	unknown	unknown	gnl\|CDD\|377426

Protein	Function_ID	Function_description	E-value
CP027218.1\|QAX85847.1\|4220718_4222173_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	3.67135e-93
CP027218.1\|QAX85849.1\|4223243_4224623_+\|DUF1338-domain-containing-protein	gnl\|CDD\|319958	cd16348, VOC_YdcJ_like, uncharacterized metal-dependent enzyme similar to Shigella flexneri YdcJ. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	0
CP027218.1\|QAX85853.1\|4228412_4229150_+\|hypothetical-protein	gnl\|CDD\|379225	pfam13503, DUF4123, Domain of unknown function (DUF4123). This presumed domain is functionally uncharacterized. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important. This domain is sometimes associated with the FHA domain.	1.09775e-22
CP027218.1\|QAX85843.1\|4215647_4216682_+\|arginine-N-succinyltransferase	gnl\|CDD\|377426	pfam04958, AstA, Arginine N-succinyltransferase beta subunit. Arginine N-succinyltransferase EC:2.3.1.109 catalyzes the transfer of succinyl-CoA to arginine to produce succinyl-arginine. This is the first step in arginine catabolism by the arginine succinyltransferase pathway.	5.62156e-173
CP027218.1\|QAX85845.1\|4217893_4219129_-\|glutamate-carboxypeptidase	gnl\|CDD\|235710	PRK06133, PRK06133, glutamate carboxypeptidase; Reviewed.	0
CP027218.1\|QAX85846.1\|4219372_4220443_-\|diguanylate-cyclase-AdrA	gnl\|CDD\|182329	PRK10245, adrA, diguanylate cyclase AdrA; Provisional.	5.16958e-88
CP027218.1\|QAX85841.1\|4213102_4214452_+\|amino-acid-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.58688e-41
CP027218.1\|QAX85855.1\|4234405_4234810_+\|hypothetical-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	0.00011634
CP027218.1\|QAX85858.1\|4237074_4238049_-\|sel1-repeat-family-protein	gnl\|CDD\|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	2.33518e-31
CP027218.1\|QAX87750.1\|4235081_4235375_+\|barnase-inhibitor	gnl\|CDD\|240165	cd05142, Barstar, Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.	3.33073e-19
CP027218.1\|QAX87749.1\|4230376_4233850_+\|type-IV-secretion-protein-Rhs	gnl\|CDD\|225750	COG3209, RhsA, Rhs family protein [Cell envelope biogenesis, outer membrane].	1.45614e-44
CP027218.1\|QAX85851.1\|4225773_4226289_+\|type-VI-secretion-system-tube-protein-Hcp	gnl\|CDD\|213799	TIGR03344, VI_effect_Hcp1, type VI secretion system effector, Hcp1 family. This family includes Hcp1 (hemolysin coregulated protein 1), an exported, homohexameric ring-forming virulence protein from Pseudomonas aeruginosa. Hcp1 lacks a conventional signal sequence and is instead exported by means of the type VI secretion system, encoded by a pathogenicity cluster of a class previously designated IAHP (IcmF-associated homologous protein). Homologs of Hcp1, in this protein family, are found in various bacteria of which most but not all are known pathogens. Pathogens may have many multiple members of this family, with three to ten in Erwinia carotovora, Yersinia pestis, uropathogenic Escherichia coli, and the insect pathogen Photorhabdus luminescens. [Cellular processes, Pathogenesis].	2.00413e-94
CP027218.1\|QAX85852.1\|4226380_4228423_+\|type-VI-secretion-system-tip-protein-VgrG	gnl\|CDD\|274542	TIGR03361, VI_Rhs_Vgr, type VI secretion system Vgr family protein. Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.	0
CP027218.1\|QAX85844.1\|4216901_4217771_+\|oxaloacetate-decarboxylase	gnl\|CDD\|225311	COG2513, PrpB, PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism].	6.16182e-78
CP027218.1\|QAX85848.1\|4222194_4223124_+\|alpha/beta-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	8.73869e-37
CP027218.1\|QAX85850.1\|4224691_4225369_-\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	1.31112e-107
CP027218.1\|QAX85842.1\|4214569_4215586_+\|arginine-N-succinyltransferase	gnl\|CDD\|377426	pfam04958, AstA, Arginine N-succinyltransferase beta subunit. Arginine N-succinyltransferase EC:2.3.1.109 catalyzes the transfer of succinyl-CoA to arginine to produce succinyl-arginine. This is the first step in arginine catabolism by the arginine succinyltransferase pathway.	7.05996e-148

