CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP016379	Anoxybacter fermentans strain DY22613 chromosome, complete genome	24 crisprs	cmr6gr7,cas10,cmr4gr7,cmr5gr11,cmr3gr5,cmr1gr7,cas3,DEDDh,DinG,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1,cas6,c2c10_CAS-V-U3,csa3,cas5	4	1	2	0

1. CP016379

CRISPR-Cas detection and classification

Crispr_ID: CP016379_1

• CRISPR_ID: CP016379_1
• CRISPR_location: 636712-636896
• CRISPR_type: TypeIII
• Repeat_type: ?
• Spacer_info: 2 spacers
• Cas_protein_info: cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1,cas6

Consensus repeat of CP016379_1

Consensus_repeat	Method
GTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACT	PILER-CR

spacers of CP016379_1

>1.1|636750|36|CP016379|PILER-CR
TTGTGACGGTTTGAATTATGATCCAAGTTTCATATA
>1.2|636824|35|CP016379|PILER-CR
CTTTGAGAATTACACGGACCCGACCTGTATCATAA

CRISPR arrays and Neighbor proteins around CP016379_1

CRISPR arrays

The CRISPR arrays of CP016379_1

>merge|CP016379|1|636712-636896|PILER-CR
GTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACTTTGTGACGGTTTGAATTATGATCCAAGTTTCATATAGTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACTCTTTGAGAATTACACGGACCCGACCTGTATCATAAGTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACT

>CP016379|1|1|636712-636896|PILER-CR
GTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACT	TTGTGACGGTTTGAATTATGATCCAAGTTTCATATA
GTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACT	CTTTGAGAATTACACGGACCCGACCTGTATCATAA
GTTAGAATCTAAGTTCCACTAAAACAAGGATTGAAACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72413.1|626326_626611_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72416.1|630523_631117_+|dipicolinate-synthase-subunit-B	unknown	unknown	gnl|CDD|181370
CP016379.1|AZR72426.1|643102_644608_+|hypothetical-protein	csx1	mkCas0109_csx1_CAS-III	unknown
CP016379.1|AZR72417.1|631106_632156_+|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|237845
CP016379.1|AZR72428.1|646684_646990_+|hypothetical-protein	unknown	unknown	gnl|CDD|376658
CP016379.1|AZR72411.1|625143_625413_+|YlmC/YmxH-family-sporulation-protein	unknown	unknown	gnl|CDD|274339
CP016379.1|AZR72429.1|647966_648194_+|hypothetical-protein	unknown	unknown	gnl|CDD|379433
CP016379.1|AZR72424.1|640920_642000_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	COG1567_csm4gr5_CAS-III-A	gnl|CDD|224483
CP016379.1|AZR72423.1|640040_640934_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl|CDD|187815
CP016379.1|AZR72414.1|626675_628817_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72419.1|633433_634312_+|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl|CDD|235107
CP016379.1|AZR72425.1|641999_643100_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl|CDD|187793
CP016379.1|AZR72418.1|632177_633401_+|aspartate-kinase	unknown	unknown	gnl|CDD|236188
CP016379.1|AZR72427.1|645422_646097_+|hypothetical-protein	cas6	cls000004_cas6_CAS-I:CAS-III	gnl|CDD|379957
CP016379.1|AZR72420.1|634494_636168_+|ribonuclease-J	unknown	unknown	gnl|CDD|223668
CP016379.1|AZR72421.1|637228_639577_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl|CDD|187811
CP016379.1|AZR72415.1|629620_630505_+|hypothetical-protein	unknown	unknown	gnl|CDD|181371
CP016379.1|AZR74801.1|647194_647950_+|hypothetical-protein	unknown	unknown	gnl|CDD|223811
CP016379.1|AZR72412.1|625481_626027_+|hypothetical-protein	unknown	unknown	gnl|CDD|378584
CP016379.1|AZR72422.1|639580_640015_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl|CDD|367635

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72422.1|639580_640015_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	8.5e-17	56.4	2.8
CP016379.1|AZR72427.1|645422_646097_+|hypothetical-protein	cas6	cls000004_cas6_CAS-I:CAS-III	2.5e-72	237.7	4.9
CP016379.1|AZR72423.1|640040_640934_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	4.6e-67	220.6	2.5
CP016379.1|AZR72424.1|640920_642000_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	COG1567_csm4gr5_CAS-III-A	2.1e-44	146.7	9.7
CP016379.1|AZR72426.1|643102_644608_+|hypothetical-protein	csx1	mkCas0109_csx1_CAS-III	9.8e-35	115.0	10.1
CP016379.1|AZR72421.1|637228_639577_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	3.8e-159	525.9	14.4
CP016379.1|AZR72425.1|641999_643100_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	1.6e-31	104.6	20.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72416.1|630523_631117_+|dipicolinate-synthase-subunit-B	gnl|CDD|181370	PRK08305, spoVFB, dipicolinate synthase subunit B; Reviewed.	1.68355e-110
CP016379.1|AZR72417.1|631106_632156_+|aspartate-semialdehyde-dehydrogenase	gnl|CDD|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
CP016379.1|AZR72428.1|646684_646990_+|hypothetical-protein	gnl|CDD|376658	pfam01910, Thiamine_BP, Thiamine-binding protein. The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structure suggests a role in protein-protein interactions possibly regulated by the binding of small-molecule ligands. Solution of the structure of the hyperthermophilic anaerobic Thermotoga maritima sequence, UniProtKB:Q9WYV6, shows that this has a beta-alpha-beta-beta-alpha-beta ferredoxin-like fold and assembles as a homotetramer. It was possible to identify a pocket in each monmer that bound an unidentified ligand. It was also found that it bound charged thiamine though not hydroxymethyl pyrimidine. It is proposed that it is transporting charged thiamine around the cytoplasm. Under oxidative conditions this bacterium is under stress, and the transcriiptional unit within which this protein is expressed is up-regulated in these conditions, suggesting that the chelation of cytoplasmic thaimine is part of the response mechanism to such oxidatvie stress, which is mediated by this family.	1.95175e-43
CP016379.1|AZR72411.1|625143_625413_+|YlmC/YmxH-family-sporulation-protein	gnl|CDD|274339	TIGR02888, conserved_hypothetical_protein, sporulation protein, YlmC/YmxH family. Members of this family belong to the broader family of PRC-barrel domain proteins (see pfam05239), but are found only in endospore-forming bacteria of the Firmicutes lineage. Most such species have exactly two members of this family and all have at least one; the function is unknown. One of two members from Bacillus subtilis, YmxH, is strongly induced by the mother cell-specific sigma-E factor. [Cellular processes, Sporulation and germination].	1.97501e-26
CP016379.1|AZR72429.1|647966_648194_+|hypothetical-protein	gnl|CDD|379433	pfam14035, YlzJ, YlzJ-like protein. The YlzJ-like protein family includes the B. subtilis YlzJ protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 72 amino acids in length. There are two completely conserved residues (L and G) that may be functionally important.	1.10578e-21
CP016379.1|AZR72424.1|640920_642000_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl|CDD|224483	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	6.45426e-27
CP016379.1|AZR72422.1|639580_640015_+|type-III-A-CRISPR-associated-protein-Csm2	gnl|CDD|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	2.06717e-11
CP016379.1|AZR72419.1|633433_634312_+|4-hydroxy-tetrahydrodipicolinate-synthase	gnl|CDD|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	1.99925e-163
CP016379.1|AZR72425.1|641999_643100_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl|CDD|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	9.29153e-22
CP016379.1|AZR72418.1|632177_633401_+|aspartate-kinase	gnl|CDD|236188	PRK08210, PRK08210, aspartate kinase I; Reviewed.	0
CP016379.1|AZR72427.1|645422_646097_+|hypothetical-protein	gnl|CDD|379957	pfam17262, DUF5328, Family of unknown function (DUF5328). This family of unknown function can be found in Bacteria and Archaea. Some of the proteins in this family are annotated in UniProt as putative DNA repair proteins.	8.56447e-39
CP016379.1|AZR72420.1|634494_636168_+|ribonuclease-J	gnl|CDD|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
CP016379.1|AZR72421.1|637228_639577_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl|CDD|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	2.29175e-155
CP016379.1|AZR72415.1|629620_630505_+|hypothetical-protein	gnl|CDD|181371	PRK08306, PRK08306, dipicolinate synthase subunit DpsA.	3.89324e-119
CP016379.1|AZR74801.1|647194_647950_+|hypothetical-protein	gnl|CDD|223811	COG0740, ClpP, Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	4.00194e-34
CP016379.1|AZR72412.1|625481_626027_+|hypothetical-protein	gnl|CDD|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	0.00446039
CP016379.1|AZR72423.1|640040_640934_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl|CDD|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.19481e-71

Protein sequences

>CP016379.1|AZR72420.1|634494_636168_+|ribonuclease-J
MSKKLKNETVSIIPLGGVGEIGKNMMVVEVGDEILVIDAGIMFPEDDLLGIDYVIPDITYLIENKERIQGIALTHGHEDHIGALPYVLREINVPVYGTRLTMGLVEGKLKEHNMLSGVKLRVVNPGSSVMIGSFRVDFIRVNHSIADACALAIHTPIGPLVYASDFKFDQTPVDGHVADFHKLADLGTQGVLALFSDSTNAEHEGVTLSEKVVGESIEEAVRMAKGRIIVATFASNIHRIQQVVDAAFKYNRKIAITGRSMVNYVNIARDLGYLHIPEGMMIDLKDANRYRDHQLCFLTTGSQGEPMAALTRMARGDHRQINIKPGDTVIVSASAIPGNEKFLAQTINQLFKRGANVVYDAVSGVHVSGHASQEELKLMLNLVKPRFFIPVHGEYRHLYHHAELAKEVGIPEENIFITEPGSVLQFTNDNGKIAGTVTAGQVLVDGLGVGDVGNIVLRDRRLLSQDGILIVVLTIDKDSGKIVSGPDIITRGFVYIRESEELILAATERVEKALAKCEDKGITDWGILKSTIRDALGAFIYQKIKRKPMILPIIMEV
>CP016379.1|AZR72419.1|633433_634312_+|4-hydroxy-tetrahydrodipicolinate-synthase
MTIFGEVLTAMVTPFYEDFTVNYEGVRKLARYLVENGSDGLVVLGTTGESPTLTKEEKLEILRVVKDEVGEKARIIAGTGTNATKAAIEMTIEAEKVGVDGVMLVCPYYNKPPQEGLYQHFKSIAESTGLPIMIYNVPGRTGKNIEAETIARLAEIDNIVAVKEASGNLNQVSKIRSLTSPDFAIYSGDDSLTLPILAVGGTGVVSVASHVVGNQIKEMIKLFKAGKVREASLLHCHLLPIFQGIFITTNPIPIKFLLNKLGHQVGPVRPPLVNPTEEESKYLLKLLQSIKK
>CP016379.1|AZR72418.1|632177_633401_+|aspartate-kinase
MKIIVQKFGGSSLANTTGREQAVKKIKEAIEKGYRPVVVVSAMGRKGSPYATDTLIAFAKKVHFEIEPRELDLLLSCGEVISAVIFGQTLNKHGFKPIALTGAQAGIITDENFGETRIIEVNPSRILKELKNGKIPVVAGFQGISKSGEITTLGRGGSDTTATALGAALKAEYIEIFTDVDGVMTADPRIVPTAKTIKKASYEDVCEMAHGGAKVIHPRAAEIARRERIPVRVRSTFTDNDGTLIKEMGFEDGVVEIKGDRPVTGIATRNNIIFFKIIPRLQLENATGLGAFKVIADQGISVDFINVKPDSISFIVDAPCADKVRQVLDAWDYKYEISNEYCKITLIGGGMTGRPGVMAKIVEALASEAIPIFQSTDSRSTISVLIKERDQVRAMRALHRAFQLDQE
>CP016379.1|AZR72417.1|631106_632156_+|aspartate-semialdehyde-dehydrogenase
MLFENGRKRGDTVSGYKVAILGASGAVGRMMVKVLEERNFPVRDLKLLATERSAGKKIDFHGEKLTIEVAHPDQFKGYDLALFSAGSSVSRSIALEAVKRGCVVIDNSNAWRMEPDVPLVVPEVNPEELENHRGIIANPNCSTIQMVVALKPIKDRFGLSRIIVSTYQAVSGTGLRAIEELKSQSLHMLNGETKEPEVYPYPIAFNLLPHIDTFSENGYSREEMKMINETRKILKDPKIKIAATAVRVPVFYGHSESIYIKTIEPAEVIEIRQVLSKAPGVVVYDNLEKLQYPMPNLVEDNDQVWVGRIRRDLDEDCGYHLWVVANNLRKGAATNAVQIGEELMKRGLL
>CP016379.1|AZR72416.1|630523_631117_+|dipicolinate-synthase-subunit-B
MDLKGKKIGFCLTGSFCTFDKVIPQIERLVEMGADIVPIMSHNAYSWDTKFGPAEKWRKMIEEITGKKILHTIVEVEPIGPGKIPLDVVVVAPATGNTLAALANGLTNGPVPMACKAHWRNGKPVVIAISTNDGLGASAKNIGILHDKALTFMVPYGQDNPHKKEKSLVAHFEYIPDTIKAALEGKQFQPVLIPHAF
>CP016379.1|AZR72415.1|629620_630505_+|hypothetical-protein
MKKLTGYRIGILGGDERERVMMNCLIEKGAKLKVLGDPGGELSEKIQVVSTVEELVKDVHVLIAPMSGTDAEGMIKARFIDEPIYMDEDFFALVGSEIPVLIGMTNEKVKSLAKAANVNLQLIATREDVGILNAIPTAEGAIQIAMEELPITIHGSKSLVMGLGKCGLTLAWRLRALGSEVYGVTRSPEGIAKARDLGIHIISYDELAKYLPEFDLIYNTAPAMVLPEERIRLIRKDALIIDLASAPGGTDFEAAKKYGIKALLALGLPGKVAPKTAGLILCRVVTEMILDVLK
>CP016379.1|AZR72414.1|626675_628817_+|hypothetical-protein
MKRGFLIFLILEICIQIAQITFAYGTPVGFPENIDQITYFASDPIQPGLWSFNLITGEKKLIIKGISDNYKFSPDGRYLAFLVNNCDWGIGQSNTISLWVRDLAEGIEYVIQSIFDTENNLDTTFEWFANDKLAVIQRTDLKNSRIQIYKPNGKLIWISPENYQFLSFANQKVLLKDNLNENLVIYCLLTNTYKILPVKELLVNASLSIKTNYLCYQTFRKIILLNLNTLEKVYIDVGKQSEVQFDWSPDENYLIYQTLPGSGELYQLKVFNVQTGIKEFEVNSEKQIYYSWSSDEKQVVISLYQNGWNLLVWFPDQYNLMVIQSGLVTQPIPVYRQGTHQFYYLTHVDYYPVVYSYDVDYNRLDVTLSGPEDAVWSRLNLIPVTFFKENEAYDLMYWAGWSEVAEIQYLRSLEIFSNEDYYTVLKWAPFHPTLVYKENDRNLIIIDETGKMKRIYTGTKISEPFWNDDGSYICFTDQEERKRLILYNIFKNQIDIYPLESDNLELIQWMNGQIWFYDGRIRGYYPLGDDWDNLQRWKDYWWPLPKIKKAHYLAKTLWQIGANLWFRTEDGEFKVITRLTEGPPQNWQVQWNGFAQWSPDDEKILYNRLLTRTTFYGQEKKREIWVMDKNGTNHRYLCEGAYSQWLDNYRFLFLKEGNLYLANLVTGQINGLDTPELEEIAFVPSCNGASLVVVIARDEEGKLGLYLYKIKYR
>CP016379.1|AZR72413.1|626326_626611_+|hypothetical-protein
MIVDTGIKVFKQQIVKIEKIINQHGILLIDRTPMSVTIDNNISMILDEFIFREILNGSQNFLDIHVRVFRKFLTPSYGVFFIPTFIIIKEEIFL
>CP016379.1|AZR72412.1|625481_626027_+|hypothetical-protein
MPTVIGVFTNRSQAERAIAEIRSEGVSEDRVSIVARQGYIHGDENDTNDSFVQMVKSQTEKDQETNSTVEANERQNLSTGVTTGGALGGIGGLLAGAGLFTIPGLGPILAIGPIVSGLAGAAVGGIAGSLIDMGIAPERSEHYQAQVEQGGILGAVECDQSKINDVAAIFRRNGARDVETY
>CP016379.1|AZR72411.1|625143_625413_+|YlmC/YmxH-family-sporulation-protein
MRLSKLAGKEIINMHDGGRLGVVAETDLVVHPETGELESIIIPNHGNFFSIFKDEKYLVIPWQAIKKIGSEVIIVDLNSPRNNRDRLTS
>CP016379.1|AZR72421.1|637228_639577_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MDKDRIYLAALLHDVGKFLERAKYYGDKNLARLLLNKLEFSNKSYFFSSCLEEVIQSVLYHYEPRDDFERIIQLADWLSSSEGRDEKENTDNVDVYYKMPLQSIFGRLFKEEKKYGYKLKKMSLETIFPEDGLKEISYRDYVDDFLDELVKVNNESQLYYLLEKYLWSVPEQASGCYTDISLFDHSKTTAAIAVCLYHQYQAGELDKKELNLMTDSTKNQFLLINADISGIQDFIFNISSKGASKSLKGRSVYITLISEIVARYIIDELELKEANLLYNGGGNFYILAPACKEEKLKEVRKNILETLLNAHNGELYFAIAGLPFSPADFSNFAELWTRASRKVAELKQKKWSEIDLKSNFKKIFGPLNDGESQNNTCDVCGVSRKNRELISNEDDLKICSMCNSFIELTKEKLKEANYYIIKRGNYGENKSINNYNDVFKSFGYQIDFLKSFDNKKSSNELVYKINDTNFLEEGCDGFIFGAYNLPINEKGNLMTFEELAVRAVREGRGDKKLGVLKLDVDNLGWIFIKGFEKNKTISRITSLSRMLGLYFKGYINCLIKQKGWQNKIYVVFSGGDDTFIVGSWNTIIEFGKEFYERFRDYTCHHSKITFSAGISIFRYNFPVVKFAEITEGALERAKNFIEENEKIPGKNKISLFGEVFNWEEFKRIIEIKDVLIDIVKRNGNKRAILNKVMRSTKGFKKILEQSNKNLFDNLRFWRLVYYLRELNKNNKNDENDAEKIINIYQKIVINNLLHKKEVKKIMIIPVAVKMAEMETKKYSKGD
>CP016379.1|AZR72422.1|639580_640015_+|type-III-A-CRISPR-associated-protein-Csm2
MKKERGKTKYKNDRFSNRNELINYFKNVVLDLDNADYDEFCEKVKKYAEQLRPQKYDKTNKVTTSMIRKVYNKIMNAKSIIDLKMLRPQFAYLAGRNEKNVVLKEFIEMLDSIVKSLRDQKQLVYFQRFMEAIVAYRKYVGDDE
>CP016379.1|AZR72423.1|640040_640934_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MQLKGKIFIEGKIIVKTGLMIGGSDTDVMIGGIENNVIKNSEGIPYIPGSSLKGKIRCLLELAEGRYQGLIIVSEKDDSGKFKKHYNEFNNAEEYEKIKNKYKDNSQYKISIKANHCNCGECDICAIFGVSASVNSKVGRTRLYVRDAELDLIHFEENRDTLFKNLELNYTESKWENTIDRLTSAASNPRLTERVPAGARFNFNLVYNIFEDEDIDRFNFVLKGLRLLEDDYLGGSGSRGYGKIKFDDLEFTIKTLEEYEGKNVAVPIYNGEKKDLSISFEELDFSKVKRRIISESS
>CP016379.1|AZR72424.1|640920_642000_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MKVVKLLIGDRAKFHFGNYKRELTSVFSSDSLFSAIINNYALLYPEKTEQIIDKFRKREYLISSCYLGIDFWNGEKKKKTIYFLIKPFWRIGRDRNEENDDDLRKRKMIKKLKYLSLNVYNDLLNAWNEEKGFFEYDLSAQFIIGNKFCISNQEVDDLNLTFEEKRKLADLNFIKEYSTPKVAVNRITNKSEAFYYENNIELSYKKIGDYTLKPFFYFLANQAFVENKEIRASLNLLCDEGLGGRRSMGIGQFQNCVYEDITGVLSHEGNKYISLSIVFPKKEEVDNVLSYNLVKRNGYIFSNGGRAFRKKDVRVMQEGSIFNCKVEGQFLDLKPEGFKLPHKVYLNGNSFLIGFGGGK
>CP016379.1|AZR72425.1|641999_643100_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MNLVLEILTPMHIGNGDVLSPYSDYIYKDGQIYYINHQKLEDFIFKLDNASSLIDKFVDIIKKQASGNQSSKYKLENFFEANNLDIKEFTDKIVDCNTDIKNKQILKCIYTGSRPYIPGSTLKGAIRTSLIYGYLKRNSYNLNEIISIWKQNKYSYIGQDIFGKFSRDIMKFLQVSDTEPFSDTDIEIIETYRVDIESGKTKNPVVFECLKRNLSTKFSMTSKGKKNYHHLEDDFDYLYEQNEAVIFDYINDFFEDAIKREISELKSKYKGKGENPFLNIISFYEQLLNEIMEFKQNKNGAVLRIGAGKTFFENTINNIFSKNEFEEIKKIKKIKNNNPFPKTRTVVVDCEIIKNSLGWIKIYKEE
>CP016379.1|AZR72426.1|643102_644608_+|hypothetical-protein
MATCAYYILGNSDLKVIDMDGNEISKVDNFREYTRELADILKNTNSTAKKDFLKFDKEVEIKFQNKGEKNILKISKIRMPIFTAYIDKINQTQHKKPDKIIFFYTNQENPDKGDTIYLYQIIRLFAQKRYRYNESDICGIEVSCNPSNYEEVGRFYDEYFEKNEEQIKYNSMNYILSTTGTPAMTNILSVKMLDYPHQYYYGERADNGGTRIIELNYFTKLNCDRYRRLIDRTIKDLCYNNASEIFKESPFRKKFEVRQLLKVAYHLRNFNFENAYEEAEILEQNKWLLDRVSDLQLKTEERLSLIYDFMEISLENHKYLETVALLFGLLDNLRQYLFEKTFRIKIKDEKTNSFSEFNNFIESKPDLKSYFDKKGIKYKNAPTKVVLNKILSDFLKYGDKKTPEDRRNSNYIERFFQLNEKVEHLQDLRNMTPFAHGVKGIILEDICNLKNTISDILEFLKLIDIKKENDDKKNNKKDDKKDEDNIFKKINNAIIELLEKY
>CP016379.1|AZR72427.1|645422_646097_+|hypothetical-protein
MIIKQSILQFEIGENLSLNYGHYLRGYFANRFSEVLFHNHLQDGKLRYGYPLIQYKIVEGKPIVIGLNEGADLLGKYFLDLTELVLRNKVYKGFEKKLEVKNIKIKTTSTMKYCYQFLSPWVALNQKNYHIYLQNKNSMHFNEKEFLQRLLVGNILSFAKSIGWWVESQIFILPEVRQVMVNFKGQKLIGFVGHFYSNVALPDLIGLGNSSARGFGTIKRKVRI
>CP016379.1|AZR72428.1|646684_646990_+|hypothetical-protein
MPIAEVTVVPLGTGDTSLSRYVADCHRILKKEKIKFQLTPMGTILEGDLDKIFEVVKKLHEVPFDAGALRVSTTLKIDDRRDRKASMEQKIRSVEEKLQES
>CP016379.1|AZR74801.1|647194_647950_+|hypothetical-protein
MTPEQPQRHEPAGNGAPESVPKRKRPIRLRNASMTALRQFGQNNIPTDVQSDIHMLSIIGQIEGHMVLPPKNKSTKYEHILPQLMAIEENPKIKGLLVVLNTVGGDIEAGLAIAEMLASMTKPTVSLILGGGHSIGVPIAVAADYSFIARTASMTIHPIRLTGLVISVPQTYEYLEKMQDRVVKFVTSHSNISEDRFRQLMFQTGELVRDVGTVLVGEAAVKEGLIDEVGGLAQAIQKLHAYINENQKNLH
>CP016379.1|AZR72429.1|647966_648194_+|hypothetical-protein
MHYSIIPSEIIFDEWDGEELNNYQEITFENRRFIVEPLEKNQAKIVQLLSSNPYDFLNRRYQPGSIIKFSPQMEN

Crispr_ID: CP016379_2

• CRISPR_ID: CP016379_2
• CRISPR_location: 715751-715852
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_2

Consensus_repeat	Method
TTTCAGTCTCCTACTTAGTGGAGT	CRISPRCasFinder

spacers of CP016379_2

>2.1|715775|54|CP016379|CRISPRCasFinder
GTAGGTTGTAACAAAGAGATAGGTGCAGAAATGGGGTTAAGTATCGAACTGAAG

CRISPR arrays and Neighbor proteins around CP016379_2

CRISPR arrays

The CRISPR arrays of CP016379_2

>merge|CP016379|2|715751-715852|CRISPRCasFinder
TTTCAGTCTCCTACTTAGTGGAGTGTAGGTTGTAACAAAGAGATAGGTGCAGAAATGGGGTTAAGTATCGAACTGAAGTTTCAGTCTCCTACTTAGCGGAGT

>CP016379|2|1|715751-715852|CRISPRCasFinder
TTTCAGTCTCCTACTTAGTGGAGT	GTAGGTTGTAACAAAGAGATAGGTGCAGAAATGGGGTTAAGTATCGAACTGAAG
TTTCAGTCTCCTACTTAGCGGAGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223737
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein	unknown	unknown	gnl|CDD|375343
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72471.1|704194_704689_+|4Fe-4S-ferredoxin	unknown	unknown	gnl|CDD|224065
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	5.05288e-87
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein	gnl|CDD|375343	pfam17806, SO_alpha_A3, Sarcosine oxidase A3 domain. This short domain is found in Heterotetrameric Sarcosine Oxidase's alpha A3 domain. This domain binds to FMN in sarcosine oxidase. This domain is related to pfam04324 but lacks its iron binding cysteine residues.	2.48632e-17
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72471.1|704194_704689_+|4Fe-4S-ferredoxin	gnl|CDD|224065	COG1142, HycB, Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion].	8.30709e-10
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23

Protein sequences

>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase
MKNKASVVVIGGGVVGCSIAYNLARLGVKDVVVVEKNFLASGSTGRCGAGVRQQWGTEMNCRLAKESMKIFENMNEILKTKRDIELKQEGYLLLAYSEREMDQFKKNIELQNSLGIPSHLVTPEEAKEIVPYLNTENLIGGAFCPTDGHANPFLVTQAYADAARYLGVEFYLRTEVTGIRQEKGRIVGVETNRGFIATEKVVNTAGGYSQVIGKMVGLDLPVYSERHQILVTEPVEKMQGPMVMSFSYNIYCQQNPHGSFIMGFGDPNEPRDFNIRSSWQFLEEMARKVTWLLPPLKHLRVVRQWAGLYNVTPDRQPILCETPQVPGFYLAIGFSGHGFMIAPMVGILMAEMITGQKLSMDLELDLGRFERGELILEPSVV
>CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein
MENGKIIVCRCEDVTLAEIRQLIEEGFTSLDEIKRIARCGMGPCQGKTCSQIIAREIAAATGKSLEEIQIPTNRPPIGGIKLGELVGEENEE
>CP016379.1|AZR72471.1|704194_704689_+|4Fe-4S-ferredoxin
MLESTGVPTVEDLKARMPSKERLARGPVAMIECFQRIPCDPCYHSCKRGAISKLIDINDIPQVDYEKCNGCGLCISNCPGLAIFVLDQNYDEKYGLIKMPYELLPRPEIGEEVVALNREGQEVCKGKVVEVRDGKIQDKTAIIGVAVPKKFLMEVRNIKVGRSK
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS

Crispr_ID: CP016379_3

• CRISPR_ID: CP016379_3
• CRISPR_location: 717394-717562
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_3

Consensus_repeat	Method
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	CRISPRCasFinder

spacers of CP016379_3

>3.1|717424|37|CP016379|CRISPRCasFinder
TTCACAGGGGACTGGCGGCAAGCCTGGCAAGGTGTTG
>3.2|717491|41|CP016379|CRISPRCasFinder
TTGGAAAAAGACACGGGATACAAAATCTGGCAGCCCGACGT

CRISPR arrays and Neighbor proteins around CP016379_3

CRISPR arrays

The CRISPR arrays of CP016379_3

>merge|CP016379|3|717394-717562|CRISPRCasFinder
GTTTCAATTCCTTCTAGGTAGGCTACAAACTTCACAGGGGACTGGCGGCAAGCCTGGCAAGGTGTTGGTTTCAATTCCTCATAGGTAGGCTAAAAACTTGGAAAAAGACACGGGATACAAAATCTGGCAGCCCGACGTGTTTCAATTCCTCATAGGTAGGCTAAAAACC

>CP016379|3|2|717394-717562|CRISPRCasFinder
GTTTCAATTCCTTCTAGGTAGGCTACAAAC	TTCACAGGGGACTGGCGGCAAGCCTGGCAAGGTGTTG
GTTTCAATTCCTCATAGGTAGGCTAAAAAC	TTGGAAAAAGACACGGGATACAAAATCTGGCAGCCCGACGT
GTTTCAATTCCTCATAGGTAGGCTAAAAACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223737
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein	unknown	unknown	gnl|CDD|375343
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	5.05288e-87
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein	gnl|CDD|375343	pfam17806, SO_alpha_A3, Sarcosine oxidase A3 domain. This short domain is found in Heterotetrameric Sarcosine Oxidase's alpha A3 domain. This domain binds to FMN in sarcosine oxidase. This domain is related to pfam04324 but lacks its iron binding cysteine residues.	2.48632e-17
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase
MKNKASVVVIGGGVVGCSIAYNLARLGVKDVVVVEKNFLASGSTGRCGAGVRQQWGTEMNCRLAKESMKIFENMNEILKTKRDIELKQEGYLLLAYSEREMDQFKKNIELQNSLGIPSHLVTPEEAKEIVPYLNTENLIGGAFCPTDGHANPFLVTQAYADAARYLGVEFYLRTEVTGIRQEKGRIVGVETNRGFIATEKVVNTAGGYSQVIGKMVGLDLPVYSERHQILVTEPVEKMQGPMVMSFSYNIYCQQNPHGSFIMGFGDPNEPRDFNIRSSWQFLEEMARKVTWLLPPLKHLRVVRQWAGLYNVTPDRQPILCETPQVPGFYLAIGFSGHGFMIAPMVGILMAEMITGQKLSMDLELDLGRFERGELILEPSVV
>CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein
MENGKIIVCRCEDVTLAEIRQLIEEGFTSLDEIKRIARCGMGPCQGKTCSQIIAREIAAATGKSLEEIQIPTNRPPIGGIKLGELVGEENEE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK

Crispr_ID: CP016379_4

• CRISPR_ID: CP016379_4
• CRISPR_location: 718056-718295
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_4

Consensus_repeat	Method
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	CRISPRCasFinder
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	CRT
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	PILER-CR

spacers of CP016379_4

>4.1|718086|39|CP016379|CRISPRCasFinder,CRT
CCACCCTTTGGGTGGATTGTATAGCCATTCCTTTAGTAT
>4.2|718155|41|CP016379|CRISPRCasFinder,CRT,PILER-CR
AAAAATTTTGTAAGGTACTTATACCAATTATCAAAACATGA
>4.3|718226|40|CP016379|CRISPRCasFinder,CRT,PILER-CR
TTAAGAAACTTTATAGAATACACATCTACAACAAACACGT

CRISPR arrays and Neighbor proteins around CP016379_4

CRISPR arrays

The CRISPR arrays of CP016379_4

>merge|CP016379|4|718056-718295|CRISPRCasFinder,CRT,PILER-CR
TTGTCTGGACCTCATAGGTAGGCTACAAACCCACCCTTTGGGTGGATTGTATAGCCATTCCTTTAGTATGTTTCAATTCCTTCTAGGTAGGCTAGAAACAAAAATTTTGTAAGGTACTTATACCAATTATCAAAACATGAGTTTCAATTCCTTCTAGGTAGGCTAGAAACTTAAGAAACTTTATAGAATACACATCTACAACAAACACGTGTTTCAATTCCTTCTAGGTAGGCTAGAAAC

>CP016379|4|3|718056-718295|CRISPRCasFinder
TTGTCTGGACCTCATAGGTAGGCTACAAAC	CCACCCTTTGGGTGGATTGTATAGCCATTCCTTTAGTAT
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	AAAAATTTTGTAAGGTACTTATACCAATTATCAAAACATGA
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	TTAAGAAACTTTATAGAATACACATCTACAACAAACACGT
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC

>CP016379|4|1|718056-718295|CRT
TTGTCTGGACCTCATAGGTAGGCTACAAAC	CCACCCTTTGGGTGGATTGTATAGCCATTCCTTTAGTAT
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	AAAAATTTTGTAAGGTACTTATACCAATTATCAAAACATGA
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	TTAAGAAACTTTATAGAATACACATCTACAACAAACACGT
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC

>CP016379|4|2|718125-718295|PILER-CR
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	AAAAATTTTGTAAGGTACTTATACCAATTATCAAAACATGA
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC	TTAAGAAACTTTATAGAATACACATCTACAACAAACACGT
GTTTCAATTCCTTCTAGGTAGGCTAGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223737
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein	unknown	unknown	gnl|CDD|375343
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	5.05288e-87
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein	gnl|CDD|375343	pfam17806, SO_alpha_A3, Sarcosine oxidase A3 domain. This short domain is found in Heterotetrameric Sarcosine Oxidase's alpha A3 domain. This domain binds to FMN in sarcosine oxidase. This domain is related to pfam04324 but lacks its iron binding cysteine residues.	2.48632e-17
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72473.1|704956_706102_+|FAD-dependent-oxidoreductase
MKNKASVVVIGGGVVGCSIAYNLARLGVKDVVVVEKNFLASGSTGRCGAGVRQQWGTEMNCRLAKESMKIFENMNEILKTKRDIELKQEGYLLLAYSEREMDQFKKNIELQNSLGIPSHLVTPEEAKEIVPYLNTENLIGGAFCPTDGHANPFLVTQAYADAARYLGVEFYLRTEVTGIRQEKGRIVGVETNRGFIATEKVVNTAGGYSQVIGKMVGLDLPVYSERHQILVTEPVEKMQGPMVMSFSYNIYCQQNPHGSFIMGFGDPNEPRDFNIRSSWQFLEEMARKVTWLLPPLKHLRVVRQWAGLYNVTPDRQPILCETPQVPGFYLAIGFSGHGFMIAPMVGILMAEMITGQKLSMDLELDLGRFERGELILEPSVV
>CP016379.1|AZR72472.1|704688_704967_+|(2Fe-2S)-binding-protein
MENGKIIVCRCEDVTLAEIRQLIEEGFTSLDEIKRIARCGMGPCQGKTCSQIIAREIAAATGKSLEEIQIPTNRPPIGGIKLGELVGEENEE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK

Crispr_ID: CP016379_5

• CRISPR_ID: CP016379_5
• CRISPR_location: 720681-720864
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_5

Consensus_repeat	Method
GTTTCAGTCTCCTACTTAGCGGAGTCTAGGTTGCAACCT	PILER-CR

spacers of CP016379_5

>5.1|720720|35|CP016379|PILER-CR
GAAGGGCAATGGGAATTGAAGGTTTCTACCATCTT
>5.2|720794|38|CP016379|PILER-CR
ATGGAAGAGCTGGGTAATTGTTGTGCAGTATGTTACAA

CRISPR arrays and Neighbor proteins around CP016379_5

CRISPR arrays

The CRISPR arrays of CP016379_5

>merge|CP016379|5|720681-720864|PILER-CR
GTCTCCTACTTAGCGGAGTGTAGGTTGCAACCTGAAGGGCAATGGGAATTGAAGGTTTCTACCATCTTGTTTCAGTCTCCTAGTTAACGGAGTCTAGGTTGCAACATATGGAAGAGCTGGGTAATTGTTGTGCAGTATGTTACAAGTTTCAGTCTCCTACTTAGCGGAGTCTAGGTTGCAACCG

>CP016379|5|3|720681-720864|PILER-CR
GTCTCCTACTTAGCGGAGTGTAGGTTGCAACCTGAAGGG	CAATGGGAATTGAAGGTTTCTACCATCTTGTTTCA
GTCTCCTAGTTAACGGAGTCTAGGTTGCAACATATGGAA	GAGCTGGGTAATTGTTGTGCAGTATGTTACAAGTTTCA
GTCTCCTACTTAGCGGAGTCTAGGTTGCAACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_6

• CRISPR_ID: CP016379_6
• CRISPR_location: 720887-720997
• CRISPR_type: TypeV-U3
• Repeat_type: ?
• Spacer_info: 1 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_6

Consensus_repeat	Method
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	CRISPRCasFinder

spacers of CP016379_6

>6.1|720924|36|CP016379|CRISPRCasFinder
TTATATTGATTCTAATGGTAAGATATATTTCTTGGT

CRISPR arrays and Neighbor proteins around CP016379_6

CRISPR arrays

The CRISPR arrays of CP016379_6

>merge|CP016379|6|720887-720997|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGTGAAAATTGCATTCAAACTTATATTGATTCTAATGGTAAGATATATTTCTTGGTGTTTCAATCCTTGTTTTAGTGGAACTTGCGTTGCTTAT

>CP016379|6|4|720887-720997|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGTGAAAATTGCATTCAAAC	TTATATTGATTCTAATGGTAAGATATATTTCTTGGT
GTTTCAATCCTTGTTTTAGTGGAACTTGCGTTGCTTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_7

• CRISPR_ID: CP016379_7
• CRISPR_location: 721533-721716
• CRISPR_type: TypeV-U3
• Repeat_type: ?
• Spacer_info: 2 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_7

Consensus_repeat	Method
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	CRISPRCasFinder

spacers of CP016379_7

>7.1|721570|35|CP016379|CRISPRCasFinder
TTTGTCAACCCGCCTATTAGTATAGGTGGGTTTTT
>7.2|721642|37|CP016379|CRISPRCasFinder
TTGTCCCAGATGTTGACCTCCAAAACAAAATCCTCCC

CRISPR arrays and Neighbor proteins around CP016379_7

CRISPR arrays

The CRISPR arrays of CP016379_7

>merge|CP016379|7|721533-721716|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGTGGAACTATCATTCAAACTTTGTCAACCCGCCTATTAGTATAGGTGGGTTTTTGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACTTGTCCCAGATGTTGACCTCCAAAACAAAATCCTCCCGTTTCAATCCTTGTTATAGTGGAACTTGCGTTGCTTAT

>CP016379|7|5|721533-721716|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGTGGAACTATCATTCAAAC	TTTGTCAACCCGCCTATTAGTATAGGTGGGTTTTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TTGTCCCAGATGTTGACCTCCAAAACAAAATCCTCCC
GTTTCAATCCTTGTTATAGTGGAACTTGCGTTGCTTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_8

• CRISPR_ID: CP016379_8
• CRISPR_location: 721725-721963
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_8

Consensus_repeat	Method
GTTTCAATTCCTTATAGGTAGGCTA	CRT
AGTTTCAATTCCTTATAGGTAGGCTAGAAACC	PILER-CR

spacers of CP016379_8

>8.1|721750|44|CP016379|CRT
CAAACCGTCACGGTTCAGGCACCTACTCAGGTGAGTTATGATAT
>8.2|721819|45|CP016379|CRT
CACACCAAGGAGTACTTCAACTTTTTATGAATACTTCCCGAAAGA
>8.3|721889|44|CP016379|CRT
GAAACATTCGCTATACTGATTAACATAACTTTACCATACACTTA
>8.4|721826|38|CP016379|PILER-CR
AAGGAGTACTTCAACTTTTTATGAATACTTCCCGAAAG
>8.5|721896|37|CP016379|PILER-CR
TTCGCTATACTGATTAACATAACTTTACCATACACTT

CRISPR arrays and Neighbor proteins around CP016379_8

CRISPR arrays

The CRISPR arrays of CP016379_8

>merge|CP016379|8|721725-721963|CRT,PILER-CR
GTTTCAAATCCTGACAGGTAGGCTACAAACCGTCACGGTTCAGGCACCTACTCAGGTGAGTTATGATATGTTTCAATTCCTTATAGGTAGGCTACACACCAAGGAGTACTTCAACTTTTTATGAATACTTCCCGAAAGAGTTTCAATTCCTTATAGGTAGGCTAGAAACATTCGCTATACTGATTAACATAACTTTACCATACACTTAGTTTCAATTCCTTATAGGTAGGCTAGAAACC

>CP016379|8|2|721725-721957|CRT
GTTTCAAATCCTGACAGGTAGGCTA	CAAACCGTCACGGTTCAGGCACCTACTCAGGTGAGTTATGATAT
GTTTCAATTCCTTATAGGTAGGCTA	CACACCAAGGAGTACTTCAACTTTTTATGAATACTTCCCGAAAGA
GTTTCAATTCCTTATAGGTAGGCTA	GAAACATTCGCTATACTGATTAACATAACTTTACCATACACTTA
GTTTCAATTCCTTATAGGTAGGCTA

>CP016379|8|4|721794-721963|PILER-CR
GTTTCAATTCCTTATAGGTAGGCTACACACCA	AGGAGTACTTCAACTTTTTATGAATACTTCCCGAAAGA
GTTTCAATTCCTTATAGGTAGGCTAGAAACAT	TCGCTATACTGATTAACATAACTTTACCATACACTTA
GTTTCAATTCCTTATAGGTAGGCTAGAAACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_9

• CRISPR_ID: CP016379_9
• CRISPR_location: 722276-722753
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 6 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_9

Consensus_repeat	Method
GTTTCAGTCTCCTANNTANCGGAGT	CRT
AAGTTTCAGTCTCCTAGCTAACGGAGTATAGGTTGCAACAAA	PILER-CR

spacers of CP016379_9

>9.1|722301|48|CP016379|CRT
GTAGGTTGCAACGCTCGAATTAAACCAGATTTCCATTACGGACAGCAA
>9.2|722374|50|CP016379|CRT
CTAGATTGCAACGCAAGTGGTTTTAGAGGCATCGAATGGGGTGCTTCGAA
>9.3|722449|52|CP016379|CRT
CTAGGTTGCAACATAGAGTGATCGAAGAGATCGCTCGGAATGATGAAGATGC
>9.4|722526|50|CP016379|CRT
ATAGGTTGCAACACCGGGGATTATTGGACTTTTAAAACTTCACATTATAA
>9.5|722601|53|CP016379|CRT
ATAGGTTGCAACAAATCTGCCAAATTCATCGAAGCCCGGGCTGTCATATATGA
>9.6|722679|50|CP016379|CRT
CTAGATTGCAACGCAATGTATAATTTATATAATAATGATTATTATATCAT
>9.7|722464|35|CP016379|PILER-CR
GAGTGATCGAAGAGATCGCTCGGAATGATGAAGAT
>9.8|722541|33|CP016379|PILER-CR
GGGGATTATTGGACTTTTAAAACTTCACATTAT

CRISPR arrays and Neighbor proteins around CP016379_9

CRISPR arrays

The CRISPR arrays of CP016379_9

>merge|CP016379|9|722276-722753|CRT,PILER-CR
ATTGGGGTCTCCTACTTAGCGGTGTGTAGGTTGCAACGCTCGAATTAAACCAGATTTCCATTACGGACAGCAAGTTTCAGTCTCCTACTTAACGGAGTCTAGATTGCAACGCAAGTGGTTTTAGAGGCATCGAATGGGGTGCTTCGAAGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACATAGAGTGATCGAAGAGATCGCTCGGAATGATGAAGATGCGTTTCAGTCTCCTAGCTAACGGAGTATAGGTTGCAACACCGGGGATTATTGGACTTTTAAAACTTCACATTATAAGTTTCAGTCTCCTAGCTAACGGAGTATAGGTTGCAACAAATCTGCCAAATTCATCGAAGCCCGGGCTGTCATATATGAGTTTCAGTCTCCTACTTAGCGGAGTCTAGATTGCAACGCAATGTATAATTTATATAATAATGATTATTATATCATGTTTCAGTCTCCTACTTAGCAGAGT

>CP016379|9|3|722276-722753|CRT
ATTGGGGTCTCCTACTTAGCGGTGT	GTAGGTTGCAACGCTCGAATTAAACCAGATTTCCATTACGGACAGCAA
GTTTCAGTCTCCTACTTAACGGAGT	CTAGATTGCAACGCAAGTGGTTTTAGAGGCATCGAATGGGGTGCTTCGAA
GTTTCAGTCTCCTAGCTAACGGAGT	CTAGGTTGCAACATAGAGTGATCGAAGAGATCGCTCGGAATGATGAAGATGC
GTTTCAGTCTCCTAGCTAACGGAGT	ATAGGTTGCAACACCGGGGATTATTGGACTTTTAAAACTTCACATTATAA
GTTTCAGTCTCCTAGCTAACGGAGT	ATAGGTTGCAACAAATCTGCCAAATTCATCGAAGCCCGGGCTGTCATATATGA
GTTTCAGTCTCCTACTTAGCGGAGT	CTAGATTGCAACGCAATGTATAATTTATATAATAATGATTATTATATCAT
GTTTCAGTCTCCTACTTAGCAGAGT

>CP016379|9|5|722422-722615|PILER-CR
AAGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACATA	GAGTGATCGAAGAGATCGCTCGGAATGATGAAGAT
GCGTTTCAGTCTCCTAGCTAACGGAGTATAGGTTGCAACACC	GGGGATTATTGGACTTTTAAAACTTCACATTAT
AAGTTTCAGTCTCCTAGCTAACGGAGTATAGGTTGCAACAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_10

• CRISPR_ID: CP016379_10
• CRISPR_location: 723243-723735
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 6 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_10

Consensus_repeat	Method
GTTTCAGTCTCCTANNTAACGGAGTCTAGNTTGCAAC	CRT

spacers of CP016379_10

>10.1|723280|38|CP016379|CRT
GAAATTAGAAGTTTGCACACTTTTATAGTCGGTACCAC
>10.2|723355|38|CP016379|CRT
GAATATGAAGCTGGGGTATTAAATCAAGCACTTTATAT
>10.3|723430|40|CP016379|CRT
CATGAAAAATTCTTGGTTTTTTATCCCGGGATATATGGAC
>10.4|723507|42|CP016379|CRT
AAAAGAAAAAGGAATTAAGCCACAGGAAGTTTTAGCAAAATT
>10.5|723586|40|CP016379|CRT
GATATAGCAAAAATCAATATTACGTTTTGTTTTTTACACC
>10.6|723663|36|CP016379|CRT
AGGCACATACACTATCAGAGTCTCGGCCTCAGGTTA

CRISPR arrays and Neighbor proteins around CP016379_10

CRISPR arrays

The CRISPR arrays of CP016379_10

>merge|CP016379|10|723243-723735|CRT
GAAGAAGTCTCCTAACTAACGGAGTCTAGGTTGCAACGAAATTAGAAGTTTGCACACTTTTATAGTCGGTACCACGTTTCAGTCTCCTAGCTAACGGAGTCTAGGGCAACAAGAATATGAAGCTGGGGTATTAAATCAAGCACTTTATATGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACCATGAAAAATTCTTGGTTTTTTATCCCGGGATATATGGACGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACAAAAGAAAAAGGAATTAAGCCACAGGAAGTTTTAGCAAAATTGTTTCAGTCTCCTACTTAACGGAGTCTAGATTGCAACGATATAGCAAAAATCAATATTACGTTTTGTTTTTTACACCGTTTCAGTCTCCTACTTAACGGAGTCTAGATTGCAACAGGCACATACACTATCAGAGTCTCGGCCTCAGGTTAGTTTCAGTCTCCTACTTAACGGAGTTTACATTGCAAC

>CP016379|10|4|723243-723735|CRT
GAAGAAGTCTCCTAACTAACGGAGTCTAGGTTGCAAC	GAAATTAGAAGTTTGCACACTTTTATAGTCGGTACCAC
GTTTCAGTCTCCTAGCTAACGGAGTCTAGGGCAACAA	GAATATGAAGCTGGGGTATTAAATCAAGCACTTTATAT
GTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAAC	CATGAAAAATTCTTGGTTTTTTATCCCGGGATATATGGAC
GTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAAC	AAAAGAAAAAGGAATTAAGCCACAGGAAGTTTTAGCAAAATT
GTTTCAGTCTCCTACTTAACGGAGTCTAGATTGCAAC	GATATAGCAAAAATCAATATTACGTTTTGTTTTTTACACC
GTTTCAGTCTCCTACTTAACGGAGTCTAGATTGCAAC	AGGCACATACACTATCAGAGTCTCGGCCTCAGGTTA
GTTTCAGTCTCCTACTTAACGGAGTTTACATTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_11

• CRISPR_ID: CP016379_11
• CRISPR_location: 723745-724113
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 5 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_11

Consensus_repeat	Method
GTTTCAATTCCTTATAGGTAGGCTA	CRT
GTTTCAATTCCTTATAGGTAGGCTAGAAAC	PILER-CR

spacers of CP016379_11

>11.1|723770|44|CP016379|CRT
CAAACCCACCCTTCGGGTGGATTGTATAGCCATTCCTTTAGTAT
>11.2|723839|42|CP016379|CRT
AAAACTGGAGGTTTATACATCAGAGAACTGGAAGGAGTTTCT
>11.3|723906|40|CP016379|CRT
GAAACCTAAGCCACGAAGAAATATACGATGAAAGCTTCAT
>11.4|723971|42|CP016379|CRT
GAAACTCAATTTGTACGGCATCAAATTTGAGTACAAAAAGGA
>11.5|724038|46|CP016379|CRT
GAAACTTGATTATGGGACCATTAGGAAGATACGGAGCGTATTTATG
>11.6|723911|35|CP016379|PILER-CR
CTAAGCCACGAAGAAATATACGATGAAAGCTTCAT
>11.7|723976|37|CP016379|PILER-CR
TCAATTTGTACGGCATCAAATTTGAGTACAAAAAGGA
>11.8|724043|41|CP016379|PILER-CR
TTGATTATGGGACCATTAGGAAGATACGGAGCGTATTTATG