>CP027218.1|QAX85850.1|4224691_4225369_-|type-1-glutamine-amidotransferase-domain-containing-protein
MKILMVLTSHDQLGNTGKKTGFWLEEFAAPYYVFKDAGAQLTLASPKGGQPPLDPKSDEPDAQTAATERFRKDSAAQSALAATVKLDSVKAADFDAVFYPGGHGPLWDLAEDRHSIALIEAFYNSGKPVAAVCHAPGVLRHAKGADGQPLVKGKQVTGFTNSEEEAVQLTKVVPFLVEDELKAKGGIFSKGADWSNYTREDGLLLTGQNPASSEETALALLSRLR
>CP027218.1|QAX85849.1|4223243_4224623_+|DUF1338-domain-containing-protein
MTVQPFVSPDLIRQRFSKAMSDMYREEVPLYGALLQLVEQTNHDVLEREPQIAAQLHNSGEIERLDMERHGAIRVGTASELATLARLFAVMGMQPVGYYDLTPAGVPVHSTAFRAVHEDALQISPFRVFTSLLRLELIKDPELRAFAESVLAKRTIFTPAALHLIERAETIGGLNADESEEFVLQALETFRWHHSATVSAAQYQTLSAQHRLIADVVAFKGPHINHLTPRTLDIDIVQAQMPAHGITPKAVIEGPPRRQCPILLRQTSFKALDEPIAFTDQNQTRGSHSARFGEIEQRGAALTPKGRALYDRLLNAARDELGDFPNEGNAARYNALMTQHFGEFPDSIEGMREQGLAYFRYFATEKGLAAGSLAQTSLEDLLRDGHVKAEPLVYEDFLPVSAAGIFQSNLGDAAQTHYGEHSNRQAFEQALGRTTIDELQLYAETQQRSLDECLAAISK
>CP027218.1|QAX85848.1|4222194_4223124_+|alpha/beta-hydrolase
MLLLFVALAVFVAWSWLSYPAVGHWLYDLSMAVEAKLYKLHKIEVPIAEMTVSTWQGGPYEAASAILMLHGYSAEKNLWLRFSRHFVRQYRVIIPDLAGHGETGFKAGGGYDIPLQAKRMIQLLDVCGVEKVHVIGNSMGGYIAAWLAATYPERIASVALIDPAGVTAPEVSDMERHLARGHNPFLINSREEFRRFYAMTMASPPWVPGLVLDAIAQRYEQQRDDLEEIFRDFRASPPMEPKLADIKCPALLLWGRKDRLIDVSSVPIWSKGIANLQVEVWEGVGHMPMVEHPASTARLYRQFLGQQVH
>CP027218.1|QAX85847.1|4220718_4222173_+|NAD(P)/FAD-dependent-oxidoreductase
MQTYQVLIIGSGFGGQCAAVNLLKAGIEDFRLLERRDFFGGTWCQNTYPGAAVDVPSPLYSLSFAPYRWSQMFAEQAELHRYTEHVIEQFNLRERVELQANVERVEWDDTEKRWAVHTASKGTFYAQFLINASGPLSQPVIPQIPGQDRFQGKTFHTNNWDHSYDYRGKRVAIVGSGASAVQVIPTIAPQVEQLHVFQRTAHWLLPRADRRFGAFQRWLLGLKPAYKLLRWLIYWQFETRVIAFKYSRPAIHMVQRQAMRLLERQVPDPVMRAKLTPDFTIGCKRVLLSNTYYPALTRANVMLHTREQGIASLDESGINTTDGQHIDVDLIVWSTGYDATDGVISYPVSGKNAVQLRDVWAEYPRAYLGTSLPGFPNLFFITGPNTGIGHTSALFIIESQMNYILDCIRTVQAKGLSSIEVRPEAERTYTAMIHREMQRTVWKSGGCHSWYQSKSGHVIAMFPGFSFSYHRLTRALKPADHIFS
>CP027218.1|QAX85846.1|4219372_4220443_-|diguanylate-cyclase-AdrA
MGNTGGKGLSLARRLYTSRTLGLALGLMCVSVAMYPLDPPLWVWALMLFNGLVWPHLAFQWARRSSVPYHAEHRNLLVDSFLGGFWVAAMHFNPLPSATTVSMMAMNNVAIGGLRFLLAGAAAQILGVGVGLVVFAPAFIPQTSPLQLYACLPLLMLYPLALGWICFRQAYTLGQHKRELLALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQQQGAAIALIDIDHFKSINDTYGHVAGDIVLRQLSKMLRQNLRATDVAGRYGGDEFCVILPELPLFNAAQAMEALRERFATLGYEQNPALKVSLSIGLAAYDPSHADATRWLNDADQALYEAKASGRNRVICNCDKPRRELLDSV
>CP027218.1|QAX85845.1|4217893_4219129_-|glutamate-carboxypeptidase
MTFSFSRSLLAASLGLALALSAANAFAEPHKQVLADAEQYQPEALKLLERLVNIDSGSGYEPGLKQVSEIAIDELKKLGATIELVPNTPEKSNHVLATFKGTGKAKILLMAHMDTVFKEGSAAERPFHIKDGRAYGPGVMDDKGGIVAGIYALKVLKNLDFKNYAQITFLLDASEETGSDVATDLIKKTAKLHDVTLNLEPGRPADGLVVWRKGSATALVEVKGKAAHAGVAPELGRNAAMEVAHQILQLGKLGDEEKKTTINFTVLKAGDRTNVIPDQATAKADVRAAVPEEFDRIEKDLARVSQNKLIADTEVKTSLQRGLPPMPQTPESDRLMAMAQGIYGEIGRKLTEEGSGGAADASLSAGVGTPTLDGFGIVGGNIHTPEEYAEVASVAPRIYLLSRMIMELSKP
>CP027218.1|QAX85844.1|4216901_4217771_+|oxaloacetate-decarboxylase
MTRLSHQDLRRSFRQLLASDTCYHTASVFDPMSARIAADLGFEVGILGGSVASLQVLGAPDFALITLSEFAEQATRIGRVAQLPVIADADHGYGNALNVMRTIVELERAGVAALTIEDTLLPAQFGRKSTDLITVAEGVGKIRAALEARVDTEMAIIARTNAGILPTQEIISRTLQYQNAGADGICMVGVRDFDHLEQIAENLNVPLMLVTYGNPLLRDDKRLAELGVRVTIDGHGAYFAAIKATYDSLREQRQIFTQAADLNATELTHTYTQPEEYIRWAEEFMSVKE
>CP027218.1|QAX85843.1|4215647_4216682_+|arginine-N-succinyltransferase
MIVRPVNVSDLPALMTLVQQAGPGFTTLPANEDRLAHRVRWAQRAFAEQVERADADYLFVLEDDDTHVVGVSALAGAVGLREPWYNYRVGLTVSSAPDLGIQRQIPTLFLNNELTGQSELCSLFLRHDQRTGSNGRLLSLGRLLFAAEFPQLFGEKMIAELRGSADEKGCSPFWDSLGRHFFQMDFSHADHLSGLGNKSFIAELMPRQPLYTCLLTEQAQAAIGQTHPNTEPALKILQAEGFAHKGYIDIFDGGPVIEAPLRSIRTVRDSLELTLSLGTPDEQAPLWLIHNRRLENCRITVARARRVGSSLAIDRATAQRLQLQPGNSVRAVMLPNQQRQAVAA
>CP027218.1|QAX85842.1|4214569_4215586_+|arginine-N-succinyltransferase
MLVLRPVEPTDLPQLQQLARDSMVGVTSLPDDSERLCDKIAASCASFDSEAQTQGPENYFFVLEDCATQRLVGCSEILATAGFKEPFYSLRNRHFTSASRELNIEHGVPALSLCHDLNDHTLLRGFHIDKALVRTPFSELLSRARLLFIAAHAPRFAEAVITEIVGYSDEEGHSPFWDALGKHFFDLPYVEAERLCGLQSRSFLAELMPQYPIYVPMLPQAARECIGRIHPDGQEAFDILEREGFETNSYIDLFDAGPTLYARTSNIRSIVRSQTAPVQQLPEIDARGRYLLSNDAWRGYRAIVAELDYQADQPLSLTPAMCAALNVTDGSQIRLIAL
>CP027218.1|QAX85841.1|4213102_4214452_+|amino-acid-permease
MEIEEFGYKQELKRSLTLTDLVVYGMIFMIPIAPFGVYGYVNAEAPGMVPLAYIIGMVAMLFTALSYGSMARAFPIAGSVYSYAQRGLNPHVGFIAGWLMLLDYLLIPPLLYVYAAMALNHLYPDIPKVGFILAFLVSATFVNLRGITFTARMNIIFLLAQLVVLGIFLFYAWNALHNGGGNGELTLAPLYHPETFNFALLMQAVSIAVLSFLGFDAISTLAEEIKGDPGRSVGKAALITLVVMGVIFVVQTWIATDLAAGMGFNSADTAFYEIAEIAAGSWLATLTAVATALAWGVAVAITSQAAVSRLLFGMARDGKLPKVLAKVHPKHNTPYLSIYLVAVLSLIICYLFINSVDTLTSLVNFGALSGFMLLHLTVINYYWRRQKSGQVVRHLICPVIGFIIVAAIMYNMGVDAQKLGLIWIVLGLVYLFFLNKLGASTALPDPSNG
>CP027218.1|QAX85851.1|4225773_4226289_+|type-VI-secretion-system-tube-protein-Hcp
MATPAYMSVTGEKQGLITAGAFTADSVGNTYQEGHEDQVMVQAFSHDVIIPRDPQSGQPTGQRVHKPVVITKVYDKASPLLQAALTSGERMSEIVIQWFRTSAQGTQEHYYTTKLEDAIIVAINNKMHNCQDPGNSHFTHLEEVQFTYRKITWTHEVSGTSGSDDWRAPVV
>CP027218.1|QAX85852.1|4226380_4228423_+|type-VI-secretion-system-tip-protein-VgrG
MFAPANETHFALTIEGLSADFQVFTLQGREAISQPFVFEVELVSEQPSLDLETLLHKPAFLQLSPDGSGIHGQIYRAAQGDSGKRLTRYSLTLRPQLSYLAHRINQRIFQNLTVPKIIGKVLEEHGIQSNAYEFKTGSIYPERVYCVQYDESDLHFIQRLCEEEGIHYHFEHTATAHKLIFGDDQTVFPKLAPVAYQQDSGMVASDPVIKRFDLRLETRTSRTTRRDYDFEKPRITLESENRGDALPDLEDYDYPGRFVDRERGKHLAKRALERHRSDFQLAEGKSDQPLLVSGHFLALTAHPKAKWNDLWLLTEVLHEGKQPQVLEESVTSDTTALKDDFHQGYRNRFQATPWDVPNRPPLRHPKPRILGSQSAVVTGPKGEEINCDEYGRVKVQFHWDREGQADDKTSCWLRVSSAWAGAQYGGIAIPRIGMEVLVTFLEGDPDQPLISGCLYHKENTVPYPLPANKTRSTFKTLSSMGGGGYNELRIEDKKGQEQIYLHAQRDWDENIEHDQKIRVGNERHDTVEKNSYSEFKAEEHHTVYEDRKVEARANDHLTVGVNQHIKIGTGQFIDAGQEIHLSSGMKVVMEAGAELTLIGGGSFIKIDAGGVTMSGPVINMNSGGGPGSGTGAAPLIPGVLKQADADKAGQVLTPAQINTLKRNAPFCEECEKCKAGACAI
>CP027218.1|QAX85853.1|4228412_4229150_+|hypothetical-protein
MPSDRITPKDWLAQQPLQTGERLYLVISAASDSDALKNLYLTEPTAQLLPIWGGTPYSTWQPVMPYVTELKGNSAFLPWIAETDALDWGWLAVSRSEPNEVFEHLRSLTQVKMPDGTEVFFRFWDGRHIYPILHELGDKAGEVLPVFERYLINGQTLEVGTRVVPKVKDWPWWEVPKPLLDGLAKENPTTLISNLMQWLEEDRPDIYTVWPESNLRLKISRFVRRPDAPKNLKEALLNHLILEQG
>CP027218.1|QAX87749.1|4230376_4233850_+|type-IV-secretion-protein-Rhs
MVTGEELLTLTDGQLDGLLPFEWTRLYRTSAVEIDCGLGYGWSHALAHRIDINGDEVIWTDHENRATPFPLPSEQRPAISNSLSKAAIFLGDDPSELILAQAGKRPSFYHFRFNSKGATLIAISDSYGNRLHVTRDIHGRIKRLDNGAGRALLLRYDRKHIVAVDYQQFLPADNLEDAWNTVQTLVTYSYDAQHRLIEAKNAAGEAERYRYNEQHVILERQLAGGAAFYWEWENEGKLSRCTRHWANFSQMEAQYAWDDKGSVTVTNADGSEEVYTHDDQARLISKIDPDGAQHLKAYDDKGRLIAEKDPLGAVTEYRYDDNGLMTAIIPPEDEATTYEYVNGFVSDVHRGKASWKYQRNRQGDITQQTDPDGNTTLYSYDSQGRLLEIRHPDGSRHQLGWNNLGQLLEERLPDGGQRKYRYDALGRQITRQEESGAITQYQWDAANRLAQVTLPGGVTRTFTYNAYGNVTAERDELGRITRYEYAENLHLVSRRINPDGSQLRYRYDNSRLLLTEIENERGEQYHLDYYANGLIQQETGFDGRRTAYEYDLNGQLLKKTEFGDDGSELVTEYQRDAAGRLLVKTLADGEEIHYGYDALGRLVNVDDDHWPLAYKYDLQDRLIEEHQGWGTLRYEYDSVGQLKHCRLPDGSELDYRHQPGGQLSSIDLNGSRLTSHQFSAGREQKRQQGLLLSQYQYDEQGRLQAHTVGQRDKNLFQRRYNYDANGNLAGIDDSRKGNRSYHYDPLDRLISVRGATPESFAHDPAGNLLGQNNEGTANLANVKGNRLLMQGDRHYEYDAYGNLSRERRGTGQKLVTEYRYDCQHRLIGVSLPGGSTATYKYDAFGRRIEKTVDGHITEFLWQGERLIAESAENRYRSYIYEPGSFRPLAMLDGEGPRKATPFYYQLDHLGTPQELTDYSGEIMWSAKYRAYGNLAALDVSEIDNPLRFQGQYFDAETGLHYNRHRYYNPSTGRFLTPDPIKLAGGLNSYQYVPNPTGWVDPLGLNGCPPDGEGKGNSTAPTENAKIDTKEPTLPDVDWSSPSVKRASAQLDQGAKDVTVNSRAEAEELFRGKYVGQGYRNAEEFNSVTAKDYFQTPQGKESYYHWDDTPVSNLETRKVYMANHSPTDPHAAMPHLQLHPKDGKVIRIYWPNPFEGQK
>CP027218.1|QAX85854.1|4233846_4234233_+|hypothetical-protein
MTEQKKIPRSVWYGLDGTGYDNIAQEMASEDPLMRKWVSIYAIYKYQFTEDPHQYFDFIHNSKNSKYALIIFTIPVEKINTNDGLDDRDIIISEIKTMDSEEEINTSLATLKIDPELFAPPWRCDYPL
>CP027218.1|QAX85855.1|4234405_4234810_+|hypothetical-protein
MNKIFEEYNYWLGPNEDSNWNEYITEQVAYGVLRKFNIMNWQQLNEAILLKEEYWQERSAAALGELRSPEAIEVLKKLLDSRFSEVAIAAASELDWTEAAIEEKYSNKIQRIIDNLPDEEIDCYPELKNLLKKS
>CP027218.1|QAX87750.1|4235081_4235375_+|barnase-inhibitor
MNMIIQLDGSSISTEEESHKQISSSFSVTQYYGNNLNALWDLLSTDIERPIELIWTNSNHSEKLMGDSYKKILIILDRVKIQDESFGLNDKFNYQLK
>CP027218.1|QAX85856.1|4235478_4235853_+|hypothetical-protein
MKTHLNIDDLPDYPYPANFIKFASIEPETDIEPWWLLVYNEGTINNWYKTLKQLYPKRTLIPFAKFNANDDIACFDGDDFSGQPQVLIIHAYASENWELHATYASFDKWLEEAMVQNAEWLNED
>CP027218.1|QAX85857.1|4235978_4237004_+|hypothetical-protein
MKRLNRPFSILLALTFSLNATALSLRSEQRPDGTTALLLSNESAAERAPKLNQDPAVRSALVDFFGYQTGSYTNDNTMIVQQVLEALDSEMSTFADGVPAGSKMITAMDDGNNGFERGALLLNDKGQLVAVGLVNGHCAVKSREEALTCNDAPQTVLTIFQPQGAKQPDAESLIGWSKQLPPMMAIWAESDDPERRANAQKIASVEYAATKPEQGAWTAAQLPSDFPKAMLAMLPQRAHLIGAGAHGVFTTPGMEGTPIEGDWDKIAGRPQHEFEVILRTFTEYADVIDFYQQHAKDAEISGNQRKALVEGYIGGGTYKIEISNRKDEGTVITLSAWGQEV
>CP027218.1|QAX85858.1|4237074_4238049_-|sel1-repeat-family-protein
MSNRFKTVGTASTVLFSMLIACNTWAQPPRDYYDGMKAGKCAPNSERLHEQAVAGDLDAQTQFGKAIQENLCGVVEQWSPGMPEVWFRKAAEQGNAEAQVGLAEELRWDRSVEGEDAGVYWDLKAAEQGNAKAQFSLAQIYHRGGRSIKNIKDMDKALAYYHQSAEGGYPSAYMLLASLYEKGDGVTQDDVVAAQWYRKLAETGDDYGQLNLAEMIAAGRGIDKDEALAFTWFGKSAALGNKYAQYEMAQMLEQGRGTVKNQREAAKLYRKSADADFGNAQLALGKMYAQGRGGLPKSKSKAEYWMLKAIDRGAPGAKEELQKL

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Crispr_ID: CP027218_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027218_5

4514082-4514210

Orphan

Consensus_repeat	Method
GTAGGAGCTGCCGCAGGCTGCGATCTTTTGATGTTGTTTTAAAAAGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027218_5

>merge|CP027218|5|4514082-4514210|CRISPRCasFinder
GTAGGAGCTGCCGCAGGCTGCGATCTTTTGATGTTGTTTTAAAAAGACAAGACCAAGAGATCGCAGCCTTCACCAATCCCTGTAGGAGCTGCCGCAGGCTGCGATCTTTTGATCTTGTTTTAAAAAGAC