CRISPR arrays and Neighbor proteins around CP016379_11

CRISPR arrays

The CRISPR arrays of CP016379_11

>merge|CP016379|11|723745-724113|CRT,PILER-CR
TTGTCTGGACCTCATAGGTAGGCTACAAACCCACCCTTCGGGTGGATTGTATAGCCATTCCTTTAGTATGTTTCAATTCCTTCTAGGTAGGCTAAAAACTGGAGGTTTATACATCAGAGAACTGGAAGGAGTTTCTGTTTCAATTCCTTATAGGTAGGCTAGAAACCTAAGCCACGAAGAAATATACGATGAAAGCTTCATGTTTCAATTCCTTATAGGTAGGCTAGAAACTCAATTTGTACGGCATCAAATTTGAGTACAAAAAGGAGTTTCAATTCCTTATAGGTAGGCTAGAAACTTGATTATGGGACCATTAGGAAGATACGGAGCGTATTTATGGTTTCAATTCCTTATAGGTAGGCTAGAAAC

>CP016379|11|5|723745-724108|CRT
TTGTCTGGACCTCATAGGTAGGCTA	CAAACCCACCCTTCGGGTGGATTGTATAGCCATTCCTTTAGTAT
GTTTCAATTCCTTCTAGGTAGGCTA	AAAACTGGAGGTTTATACATCAGAGAACTGGAAGGAGTTTCT
GTTTCAATTCCTTATAGGTAGGCTA	GAAACCTAAGCCACGAAGAAATATACGATGAAAGCTTCAT
GTTTCAATTCCTTATAGGTAGGCTA	GAAACTCAATTTGTACGGCATCAAATTTGAGTACAAAAAGGA
GTTTCAATTCCTTATAGGTAGGCTA	GAAACTTGATTATGGGACCATTAGGAAGATACGGAGCGTATTTATG
GTTTCAATTCCTTATAGGTAGGCTA

>CP016379|11|6|723881-724113|PILER-CR
GTTTCAATTCCTTATAGGTAGGCTAGAAAC	CTAAGCCACGAAGAAATATACGATGAAAGCTTCAT
GTTTCAATTCCTTATAGGTAGGCTAGAAAC	TCAATTTGTACGGCATCAAATTTGAGTACAAAAAGGA
GTTTCAATTCCTTATAGGTAGGCTAGAAAC	TTGATTATGGGACCATTAGGAAGATACGGAGCGTATTTATG
GTTTCAATTCCTTATAGGTAGGCTAGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_12

• CRISPR_ID: CP016379_12
• CRISPR_location: 724671-724996
• CRISPR_type: TypeV-U3
• Repeat_type: ?
• Spacer_info: 4 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_12

Consensus_repeat	Method
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	CRISPRCasFinder
GTTTCAATCCTTGTTTTANTGGAACTTGCATTCAAAC	CRT
GTTTGAATGCAAGTTCCATTAAAACAAGGATTGAAAC	PILER-CR

spacers of CP016379_12

>12.1|724708|35|CP016379|CRISPRCasFinder,CRT
GTGTGATAGTTGAAATGAATAGTGAAATATGGAAA
>12.2|724780|36|CP016379|CRISPRCasFinder,CRT,PILER-CR
TCTCTTTTCTTAATTCTTTTAGACGATCTCCAAACA
>12.3|724853|35|CP016379|CRISPRCasFinder,CRT,PILER-CR
GTTCAAAGCCTCTCAGAAAGCCTCTCAGAAGCTTT
>12.4|724925|34|CP016379|CRISPRCasFinder,CRT,PILER-CR
AATACACCCTATCAAATACATCTTTCATTTAAGC

CRISPR arrays and Neighbor proteins around CP016379_12

CRISPR arrays

The CRISPR arrays of CP016379_12

>merge|CP016379|12|724671-724996|CRISPRCasFinder,CRT,PILER-CR
GTTTCACGTTTTGTTTTAGTGGGACTTGCATTCAAACGTGTGATAGTTGAAATGAATAGTGAAATATGGAAAGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACTCTCTTTTCTTAATTCTTTTAGACGATCTCCAAACAGTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACGTTCAAAGCCTCTCAGAAAGCCTCTCAGAAGCTTTGTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACAATACACCCTATCAAATACATCTTTCATTTAAGCGTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACC

>CP016379|12|6|724671-724996|CRISPRCasFinder
GTTTCACGTTTTGTTTTAGTGGGACTTGCATTCAAAC	GTGTGATAGTTGAAATGAATAGTGAAATATGGAAA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCTCTTTTCTTAATTCTTTTAGACGATCTCCAAACA
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	GTTCAAAGCCTCTCAGAAAGCCTCTCAGAAGCTTT
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	AATACACCCTATCAAATACATCTTTCATTTAAGC
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACC

>CP016379|12|6|724671-724995|CRT
GTTTCACGTTTTGTTTTAGTGGGACTTGCATTCAAAC	GTGTGATAGTTGAAATGAATAGTGAAATATGGAAA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCTCTTTTCTTAATTCTTTTAGACGATCTCCAAACA
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	GTTCAAAGCCTCTCAGAAAGCCTCTCAGAAGCTTT
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	AATACACCCTATCAAATACATCTTTCATTTAAGC
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC

>CP016379|12|7|724743-724995|PILER-CR
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCTCTTTTCTTAATTCTTTTAGACGATCTCCAAACA
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	GTTCAAAGCCTCTCAGAAAGCCTCTCAGAAGCTTT
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	AATACACCCTATCAAATACATCTTTCATTTAAGC
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl|CDD|143441
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72474.1|706415_708047_+|1-pyrroline-5-carboxylate-dehydrogenase
MSNAIYKIEKPANEPVLSYRPGSPEREELKAKLKELKSREIEIPLIIGGKEVKTGDFGECRMPHDHQHRLAVYHKAGPKEIEMAIEAAREAKKEWARMAWEDRIAIFRKAAELLAGPYRSLLNAATMLGQSKNVFQAEIDSACELIDFFRFNTYYATQIYKDQPYSPVGFWNRMEYRPLEGFVFAVTPFNFTSIAGNLPTSPAMLGNTVLWKPASSAIYSAYYIMKLLEEAGLPPGVINFIPGSGSKVGDYVLASPELAGIHFTGSTEVFKSMWRTVGENIEKYNTYPRIVGETGGKDFVFVHESAQVAPVVTALIRGAFEYQGQKCSAASRAYIPDNRWEEIKEELLAQISELKMGSPEDFTNFVNAVIDKNAYQSIKEYIDYAKAHEDAEILIGGNCDDSKGYFIEPTVILAKTPDFKTMREEIFGPVLTVYVYDADKYEETLHICDQTSPYGLTGSIFAQDRKAIVLAEDILVNAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSYLNLLRWVSPRAIKETFVPPVDYRYPFMEEE
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL

Crispr_ID: CP016379_13

• CRISPR_ID: CP016379_13
• CRISPR_location: 725914-726176
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_13

Consensus_repeat	Method
GTTTCAGTCTCCTACTTAGCGGAGTCTAGATTGCAACAA	PILER-CR

spacers of CP016379_13

>13.1|725953|33|CP016379|PILER-CR
AAAAACAGTAATAATAAAAATTGGGTTCACTGT
>13.2|726025|38|CP016379|PILER-CR
TAAATGAGTTTAAAAGAAAAGATCGTGATTATTGGTGA
>13.3|726102|36|CP016379|PILER-CR
AAATATAGACTTTGAGCAAAAAAGATTGAAATTTTT

CRISPR arrays and Neighbor proteins around CP016379_13

CRISPR arrays

The CRISPR arrays of CP016379_13

>merge|CP016379|13|725914-726176|PILER-CR
GTTTCAGTCTCCTACTTAGCGGAGTCTAGATTGCAACAAAAAAACAGTAATAATAAAAATTGGGTTCACTGTCTTTCAGTCTCCTACTTAGTGGAGTGTAGGTTGCAACAATAAATGAGTTTAAAAGAAAAGATCGTGATTATTGGTGAGTTTCAGTCTCCTACTTAGCGGAGTGTAGATTGCAACGAAAATATAGACTTTGAGCAAAAAAGATTGAAATTTTTGTTTCAGTCTCCTACTTAACGGAGTCCAGATTGCAACAA

>CP016379|13|8|725914-726176|PILER-CR
GTTTCAGTCTCCTACTTAGCGGAGTCTAGATTGCAACAA	AAAAACAGTAATAATAAAAATTGGGTTCACTGT
CTTTCAGTCTCCTACTTAGTGGAGTGTAGGTTGCAACAA	TAAATGAGTTTAAAAGAAAAGATCGTGATTATTGGTGA
GTTTCAGTCTCCTACTTAGCGGAGTGTAGATTGCAACGA	AAATATAGACTTTGAGCAAAAAAGATTGAAATTTTT
GTTTCAGTCTCCTACTTAACGGAGTCCAGATTGCAACAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS

Crispr_ID: CP016379_14

• CRISPR_ID: CP016379_14
• CRISPR_location: 726760-726945
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_14

Consensus_repeat	Method
AGTTTCAGTCTCCTACTTAACGGAGTCTAGATTGCAA	PILER-CR

spacers of CP016379_14

>14.1|726797|38|CP016379|PILER-CR
CCCTCTTTAATGGATGATTGGTGGTGGGACAAAGAGAA
>14.2|726872|39|CP016379|PILER-CR
CAAAGCGAACTGGTGGAAAACGGTGGCAGCAAGACTGTC

CRISPR arrays and Neighbor proteins around CP016379_14

CRISPR arrays

The CRISPR arrays of CP016379_14

>merge|CP016379|14|726760-726945|PILER-CR
TTTCAGTCTCCTACTTAGCGGAGTCTAGATTGCAACCCTCTTTAATGGATGATTGGTGGTGGGACAAAGAGAAAGTTTCAGTCTCCTAGCTAACGGAGTCTAGATTGCAACAAAGCGAACTGGTGGAAAACGGTGGCAGCAAGACTGTCAGTTTCAGTCTCCTACTTAACGGAGTCTAGATTGTAA

>CP016379|14|9|726760-726945|PILER-CR
TTTCAGTCTCCTACTTAGCGGAGTCTAGATTGCAACC	CTCTTTAATGGATGATTGGTGGTGGGACAAAGAGAAAG
TTTCAGTCTCCTAGCTAACGGAGTCTAGATTGCAACA	AAGCGAACTGGTGGAAAACGGTGGCAGCAAGACTGTCAG
TTTCAGTCTCCTACTTAACGGAGTCTAGATTGTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS

Crispr_ID: CP016379_15

• CRISPR_ID: CP016379_15
• CRISPR_location: 727025-727398
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 5 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_15

Consensus_repeat	Method
GTTTCAATTCCTTNTAGGTAGGCTA	CRT
GTTTCAATTCCTTATAGGTAGGCTACAAAC	PILER-CR

spacers of CP016379_15

>15.1|727050|43|CP016379|CRT
CAAACAAAAGGGTAAAAAATGATGTTTACCCAAACGTAAAGGT
>15.2|727118|46|CP016379|CRT
CAAACGTGTGGAGAACACACCCGATTTCAAAACTTTTCAGGGAAAG
>15.3|727189|44|CP016379|CRT
GAAACATTTGTAGCTTTGCGGGATGGTCAAATTACTCAATTTGA
>15.4|727258|44|CP016379|CRT
GAAACCAGATTATTAGCTATGCCTAAAGAAGTGTTCTTTAAAAA
>15.5|727327|42|CP016379|CRT
CAAACTAAAAGAAATAGAATTTAAAGAATTTTACACAGAAAA
>15.6|727123|41|CP016379|PILER-CR
GTGTGGAGAACACACCCGATTTCAAAACTTTTCAGGGAAAG
>15.7|727194|39|CP016379|PILER-CR
ATTTGTAGCTTTGCGGGATGGTCAAATTACTCAATTTGA
>15.8|727263|39|CP016379|PILER-CR
CAGATTATTAGCTATGCCTAAAGAAGTGTTCTTTAAAAA
>15.9|727332|37|CP016379|PILER-CR
TAAAAGAAATAGAATTTAAAGAATTTTACACAGAAAA

CRISPR arrays and Neighbor proteins around CP016379_15

CRISPR arrays

The CRISPR arrays of CP016379_15

>merge|CP016379|15|727025-727398|CRT,PILER-CR
GTTTCAATTTCTTTTAGGTAGACTACAAACAAAAGGGTAAAAAATGATGTTTACCCAAACGTAAAGGTGTTTCAATTCCTCATAGGTAGGCTACAAACGTGTGGAGAACACACCCGATTTCAAAACTTTTCAGGGAAAGGTTTCAATTCCTTATAGGTAGGCTAGAAACATTTGTAGCTTTGCGGGATGGTCAAATTACTCAATTTGAGTTTCAATTCCTTATAGGTAGGCTAGAAACCAGATTATTAGCTATGCCTAAAGAAGTGTTCTTTAAAAAGTTTCAATTCCTTATAGGTAGGCTACAAACTAAAAGAAATAGAATTTAAAGAATTTTACACAGAAAAGTTTCAATTCCTTCTAGGTAGGCTACAAAC

>CP016379|15|7|727025-727393|CRT
GTTTCAATTTCTTTTAGGTAGACTA	CAAACAAAAGGGTAAAAAATGATGTTTACCCAAACGTAAAGGT
GTTTCAATTCCTCATAGGTAGGCTA	CAAACGTGTGGAGAACACACCCGATTTCAAAACTTTTCAGGGAAAG
GTTTCAATTCCTTATAGGTAGGCTA	GAAACATTTGTAGCTTTGCGGGATGGTCAAATTACTCAATTTGA
GTTTCAATTCCTTATAGGTAGGCTA	GAAACCAGATTATTAGCTATGCCTAAAGAAGTGTTCTTTAAAAA
GTTTCAATTCCTTATAGGTAGGCTA	CAAACTAAAAGAAATAGAATTTAAAGAATTTTACACAGAAAA
GTTTCAATTCCTTCTAGGTAGGCTA

>CP016379|15|10|727093-727398|PILER-CR
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GTGTGGAGAACACACCCGATTTCAAAACTTTTCAGGGAAAG
GTTTCAATTCCTTATAGGTAGGCTAGAAAC	ATTTGTAGCTTTGCGGGATGGTCAAATTACTCAATTTGA
GTTTCAATTCCTTATAGGTAGGCTAGAAAC	CAGATTATTAGCTATGCCTAAAGAAGTGTTCTTTAAAAA
GTTTCAATTCCTTATAGGTAGGCTACAAAC	TAAAAGAAATAGAATTTAAAGAATTTTACACAGAAAA
GTTTCAATTCCTTCTAGGTAGGCTACAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	unknown	unknown	gnl|CDD|223910
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.96818e-55
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72475.1|708239_710174_+|hypothetical-protein
MRHISRLGAKLVGIVLVFIIIPLTMTYFITQKEVKTILTEKIKVINKKNAENVFTEVEEFISAAESLATELSKSETIGMFISGMGDFIAMDLEEVRNKYPWIVRFEIAAEDGTYTVYPEKEYEDDYDMRKTLWYQRAKKENKLIWIPAINKSDQFRLAIPIRYTYKDEIAGVFSLLIDMGQFTEIMRQYSINEGSMLMINQTGAVLASDISTEVDDEYFDQYSFFEKFFQTDEILFGTYIYAGQSRLTFTKHIPELKSILLLQLSEKKAFADVDRLLSKFKWIGTVTLLVVIVVFTIVTRLWITNRIIHLAESARTIADGNLQKLIQLKGNDEIGILARSFNEMTLNLRNLIQDILKNAKTVAESSQRIFESAEVSNQVSEQVASSIQQVAAGAENQSRFIEQMNEKLVQLNHYIEGLTKTNKSVHDIAQTTQSKANQGAESMKRVVEQMSVIQKSIAESNRVISGMTRAADEISNFVNIIDNIANQTNLLALNAAIEAARAGEEGRGFAVVAKEIRSLAEEVSVSAGKIRELVESTQNFSNQASTAMEEGIKQIGFGQKVVNESGEIFSEIIESFERTLSAIQKVDEMISNLSENMVQIIEGQRILRVLLKRMPHLLKKFQLQRKNRQQLWMRLHSWLNLLKI
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL

Crispr_ID: CP016379_16

• CRISPR_ID: CP016379_16
• CRISPR_location: 728065-728625
• CRISPR_type: TypeV-U3
• Repeat_type: ?
• Spacer_info: 7 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_16

Consensus_repeat	Method
GTTTGAATGCAAGTTCCACTAAAACAAGGATTGAAAC	PILER-CR
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	CRISPRCasFinder
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	CRT

spacers of CP016379_16

>16.1|728102|39|CP016379|PILER-CR,CRISPRCasFinder,CRT
TCGCGCGGGCTTCAAACCAGTAGGCTGGTGTGAAATAGA
>16.2|728178|37|CP016379|PILER-CR,CRISPRCasFinder,CRT
TGGAGCTATTTTGATGGCAGAGGAAGGGCTTGTTGAG
>16.3|728252|38|CP016379|PILER-CR,CRISPRCasFinder,CRT
ACCATTGAAGAGTTAGACGAACTAAAAAAGGATGGTAC
>16.4|728327|36|CP016379|PILER-CR,CRISPRCasFinder,CRT
ATTAGAAGAACCATACATCAAAGATATTGACGGTGT
>16.5|728400|41|CP016379|PILER-CR,CRISPRCasFinder,CRT
AATGCCTGTTTTTCCTTTCGCACTTATCGCAGTTTTGAATA
>16.6|728478|35|CP016379|PILER-CR,CRISPRCasFinder,CRT
TCTAACGAGATTGAACATGGAAATATACTATACTT
>16.7|728550|38|CP016379|PILER-CR,CRISPRCasFinder,CRT
CCGGTATCCCTCCGGAACACCGTTCTCAAGCAGTATTT

CRISPR arrays and Neighbor proteins around CP016379_16

CRISPR arrays

The CRISPR arrays of CP016379_16

>merge|CP016379|16|728065-728625|PILER-CR,CRISPRCasFinder,CRT
GTTTCACGCCTTGTTTTAGTGGAACTTGCATTCAAACTCGCGCGGGCTTCAAACCAGTAGGCTGGTGTGAAATAGAGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACTGGAGCTATTTTGATGGCAGAGGAAGGGCTTGTTGAGGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACACCATTGAAGAGTTAGACGAACTAAAAAAGGATGGTACGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACATTAGAAGAACCATACATCAAAGATATTGACGGTGTGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACAATGCCTGTTTTTCCTTTCGCACTTATCGCAGTTTTGAATAGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACTCTAACGAGATTGAACATGGAAATATACTATACTTGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAGCCCGGTATCCCTCCGGAACACCGTTCTCAAGCAGTATTTGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACC

>CP016379|16|11|728065-728624|PILER-CR
GTTTCACGCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCGCGCGGGCTTCAAACCAGTAGGCTGGTGTGAAATAGA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TGGAGCTATTTTGATGGCAGAGGAAGGGCTTGTTGAG
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	ACCATTGAAGAGTTAGACGAACTAAAAAAGGATGGTAC
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	ATTAGAAGAACCATACATCAAAGATATTGACGGTGT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	AATGCCTGTTTTTCCTTTCGCACTTATCGCAGTTTTGAATA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCTAACGAGATTGAACATGGAAATATACTATACTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAGC	CCGGTATCCCTCCGGAACACCGTTCTCAAGCAGTATTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC

>CP016379|16|7|728065-728625|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCGCGCGGGCTTCAAACCAGTAGGCTGGTGTGAAATAGA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TGGAGCTATTTTGATGGCAGAGGAAGGGCTTGTTGAG
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	ACCATTGAAGAGTTAGACGAACTAAAAAAGGATGGTAC
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	ATTAGAAGAACCATACATCAAAGATATTGACGGTGT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	AATGCCTGTTTTTCCTTTCGCACTTATCGCAGTTTTGAATA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCTAACGAGATTGAACATGGAAATATACTATACTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAGC	CCGGTATCCCTCCGGAACACCGTTCTCAAGCAGTATTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACC

>CP016379|16|8|728065-728624|CRT
GTTTCACGCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCGCGCGGGCTTCAAACCAGTAGGCTGGTGTGAAATAGA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TGGAGCTATTTTGATGGCAGAGGAAGGGCTTGTTGAG
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	ACCATTGAAGAGTTAGACGAACTAAAAAAGGATGGTAC
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	ATTAGAAGAACCATACATCAAAGATATTGACGGTGT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	AATGCCTGTTTTTCCTTTCGCACTTATCGCAGTTTTGAATA
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC	TCTAACGAGATTGAACATGGAAATATACTATACTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAGC	CCGGTATCCCTCCGGAACACCGTTCTCAAGCAGTATTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL

Crispr_ID: CP016379_17

• CRISPR_ID: CP016379_17
• CRISPR_location: 729266-729661
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 5 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_17

Consensus_repeat	Method
TTTCAGTCTCCTACTTA	PILER-CR

spacers of CP016379_17

>17.1|729283|61|CP016379|PILER-CR
ACGGAGTGTAGGTTGCAACGAACGAAGACGAATAAGGAATGCCTGCAGAGCATATATCCAG
>17.2|729361|58|CP016379|PILER-CR
GTGGAGTCTAGGTTGCAACACCATTCGCGGAGTAGGAGCTGTCGCGAAATTTGTTTTC
>17.3|729436|59|CP016379|PILER-CR
GCGGAGTCTAGGTTGCAACATGCTATACCTATGTGTTTGAGATCTATCGAGTTTTAAAG
>17.4|729512|57|CP016379|PILER-CR
ACGGAGTCTAGGTTGCAACATATTATTGAACTATTAGAAGAATATTTTGAAAAAATG
>17.5|729586|63|CP016379|PILER-CR
GCTAACGGAGTGTAGGTTGCAACGGCAAACTGTATTGGACAGATGGAGAAATTCCAACAGTTG

CRISPR arrays and Neighbor proteins around CP016379_17

CRISPR arrays

The CRISPR arrays of CP016379_17

>merge|CP016379|17|729266-729661|PILER-CR
TTTCAGTCTCCTGCTTAACGGAGTGTAGGTTGCAACGAACGAAGACGAATAAGGAATGCCTGCAGAGCATATATCCAGTTTCAGTCTCCTACTTAGTGGAGTCTAGGTTGCAACACCATTCGCGGAGTAGGAGCTGTCGCGAAATTTGTTTTCTTTCAGTCTCCTACTTAGCGGAGTCTAGGTTGCAACATGCTATACCTATGTGTTTGAGATCTATCGAGTTTTAAAGTTTCAGTCTCCTACTTAACGGAGTCTAGGTTGCAACATATTATTGAACTATTAGAAGAATATTTTGAAAAAATGTTTCAGTCTCCTAGCTAACGGAGTGTAGGTTGCAACGGCAAACTGTATTGGACAGATGGAGAAATTCCAACAGTTGTTTCAGTCTCCTACTTA

>CP016379|17|12|729266-729661|PILER-CR
TTTCAGTCTCCTGCTTA	ACGGAGTGTAGGTTGCAACGAACGAAGACGAATAAGGAATGCCTGCAGAGCATATATCCAG
TTTCAGTCTCCTACTTA	GTGGAGTCTAGGTTGCAACACCATTCGCGGAGTAGGAGCTGTCGCGAAATTTGTTTTC
TTTCAGTCTCCTACTTA	GCGGAGTCTAGGTTGCAACATGCTATACCTATGTGTTTGAGATCTATCGAGTTTTAAAG
TTTCAGTCTCCTACTTA	ACGGAGTCTAGGTTGCAACATATTATTGAACTATTAGAAGAATATTTTGAAAAAATG
TTTCAGTCTCCTAGCTA	ACGGAGTGTAGGTTGCAACGGCAAACTGTATTGGACAGATGGAGAAATTCCAACAGTTGTTTC
AGTCTCCTACTTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL

Crispr_ID: CP016379_18

• CRISPR_ID: CP016379_18
• CRISPR_location: 730423-730531
• CRISPR_type: TypeV-U3
• Repeat_type: ?
• Spacer_info: 1 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_18

Consensus_repeat	Method
GTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAAC	CRISPRCasFinder

spacers of CP016379_18

>18.1|730460|35|CP016379|CRISPRCasFinder
TTTGTCAACCCGCCTGTTAGTATAGGTGGGTTTTT

CRISPR arrays and Neighbor proteins around CP016379_18

CRISPR arrays

The CRISPR arrays of CP016379_18

>merge|CP016379|18|730423-730531|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGCGGAACTATCATTCAAACTTTGTCAACCCGCCTGTTAGTATAGGTGGGTTTTTGTTTCAATCCTTGTTTTAGTGGAACTTGCGTTGCTTA

>CP016379|18|8|730423-730531|CRISPRCasFinder
GTTTCACGCCTTGTTTTAGCGGAACTATCATTCAAAC	TTTGTCAACCCGCCTGTTAGTATAGGTGGGTTTTT
GTTTCAATCCTTGTTTTAGTGGAACTTGCGTTGCTTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL

Crispr_ID: CP016379_19

• CRISPR_ID: CP016379_19
• CRISPR_location: 730609-730913
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 4 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_19

Consensus_repeat	Method
GTTTCAATTCCTTCTAGGTAGGCTACAAAC	PILER-CR

spacers of CP016379_19

>19.1|730640|37|CP016379|PILER-CR
TTATCGAAAATGGCCAATTGAGTGGGGAGTTAGTCGA
>19.2|730708|37|CP016379|PILER-CR
AAGAAAATTTAGAAGACCTAACTATTCCATTTGACCC
>19.3|730776|41|CP016379|PILER-CR
GGGACGTATTCACTCTCAATATCATGTTCTGGATATCAAGA
>19.4|730848|39|CP016379|PILER-CR
TTTTAAATAAAATTAAAGAATGGCCGGTTGATTATGTGT

CRISPR arrays and Neighbor proteins around CP016379_19

CRISPR arrays

The CRISPR arrays of CP016379_19

>merge|CP016379|19|730609-730913|PILER-CR
GTTTCAATTCCTTCTAGGTAGGCTACAAACTTATCGAAAATGGCCAATTGAGTGGGGAGTTAGTCGAGTTTCAATTCCTTCTAGGTAGGCTACAAACAAGAAAATTTAGAAGACCTAACTATTCCATTTGACCCGTTTCAATTCCTTCTAGGTAGGCTAGAAACGGGACGTATTCACTCTCAATATCATGTTCTGGATATCAAGAGTTTCAATTCCTTAGTAGGTAGGCTACAAACTTTTAAATAAAATTAAAGAATGGCCGGTTGATTATGTGTGTTTCAATTCCTTATAGGTAGGCTACAAAC

>CP016379|19|13|730609-730913|PILER-CR
GTTTCAATTCCTTCTAGGTAGGCTACAAACT	TATCGAAAATGGCCAATTGAGTGGGGAGTTAGTCGAG
TTTCAATTCCTTCTAGGTAGGCTACAAACAA	GAAAATTTAGAAGACCTAACTATTCCATTTGACCCGT
TTCAATTCCTTCTAGGTAGGCTAGAAACGGG	ACGTATTCACTCTCAATATCATGTTCTGGATATCAAGAGTT
TCAATTCCTTAGTAGGTAGGCTACAAACTTT	TAAATAAAATTAAAGAATGGCCGGTTGATTATGTGTGTT
TCAATTCCTTATAGGTAGGCTACAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	unknown	unknown	gnl|CDD|227029
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	unknown	unknown	gnl|CDD|271189
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	unknown	unknown	gnl|CDD|239070
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component	gnl|CDD|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.84479e-25
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.0948e-43
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58	gnl|CDD|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.91159e-114
CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.21361e-19
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR74809.1|713423_714572_-|hypothetical-protein
MAHVEKRGKNSYRIIISLGKDPVTGKYRYYRETIKAKNKREAEKKAIEIEARILKGDYIKPDNITVEEYLNQWLENSSFNLKETTLNNYKIIINAHIIPELGKISLQKLQPIHIQNYILKKLKSGRRDGKGGLSNRSVRYHYTILREALDAAVKLQLIDKNPAVAIEPPKVEKKEMKALNQKEIDKLLETALEMYDYTTYAIIFIAIYTGMRRGEILGLSWDHVDLDDASLRVEQTLLKGPEGSKLYTPKTEQSRRTIFLTKTTVEVLEKLKKEQAINKLKLGPAYNNEYNLVFVNADGSIITPDAFKNRFTRIRKKAGLNNIRFHDLRHTHATMMLQAGISHKEAAERLGHSTITTTVDLYTHVTEPLKRRVVDKLERMTR
>CP016379.1|AZR72478.1|712327_713008_+|hypothetical-protein
MKGQERFRVELGRLQDYCQEAIQIFGDEEDSINKIQEVCSNLRSFMGRLFAIAEELNEKSRKGVTYSEGEASESNTLFDCIKSFRRRNVYYDLLNFEEAVYELRRVVDESTDPHVIASAYNGLGHIYAIRKMYAPAIYYFNKVVEFYPGNSDGYFNLGAVYFNLGFYDEARYYFQQAIYHHTDDWEAYFHLGRTFEKLGELDTAVYYIQKAREIKYSQPAVVMVTR
>CP016379.1|AZR72477.1|711010_711958_+|peptidase-S58
MEEIKIGHAEDKEGFTGCTVIICPKGAVAGVDVRGSAPGTRETDLLNPVMMVEKVHAILLAGGSAFGLAAADGVMKYLEEKGIGFDVGVTRVPIVPGAVIFDLGLGDYRARPDCEMGYQACLNAVENNSAEGCVGAGIGASVGKIKGMEWATKSGLGMAHLKVGEVEVSALVVVNALGDVIDPETGKIIAGVRNESGFESTEEIFRVNYKKVYKFTNTTIGVVFTNAKLNKAQAKKLAQVSHQGLVRTIRPIHTQFDGDTLFALSYGDLKVDFTLLGIMAADAVSQAVVRAVKTAVSMGGLPAMKDLMGVLKDDN
>CP016379.1|AZR72476.1|710490_711024_+|ECF-transporter-S-component
MKLKTRDMVISGILGGIAIFLGQTGFGFIPLPTGINATIMHLPVIIGAVLEGPVVGTLVGLIFGLFSWIQARNPFFADPTISVLPRLFIGIITYFSYQSLKRFNDHVAMAVAGVIGSLTNTVLVLGMIFLKGYMPFDAVVPIAFIHGIPEAIVAAIVTYFVCLGVKRARELKFDGGN
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL

Crispr_ID: CP016379_20

• CRISPR_ID: CP016379_20
• CRISPR_location: 734951-735708
• CRISPR_type: TypeV-U3
• Repeat_type: ?:I-B
• Spacer_info: 10 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_20

Consensus_repeat	Method
TTCCATTAAAACAAGGATTGAAAC	PILER-CR
GTTTCAATCCTTGTTTTANTGGAA	CRT

spacers of CP016379_20

>20.1|734976|51|CP016379|PILER-CR
CTTGCATTCAAACAACTACATTGAAAACTGCAAAGTGGATCCGCCATTCGA
>20.2|735052|48|CP016379|PILER-CR
TTTGGATTATGACGAGTTTAGGCCAGATGGTACGTTAAACCCAGAAGG
>20.3|735125|50|CP016379|PILER-CR
CTTGCATTCAAACTCTGGGCAGAAGAGCTGAAAAATGCAAAAGGCGCAGT
>20.4|735200|48|CP016379|PILER-CR
TTTGGATTATGACTTTAATGATTTTTTACATTATTGCATTCAATGGAA
>20.5|735273|50|CP016379|PILER-CR
CTATCATTCAAACATATGAAGTTAACTGTAGCCCTTCCCCCTAAAAAAAT
>20.6|735348|48|CP016379|PILER-CR
CTATCATTCAAACTTAAATATTTTAGAACAATGGTATAATCAAGGAGT
>20.7|735421|49|CP016379|PILER-CR
CTTGCATTCAAACTTGACAATGATGAAGGTCAAAGAATCGAATATGCTA
>20.8|735495|48|CP016379|PILER-CR
CTATCATTCAAACCATAAGAATTATTATCAAATTCTAAGAAGTATTAG
>20.9|735568|50|CP016379|PILER-CR
CTTGCATTCAAACAATGATCTTGCTTCTCTATATATAGAAACTGGAGATT
>20.10|735643|51|CP016379|PILER-CR
CTTGCATTCAAACAATAGTTTTCCCCAGACCTACACTACTAATCTTTTTCA
>20.11|734975|51|CP016379|CRT
CTTGCATTCAAACAACTACATTGAAAACTGCAAAGTGGATCCGCCATTCGA
>20.12|735050|48|CP016379|CRT
TTTGGATTATGACGAGTTTAGGCCAGATGGTACGTTAAACCCAGAAGG
>20.13|735122|50|CP016379|CRT
CTTGCATTCAAACTCTGGGCAGAAGAGCTGAAAAATGCAAAAGGCGCAGT
>20.14|735196|48|CP016379|CRT
TTTGGATTATGACTTTAATGATTTTTTACATTATTGCATTCAATGGAA
>20.15|735268|50|CP016379|CRT
CTATCATTCAAACATATGAAGTTAACTGTAGCCCTTCCCCCTAAAAAAAT
>20.16|735342|49|CP016379|CRT
ACTATCATTCAAACTTAAATATTTTAGAACAATGGTATAATCAAGGAGT
>20.17|735415|49|CP016379|CRT
CTTGCATTCAAACTTGACAATGATGAAGGTCAAAGAATCGAATATGCTA
>20.18|735488|48|CP016379|CRT
CTATCATTCAAACCATAAGAATTATTATCAAATTCTAAGAAGTATTAG
>20.19|735560|50|CP016379|CRT
CTTGCATTCAAACAATGATCTTGCTTCTCTATATATAGAAACTGGAGATT
>20.20|735634|51|CP016379|CRT
CTTGCATTCAAACAATAGTTTTCCCCAGACCTACACTACTAATCTTTTTCA

CRISPR arrays and Neighbor proteins around CP016379_20

CRISPR arrays

The CRISPR arrays of CP016379_20

>merge|CP016379|20|734951-735708|PILER-CR,CRT
GTTTCACGCCTTGTTTTAGTGGAACTTGCATTCAAACAACTACATTGAAAACTGCAAAGTGGATCCGCCATTCGAGTTTCAATTCTTGTTTTAATGGAATTTGGATTATGACGAGTTTAGGCCAGATGGTACGTTAAACCCAGAAGGGTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACTCTGGGCAGAAGAGCTGAAAAATGCAAAAGGCGCAGTGTTTCAATCCTTGTTTTAATGGAATTTGGATTATGACTTTAATGATTTTTTACATTATTGCATTCAATGGAAGTTTCAATCCTTGTTTTAGTGGAACTATCATTCAAACATATGAAGTTAACTGTAGCCCTTCCCCCTAAAAAAATGTTTCAATCCTTGGTTTTAGTGGAACTATCATTCAAACTTAAATATTTTAGAACAATGGTATAATCAAGGAGTGTTTCAATCCTTGTTTTAGTGGAACTTGCATTCAAACTTGACAATGATGAAGGTCAAAGAATCGAATATGCTAGTTTCAATCCTTGTTTTAGTGGAACTATCATTCAAACCATAAGAATTATTATCAAATTCTAAGAAGTATTAGGTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACAATGATCTTGCTTCTCTATATATAGAAACTGGAGATTGTTTCAATCCTTGTTTTAATGGAACTTGCATTCAAACAATAGTTTTCCCCAGACCTACACTACTAATCTTTTTCAGTTTCAATCCTTGTTTTAATGGAA

>CP016379|20|14|734951-735708|PILER-CR
GTTTCACGCCTTGTTTTAGTGGAAC	TTGCATTCAAACAACTACATTGAAAACTGCAAAGTGGATCCGCCATTCGAG
TTTCAATTCTTGTTTTAATGGAATT	TGGATTATGACGAGTTTAGGCCAGATGGTACGTTAAACCCAGAAGGGT
TTCAATCCTTGTTTTAATGGAACTT	GCATTCAAACTCTGGGCAGAAGAGCTGAAAAATGCAAAAGGCGCAGTGTT
TCAATCCTTGTTTTAATGGAATTTG	GATTATGACTTTAATGATTTTTTACATTATTGCATTCAATGGAAGTTT
CAATCCTTGTTTTAGTGGAACTATC	ATTCAAACATATGAAGTTAACTGTAGCCCTTCCCCCTAAAAAAATGTTTC
AATCCTTGGTTTTAGTGGAACTATC	ATTCAAACTTAAATATTTTAGAACAATGGTATAATCAAGGAGTGTTTC
AATCCTTGTTTTAGTGGAACTTGCA	TTCAAACTTGACAATGATGAAGGTCAAAGAATCGAATATGCTAGTTTCA
ATCCTTGTTTTAGTGGAACTATCAT	TCAAACCATAAGAATTATTATCAAATTCTAAGAAGTATTAGGTTTCAA
TCCTTGTTTTAATGGAACTTGCATT	CAAACAATGATCTTGCTTCTCTATATATAGAAACTGGAGATTGTTTCAAT
CCTTGTTTTAATGGAACTTGCATTC	AAACAATAGTTTTCCCCAGACCTACACTACTAATCTTTTTCAGTTTCAATC
CTTGTTTTAATGGAA

>CP016379|20|9|734951-735708|CRT
GTTTCACGCCTTGTTTTAGTGGAA	CTTGCATTCAAACAACTACATTGAAAACTGCAAAGTGGATCCGCCATTCGA
GTTTCAATTCTTGTTTTAATGGAA	TTTGGATTATGACGAGTTTAGGCCAGATGGTACGTTAAACCCAGAAGG
GTTTCAATCCTTGTTTTAATGGAA	CTTGCATTCAAACTCTGGGCAGAAGAGCTGAAAAATGCAAAAGGCGCAGT
GTTTCAATCCTTGTTTTAATGGAA	TTTGGATTATGACTTTAATGATTTTTTACATTATTGCATTCAATGGAA
GTTTCAATCCTTGTTTTAGTGGAA	CTATCATTCAAACATATGAAGTTAACTGTAGCCCTTCCCCCTAAAAAAAT
GTTTCAATCCTTGGTTTTAGTGGA	ACTATCATTCAAACTTAAATATTTTAGAACAATGGTATAATCAAGGAGT
GTTTCAATCCTTGTTTTAGTGGAA	CTTGCATTCAAACTTGACAATGATGAAGGTCAAAGAATCGAATATGCTA
GTTTCAATCCTTGTTTTAGTGGAA	CTATCATTCAAACCATAAGAATTATTATCAAATTCTAAGAAGTATTAG
GTTTCAATCCTTGTTTTAATGGAA	CTTGCATTCAAACAATGATCTTGCTTCTCTATATATAGAAACTGGAGATT
GTTTCAATCCTTGTTTTAATGGAA	CTTGCATTCAAACAATAGTTTTCCCCAGACCTACACTACTAATCTTTTTCA
GTTTCAATCCTTGTTTTAATGGAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	unknown	unknown	gnl|CDD|212669
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	unknown	unknown	gnl|CDD|378935
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.15039e-13
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	3.50923e-70
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.15737e-13
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72479.1|714996_715593_+|hypothetical-protein
MKARDIDIRYVLHEKLNKQYGNDEDTVILDELVVCQGEACVDVAVINGTIIGYEIKSERDSLDRLPNQINAYNKVFDIVSIITGNCHLDKISSIVPDWWGIYLAISTETGLEIKQVRSPKPNKNVEAFALAQFLWREEILNLLSKYNLDKGIKRLPKFKLWPYIAENIPLDELKEYVRSCLKSRKELRALKNLKSNTV
>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL
>CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein
MPGVPRKRLREIRQTKYTLEEFAKLVHSSPTHLSDIENGKRDPSPELASAICRILGRSFSELFPDLRENYIKKSALLLSLATQ
>CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein
MRNKRKETMTAQELADLLGIKSVQTVYKLLNEGKIPGVKVGHQWVIPTQAILDWLYVAALGSQKRILEHIGVDFGELMDWIAKLRHYENCSNLDNLVKMPEFGSIKEEVVNLR
>CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein
MSKNIAVDVGFGFVKATDGNKEVIFPSVVGEGREIRYKPGVTINNDAIKNLFAEVDGEKYFVGDLATRQSEFLQSTLSGDRTNSIEYDVLFKTACALLNNGSTEVNIVTGLPVNEFTQYKNTLEKMLLRIHKIKLNDISYSFEIKRAKIIPQPFGTVFNLLLDDQGEIQKREYVNMKIGVIDIGFRTTDFIVVDCLEFVDKLSSSTTVALSSAYKLVGHSLNERFGINKPIYQLDKFIRTGFIPYKGQQMDIRELVGKAFALTTNNIISEVSSLWNIWELDQIIITGGGGVELYAYLKAHIDNCVLVNEGQFSNVKGYLKLANRSFR
>CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein
MVTISIRLRPGKDNDILQWWESLDKGERSGIVRSILRSYINQEDQSQQRVSRLNFGVKKENLEDLGDIEFRMDFPASENEDDNEIDKKVDLLVDQF

Crispr_ID: CP016379_21

• CRISPR_ID: CP016379_21
• CRISPR_location: 737299-738022
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 9 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_21

Consensus_repeat	Method
TTTCAGTCTCCTANNTANCGGAGTCTAGNTTGCAAC	CRT
TTTCAGTCTCCTACTTAACGGAGT-TAAGTTGCA	PILER-CR
GTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACA	PILER-CR

spacers of CP016379_21

>21.1|737335|41|CP016379|CRT
ACCAGTGGGGACTGGCGGTGGATCTCGTGGTTAGGAAGCAT
>21.2|737412|41|CP016379|CRT
ACGGCGGGCGGGACTTCGTGTATATGAGCAAAGAGCAGATG
>21.3|737489|39|CP016379|CRT
ACTCAAGGAACTGATACGATAGAATTTAAAGCTACGTTG
>21.4|737564|37|CP016379|CRT
AGAAGAAATTGGATGGGATAAGGAATATAAGCTTTTC
>21.5|737637|40|CP016379|CRT
ATTCTCCAGAACCAGACACATGCTTTTCGTGCCAAACCAG
>21.6|737713|43|CP016379|CRT
GATGATGTATTACTGTCAAGGAAAGTCGATTTCTCAAATAGCG
>21.7|737792|40|CP016379|CRT
AAACAGCTGAGGAGTACATGAGAGAAAATGATTCATTCAG
>21.8|737868|43|CP016379|CRT
TCAGCAAGAAGAATCATTATCCCGAAGAGGGCCCTTTTGGAGG
>21.9|737947|40|CP016379|CRT
TTACTTTGACTATCCATCAAGATACGCATCTGATGCAAAG
>21.10|737410|43|CP016379|PILER-CR
ACACGGCGGGCGGGACTTCGTGTATATGAGCAAAGAGCAGATG
>21.11|737487|58|CP016379|PILER-CR
GTGAAGTCTACATTGCAACACTCAAGGAACTGATACGATAGAATTTAAAGCTACGTTG
>21.12|737639|38|CP016379|PILER-CR
TTCTCCAGAACCAGACACATGCTTTTCGTGCCAAACCA
>21.13|737715|41|CP016379|PILER-CR
ATGATGTATTACTGTCAAGGAAAGTCGATTTCTCAAATAGC

CRISPR arrays and Neighbor proteins around CP016379_21

CRISPR arrays

The CRISPR arrays of CP016379_21

>merge|CP016379|21|737299-738022|CRT,PILER-CR,PILER-CR
TTTCGGTCTTCTGCTTATCTGAGTTAAGTTGCAACCACCAGTGGGGACTGGCGGTGGATCTCGTGGTTAGGAAGCATTTTCAGTTTCCTACTTAACGGAGTATAGGTTGCAACACGGCGGGCGGGACTTCGTGTATATGAGCAAAGAGCAGATGTTTCAGTCTCCTACTTAGTGAAGTCTACATTGCAACACTCAAGGAACTGATACGATAGAATTTAAAGCTACGTTGTTTCAGTCTCCTACTTAACGGAGTTAAGTTGCAATCAGAAGAAATTGGATGGGATAAGGAATATAAGCTTTTCTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACATTCTCCAGAACCAGACACATGCTTTTCGTGCCAAACCAGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACGATGATGTATTACTGTCAAGGAAAGTCGATTTCTCAAATAGCGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACAAACAGCTGAGGAGTACATGAGAGAAAATGATTCATTCAGTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACTCAGCAAGAAGAATCATTATCCCGAAGAGGGCCCTTTTGGAGGTTTCAGTCTCCTACTTAGCGGAGCCTAAATTGCAACTTACTTTGACTATCCATCAAGATACGCATCTGATGCAAAGTTTCAGTCTCCTACTTAGCGGAGCCTAAATTGCAAC

>CP016379|21|10|737299-738022|CRT
TTTCGGTCTTCTGCTTATCTGAGTTAAGTTGCAACC	ACCAGTGGGGACTGGCGGTGGATCTCGTGGTTAGGAAGCAT
TTTCAGTTTCCTACTTAACGGAGTATAGGTTGCAAC	ACGGCGGGCGGGACTTCGTGTATATGAGCAAAGAGCAGATG
TTTCAGTCTCCTACTTAGTGAAGTCTACATTGCAAC	ACTCAAGGAACTGATACGATAGAATTTAAAGCTACGTTG
TTTCAGTCTCCTACTTAACGGAGTTAAGTTGCAATC	AGAAGAAATTGGATGGGATAAGGAATATAAGCTTTTC
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAAC	ATTCTCCAGAACCAGACACATGCTTTTCGTGCCAAACCAG
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAAC	GATGATGTATTACTGTCAAGGAAAGTCGATTTCTCAAATAGCG
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAAC	AAACAGCTGAGGAGTACATGAGAGAAAATGATTCATTCAG
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAAC	TCAGCAAGAAGAATCATTATCCCGAAGAGGGCCCTTTTGGAGG
TTTCAGTCTCCTACTTAGCGGAGCCTAAATTGCAAC	TTACTTTGACTATCCATCAAGATACGCATCTGATGCAAAG
TTTCAGTCTCCTACTTAGCGGAGCCTAAATTGCAAC

>CP016379|21|15|737376-737560|PILER-CR
TTTCAGTTTCCTACTTAACGGAGTATAGGTTGCA	ACACGGCGGGCGGGACTTCGTGTATATGAGCAAAGAGCAGATG
TTTCAGTCTCCTACTTAGTGAAGTCTACATTGCA	ACACTCAAGGAACTGATACGATAGAATTTAAAGCTACGTTGTTTCAGTCTCCTACTTA
ACGGAGTTAAGTTGCAATCAGAAGAAATTGGATGGGATAAGGAATATAAGCTTTTCTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACAT	TCTCCAGAACCAGACACATGCTTTTCGTGCCAAACCAG
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACGA	TGATGTATTACTGTCAAGGAAAGTCGATTTCTCAAATAGCG


>CP016379|21|16|737601-737792|PILER-CR
	ACACGGCGGGCGGGACTTCGTGTATATGAGCAAAGAGCAGATG
TTTCAGTCTCCTACTTAGTGAAGTCTACATTGCA	ACACTCAAGGAACTGATACGATAGAATTTAAAGCTACGTTGTTTCAGTCTCCTACTTA
ACGGAGTTAAGTTGCAATCAGAAGAAATTGGATGGGATAAGGAATATAAGCTTTTCTTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACAT	TCTCCAGAACCAGACACATGCTTTTCGTGCCAAACCAG
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACGA	TGATGTATTACTGTCAAGGAAAGTCGATTTCTCAAATAGCG
TTTCAGTCTCCTAGCTAACGGAGTCTAGGTTGCAACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72499.1|747075_747399_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	unknown	unknown	gnl|CDD|212669
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	unknown	unknown	gnl|CDD|378935
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.15039e-13
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	3.50923e-70
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.15737e-13
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL
>CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein
MPGVPRKRLREIRQTKYTLEEFAKLVHSSPTHLSDIENGKRDPSPELASAICRILGRSFSELFPDLRENYIKKSALLLSLATQ
>CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein
MRNKRKETMTAQELADLLGIKSVQTVYKLLNEGKIPGVKVGHQWVIPTQAILDWLYVAALGSQKRILEHIGVDFGELMDWIAKLRHYENCSNLDNLVKMPEFGSIKEEVVNLR
>CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein
MSKNIAVDVGFGFVKATDGNKEVIFPSVVGEGREIRYKPGVTINNDAIKNLFAEVDGEKYFVGDLATRQSEFLQSTLSGDRTNSIEYDVLFKTACALLNNGSTEVNIVTGLPVNEFTQYKNTLEKMLLRIHKIKLNDISYSFEIKRAKIIPQPFGTVFNLLLDDQGEIQKREYVNMKIGVIDIGFRTTDFIVVDCLEFVDKLSSSTTVALSSAYKLVGHSLNERFGINKPIYQLDKFIRTGFIPYKGQQMDIRELVGKAFALTTNNIISEVSSLWNIWELDQIIITGGGGVELYAYLKAHIDNCVLVNEGQFSNVKGYLKLANRSFR
>CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein
MVTISIRLRPGKDNDILQWWESLDKGERSGIVRSILRSYINQEDQSQQRVSRLNFGVKKENLEDLGDIEFRMDFPASENEDDNEIDKKVDLLVDQF
>CP016379.1|AZR72499.1|747075_747399_+|hypothetical-protein
MNEFVLGQLDAYCYMVERGKPAAMIPVQKHYTAEAIKFISKCSNSKLKVFVENLSDDWDTLWIYKYPHILEVIKELQQAPDNIFSKWALGKLFGYDEESIQNFINRS