>CP027218|5|5|4514082-4514210|CRISPRCasFinder
GTAGGAGCTGCCGCAGGCTGCGATCTTTTGATGTTGTTTTAAAAAGAC	AAGACCAAGAGATCGCAGCCTTCACCAATCCCT
GTAGGAGCTGCCGCAGGCTGCGATCTTTTGATCTTGTTTTAAAAAGAC

Protein	Signature genes	Signature genes Name	Protein_function
CP027218.1\|QAX86107.1\|4516415_4518149_+\|thiol:disulfide-interchange-protein	unknown	unknown	gnl\|CDD\|234717
CP027218.1\|QAX86097.1\|4507247_4507823_+\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX86101.1\|4510528_4511434_+\|metal-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223874
CP027218.1\|QAX86103.1\|4511929_4513342_-\|diaminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|235892
CP027218.1\|QAX86114.1\|4536022_4536820_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223904
CP027218.1\|QAX86100.1\|4509628_4510528_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224033
CP027218.1\|QAX86098.1\|4507857_4508787_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238499
CP027218.1\|QAX86109.1\|4519005_4519776_+\|thiol:disulfide-interchange-protein-DsbG	unknown	unknown	gnl\|CDD\|183262
CP027218.1\|QAX86112.1\|4534273_4534828_+\|RNA-polymerase-factor-sigma-70	unknown	unknown	gnl\|CDD\|180803
CP027218.1\|QAX86113.1\|4534921_4535935_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379237
CP027218.1\|QAX86106.1\|4515580_4516261_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|182612
CP027218.1\|QAX86105.1\|4514258_4515581_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|182388
CP027218.1\|QAX86110.1\|4519886_4520711_-\|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase	unknown	unknown	gnl\|CDD\|131480
CP027218.1\|QAX86111.1\|4520903_4533902_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|235564
CP027218.1\|QAX86104.1\|4513485_4513971_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
CP027218.1\|QAX86095.1\|4506373_4506913_+\|thiamine-pyrophosphate-binding-protein	unknown	unknown	unknown
CP027218.1\|QAX86108.1\|4518148_4519030_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239264
CP027218.1\|QAX86102.1\|4511621_4511846_-\|MbtH-family-protein	unknown	unknown	gnl\|CDD\|225790
CP027218.1\|QAX86096.1\|4506909_4507251_+\|hypothetical-protein	unknown	unknown	unknown
CP027218.1\|QAX86099.1\|4508783_4509629_+\|manganese-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046

Protein	Function_ID	Function_description	E-value
CP027218.1\|QAX86107.1\|4516415_4518149_+\|thiol:disulfide-interchange-protein	gnl\|CDD\|234717	PRK00293, dipZ, thiol:disulfide interchange protein precursor; Provisional.	0
CP027218.1\|QAX86101.1\|4510528_4511434_+\|metal-ABC-transporter-substrate-binding-protein	gnl\|CDD\|223874	COG0803, LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism].	9.35181e-21
CP027218.1\|QAX86103.1\|4511929_4513342_-\|diaminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|235892	PRK06938, PRK06938, diaminobutyrate--2-oxoglutarate aminotransferase; Provisional.	0
CP027218.1\|QAX86114.1\|4536022_4536820_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|223904	COG0834, HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms].	2.94587e-12
CP027218.1\|QAX86100.1\|4509628_4510528_+\|metal-ABC-transporter-permease	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	2.44081e-50
CP027218.1\|QAX86098.1\|4507857_4508787_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238499	cd01017, AdcA, Metal binding protein AdcA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AdcA proteins belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and they bind their ligand in the cleft between these domains. In addition, many of these proteins have a low complexity region containing metal binding histidine-rich motif (repetitive HDH sequence).	7.34565e-118
CP027218.1\|QAX86113.1\|4534921_4535935_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.02139e-68
CP027218.1\|QAX86099.1\|4508783_4509629_+\|manganese-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	1.16503e-87
CP027218.1\|QAX86110.1\|4519886_4520711_-\|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	2.64461e-39
CP027218.1\|QAX86105.1\|4514258_4515581_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|182388	PRK10337, PRK10337, sensor protein QseC; Provisional.	1.55734e-56
CP027218.1\|QAX86112.1\|4534273_4534828_+\|RNA-polymerase-factor-sigma-70	gnl\|CDD\|180803	PRK07037, PRK07037, extracytoplasmic-function sigma-70 factor; Validated.	6.68679e-107
CP027218.1\|QAX86111.1\|4520903_4533902_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|235564	PRK05691, PRK05691, peptide synthase; Validated.	0
CP027218.1\|QAX86106.1\|4515580_4516261_-\|DNA-binding-response-regulator	gnl\|CDD\|182612	PRK10643, PRK10643, two-component system response regulator PmrA.	3.62904e-76
CP027218.1\|QAX86109.1\|4519005_4519776_+\|thiol:disulfide-interchange-protein-DsbG	gnl\|CDD\|183262	PRK11657, dsbG, disulfide isomerase/thiol-disulfide oxidase; Provisional.	1.40582e-148
CP027218.1\|QAX86102.1\|4511621_4511846_-\|MbtH-family-protein	gnl\|CDD\|225790	COG3251, COG3251, Uncharacterized protein conserved in bacteria [Function unknown].	6.63361e-33
CP027218.1\|QAX86104.1\|4513485_4513971_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.49449e-15
CP027218.1\|QAX86108.1\|4518148_4519030_+\|peroxiredoxin	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.00027e-34