Crispr_ID: CP016379_22

• CRISPR_ID: CP016379_22
• CRISPR_location: 738386-738552
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_22

Consensus_repeat	Method
GGTGTTTCAATTCCTCATAGGTAGGCTACAAACC	PILER-CR
GTTTCAATTCCTCATAGGTAGGCTACAAAC	CRISPRCasFinder

spacers of CP016379_22

>22.1|738420|32|CP016379|PILER-CR
GTGAGTTATAATACCTCTGAAACTGCTCTAAA
>22.2|738486|33|CP016379|PILER-CR
AGGAGGAGAATATCCAGAAGAAATACATGTTGG
>22.3|738419|36|CP016379|CRISPRCasFinder
AGTGAGTTATAATACCTCTGAAACTGCTCTAAAAGT
>22.4|738485|37|CP016379|CRISPRCasFinder
CAGGAGGAGAATATCCAGAAGAAATACATGTTGGGGC

CRISPR arrays and Neighbor proteins around CP016379_22

CRISPR arrays

The CRISPR arrays of CP016379_22

>merge|CP016379|22|738386-738552|PILER-CR,CRISPRCasFinder
GCTGTTTTAATTCCTCATAGGTAGGCTACAAACAGTGAGTTATAATACCTCTGAAACTGCTCTAAAAGTGTTTCAATTCCTCATAGGTAGGCTACAAACCAGGAGGAGAATATCCAGAAGAAATACATGTTGGGGCGTTTCAATTCCTCATAGGTAGGCTACAAACC

>CP016379|22|17|738386-738552|PILER-CR
GCTGTTTTAATTCCTCATAGGTAGGCTACAAACA	GTGAGTTATAATACCTCTGAAACTGCTCTAAA
AGTGTTTCAATTCCTCATAGGTAGGCTACAAACC	AGGAGGAGAATATCCAGAAGAAATACATGTTGG
GGCGTTTCAATTCCTCATAGGTAGGCTACAAACC

>CP016379|22|9|738389-738552|CRISPRCasFinder
GTTTTAATTCCTCATAGGTAGGCTACAAAC	AGTGAGTTATAATACCTCTGAAACTGCTCTAAAAGT
GTTTCAATTCCTCATAGGTAGGCTACAAAC	CAGGAGGAGAATATCCAGAAGAAATACATGTTGGGGC
GTTTCAATTCCTCATAGGTAGGCTACAAACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72499.1|747075_747399_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	unknown	unknown	gnl|CDD|212669
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	unknown	unknown	gnl|CDD|378935
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.15039e-13
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	3.50923e-70
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.15737e-13
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL
>CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein
MPGVPRKRLREIRQTKYTLEEFAKLVHSSPTHLSDIENGKRDPSPELASAICRILGRSFSELFPDLRENYIKKSALLLSLATQ
>CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein
MRNKRKETMTAQELADLLGIKSVQTVYKLLNEGKIPGVKVGHQWVIPTQAILDWLYVAALGSQKRILEHIGVDFGELMDWIAKLRHYENCSNLDNLVKMPEFGSIKEEVVNLR
>CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein
MSKNIAVDVGFGFVKATDGNKEVIFPSVVGEGREIRYKPGVTINNDAIKNLFAEVDGEKYFVGDLATRQSEFLQSTLSGDRTNSIEYDVLFKTACALLNNGSTEVNIVTGLPVNEFTQYKNTLEKMLLRIHKIKLNDISYSFEIKRAKIIPQPFGTVFNLLLDDQGEIQKREYVNMKIGVIDIGFRTTDFIVVDCLEFVDKLSSSTTVALSSAYKLVGHSLNERFGINKPIYQLDKFIRTGFIPYKGQQMDIRELVGKAFALTTNNIISEVSSLWNIWELDQIIITGGGGVELYAYLKAHIDNCVLVNEGQFSNVKGYLKLANRSFR
>CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein
MVTISIRLRPGKDNDILQWWESLDKGERSGIVRSILRSYINQEDQSQQRVSRLNFGVKKENLEDLGDIEFRMDFPASENEDDNEIDKKVDLLVDQF
>CP016379.1|AZR72499.1|747075_747399_+|hypothetical-protein
MNEFVLGQLDAYCYMVERGKPAAMIPVQKHYTAEAIKFISKCSNSKLKVFVENLSDDWDTLWIYKYPHILEVIKELQQAPDNIFSKWALGKLFGYDEESIQNFINRS

Crispr_ID: CP016379_23

• CRISPR_ID: CP016379_23
• CRISPR_location: 739264-739834
• CRISPR_type: TypeV-U3
• Repeat_type: NA
• Spacer_info: 8 spacers
• Cas_protein_info: c2c10_CAS-V-U3

Consensus repeat of CP016379_23

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAGGCTACAAAC	CRISPRCasFinder
GTTTCAATTCCTNATAGGTAGGCTACAAAC	CRT
GTTTCAATTCCTCATAGGTAGGCTACAAAC	PILER-CR

spacers of CP016379_23

>23.1|739294|37|CP016379|CRISPRCasFinder,CRT
GTTTCGAACGACATTTACACTGACGGTTTTGGAAGCA
>23.2|739361|40|CP016379|CRISPRCasFinder,CRT,PILER-CR
CCACAGCCGCCGATTCGCTCATCATGTGTCTCTTCGTAGG
>23.3|739431|34|CP016379|CRISPRCasFinder,CRT,PILER-CR
GCAATTACATTTGTGCTCATTTTGATATAGAAGG
>23.4|739495|38|CP016379|CRISPRCasFinder,CRT,PILER-CR
GCAATAAGTGTACTAAAGGCACTAGAAAGACTTGAAAG
>23.5|739563|37|CP016379|CRISPRCasFinder,CRT,PILER-CR
AAAATGAAAGTAGAACAGAATCAAGAAAGAGATTTAT
>23.6|739630|35|CP016379|CRISPRCasFinder,CRT,PILER-CR
TCTTTTACTTCGTCCAAAGTTTCTTCTGCTTTCTC
>23.7|739695|40|CP016379|CRISPRCasFinder,CRT,PILER-CR
CAGGAATTGATTACAGTCGAATAACAGCACATTCAAACTT
>23.8|739765|40|CP016379|CRISPRCasFinder,CRT,PILER-CR
TGGAGCAAATCACAGTTTTAAAACAAAAACTTGCGGATTA

CRISPR arrays and Neighbor proteins around CP016379_23

CRISPR arrays

The CRISPR arrays of CP016379_23

>merge|CP016379|23|739264-739834|CRISPRCasFinder,CRT,PILER-CR
GGTTTTAATCCTGATAGGTAGGCTACAAACGTTTCGAACGACATTTACACTGACGGTTTTGGAAGCAGTTTCAATTCCTCATAGGTAGGCTACAAACCCACAGCCGCCGATTCGCTCATCATGTGTCTCTTCGTAGGGTTTCAATTCCTCATAGGTAGGCTACAAACGCAATTACATTTGTGCTCATTTTGATATAGAAGGGTTTCAATTCCTCATAGGTAGGCTACAAACGCAATAAGTGTACTAAAGGCACTAGAAAGACTTGAAAGGTTTCAATTCCTCATAGGTAGGCTACAAACAAAATGAAAGTAGAACAGAATCAAGAAAGAGATTTATGTTTCAATTCCTCATAGGTAGGCTACAAACTCTTTTACTTCGTCCAAAGTTTCTTCTGCTTTCTCGTTTCAATTCCTTATAGGTAGGCTACAAACCAGGAATTGATTACAGTCGAATAACAGCACATTCAAACTTGTTTCAATTCCTTATAGGTAGGCTACAAACTGGAGCAAATCACAGTTTTAAAACAAAAACTTGCGGATTAGTTTCAATTCCTTATAGGTAGGCTACAAAC

>CP016379|23|10|739264-739834|CRISPRCasFinder
GGTTTTAATCCTGATAGGTAGGCTACAAAC	GTTTCGAACGACATTTACACTGACGGTTTTGGAAGCA
GTTTCAATTCCTCATAGGTAGGCTACAAAC	CCACAGCCGCCGATTCGCTCATCATGTGTCTCTTCGTAGG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GCAATTACATTTGTGCTCATTTTGATATAGAAGG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GCAATAAGTGTACTAAAGGCACTAGAAAGACTTGAAAG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	AAAATGAAAGTAGAACAGAATCAAGAAAGAGATTTAT
GTTTCAATTCCTCATAGGTAGGCTACAAAC	TCTTTTACTTCGTCCAAAGTTTCTTCTGCTTTCTC
GTTTCAATTCCTTATAGGTAGGCTACAAAC	CAGGAATTGATTACAGTCGAATAACAGCACATTCAAACTT
GTTTCAATTCCTTATAGGTAGGCTACAAAC	TGGAGCAAATCACAGTTTTAAAACAAAAACTTGCGGATTA
GTTTCAATTCCTTATAGGTAGGCTACAAAC

>CP016379|23|11|739264-739834|CRT
GGTTTTAATCCTGATAGGTAGGCTACAAAC	GTTTCGAACGACATTTACACTGACGGTTTTGGAAGCA
GTTTCAATTCCTCATAGGTAGGCTACAAAC	CCACAGCCGCCGATTCGCTCATCATGTGTCTCTTCGTAGG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GCAATTACATTTGTGCTCATTTTGATATAGAAGG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GCAATAAGTGTACTAAAGGCACTAGAAAGACTTGAAAG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	AAAATGAAAGTAGAACAGAATCAAGAAAGAGATTTAT
GTTTCAATTCCTCATAGGTAGGCTACAAAC	TCTTTTACTTCGTCCAAAGTTTCTTCTGCTTTCTC
GTTTCAATTCCTTATAGGTAGGCTACAAAC	CAGGAATTGATTACAGTCGAATAACAGCACATTCAAACTT
GTTTCAATTCCTTATAGGTAGGCTACAAAC	TGGAGCAAATCACAGTTTTAAAACAAAAACTTGCGGATTA
GTTTCAATTCCTTATAGGTAGGCTACAAAC

>CP016379|23|18|739331-739834|PILER-CR
GTTTCAATTCCTCATAGGTAGGCTACAAAC	CCACAGCCGCCGATTCGCTCATCATGTGTCTCTTCGTAGG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GCAATTACATTTGTGCTCATTTTGATATAGAAGG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	GCAATAAGTGTACTAAAGGCACTAGAAAGACTTGAAAG
GTTTCAATTCCTCATAGGTAGGCTACAAAC	AAAATGAAAGTAGAACAGAATCAAGAAAGAGATTTAT
GTTTCAATTCCTCATAGGTAGGCTACAAAC	TCTTTTACTTCGTCCAAAGTTTCTTCTGCTTTCTC
GTTTCAATTCCTTATAGGTAGGCTACAAAC	CAGGAATTGATTACAGTCGAATAACAGCACATTCAAACTT
GTTTCAATTCCTTATAGGTAGGCTACAAAC	TGGAGCAAATCACAGTTTTAAAACAAAAACTTGCGGATTA
GTTTCAATTCCTTATAGGTAGGCTACAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72499.1|747075_747399_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	gnl|CDD|223747
CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	unknown	unknown	gnl|CDD|376616
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	unknown	unknown	gnl|CDD|212669
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	unknown	unknown	gnl|CDD|379262
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	unknown	unknown	gnl|CDD|224522
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	unknown	unknown	gnl|CDD|197775
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	unknown	unknown	gnl|CDD|378935
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	unknown	unknown	gnl|CDD|238045

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	c2c10_CAS-V-U3	-	6.1e-34	112.3	18.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein	gnl|CDD|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	0.00738683
CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00652661
CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.94055e-05
CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.96679e-23
CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.15039e-13
CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.47344e-10
CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	4.20775e-27
CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000162385
CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	3.50923e-70
CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.06126e-05
CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.06728e-15
CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.15737e-13
CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.18234e-11

Protein sequences

>CP016379.1|AZR72489.1|736152_736539_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEEIEANQVKMHSRTEKIEAKIEKLEVNQNVMQSKLEELKTSQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72488.1|733177_734263_+|hypothetical-protein
MHITLHHIKLYKPSRNKQEQLNLLLRNWNKGLRSALKIIKHWGFTSYTKSHKHTYRVLRNNYSLPSQIAVECNRKAIEIFKVNQISRFKSNVPVRLVNGKSFAIIVKNGRYFAKILTPNGKIFCPLAFGKYQLNYLADERYIIKTADLYFSKGEWYLNLVLEYQQKQIEPKTVMGIDLGIVNLASVAVIDQDKNILHTEMFSGRELRFKRLRYRQKRKLKSKKAGSQKISTIKENRICREVNFHIANRIIELAAKNNSLIVFENLKNIRSNITKEKDRLSNYEKNSWAYYQLKEFVKHKACLHGIPVIEISPFKTSQICSTCQAEGQRITQSLFLCPNGHRHNADKNASINIAVRGLQHVG
>CP016379.1|AZR72487.1|732901_733120_+|hypothetical-protein
MYQTAYHIVWIPKYRRKILVGDVREFTIKTLHQIAEDKGFEILALEVCPDHIHLFVSIPPAVSISQAVKCFS
>CP016379.1|AZR72486.1|731975_732791_+|hypothetical-protein
MNKNVDYLQDYYSFLGCAKEIFEAKKIENAIDELLKNAMSLHNMIFNVDEEEKKNIHQGYLSDLETVLPYVELTYELTYDELYKNKAIKPASSRNSFHILYQPKRKVRYIIMNFFSGFPLVQLGEIKHAWNNFIEFRTAKLFFAFLGTILTFLVGTFSIHHWTLFIMTIIHLLTRLMANRYRNQDDYVHCYRSIQLFAWPYMLLVLGNFLNYSITITGFPEDTFFIFWVWWLIWSELKGIVENAKVANLPIPPMLEEIINKSKDKNIGMPL
>CP016379.1|AZR72485.1|731338_731992_+|hypothetical-protein
MKQKFLPLFIKVDFRLDIIKLRELDENIFTKIKNKYGFNTLEINKDEVILRGGFPMFSCIFSEESIQIVTFTSDIQTAIDSIIDLVNQINILAEIEIQYISYIEIANLLKFQDNKDLFGFFVNCKDYSDGVEISGAYLTLDTIDGKKNIKYIFKFEDEKGFSAIALKALLNFKDDIELKGLLEHNIKYLQEKMTYFLSTRSGKFLLGVGVNKIEQKR
>CP016379.1|AZR72484.1|727122_727350_+|hypothetical-protein
MWRTHPISKLFRERFQFLIGRLETFVALRDGQITQFEFQFLIGRLETRLLAMPKEVFFKKFQFLIGRLQTKRNRI
>CP016379.1|AZR72483.1|725429_725732_-|hypothetical-protein
MDNIEKILHQILENQVKMQSKIEKIEAKLEELKTNQERIEKKVDVISNQVADLTEFKVTTTEKLDKLTDKVNKISKTITFIKHKELQNEEDIFYLKENLS
>CP016379.1|AZR72482.1|719842_720256_-|hypothetical-protein
MAENLISWPDYFPKGCPPDTARRDEVVVYRGIRNNNKVTAEDFIPLKILQPRRKFKGEDNCNACGISVFKDIKDLIKKRKSLPALKKKYPYIAIGTIKRNHGLILETYGGSHITWWVKPGVEPHTFFEVYMEDESNE
>CP016379.1|AZR72481.1|718656_719850_-|hypothetical-protein
MNENYICLDFIGKLKILEIYEYYDGPRLFSCESISGQKYLAVWIDFDEDSERWLYVPVSNHRLSSVKRGLISLYEAFNCPEDGWLWDVKTFFHDQSNIVTQITPNQLSKEDLPDEDAFLNIQDKTLPDLSEDPCVFATRTRRDVIDLSLTGDSVHLNEIDTGVLGAILLNLQTLIHSLAYKSGGIRGRIPKNIKEATILKTVAVFEGSFGVRLVSKHSANLFNKTPVSEPLEKLMNLLSAKGDREKLSSLMKSLSLKSKIKFRQLLKALKDGNTEIKTIWGSPDLKSNAVSLTIEDINKALEVFELDEKEMTEINSYQGKLVGINMNKYSFEFITVDEERIVGELSEDLYKNVFEVPMFAEVKIKEIYEFNYVTQEEKITSILLEVNEISNPNIKDS
>CP016379.1|AZR72480.1|716625_716865_+|hypothetical-protein
MKFATKNKRNILVVIIAIVILVFIVFSFLAKKFTLKIEFERDANKTKFNLEISSVIMYLVGISMMKYKKKESKIRKEKN
>CP016379.1|AZR72490.1|740292_740784_-|hypothetical-protein
MLGQQILNFRLKKGLSQDELGELMGYTGSYISQIENQKKTPSMKFLQKFSEVSKIPIEELLNSSSQHLGLKFKQLRIEKGLKVGDISEQTGIDFFRIADFEDGIVALTWEEMQRIADILGVDSTEIESTYDEIIRIIRHNLEQLPISSEKVELILEYIERQIK
>CP016379.1|AZR72491.1|740790_741375_-|hypothetical-protein
MFRSDAHKILRKLRKERGWSQEEVGKALGRSAGWVSNKERSTRGISAEDLGMFADLYEVDPAVFFVSPYSASEIGKTISEALQKYNLSEAQLADELDMDYFRLANALLGEVELTPAELQTIGNYLNITEPPFLHSAEHIIQKILDLATKLGLQAKKINMLRNFLENEVKKLNDNQKSYNPHSTKTRIETKYTQR
>CP016379.1|AZR72492.1|741465_741996_-|hypothetical-protein
MRFLTHQLGTKLREERKRRNLSQAEVGEGIGTSSSYISQLENGERKPSLENYLALISFFGVDFTYFLNTEDNDKEIVGREIKALREKRGWSIGELRDRSGVDFFRIGRAENGEIELSKEELERIADAFGIDINYFFCRYEFNVSRIINSCKSLGLTDNQIHLVVEFINDCLKTNKL
>CP016379.1|AZR72493.1|742382_743372_+|hypothetical-protein
MSYEEAKSHFDSENYEKAIELFSAMQVECEMRGDKEGAEIARRELGRSYFRLEKYGEAEEHFSQLFKNTRNDKIKDYCLTMIATIKATKDDYTNALKILDKITPTPINLINKVFILYYLKKYDGIDEAAHRALTIIDQLKEFDLSNDLLSKFKQAAGLIYSIMGKRDKGLIYLKESLKYTNNNVEKSRIYNDIAEIYIEMDNFEEAEKALLNAKKLMKSSSNKFTKATNLKLFGILNKKRKNFEIASKYLSEALVLMQEYDAVKHLAEIKFYLADVKFSKIKTNKMYEIYQGAEIYAEGVSNEKRLEGVNIKNAQIVDSIDGSTDFGGS
>CP016379.1|AZR72494.1|743556_744096_-|hypothetical-protein
MILDNRKIAATIQSIQNRLGLTNEEFGKTLKSPEKPDGVSGSYISHIKNGKREMSKKLFQVFCEQYDLNPHEFMKEENKQEVDIAETINQLMRIRGLDIEEISRMTGIDILDLSQLKRGKLRPSEEHIRKLSIALGVKPEVISQGRVFKSFEIIRRELESLYLDPEFIDHVMKAIEREL
>CP016379.1|AZR72495.1|744817_745069_+|hypothetical-protein
MPGVPRKRLREIRQTKYTLEEFAKLVHSSPTHLSDIENGKRDPSPELASAICRILGRSFSELFPDLRENYIKKSALLLSLATQ
>CP016379.1|AZR72496.1|745117_745459_+|hypothetical-protein
MRNKRKETMTAQELADLLGIKSVQTVYKLLNEGKIPGVKVGHQWVIPTQAILDWLYVAALGSQKRILEHIGVDFGELMDWIAKLRHYENCSNLDNLVKMPEFGSIKEEVVNLR
>CP016379.1|AZR72497.1|745572_746556_+|hypothetical-protein
MSKNIAVDVGFGFVKATDGNKEVIFPSVVGEGREIRYKPGVTINNDAIKNLFAEVDGEKYFVGDLATRQSEFLQSTLSGDRTNSIEYDVLFKTACALLNNGSTEVNIVTGLPVNEFTQYKNTLEKMLLRIHKIKLNDISYSFEIKRAKIIPQPFGTVFNLLLDDQGEIQKREYVNMKIGVIDIGFRTTDFIVVDCLEFVDKLSSSTTVALSSAYKLVGHSLNERFGINKPIYQLDKFIRTGFIPYKGQQMDIRELVGKAFALTTNNIISEVSSLWNIWELDQIIITGGGGVELYAYLKAHIDNCVLVNEGQFSNVKGYLKLANRSFR
>CP016379.1|AZR72498.1|746561_746852_+|hypothetical-protein
MVTISIRLRPGKDNDILQWWESLDKGERSGIVRSILRSYINQEDQSQQRVSRLNFGVKKENLEDLGDIEFRMDFPASENEDDNEIDKKVDLLVDQF
>CP016379.1|AZR72499.1|747075_747399_+|hypothetical-protein
MNEFVLGQLDAYCYMVERGKPAAMIPVQKHYTAEAIKFISKCSNSKLKVFVENLSDDWDTLWIYKYPHILEVIKELQQAPDNIFSKWALGKLFGYDEESIQNFINRS

Crispr_ID: CP016379_25

• CRISPR_ID: CP016379_25
• CRISPR_location: 790515-790790
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of CP016379_25

Consensus_repeat	Method
TTTCAGTCTCCTAGCTAACGGAGTCTAGATTGCAAC	PILER-CR
GTTGCAACCTAGACTCCGTTAGCTAGGAGACTGAAA	CRISPRCasFinder
CTAGACTCCGTTAGCTAGGAGACTGAAA	CRT

spacers of CP016379_25

>25.1|790551|42|CP016379|PILER-CR,CRISPRCasFinder
CCGAGGCTTGTCATCTATTCTAAGATATGCTTTCATTTTTGT
>25.2|790629|40|CP016379|PILER-CR,CRISPRCasFinder
GTTCGCAGCATAATGACCCAACTTCATAAGAAAAACCTCC
>25.3|790705|50|CP016379|CRISPRCasFinder
CCCTGCAAATTCAAATTGCGGATGATTACTTAATAAATTCCAATTCTTAA
>25.4|790551|50|CP016379|CRT
CCGAGGCTTGTCATCTATTCTAAGATATGCTTTCATTTTTGTGTTGCAAT
>25.5|790629|48|CP016379|CRT
GTTCGCAGCATAATGACCCAACTTCATAAGAAAAACCTCCGTTGCAAT
>25.6|790705|58|CP016379|CRT
CCCTGCAAATTCAAATTGCGGATGATTACTTAATAAATTCCAATTCTTAAGTTGCAAC

CRISPR arrays and Neighbor proteins around CP016379_25

CRISPR arrays

The CRISPR arrays of CP016379_25

>merge|CP016379|25|790515-790790|PILER-CR,CRISPRCasFinder,CRT
GTTGCAACCTAGACTCCGTTAGCTAGGAGACTGAAACCGAGGCTTGTCATCTATTCTAAGATATGCTTTCATTTTTGTGTTGCAATCTAGACTCCGTTAGCTAGGAGACTGAAAGTTCGCAGCATAATGACCCAACTTCATAAGAAAAACCTCCGTTGCAATCTAGACTCCGTTAGCTAGGAGACTGAAACCCTGCAAATTCAAATTGCGGATGATTACTTAATAAATTCCAATTCTTAAGTTGCAACCTAGACTCCGTTAGCTAGGAGACTTCAA

>CP016379|25|19|790515-790704|PILER-CR
GTTGCAACCTAGACTCCGTTAGCTAGGAGACTGAAA	CCGAGGCTTGTCATCTATTCTAAGATATGCTTTCATTTTTGT
GTTGCAATCTAGACTCCGTTAGCTAGGAGACTGAAA	GTTCGCAGCATAATGACCCAACTTCATAAGAAAAACCTCC
GTTGCAATCTAGACTCCGTTAGCTAGGAGACTGAAA

>CP016379|25|12|790515-790790|CRISPRCasFinder
GTTGCAACCTAGACTCCGTTAGCTAGGAGACTGAAA	CCGAGGCTTGTCATCTATTCTAAGATATGCTTTCATTTTTGT
GTTGCAATCTAGACTCCGTTAGCTAGGAGACTGAAA	GTTCGCAGCATAATGACCCAACTTCATAAGAAAAACCTCC
GTTGCAATCTAGACTCCGTTAGCTAGGAGACTGAAA	CCCTGCAAATTCAAATTGCGGATGATTACTTAATAAATTCCAATTCTTAA
GTTGCAACCTAGACTCCGTTAGCTAGGAGACTTCAA

>CP016379|25|12|790523-790790|CRT
CTAGACTCCGTTAGCTAGGAGACTGAAA	CCGAGGCTTGTCATCTATTCTAAGATATGCTTTCATTTTTGTGTTGCAAT
CTAGACTCCGTTAGCTAGGAGACTGAAA	GTTCGCAGCATAATGACCCAACTTCATAAGAAAAACCTCCGTTGCAAT
CTAGACTCCGTTAGCTAGGAGACTGAAA	CCCTGCAAATTCAAATTGCGGATGATTACTTAATAAATTCCAATTCTTAAGTTGCAAC
CTAGACTCCGTTAGCTAGGAGACTTCAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP016379.1|AZR72539.1|785634_787020_+|hypothetical-protein	unknown	unknown	gnl|CDD|223714
CP016379.1|AZR72535.1|774271_778801_+|phage-tail-tape-measure-protein	unknown	unknown	gnl|CDD|378413
CP016379.1|AZR72545.1|791403_792375_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP016379.1|AZR72542.1|788426_788978_+|hypothetical-protein	unknown	unknown	gnl|CDD|119407
CP016379.1|AZR72554.1|805113_805566_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72551.1|802490_803819_+|ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl|CDD|223694
CP016379.1|AZR72552.1|803815_804373_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl|CDD|273139
CP016379.1|AZR72538.1|784426_785584_+|hypothetical-protein	unknown	unknown	gnl|CDD|237863
CP016379.1|AZR72548.1|796792_798649_+|hypothetical-protein	unknown	unknown	gnl|CDD|143479
CP016379.1|AZR72541.1|787984_788416_+|hypothetical-protein	unknown	unknown	gnl|CDD|377457
CP016379.1|AZR72547.1|795593_795947_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72540.1|787019_787874_+|hypothetical-protein	unknown	unknown	gnl|CDD|367955
CP016379.1|AZR72544.1|789941_790151_+|hypothetical-protein	unknown	unknown	gnl|CDD|378935
CP016379.1|AZR72543.1|789007_789439_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72546.1|793006_793216_+|hypothetical-protein	unknown	unknown	gnl|CDD|378935
CP016379.1|AZR72537.1|779061_784422_+|hypothetical-protein	unknown	unknown	gnl|CDD|379155
CP016379.1|AZR72553.1|804369_804819_+|hypothetical-protein	unknown	unknown	gnl|CDD|368021
CP016379.1|AZR72549.1|798819_799200_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72550.1|800785_801004_+|hypothetical-protein	unknown	unknown	unknown
CP016379.1|AZR72536.1|778815_779040_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP016379.1|AZR72539.1|785634_787020_+|hypothetical-protein	gnl|CDD|223714	COG0641, AslB, Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only].	3.65865e-29
CP016379.1|AZR72546.1|793006_793216_+|hypothetical-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	3.67262e-08
CP016379.1|AZR72545.1|791403_792375_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.46188e-07
CP016379.1|AZR72542.1|788426_788978_+|hypothetical-protein	gnl|CDD|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	4.16517e-63
CP016379.1|AZR72552.1|803815_804373_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl|CDD|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	8.95555e-44
CP016379.1|AZR72538.1|784426_785584_+|hypothetical-protein	gnl|CDD|237863	PRK14949, PRK14949, DNA polymerase III subunits gamma and tau; Provisional.	0.00866775
CP016379.1|AZR72548.1|796792_798649_+|hypothetical-protein	gnl|CDD|143479	cd07563, Peptidase_S41_IRBP, Interphotoreceptor retinoid-binding protein; serine protease family S41. Interphotoreceptor retinoid-binding protein (IRBP) is a homolog of the S41 protease, C-terminal processing peptidase (CTPase) family. It is thought to facilitate the compartmentalization of the visual cycle that requires poorly soluble and potentially toxic retinoids to cross the aqueous subretinal space between the photoreceptors and the retinal pigment epithelium (RPE). IRBP is secreted by photoreceptors into the interphotoreceptor matrix (IPM) where it is rapidly turned over by a combination of RPE and photoreceptor endocytosis. It is the most abundant soluble protein component of the IPM, consisting of homologous modules, each repeat structure arising through the duplication (as in teleost IRBP) or quadruplication (in tetrapods) of an ancient gene, arisen in the early evolution of the vertebrate eye. IRBP has been shown to promote the release of all-trans retinol from photoreceptors and facilitates its delivery to the RPE. Conversely, IRBP can promote the release of 11-cis-retinal from the RPE, prevent its isomerization in the subretinal space, and transfer it to photoreceptors. In vivo evidence implicates IRBP as a retinoid transporter in the visual cycle, suggesting a critical role for IRBP in cone function essential for human vision. IRBP is a dominant autoimmune antigen in the eye; IRBP proteolysis analysis has proven a useful biomarker for autoimmune uveitis (AU) disorders, a major cause of blindness. This family also includes a chlamydia-secreted protein, designated chlamydia protease-like activity factor (CPAF), known to degrade host proteins, enabling Chlamydia to evade host defenses and replicate.	9.81133e-27
CP016379.1|AZR72541.1|787984_788416_+|hypothetical-protein	gnl|CDD|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	2.74332e-19
CP016379.1|AZR72535.1|774271_778801_+|phage-tail-tape-measure-protein	gnl|CDD|378413	pfam10145, PhageMin_Tail, Phage-related minor tail protein. Members of this family are found in putative phage tail tape measure proteins.	2.56591e-27
CP016379.1|AZR72540.1|787019_787874_+|hypothetical-protein	gnl|CDD|367955	pfam04467, DUF483, Protein of unknown function (DUF483). Family of uncharacterized prokaryotic proteins.	1.89864e-06
CP016379.1|AZR72544.1|789941_790151_+|hypothetical-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	3.68549e-08
CP016379.1|AZR72537.1|779061_784422_+|hypothetical-protein	gnl|CDD|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	1.64544e-12
CP016379.1|AZR72551.1|802490_803819_+|ribosomal-protein-S12-methylthiotransferase-RimO	gnl|CDD|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	0
CP016379.1|AZR72553.1|804369_804819_+|hypothetical-protein	gnl|CDD|368021	pfam04608, PgpA, Phosphatidylglycerophosphatase A. This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.	1.48632e-38

Protein sequences

>CP016379.1|AZR72544.1|789941_790151_+|hypothetical-protein
MFANDQEYEQFLKENVLSTKDAADFLGITRKGISYLVKEGKLRPFKDQDRVRLFSRREVERYKKERDGV
>CP016379.1|AZR72543.1|789007_789439_+|hypothetical-protein
MVNEFVGTFFDWLWGISPGVVLVFLAVAICVAIWGKRLVFLLFKNTIGRKYALQAVRAAEKMVILLGKEKWMLALEYLNVKLKRKFGISVPKYVLEKWVDWAYKKMLQNGEEIKASVVLGVPKDQFRLFKEGDSFRIKYSKEF
>CP016379.1|AZR72542.1|788426_788978_+|hypothetical-protein
MKRIICIDPGHGEPWPGAVFGDIKESEFCLDVGNFLSRELQRRGHIVVQTRYTSSAIVPGRLTEDLTRRAEIANQIEADIFLSLHFNSHPNHEANGVETWYFKHSTKGRYLAELIQNQLIKKFKMRNRGIKGSRGLIVLKKTLMPAVLIELGFITNPRDRNIMTASVYPERVACAIADGVEIF
>CP016379.1|AZR72541.1|787984_788416_+|hypothetical-protein
MSIQEIMDSIKKVLEAPLFKGVFSFVGLVLTKLFGKPDTALQAFIMLLILDLITGFIKAFLSGSARSFISHEKGRKKYLGYAVVLSVCHLLDMAAVPGLRNVALFWGSATETYSILENMEEMGVPMPEFIKQQLNNTKKKYKL
>CP016379.1|AZR72540.1|787019_787874_+|hypothetical-protein
MIKMDAKKDFVVGLDVPPTAEIIWNDPDAEEEWGSIVERAKTLHYRLEYEMVKHKKRKCATLHISPRNYDKDIERILSDGLVWLPIQRTKSYTGFSHKHFPVDELDMNSNVYGVLARNLEDAEDFRAHSMQKKVNHKGIGKLLGFPKCCSGFFVEEWSNGFYDPVYQSALKSKNVKEIGERHIKIRPHIATHQMMRYVGFRLTSHFPCSLDCKDSIEIGKVWYDLAKKIDPQGLRALERILTLPGRWEVLHGVAVVVTEPFTIIANSIPTKEKWVVEWDEVDTY
>CP016379.1|AZR72539.1|785634_787020_+|hypothetical-protein
MSLSIKVTNTVCQAGCEYCYEIPLRENGRGVRPFDLDAIMNEMEYEWKKTSLGQSGQIYLHGGEALTAGHEVVEKLLRKAYELSGSSSIQTYGYLIDDRYIKIFKKYKTSVGISIDGPYPLNELRKVPGQNTEEITKKVHENIKKLKDNGISVGMIVVLHKKNAVGDRLNRLKEWIIELRDKYGVDGGRLNMMVGIHPQAKKYELTPEEAKIAWTELAKLVLVEEDELHWQPFHDIVSNLLGLEQGTCTFNACQYYHAHTEPVIFSDGKTGTCLKTCGKDGHVYPRYLDYKWYDDSQKRFGLIRYDILPKIPQEDGGCKGCKYWRNCLGGCPSAGIDNDWRNKTRFCEALKGLFELVEKHLKRLMPNIVLSTDKEVTFLSKYGITGMQPKAFVYMDYDTAKRPSSWRREAKESKKENHMQIRVPIKGLNGDGCKQFTSPIEHLDGHIRHLDSNYHDLKGEL
>CP016379.1|AZR72538.1|784426_785584_+|hypothetical-protein
MNSQQGKIWIDGSYLCIWRYGEANYYKILGEIAGNDPNTPPGTLYLEVGRIVYHDTSYNKRIIRVKQNTSYPTSRQDGSLAIDPVNYLWFAWQGYKYEVTHEDASHSDMNLHDDIAARSSSYHSDISYSDHDDHEDSAHNDWNDYTDEYINWSDYTDDPPHQDWSDWNDYNNWSDYIDDYGNWADNVLHQDWNDYTDEYINYSDHNDTVHSDWSDYNDVTHSDWSNHNDLYWSDFGFDDHTDWSDYNNTAHTDWSDYNDTHSDWSNHSDGYASPVWSDHNDVPHSDSHTDQWYSPAWSDHNDVTGVNWSDHTDVHEDDWSNHTDSYAYPPYNDHYDTAHTDYSDHSDRDHSNHSDYSDSPHYDYTDHLNASHADNPIPAPYTDNS
>CP016379.1|AZR72537.1|779061_784422_+|hypothetical-protein
MGQRLTIIEDFQQGTLNNVINSAGTLKLVQLTNAFPHSQSFEDCAGEHIGDINNSNAVKTDIGGGWQVATHYNTTTIRVETDGGYHGTKRLAFIHDGSSGWKGAVSGALSVIAGKWYRVSVRARANMKSSQVFSEGYAFYVYGVYSVKFSWNVKPTDNPGKWVTGVAIFQAPDNYTGYMYLYGLTDGENGLILEYDAVMWEEFDADPTNQPFGFTVNTGYPIEGGERISPVVDISAVGIAQKSRCKQTAAIPTDTNIELYSSLDDGKTWQGVVPGWNPLASRIGLKFDGVDDYVYIPSQSYLALTGDEPETVEMRVKPNDKASNYFLFQANTWSRRMAWSGYKFYVLVTDIDGTLHQLVTPNNYAPNNVYHITYTFDENYVLSVYVNGELAVQKTIGKPLKPADSYWWFGSARAGSDTCYFDGTIYEARFWRGIARTQAEIQADMDKHLTGDETGLIGYWTFNTGEGSTVKDRVYRGNYYRADGTIYGAQWDVEKISGYVVGQQLLLKQKLLTDDPSNTPQLQSLETIITPANALVVTDSFKSNCKDFSLRNEHNIDVYNVTKAAYITQYIDLTSLDIRCEETGIFGHSSANTLTFDIELSPTDDISTIIQEGDVIRVEETFNNEQITIFVGYADNPPVEYNNLKHRFRIEAYDYIKRGIQYIFQDHEVKTNWYLCNNDAPDQSLAHYLGTLMGFSYNDMLFEDITDANGNYITIPYAHLERGKNVLAEFSTLVQSVCGKLFVNHDGVLVLTSPFNEEDFYDINVTFDDNILGKIEVKSIPATNDEVRVIYDTFHIAERQVCWMLYDKTSYDEINDKANMLLPAGETSAWIKIQLVTPICLNLEGAAPEIVVEDANGNDMSAYFQYDLELDMTGGKVRFYNLHSTEDLYIQKFKIYGQPLEKLSGNEYIYSEATTPNNPLEIKNKFIQTDSLAEAVAKYTYHMTCKDRKLYKFKTCYAPYLALTNKVKIQKRDINTEAVVTRYTHAVQDNYLVTKVELLEFIPYEGFPGNLTAIQTAPNIKDDKTEFTFSKMENDGIFPEGLPVPQPTGVVGIGSFKHIFIEWNPVDRRDLLGYNIYVDDGNSYKQYFTKATFCSIEAESGVTYNVQVTAVTLAGESTKTTAIQVTTASGVDWSEVVNAAVNTNDIVDRAISTVKIALDAITSDEIANSVVQTAHLINQAVTATKIALLAVQTSHIENLAVDTAKINDLAVTTGKLVDLAVQSAKINDLAVISTKIADLAVATAKIADLAVTNAKIASLAVAETNIQDGSITNAKIANAAVDNAKIANAAVDSAKIANASITSAHIQNLAVQDAHIQDLNGSKIHAKSITAEQIRAGEFLPIAKPEGAHLWHFDRSLISTDGIRPEGTPIATLRLNEGKFGGAVAVEEGTENLLATVGGGAAQDWSKWSHWNSSYWGKTEQYDDEKWGKVFKGTKDGASSSSTYIYDYYPYSYAVGDVLTFSCYMRVNKDITKTIDFYVNSSAGGQHHVATPDSKVITFKAGEWQYITWTSGPVTETVNGTGGFGLAMGSGWEGYVVEIAYPQLEKKPFATSFVNGTRASGDLAYSADIIDVNKTTWHFVWIPEQSLDSMVDQASYPKILSVGEYYKNNSFVLWFYDKYIALYIKGSTAYHWSAAPSWIPPAGWYQPYNKYTFDVQIENGNHFKVYLDGELIIETTITDSFTGVAGNKWWVGDNTTSSAANALFDELMVSNEIHTAEEIKAWCESQAPFFDNESVVSGGSTIIDANGFRAYDGNGLLMIELNSQKGTGFFKGSIEAEEFILPIRSV
>CP016379.1|AZR72536.1|778815_779040_+|hypothetical-protein
MLYKFLVHLTSGEQKEVIAENFMPANGSKVYFKIGQRYIAMYKEEQIDKIDFLGEYIPETTTETTTETTVDPQV
>CP016379.1|AZR72535.1|774271_778801_+|phage-tail-tape-measure-protein
MNDAAVLEMIIRARQQLHGIDATIQMIKKMKKQFRELARTVTTYAKQIKEAVEKVKESFIRLNNAMHMLRNTALKAFTAIVAFTGIPSKMYMDFQQGMSNVNTLLNVSREELDRYSQGVIEVSNKIGESAKELTGALYDIISAGVEASHSIEVLELSGKAAKAGMTQTKVAVNAGIAAINAYNLEISELSRVYDLQFSTVKKGVITFAQLASAQGQLIPSARKVNATLEEMYGSLAYLTKQGLSAEEASTSLARAFDALVEQKSSFAQLGINVFDEMTGQFRGLETIVTELADKLQGLTEEEQANLLENLGLDIRAQRAIIPMIKNIEQYKETVADVANSAGAMEEAYKRAIDNIAFHWNRAKQNVINAVMNIGMTFEDEIRDMLDQITAWARAIAGFVKDNKEVIKSVIESAIKLAGTVALFTMVAAAIMTLMTPIGMVTAGIGILAAAWYLNIGGIREKTENAVNFITQKWNELKLWWQDTTWTEKAKDIGKLVLNFGGFIWSESIDLLKKFDAWIGKQLDMDDNGRIDLGDLILLVKIIWESVNDIWNAFSDWMKDQGLVGGDLWEAIKNIWNSNIGNVLKIGFLVKWSAIKIPSLISYLITHVEGLSLLGSGVGLALSLGQIALVGAIIWSILPEDWKEEIRKNVINPVVEFVKKGWSELANFELDPHQLFVDFVEKVKEWVNNTLTLENFKKWGKLIGEAILEGIKSMINPANWFSNNYTKPAVMQSSYWSNYANPENWNIQSNADGGLIIGPGTGTSDSILSWVSNGEYIVNARATRKWLPLLEAINEDRLPKFASGGYINLSTGAGTGGGASFAEANIAILEILGLTGNTAAESTLRYLAQISHDTENFQVIAQIIAGLYKTVEDYRKELENIREETEKLINEYNNGDNGGNNGPPEAESNYWKEFVNVMSNILESTLDDFASIFEDTTRTFIIGITNTIHSLNAHEEGVWGAVSEITNLFKGGNFEEKLAGLSLETTSAMVSFFETIRDTIISYAEQNAEKQYEEFKEAVDQFQEVVEQLTDAIRQGGSLQKARELYQNTKLEAEQVAREYAQYQEAQRQAQGAKQGAGWGALLGGIAGFLIGGPIGATIGAAIGGAAGAGVGYLANEGINYEEELQKLTEELEKAKETLAKTIEESFGLGLQEVLSGLNHSIITAINNGEDLAIAVGTALYGHIKESLMQVFTWATNELIAQQLEPILTKVRDTIMNAIIQGSDINFDTLIDIEQLIQVGRQAEKQAQMMEELINKYKEALREAGIDEEIIDQLFPMTEAEQKAEELAQTVSGALRNALAEALEAGNIRDFSSAMGEAIYTHVKDALIQAFMQSEVYQEMFKKWFDVSDITFTGNLAEDFETIQDILDDLEQQLKAAGLGFNYTTIPMIGNGVTLDQGLYGTESYFAPSTLEAGRDMANTFATAIEQFTIATDSLVRSIDELTDSINYSKSKIQPFIWYRRPEPDLDYSNKQIHNHYHFEPKINNMFDGDKSTLFEEFVAWKRKLEMNQA
>CP016379.1|AZR72545.1|791403_792375_+|hypothetical-protein
MENIEPYLEKAKQGLKEGNYRNFMENISIAKYLTKFHSKNKQEVFYLYIKGLYKLNDYKAAIQVLSEAFPMFEGETKYDLLNLKGLILGRLGDYKDSIQIFEELAKLDEYLSIKIKAINNLAWAYLYLFKVESDPSFLILAAKRCNEAIKKFDLFDDNILKKKILVNLGTAYWFQKKFDQALETFFEAQKFMQDDPKLFNNIASTFARLGNQEKAMEYLKKAELLADKMNNLFEKAQSYRILAELAEFNQDYMQAVDYYLVAYDLYTSIQAFRESLECQDEIDRLTYLIKQESREIMKESWRKKKTNGFDKEIHFTYKKGESR
>CP016379.1|AZR72546.1|793006_793216_+|hypothetical-protein
MFANDQEYEQFLKENVLSTKDAADFLGITRKGISYLVKEGKLRPFKDQDRVRLFSRREIERYKKERDGV
>CP016379.1|AZR72547.1|795593_795947_+|hypothetical-protein
MICYLYGVYEDLNDSICFLISRGFIIYESKKHVNGKNYDKLYYLTLYGVKRIEDDIIKDFSKNLTCAKWYVDKCKIIKEYFGDMSGTELKIRQYRHDEYASTKINDYIQDITDKVRK
>CP016379.1|AZR72548.1|796792_798649_+|hypothetical-protein
MNIKLLLNILVLSFLVILVLFYSNLGEASSKLVWKEYSNQYFKIKYPAEWNKAEAGNRVGFAPINGSIYFGFDIDVVTTEDVSSFEKFQNRFKNQIKKLHSSASEIEVEEISIDGQPAYKILATNSLYQIKGFIISVYKNKTAFDLTFTGTEEEYFNYYNVFEEMINSIKFYNFKVEEEEIKLVKGRKLTSKEAIEDALYLFEKLEEIHPNLYKYYSKQEAYVYFNQIKEEISKKDEISKLELYKLLAPYVASFKDGHTELSIYNEYNSYLEQGGKIFPLKVVIKGDKLFVGEDFAESDISVATEILSINGVSSSEILETMKKNISYDLEGFRIKRLEDDFPMWLWANYGKKDFFAVKFKIKSGEVKSVFLKGIKDIKKKENDFSLSYPDEGVALLKINNFYSERGEKFKTFVDKSFKEIKSKKCKNLIIDLRNNGGGTSILVSYLYEYITNKPYCTVKETRYKLSDYVLEHGEYFKLSQVAKLGNKRVLVEKPELKKPNKNQYKFNGCIYVLIGKGTYSAAVNFAAMVKDFITGILVGEETGGYASYYGNSVDIELPYSGLTLKVATTQNIRPAGYDNGKGVLPDVKVDVDPLMLVQGKDQVLETVLQMIKNKEINQ
>CP016379.1|AZR72549.1|798819_799200_+|hypothetical-protein
MSAKSIDEFDIPVVKKEIDEGVKVIFEENKEETKTVNNEYYYNIEALREILMWILDKYNIEYYTKDEQEYYLKLDDGKIYSINFNQVYNMIDKEHNFFRDFEFNNYITNEKHKEPVESIERLYFTI
>CP016379.1|AZR72550.1|800785_801004_+|hypothetical-protein
MKNIKEWKIWKVLRKQLRRMGYQGDFKKISITRWKNSASPLINMALSNRWFDEIGLVNLQRYEVGVLHHYYE
>CP016379.1|AZR72551.1|802490_803819_+|ribosomal-protein-S12-methylthiotransferase-RimO
MISVGLVTLGCPKNQVDSEIMLGLLDQAKFNIVDNLEEADVVIVNTCGFIESAKQESIDTILELSQLKDSGRLKYLVVTGCLAQRYYDELKKEIPEIDTILGTGNFDRIVEVIEEGLKGQDLGGIIRPKFEYRKDLPRIITTPGYTAYVKIAEGCNNRCSYCIIPTLRGPLKSRSIEDILEEVKELVSRGVKEIILVAQDTTVYGIERYGQPMLAALLRKLVEIDGIHWIRIMYSYPDYLTDEVIEIIAQEEKICKYLDLPIQHASDRILKLMNRPTRQKEVEALIKKIRERIPDVVLRTSLIVGFPGETEEDFQQLVDFVRRIRFDRLGVFTYSREENTPADRMKGHLPEEIKKERWNKIMAIQREIALEKNEVMIDKEVEVLVEEVYSEEEGIVIGRTQWDAPEIDNLVYVYNCHAQVGDFIMAKIVDALEYDLVGEEIK
>CP016379.1|AZR72552.1|803815_804373_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MNLPNKLSLLRIILVPLFLIFLLVKFNMPYGEYAKYIAIFIFVIAALTDSLDGYIARKHGLITKLGKLIDPLADKMLISGALIALVSLGEVSAWPAFIIITREFAVTGLRAIASAEGVVIAASIWGKMKTISQIIAILAVMIDISIFKIPFDAHEILIWIATFITIISGLDYMIKGWHILRSEKH
>CP016379.1|AZR72553.1|804369_804819_+|hypothetical-protein
MKTLVKWLGLGLGTGLSPKAPGTVGSLLALVIAANIKIVHASYFLLISIIAGVLICELTERELGCKDDSRIVFDEMVGQWIAVAGFTGYYLIAGFILFRIFDILKPPPVRQLQKFHGGLGVMLDDILAGGMSWVILILIKNLLLLVPVF
>CP016379.1|AZR72554.1|805113_805566_+|hypothetical-protein
MAQNLLSVNHQQIVEMEEMLDRLEERLLKYEIEEEMVNELVEIGYWANELLQSRISYRERQSLVNLIQRVRYLQILYLESFLNLRVNQLSQELKGLISDQAWQIYLRLDELRGMEREFFKEKDYHLDFNTDLLNLEQELIARLVLLKLTT

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP016379_9	9.1|722301|48|CP016379|CRT	722301-722348	48	CP016379.1	729011-729058	0	1.0
CP016379_18	18.1|730460|35|CP016379|CRISPRCasFinder	730460-730494	35	CP016379.1	717309-717343	0	1.0
CP016379_18	18.1|730460|35|CP016379|CRISPRCasFinder	730460-730494	35	CP016379.1	738292-738326	0	1.0
CP016379_7	7.1|721570|35|CP016379|CRISPRCasFinder	721570-721604	35	CP016379.1	717309-717343	1	0.971
CP016379_7	7.1|721570|35|CP016379|CRISPRCasFinder	721570-721604	35	CP016379.1	738292-738326	1	0.971
CP016379_21	21.4|737564|37|CP016379|CRT	737564-737600	37	CP016379.1	715714-715750	2	0.946