>CP027218.1|QAX86104.1|4513485_4513971_-|GNAT-family-N-acetyltransferase
MDAPIYIYAATPADSGIISRIIERSIRVGCALDHRNDPRLVNTWVRQQSAERITAWLVDPHFYLNIALLADKPVGVGMAASSGDVTFCHVQPEWFRRGAGRALMADLEGWLRIRGRPGVALKSTRTGEAFYRHLGYRESAPALLHHGVKATPMHKSLAVPA
>CP027218.1|QAX86103.1|4511929_4513342_-|diaminobutyrate--2-oxoglutarate-transaminase
MSVATSLIEESSARVSSAPAETLYQFNESPLLARQSQQESNARSYPRRIPLALKRAKGLYVEDVEGRTFIDCLAGAGTLALGHNHPVVIEAIQQVLADELPLHTLDLTTPVKDQFVQDLFGLLPRELAAQAKIQFCGPTGTDAVEAALKLVRTATGRSTVLSFSGGYHGMSQGALSLMGSLGPKKPLGALLSNGVQFMPFPYDYRCPFGLGGAAGVKANLSYLENLLNDPEAGVQLPAAVIVEAVQGEGGVIPADIEWLRGLRRITEKAGVALIVDEIQSGFARTGKMFAFEHAGIIPDVVVLSKAIGGSLPLAVVVYRDWLDTWQPGAHAGTFRGNQMAMAAGSAVMRYLVEHKVCEHAAAMGERLSEHLRILQRDFPQLGDIRGRGLMLGVELVDPAGAPDALGHPPAFARLAPLVQRECLKRGLILELGGRHGAVVRFLPPLVITATEIDRVAEIFGRALIAATAAL
>CP027218.1|QAX86102.1|4511621_4511846_-|MbtH-family-protein
MTSVFDREDILFQVVVNHEEQYSIWPDYKAVPEGWRTVGKSGLKKECLAYIEETWTDMRPLSLRQKMEAQVAAQ
>CP027218.1|QAX86101.1|4510528_4511434_+|metal-ABC-transporter-substrate-binding-protein
MTFSLRKLSLAMALCGVMGTPLLAAENTKPLRVLASLPITYGLGEVLLKGTDVNLERAAPANLPGSRQTAYFTGRGAPALSKLATGADAVIGVRSLWADDPLYPIARRSNIRIVEVDAARPVDGALPGIAVQPELKVDGLNSQPWLASNNMGRMADVMAADLVRLAPSAKPKIEANLAALKQRLLKLSADSEARLASADNLSVMSLSDHFGYLIGSLNLELIGEDPRPDAEWTPEDLKKLTATLKDNDVAVVLHHRQPSEAVKAAIAESGSHLVVLSTDAADPVAELEGNVDLLLKGLSGA
>CP027218.1|QAX86100.1|4509628_4510528_+|metal-ABC-transporter-permease
MSYEAFRLMVQGWASSGYLPEALAYGFVVNALLAGLLIGPVLGGLGTLVVVKRFAFFSEAVGHAALTGVAIGILLGEPYTGPYGSLFGYCLLFGILLNYLRNRTGLAPDTLIGVFLSVSLALGASLLLILAGKINVHILENVLFGSVLTVNGNDLAVLAIVGSLVMALALPLYNRIMLASFNPQLAAVRGVAVKTLDYLFVILVTLITVAAVKVIGAILVGALLVIPAAAARLLSQSLKGFFWCSVLIATVSTLCGILAPIVFDLPIPSGAAIILVAGIAFALAAIARGVVPSLKGNLG
>CP027218.1|QAX86099.1|4508783_4509629_+|manganese-ABC-transporter-ATP-binding-protein
MTSKETISDELQSPVGAGLLANAVSHSPQVAPDTTPSRASPLPQVSGPTLDFSEVCLTLGRTTILDKVTFQVRPGSVHALVGPNGGGKSSLIKTLLGQMPHQGQLSLQWPGAPGTIGYVPQALEFDRGLPMTVDDFMAAMCQRRPAFLGLSKHYAGAIGEALERVGMQDKRKRRMGALSGGERQRVLLAQGLIPAPQLLVLDEPMSALDEAGIQVFERLLNDWRAAGITVLWIEHDLEAVGRLANHVTGLNRRVLFDATPQQALTPERLLTLFSTHPRSAV
>CP027218.1|QAX86098.1|4507857_4508787_+|ABC-transporter-substrate-binding-protein
MSISSPRRPLLRLFLVGLCACLLSPLASADPAKRLRIGITLHPYYSYVANIVGDKADVVPLIPAGFNPHAYEPRAEDIKRISGLDVIVLNGVGHDDFADRMIAASETPNIKTIEANENVPLLAATGVAARGAGKVVNPHTFLSISASIAQVNNIARELGKLDPDNARTYTQNARAYGKRLRQMRADALAKLTQAPNAELRVATVHAAYDYLLREFGLEVTAVVEPAHGIEPSPSQLKKTIDQLRELDVKVIFSEMDFPSTYVETIQRESGVKLYPLSHISYGEYTADKYEKEMTGNLNTVVRAIQESGA
>CP027218.1|QAX86097.1|4507247_4507823_+|hypothetical-protein
MSTPTTQIVRPAGAGHETLNVLLLCLLILAIAGSVVAWRGVSHEPEPVASNQLDARRDLSAAEQGIYADLRVTLDEIHLLREEQKALPTPQNLADEGFAPFAQDASSVSRGGHVWQMLAGTAYYGHSQTPAVAGSFLMRVSADDKAAPDIWLSRDADLKPAADLSDAALSAAGWKQIVAQYDAGVTREHRH
>CP027218.1|QAX86096.1|4506909_4507251_+|hypothetical-protein
MSHTKRPSRLGLSTALLVLCTGFSASALAHNPMCECKAVDAEQIKCTGGFSDGSGAPGVTLDVIGYDETILLPGKLGSDSTLTFKKPGAEFYVLFDAGPGHVVEIDQADIETP
>CP027218.1|QAX86095.1|4506373_4506913_+|thiamine-pyrophosphate-binding-protein
MSQTTSIAQPSRLSRFWHKWRFHINVLLLLIPLGFMPKYFADVALFRGDSGLGEREIGEVQVGPWSLRLAELRNEAPLNGPAGFMKDFNAALCDACIEQVKATYLRIGKPRSLRAAGVIFFGTPYRMGTQLLIPEKTKTDAELWITMEGWDGNMHQASIPLSQASPATIAWLNKQGAKP
>CP027218.1|QAX86105.1|4514258_4515581_-|two-component-sensor-histidine-kinase
MSLRLRLSLTLGAAFALIWALAAAWMLSDLRNQMMFSLDQRLVASARMVAGLLEQLPTLPSKGEGTHFSAEQLNIPGGMACQVSSLRGEILARSHNNPEQALEAEKMGFHDQMIDGAPWRSFTLARGDVRITTADRQIEREALNMSILLAASVPVGVALLGCLCLLWLGIGQGLAPLNRLREALMRRNADSLEPLQLQAFPSELKPLLDTQNQLFQRIAKTIERERRLTGDAAHELRSPLTAIKTHLQVARMTEGNARDQSLARAEEGADRMHRTLEQLLLLARVEGSLSFDDGVQCSAEQVARLAIQDATGGERLRIKLQLPDDLSTAALQMPAVLSIAALRNLLDNALRHTPEDCAVELSLETLGNRVRYVVRDHGPGIATDDLQHLTQRFWRNGQSTGCGLGLAIVQAIVQRCECALHFDSRPDGLRVELSMPLQPV
>CP027218.1|QAX86106.1|4515580_4516261_-|DNA-binding-response-regulator
MHVLVCEDDELIASGIVAGLTAQGLTVEHVNTASKARAMLKVAEFDVMVLDLGLPDEDGLKLLQQLRQGGLEIPVLILTARDSVTDRVDGLQAGADDYLLKPFDLRELFARLQTLLRRVAGRSVNLIEHGALTYDPSSRETRLGGQAVDLSRREQSLLQALLHNRGRVLSTEQLKDSVYGFNDELESNALNVHIHHLRSKLGKGIVETVRGLGYRLGPADGGDQGK
>CP027218.1|QAX86107.1|4516415_4518149_+|thiol:disulfide-interchange-protein
MRHFFLLFALLLSGLAQAGNNPFETKPEFLPVDKAFVLTSERLESGETQLFWQITDGYYLYQKRLKFDGLTAQQQPALPEGESHSDEYFGEQPVYRQGLEVKIPASASGQIKVSYQGCADAGLCYPPQTRVIDLGGKAPSTTATEAPDQALASGLQQHALGWSLLVFFGLGLLLAFTPCTLPMLPILAGMVVGSGATPRRGFALASSYVICMALVYAAMGVIAALLGANLQAWLQNPWLLGTFAAIFVVLALPMFGFFELQLPVALRDRLEHASRSRSGGSLIGAGVLGALSGLLVGPCMTAPLAGALLYIAQSGNALHGGLILFALGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVFGFLFLATALLMLRPVLDPSLWLGLCGALLLIAAFCAWKQSEGFGRVAQLFGATSLLLGVWGSVLVIGAAGGSDDPYQPLQVYSAGRTVSAAPNGHEAFTTIKEPAALQRELDAAKAQGQWVLLDYYADWCVSCKVMEKQVFGQDKVMQGLSDVRLLRLDVTADNAASRELLGRYKVPGPPSFVWIGTDGEERRSQRITGEVDADTFLQRWTATRDAN
>CP027218.1|QAX86108.1|4518148_4519030_+|peroxiredoxin
MLTFTLGTFAIALNHLLLISALALATFVGWRVAKRGGDNPESALFSLFLLGMLAARIAFVGVYWSHYRNDPWQIIDLRDGGFLAWPGVIVLLLAALYRGWRRPGLRRPLGFGVVSGVAFWLLATLSLNIYEQGTRLPEISLRNAAGETIQLSDYQGGPLVINLWATWCPPCRREMPVLENAQQQRPDLTFLFVNQAESMQSVATFLETQGLSLNNVLFDRSGRLGQAVGSMALPTTLFYSPDGRLLSSHLGELSNASLARALENFGDPNSLSNPAANPATSARKLPCPASATC
>CP027218.1|QAX86109.1|4519005_4519776_+|thiol:disulfide-interchange-protein-DsbG
MPRLRHLLTLTLGTALLHLPSVQAAEELPAAIKQIEAKGAKIVGQFDAPDGLRGYAAQYQNRGMALYLTPDGKHVLLGNLYDADGKDLSSEPLQKLVYAPMAKEVWAKFEASNWIQDGNKDAPRTVYLFSDPNCPYCNMFWEQARPWVKSGKVQLRHIMVGIIREDSPGKSAALLAAKDPAKALEDHEKAGKASSLKALKDIPAAVQSKLGANMQLMEDLDLQATPAIFYMDAKGELQQQQGAPSPEKLAQILGPK
>CP027218.1|QAX86110.1|4519886_4520711_-|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase
MPFFTVDGQALHYIDQGTGPAVLLAGSYLWDQAMWAPQVAALSPHYRVIALDLWGHGESGRLPENTTSLDDIARQAQALLDHLDIDQVTLVGLSVGGMWGVRLALAAPQRINGLALMDTYVGVEPEPTRQYYFSLFKQIEDSGEISEQLLDIVVPIFFRPGIDSQSALYQDFRAKLAAYSSDRLRDSIVPMGRITFGRDDLLPRLGELNAATTLVLCGDQDKPRPPSEAQEMAELIGCPWVLVPQAGHISNLENPEFVTEVLFAFLSERNRHTE
>CP027218.1|QAX86111.1|4520903_4533902_-|non-ribosomal-peptide-synthetase
MTDAFEIPSTLVQALQRRAALTPDQLALRFLAENAEQAVVLSYRELDQRARTIAAALQAEAEYGDRAVLLFPSGPDYVAAFFGCLYAGVIAVPAYPPESARRHHQERLLSIIADAEPRLLLTSADLRDALQQIEGAPPLLCVDTLDSAQAENWVEPNLPQDHIAFLQYTSGSTALPKGVQVSHGNLVANEMLIRHGFGIDVNPDDVIVSWLPLYHDMGLIGGLLQPIFSGVPCILMSPAYFLGRPLRWLEAISQYGGTISGGPDFAYRLCSERVSESALERLDLSRWRVAYSGSEPIRLDTLERFAEKFAASGFSDDSFMASYGLAEATLFVAGTPRGTGIPALRVDDQALAQNRAEPGEGSPIMSCGISQPEHAVLIVEPNTLVELADNAIGEVWAAGPSIALGYWRNPEASAKTFVEHAGRTWLRTGDLGFIRDGELFVTGRLKDMLIVRGHNLYPQDIEKTVENEVEVVRKGRVAAFAVNQNGAEGIGIAAEISRSVQKILPPEALIKAIRQAVAEAYQEAPSVVVLLNPGALPKTSSGKLQRSSCRNRLADGSLDSYAVFPSTTSETQQATTSVSELEALIGKIWAEQLNVKQVNADDHFFLLGGNSIAATQVIARVREELALELNLRLLFEAPTLSAFAAAVAQQQQDGGSAQGAITALSRSEPMPQSLAQNRLWITWQLDPQSSAYNIPGALRLRGELDEDALRASFQQLIERHESLRTRFFERDGVALQQVDAAAEFNLQLIDISDLPAHEREARGQQIREDEARSQFDLEKGPLLWVTLVRLDDEDHQLLVTLHHIIADGWSLNILIDEFSRLYAAASQGATASLAPLPTQYADYGSWQRQWLAQGEGERQLAYWKNQLGDEHPALELATDYPRSAKQTHSAARHTVRLGVSLSDAIRNTAQAHQATPFMLLLSAFQSLLHRYSGQRDIRIGVPNANRPRLETQGLIGFFINTQVLRAKIDSRLSFVDLLGQTREAALGAQANQDLPFEQLLEAFPQAREQGLFQVMFNHQQRDLSALKRLPGLLAEELPWHSREAKFDLQLHSEEDRNGRLTLSFDYASELFDAATIERLCEHFSNLLRDVCERPQQAIGDLQLLTINEHDQQKNWSVAPCAPAQQWLPELLNEQARQTPERTALVWEGGSLDFAELHNQANRLAHYLRDKGVGPDVCVAIAAERSPQLLIGLLAIIKAGGAYVPLDPDYPAERLAYMLSDSGVELLLTQTELLDRLPASDGVSVIAMDALHLENWPSQAPGLHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQNAYALNETDVLMQKAPISFDVSVWECFWPLITGARLLIAGPGEHRDPHRIAQLVQEHGVTTLHFVPPLLSLFIDEPLSAECTSLRRVFSGGEALPAELRNRVLAQLPAVQLHNRYGPTETAINVTHWHCTTADGERSPIGRPLGNVICRVLDADLNPVPAGVPGELCISGIGLARGYLGRPALTAERFVVDPLGEQGARLYRTGDRARWTSDGVIEYLGRLDQQVKLRGFRVEPEEIEARLLAQDGVAQAVVLVRETAAGAQLIGYFTATDASVDADEQTTRLKTALAAELPEYMVPAQLMRLDAMPLSPSGKLDRRGLPEPQWQVREHVEPVTELQQQIAAIWREVLGLAQVGLRDDFFALGGHSLLATQIISRSRQACDVELPLRALFEHSELGDFAEQIRLIQVSGRTNKQPPIDKVDRSKPVPLSYSQQRMWFLWQMEPDSPAYNVGGMARLRGVLHVERFESALQALILRHETLRTTFPSVDGVARQQVHAETGVRMGWKDFSKFAADVREQKVQQLADEEAHLPFDLETGPLLRACLVKTAEHEHYFVLTLHHIVTEGWAMDIFARELSALYEAFVDDRDSPLEPLPVQYLDYSVWQRNWLESGERQRQLDYWTAQLGREHPLLELPGDRPRPPVQSHQGELFRFDLSDDLAARVRAFNAQNGLTLFMTMTAALATLLYRYSGQTDLRIGAPVANRIRPESEGLIGAFLNTQVLRCQLDGMMSVGELFEQMRHTVIEGQSHQDLPFDHLVETLQPPRSAAYNPLFQVMCNVQRWEFQQSRMLAGMTVEYLANDARATKFDLNLEVTDLDHRLGCCLTYSTDLFDEPTIARMARHWRNLLEALIADPQQRLSELPLLDSPEQQQLLDSLGIEPGEHRLDQCIHHLFAEQALARKDAPALTFAGQTLSYAELDAHANRLAWALRERGVGPQVRVGLALERSLEMVIGLLAILKAGGAYVPLDPEYPLDRLHYMIEDSRIGLLLSDRAMFNALGDLPSSVARWCLEDDSAALADYPASELPFISLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFGMRPDDCELHFYSINFDAATERLLVPLLSGAQVVLRAQGQWDAEEICGLIRSHKINVLGFTPSYGSQLAQFLSTQNEILPVRMIITGGEALTGEHLQRIRATFKPAMFFNAYGPTETVVMPLASLAPEVLEEGAGSVPIGSVIGARVAYILDADLALVPQGATGELFVGGAGLAQAYHDRPGITAERFIADPFATDGGRMYRTGDLVRQRADGLVEYLGRIDHQVKIRGFRIELGEIETRLLDHDSIREAVVLALDAPSGKQLVGYLVTEVAEQSEAKQAELRDALKSQLKAQLPDYMVPTHLILLASMPLTDNGKLDRRALPAPNPEANRQDYVAPSNELEQTLAQIWCAVLNVEQVGLNDNFFELGGDSILSIQVVSRARQQGIHFSPRDLFQHQTVQTLAAVASRTEQVTAEQGLVVGESPLTPIQHWFFDTDIPERQHWNQALLLEPTVALEPHRLEQALLAVIEQHDALRLRFTESDSRWQASHQPVSDAAVLWQVRVPSMDKCAALFADAQRSLDLAQGPLLRGVLVDGPHGQQRLFIAIHHLVVDGVSWRVLLDDLQTVYRQLDAEQAVKLPAKTSAFKDWAARLQAYAGSESLREELDWWQTQLAGPNADLPCENPQGGQQNRHAQTVNVRLDAEHTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQPSALIQLEGHGRETLFDEIDLTRTVGWFTSAYPLRLTPHNIEEAAGQGASIKAIKEQLRAVPHKGLGYGVLRYLADDLSQRSMAALPQAPITFNYLGQFDQSFGSDALFRPLDEPVGAAHDPQAPLPNELSVDSQVYGGELLLRWTFSAERYDAQTINDLADAYLGELQSLIDHCLQDDAGGLTPSDFPLAKLTQAQLDALPVPAAHIEDVYPLTPMQEGMLLHTLLEPGTGLYYMQDRYRINSELDAERFAQAWQAVIARHEALRASFCWNVGEDMLQVIHTPGRTPIEYLDWSAIAETEQEPKLQALLKNERKAGFDLLNQAPFHLRLIKVGAARYWFMMSNHHILIDAWCRSLLMNDFFEIYTALGEGREAQLAVPPRYRDYIGWLQRQSLDEARQWWQSNLQGFERTTPIPSDRPFLREHAGESGGMIVGDRYTRLNVEDGARLRELAQAHQLTINTFAQAAWALVLRRMSGDRDVLFGVTVAGRPVEMPEMQRTVGLFINSIALRVQMPADDQRSSVRQWLSGLLDSNMQLREYEYLPLVNIQEQSELPKGQPLFDSLFVFENAPVEVSVLDRAQSLNATSDSGRTHTNFPLTAVCYPGDDLGLHLSYDQRYFDESTIERMLGEFKRLLLALVDGFHGDMADLPLLGTEEQDFLLHGCNQSGHDYPLEQSYVALFEAQVTAHPQRIAATCLDQQQSYAELNHNANRLGHALVAAGVQMDQPVALLGERNLDLLGMIIGSFKAGAGYLPLDPGLPSQRLQRIIELSRTPVLVCSKACFEQAQTLLDEFSCANRPKLLVWEEIQAAATSAQDLGIYSAPDNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVPYLNLSDADVIAQTASQSFDISVWQFLAAPLFGARVDIVPNTIAHDPQGLLVHVQAQGITVLESVPSLIQGMLASERLSLDGLRWMLPTGEAMPPELAHQWLLRYPDIGLVNAYGPAECSDDVAFFRVDMASTRGSYLPIGTPTDNNLLYLVDGALELVPLGAVGELCVAGTGVGRGYVSDPLRTAPVFVPNPFGAPGERLYRTGDLARRRSDGVLEYVGRVDHQVKIRGYRIELGEIEARLHEQPEVRDGAVGVQEGVNGKHLVGYLVAADSALNPSERLERIKQRLRAELPEYMVPLHWLWLDQLPLNANGKLDRKALPALEIGQLQSQDYLAPRNELEQTLADIWAEVLKVEQVGVRDNFFELGGHSLLATQIASRVQKSLQRDVPLRAMFECSTVEELAEYIDGLAASDITEEKVDRLNDLMAELEGL
>CP027218.1|QAX86112.1|4534273_4534828_+|RNA-polymerase-factor-sigma-70
MTEQVSTSRCDSPLLQAFVDNRLILVKIAARITGCRSRAEDVVQDAFFRLQSAPPITSSIKAQLSYLFQIVRNLAIDHYRKQALEQKYSGPEEEGLNVVIQGASPETSHINFSTLEHIADALTELPSRTRYAFEMYRLHGVPQKDIAKELGVSPTLVNFMIRDALVHCRKVSGSRRDAVIAGRR
>CP027218.1|QAX86113.1|4534921_4535935_-|GNAT-family-N-acetyltransferase
MSNLNELTALALPSGSQLIADATESRLSLSLDGQPLIRLRLDREAKGPIQIDERFALPPGQALWAACYWLFARDPDCQQLTWQLDQPPTEALLSGLLVSTEVAGEYCCERTLFWQLPQPWLGTSLTGSYPQQMVISQGKRHPLRPVKPRGEVYRRFDARLGAWISLRTVEIEEDLPRFNRWQNSPRVASFWQEEGSIEKHREYLSKLDTDPHTLTLIGCFDDQPFAYFEAYWAKEDRIAPFYDADNFDRGIHMLVGEEDHRGPHKVASWLSALVHYLFLDDPRTQRVVAEPRADNAKMIGHMQNQCFHCEKEFDFPHKRAALMILGRERFFDRCKLA
>CP027218.1|QAX86114.1|4536022_4536820_-|amino-acid-ABC-transporter-substrate-binding-protein
MKSSPIRTAAGLMLAALAAIWVLPAQAAQLVRVGAAHFPPYTVRPENGADTGLLPQLVEALNAQQSDYQFVLVPTSIPRRFGDFKQGRIDMAIFENPEWGWKDIPHTDVDMGLEDAEIFVAQREDGRQQNYFASLTGKRLALFSGYHYEFASFNADPKFLAQNFNATLTYSHDSNLLMVLRGRADIALVTRSYLFDYLLRNEKVRDELLVSQRIDQVYHHYAILRPTAPITGEAFSRLLQGLRDNGEMLKIFDPYKIAVVPVPHH