1. spacer 9.1|722301|48|CP016379|CRT matches to position: 729011-729058, mismatch: 0, identity: 1.0

gtaggttgcaacgctcgaattaaaccagatttccattacggacagcaa	CRISPR spacer
gtaggttgcaacgctcgaattaaaccagatttccattacggacagcaa	Protospacer
************************************************

2. spacer 18.1|730460|35|CP016379|CRISPRCasFinder matches to position: 717309-717343, mismatch: 0, identity: 1.0

tttgtcaacccgcctgttagtataggtgggttttt	CRISPR spacer
tttgtcaacccgcctgttagtataggtgggttttt	Protospacer
***********************************

3. spacer 18.1|730460|35|CP016379|CRISPRCasFinder matches to position: 738292-738326, mismatch: 0, identity: 1.0

tttgtcaacccgcctgttagtataggtgggttttt	CRISPR spacer
tttgtcaacccgcctgttagtataggtgggttttt	Protospacer
***********************************

4. spacer 7.1|721570|35|CP016379|CRISPRCasFinder matches to position: 717309-717343, mismatch: 1, identity: 0.971

tttgtcaacccgcctattagtataggtgggttttt	CRISPR spacer
tttgtcaacccgcctgttagtataggtgggttttt	Protospacer
***************.*******************

5. spacer 7.1|721570|35|CP016379|CRISPRCasFinder matches to position: 738292-738326, mismatch: 1, identity: 0.971

tttgtcaacccgcctattagtataggtgggttttt	CRISPR spacer
tttgtcaacccgcctgttagtataggtgggttttt	Protospacer
***************.*******************

6. spacer 21.4|737564|37|CP016379|CRT matches to position: 715714-715750, mismatch: 2, identity: 0.946

agaagaaattggatgggataaggaatataagcttttc	CRISPR spacer
agaggaaattggatgggataagaaatataagcttttc	Protospacer
***.******************.**************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP016379_22	22.2|738486|33|CP016379|PILER-CR	738486-738518	33	MN693779	Marine virus AFVG_250M346, complete genome	56901-56933	9	0.727

1. spacer 22.2|738486|33|CP016379|PILER-CR matches to MN693779 (Marine virus AFVG_250M346, complete genome) position: , mismatch: 9, identity: 0.727

aggaggagaatatccagaagaaatacatgttgg	CRISPR spacer
tctaggagaatatccagatgaaatatattggga	Protospacer
   *************** ******.**   *.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2126042 : 2133647	7	Burkholderia_virus(16.67%)	NA	NA
DBSCAN-SWA_2	2893523 : 2901901	8	Synechococcus_phage(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP016379|2126042:2133647|DBSCAN-SWA
TTTAATAACTTAACATTACATTAAATACTCCTCTCCTTAGATTCATAACATTTGGAACACCATATCCAATCCTTTTGATCAATTTAATCTTGTTATTGATACCCTCAGCAAAGCCATTGGTTATCTTAGTCTTAAAATAATTTAGTATTTTTCCTTCCCATCTTTGTATTATCTTTTTTACCTGGTAAAAAGGCATCAGCTTGCTTTTTATTACTTCTTTATACCACCTTTTTAGAGCTCTGGTGGCTTCTTTCACATTATCTAGCTGCAATAGGTCTCTGAATTCCTCTTTTAATTCCCAGGCCTTTTCTAGAGCTGGACTGAGTTCAAATAATTTGATGAGCTTTTCATGTTCTTCATCTGTCAATTCTTCAGCTCGTTTTTGGAGTAATAAACGACTTTGAAAAAACTTTCTTCTCTGATGATTATTTACTGTTTGTTGAACTTGTTTTCTAACTTCATCAAGGGCTCTGTTCATTAAAGTTACAAGGTGAAATTTATCTATAACAATTTTTGCATGAGTAAATGCTGCATCTGCTACTGCTTTAAACGGCCGCCACATATCCATAGAGATTGATTGAATCTGTCGTCTTTGCTCATCTTCCCAACAATTAAAGTAGTTAATTAAATCATCCTTTTTGCGAGTAGGTAAAATGTCAATTAACTCCCGATTAATTGGATCTGTAATGCTAACTCCATATTTATGGCGTTTTAAAACTGCAAATTCATCGATACTGATGGCTTTTAATTGACTAAGTTTTGAAACTTGTTGTTTGATAAGAGGGTCAATTACTTTTTTAACTGCATTATTAACAGCTGTATAACTTAACCCGTTTTCTCTAGCAACTTTAGAATAATCCTTGCTGACAGTTTCTTTAGCAAGACATTTATCAAAGCGTTTGGTATTACGGGCATATTTATCAATACTTTCATATTTTTCAGGGATGCCCCTCTTATGACAATAAGGACAACGATATCTTTTCTTTAGAAGTCTAATGATTACTAGTTTACCTCTTATGGGGATGTCTCTAATATTTTGCCATTTTGTATCATGGATTTTATTAATGATATTACCACACTGAGGACACACAATGTGATTTTTCTTTGCTTCAGCAATAAAAATATATCTGTCCTCCGTTGAAATAATTTCAGTTGCAATAATGTCTGGCAAATCAAGAAATTTTATGATATTATTATATTGCATTTGCTGGACTCCTTTCTTTGGTTTTTAGTTCGCAACTTAATTAATTCAACGGAGCCAGCAAATGCCTTTTTATTTTTTATAATTTTTTCTTCACAACATTAATTATAGACCCAAAAAGAAAAAGGTTACTCAAATAGAGTAACCACAGGCTGTTGAAAAAGGAGTGGTGCACATAACTTGCTCCCACAGAGGAACAAAAAAACCAAATATAATTTCTTCTGCTACCGGATGCTTCGCCATCCTGGCTGCGCGTCCTTAAAAGTCAAGACTTCCGCCATCCTGGCTTTAAGCCTTGATTTATACGTTTCAGAAATTATATTTAGTTTTTCTGACAGTGCACGGGCAAGTCTCTAAAAAAGAAAGGTTTGTCAACAAGCTCAGGTTACTCAAATAAAGTAACCAAATAAACTATTGATAAAAATAACCAATTATATATAGTTCTTTTCGACTCTTTTTTAATTTTTACTCAATTGCAATTTTATATTTCTATTTAACTCTGCAAAATAAATTCATTATCAAACCCAAAATATTTTACACAGAGTTTTCCAGCACGATATACCACCTCCTGAGGTACACAGACATAAAACCGCCAAAGATTCTCATACTGATCCTCTAGCACTTTTACATCTACCGGCGGATTTATGCGCGGTTCATTCAGGCGGTGAATTCCTAAACTCGTTCGGGCCAGGGCAGCAGATTCTTTCATTACCCACTCGTTAGGACAGTAAATCAAAACCTCGGCTGCTGATATTCCCAACTCGTTTGCCAGTTCCTCTTCAGCCCTGGCTCTATCACCACCCGGGCCAGTATAAATTTTAATCAAATCCCGTCTCTCTTTCCGCCCTAACTGCCCTGCCGAGAGAACATATGCCCGTTTTAAAAAACGCCTTGACTCAAAGCGCCGCACCAAATCTAAGATCCGAGAATCATTCTCTTCTTGACCAATCTCCTTTAACTTTTCCAATAAAGTATAATCATTGCATCGTAAAAGATCATCTTCTGTAAGACCATAGTCAACAGCCAGTTCAACAGCTTTAGCAATCATAGCACCAGCAATAATTTTAGTATGATGAGTATATACCCTTTCCATCATAAAATACCTGAACCGTAAAAGATGCAAGATCTCAGAGCGGGCATCCAACCGATCCATTCCGTGTTTGACCATATTCAAGGCCAGTTGATCATTTAAAATAGTAAAATAGCTAAAAACCCGTTCATCATAATCATGAGCAATACCAGCAAAATAAGCATCCCGTTTAAGATAATCTAACACATCAGCATCCAGTGTACTGCTAATAATATCTCTAGCCCATTTGGGAAAATATTTAGATTCACCACTTCCCGTTAATATAGCCATCACTTTTTCCTTTAAGTTTAATCTCTCCAATACCTTTCCTACTTCACCACTGTCTATCAACTTTTCATAGCGGTTTCTAGAATCGTGGCGGGGAAAAATTTGTCGTTCATCTTCTAAAGTATGACCATAGGGTAAATGGGTAATATCGTGGAGAATGGCCCCTATCGTAATAATCTCTTCAATTTCAGGATCAATTGTATGACCGTTCCAGCGGAGTGCCTGCAAAATTTTTTTCGCCGTATGGGCGGTACCCAGAGAATGATCAAACCGGGTATGAACACAGCCCGGATATACTAAATTAGCAGTACCTAACTGCTTAAGACCCCTTAACCGCTGAACTTCATATGTATCTATTACCTGTACTTCTCTGTCGGTAAAGGATATGTCACCATGAATGGGATCCCGTAAAATCATAGACTTTTGCTCCTTTCTTTTTCATATTTACCATGATTGAATTAGGATGATGGTAAAAATCAAAAGAGTAAAACCTTTGAAATGAACCATGATAGCAGACTTCTTTCATTCACTTTCGCCCCTCTCAAATTAATTTTTAAAATCCTTTCATGTTTTCATATTTCTGATTTTACTACAAAAAGCTAATTTTTCGCTTTAAAAGAAATTTTTCGAACCATCTAAAGTTCGATTTCAGTGACTTGATTAGCTCATCACATCCTGTAATGAGGCCTTATTTCGACTGAAATCTCACTAAGGATGGTTTAACGAAAAATTTCTATATCGCTCAAAATTAGCTTTTTGTAGTTTAATCATTTCTTTATAAATAATATTTTCCCTTTAATTTTGGAATAATTAAACTTAAACTAAACTCCTTTCCGATATGAAAGTTCAATCTCCTCACCTGGTCAAATAAAAAATGCTGAACCAATTTCTTAGTTCAGCATTTTTAAAGCTAAATACAATTTGTCCATAATTCTAATAAGCAAAAACATGAGCGCCAATCCGGGTTGAAACCGGCCTTGTTGCTAACCAGGTTCGCTTAGCAATCCGTGGATTATAAAAGAATAAAGCACCATAGGTTGGGTCATAACCCAAAATGGCTGCTTTGGCTGCTTCAATAGCAGTATTGCTGGGATAAAGATGAACCTGTCCATCTATAAGGCTGCAAAATTGACCATCCTGAAGAATTACCTCCCGAATAGTGTTTGGAAAAAGCTTACTATCAACCCGATTTAAAATCACAGCTCCTACTGCTACCTGTCCCTTAAAAGGCTCTCCCCGGGCTTCAGCATGAATTACCCTGGCAAGAAAGATTAAATCTTCCCAGGAAAATTGGCCCCGTGTAGGATACTTGTCCGATTTTGGTAAAGCTTTATATGTCTGTGGGCCAACTACACCATCAACTATAAGCCCATTATCCTTTTGAAATTCACGCACTGCTTTTTCCGTCATTTTACCAAATATACCATCAATTCTTCCATGATAATAGCCTGCTTCTTGTAAACGGAACTGTAAAATGGCTACATCAGGCCCCTCATTTTTATATTTCAATATTCGTGTACCAAACTCTATCATCCGGGTCTCCTCTGCATAACAGAGTCCAAATACCAGAAATACTATACCCAGACAAAAGAAAAAACGAAGCAAAGGTTTCATAACAAAACCCCCTTCCAGACATAATTAGATTGTCCATTTTCAAAAAAAACTATCCAAAATAGAATAACCATCAACCAGGTGGTCAAGGTGTTATAATTTATCTATAAAAATATTGAAACAATCATAATTAATCTTGATCGTTTATTCCTAATATACCTTTATATTCCAATTTATCAAGTACCCATTTTTCTAAACGCCTCATAAAACGTGTCCAGAAAAATTCTTTTTCTGACATCGGTTTTACCAGAATAGTTTTTAAACCTAACCGCTTACCACCCAGAATATCAGTAAAAAGTTGGTCACCCACAACTAAAATCTTTTCTTTGCTCAGCTGAAGCTTATCTATTGCTTTTAAAAAAGCTTTTTTACGAGGTTTGCCAGCAGCAGGTACTGCATCAATAGCCAGTTTCTGTGCAATACTATTAACTCGATTATGAAGACTATTGGAAAGGAGACAGAAGCGAATTCCATCTTTTTTTAGACTTATAACCCAGTTTATCATCTCCTCACTCAAAAATTCCTCATCCCACGGAATAATGGTATTGTCCAGATCACAAATTATTCCTTTTACTCCCATCTCTTTCAAATATACAGGCTTAATTTCTAAAATATTTGCTATAAACAGATCTGGACACAGATATTTAAACAACTTCCATTCACCTCTACATAAGTTAATTATTTCAATACCCTTCATCGATTAAATTATAACATATTTATACATAAAAAGAAAGAGAAAAAATGCTATTTTATTAGCCCTCTTTTTTAAATTTCTTTACCAACTTTTGAACAGCTTTTTTTTCAATTCGGGAAACATAGGATCTGGATATGCCCAATCTTTTGGCTATTTCCCGCTGGGTATATCGTTCCCCATCTTTAAGTCCATAACGCATTATAATTACTACCCGCTCGCGGTAGTCCAGTTCTTTTAAAAGGTCATAGAGTTTTTCCTCATCTAAGTTTAATTGAACCCGGTTACAGATCATATCAGGTTCAGTTCCTAAAATGTCCATCAAAGTTATCTCATTTCCCTCTTTATCAGAGCCAACAGGCTCATGTATTAGCATTTCGCCCTGTAATTTTTTGATAGAGCGTAAATGCATTAGAATTTCATTTTCAATACAGCGGGCAGCATAAGTAGCCAATCTGGTATTTTTTTTATTATCAAATGTCTGGATAGCTTTAATTAAACCTATTGTACCAATAGAGATCAAATCCTCTGTTTCTTCTCTGGTATTCTCAAATTTTTTAACAATATGAGCAACCAGACGAAGATTATGTTCAATCAGAATATTACGGGCTTTAAGATCCCCTTTTTTCATCTTTTCTAAACATTCCTGTTCTTCTTTTTGAGATAAAGGCTGTGGAAAAACATTATTAGCTATATATGAAACTAACAATAAAATTCCTTCAAACAAAGAAAGACCTAATATGGTCAGCAAAAAAAGCACCATATCTACACCTCCTAATAGCTCTAATAGTATCATATGAGGAGGTATAGAAAATAGTGCCTGTCTTCAAATGATAATTTCTGACTGAAATCTAATCTGCCTCACGCTCCGGTTTCTCACGCCGTACCATATCAAATCGCTTCACCGGATATTTTACCGGAATCCGGATTATTTGATGAGGATGTGGCGCTTCCTCAATCTCATTATCATCTTCATCTTTAATATAGGTAAGTTCGGTGGTAAATACCCTGGTTTGGGGTCCAAAAATTTCAACCCGGTCACCTTTGAAAAATTTGCTCCTGACCTCAACCACTGCCTCTTTGGTTTCAGGAAGATAATCACGAACAAATCCCATAAAATCGTAGTTGCGAACATAAGCAGAGGTTTCATAATTATGATCCTCTGGCCCCGGTGGATCAAAATAGAACCCGGTGGTATAATGACGGTGGCTTACTTTTTTGAGTTCTTCAAGCCAGATAGGATCAAATTCGTAATTTTCCGGGTCTTTTACATACCGATCCACAGCCTGACGGTAAACATAGGTAACAGTAGCTACATAATGAAGGCTTTTCATTCGGCCTTCTATTTTAAAACTATCCAGACCTGATTGAACCAATTGAGGAATATATTCGATCATACAAAGATCTTTGGAATTAAAAATATATGTACCCCGTTCATCTTCAAAGACGGGATAATAATGGCCCGGACGTTTTTCCTCTACCAGAGCATATTTCCAGCGACATGATTGAGCACACTTACCCAAATTAGCATTCCGGTTAGCCATATAATTGCTCAATAAACAGCGACCGGAATAAGAGATACACATAGCTCCGTGCACAAAAGCTTCAAGTCCTACCTCAGGAACCTTTTTTCTGATCTCTTTAATTTCTTTTAAAGAAAGTTCACGGGCCAGGATCACCCTATCCACACCCTGTTCATGCCAGAATTTGACACTCCGCCAATTAACGGCATTGGCCTGAGTACTTAAATGAATTTCCATCCCGGGAATAACCTCTTTAACCATAGTCAAAATTCCCGGATCAGAGACGATAACAGCATCCACACCAAGATCAGCCAATTGTTTTAAATATGTAGGCAGATTAGCAAAATCCCGATTGTGCGGAATAATATTTACCGTCACATAAACTTTTACACCTCTTTTATGAGCAAATTCCAGACCTTCTTTCATCTCTTCTATAGTAAAATTATCAGCACCTTCACGTAAATTAAAAGCCTGTCCTCCCAAATAGACAGCATCAGCGCCATAAAGAACAGCTACCTTAAGTTTTTCTAAATTGCCGGCAGGCGCCAGTACTTCAGGTTTTTTCATCTTTTCCTCACTTCCTTTAAACTCAATGCCATTCCATCACCAATAGGTACAATTGCTGAAGTCAATTCTGGATGGTTCATCACCAATTTTATATAATCGGTCATCCTGTTCACCATAGTCTTCATCCGGCGATGGGGAATTAACTTATGATTTGCTACCCAACCGTTCAATAACACATTATCAGCCACAATTAATCCTCCTGGATTGAGAAGGTCAATGACTTCTTTAAAAAAGTTTAAATACTGACCTTTCGCCGCATCCAAAAAGATTAAATCAAAAGAAGTATCCAGTTTGCCGATCATATCAATGGCATCTCCCACGATACTCTGTATCTGCTTCTCAATACCGGCTTCTTTAAAATTAAGCCAGGCCTGATAAGCCCTATCTTCATTAATCTCAATGGTTTTAATCTGCGTTTCGGGTCCGGCAGCCCTGGCCATCCAGATGGTAGAATAACCGATGGCCGTACCCACTTCCAGAATAGATTTGGGCTTTTGAAGCCGAATTAAAAAGTATAAAAACTGTCCCACTTCTGGATAAATGATAGGAATATGTTCACAGGCCGCCTGCTCCTCCAGCTTTTTTAAAAGGGGATCACGCGGCGGCACCGTATCTTTTAAAAATTTCTGTAACCAATCAGTTATAAATTCGCTCAT

Protein sequences of DBSCAN-SWA_1

>CP016379|2126042:2133647|2130340_2130862_-|AZR73617.1|DBSCAN-SWA
MFKYLCPDLFIANILEIKPVYLKEMGVKGIICDLDNTIIPWDEEFLSEEMINWVISLKKDGIRFCLLSNSLHNRVNSIAQKLAIDAVPAAGKPRKKAFLKAIDKLQLSKEKILVVGDQLFTDILGGKRLGLKTILVKPMSEKEFFWTRFMRRLEKWVLDKLEYKGILGINDQD
>CP016379|2126042:2133647|2126042_2127245_-|AZR73614.1|DBSCAN-SWA
MQYNNIIKFLDLPDIIATEIISTEDRYIFIAEAKKNHIVCPQCGNIINKIHDTKWQNIRDIPIRGKLVIIRLLKKRYRCPYCHKRGIPEKYESIDKYARNTKRFDKCLAKETVSKDYSKVARENGLSYTAVNNAVKKVIDPLIKQQVSKLSQLKAISIDEFAVLKRHKYGVSITDPINRELIDILPTRKKDDLINYFNCWEDEQRRQIQSISMDMWRPFKAVADAAFTHAKIVIDKFHLVTLMNRALDEVRKQVQQTVNNHQRRKFFQSRLLLQKRAEELTDEEHEKLIKLFELSPALEKAWELKEEFRDLLQLDNVKEATRALKRWYKEVIKSKLMPFYQVKKIIQRWEGKILNYFKTKITNGFAEGINNKIKLIKRIGYGVPNVMNLRRGVFNVMLSY
>CP016379|2126042:2133647|2129532_2130213_-|AZR73616.1|DBSCAN-SWA
MKPLLRFFFCLGIVFLVFGLCYAEETRMIEFGTRILKYKNEGPDVAILQFRLQEAGYYHGRIDGIFGKMTEKAVREFQKDNGLIVDGVVGPQTYKALPKSDKYPTRGQFSWEDLIFLARVIHAEARGEPFKGQVAVGAVILNRVDSKLFPNTIREVILQDGQFCSLIDGQVHLYPSNTAIEAAKAAILGYDPTYGALFFYNPRIAKRTWLATRPVSTRIGAHVFAY
>CP016379|2126042:2133647|2131752_2132991_-|AZR73619.1|DBSCAN-SWA
MKKPEVLAPAGNLEKLKVAVLYGADAVYLGGQAFNLREGADNFTIEEMKEGLEFAHKRGVKVYVTVNIIPHNRDFANLPTYLKQLADLGVDAVIVSDPGILTMVKEVIPGMEIHLSTQANAVNWRSVKFWHEQGVDRVILARELSLKEIKEIRKKVPEVGLEAFVHGAMCISYSGRCLLSNYMANRNANLGKCAQSCRWKYALVEEKRPGHYYPVFEDERGTYIFNSKDLCMIEYIPQLVQSGLDSFKIEGRMKSLHYVATVTYVYRQAVDRYVKDPENYEFDPIWLEELKKVSHRHYTTGFYFDPPGPEDHNYETSAYVRNYDFMGFVRDYLPETKEAVVEVRSKFFKGDRVEIFGPQTRVFTTELTYIKDEDDNEIEEAPHPHQIIRIPVKYPVKRFDMVRREKPEREAD
>CP016379|2126042:2133647|2130962_2131664_-|AZR73618.1|DBSCAN-SWA
MVLFLLTILGLSLFEGILLLVSYIANNVFPQPLSQKEEQECLEKMKKGDLKARNILIEHNLRLVAHIVKKFENTREETEDLISIGTIGLIKAIQTFDNKKNTRLATYAARCIENEILMHLRSIKKLQGEMLIHEPVGSDKEGNEITLMDILGTEPDMICNRVQLNLDEEKLYDLLKELDYRERVVIIMRYGLKDGERYTQREIAKRLGISRSYVSRIEKKAVQKLVKKFKKEG
>CP016379|2126042:2133647|2127735_2129016_-|AZR73615.1|DBSCAN-SWA
MILRDPIHGDISFTDREVQVIDTYEVQRLRGLKQLGTANLVYPGCVHTRFDHSLGTAHTAKKILQALRWNGHTIDPEIEEIITIGAILHDITHLPYGHTLEDERQIFPRHDSRNRYEKLIDSGEVGKVLERLNLKEKVMAILTGSGESKYFPKWARDIISSTLDADVLDYLKRDAYFAGIAHDYDERVFSYFTILNDQLALNMVKHGMDRLDARSEILHLLRFRYFMMERVYTHHTKIIAGAMIAKAVELAVDYGLTEDDLLRCNDYTLLEKLKEIGQEENDSRILDLVRRFESRRFLKRAYVLSAGQLGRKERRDLIKIYTGPGGDRARAEEELANELGISAAEVLIYCPNEWVMKESAALARTSLGIHRLNEPRINPPVDVKVLEDQYENLWRFYVCVPQEVVYRAGKLCVKYFGFDNEFILQS
>CP016379|2126042:2133647|2132987_2133647_-|AZR73620.1|DBSCAN-SWA
MSEFITDWLQKFLKDTVPPRDPLLKKLEEQAACEHIPIIYPEVGQFLYFLIRLQKPKSILEVGTAIGYSTIWMARAAGPETQIKTIEINEDRAYQAWLNFKEAGIEKQIQSIVGDAIDMIGKLDTSFDLIFLDAAKGQYLNFFKEVIDLLNPGGLIVADNVLLNGWVANHKLIPHRRMKTMVNRMTDYIKLVMNHPELTSAIVPIGDGMALSLKEVRKR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZR73614.1|2126042_2127245_-	hypothetical protein	Q6V7R1	Burkholderia_virus	1.8e-30	28.6
AZR73615.1|2127735_2129016_-	hypothetical protein	A0A076FI64	Aureococcus_anophage	4.8e-13	25.4
AZR73616.1|2129532_2130213_-	cell wall hydrolase	A0A0K2FM09	Brevibacillus_phage	6.7e-22	40.3
AZR73617.1|2130340_2130862_-	hypothetical protein	NA	NA	NA	NA
AZR73618.1|2130962_2131664_-	sporulation sigma factor SigK	S6ANS0	Bacillus_phage	3.3e-16	30.7
AZR73619.1|2131752_2132991_-	peptidase U32	Q6DW11	Phage_TP	1.1e-62	40.8
AZR73620.1|2132987_2133647_-	hypothetical protein	S5YRC3	Mycobacterium_phage	6.7e-19	39.7

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP016379|2893523:2901901|DBSCAN-SWA
ACTAATCAAGGCACGTTTCATTTCTGCATTCCTCCTCTGGTAAAATTATGACTCGTCTTCCATCAATTTTCAATCGACCCGCCTGATAGAGGCGAACCGCTTCTGGGTAAATCCGGTGTTCTTCCATCTGAATACGATAAGCCAGCTCATCACGAGTATCTCCCGTATATACCGGAACTGCTGCCTGGAGAATAATTGGCCCTGTATCCATCCCTTCATCAACAAAATGCACTGTACAGCCAGTCACCTTAACTCCGTATTCCAAAGCCTGGCCCTGAGCATCAAGCCCCGGAAAAGCCGGCAAAAGGGATGGATGAATATTCATTATCCTGTTCGGAAAATGGTGCAAAAATACCGGGGATAAAAGACGCATAAATCCGGCCAGAAGAACCAGATCTGCATCTGCTTCTTTGATCATCTTCACCATCTTCAACTCATAGTCTTCCCTGGAATTAAATTTTTCACGTCCGACATAATAGGCCGGAATTTTATTCTTTCTTGCCCTGGTCAAAGCATAGGCATCAGGGTTATCACTGATCACAAGAGCTATCTTTGCATTGAGTTCCCCACTTTTAATGGCATCAATAAAGGCCTGAAGATTTGTTCCCGAACCTGAAGCCAAAACCGCTAAACGGATCGGATCTGACATGCAGCTTCCCCCGCCTTTCTCTGAGTTACCTCACCAATCACATAACTTTCTTCTCCCATCTCACTTAAAAGTTCCTGGATTTCTTTAAGTTCCTCCGGTTTAACTATTAAAACCATACCGATCCCCTGGTTGAAAGTACGATACATCTCCATCTTCTCAACCCCGGATCTTTCTATAATCTCAAATATAGCCGGCCGTGGCCAACTTCCTTCATCAACAACAGCTTTTAAACCTTTAGGTAAAGAACGCGGTATATTTTCCAAAAGTCCCCCACCAGTAATATGAGCAATTCCACCAATGGTAAATCTATCAAGCAAAGCAAGAACCGGTTTTACATAAATCCGGGTTGGTGTCAAAAGTACTTCTCCTAAAGGAAGTCCCAGTTCGGGTAAAACCATATCCAACTCATATCCCCGCTCTTTTGAAAAGATCTTTCGCACCAGAGAATAACCATTACTATGAATACCTGAACTTTTAAGACCCAAAAGAAGATCGCCAGCCCTTACATTTTCCCCAGTAATCATCTTTTTTCGTTCAACAATTCCTACCGCAAATCCTGCCATATCATATTCACCAGGCTGATAAAGATCAGGCATCTCTGCAGTTTCGCCTCCAATTAGGGCACACTCTGCTTTAAGACAACCTTCCGCAATCCCACTTACTAAGGCCTCTATCTGTTCCGGAATTACTTTATTTACAGCCAGATAATCTAAAAAAAAGAGCGGCCTGGCTCCCTGGGCCAGAATATCGTTGACACACATGGCCACAAGGTCAATTCCCACTGTATCGTGACGATCTAAAGCCATCGCAATTTTTATTTTACTTCCCACACCATCAGTTCCCGAAACCAGAACCGGTTCTTTCATTTTTTCAATATCCAGTTTGAAAAGACCGCCAAAGCCTCCGAGTCCTGCTAGAACAGCCGGGTTATGGGTACGGGCCACCAGCCCTTTAATCCGCTCTACTGCCTGATTTCCCGCATCAATATCGACACCTGCATCACGATAACTAAATTTAGACCCCACAACATTTCCTCCCCTCTTCAAGGGAATATTTACCTGTTCCTTTACCTATAGGATAATTACCATCAAAACAGGCAGTGCAAAACCCCAATTCTGTTCTGGCCAGTGCCTTCAACATACCAGCCTGGCTCAAATAAGTTAAAGAATCAGCACCAATATAATTACAAATCTCCTCTACACTCATCCTGGCTGCAATCAGTTCACGCCGATTGGAAGTATCTAAACCATAATAACAGGGATAAACAACAGGTGGTGAACTGACACCAAAATGAACCTCTTTTGCTCCCTTCTCCTTTAGCATTTTGATAATCCGCTTGCTGGTTGTCCCGCGTACAATAGAATCATCTATTAAGAGAACCCGTTTTCCCTTAATAATCTCGCAAATAGGATTTAATTTTAACTTTACCTTTATATCACGAATCTCCGGTTCTGGCGAAATAAAGGTCCTACCTACATAGCGATTTTTTATCAATCCCCATTGAAAAGGAATCCCCTTTTCTTCTGCAAACCCCTGAGCTGCTGAAATTCCAGAATCAGGAACAGGGACTACCACATCAATTTCTGCCGACATTTCCCGGGCCAGCGCCCTTCCCATCTCCATTCTGGCCAGATGTACATTTTGTCCGCCAATTATACTATCAGGACGGGCAAAATAGATAAACTCAAAAATACAGAAGGCAGAATGGCCTTCCGCATACTGAATCGAACAAACACCCTGTGAGTTAATTATAACCATCTCACCGGGTTTAATATCACGGACGTACTCAGCTCCCACAATATCCAGAGCACAGGTCTCAGAAGCTAAAACATATCCATCTCCCAGTTTACCTAAAGAGAGAGGCCGAAAACCATAAGGATCCCGAATTCCGTAAAGATTATCTTTGGTAAGCAAAACCAGACTGAAAGCTCCTTTAATCTGTTTAAGACAGTCCAGAATTGAATCTTCAATATTCTTTTCCCGGGAACGGGCAATTAAATGAGCAATCACCTCAGTATCCAGTGTAGTATGAAAGATAGAACCCTCTTTTTCCAATTGTCTTCTAATCTTATAGCCGTTGACCAGATTTCCGTTATGGGCCAGGGCCAGCATTCCTTTGCCAGAGTTGATTAAAAGGGGCTGAGCATTGCTTAAGAGGCTGGAGCCTGTGGTAGAATAGCGAACATGACCAATGGCTCTATCCCCCTTTAACTTACGCAAATTATTTTCGCCAAATACGGAACTAACCAAACCCATCCCTTTATGAATGCTAAAATCCCCATCCTCAGAAACGACAATTCCTGCACTCTCCTGACCCCGATGCTGTAGAGCATGAAGACCAAAATAAGTCAATTGGGAGGCATTTTTTCGACCAAAGATTCCGAATATGCCGCACTCTTCTTTTATCTTTGGTTCATAATACATGGAATAGCCTCCTCCCATCTGAATTTTAGTTGGGTAACTTCTACTTCAATCCAATTATTAATCTTCAATTTATCACCCTGAACCCGGCCCAATCTTTGGACAGGGACATTATTTACACTACATATAGTCATAAACCGCTCAACATCTTTCTCTTCAATGGTAACTATAATCCGGGATTGGGTTTCACCAAAGAGCAGAGCATCAGGTCGAATTTTATCTTCATCTAATTCAATTACTGCCCCTAACCCCTGTTCAAATGTACATTCAGCAAGAGCCACCGCCAATCCACCTTCTGCACAGTCATGAGCCGATTTTATAATCTTTGCTCTTATTGCATCCAGAACAGCTTGTTGAACTGCTTTTTCCAATTTAAGATCAAGCTCAGGTACCTGACCTGTTTCAAGACCGTAAATTAAAGACAAATACTCGCTGCCGCCCAACTCTTCTTTGTTAATACCAATAAGAAATATCAAATCACCCTCATCTTTAAAGCTTATGGTAACCGCATCTTCAAAATTTTCTAAAACACCCACCATTCCAATAATTGGGGTTGGATATATTGCTTTACCTGAACATTCATTGTAAAAACTAACATTACCTCCGGTAACGGGAGTGTTTAAAGCCAGACAGGCCTCTCTCATTCCGGCAATCGATTCTTTAAATTGATAAAATATCTCCGGCTTCTCAGGATTACCGAAATTCATTCCATCTGTAATGGCCAGCGGTTTGCCACCGCTGCAAACCACATTCCGGGCCGCTTCTGCCACCGCAATCATGGTACCACGACGCGGATTTAGATAACAATAGCGACTATTACAGTCAGTCGAGATCGCAAGACCCCGATCTGTACCTTCTACACGTATAACCGCAGCATCAGAACCTGGAAGAACCACAGTATTACTCCTGACCATATGATCATACTGCCTATAAATCCAGGCTTTACTGGCAAGATTAGGACTACTTATTAATTTAAACAAAATTTCATTATATTCTTCATCTGCCGGTAATGGGATTTGATTTAAGTCAAATTTCTCTACTTCATCCAGATAGGCCGGACGTCTGCTCTCCGGATGGTATACAGGTGCATCATGGGCTAAAGAGCGGGCTGGAAGTTGAGCCACGATTTTGCCATTTTCCTTAATGGTCAAATTGCCATCATCGGTTACCTTACCGATAACCACAGCATTTAAACCCCACCGTTCAAAAATAGCTTTTACCTCTTCTTCACGCCCTTTCTTTGGAACCACCAGCATCCGCTCCTGGGACTCAGAGAGCATAAAGTCATATGGAGTCATACCTTCTTCCCGGGCAGGAACTAATGCCACATCCAATTCAATTCCCGTACCGGCTCTGCTGGCCATTTCACAGGAAGAACTTGTAAGCCCTGCAGCTCCCATATCCTGAATACCAACTACAGCTCCGGTTTTTATCAGTTCCAGGCAGGCTTCCATCAGTAATTTTTCCATAAAAGGATCTCCCACTTGAACCGACGGCCGATTCTCTTCCGAATTTTCGCCTAACTCCTCAGAAGCAAAGCTGGCGCCTTTAATACCATCCCGACCAGTAGCAGCACCTACTATCATAACCGGATTGCCAACCCCGGATGCAGAAGCAGTAACCATATCACTGACCGGCATTACCCCAACACACATAGCATTAACTAATGGATTGCCCTGATAACTTTTATTAAAATAGGTCTCACCGCCAACAGTAGGGATTCCCAGACTGTTACCGTAATCAGCAATCCCCGCAACTACACCGTTAAAGAGGTATTGGACATGTTCATCTGAAAGATCACCAAAACGCAGAGAATCGAGTAACGCAATTGGTCGAGCACCCATAGCAAATACATCCCGTACTATCCCTCCCACACCTGTGGCAGCGCCCTGATATGGTTCGATAGCAGACGGATGGTTGTGACTTTCAATCTTAAAGACGGCAGCCATACCACCACCAATATCGATAATTCCGGCATTTTCACCCGGCCCCTGTAAAACACATTCACCTTCAGTGGGAAGAGTCTTTAATTGAGCCTTAGAATGCTTATAGCTACAGTGTTCAGACCACATTACACCATAGAGAGCCAATTCCAGATCATTGGGTTTACGGCCTAAAATTTCAATAATTCTCTGATATTCATCATAGGTTAAACCATTGGCAGCCAGTTTTTCCTTAAGTTCTGCTGTTAACATGGGAGTTCCCCCTTCTCTGTCAAATATGCAATAATTGAGTTAAAAATTTTACGTCCATCTATACAGCCATTACCCAGCCGATCATCAACTGCCCTTTCTGGATGAGGCATCAGGCCAAAGATATTTTTACTTTCATTGACAATCCCGGCAATATTGGAGATGGAACCATTGGGATTTACTTCATCAGTCACTTCACCTTCCGGGGTAGCATAGCGGAGAAGAATCTGTCCATTAGCTTCAAGCTTTGCAATTTCCTCAGGATTCAAATAATAATTTCCTTCTCCGTGGGCTATGGGAAGCTGGATTACTTCTCCTTTTCTCATCTGATTAGTAAAAGGGGTATCGGCATTCTCCACTCTAAGATAGATATATTCACATTGAAATTTCAGACTCCGGTTTTTTTGCATCGCTCCCGGTAAAAGTCCCGCTTCCAATAAAATCTGAAAACCATTACAAATTCCTATGACCAGTCCTCCCTTTCGGGCAAATTTCTGTACCTCCTCCATTATCGGAGCAAACCGGGCTATTGCTCCTGCTCTCAAATAATCCCCATAGGAAAAACCCCCGGGAATGATAATACAGTCAAATCTATCAAGAGATACTCTATCAGCATGCCAGAGATATTCAGCAGTATGGCCCATAAACTCTACAGCATATTTACAATCATGATCACAGTTGGAGCCGGGAAAGACTATGATTCCAAAATGCATCTTTACTCCTCCTCCAGTGGAAAAATCTCATAGATATAATCTTCTATAACTGGATTGGCCAGCAGACGTTTGCAAATCTCTTCTACATAGGCTTCTGCTGTTTTGACATCATCTAGATTTACAACAAACTCCATAAACTTACCTATTTCCAATCCTTTAACCTTATCATACCCCATTGCCTTAAGGGCCCGGGTAACCGTAGAACTTTCTGGATTTAAGATACCTTTCCGCGGCATAATCTTTAATTCAACTCTAAACATCAGCAAAATCTCCTCCTTTTCTTTTTAACCCCGCACCCGGCGCAAAATCTCCTGATATGCTTCCTCGACCTTCCCCATATCCAGACGGAACCGATCTTTATCCAGTTTATCACCCGTTGATTTATCCCATAACCGGCAGGTATCTGGAGAAATTTCATCTGCCAGAAGAATTTTACCCTCAGGGGTTTTACCAAACTCTAATTTATAATCCACCAGATCAATTCCTAATTTCCTGAAATATTCAATCAAAATAGAATTAATTTTTAATGCTTCCTCTCTTAAGTATACAACCTCTTCAGGTGCTGCAATATTTAAAACCCTAATGTGATCTTCTGTAATCAAAGGATCACCCAGTTCATCATTCTTATAATAAAATTCCACCAATGGAGTTTCCAATCTTATACCCTCTTTAATCCCTAACCTTCTACAGAGACTGCCAGCAGTAATATTTCTTACTACTAATTCAACAGGAATAATCTCTACTCCTTTGACCAGCATCTCCGTATCACTGATTAATTCAACAAAATGATTTTCAACACCTAAATCACTTAACATTTTAAAAATGGTAGCAGAAATCAGGTTATTGTACCTGCCTTTATTATCAATAGTACCTTTCTTCTGCCCATTAAAGGCAGTGGCATCATCTTTAAACTCAACCCAGAGAATACCGGGTTTATCAGTTGCAAAAATTTTTTTAGCCTTTCCTTCATAACGTAATTCTAATTTCTGAATTGCCACAGTAAACATCCCCCTTAGAAATTTTTTAATTTCTCTTTCCACTCACGAACAATGAATTCAGTTTTTTCTACAGCCTGGCCCAGATACCGTTCTGGATTTTGAATCAAAAGTTTTTGTTCATCTGTAAATCGATCCCAATATTTTTTCATCTCCTCATCTTCTAACATCAATTGATAGACTGTCTTACCCGTCTCCTTTGCCTTAAGTGTCTTAAGCCTGACTGCCTCATGGGCATCTGGGTGGCCGTAACCAGCCAGGAGAATATACAGCGGTTCAGCAATAAATGATTCCCGGGTCTTATCAAAATTTGCTTTCATCTGCTCCCGGTTGACCCACATATTACTGATTACCCGGGTCAAACGCCTAATAGAAAGCACCAGTCCAGCAATTATCTCTACCACAAATCGCCCAGATGCAGAATTGGTTAAATCCCTTTGGTGTTCAGAAATCTGGTCCAGATAAAGGGTAACCATCCGCGGCATAAACTCCTTGTACATACTTTTAACATTCTCATAGTTGACGGGATTCCGCTTATGAGGCATTGTTGAAGAACCAATCTGATCAGGTGCAAAATATTCTCCTACTTCATCAATCTCCGTCCTCTGTAAATGGCGCATATCATCTGCAAAATTGGCCAAAATCCCAAAGGTGGAGACAAGAGTATGAACAAAATCCAGAACATATTCAGGTTGAACAATCTGTGATGAAATAGGAGCCGGTTTTAACCCTAACTCAGCTAATACATCCTTCTCAAATTGGATGGGATCATCTATAAATAAAGAACTGGCATTATATGCACCAACTGCTCCAGCCATCTTTCCCCGTAAATTAGCTGCTGCCTTACGGATTTTTTCCATTTGCTGACCTAAACGGCTTATATATAAGGAAAGTGCAAATCCAAAAGTGATGGGCACAGCATGCTGTCCATGAGTCCGACCAATTTGAATAGTCTTCCGTTCAGTCCAGGCAACCTCTAAAAGAACTGTCATCAGATCTTTTAATGCCGGTAAGATTAATTTTTCTGCTGCATCACGATAACGAATCGCAGCAGAAGTATCCATAATATCTACAGAAGTAGCCGAAAAATGAACAAATGGTCTGGCCTCTGGACTCACCCGATTGCGAATACAGTTAACCAGTGCGCGAATATTATGTCTGGTCTTCTGCTCTTCTTTATAGACTTCTTCAGGGGTAATGGTCTTTACAGCTTCTTTTACCTCTTTTACCACCTCAATACCACAAAAACCCCGCTTATGTAACACTTTTATTAATGCCAACTCCACTTCAGCCTGGGTACGGATCACTGCTTCTTCAGAAAGATAATAGGACAAATCTTTAAATTCCTCTTCCGGGATTGAATAACGATGATCCAGCGGGCTTATGTTCTTAAAAATATTTCTCTCCAT

Protein sequences of DBSCAN-SWA_2

>CP016379|2893523:2901901|2896573_2898787_-|AZR74233.1|DBSCAN-SWA
MLTAELKEKLAANGLTYDEYQRIIEILGRKPNDLELALYGVMWSEHCSYKHSKAQLKTLPTEGECVLQGPGENAGIIDIGGGMAAVFKIESHNHPSAIEPYQGAATGVGGIVRDVFAMGARPIALLDSLRFGDLSDEHVQYLFNGVVAGIADYGNSLGIPTVGGETYFNKSYQGNPLVNAMCVGVMPVSDMVTASASGVGNPVMIVGAATGRDGIKGASFASEELGENSEENRPSVQVGDPFMEKLLMEACLELIKTGAVVGIQDMGAAGLTSSSCEMASRAGTGIELDVALVPAREEGMTPYDFMLSESQERMLVVPKKGREEEVKAIFERWGLNAVVIGKVTDDGNLTIKENGKIVAQLPARSLAHDAPVYHPESRRPAYLDEVEKFDLNQIPLPADEEYNEILFKLISSPNLASKAWIYRQYDHMVRSNTVVLPGSDAAVIRVEGTDRGLAISTDCNSRYCYLNPRRGTMIAVAEAARNVVCSGGKPLAITDGMNFGNPEKPEIFYQFKESIAGMREACLALNTPVTGGNVSFYNECSGKAIYPTPIIGMVGVLENFEDAVTISFKDEGDLIFLIGINKEELGGSEYLSLIYGLETGQVPELDLKLEKAVQQAVLDAIRAKIIKSAHDCAEGGLAVALAECTFEQGLGAVIELDEDKIRPDALLFGETQSRIIVTIEEKDVERFMTICSVNNVPVQRLGRVQGDKLKINNWIEVEVTQLKFRWEEAIPCIMNQR
>CP016379|2893523:2901901|2899781_2900489_-|AZR74931.1|DBSCAN-SWA
MQKLELRYEGKAKKIFATDKPGILWVEFKDDATAFNGQKKGTIDNKGRYNNLISATIFKMLSDLGVENHFVELISDTEMLVKGVEIIPVELVVRNITAGSLCRRLGIKEGIRLETPLVEFYYKNDELGDPLITEDHIRVLNIAAPEEVVYLREEALKINSILIEYFRKLGIDLVDYKLEFGKTPEGKILLADEISPDTCRLWDKSTGDKLDKDRFRLDMGKVEEAYQEILRRVRG
>CP016379|2893523:2901901|2899499_2899757_-|AZR74235.1|DBSCAN-SWA
MFRVELKIMPRKGILNPESSTVTRALKAMGYDKVKGLEIGKFMEFVVNLDDVKTAEAYVEEICKRLLANPVIEDYIYEIFPLEEE
>CP016379|2893523:2901901|2898780_2899497_-|AZR74234.1|DBSCAN-SWA
MHFGIIVFPGSNCDHDCKYAVEFMGHTAEYLWHADRVSLDRFDCIIIPGGFSYGDYLRAGAIARFAPIMEEVQKFARKGGLVIGICNGFQILLEAGLLPGAMQKNRSLKFQCEYIYLRVENADTPFTNQMRKGEVIQLPIAHGEGNYYLNPEEIAKLEANGQILLRYATPEGEVTDEVNPNGSISNIAGIVNESKNIFGLMPHPERAVDDRLGNGCIDGRKIFNSIIAYLTEKGELPC
>CP016379|2893523:2901901|2894149_2895196_-|AZR74231.1|DBSCAN-SWA
MGSKFSYRDAGVDIDAGNQAVERIKGLVARTHNPAVLAGLGGFGGLFKLDIEKMKEPVLVSGTDGVGSKIKIAMALDRHDTVGIDLVAMCVNDILAQGARPLFFLDYLAVNKVIPEQIEALVSGIAEGCLKAECALIGGETAEMPDLYQPGEYDMAGFAVGIVERKKMITGENVRAGDLLLGLKSSGIHSNGYSLVRKIFSKERGYELDMVLPELGLPLGEVLLTPTRIYVKPVLALLDRFTIGGIAHITGGGLLENIPRSLPKGLKAVVDEGSWPRPAIFEIIERSGVEKMEMYRTFNQGIGMVLIVKPEELKEIQELLSEMGEESYVIGEVTQRKAGEAACQIRSV
>CP016379|2893523:2901901|2900509_2901901_-|AZR74236.1|DBSCAN-SWA
MERNIFKNISPLDHRYSIPEEEFKDLSYYLSEEAVIRTQAEVELALIKVLHKRGFCGIEVVKEVKEAVKTITPEEVYKEEQKTRHNIRALVNCIRNRVSPEARPFVHFSATSVDIMDTSAAIRYRDAAEKLILPALKDLMTVLLEVAWTERKTIQIGRTHGQHAVPITFGFALSLYISRLGQQMEKIRKAAANLRGKMAGAVGAYNASSLFIDDPIQFEKDVLAELGLKPAPISSQIVQPEYVLDFVHTLVSTFGILANFADDMRHLQRTEIDEVGEYFAPDQIGSSTMPHKRNPVNYENVKSMYKEFMPRMVTLYLDQISEHQRDLTNSASGRFVVEIIAGLVLSIRRLTRVISNMWVNREQMKANFDKTRESFIAEPLYILLAGYGHPDAHEAVRLKTLKAKETGKTVYQLMLEDEEMKKYWDRFTDEQKLLIQNPERYLGQAVEKTEFIVREWKEKLKNF
>CP016379|2893523:2901901|2893523_2894171_-|AZR74230.1|DBSCAN-SWA
MSDPIRLAVLASGSGTNLQAFIDAIKSGELNAKIALVISDNPDAYALTRARKNKIPAYYVGREKFNSREDYELKMVKMIKEADADLVLLAGFMRLLSPVFLHHFPNRIMNIHPSLLPAFPGLDAQGQALEYGVKVTGCTVHFVDEGMDTGPIILQAAVPVYTGDTRDELAYRIQMEEHRIYPEAVRLYQAGRLKIDGRRVIILPEEECRNETCLD
>CP016379|2893523:2901901|2895185_2896595_-|AZR74232.1|DBSCAN-SWA
MYYEPKIKEECGIFGIFGRKNASQLTYFGLHALQHRGQESAGIVVSEDGDFSIHKGMGLVSSVFGENNLRKLKGDRAIGHVRYSTTGSSLLSNAQPLLINSGKGMLALAHNGNLVNGYKIRRQLEKEGSIFHTTLDTEVIAHLIARSREKNIEDSILDCLKQIKGAFSLVLLTKDNLYGIRDPYGFRPLSLGKLGDGYVLASETCALDIVGAEYVRDIKPGEMVIINSQGVCSIQYAEGHSAFCIFEFIYFARPDSIIGGQNVHLARMEMGRALAREMSAEIDVVVPVPDSGISAAQGFAEEKGIPFQWGLIKNRYVGRTFISPEPEIRDIKVKLKLNPICEIIKGKRVLLIDDSIVRGTTSKRIIKMLKEKGAKEVHFGVSSPPVVYPCYYGLDTSNRRELIAARMSVEEICNYIGADSLTYLSQAGMLKALARTELGFCTACFDGNYPIGKGTGKYSLEEGRKCCGV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZR74230.1|2893523_2894171_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.7e-28	37.6
AZR74231.1|2894149_2895196_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.7e-69	46.2
AZR74232.1|2895185_2896595_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.6e-60	34.9
AZR74233.1|2896573_2898787_-	phosphoribosylformylglycinamidine synthase II	A6N228	Microbacterium_phage	8.2e-170	42.6
AZR74234.1|2898780_2899497_-	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
AZR74235.1|2899499_2899757_-	phosphoribosylformylglycinamidine synthase, purS protein	NA	NA	NA	NA
AZR74931.1|2899781_2900489_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3ELR0	Synechococcus_phage	1.2e-42	40.3
AZR74236.1|2900509_2901901_-	adenylosuccinate lyase	A0A1B1ISB0	uncultured_Mediterranean_phage	2.2e-27	26.8