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Crispr_ID: CP027218_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027218_6

4936849-4936947

Orphan

Consensus_repeat	Method
ATTGATTTTGTGTGCGACTCGGACACTGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027218_6

>merge|CP027218|6|4936849-4936947|CRISPRCasFinder
ATTGATTTTGTGTGCGACTCGGACACTGTGGAGCTGGCTTGCCTGCCCCCACAAATACCGAGGTGTTCATTGATTTTGTGTGCGACTCGGACACTGTGG

>CP027218|6|6|4936849-4936947|CRISPRCasFinder
ATTGATTTTGTGTGCGACTCGGACACTGTGG	AGCTGGCTTGCCTGCCCCCACAAATACCGAGGTGTTC
ATTGATTTTGTGTGCGACTCGGACACTGTGG

Protein	Signature genes	Signature genes Name	Protein_function
CP027218.1\|QAX86483.1\|4943634_4944297_-\|lysine-transporter-LysE	unknown	unknown	gnl\|CDD\|280058
CP027218.1\|QAX86465.1\|4927513_4927819_+\|peptidase-M4	unknown	unknown	gnl\|CDD\|225753
CP027218.1\|QAX86474.1\|4936970_4937825_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP027218.1\|QAX86471.1\|4934543_4935302_+\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|187620
CP027218.1\|QAX86478.1\|4940458_4940884_-\|DUF4440-domain-containing-protein	unknown	unknown	gnl\|CDD\|226769
CP027218.1\|QAX86469.1\|4931803_4933417_+\|anion-permease	unknown	unknown	gnl\|CDD\|223383
CP027218.1\|QAX86466.1\|4928121_4928568_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372297
CP027218.1\|QAX86477.1\|4940073_4940418_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|226318
CP027218.1\|QAX86476.1\|4938839_4940081_-\|RNA-polymerase-subunit-sigma-24	unknown	unknown	gnl\|CDD\|227277
CP027218.1\|QAX86472.1\|4935417_4935855_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226610
CP027218.1\|QAX86464.1\|4926223_4927351_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
CP027218.1\|QAX86482.1\|4943069_4943567_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226231
CP027218.1\|QAX86480.1\|4941527_4942133_+\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|274926
CP027218.1\|QAX86473.1\|4935943_4936798_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP027218.1\|QAX86479.1\|4941023_4941509_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP027218.1\|QAX86470.1\|4933524_4934421_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176161
CP027218.1\|QAX86467.1\|4928678_4930301_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
CP027218.1\|QAX86475.1\|4937936_4938662_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|226674
CP027218.1\|QAX86481.1\|4942269_4942758_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP027218.1\|QAX86468.1\|4930579_4931602_+\|magnesium-transporter-CorA	unknown	unknown	gnl\|CDD\|213368

Protein	Function_ID	Function_description	E-value
CP027218.1\|QAX86483.1\|4943634_4944297_-\|lysine-transporter-LysE	gnl\|CDD\|280058	pfam01810, LysE, LysE type translocator. This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.	2.59192e-17
CP027218.1\|QAX86465.1\|4927513_4927819_+\|peptidase-M4	gnl\|CDD\|225753	COG3212, COG3212, Predicted membrane protein [Function unknown].	2.28361e-11
CP027218.1\|QAX86474.1\|4936970_4937825_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.19231e-33
CP027218.1\|QAX86471.1\|4934543_4935302_+\|short-chain-dehydrogenase	gnl\|CDD\|187620	cd05362, THN_reductase-like_SDR_c, tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs. 1,3,6,8-tetrahydroxynaphthalene reductase (4HNR) of Magnaporthe grisea and the related 1,3,8-trihydroxynaphthalene reductase (3HNR) are typical members of the SDR family containing the canonical glycine rich NAD(P)-binding site and active site tetrad, and function in fungal melanin biosynthesis. This subgroup also includes an SDR from Norway spruce that may function to protect against both biotic and abitoic stress. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.34628e-68
CP027218.1\|QAX86478.1\|4940458_4940884_-\|DUF4440-domain-containing-protein	gnl\|CDD\|226769	COG4319, COG4319, Ketosteroid isomerase homolog [Function unknown].	9.64441e-29
CP027218.1\|QAX86469.1\|4931803_4933417_+\|anion-permease	gnl\|CDD\|223383	COG0306, PitA, Phosphate/sulphate permeases [Inorganic ion transport and metabolism].	5.77678e-58
CP027218.1\|QAX86466.1\|4928121_4928568_-\|hypothetical-protein	gnl\|CDD\|372297	pfam12761, End3, Actin cytoskeleton-regulatory complex protein END3. Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release. End3p is part of the coat module protein complex Pan1, along with Pan1p, Sla1p, and Sla2p. The proteins in this complex are regulated by phosphorylation events. End3p also regulates the cortical actin cytoskeleton. The subunits of the Pan1 complex are homologous to mammalian intersectin.	0.000792604
CP027218.1\|QAX86477.1\|4940073_4940418_-\|YciI-family-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	8.56475e-38
CP027218.1\|QAX86476.1\|4938839_4940081_-\|RNA-polymerase-subunit-sigma-24	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	3.2354e-172
CP027218.1\|QAX86472.1\|4935417_4935855_-\|hypothetical-protein	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	1.41836e-52
CP027218.1\|QAX86464.1\|4926223_4927351_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	1.96924e-107
CP027218.1\|QAX86482.1\|4943069_4943567_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|226231	COG3708, COG3708, Uncharacterized protein conserved in bacteria [Function unknown].	6.8815e-30
CP027218.1\|QAX86480.1\|4941527_4942133_+\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|274926	TIGR04025, hypothetical_protein, PPOX class probable FMN-dependent enzyme, DR_2398 family. Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.	4.34066e-109
CP027218.1\|QAX86473.1\|4935943_4936798_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.61101e-39
CP027218.1\|QAX86479.1\|4941023_4941509_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.94652e-11
CP027218.1\|QAX86470.1\|4933524_4934421_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176161	cd08472, PBP2_CrgA_like_3, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 3. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.66789e-98
CP027218.1\|QAX86467.1\|4928678_4930301_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.04484e-68
CP027218.1\|QAX86475.1\|4937936_4938662_+\|oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.48306e-99
CP027218.1\|QAX86481.1\|4942269_4942758_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.70245e-12
CP027218.1\|QAX86468.1\|4930579_4931602_+\|magnesium-transporter-CorA	gnl\|CDD\|213368	cd12834, ZntB_u1, Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily. The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.37551e-126

>CP027218.1|QAX86473.1|4935943_4936798_+|LysR-family-transcriptional-regulator
MISQEVLLAFVQAATQGSFSAAARKLGRSQSTISAAVASMEIDLDLVLFDRSSRKPTLTPAGHVMLQRAEAILAASSRLEMTARQLSQGVEPKLTVAISDTYQSYRFEAALAGFEQRYPDLELECLIAECEDLIELVQRGRAHLAFAEMQENYPPDLVTSTVAERTEIALFVNRDHALAKLEHVDQHILEQHRELRLATIVNPYDSRGKGRVWSAPSYLMLLEMAEKGFGWAPLPRWLAQRFGNDLLVELKVRGWPKPVFVDALWSRLYPPGPAGSWLLSKMLE
>CP027218.1|QAX86472.1|4935417_4935855_-|hypothetical-protein
MTTNKSITERIFQAVGFELLAILICTPLLAWLMKKPMLEMGAVTVLIALLALGWNVVFNRYFDRMLARMNIAHSAWVRVLHALLFEGGLIVMGVPLIAWWLSVSLWQAFLLDIGVLLFFLPYTYVYHWGYDVLRERFTTRRACQN
>CP027218.1|QAX86471.1|4934543_4935302_+|short-chain-dehydrogenase
MNRKIALITGASRGLGKNAALHLAAQGVDIIGTYHSRADEAQALVLELEKLGAKAVMLQLDVGRSESFADFGTRVEQALQQIFERQRFDFLINNAGVGLHVSFAETSVEQFDMLMNVHFKGPFFLTQQLLPLINDGGRIINISSGLARFTIPGASAYAAMKGAIEVLTRYQAKELGARQIAVNTLAPGAIETDFGGGTVRDNAAVNAMVADNTALGRAGQPDDIGGALALLLSPGAQWINGQRVEASGGMFL
>CP027218.1|QAX86470.1|4933524_4934421_-|LysR-family-transcriptional-regulator
MNKLELLRTFVRVSELSSFTLAGENLGLPRSTVSEHVQALEALLGTRLLQRTTRKVQATQDGLVLYERSKDLLSHMDEIEGLFRQDEASLTGRIRVDLPNILARRLVMPSLPQFMDRHPNLELEISSTDRRVDLLSEGFDCVVRIGAQPDQSVVARHLGDFPMVNCASPAYLARYGVPQTLEDLAQHRLVHYVGVLGSRSEGFVYEEGGQVKRLPMAGSVTVNSTDAYESACLGGFGLTQVPRTGMQPHLDNGELVTVLPQFTAPAMGISLLYARQRHLPLRVRVFMDWLGDLIRCAL
>CP027218.1|QAX86469.1|4931803_4933417_+|anion-permease
MATPSLTASPASAASGRPALDKKTGPFTYVIFFAVLAMGMLFTAYSLMHDMHELGTVVTTWTPFLLLGVALLIALGFEFVNGFHDTANAVATVIYTHSLPPNVAVVWSGFFNFLGVLLSSGAVAFGIIALLPVELILQVGSSAGFAMIFALLIAAILWNLGTWWLGLPASSSHTLIGSIIGVGVANALMHGRDGTSGVDWAQATKIGYALLLSPLVGFGCAALLLLALRAFVKNRSLYKAPEGNAPPPWWIRGLLIATCTGVSFAHGSNDGQKGMGLIMLILVGTLPMAYALNRTMPEEQSLQFAAVAQVTQQALVKSAPLPTPADPRAVLSDYVRSKEATPQLIPALAALTGHIGEEVKGYGSLAKVPAEAMGNVRNDMYLASESIRLMDKNKVGNFDADTSGKLQLFKQQIDNATRFIPLWVKIAVAIALGLGTMVGWKRIVVTVGEKIGKTHLTYAQGASAETVAMLTIGAADMFGLPVSTTHVLSSGVAGTMVANGGGLQMKTIRNLLMAWVLTLPAAILLSGSLYWLFTQIF
>CP027218.1|QAX86468.1|4930579_4931602_+|magnesium-transporter-CorA
MNHSLDISHRDPDLFGLLYGFRFLPGERGREVDSATALRCLQDDNDSGEFLWLHLNLAHAACERWMKSHLQLPEEFFEALHEGSRSTRIEHVDSALLAVVNDVVFNLSSMVSSDVSTLWVCVRSKLIVSARLQPLHSVDKLRSSVKAGERFRSPSELLVHLLRDQGEVLTQIVRKTSLSVDQVEDQLLSSRLSTNRAELGANRRVLVRLQRLLALEPGSLLRLLNRPPPWLQKEDVKELRKSTEEFALIINDLTALGERIKLLQEEIAANLNEQSNRTLFTLTVVTVLALPINIIAGFFGMNVGGVPLSQDPEGFWILVALVATFTVIAGRWAFRKRGDY
>CP027218.1|QAX86467.1|4928678_4930301_-|methyl-accepting-chemotaxis-protein
MLQKSLRAQILALLSGSLLAMLLIALACFHFLSNGVQSYSQLIAGPLHTSQLIDEANLQFKVQVQEWKNVLLRGKQPADLAKYWSQFEDRQRDVQNILGELASQKGIEPSLKSRIERLRDEHRQLGSAYQKGRDAYVAAGGDPTAGDNAVKGVDRATSDQMSELVSELRKQGNDQSLLISAEADRTVLFGLLVMLASGLLIGLLSLWLVNRNLVEPIRKLIDYVTQLSRGKLAERVVSDRQDELGNLAAAANTLRDFLADTFTRLQRSASDLDSASGELNAIATTMAGGTNEQFNRTDQVATAMNEMSATAQEVARHAADAARAADDADQSAQQGEKVMQSTIHSITQMRGEIANTATVIRRLEADSGRIGKVLEVIRGIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLAQRTAESIIEINQIIQSVQTGAVDAAQAIDSGQTRSDESVEQVTQAGAMLERITHAVEAIRDMNRQIATAAEEQTSVAEDISRNLTEITSIASTNLDNVQRTESASQNLHGLSGQLNEVTARLSA
>CP027218.1|QAX86466.1|4928121_4928568_-|hypothetical-protein
MVSITSVSINQTVTAPTSKTLITDVGDDTSTSSTASTGSTADSSKVAAGGGAAPAGDSSSSSSEESDSVKELRKQIAELQKQLQEQQQALQAAQAKQESSDAKAAEVAAAQAQITATSASLSTATASLLQALQDSDSSTSGSLVSTSV
>CP027218.1|QAX86465.1|4927513_4927819_+|peptidase-M4
MKTLTALFTAAALTLTAGLAQADIRVDQIPQLVKEGKIKSLESMNAEALKLHPGATITDTDLDNHFNGYEYEVELKTADGKEFDVDFDATTGKVLSNKQDT
>CP027218.1|QAX86464.1|4926223_4927351_+|glycerophosphodiester-phosphodiesterase
MSATFTKSALMLSLLLGLGQAHAATHSDPDAVAAAHGIPHPAVIAHRGASFDAPESTAASYKLARDLGADYLEMDLQRSKDGVLFALHDNNLQRTTDVATKFPDRKDSPANAFTMAELKTLDAGSWYNTAYPDRARPTYAGLKILTLDEIIDIAQANPQHKPGLYIETKEPQLFPGIEKDLKNKLQDRGWLSPAGSKLAKSALGVGQGKGKVILQTFEKNSLELLQKEMPQVPKILLLWVGEGSIEPKSKVTFAESGEKDKNVFYGKQEPKSEAEFKQWIDYAKAQGAIGTGPSAKLTHDGDQSYSDLVQPWMNKYTHDQGMLVHVYTVDEPVDFEKVMAAGVDGIFTNRASELLKFYKRPAAASVDQVLKNNGF
>CP027218.1|QAX86474.1|4936970_4937825_-|LysR-family-transcriptional-regulator
MDIRHLKAFLAVFEERNITAAAQRLFISQPTLSVTIKQLEEELGATLFVRLPRGVEVSDEARLLYPQARRMVAEAEALSRMFRGRENRVPLTLGIEGDIAASHIEAFVRMAHLALPNLLLTLEEGCHGEGRLAVEEMCCEDELFLPLWEESYVMALPVNHPMAAVQANWAPIEDWITCPQQPSHQRLMALYGRSPEAVAGHAGSLQQALHMVAAGLGVAMLPQSLVSGHARVVVRALHLPAPTRRVGLCYAAQALEMPAMRGLHEYFLQKSTGGDRSGLMGCLG
>CP027218.1|QAX86475.1|4937936_4938662_+|oxidoreductase
MSKPLIIITGASSGIGAATARRLSAAGHPLLLLARRIERLEALELPNTLSREVDITDRATLLAAVAEAEAQFGPADALINNAGVMLLGAMSEQDPAQWDRMLDVNVKGLLNGVHAVVAGMIERKRGTIINVSSVAGRKTFPNHVAYVGTKFAVHGLSENLREELAPHNVRVTTIAPGAVETELLSHTTDEAIKTGYQAWKQDMGGTVLSAEDVATAIEYAYGQPQGVCIREIVMAATRQQA
>CP027218.1|QAX86476.1|4938839_4940081_-|RNA-polymerase-subunit-sigma-24
MSEVRARVEQVYREDSRRILATLIRLLGDFDLAEEALHEAFFIAVERWQRDGVPDNPRTWLVSTGRFKAIDVLRRRARFKASQPLLLAQLEELEQADWSGEDVEDDRLRLIFTCCHPALAADAQVPLTLREVCDLTTEEIARAFLSAPAAIAQRIVRAKAKIRDAKIPYQVPSLSELPERLDSVLRVIYLVFNEGYSASVGAELTREDLTREAIRLGRLLMELLPEPEVMGLLAMMLLHESRRSARTSPDGELVLLDDQDRSLWDSELIAEGCALVERALTTRRFGPYCLQAAIAAVHAEAPSAAETDWEQIVGLYDVLLRAVPSPVIELNRAVAVAKRDGALAGLALIEGILDRGELQDYHLAHSARAEFCRQLGRVAEARAAYLRALELTRQEPERRFIEGRLLALKLPSP
>CP027218.1|QAX86477.1|4940073_4940418_-|YciI-family-protein
MKYLCLVYSDERLLHSSPDSPEDAECWAYAESIQGSGRMVAAEALESVQTATTVRMRNGKLSITDGPFAETKEQLAGFYLIDAKDLNEAIQVAGNIPAARVGSVEVRPVRQLNV
>CP027218.1|QAX86478.1|4940458_4940884_-|DUF4440-domain-containing-protein
MSAHTEIQTLINTYREAVMKKDVEKVMALYADDIVSFDAIKALQFKGKTAYREHWVACMEMCPGPHIFEFHEIAIESADNIAFAHWVANCGGTNDKGETQSCWMRVTACYRQVGGTWKIAHEHWSAPFDPMSGATLFDVTP
>CP027218.1|QAX86479.1|4941023_4941509_+|GNAT-family-N-acetyltransferase
MSAQLVPYDSLNTLQREQVEAIEIHAEQIKFSGDIHGALHTLLSKPGPGVKGFALLADEVPVAFLLLKRPPVLPAWADEHSATLHALQVDRRAQGKGYGKACLQALPEVARQAWPEIKGLELSVDADNDAAIALYAKHGYVDSGEAYKGRIGYERRMGLFF
>CP027218.1|QAX86480.1|4941527_4942133_+|pyridoxamine-5'-phosphate-oxidase
MIDSIEALEAIYGLPHDRAVRKQIGFLNEDYQAMVRVSPLVIVSSVGADGLDNSPRGDAPGFVRIIDQNTLALPDRPGNNRIDTLRNVLQDSRVSLLFIIPGIGETLRVNGTATISADPQLLESFAVNGKPAKTVLLVTVEAAFFHCSKAFVRSDAWNPETHLPRSALPSAGAFHKRLNDGEFDADTYDREAPKRVTDTLY
>CP027218.1|QAX86481.1|4942269_4942758_-|GNAT-family-N-acetyltransferase
MNTIIRNVTAADLDRCYAIETVAYEGDEAATHEKIAKRIATWPEGFIVAEVDGVVAGFVNSGAAFDVQMSDEAFKELIGHDPKGPNVVIMSVVVHPDYQGQGLAKRLMAEFIERMRGMDKATIHLMCKEIHIPLYAGFGFAYIKPSESDHGGMAWHEMILTL
>CP027218.1|QAX86482.1|4943069_4943567_-|AraC-family-transcriptional-regulator
MDEQTRVEVAEPRFEHGHFLLIAGFRGRFTQDTAKDIPALWEKFLPHLGKIQGQKNEVTYGVCSNFDGKGGFDYIAGVEISKLDDLDQKVYQWVEVLPRQYAVFEHKGPLDQLPQTLQYIYKTWLPTSHYVELNAPELERYSADFNPRLHTGKLEICVPVDTRQA
>CP027218.1|QAX86483.1|4943634_4944297_-|lysine-transporter-LysE
MEFTSGFLLSLSLCLDIGVANIAMITLAMQRGYFQGFALGLGTCVGDLIYAVLALAGMTVLLQYESVRWVLWIGGSALLIYFAAKMIYSAIHHEAQLAATPEVGQNSHRKEFFRGIFLAMSSPSAILWFAAVGGTLIARSGGGGPLSSALFLGGFLCAGLLWSAGLCFAASHGGKLLGDKLLRYSYMASAAIFCYFAVYVIVSGYNEFVGSGAVEQLHAL

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1560856 : 1674592

116

Pseudomonas_phage(40.0%)

tail,lysis,plate,tRNA,holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAX83610.1\|1560856_1561675_+\|tRNA	tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA	S4VW33	Pandoravirus	3.5e-09	28.0
QAX83611.1\|1561815_1562226_-	Fe-S metabolism protein SufE	NA	NA	NA	NA
QAX83612.1\|1562222_1563428_-	cysteine desulfurase CsdA	Q2XUY6	environmental_halophage	7.5e-69	36.1
QAX83613.1\|1563559_1564594_-	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	NA	NA	NA	NA
QAX83614.1\|1564627_1565065_-	ArsC family reductase	NA	NA	NA	NA
QAX83615.1\|1565283_1566915_+	Na+/H+ antiporter	NA	NA	NA	NA
QAX83616.1\|1566946_1567684_-	hypothetical protein	NA	NA	NA	NA
QAX83617.1\|1567717_1568452_-	hypothetical protein	NA	NA	NA	NA
QAX83618.1\|1568641_1569838_-	succinyldiaminopimelate transaminase	NA	NA	NA	NA
QAX83619.1\|1569881_1572584_-	[protein-PII] uridylyltransferase	NA	NA	NA	NA
QAX83620.1\|1572625_1573408_-	type I methionyl aminopeptidase	NA	NA	NA	NA
QAX83621.1\|1573781_1574519_+	30S ribosomal protein S2	NA	NA	NA	NA
QAX83622.1\|1574711_1575575_+	elongation factor Ts	NA	NA	NA	NA
QAX83623.1\|1575784_1576528_+	UMP kinase	NA	NA	NA	NA
QAX83624.1\|1576524_1577082_+	ribosome recycling factor	NA	NA	NA	NA
QAX83625.1\|1577096_1577852_+	di-trans,poly-cis-decaprenylcistransferase	R9W0U9	Flavobacterium_phage	8.5e-18	38.1
QAX83626.1\|1577851_1578658_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
QAX83627.1\|1578654_1579845_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
QAX83628.1\|1579899_1581252_+	zinc metallopeptidase RseP	NA	NA	NA	NA
QAX83629.1\|1581326_1583702_+	outer membrane protein assembly factor BamA	NA	NA	NA	NA
QAX83630.1\|1583747_1584251_+	hypothetical protein	NA	NA	NA	NA
QAX83631.1\|1584254_1585310_+	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	NA	NA	NA	NA
QAX83632.1\|1585416_1585857_+	beta-hydroxyacyl-ACP dehydratase	NA	NA	NA	NA
QAX83633.1\|1585853_1586630_+	acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase	NA	NA	NA	NA
QAX83634.1\|1586632_1587760_+	lipid-A-disaccharide synthase	NA	NA	NA	NA
QAX83635.1\|1587774_1588401_+	ribonuclease HII	V5LS49	Emiliania_huxleyi_virus	3.7e-27	38.9
QAX83636.1\|1588477_1591999_+	DNA polymerase III subunit alpha	A0A2L1IZ23	Streptomyces_phage	8.6e-198	37.0
QAX83637.1\|1592138_1593086_+	acetyl-CoA carboxylase carboxyl transferase subunit alpha	NA	NA	NA	NA
QAX83638.1\|1593194_1594523_+\|tRNA	tRNA lysidine(34) synthetase TilS	M1I5D7	Paramecium_bursaria_Chlorella_virus	4.5e-06	24.5
QAX83639.1\|1594797_1596429_+	CTP synthetase	A0A1J0FA14	Only_Syngen_Nebraska_virus	4.5e-157	52.9
QAX83640.1\|1596433_1597279_+	3-deoxy-8-phosphooctulonate synthase	E3T537	Cafeteria_roenbergensis_virus	1.6e-49	42.8
QAX83641.1\|1597435_1598725_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	4.8e-138	59.7
QAX83642.1\|1598896_1599175_+	cell division protein FtsB	NA	NA	NA	NA
QAX83643.1\|1599171_1599879_+	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
QAX83644.1\|1600022_1600919_-	LysR family transcriptional regulator	NA	NA	NA	NA
QAX83645.1\|1601035_1602148_+	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	E3SJ82	Synechococcus_phage	1.6e-33	30.1
QAX83646.1\|1602243_1603089_+	S-formylglutathione hydrolase	NA	NA	NA	NA
QAX83647.1\|1603133_1603607_+	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
QAX83648.1\|1603603_1604662_+\|tRNA	tRNA pseudouridine(13) synthase TruD	NA	NA	NA	NA
QAX83649.1\|1604649_1605399_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	3.7e-66	52.2
QAX83650.1\|1605398_1606076_+	protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	4.0e-43	49.8
QAX83651.1\|1606286_1607156_+	peptigoglycan-binding protein LysM	A0A0S2SXL7	Bacillus_phage	6.5e-06	33.3
QAX83652.1\|1607262_1608273_+	RNA polymerase sigma factor RpoS	G8CLC7	Synechococcus_phage	6.6e-34	35.8
QAX83653.1\|1608814_1609138_-	ferredoxin family protein	NA	NA	NA	NA
QAX83654.1\|1609301_1611884_-	DNA mismatch repair protein MutS	A0A1V0SDQ0	Indivirus	1.6e-28	23.8
QAX83655.1\|1612123_1612873_+	DNA-binding protein	NA	NA	NA	NA
QAX83656.1\|1612839_1613331_+	hypothetical protein	NA	NA	NA	NA
QAX83657.1\|1613880_1614261_+	DUF1090 domain-containing protein	NA	NA	NA	NA
QAX83658.1\|1614253_1614865_+	hypothetical protein	NA	NA	NA	NA
QAX83659.1\|1614917_1615100_+	hypothetical protein	NA	NA	NA	NA
QAX83660.1\|1615238_1615973_+	transcriptional regulator	B5TK58	Pseudomonas_phage	1.7e-127	91.8
QAX83661.1\|1616522_1616969_+	hypothetical protein	NA	NA	NA	NA
QAX83662.1\|1617100_1617517_+\|tail	tail assembly chaperone	NA	NA	NA	NA
QAX83663.1\|1617691_1618120_+\|tail	phage tail protein	NA	NA	NA	NA
QAX83664.1\|1618242_1618581_+\|holin	pyocin R2, holin	B5TK61	Pseudomonas_phage	2.2e-50	86.6
QAX83665.1\|1618651_1619164_+	hypothetical protein	NA	NA	NA	NA
QAX83666.1\|1619167_1619776_+\|plate	phage baseplate assembly protein V	A0A2H4JBW8	uncultured_Caudovirales_phage	6.1e-43	52.4
QAX83667.1\|1619790_1620123_+\|plate	phage baseplate protein	A0A2H4JI46	uncultured_Caudovirales_phage	7.9e-37	69.1
QAX83668.1\|1620119_1621115_+\|plate	baseplate J protein	A0A2H4JC04	uncultured_Caudovirales_phage	6.6e-111	63.8
QAX83669.1\|1621111_1621747_+\|tail	phage tail protein I	A0A2H4JDK0	uncultured_Caudovirales_phage	9.9e-44	52.9
QAX83670.1\|1621747_1624195_+\|tail	phage tail protein	A0A077K818	Ralstonia_phage	1.2e-86	38.1
QAX83671.1\|1624210_1624639_+\|tail	phage tail protein	Q9ZXK5	Pseudomonas_virus	7.9e-21	44.9
QAX83672.1\|1624740_1624926_+	hypothetical protein	NA	NA	NA	NA
QAX83673.1\|1624928_1626095_+\|tail	phage tail protein	B0ZSG8	Halomonas_phage	8.5e-126	57.0
QAX83674.1\|1626094_1626601_+\|tail	phage tail protein	Q6R4W3	Vibrio_virus	1.8e-24	36.3
QAX83675.1\|1626783_1627365_+\|tail	phage tail assembly protein	B0ZSH0	Halomonas_phage	5.0e-26	35.4
QAX83676.1\|1627494_1629474_+\|tail	phage tail tape measure protein	NA	NA	NA	NA
QAX83677.1\|1629470_1629854_+	hypothetical protein	A0A2H4JAC8	uncultured_Caudovirales_phage	2.1e-33	52.8
QAX83678.1\|1629846_1630059_+\|tail	phage tail protein	A0A2H4JGD9	uncultured_Caudovirales_phage	4.4e-17	61.4
QAX83679.1\|1630068_1631100_+\|tail	phage tail protein	B0ZSH3	Halomonas_phage	7.6e-94	51.1
QAX83680.1\|1631272_1631857_+	hypothetical protein	B5TK65	Pseudomonas_phage	1.2e-83	78.4
QAX83681.1\|1631853_1632036_+	DUF2635 domain-containing protein	B5TK66	Pseudomonas_phage	2.7e-23	88.3
QAX83682.1\|1632035_1633532_+\|tail	phage tail protein	B5TK67	Pseudomonas_phage	1.4e-261	91.8
QAX83683.1\|1633599_1633947_+\|tail	phage tail protein	B5TK68	Pseudomonas_phage	3.8e-58	93.9
QAX83684.1\|1633943_1634240_+\|tail	phage tail assembly protein	B5TK69	Pseudomonas_phage	2.8e-41	90.8
QAX83685.1\|1634370_1635951_+\|tail	phage tail protein	B5TK70	Pseudomonas_phage	3.3e-88	65.6
QAX83686.1\|1635937_1637173_+	hydroxyacid dehydrogenase	B5TK71	Pseudomonas_phage	2.2e-156	66.5
QAX83687.1\|1637176_1638223_+\|plate	baseplate protein	B5TK72	Pseudomonas_phage	3.4e-158	80.6
QAX83688.1\|1638337_1638847_+\|plate	phage baseplate assembly protein V	B5TK73	Pseudomonas_phage	2.4e-77	85.2
QAX83689.1\|1638846_1639245_+	hypothetical protein	B5TK74	Pseudomonas_phage	1.8e-67	93.2
QAX83690.1\|1639234_1640275_+\|plate	baseplate J protein	B5TK75	Pseudomonas_phage	2.3e-154	80.6
QAX83691.1\|1640265_1640865_+	DUF2313 domain-containing protein	B5TK76	Pseudomonas_phage	2.3e-103	89.4
QAX83692.1\|1641816_1642206_+	hypothetical protein	A0A291LAV4	Bordetella_phage	1.1e-08	41.6
QAX83693.1\|1642348_1643386_+\|tail	phage tail protein	B5TK79	Pseudomonas_phage	3.6e-112	58.1
QAX83694.1\|1643429_1644014_+\|tail	phage tail protein	B5TK80	Pseudomonas_phage	1.8e-39	40.7
QAX83695.1\|1644096_1645020_+	hypothetical protein	B5TK77	Pseudomonas_phage	1.7e-20	72.7
QAX83696.1\|1645019_1645487_+	hypothetical protein	NA	NA	NA	NA
QAX83697.1\|1645526_1646453_+\|tail	phage tail protein	B5TK81	Pseudomonas_phage	1.3e-33	37.8
QAX83698.1\|1646455_1646896_+	hypothetical protein	Q9ZXK5	Pseudomonas_virus	1.7e-18	41.3
QAX83699.1\|1646938_1648141_+	carbohydrate-binding protein CenC	B5TK77	Pseudomonas_phage	1.1e-19	68.7
QAX83700.1\|1648150_1648369_+	hypothetical protein	NA	NA	NA	NA
QAX83701.1\|1648405_1648972_+	lysozyme	B5TK83	Pseudomonas_phage	8.4e-87	83.2
QAX83702.1\|1648950_1649469_+\|lysis	lysis protein	B5TK84	Pseudomonas_phage	4.8e-57	72.9
QAX83703.1\|1649536_1650037_+	damage-inducible protein CinA	B5TK85	Pseudomonas_phage	9.4e-74	88.0
QAX83704.1\|1650120_1651182_+	recombinase RecA	A0A0S2MVG1	Bacillus_phage	7.8e-110	61.8
QAX83705.1\|1651190_1651661_+	recombination regulator RecX	NA	NA	NA	NA
QAX83706.1\|1651716_1652835_-	TIGR00730 family Rossman fold protein	NA	NA	NA	NA
QAX83707.1\|1653187_1653382_+	hypothetical protein	NA	NA	NA	NA
QAX83708.1\|1653382_1653808_-	hypothetical protein	NA	NA	NA	NA
QAX83709.1\|1653997_1654744_+	DTW domain-containing protein	NA	NA	NA	NA
QAX83710.1\|1654967_1655618_+	DNA-binding response regulator	NA	NA	NA	NA
QAX83711.1\|1655692_1656055_+	diacylglycerol kinase	NA	NA	NA	NA
QAX83712.1\|1656051_1656978_-	LysR family transcriptional regulator	NA	NA	NA	NA
QAX83713.1\|1657111_1657891_+	ferredoxin--NADP reductase	NA	NA	NA	NA
QAX87674.1\|1658065_1658764_-\|tRNA	tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO	NA	NA	NA	NA
QAX83714.1\|1658885_1659656_-	3-oxoacyl-ACP reductase	NA	NA	NA	NA
QAX83715.1\|1659784_1660255_-	DUF1456 domain-containing protein	Q9EYF4	Enterobacteria_phage	1.0e-37	51.3
QAX83716.1\|1660327_1661038_-	RNA-binding protein	NA	NA	NA	NA
QAX83717.1\|1661229_1661703_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
QAX83718.1\|1661912_1663250_-	30S ribosomal protein S12 methylthiotransferase RimO	NA	NA	NA	NA
QAX83719.1\|1663539_1665441_+	potassium transporter Kup	M1HZV6	Acanthocystis_turfacea_Chlorella_virus	9.7e-79	34.6
QAX83720.1\|1665885_1667181_-	virulence factor family protein	NA	NA	NA	NA
QAX83721.1\|1667180_1669820_-	hypothetical protein	NA	NA	NA	NA
QAX83722.1\|1670755_1671817_+	DNA polymerase IV	NA	NA	NA	NA
QAX83723.1\|1671905_1672859_-	hypothetical protein	NA	NA	NA	NA
QAX83724.1\|1672876_1674592_-\|tRNA	proline--tRNA ligase	A0A2K9L0T2	Tupanvirus	1.5e-06	25.4

DBSCAN-SWA_2

4056276 : 4062507

uncultured_Caudovirales_phage(83.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAX87746.1\|4056276_4056669_+	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	7.9e-52	76.7
QAX85699.1\|4056670_4057027_+	sulfurtransferase complex subunit TusC	A0A2H4J8C0	uncultured_Caudovirales_phage	5.0e-37	65.0
QAX85700.1\|4057026_4057320_+	sulfurtransferase complex subunit TusB	A0A2H4JG28	uncultured_Caudovirales_phage	7.5e-31	63.6
QAX85701.1\|4057316_4057652_+	sulfurtransferase TusE	A0A2H4J8B6	uncultured_Caudovirales_phage	8.0e-45	77.5
QAX85702.1\|4057648_4058650_+	glycosyl transferase family protein	A0A2H4JBY5	uncultured_Caudovirales_phage	1.8e-161	84.5
QAX85703.1\|4058741_4059743_+	glutathione-dependent reductase	NA	NA	NA	NA
QAX85704.1\|4059831_4061226_-	uroporphyrinogen-III C-methyltransferase	NA	NA	NA	NA
QAX85705.1\|4061226_4062507_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.4e-97	53.6

DBSCAN-SWA_3

5906943 : 5967980

Burkholderia_phage(28.57%)

protease,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAX87311.1\|5906943_5907447_-\|protease	ATP-dependent zinc protease	NA	NA	NA	NA
QAX87312.1\|5907728_5908616_+	acyltransferase	NA	NA	NA	NA
QAX87313.1\|5908617_5909175_-	hypothetical protein	NA	NA	NA	NA
QAX87314.1\|5909323_5909959_+	RNA polymerase subunit sigma-70	NA	NA	NA	NA
QAX87315.1\|5909955_5910630_+	anti-sigma factor	NA	NA	NA	NA
QAX87316.1\|5910838_5911153_+	hypothetical protein	NA	NA	NA	NA
QAX87317.1\|5911210_5912410_-	formaldehyde dehydrogenase, glutathione-independent	A0A2K9L7I1	Tupanvirus	1.9e-11	29.3
QAX87318.1\|5912563_5913421_-	formyltetrahydrofolate deformylase	NA	NA	NA	NA
QAX87319.1\|5913635_5914268_-	sarcosine oxidase subunit gamma	NA	NA	NA	NA
QAX87320.1\|5914411_5917429_-	sarcosine oxidase subunit alpha	NA	NA	NA	NA
QAX87321.1\|5917425_5917755_-	sarcosine oxidase subunit delta family protein	NA	NA	NA	NA
QAX87322.1\|5917769_5919020_-	sarcosine oxidase subunit beta	NA	NA	NA	NA
QAX87323.1\|5919040_5920294_-	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	1.4e-102	53.6
QAX87324.1\|5920556_5921267_-	conjugal transfer protein TraX	NA	NA	NA	NA
QAX87325.1\|5921393_5922434_+	threonine aldolase	NA	NA	NA	NA
QAX87326.1\|5922611_5923436_+	short chain dehydrogenase	NA	NA	NA	NA
QAX87327.1\|5923774_5924875_-	hybrid-cluster NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
QAX87328.1\|5924904_5925102_+	protein GbcA	NA	NA	NA	NA
QAX87329.1\|5925171_5926467_+	aromatic ring-hydroxylating dioxygenase subunit alpha	NA	NA	NA	NA
QAX87330.1\|5926564_5927809_-	metallophosphoesterase	NA	NA	NA	NA
QAX87331.1\|5927834_5929703_-	hypothetical protein	NA	NA	NA	NA
QAX87332.1\|5929827_5933280_-\|holin	choline dehydrogenase	NA	NA	NA	NA
QAX87333.1\|5934229_5934796_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
QAX87334.1\|5934950_5935721_-	electron transfer flavoprotein subunit beta	NA	NA	NA	NA
QAX87335.1\|5935730_5936951_-	electron transfer flavoprotein subunit alpha	NA	NA	NA	NA
QAX87336.1\|5936950_5938900_-	(Fe-S)-binding protein	NA	NA	NA	NA
QAX87337.1\|5939054_5941115_-	N-methylproline demethylase	NA	NA	NA	NA
QAX87338.1\|5941130_5941661_-	hydrocarbon binding protein	NA	NA	NA	NA
QAX87339.1\|5941767_5942745_-	peptidase M19	NA	NA	NA	NA
QAX87793.1\|5942979_5943381_+	hypothetical protein	NA	NA	NA	NA
QAX87340.1\|5943593_5943848_+	cytotoxic translational repressor of toxin-antitoxin stability system	A0A1S5NR91	Burkholderia_phage	1.3e-23	64.3
QAX87341.1\|5943831_5944155_+	transcriptional regulator	A0A1S5NNJ5	Burkholderia_phage	3.7e-31	66.7
QAX87342.1\|5944184_5944601_+	DUF3010 domain-containing protein	NA	NA	NA	NA
QAX87343.1\|5944738_5945683_-	AraC family transcriptional regulator	NA	NA	NA	NA
QAX87344.1\|5945890_5946835_+	glycine/betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
QAX87345.1\|5946956_5947844_+	NADPH:quinone reductase	NA	NA	NA	NA
QAX87346.1\|5948000_5948966_+	carnitine 3-dehydrogenase	NA	NA	NA	NA
QAX87347.1\|5949420_5949897_+	4-hydroxybenzoyl-CoA thioesterase	NA	NA	NA	NA
QAX87348.1\|5949921_5951085_+	gamma-butyrobetaine dioxygenase	NA	NA	NA	NA
QAX87349.1\|5951431_5951695_+	hypothetical protein	NA	NA	NA	NA
QAX87350.1\|5951801_5952905_-	GlxA family transcriptional regulator	NA	NA	NA	NA
QAX87351.1\|5953454_5954831_-	L-serine ammonia-lyase	NA	NA	NA	NA
QAX87352.1\|5955268_5956216_+	glycine/betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
QAX87794.1\|5956282_5957128_+\|holin	choline ABC transporter permease subunit	NA	NA	NA	NA
QAX87353.1\|5957124_5958303_+\|holin	choline ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.2e-25	37.1
QAX87354.1\|5958552_5960550_-	beta-aspartyl-peptidase	A0A2I7QNT1	Vibrio_phage	1.8e-19	26.5
QAX87355.1\|5960977_5961571_+	transcriptional regulator BetI	NA	NA	NA	NA
QAX87356.1\|5961659_5963132_+	betaine-aldehyde dehydrogenase	NA	NA	NA	NA
QAX87357.1\|5963216_5964920_+\|holin	choline dehydrogenase	A0A1V0SI18	Klosneuvirus	3.8e-50	30.1
QAX87358.1\|5965200_5966643_+	peptidase C69	NA	NA	NA	NA
QAX87359.1\|5966642_5967980_+\|protease	Zn-dependent protease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP027218

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection