CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP034463	Streptomyces sp. GGCR-6 chromosome, complete genome	4 crisprs	WYL,csa3,DEDDh,cas4,Cas9_archaeal,cas3,DinG	0	4	2	0

1. CP034463

CRISPR-Cas detection and classification

Crispr_ID: CP034463_1

• CRISPR_ID: CP034463_1
• CRISPR_location: 39012-39101
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034463_1

Consensus_repeat	Method
TGTCGTCCCCGCGCCCGCGGGGTTGCTCG	CRISPRCasFinder

spacers of CP034463_1

>1.1|39041|32|CP034463|CRISPRCasFinder
GGCAGTCCTCGGGGGCCGGAGCCACCCCGCCC

CRISPR arrays and Neighbor proteins around CP034463_1

CRISPR arrays

The CRISPR arrays of CP034463_1

>merge|CP034463|1|39012-39101|CRISPRCasFinder
TGTCGTCCCCGCGCCCGCGGGGTTGCTCGGGCAGTCCTCGGGGGCCGGAGCCACCCCGCCCTGTCGTCCCCGCGCCCGCGGGGGTTGCTC

>CP034463|1|1|39012-39101|CRISPRCasFinder
TGTCGTCCCCGCGCCCGCGGGGTTGCTCG	GGCAGTCCTCGGGGGCCGGAGCCACCCCGCCC
TGTCGTCCCCGCGCCCGCGGGGGTTGCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034463.1|AZP14735.1|34034_35165_+|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl|CDD|99740
CP034463.1|AZP14736.1|35161_35581_+|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|319971
CP034463.1|AZP14737.1|39176_40124_+|IS481-family-transposase	unknown	unknown	gnl|CDD|366234
CP034463.1|AZP23007.1|35599_36772_-|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	unknown	unknown	gnl|CDD|234825
CP034463.1|AZP14732.1|29572_30820_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197775
CP034463.1|AZP14743.1|52192_53473_-|hypothetical-protein	unknown	unknown	gnl|CDD|374474
CP034463.1|AZP23006.1|33039_34035_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|237195
CP034463.1|AZP14729.1|26857_27613_+|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14734.1|32008_33025_+|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl|CDD|187557
CP034463.1|AZP23009.1|51644_52157_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
CP034463.1|AZP14741.1|46131_47142_-|hypothetical-protein	unknown	unknown	gnl|CDD|176459
CP034463.1|AZP23008.1|50454_51636_+|hypothetical-protein	unknown	unknown	gnl|CDD|271175
CP034463.1|AZP14742.1|47923_49141_+|site-specific-integrase	unknown	unknown	gnl|CDD|271175
CP034463.1|AZP14730.1|28913_29138_+|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14731.1|29051_29582_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379326
CP034463.1|AZP14740.1|45405_46089_-|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14738.1|40238_42272_+|NACHT-domain-containing-protein	unknown	unknown	gnl|CDD|227922
CP034463.1|AZP14739.1|43730_44726_+|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|185714
CP034463.1|AZP14733.1|31063_31627_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
CP034463.1|AZP14744.1|53837_54920_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034463.1|AZP14735.1|34034_35165_+|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl|CDD|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	1.92666e-108
CP034463.1|AZP14736.1|35161_35581_+|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	8.11905e-44
CP034463.1|AZP14737.1|39176_40124_+|IS481-family-transposase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.29934e-15
CP034463.1|AZP23007.1|35599_36772_-|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	gnl|CDD|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	3.57953e-115
CP034463.1|AZP14732.1|29572_30820_-|XRE-family-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.24304e-05
CP034463.1|AZP14743.1|52192_53473_-|hypothetical-protein	gnl|CDD|374474	pfam16289, DUF4935, Domain of unknown function (DUF4935). This family consists of uncharacterized proteins around 350 residues in length and is mainly found in various species, such as Prevotella, Pseudomonas, Leptospira and so on. The function of this family is unknown.	4.94108e-13
CP034463.1|AZP23006.1|33039_34035_+|ATP-grasp-domain-containing-protein	gnl|CDD|237195	PRK12767, PRK12767, carbamoyl phosphate synthase-like protein; Provisional.	6.68127e-75
CP034463.1|AZP23008.1|50454_51636_+|hypothetical-protein	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.08343e-05
CP034463.1|AZP14734.1|32008_33025_+|dTDP-glucose-4,6-dehydratase	gnl|CDD|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.53025e-163
CP034463.1|AZP23009.1|51644_52157_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000187945
CP034463.1|AZP14741.1|46131_47142_-|hypothetical-protein	gnl|CDD|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	3.89884e-32
CP034463.1|AZP14742.1|47923_49141_+|site-specific-integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	6.96649e-18
CP034463.1|AZP14731.1|29051_29582_-|N-acetyltransferase	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.9866e-09
CP034463.1|AZP14738.1|40238_42272_+|NACHT-domain-containing-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	6.11246e-09
CP034463.1|AZP14739.1|43730_44726_+|ATP-dependent-DNA-ligase	gnl|CDD|185714	cd07905, Adenylation_DNA_ligase_LigC, Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases. Bacterial DNA ligases are divided into two broad classes: NAD-dependent and ATP-dependent. All bacterial species have a NAD-dependent DNA ligase (LigA). Some bacterial genomes contain multiple genes for DNA ligases that are predicted to use ATP as their cofactor, including Mycobacterium tuberculosis LigB, LigC, and LigD. This group is composed of ATP-dependent DNA ligases similar to Mycobacterium tuberculosis LigC. ATP-dependent polynucleotide ligases catalyze phosphodiester bond formation using nicked nucleic acid substrates with the high energy nucleotide of ATP as a cofactor in a three step reaction mechanism. DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Members of this group contain adenylation and C-terminal oligonucleotide/oligosaccharide binding (OB)-fold domains, comprising a catalytic core unit that is common to all members of the ATP-dependent DNA ligase family. The adenylation domain binds ATP and contains many of the active-site residues. The common catalytic core unit comprises six conserved sequence motifs (I, III, IIIa, IV, V and VI) that define this family of related nucleotidyltransferases.	4.89786e-63
CP034463.1|AZP14733.1|31063_31627_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	9.17657e-18

Protein sequences

>CP034463.1|AZP23007.1|35599_36772_-|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase
MYNDHRRYFRLMVTGGGTGGHTYPALTAVRTLQSRLAAQGAGLDVVWVGEADSLESRVAVGEGIRFESVAVGKIRRSKNPIKLVSPANIADMSRVPLGVLQARKAITGFGPDVVLATGGYVAVPVGVAATRLCRVPLVVHEQTVRLGLANRTLAGAATRVAVSSPSTLPLLPESVRAAAVVTGNPVRPEVFTGQAQKAIHALGLHGFDARLPTVYVTGGAQGSQQVNHLVRDVLPWLLEHANVIHQCGPGNVDELRRQTAQLPAASAGRYHLAGYMGAELPDVFALADVVISRSGAGTIAELTALGKPAVFVPLATSAGNEQVHNARHLADAGAAVALTGEVTPGQLRAAVAPLLTDPERRAAMAERARAHGRPDAAERLVDVVLAAAGR
>CP034463.1|AZP14736.1|35161_35581_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MRNILTVCLGNICRSPYAASVLQHRGSWAVDARSAGLSDKWTGQPAHEEMLELAAARGFDLAGHRATQVTPELLEWADVVLAMDYKVLDELRRQADPTVFGKITFYLDDQDVPDPYDGTTDDFARAADLIQQGAHRHLP
>CP034463.1|AZP14735.1|34034_35165_+|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MGAVPLQVTMNARPYLHGPEAEALTEALQAGQYGHSAIVDRFEQAIADYLGVPDMVAVASGTAALQLALTTAGVAPGHEVIVPSQTFCASIHAILATGAHPRFVEINPDTLCTDAANVRDALTPKTRAIVPVLYGGRAVDLSTLHDELTRQRITIVEDAAHAFGSHCKDTFVGARPGVLTCFSFGPIKNLTCGTGGGIIPRTPPEAQELRTLRALGIVQSQTQRAATTSYTVQEFGLRATMSALNAAIGLAQLEHFEKVAAKRQELWRTYADGLHALDGVRLVDVDIDHTVPFNCVIHLTDRDRVFAALRASGLGVGVHYPPNHHQPAFKHWHRPLPVTERSARQLMSLPFHPSMNRDDVQYVLSALARSLATETP
>CP034463.1|AZP23006.1|33039_34035_+|ATP-grasp-domain-containing-protein
MRVLVTGTGGAPGFDLARHLIRLGCQVIAADANPLACGLVLAGVTPCLLPSSDDPDFGARLLDVCRRLRPEALISTIEWELPVLIAQREALAALGVRTWLPDAGTVTVTGDKAAFHSALTARGIPTPATWLPHQLDTAAVPGPFVVKPRRGHGTQNVHVCRTRAQAAVLCELVPDPVVQEHILGQEFTADCLVDRTGNASVILRHRLLVKAGLSVVGRTFHDDEAADLVKRTLDAVGMIGPCCVQGFQCAYGGVTVTEVNARFAGGFPLAVAAGAALVEQTLNGLLELPVDHTRLAYTPDVCLTKCFETVATGAWPPPPLHGLTEPAEGAS
>CP034463.1|AZP14734.1|32008_33025_+|dTDP-glucose-4,6-dehydratase
MEKILVTGGAGFIGSHFAARMLACEDVAKLTVIDALTYAGHKENLAAVLTSPKLSFVRGNILDQHLVDELVQRHDAVVHFAAESHVDRSFLEAGTFLTTNILGTHTLLDAARRHGVTKFVHVSTDEVYGPMPTGCATEQCALNPTVPYASSKAASDLLALSAFLTDGVPVCVTRSSNQYGPQQHPEKIIPLFITNLLKGQQVTLHGQGQHVRNWLHVQDNCSGIELVLRRGIPGEVYNIGGGTDQTSRELTGHLLRLCGADWNAVTYVPDRKCNDVRYAMDWSKARDDLGYRPVWSLMDGLAQTVDWYRAHPERWAPASRNTDAPMAALSITDTGEKK
>CP034463.1|AZP14733.1|31063_31627_+|ATP-binding-protein
MIAARLTPSGARRYTETLACEPASARRARLLVSAAVNAWGISEMSEAGMQIVAELVNNAVEHTRCRSVRVLVTRTTERRVRIAVADTCRETPEMGRPDGDAEGGRGLLLVDALSSRWGYDRDPLGKVVWAELEVPPTAEHQFAEALSLGTRTSRPRGDDAPPGSAPPSGSAAPCSHKAAPSAPRPPR
>CP034463.1|AZP14732.1|29572_30820_-|XRE-family-transcriptional-regulator
MAANAVLKRRMEELGLTQDELAGRMNTALAEITGRPGDVSARTVRNLLNGTSRRPIGRTCAALERVFGCSVQDLGFSAPRTMQHPQEDPVRRRTFIASATGTASAAVPLLAQRRTVGMSDVARAAKGMNALVTADQHQGGHTNLEMAALRGRNRVLELQQRNASERVRRALYALAAEYTDAAAWSCIDARNLDQAQKYLNESSTYAGLSQDGPTQMSVWVSMAIFAAQRRNWPEALSAAQAAQASPAARADLFFASLGRIRAALAYAALGDSRAALRSLGSAQEALAAAPERERPRWTTFYCQAELDHLGAIVNHRSGRYTHAEAMAHRALAKIPPSFRRNRALATAQLALAQLHQGDSEQATATAADVFTVMAGTPLPGRMRTLIGDFHRALFTMAPSATYARDWADRLRTEWS
>CP034463.1|AZP14731.1|29051_29582_-|N-acetyltransferase
MELNVIEMRHFRHGHLPEGFRQLLIDVHADAYADQMDDPFNQRFDWFVEHWSSAEGFTCVVAYDGDQPAGFAYGAPATPGREWWRDAKYEPKAGRTSTYSVSELMVRPKWRKQGISERLHEALLKERTEDLAVLLVEVDHPKVQALYESWGYVKVGERQPFADSPLFAVMVKDLPG
>CP034463.1|AZP14730.1|28913_29138_+|hypothetical-protein
MLTSCLTDYCRHELTLCGIFTGREPPLSTPPSPAASKPLAHARWTASAWQVLNHDGEQWGVGKGLSFPDLHVAP
>CP034463.1|AZP14729.1|26857_27613_+|hypothetical-protein
MTSRREPRLADAAQIAAEHDLTPARISSLYTSREHNTAGQTFPEPVATRGRARLWDHAEVTEWFAHRTPTRLKGYKPPARDPQELLNAAEASRFLGYKNPNQVTTFVRDHPGYFPDPDVVEELGTPDNPYRRQQWRVQTLLNWLESRPGRGRRAGTKPAPPLPDVPVDGDPDELLGASEAAALLGYKSLSSFSSSLSQGNLPLLKTTDGIAENAGRQNGRRRWTRRRILEQAAQRSRRWAPAVSGTGRTAP
>CP034463.1|AZP14737.1|39176_40124_+|IS481-family-transposase
MSKTTPLDREAKRRLAVIRHVEEVTGNVAMSCRYFGISRQAYYIWYRRYQAEGIEGLRTRSKAPKHSPNATHVEVVGKIIYLRQNYHFGPEKIAMYLKRYHDVTISKSGVWRILNRLDMGRLPASQRYKRHDRRWKRYEKKLPGHRVQIDVKFIEPLASMPQGRRGGRNKYFQFTAIDDCTRLRVLRIYPTLNQATAIQFLDYVIQRLPFQVEVIQTDNGAEFQSAFHWHVLDKGIAHTYIKPRTPRLNGKVERSHRIDAEEFYRLLEGVIIDDAEVFNDKLREWEDYYNYHRPHGGLGGQTPYERLKQKTTTQA
>CP034463.1|AZP14738.1|40238_42272_+|NACHT-domain-containing-protein
MAGLGGRRWRRRWQMFGALGALAVVASVAYAMRQLLHGGLEPGDTAGLLGLPLGVIGLVVSVVALRNPVEGNDAERSRGWAATLAKQVEDGESGVWRQLLGDDTRRINLAYDLQPAVSRPAVALAAGRLTADGANSATVPDIVSYYRATQPLRLVITGAAGAGKTVLALELLLALLDGRAEDDPVPVRIPLSRWDTERQLLPDLLRQRLVEAYDWPTDLAAGLVRQHLVLPVLDGLDEMDPLVDGSPDPAAPRATAVVRALNAYQQGRDAGPLILTCRTRHYDALATHAEVLDAARITIAPVDATDARTYLTDRALTTDRWQPLLDHLAAHPSGLLATVLSTPWRLCLTATVYHRDGDPGELRTLLDASTLDDHLLARYIPAATRIAPNPHGYAPKDVHRWLHHLTTHLDPTGALPATAPTSVEATDLLLHELWPLAGRTRVRTTDAVLTTLAVLPSAWTAPLKPTGLAALITALAVMSGALAITTGQPTSTANPLRTRQGRREFAFWLAGGLVLGLAIGLAIWLAIGLAAGPTVGLAAGFATALTVGLTREPGTNLGARAVIRSDAMAGLMFGLTFGLAVGLAGGLEIGLAAGLAAGLAMGLAAGLSAGLAGGARASRRYAVFLLCSRRRLPFRLGLFLDWAVTAGLMRYSGPAYQYRHRELQHWLRQHPQPADLP
>CP034463.1|AZP14739.1|43730_44726_+|ATP-dependent-DNA-ligase
MPASSPGWSLPEPMRAVPVTDPALPAGWAAQLKWDGYRALVGRWADGRVAVRSRNGGDLTASFPEIEEAVRLLPDDTAVDGELVVWEGGRLAFERLQQRMHRRGAAATRAAGELPAHLVAFDLLRLNGQGLTGWPFSDRYAALQELFLKHHLAAPWSLCATTTDPVQAAAWLADYPAVGIEGLVFRPLASRYVPGGRGWTKYKMRHTTEAVVGAVTGSLTAPTTALLGRYDDAGRLRYAGRTTTLSTTARQTLAGQLRTGGADYPWTGRTFSAGWSSREHLSVRLVVPEAVAEVAVDVARDSPGRWRHPVRFTRIRADMTLGDVPLFGAAP
>CP034463.1|AZP14740.1|45405_46089_-|hypothetical-protein
MLLEPPGWPGRPEGLPHWPYVRAVDDALAARGIPPGSVHADCTTREYGGLTTYMWLTWDASRTRYRSSGIRLHWQERRGWFYALTCLNTREILLYAPLAPLRTVVPDPEHVTDVAEQLVRFRQIPDMEYRTEWERGEELRAAARDFRRAVLGLPPLAHPETPTGPGGRPDAEQEQGMRLTIDTLTDTYEQALAAVQAIYGHNEDAPHRRSPTDLGQALRPTMEEHER
>CP034463.1|AZP14741.1|46131_47142_-|hypothetical-protein
MTTSAVTPDQVSTIMHVRCPDGLPEPAYRQLLELMAELSPIVQALPPSAAVVELKGALRYHGTDARRLGEILRIRSLSRLGVDVRVGIGPTITVAATASAQVPSPGGILAVAPGEADDWLGPLPVEALHGIGPRQAAVLRDYGIHCVGLLAAVPPATVHRLLGGRAGRIAADRARGIDPRPVVPRALPPAASVRCRFERHVLDGATVRAALLELVVRLGRQLRRRDQVARALTLTLTFAGNTRWEKTRRLVEPSAHDDDLRTLAYQLMDAAGLQRGRLTGLSLRGEDLIGADQAAEQISLDDAREARLVAETVVDRVRDKFGAGVIGPAAVFRRAS
>CP034463.1|AZP14742.1|47923_49141_+|site-specific-integrase
MWLCGGLLHDSWQEFGMRAFPVVMPSGQRYWTVLDDHLEVVSLADQWLRHLRFGRDRAELTTKAYAGSVALYLRWSGSTGRAWAEAGRDLGLFMVWLKYTPAPRDGVVPVVRAGPGAVPVRGERRINRVLVAVRGLLSYAVSVSEAPRSVLGQIYELADSRDLPAEAQGEDGGLFYRLRPVHSLREPETTVDRAADAALVAMFVACRNARDRLIVLLVGRVGLRRGQVAGLRRSDVHLLPDSRALGCDYPGAHVHVRRRENVNGAWSKSRPAWVAPLDFLVVSAFDLYYDERHRLLGMGGSDFLLVNLFRAPLGEPMSPEAIGELLERLSGRAGLDRRVGAHMARRAFASNVTDAGGQPDEVQAVLGQKSLDSQAPYLFPDPKRVRAAIERVPSPRGMAGPEDSR
>CP034463.1|AZP23008.1|50454_51636_+|hypothetical-protein
MPDEPEDTEAGRDLPDEVLRELCAHLDELEAQSSTEVRVATELLIDTGRRPDEINTLPFNCLEQDPDGSDVLVYDNHKAYRLGRRLPIGAETAAVIRRQQQRVRERFPTTAPARLRLLPRPKSNPEGTKPLVDVSGHHRAWVKSLPDILVPVVAADADTRVTRLVPFDKKRIFPYAYRHCYAQRHADAGVPVDVLKELMDHRLVSTTMGYYRVGDERRREAVDRVTALQFDRHGDRVWRTAKSLLDSEHVRRAIGEVAVPYGVCREPTNVAAGGHACPLRFRCLGCEHFSTDVSYLPDLQAHLADLLRSRERLMSAFEADDWARTQAMPSEEEIRRIRRLIERVQTDLDDLTPEDRAQIEQAVTVVRRSRTVMLGMPRVRQPLPDVRPARTPT
>CP034463.1|AZP23009.1|51644_52157_+|hypothetical-protein
MQDGRHAGTERRRQRVQDAIAAAVRDGTALTASAIAHAARVDRTFLYRHRDLLDNLHTASSRSTSPSPGSAPTVTTASLQADLANANARATRLAARVRHLEEHLSRQLGERAWHESGLSAPADIAELHAAVTHLEQRTVELSRDLEERQAELEAARAANRELTRALNQRG
>CP034463.1|AZP14743.1|52192_53473_-|hypothetical-protein
MDTNILRGFELQSPKAELLRAIKTADVGGVSVPWAALEELAGQRARTYHLAHEKAEAALRALAKSAPTGNSGVVAPLDHDRVLQYWRQRYLEIVDVIPTSANALEQATTREAAVLPPCKAVDIVNEEGKVIKTIKTGGRDTAIWLSAVEYATEHPQETVYFVSENIKDFGRGETYKYPMDRDVEKLGDRFVHLLKLEDILPQFSEEIDVPESDLDSALRGQGNLETIAFETRFGAPLRPSRHQTGWRRFRSTQLEEPTGAELPEGIAEVWLGNPNVSFASVRDAKAYRIGDHVWCTAWVTWLLSGHALLNRTLDIAEVGCAWETRVLVSLTDSTSKLDILRSSTPRAATAQEADNLPEVDPLILPDYIAELDDRIRRNRMSRNMRHYLGQASTAEEALDMMLGFARPSPLPLPTAEVEVWVEPDED
>CP034463.1|AZP14744.1|53837_54920_+|hypothetical-protein
MASHPLGLFPAHDADRHGKGKQKMHGLALYITHVWEAAATTDTSLCRVHGMEVDTERIALEVAPALAAIRTLDRDVICLSQTAAEQTRYLDFQKDDPQGRAVRGLLILRNADTHVPATIEVPADRVVGGVGLGYRVMPRWLSFDDLPDAIRNNPKNNPGAVQAYKDAVGGQLVMDTLLDAFAFIDRCDPTLARRVRGTDDLEYFPLHDYTTHDYDRLHPDQPSRPQLDAEIRRLTQETPPYGTGREILHSFNRDGQEVYCGNTIRHDIRTAFVEPGMQVTRDIRAGFPYSVITSDGTQHDVTVDEEGHLTAAGSPLASVPLQTPRNHCRPEVCEGWWELTTSDAFLYRQQRHLHEAIRDL

Crispr_ID: CP034463_2

• CRISPR_ID: CP034463_2
• CRISPR_location: 310307-310400
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034463_2

Consensus_repeat	Method
TGGGAGGCGGGCGGGAGCCCGTCGGTGGGGGCG	CRISPRCasFinder

spacers of CP034463_2

>2.1|310340|28|CP034463|CRISPRCasFinder
AGTCGGTCGGTGGGGGCGAGTCGGTCGG

CRISPR arrays and Neighbor proteins around CP034463_2

CRISPR arrays

The CRISPR arrays of CP034463_2

>merge|CP034463|2|310307-310400|CRISPRCasFinder
TGGGAGGCGGGCGGGAGCCCGTCGGTGGGGGCGAGTCGGTCGGTGGGGGCGAGTCGGTCGGTGGGAGGCGGGCGGGAGCCCGTCGGTGGGGGCG

>CP034463|2|2|310307-310400|CRISPRCasFinder
TGGGAGGCGGGCGGGAGCCCGTCGGTGGGGGCG	AGTCGGTCGGTGGGGGCGAGTCGGTCGG
TGGGAGGCGGGCGGGAGCCCGTCGGTGGGGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034463.1|AZP14941.1|320522_322868_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|225669
CP034463.1|AZP14936.1|315163_315550_-|ferredoxin-family-protein	unknown	unknown	gnl|CDD|224069
CP034463.1|AZP14924.1|297867_299505_-|AMP-dependent-synthetase	unknown	unknown	gnl|CDD|341277
CP034463.1|AZP14939.1|317237_318596_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224172
CP034463.1|AZP14940.1|319466_320270_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
CP034463.1|AZP23030.1|299501_301214_-|CocE/NonD-family-hydrolase	unknown	unknown	gnl|CDD|273375
CP034463.1|AZP14937.1|315835_316228_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380364
CP034463.1|AZP14938.1|316431_316674_+|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14926.1|303661_304519_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235633
CP034463.1|AZP14928.1|305833_306130_+|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14935.1|314661_315159_+|Ohr-family-peroxiredoxin	unknown	unknown	gnl|CDD|274649
CP034463.1|AZP14930.1|307746_308079_-|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14929.1|306780_307071_-|hypothetical-protein	unknown	unknown	gnl|CDD|237864
CP034463.1|AZP14932.1|310417_312049_-|ubiquinol-cytochrome-c-reductase-cytochrome-b-subunit	unknown	unknown	gnl|CDD|379304
CP034463.1|AZP14934.1|313275_314040_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP034463.1|AZP23031.1|308730_308940_-|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP14927.1|304511_305360_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP034463.1|AZP14925.1|302048_303611_-|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341259
CP034463.1|AZP14931.1|309399_310242_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP034463.1|AZP14933.1|312155_313094_-|dihydrofolate-reductase	unknown	unknown	gnl|CDD|240643

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034463.1|AZP14941.1|320522_322868_+|ABC-transporter-permease	gnl|CDD|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0.000669396
CP034463.1|AZP14936.1|315163_315550_-|ferredoxin-family-protein	gnl|CDD|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	3.7336e-10
CP034463.1|AZP14924.1|297867_299505_-|AMP-dependent-synthetase	gnl|CDD|341277	cd05973, MACS_like_2, Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.	0
CP034463.1|AZP14939.1|317237_318596_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.53153e-98
CP034463.1|AZP14940.1|319466_320270_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.55791e-06
CP034463.1|AZP23030.1|299501_301214_-|CocE/NonD-family-hydrolase	gnl|CDD|273375	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c., putative hydrolase, CocE/NonD family. This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity].	9.15791e-152
CP034463.1|AZP14937.1|315835_316228_+|cupin-domain-containing-protein	gnl|CDD|380364	cd02236, cupin_CV2614-like, Chromobacterium violaceum CV2614 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to CV2614, a Chromobacterium violaceum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.06311e-08
CP034463.1|AZP14926.1|303661_304519_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235633	PRK05872, PRK05872, short chain dehydrogenase; Provisional.	1.06698e-68
CP034463.1|AZP14927.1|304511_305360_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.719e-33
CP034463.1|AZP14931.1|309399_310242_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.84879e-13
CP034463.1|AZP14932.1|310417_312049_-|ubiquinol-cytochrome-c-reductase-cytochrome-b-subunit	gnl|CDD|379304	pfam13631, Cytochrom_B_N_2, Cytochrome b(N-terminal)/b6/petB.	4.29922e-59
CP034463.1|AZP14934.1|313275_314040_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.20545e-10
CP034463.1|AZP14935.1|314661_315159_+|Ohr-family-peroxiredoxin	gnl|CDD|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	2.61997e-48
CP034463.1|AZP14925.1|302048_303611_-|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
CP034463.1|AZP14929.1|306780_307071_-|hypothetical-protein	gnl|CDD|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	2.92814e-07
CP034463.1|AZP14933.1|312155_313094_-|dihydrofolate-reductase	gnl|CDD|240643	cd12166, 2-Hacid_dh_7, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.93184e-131

Protein sequences

>CP034463.1|AZP14931.1|309399_310242_-|alpha/beta-hydrolase
MNRTVRTSRTRTALTALATASVFAGLLATATGSAAADKDPATEAPKPTVVLVHGAFADSTSWNDVIRRLRHDHYPVVAVANPLRSLSGDSAYLRDVLAGIDGPIVLAGHSYGGSVISNAATGNENVKALVYLAAFLPDKGESAADLAGKFPGSTLGDTLRPVPTMNADGSPVNDLYIQNTSFHHQFAADVPRATTDLMAVTQRPITDAALAGASAEPAWKTIPSWVLVATQDLNIPPAAQEFMAERAHAHTSKVRSSHAVSVSKPGKVTEVIENAAHAVR
>CP034463.1|AZP23031.1|308730_308940_-|hypothetical-protein
MPRVGWSVEQRAAVKRYMLFTTIFAVIGVAFSVFLIALGIKGGWVLLGMVVCIYAATRLFVGNVKRNQP
>CP034463.1|AZP14930.1|307746_308079_-|hypothetical-protein
MGINLGEGDGCELPATAVCWLTDDPFPGIILVEFADVYDRPHQLVGKTAYFGGDLQPTSPYPCPTSIQCTIEEIADDVATVSTWWLEGGPNDTRFVFDVWLDTLTPITDA
>CP034463.1|AZP14929.1|306780_307071_-|hypothetical-protein
MPSVPFGGLPYVGWPPLPPLPPAPAPPPWPLKPAPPSPPLPPSPPRPGPPTSPGKEDLPSAPSAPSPPAVPLPPSRESRRSVSMPAVDVQFAPGPW
>CP034463.1|AZP14928.1|305833_306130_+|hypothetical-protein
MRPTPSASMASVDVVPVGALNIERLTSSCPDHTAHLLADRELFAELKSDGARTGATPGVAETAVVEVRSRHGRLASIQQTLGLAAPAAAVQPGGRLSG
>CP034463.1|AZP14927.1|304511_305360_-|alpha/beta-hydrolase
MTTTKSMKWIDVPTRTIDVGGVPFAYRELGPTGGVPVVFLHHLMAVLDDWDPRIIDGIAARHRVITFDNRGVGRSGGSVPPDVEEMGRDAVAFIRAMGLEKVDLFGFSLGGGVAQMVALQAPELVRRIVLAGTGPRGGGGIKEINKVAVKAYVKSALTLKDARTFLFFPRDAEGKRAAKDYLARLKERTQNRDEKISLQARRAQLKAIRAAGLHAPDDLSVITQPVFVANGDHDLMVASSNSADMARRIPNARLRIFPNSGHGGVFQYHREFVPEVLEFLNG
>CP034463.1|AZP14926.1|303661_304519_-|SDR-family-NAD(P)-dependent-oxidoreductase
MAERSDRSIAGKVALVTGGGRGLGAATARALAAAGARVFVVDLHRPAAGETIDERVTHLVGDVTDLGDMTRAVETVIRDAGRLDIVIANAGVVARGVTLRASSAPMADRLLDVNVRGVLNTVRAALPGLIENRGRLVLISSVFAFVNGAGTIPYAMSKAAVEQLGRGLRVELAAHGVSVTTAYFAMINTDMIRQSVDEDPAAQALLDTQPRFLRKRISPEQAAQAIVEGLRRRDVRVFRPRRWTLVSRLRGIVAPALDSALARDRTVQNILQRLDAREGKDFLTT
>CP034463.1|AZP14925.1|302048_303611_-|long-chain-fatty-acid--CoA-ligase
MTSSTRNVSGLLTRTASEHPARTAIVFGGDRISYAELDGASNRVANLLIERGVGPGEKVALSCANIPQFTTIYFGILKAGAVVVPLNVLLKAREIAYHLNDSDATAYFAFEGGPELPIGREAWSAFQTAGRAAHFFLIGSGASVDGVAPDQIFAAAVAGQPETFETVERADDDTAVILYTSGTTGQPKGAELRHRNVYDIARAGAQLFESDPATPDVYLCVLPLFHAFGQMVIQNGAIGFGGTLVLQARFSAHEALELMLDHGVTFFGGVPTMYWGLLEALDDRVDVARLAANLRIAVSGGSALPAKIHQEFRKRFGVTILEGYGLSETVAIASFATYGEEPRVGSIGRPIPGVQMKLINDDWSDVGDDPGAVGEIAIKGYNIMKGYYKRPEATSEAISQGWFRTGDLARKDADGFYFVVDRSKDMIIRGGFNVYPRELEEVLMEHPAVSLVAVIGVPHPSHGEEIKAVVVKKADDSTTEAELTAWGKEQFAGYKYPRIVEFVDALPMTATGKVLKRELS
>CP034463.1|AZP23030.1|299501_301214_-|CocE/NonD-family-hydrolase
MRDGVGLAANVWHPAQGEAPTLLVRLPYGKDVMGFGQSVVPDVLTLVEAGYAVVVQDCRGTHRSEGEFVPHMADRSDGADTVAWIADQPWSDGTVGMYGPSYLGMVQWETAVTGAPALKAIAPAFTSIDNYEAPWYGPGGALSLSLVTMWNAMMYAADAQRSLAAGEGGSLSQVQQLSQAVLTHEALNDVLPTAEVPVLATYGKWWDDWMAHPSHDAYWDAMELTPELKNVTVPALNIGGWYDLYIGQTVRTYTTARQKAGSAQAREGQRLIIGPWDHLSASGVYPDRSFGPLASAQMMGLTGLHVKFFDRWLRGDTAALDDVAPVKIFVMGIDQWRDEQDWPLPDTRWTDFHLTSTGRANTAAGDGVLTTEAPTDAGHETYLYDPRRPVPTAGGASMPVTLELCGPVDQQTVAAREDVLCFAGPVLEKPVEVTGPVSLTLFVSSSAVDTDFTAKLVDVFPDGKAINLCDGILRTRYRGGLATEEPMEPGTVYEITIDMTATSNVFLPGHRIRVDVSSSNFPRYDRNTNTGGVIAREGEEQMIPAVNHIHHGPNHPSRLVLPVIDREDQS
>CP034463.1|AZP14924.1|297867_299505_-|AMP-dependent-synthetase
MSAAGRVAELTATFTAPSLNVAELLCDRHPADRTAFTLVDGDGKASTLTYGELAANSHRCARALQELGVGPGDRVATLMGKGTNLVTVVLAIWRLGAVYVPLFTAFAPQAIALRLEGAGAHVVVVDPDQRHKLDPGPDMPDDPQRRIIVTGAVTSGGDRSLADLVAAASPEPVPAVITSGDGPLVHMFTSGTTGKPKGVIHPVSYIAGWQIYLEYGLGVTPASSYWCAADPGWAYGLYAAIVAPMAAGLPSLLLTGGFSAETTWRTLLDHQVTDFTAAPTVYRGLRSSSVAVPEGLCLERASSAGEPLTPEVNEWAGAALGLAVHDHFGQTEVGMPLANHHHPELARPLKTGSMGRPVPGWSLTVLADEKDEPAGAGVLGRVAIDVAASPLMTFRGYQIAGQSASKFTPDGRYYLTGDAARIDADGDFFFSSRDDDVIIMAGYRIGPFEIESVLAQHPSVADCSVIGAPDEVRGEVIEAYVVLRDGGEGSPELATELQQLVKTRYAAHAHPRTIHFIDALPKTPSGKTQRYLLRKRRRAELTTPE
>CP034463.1|AZP14932.1|310417_312049_-|ubiquinol-cytochrome-c-reductase-cytochrome-b-subunit
MGNDSRPAGPQRERGGERLATWVASRTGLRATARSARRLVFPDHWSFMLGEIALYSFVVLLITGVYLSLYFHPSTDLVVYQGGYAPLRGQLVSRAFDSTLHLSFDVRGGLLIRQAHHWAALVFVAAVFAHLLRVFFTGAFRKPRELNWVLGFLLLVLAMFAGLTGYDLPDDLLSGTGLQVVNGTLLSIPVVGTYLSFFLFGGEFPGEDLIARFNTLHTLVIPALMIAVLVGYAVLALRHRPTQYPGPGRSENNVVGLPFAVRAVKSAGYFCFVSGVIFFMAAVAQINPVWNYGPFRPDQVSAGSQPDWYMGVADGLLRVMPGWEIDLWGHTLALDNLLPLLAGLVLFLAMGAYPFLEAWVTDDDRDHHLLDRPRNRPVRTALGVAWLSVYAVALVGAANDVIAIWLHVSVNSVTWAVRVGLFVAPVLAFVITKRLALGLQRRDRDMVLHGRETGVIKRLPHGEYVEVHEPLDPARLHTLTAHEQYRPLELAPDPDPDEPAPTWTRSATRHLRVALSRALYGPGTQIPKPSPPEHEELTARHRP
>CP034463.1|AZP14933.1|312155_313094_-|dihydrofolate-reductase
MTVRSPQVWLPAQFGRLADLPPGLDYARWDGRSAFPTDPAEVEFYVPPLTKDIGVIARPLARMTRLRAVQALSAGTDELRAVLDRLPRDVTLCNAKGVAAADTAELALTLILASLRGIPESLRAQDREDWDPRTFSTLRERSVLIVGHGAVGSALEELLTPFGCAVTRVGRADRDTPQGPVRSVSLLPGLVPDADVIVLCTPLTGATRGLFDAALLSRVKDGALLVNVSRGAVVDTDALLKEVDGGRLRAALDVTDPEPLPPGHPLWTAPGVLVTPHVGAFTPDFWPRLEALVRRQLARFAAGRELENVVTR
>CP034463.1|AZP14934.1|313275_314040_+|class-I-SAM-dependent-methyltransferase
MHTILSGPSGLRPEHDSYAVTAEFYDILQADEDEARVRRLYSRQIADARTGVLDVGAGTGRVTMLALADSGADVHAVEPARAMRTSLLTRLAALSCEQRDRVTVHPHPLDETALDAVADVAVCHNMVGCLPPGIREKLWPALGRALTPGGSLFVQLPPARLPARTVVRRLADKRVGEHIYGGRMTMSAAGYRIRTRADYWVRDAEDVLREHTETFWMWPATRARLTDELAAHGFAPLPGYEESELLAVTLNVRR
>CP034463.1|AZP14935.1|314661_315159_+|Ohr-family-peroxiredoxin
MTDPIQLPDLSTGKDFTGDTFSPLYTTTVTVDGGAVAHGRASGRARSSDGALDLELRMPAELGGPGTGTNPEQLFAAGFAACFHGALSLLARQEALDPAAVSVLATVAFGRDPEDGGYLLHVDLVVRWPGVPRETATRLMKRADALCPYARMAWRGTPTTITLAP
>CP034463.1|AZP14936.1|315163_315550_-|ferredoxin-family-protein
MTYVIAQPCVDIKDRACLAECPVDCIYEGVRTLYIHPYECVDCHACEPVCPVEAIFPEDELPRHWAHYRAVNEEFFEAGSAQRRGPRPAQGDHPVVAALPPQHVRKKEIAGFAVRGEEAADVDPWFPL
>CP034463.1|AZP14937.1|315835_316228_+|cupin-domain-containing-protein
MGLSLAPTTAQATPGGPGGSGRVLAQRTVGDTDYILREITIPPGQATGWHYHDGTLYAFVKQGTLSHFDASCTFDGVYEKGSFLKEPSGADHVHIGENPGATDIVLEVLHVLPHGAPFSQEAPSPGCELP
>CP034463.1|AZP14938.1|316431_316674_+|hypothetical-protein
MTRDADRPTDPAAVTVSLAAEAAVLEGRLGVILEAIDEVDARIRAVSEKISRLPAAGDHVASPVNEAHATGLTPSPTRRL
>CP034463.1|AZP14939.1|317237_318596_-|NAD(P)/FAD-dependent-oxidoreductase
MREILIVGGGYAGFCTAWGLEKRLRPGEARVTVVDPRPYMTYQPFLPEVVAGSVEARHAAVSLRRHLRRTRLVAGSVTEIRHSARTVTVRPESGPSLDLHYDVLVVTAGAVTRTFPIPGLSDQAYGLKHVEEAVAIRDRLLTSFDRAAGLPRGPERSKLLTVTVVGGGFSGVEGFGELLALATALLKQYPEIGADEPAFHLVEARDRILPEVTDRPGAWVVRSLEKRGARVHLNTQLVSAEDGRVRLSDGTEYDSGLLVWTAGNAANPIVHNHSDLPVDERGLLTVRADLRVTTDTEVVPDVWAAGDDASVPDLAAGRPGAHTVPNAQHAVRQGKRLAKNILASLRGRPAKDYVHRSLGVVATLGLGRGIFQYRGLVIKGFPAWLMHRGYHVLAIPSWERKTRVFAVWATALLYGRDIVSLASVQHPREAFVSRGEPRRGEEPAQPGDRLTA
>CP034463.1|AZP14940.1|319466_320270_+|TetR/AcrR-family-transcriptional-regulator
MAQQVVTRRVADTGKNPTSEREDVLAAAAGCRARTSGNTQATAAPGCGAVGARPRRGAARRRGTQSPTHPAAARRLLSREGLGVPMTAIAREAGVGNTTLFRRFGMREQLIDAAFTDRVETHHSLVAACSDDPDTWQGFADYVRGLSALRAADPTFVEVLTMTFPGGVVETRRAEAARGALRTISRAREAGYLRQNFDDRDLTLILPANSGTLRASGATAPKASHRLVAQLLRAYATADAPVEPVPEAPQRTELYHTMIGVIRSRTA
>CP034463.1|AZP14941.1|320522_322868_+|ABC-transporter-permease
MVSPPVRRRLGGLRALAFGARLALFGGRNSAIRTSLTAVGVGLGVAMLLFAASVPTVRNHRDQRIHQRIDVNLSDRAITRSDHTVLVRDIDTVFRGEKIRGRMVQPEGPAAPLPPGVLRYPRPGEMVVSPALHKLLNAPGNGLLRERLAHPIAGEIGDAGLLAPGEHVFYLVANHMAPDAGPTRRLDHFGKTYPRKPLPPELLLLCIAGIVVLLVPVGAFIAAAVRFGGERRDRRLAALRLVGANRGMTATIAAGEVALSTLAGTALGVVLFMTGRQFAGTVELQGLGVFPQDLTPQPLLAALVVVAVLSLSLGITQLSMHKVAVEPLGVVRKSGSTSRRLWWRIALPLLGLILLRLSVRSPADLHGTSGVVLLLIGMLSLLVGVTAVLPWAVERLTRLLGGFGPLPWQLAVRGLQLNGEATSRSVNGIAVAVAGAVALQTLLTGLAHNPVDSTARGAYGPSASTRVAVARLDDGGTRGAAYAPVLATTPGVQRAVEFRELSMSPLNGGFPQTVLIADCAHLRLLAQLPSCSDGDAFLTAPPGTDTRHDLTTWAAGMKLRMDMYGPRWTVPHIAATVRATPAYPAAVSSERTLLATPEAAGHTAIAHAVSTVGLTYATGFEDVEDHIRTAAARLDPAFSVEFPGKSQGNPALDGVRRALLAGVTAVLVLIAASMLLGALEQVRERARVLSVLVAFGTPRRTLATSVFLQSVLPVGLGLLVAESIGTALGSSLLDLVGIPAPRNWSTLLAIAGIGATVSLGVTLLTLPALWRSTRPQGLRHE

Crispr_ID: CP034463_3

• CRISPR_ID: CP034463_3
• CRISPR_location: 2950489-2950594
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034463_3

Consensus_repeat	Method
GTCGCAGATTCCGCTCATCTCATGTC	CRISPRCasFinder

spacers of CP034463_3

>3.1|2950515|54|CP034463|CRISPRCasFinder
CCCTGTCGGCAGTGGTCGCAGATTCCGCTCATCTCACGTCTCCTGTCGGCAGTG

CRISPR arrays and Neighbor proteins around CP034463_3

CRISPR arrays

The CRISPR arrays of CP034463_3

>merge|CP034463|3|2950489-2950594|CRISPRCasFinder
GTCGCAGATTCCGCTCATCTCATGTCCCCTGTCGGCAGTGGTCGCAGATTCCGCTCATCTCACGTCTCCTGTCGGCAGTGGTCGCAGATTCCGCTCATCTCACGTC

>CP034463|3|3|2950489-2950594|CRISPRCasFinder
GTCGCAGATTCCGCTCATCTCATGTC	CCCTGTCGGCAGTGGTCGCAGATTCCGCTCATCTCACGTCTCCTGTCGGCAGTG
GTCGCAGATTCCGCTCATCTCACGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034463.1|AZP17054.1|2940087_2942604_-|aminopeptidase-N	unknown	unknown	gnl|CDD|274121
CP034463.1|AZP17068.1|2956559_2957345_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|236110
CP034463.1|AZP17055.1|2942651_2943203_-|response-regulator	unknown	unknown	gnl|CDD|381093
CP034463.1|AZP23225.1|2943707_2944583_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
CP034463.1|AZP23226.1|2952156_2952963_+|CoA-transferase-subunit-A	unknown	unknown	gnl|CDD|224702
CP034463.1|AZP17059.1|2947498_2948944_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
CP034463.1|AZP17060.1|2949060_2949591_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
CP034463.1|AZP17056.1|2943345_2943696_-|chorismate-mutase	unknown	unknown	gnl|CDD|181719
CP034463.1|AZP17069.1|2957405_2958545_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173841
CP034463.1|AZP17070.1|2958544_2959489_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|224871
CP034463.1|AZP17067.1|2955923_2956544_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380061
CP034463.1|AZP17066.1|2954729_2955887_-|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|181123
CP034463.1|AZP17057.1|2944790_2946524_+|beta-galactosidase	unknown	unknown	gnl|CDD|366567
CP034463.1|AZP17063.1|2951382_2952141_+|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl|CDD|181174
CP034463.1|AZP17053.1|2938568_2939975_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|99743
CP034463.1|AZP17065.1|2953675_2954725_+|nitronate-monooxygenase	unknown	unknown	gnl|CDD|240081
CP034463.1|AZP17058.1|2946569_2947451_+|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP17071.1|2959463_2961113_-|cytochrome-bc-complex-cytochrome-b-subunit	unknown	unknown	gnl|CDD|379304
CP034463.1|AZP17064.1|2952959_2953676_+|CoA-transferase	unknown	unknown	gnl|CDD|224968
CP034463.1|AZP17052.1|2937147_2938572_-|lysine-6-monooxygenase	unknown	unknown	gnl|CDD|226017

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034463.1|AZP17054.1|2940087_2942604_-|aminopeptidase-N	gnl|CDD|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
CP034463.1|AZP17068.1|2956559_2957345_-|SDR-family-oxidoreductase	gnl|CDD|236110	PRK07831, PRK07831, SDR family oxidoreductase.	9.61924e-160
CP034463.1|AZP17055.1|2942651_2943203_-|response-regulator	gnl|CDD|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	9.22689e-25
CP034463.1|AZP23225.1|2943707_2944583_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.37664e-24
CP034463.1|AZP23226.1|2952156_2952963_+|CoA-transferase-subunit-A	gnl|CDD|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	5.5241e-58
CP034463.1|AZP17059.1|2947498_2948944_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.95537e-57
CP034463.1|AZP17056.1|2943345_2943696_-|chorismate-mutase	gnl|CDD|181719	PRK09239, PRK09239, chorismate mutase; Provisional.	5.10189e-56
CP034463.1|AZP17069.1|2957405_2958545_+|acyl-CoA-dehydrogenase	gnl|CDD|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.63269e-126
CP034463.1|AZP17070.1|2958544_2959489_+|acyl-CoA-dehydrogenase	gnl|CDD|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.0645e-29
CP034463.1|AZP17067.1|2955923_2956544_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	2.3237e-17
CP034463.1|AZP17066.1|2954729_2955887_-|acetyl-CoA-C-acetyltransferase	gnl|CDD|181123	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase.	0
CP034463.1|AZP17057.1|2944790_2946524_+|beta-galactosidase	gnl|CDD|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	4.41909e-133
CP034463.1|AZP17063.1|2951382_2952141_+|enoyl-CoA-hydratase-family-protein	gnl|CDD|181174	PRK07938, PRK07938, enoyl-CoA hydratase family protein.	5.68714e-149
CP034463.1|AZP17053.1|2938568_2939975_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	1.78353e-72
CP034463.1|AZP17065.1|2953675_2954725_+|nitronate-monooxygenase	gnl|CDD|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	5.0937e-85
CP034463.1|AZP17060.1|2949060_2949591_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	9.09394e-18
CP034463.1|AZP17071.1|2959463_2961113_-|cytochrome-bc-complex-cytochrome-b-subunit	gnl|CDD|379304	pfam13631, Cytochrom_B_N_2, Cytochrome b(N-terminal)/b6/petB.	1.1808e-62
CP034463.1|AZP17064.1|2952959_2953676_+|CoA-transferase	gnl|CDD|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	2.56025e-33
CP034463.1|AZP17052.1|2937147_2938572_-|lysine-6-monooxygenase	gnl|CDD|226017	COG3486, IucD, Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	1.95587e-157

Protein sequences

>CP034463.1|AZP17060.1|2949060_2949591_+|MarR-family-transcriptional-regulator
MSSDTASGPTSNGPVPNLERAVPRDDKRRADTLLRLFTAGRENSGATVMFHAAVAARQGLNPTETKALDFLERHGPLTAKELAELTRLAPASVTGLVDRLEAKGIVRRVKHPTDKRRVLVELNREKLAELFGFFEDYAVEIAKKCEGFTTEELETVIRFLDVMTEHQREAAERLAE
>CP034463.1|AZP17059.1|2947498_2948944_-|MFS-transporter
MTTTGLTTTPPATAEPPYPRRWAAATVMMIAALMDLLDVTIVNVAIPSIGRDLHATPTDLQWLISAYLLGFAATLIVSGHLGDRFGRRGLFLAGTAGFGLASLGCGIAQTPGQLIAARAVQGVMAAVLMPQVLGSFRTLFHGKERGAAFGMYGAVAGFASAVGLLLGGLLTDADLFGLGWRSVFLVNVPIAIATLGAGLLLVPSTKERSAGRPDVLGSVVLAGGLVAIALPLVQGRENGWPLWGWSCLAAGVCAIVGLAVFEARRRRPGTTPLLPGRAFRSPAFSVGVVVQLVCSVGMQGFFLVFIVWLQGGQGYSPLQAGVVAVAYSAGAFLTAPVADTLATKYGRWVLGAGALLMAGGFAWVWAAVTGAADTHTGAWPLVPGLVVAGAGLGFLVVPLVNVVLSAVPGELAGGASGILSTAQQFGGALGAAIIGTVFFAHADDGLTHALTTAMPWVTGGFVACGLLCAALPRRAVSGYEG
>CP034463.1|AZP17058.1|2946569_2947451_+|hypothetical-protein
MANDGPVEHGYPHLETVRAAITALWKRLSYDTVQTFATSVVPADVAFCDTDDLHLGAQRVAREMVRHYRLPDARMIVGFREMTHAANVELAAGPEYFVELNDRFRTHRRDIGAALAHEVMHVYLHRLGLSFPGTRDNEILTDTAATYLGAGWLLLDAYREDSASSQKLGYLTPEEFGYVLAKRSLVFGEDPSVWFTSPQAYTAYVKGMARAREDEQQPPLTAAGWAGRRRYARERKHAAAAPAGVPYAFSPDGGGQLRVSFPCPTCHQKIRVPVRGRMRARCGVCRTVWECDT
>CP034463.1|AZP17057.1|2944790_2946524_+|beta-galactosidase
MSEFTVGDEEFLLDGRPVRLLSGALHYFRVHEAQWGHRLAMLRAMGLNCVETYVPWNLHEPRPGRYEDVAALGRFLDAARAAGLWAIVRPGPYICAEWENGGLPHWLAGRARTSDAVYLRQVERWFGRLLPEVVSRQVDRGGPVLMVQVENEYGSYGSDAEYLRWLASTIRAAGVTVPLFTSDGPEDHMLTGGSLPGMLATVNFGSQAREAFATLRRHRAEGPLMCMEFWCGWFDHWGAGHVVRDPADAAAALREILECGASVNLYMAHGGTSFAGWAGANRGGGDLHDGVLEPDVTSYDYDAPIDEFGHPTEKFWRFREVLAPYADGPLPELPPLPTQLAAGAEVELAGWAPLADVLEARGGPVVTSPVPPSFEALDVDRGLVRYEVTVPGPRQPYPFLARGLRDLAVVYVDGERAGVLTEADERLEEPVAGHARVELWVESLGRVNYGPRTGESKGITGGLLHERQYLHGVRARGLRLDALDAVDDVRLRALPEDGAPGLYRGTLDVNGAGDALLELPGWTRGFVWINGFSLGRYWCVGPQRSLYVPGPVLRDGVNDVWVLELERAASAPYVRSR
>CP034463.1|AZP23225.1|2943707_2944583_-|AraC-family-transcriptional-regulator
MRFFTPGPAHHRLGLVCLGVGLQYGALPTVGPRVLDHHVAVVISTGHGWYAHPDGRRTTITAPALLWLTPGTPHHYAPDPGTGWDEGFVDFTGPATASYTDLGYIEPDRPVVPLSDAAAPRAVIGRMARAARRDNPLLEVETGAAVHELLVALRRARADLTPDGEQLLKALARDACLPLSVADHAARHGMTLAELRTAVRRGAGCSPKDYLLGIRLGRAKELLATTELPVAAVARRVGYDDPAYFSRLFTRRVGTPPVRFRAQQGRVVPGGWSDRVPDPEDPPIIPGTWAP
>CP034463.1|AZP17056.1|2943345_2943696_-|chorismate-mutase
MTTSNPGTGAVDPAVREELARLRDSIDNIDAAVVHMLAERFKATQQVGLLKARHQLPPADPAREARQIERLRSLAENAKLDPAFAEKFLNFIIAEVIRHHERIAENATNGTTPTAN
>CP034463.1|AZP17055.1|2942651_2943203_-|response-regulator
MPSDAKILIVDDHEDTLYALESALAPLGYRLGRATSGDEALKQVLRGQVGLLLLDVRMPGVSGLDVVRYMRRVEQTQHIPVVLLTGFGPDQELTATAFALGVADLVMKPIDPWTLRTKVRYLYDTHRRRLALEEENRALRALVKDGPEAPGRPARPALPHPDPRVPVQRAQGAHTDSLEQDRT
>CP034463.1|AZP17054.1|2940087_2942604_-|aminopeptidase-N
MSCMSVLTRDEAQTRATLLDVHRYTIDLDLTTGDDTFDSKTVIRFTARTDADTFIEVKPAELRSVTLDGQPLDPETLDGNRLPLKNLTAGEHELSVDASMRYSRTGEGMHRFTDPTDGETYLYSNLCMDDAQRVFPVFDQPDLKAVFEITATVPENWTFLANGITTALGDGRWQAAPTPLISTYLVAVAAGPWHSVRTEHRGLPFGIHCRRSLAPHLDADADELLTITKQCYDRYHEKFEEPYPFDSYDQAFVPEFNAGAMENPGLVTFRDEFVYRSAVTDTERQTRAMVIAHEMAHMWFGDLVTLRWWDDIWLNESFAEYMGYQTLTEATRFTDTWTDFGVVRKAWGYDADQRPSTHPVAPDPELVPDTASAMLNFDGISYAKGASALRQLVTWLGEKDFLAGINTHFARHKFANATLADFIDSLASVTDRDVHAWADTWLRTTGVDTLKPVIIPGDEGTYALQVEHDGSRPHRIAVGLYDRALADNAADEGRHLVLRERLDLDVPQPDGPLPIGKRPALLLLNDGDLTYAKVRFDAESFKTVTESLSGLPSPLTRAVVWNALRDAVRDGELPPVAYLEAARAHLPYETDLALVQGVLAFASVQVADRYATPEERPAALATLSSLCRDLIRRTEDGDNPGLRLIAVRHFIDVAAHPDTIAAWLADGTVPGGPELDPELRWRVLARLAVLGATDETAIAAELARDPSATGQEGATRCRAALPDADTKAKAWEAMFTHDDLSNYLFIANAQGFWQPEQADLVRAYVPRFFEDAVTLAARRGPAIADATGRWAFPAHAVDAETLGWGERCLSDADPIPALRRKLADQLDDLGRALRVRQA
>CP034463.1|AZP17053.1|2938568_2939975_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPTPPLASGPDALRPLLTEVLEALGEGARARGGPLPGGGPEAVAERLRAAVGDVLPQEGDPEALRHVVRALAEGSADPADPLCAAHLHCPPLAVAAAADLAASVLNPSLDSWDQAPAASELELLVTRALTNEVYGEPPRGAGNCATSLHLPAADSDALVTTGGTESNQLALLLARESLGAGVRLICGANAHHSLPRAAWLFGLPDPVIVPTPTGTLDPTALAETLTRHQGPHLVAATAGTTDAGLIDPLPEIAAVCDTHGARFHIDAAYGGGLLFSETRRHQLTGISAAGTVTLDLHKLGWQPVAAGLLAVKAPQDLAALHQRADYLNADDDTEAGLPDLLGRSLRTSRRPDVLKIAVTLKTLGRAGLGALVDQVCDRAREFAELLDAHPRFELYDRPTISTVLFRPAHATDDDIAATRRHLLTTGRAVLGRARMDGRLWLKATLLNPHTRPDDLAALLKLVEGTTPR
>CP034463.1|AZP17052.1|2937147_2938572_-|lysine-6-monooxygenase
MSPTPTPTPPHEPDAPRDLVGIGIGPFNLSLAALAHPLAELDTAFYEQRPAFDWHPGLLIDGARIQVPFLADLVTLADPASPWTFLNYLKARERLFPFYFAERFHIQRAEYDAYCRWVAENLPGLHFGHQVDAVRWNPERDIFEVDFTQLDTEGEAEALGRTYTRNIVLGVGTEPYVPEPLKPLVEAAGVPVIHAADYLAHRETLTAAEHVTVIGLGQSGAEIFLDLLRQRPAGREGLHWLGRTEAFAPMEYSKLGLEHFTPDYTRYFHALAEGVRDRLVTTQWQLHKGIDNDTIAAIHDELYQRTLHGGWPDTTLTPGVRVRTAGRVATTKVELHLEHTEQNTRSRLTTDAVVLATGYRERPLARILAGLDPYLRRDSRDRPRVDEHFRLVMDASVTGSLYVQNAERHTHGVGTPDLGLAAWRSAAILNTVTGKDPYPLPTRTAFTTFGLEQTARVPQARQAPAALTPLTDAR
>CP034463.1|AZP17063.1|2951382_2952141_+|enoyl-CoA-hydratase-family-protein
MGVSTSSEEKGIRGDGICVVTVDFPPVNALPVDGWYALADAVRAAGRDPGTRCVVLAAEGRGFNAGVDIKELQARGADALVGVNRGCFEAFSAVYECEVPVVAAVQGFCLGGGIGLVGNADVIVASEDATFGLPELDRGALGAATHLARLVPQHLMRALYFTSGTVTAAELHAHGSVWAVVPREELLDAALGLARKIAAKDGELLRLAKAAINGIDPVDVRRSYRFEQGFTFEASVSGVADRVRSRFGKGDS
>CP034463.1|AZP23226.1|2952156_2952963_+|CoA-transferase-subunit-A
MTDKTMTADEAVSRLQSGMTLGIGGWGSRRKPMELVRALLRTGITDLTVVSYGGPDVGMLAAAGRLRALVAPFVTLDSIPLEPHYRAARESGAFALTEIDEAMFMWGLHAAANRLPFLPVRAGLGSDVMRVNPGLRTVTSPYDDGETFVAVPALRLDAALVHVNRADRQGNGQYLGPDPYFDDLFCEAADAAYVSCERVVGTAEFAKEGPPQSLLLKRHVVTGVVEAPGGAHFTSCAPDYGRDEDAQRAYATTPWPEFAAKYLDGRTT
>CP034463.1|AZP17064.1|2952959_2953676_+|CoA-transferase
MTATRAEYCVIACAEAWRDAGEILASPMGLIPSVGARLARLTFAPDLLLTDGEAMIVDAEGTVEGWLPYRQHLALVTGGRRHVMMGASQIDRYGNQNISCIGDWERPRRQLLGVRGAPVNTLNNPTSYWVPKHSRRVFVEKVDMVCGVGYDHAAGARHHRIPRVVSDLGVFDFATPDHSMRLASLHPGVSVEQVTEATGFPLSLPSEVPYTREPTAQELKLIREVLDPAGARAREVAV
>CP034463.1|AZP17065.1|2953675_2954725_+|nitronate-monooxygenase
MDTALTRLVGVRHPIVQTGMGWVAGPRLVSATANAGALGILASATMTLDQLRDAIREVKSRTDAPFGVNLRADAADAGERVSIMLDEGVRVASFALAPSPDLIARLKAADVVVVPSVGARRHAEKVAAWGADAVIVQGGEGGGHTGDVATTVLLPQVVDAVGIPVVAAGGFFDGRGLVAALAYGAAGVAMGTRFLLTSDSTVPDAVKRRYLAAGVKDVTVTRAVDGLPHRMLRTDLVNSLERSGRPRRLLHAVRRAAGYRALSGLTWRRMLRDGLAMKHGKELTWSQVLLAANTPMLLKSAMVDGRTDLGVMASGQVAGVIDDLPSCAELVERVMKEAEEVISGLPATP
>CP034463.1|AZP17066.1|2954729_2955887_-|acetyl-CoA-C-acetyltransferase
MGEAYIVEAVRTPVGRRKGGLSAVHPADLGAHVLKELVARAGVDPAAVEDVVFGCLDAVGPQAGDIARTAWLAAGLPEEVPGVTVDRQCGSSQQAVHFAAQGVLSGTQDLVVAGGVQNMSMIPIAFATRQAAEPLGLTQGPFAGSEGWQARYAGKPVNQFVGAEMIAAKWGISRQDQEEFALRSHQRALRAIDEGRFARETVAYGDVDVDEGPRRDTSLEKMAALKPVVEGGTITAACSSQVSDGAAAMLLASERAVREHGLRPRARVHHLSVRGEDPIRMLTAPIPATAHALKKTGLSIDAIDLVEINEAFAPVVLAWLKETGADPEKVNVNGGAIALGHPLGATGVKLMTTLLHELERTGGRFGLQTMCEGGGQANVTIIERL
>CP034463.1|AZP17067.1|2955923_2956544_-|TetR/AcrR-family-transcriptional-regulator
MPTKKKPQVTAAPARRRELLDTAAEVFAEQGYNATTVRKIADHAGMLAGSLYYHFDSKESMLEEILRTFLDELWAGYDTVLAAESGPRETLEALVTESFREIDRHRAAVAIYQKESKQLVAQERFGFLVESQRRFEKAWLSTLERGVAAQVFRADLDMRLTYRFVRDTVWVAASWYRPGGQHSPEEIARQYLSMVLDGIAVREQPQ
>CP034463.1|AZP17068.1|2956559_2957345_-|SDR-family-oxidoreductase
MTGVESPVYEPGHGLLKGRTAVITAAAGAGIGGATARRFLEEGARVVVSDAHVRRLKECETELAREFPGAVTAVPCDVTDGTQVTALFEAAVREHGRLDVVVNNAGLGGTSDLVDMSDEQWSRVLDVTLNGTFRCTRAALRLMRETRGGVIVNNSSVVGWRAQAGQAHYAAAKAGVMALTRCAAIEAAGFGVRVNAVAPSLAMHPHLVKVTSADLLEELTAREAFGRYAEPWEVANVIVFLASGYSSYLTGEVVAVSSQHP
>CP034463.1|AZP17069.1|2957405_2958545_+|acyl-CoA-dehydrogenase
MDLAFTPGEQAFREEARAWLAAHVPTASLPSLETAEGFAAHRAWEAELAADRWSVVDWPVAYGGRDAGLVRWLLFEEEYWAAGAPGRVGQNGISLLAPTLFDHGTEEQRARVLPPMARGEVVWAQAWSEPEAGSDLASLRSKAVRTDGGWLLSGQKTWSSRAAFADRAFGLFRSDPDAAKPHQGLTYLMFDLRAPGVTVRPIARLDGKPAFAELFLDEVFVPDADVIGEPGQGWRIAMAATGNERGLTLRSPGRYRAAADRLHALWRDRGGPDGMRTRVADALIGARAYQVFTYAAASRFLDGASLGPESSLNKVFWSEYDIALTETALDLLGAEGELADTEWAERYVFALAGPIYAGTNEIQRDIIAERLLGLPKGRR
>CP034463.1|AZP17070.1|2958544_2959489_+|acyl-CoA-dehydrogenase
MRLVLDDEQRAFTDSLESMLTGADTPSVVREWSRGEHGSGRALWSRLAAAGVFALAAPEEYDGVGVRPVELALAFTALGRHVVPGPLVETIAAAVLLPTPDLVKRLVSGETLATVAYGGPYALDGDAADLCLVLTPDGLHAATGHGPVRPSLDPARRLTTLTPGALLTSEPPLAKALLLARLTTAAQALGVGLALLDQTVRYVRQRTQFGVPVGSFQAVKHQLAAAKTALEFARPLVLAAAVTLDPADVAAAKVTAGEAAYATARTALQLHGAIGYTAEYDLSLWLTKARTLRTAWGSPEECRDTVLSAGDPHC
>CP034463.1|AZP17071.1|2959463_2961113_-|cytochrome-bc-complex-cytochrome-b-subunit
MDGARSVNGRAGGRSSGPPGGGEKLADWADGRLGLYGLAKANMRKLFPDHPSFMLGEICLYSFIVIILTGIYLTLFFEPSGVEVVYNGSYEPLNGIVMTRAFESTLDISFDVRGGLLIRQIHHWAALVFVTGMLVHMMRVFFTGAFRKPREVNWVFGWTLLMLGIITGLTGYSLPDDLLSGTGIRFAQGAILSVPIVGTYLSFFLFGGEFPGHDIIPRLFPIHVLLLPGIMLGLVTAHLILVFYHKHTQFPGPGRDEKTVVGMPLLPVYTAKAGGFFFLVFGMLAFMGGIAQINPVWAFGPYRPDLVTTGAQPDWYLGFSEGLIRVMPGWEINAWGHTLQLGVFIPFSLFPLILAAIGAYPFIEAWITGDKREHHILDRPRNVPVRTGLGVAWLSLYAVLLIGGGNDVVATHLHLSINAITWFVRIAVFVVPVLAFVVTKRVCLGLQRRDRDKVLHGRESGIIRRLPHGEYVEVHEPLAQAQLHTLTQHEQNGHYEIGPLVDANGVRRPVSTSMRVRARLARAMFGPETRIPKPTVEEYRQISSGDHQH

Crispr_ID: CP034463_7

• CRISPR_ID: CP034463_7
• CRISPR_location: 10354886-10354976
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034463_7

Consensus_repeat	Method
CGAGCAACCCCCGCGGGCGCGGGGACGACA	CRISPRCasFinder

spacers of CP034463_7

>7.1|10354916|31|CP034463|CRISPRCasFinder
GGGCGGGGTGGCTCCGGCCCCCGAGGACTGC

CRISPR arrays and Neighbor proteins around CP034463_7

CRISPR arrays

The CRISPR arrays of CP034463_7

>merge|CP034463|7|10354886-10354976|CRISPRCasFinder
CGAGCAACCCCCGCGGGCGCGGGGACGACAGGGCGGGGTGGCTCCGGCCCCCGAGGACTGCCCGAGCAACCCCGCGGGCGCGGGGACGACA

>CP034463|7|6|10354886-10354976|CRISPRCasFinder
CGAGCAACCCCCGCGGGCGCGGGGACGACA	GGGCGGGGTGGCTCCGGCCCCCGAGGACTGC
CCGAGCAACCCCGCGGGCGCGGGGACGACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034463.1|AZP22963.1|10346845_10347856_+|hypothetical-protein	unknown	unknown	gnl|CDD|176459
CP034463.1|AZP22967.1|10353863_10354811_-|IS481-family-transposase	unknown	unknown	gnl|CDD|366234
CP034463.1|AZP22965.1|10349261_10350257_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|185714
CP034463.1|AZP23787.1|10357215_10358388_+|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	unknown	unknown	gnl|CDD|234825
CP034463.1|AZP22968.1|10358406_10358826_-|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|319971
CP034463.1|AZP22966.1|10351715_10353749_-|NACHT-domain-containing-protein	unknown	unknown	gnl|CDD|227922
CP034463.1|AZP22961.1|10340514_10341795_+|hypothetical-protein	unknown	unknown	gnl|CDD|374474
CP034463.1|AZP22964.1|10347898_10348582_+|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP23788.1|10359952_10360948_-|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|237195
CP034463.1|AZP22960.1|10339067_10340150_-|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP22962.1|10344846_10346064_-|site-specific-integrase	unknown	unknown	gnl|CDD|271175
CP034463.1|AZP22969.1|10358822_10359953_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl|CDD|99740
CP034463.1|AZP22975.1|10366374_10367130_-|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP22970.1|10360962_10361979_-|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl|CDD|187557
CP034463.1|AZP22971.1|10362360_10362924_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
CP034463.1|AZP22973.1|10364405_10364936_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379326
CP034463.1|AZP23785.1|10341830_10342343_-|hypothetical-protein	unknown	unknown	gnl|CDD|274008
CP034463.1|AZP22974.1|10364849_10365074_-|hypothetical-protein	unknown	unknown	unknown
CP034463.1|AZP23786.1|10342351_10343533_-|hypothetical-protein	unknown	unknown	gnl|CDD|271175
CP034463.1|AZP22972.1|10363167_10364415_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197775

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034463.1|AZP22963.1|10346845_10347856_+|hypothetical-protein	gnl|CDD|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	3.89884e-32
CP034463.1|AZP22967.1|10353863_10354811_-|IS481-family-transposase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.29934e-15
CP034463.1|AZP22965.1|10349261_10350257_-|ATP-dependent-DNA-ligase	gnl|CDD|185714	cd07905, Adenylation_DNA_ligase_LigC, Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases. Bacterial DNA ligases are divided into two broad classes: NAD-dependent and ATP-dependent. All bacterial species have a NAD-dependent DNA ligase (LigA). Some bacterial genomes contain multiple genes for DNA ligases that are predicted to use ATP as their cofactor, including Mycobacterium tuberculosis LigB, LigC, and LigD. This group is composed of ATP-dependent DNA ligases similar to Mycobacterium tuberculosis LigC. ATP-dependent polynucleotide ligases catalyze phosphodiester bond formation using nicked nucleic acid substrates with the high energy nucleotide of ATP as a cofactor in a three step reaction mechanism. DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Members of this group contain adenylation and C-terminal oligonucleotide/oligosaccharide binding (OB)-fold domains, comprising a catalytic core unit that is common to all members of the ATP-dependent DNA ligase family. The adenylation domain binds ATP and contains many of the active-site residues. The common catalytic core unit comprises six conserved sequence motifs (I, III, IIIa, IV, V and VI) that define this family of related nucleotidyltransferases.	4.89786e-63
CP034463.1|AZP23787.1|10357215_10358388_+|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase	gnl|CDD|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	3.57953e-115
CP034463.1|AZP22968.1|10358406_10358826_-|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	8.11905e-44
CP034463.1|AZP22966.1|10351715_10353749_-|NACHT-domain-containing-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	6.11246e-09
CP034463.1|AZP22961.1|10340514_10341795_+|hypothetical-protein	gnl|CDD|374474	pfam16289, DUF4935, Domain of unknown function (DUF4935). This family consists of uncharacterized proteins around 350 residues in length and is mainly found in various species, such as Prevotella, Pseudomonas, Leptospira and so on. The function of this family is unknown.	4.94108e-13
CP034463.1|AZP23788.1|10359952_10360948_-|ATP-grasp-domain-containing-protein	gnl|CDD|237195	PRK12767, PRK12767, carbamoyl phosphate synthase-like protein; Provisional.	6.68127e-75
CP034463.1|AZP22962.1|10344846_10346064_-|site-specific-integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	6.96649e-18
CP034463.1|AZP22969.1|10358822_10359953_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl|CDD|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	1.92666e-108
CP034463.1|AZP22970.1|10360962_10361979_-|dTDP-glucose-4,6-dehydratase	gnl|CDD|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.53025e-163
CP034463.1|AZP22971.1|10362360_10362924_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	9.17657e-18
CP034463.1|AZP22973.1|10364405_10364936_+|N-acetyltransferase	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.9866e-09
CP034463.1|AZP23785.1|10341830_10342343_-|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000187945
CP034463.1|AZP23786.1|10342351_10343533_-|hypothetical-protein	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.08343e-05
CP034463.1|AZP22972.1|10363167_10364415_+|XRE-family-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.24304e-05

Protein sequences

>CP034463.1|AZP22967.1|10353863_10354811_-|IS481-family-transposase
MSKTTPLDREAKRRLAVIRHVEEVTGNVAMSCRYFGISRQAYYIWYRRYQAEGIEGLRTRSKAPKHSPNATHVEVVGKIIYLRQNYHFGPEKIAMYLKRYHDVTISKSGVWRILNRLDMGRLPASQRYKRHDRRWKRYEKKLPGHRVQIDVKFIEPLASMPQGRRGGRNKYFQFTAIDDCTRLRVLRIYPTLNQATAIQFLDYVIQRLPFQVEVIQTDNGAEFQSAFHWHVLDKGIAHTYIKPRTPRLNGKVERSHRIDAEEFYRLLEGVIIDDAEVFNDKLREWEDYYNYHRPHGGLGGQTPYERLKQKTTTQA
>CP034463.1|AZP22966.1|10351715_10353749_-|NACHT-domain-containing-protein
MAGLGGRRWRRRWQMFGALGALAVVASVAYAMRQLLHGGLEPGDTAGLLGLPLGVIGLVVSVVALRNPVEGNDAERSRGWAATLAKQVEDGESGVWRQLLGDDTRRINLAYDLQPAVSRPAVALAAGRLTADGANSATVPDIVSYYRATQPLRLVITGAAGAGKTVLALELLLALLDGRAEDDPVPVRIPLSRWDTERQLLPDLLRQRLVEAYDWPTDLAAGLVRQHLVLPVLDGLDEMDPLVDGSPDPAAPRATAVVRALNAYQQGRDAGPLILTCRTRHYDALATHAEVLDAARITIAPVDATDARTYLTDRALTTDRWQPLLDHLAAHPSGLLATVLSTPWRLCLTATVYHRDGDPGELRTLLDASTLDDHLLARYIPAATRIAPNPHGYAPKDVHRWLHHLTTHLDPTGALPATAPTSVEATDLLLHELWPLAGRTRVRTTDAVLTTLAVLPSAWTAPLKPTGLAALITALAVMSGALAITTGQPTSTANPLRTRQGRREFAFWLAGGLVLGLAIGLAIWLAIGLAAGPTVGLAAGFATALTVGLTREPGTNLGARAVIRSDAMAGLMFGLTFGLAVGLAGGLEIGLAAGLAAGLAMGLAAGLSAGLAGGARASRRYAVFLLCSRRRLPFRLGLFLDWAVTAGLMRYSGPAYQYRHRELQHWLRQHPQPADLP
>CP034463.1|AZP22965.1|10349261_10350257_-|ATP-dependent-DNA-ligase
MPASSPGWSLPEPMRAVPVTDPALPAGWAAQLKWDGYRALVGRWADGRVAVRSRNGGDLTASFPEIEEAVRLLPDDTAVDGELVVWEGGRLAFERLQQRMHRRGAAATRAAGELPAHLVAFDLLRLNGQGLTGWPFSDRYAALQELFLKHHLAAPWSLCATTTDPVQAAAWLADYPAVGIEGLVFRPLASRYVPGGRGWTKYKMRHTTEAVVGAVTGSLTAPTTALLGRYDDAGRLRYAGRTTTLSTTARQTLAGQLRTGGADYPWTGRTFSAGWSSREHLSVRLVVPEAVAEVAVDVARDSPGRWRHPVRFTRIRADMTLGDVPLFGAAP
>CP034463.1|AZP22964.1|10347898_10348582_+|hypothetical-protein
MLLEPPGWPGRPEGLPHWPYVRAVDDALAARGIPPGSVHADCTTREYGGLTTYMWLTWDASRTRYRSSGIRLHWQERRGWFYALTCLNTREILLYAPLAPLRTVVPDPEHVTDVAEQLVRFRQIPDMEYRTEWERGEELRAAARDFRRAVLGLPPLAHPETPTGPGGRPDAEQEQGMRLTIDTLTDTYEQALAAVQAIYGHNEDAPHRRSPTDLGQALRPTMEEHER
>CP034463.1|AZP22963.1|10346845_10347856_+|hypothetical-protein
MTTSAVTPDQVSTIMHVRCPDGLPEPAYRQLLELMAELSPIVQALPPSAAVVELKGALRYHGTDARRLGEILRIRSLSRLGVDVRVGIGPTITVAATASAQVPSPGGILAVAPGEADDWLGPLPVEALHGIGPRQAAVLRDYGIHCVGLLAAVPPATVHRLLGGRAGRIAADRARGIDPRPVVPRALPPAASVRCRFERHVLDGATVRAALLELVVRLGRQLRRRDQVARALTLTLTFAGNTRWEKTRRLVEPSAHDDDLRTLAYQLMDAAGLQRGRLTGLSLRGEDLIGADQAAEQISLDDAREARLVAETVVDRVRDKFGAGVIGPAAVFRRAS
>CP034463.1|AZP22962.1|10344846_10346064_-|site-specific-integrase
MWLCGGLLHDSWQEFGMRAFPVVMPSGQRYWTVLDDHLEVVSLADQWLRHLRFGRDRAELTTKAYAGSVALYLRWSGSTGRAWAEAGRDLGLFMVWLKYTPAPRDGVVPVVRAGPGAVPVRGERRINRVLVAVRGLLSYAVSVSEAPRSVLGQIYELADSRDLPAEAQGEDGGLFYRLRPVHSLREPETTVDRAADAALVAMFVACRNARDRLIVLLVGRVGLRRGQVAGLRRSDVHLLPDSRALGCDYPGAHVHVRRRENVNGAWSKSRPAWVAPLDFLVVSAFDLYYDERHRLLGMGGSDFLLVNLFRAPLGEPMSPEAIGELLERLSGRAGLDRRVGAHMARRAFASNVTDAGGQPDEVQAVLGQKSLDSQAPYLFPDPKRVRAAIERVPSPRGMAGPEDSR
>CP034463.1|AZP23786.1|10342351_10343533_-|hypothetical-protein
MPDEPEDTEAGRDLPDEVLRELCAHLDELEAQSSTEVRVATELLIDTGRRPDEINTLPFNCLEQDPDGSDVLVYDNHKAYRLGRRLPIGAETAAVIRRQQQRVRERFPTTAPARLRLLPRPKSNPEGTKPLVDVSGHHRAWVKSLPDILVPVVAADADTRVTRLVPFDKKRIFPYAYRHCYAQRHADAGVPVDVLKELMDHRLVSTTMGYYRVGDERRREAVDRVTALQFDRHGDRVWRTAKSLLDSEHVRRAIGEVAVPYGVCREPTNVAAGGHACPLRFRCLGCEHFSTDVSYLPDLQAHLADLLRSRERLMSAFEADDWARTQAMPSEEEIRRIRRLIERVQTDLDDLTPEDRAQIEQAVTVVRRSRTVMLGMPRVRQPLPDVRPARTPT
>CP034463.1|AZP23785.1|10341830_10342343_-|hypothetical-protein
MQDGRHAGTERRRQRVQDAIAAAVRDGTALTASAIAHAARVDRTFLYRHRDLLDNLHTASSRSTSPSPGSAPTVTTASLQADLANANARATRLAARVRHLEEHLSRQLGERAWHESGLSAPADIAELHAAVTHLEQRTVELSRDLEERQAELEAARAANRELTRALNQRG
>CP034463.1|AZP22961.1|10340514_10341795_+|hypothetical-protein
MDTNILRGFELQSPKAELLRAIKTADVGGVSVPWAALEELAGQRARTYHLAHEKAEAALRALAKSAPTGNSGVVAPLDHDRVLQYWRQRYLEIVDVIPTSANALEQATTREAAVLPPCKAVDIVNEEGKVIKTIKTGGRDTAIWLSAVEYATEHPQETVYFVSENIKDFGRGETYKYPMDRDVEKLGDRFVHLLKLEDILPQFSEEIDVPESDLDSALRGQGNLETIAFETRFGAPLRPSRHQTGWRRFRSTQLEEPTGAELPEGIAEVWLGNPNVSFASVRDAKAYRIGDHVWCTAWVTWLLSGHALLNRTLDIAEVGCAWETRVLVSLTDSTSKLDILRSSTPRAATAQEADNLPEVDPLILPDYIAELDDRIRRNRMSRNMRHYLGQASTAEEALDMMLGFARPSPLPLPTAEVEVWVEPDED
>CP034463.1|AZP22960.1|10339067_10340150_-|hypothetical-protein
MASHPLGLFPAHDADRHGKGKQKMHGLALYITHVWEAAATTDTSLCRVHGMEVDTERIALEVAPALAAIRTLDRDVICLSQTAAEQTRYLDFQKDDPQGRAVRGLLILRNADTHVPATIEVPADRVVGGVGLGYRVMPRWLSFDDLPDAIRNNPKNNPGAVQAYKDAVGGQLVMDTLLDAFAFIDRCDPTLARRVRGTDDLEYFPLHDYTTHDYDRLHPDQPSRPQLDAEIRRLTQETPPYGTGREILHSFNRDGQEVYCGNTIRHDIRTAFVEPGMQVTRDIRAGFPYSVITSDGTQHDVTVDEEGHLTAAGSPLASVPLQTPRNHCRPEVCEGWWELTTSDAFLYRQQRHLHEAIRDL
>CP034463.1|AZP23787.1|10357215_10358388_+|UDP-N-acetylglucosamine--N-acetylmuramyl--(pentapeptide)-pyrophosphoryl-undecaprenol-N-acetylglucosamine-transferase
MYNDHRRYFRLMVTGGGTGGHTYPALTAVRTLQSRLAAQGAGLDVVWVGEADSLESRVAVGEGIRFESVAVGKIRRSKNPIKLVSPANIADMSRVPLGVLQARKAITGFGPDVVLATGGYVAVPVGVAATRLCRVPLVVHEQTVRLGLANRTLAGAATRVAVSSPSTLPLLPESVRAAAVVTGNPVRPEVFTGQAQKAIHALGLHGFDARLPTVYVTGGAQGSQQVNHLVRDVLPWLLEHANVIHQCGPGNVDELRRQTAQLPAASAGRYHLAGYMGAELPDVFALADVVISRSGAGTIAELTALGKPAVFVPLATSAGNEQVHNARHLADAGAAVALTGEVTPGQLRAAVAPLLTDPERRAAMAERARAHGRPDAAERLVDVVLAAAGR
>CP034463.1|AZP22968.1|10358406_10358826_-|low-molecular-weight-phosphotyrosine-protein-phosphatase
MRNILTVCLGNICRSPYAASVLQHRGSWAVDARSAGLSDKWTGQPAHEEMLELAAARGFDLAGHRATQVTPELLEWADVVLAMDYKVLDELRRQADPTVFGKITFYLDDQDVPDPYDGTTDDFARAADLIQQGAHRHLP
>CP034463.1|AZP22969.1|10358822_10359953_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MGAVPLQVTMNARPYLHGPEAEALTEALQAGQYGHSAIVDRFEQAIADYLGVPDMVAVASGTAALQLALTTAGVAPGHEVIVPSQTFCASIHAILATGAHPRFVEINPDTLCTDAANVRDALTPKTRAIVPVLYGGRAVDLSTLHDELTRQRITIVEDAAHAFGSHCKDTFVGARPGVLTCFSFGPIKNLTCGTGGGIIPRTPPEAQELRTLRALGIVQSQTQRAATTSYTVQEFGLRATMSALNAAIGLAQLEHFEKVAAKRQELWRTYADGLHALDGVRLVDVDIDHTVPFNCVIHLTDRDRVFAALRASGLGVGVHYPPNHHQPAFKHWHRPLPVTERSARQLMSLPFHPSMNRDDVQYVLSALARSLATETP
>CP034463.1|AZP23788.1|10359952_10360948_-|ATP-grasp-domain-containing-protein
MRVLVTGTGGAPGFDLARHLIRLGCQVIAADANPLACGLVLAGVTPCLLPSSDDPDFGARLLDVCRRLRPEALISTIEWELPVLIAQREALAALGVRTWLPDAGTVTVTGDKAAFHSALTARGIPTPATWLPHQLDTAAVPGPFVVKPRRGHGTQNVHVCRTRAQAAVLCELVPDPVVQEHILGQEFTADCLVDRTGNASVILRHRLLVKAGLSVVGRTFHDDEAADLVKRTLDAVGMIGPCCVQGFQCAYGGVTVTEVNARFAGGFPLAVAAGAALVEQTLNGLLELPVDHTRLAYTPDVCLTKCFETVATGAWPPPPLHGLTEPAEGAS
>CP034463.1|AZP22970.1|10360962_10361979_-|dTDP-glucose-4,6-dehydratase
MEKILVTGGAGFIGSHFAARMLACEDVAKLTVIDALTYAGHKENLAAVLTSPKLSFVRGNILDQHLVDELVQRHDAVVHFAAESHVDRSFLEAGTFLTTNILGTHTLLDAARRHGVTKFVHVSTDEVYGPMPTGCATEQCALNPTVPYASSKAASDLLALSAFLTDGVPVCVTRSSNQYGPQQHPEKIIPLFITNLLKGQQVTLHGQGQHVRNWLHVQDNCSGIELVLRRGIPGEVYNIGGGTDQTSRELTGHLLRLCGADWNAVTYVPDRKCNDVRYAMDWSKARDDLGYRPVWSLMDGLAQTVDWYRAHPERWAPASRNTDAPMAALSITDTGEKK
>CP034463.1|AZP22971.1|10362360_10362924_-|ATP-binding-protein
MIAARLTPSGARRYTETLACEPASARRARLLVSAAVNAWGISEMSEAGMQIVAELVNNAVEHTRCRSVRVLVTRTTERRVRIAVADTCRETPEMGRPDGDAEGGRGLLLVDALSSRWGYDRDPLGKVVWAELEVPPTAEHQFAEALSLGTRTSRPRGDDAPPGSAPPSGSAAPCSHKAAPSAPRPPR
>CP034463.1|AZP22972.1|10363167_10364415_+|XRE-family-transcriptional-regulator
MAANAVLKRRMEELGLTQDELAGRMNTALAEITGRPGDVSARTVRNLLNGTSRRPIGRTCAALERVFGCSVQDLGFSAPRTMQHPQEDPVRRRTFIASATGTASAAVPLLAQRRTVGMSDVARAAKGMNALVTADQHQGGHTNLEMAALRGRNRVLELQQRNASERVRRALYALAAEYTDAAAWSCIDARNLDQAQKYLNESSTYAGLSQDGPTQMSVWVSMAIFAAQRRNWPEALSAAQAAQASPAARADLFFASLGRIRAALAYAALGDSRAALRSLGSAQEALAAAPERERPRWTTFYCQAELDHLGAIVNHRSGRYTHAEAMAHRALAKIPPSFRRNRALATAQLALAQLHQGDSEQATATAADVFTVMAGTPLPGRMRTLIGDFHRALFTMAPSATYARDWADRLRTEWS
>CP034463.1|AZP22973.1|10364405_10364936_+|N-acetyltransferase
MELNVIEMRHFRHGHLPEGFRQLLIDVHADAYADQMDDPFNQRFDWFVEHWSSAEGFTCVVAYDGDQPAGFAYGAPATPGREWWRDAKYEPKAGRTSTYSVSELMVRPKWRKQGISERLHEALLKERTEDLAVLLVEVDHPKVQALYESWGYVKVGERQPFADSPLFAVMVKDLPG
>CP034463.1|AZP22974.1|10364849_10365074_-|hypothetical-protein
MLTSCLTDYCRHELTLCGIFTGREPPLSTPPSPAASKPLAHARWTASAWQVLNHDGEQWGVGKGLSFPDLHVAP
>CP034463.1|AZP22975.1|10366374_10367130_-|hypothetical-protein
MTSRREPRLADAAQIAAEHDLTPARISSLYTSREHNTAGQTFPEPVATRGRARLWDHAEVTEWFAHRTPTRLKGYKPPARDPQELLNAAEASRFLGYKNPNQVTTFVRDHPGYFPDPDVVEELGTPDNPYRRQQWRVQTLLNWLESRPGRGRRAGTKPAPPLPDVPVDGDPDELLGASEAAALLGYKSLSSFSSSLSQGNLPLLKTTDGIAENAGRQNGRRRWTRRRILEQAAQRSRRWAPAVSGTGRTAP

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP034463_2	2.1|310340|28|CP034463|CRISPRCasFinder	310340-310367	28	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	567650-567677	5	0.821
CP034463_2	2.1|310340|28|CP034463|CRISPRCasFinder	310340-310367	28	CP054917	Streptomyces sp. NA02950 plasmid unnamed, complete sequence	61973-62000	6	0.786
CP034463_2	2.1|310340|28|CP034463|CRISPRCasFinder	310340-310367	28	NC_011879	Pseudarthrobacter chlorophenolicus A6 plasmid pACHL01, complete sequence	132959-132986	6	0.786
CP034463_2	2.1|310340|28|CP034463|CRISPRCasFinder	310340-310367	28	NZ_CP049749	Rhodococcus fascians A21d2 plasmid pA21d2, complete sequence	142522-142549	6	0.786
CP034463_4	4.1|3400094|33|CP034463|PILER-CR	3400094-3400126	33	NZ_CP012185	Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence	114339-114371	6	0.818
CP034463_4	4.1|3400094|33|CP034463|PILER-CR	3400094-3400126	33	NZ_CP012182	Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence	37694-37726	6	0.818
CP034463_7	7.1|10354916|31|CP034463|CRISPRCasFinder	10354916-10354946	31	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	305361-305391	6	0.806
CP034463_7	7.1|10354916|31|CP034463|CRISPRCasFinder	10354916-10354946	31	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	110196-110226	6	0.806
CP034463_7	7.1|10354916|31|CP034463|CRISPRCasFinder	10354916-10354946	31	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	357543-357573	6	0.806
CP034463_1	1.1|39041|32|CP034463|CRISPRCasFinder	39041-39072	32	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	110195-110226	7	0.781
CP034463_1	1.1|39041|32|CP034463|CRISPRCasFinder	39041-39072	32	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	357542-357573	7	0.781
CP034463_2	2.1|310340|28|CP034463|CRISPRCasFinder	310340-310367	28	NC_004808	Streptomyces rochei plasmid pSLA2-L DNA, complete sequence	107015-107042	7	0.75
CP034463_2	2.1|310340|28|CP034463|CRISPRCasFinder	310340-310367	28	MN234170	Mycobacterium phage MalagasyRose, complete genome	46232-46259	7	0.75
CP034463_4	4.1|3400094|33|CP034463|PILER-CR	3400094-3400126	33	NZ_CP023549	Rhodobacter sp. CZR27 plasmid unnamed1, complete sequence	331024-331056	8	0.758
CP034463_4	4.1|3400094|33|CP034463|PILER-CR	3400094-3400126	33	NC_049470	Arthrobacter phage TripleJ, complete genome	7741-7773	8	0.758
CP034463_4	4.1|3400094|33|CP034463|PILER-CR	3400094-3400126	33	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	2439594-2439626	10	0.697

1. spacer 2.1|310340|28|CP034463|CRISPRCasFinder matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 5, identity: 0.821

agtcggtcggtgggggcgagtcggtcgg	CRISPR spacer
atccggtcggtgggggcggggcggtcgc	Protospacer
* .***************.* ****** 

2. spacer 2.1|310340|28|CP034463|CRISPRCasFinder matches to CP054917 (Streptomyces sp. NA02950 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

agtcggtcggtgggggcgagtcggtcgg	CRISPR spacer
tgggcctcggtgggggtgagtcggtcgg	Protospacer
 *    **********.***********

3. spacer 2.1|310340|28|CP034463|CRISPRCasFinder matches to NC_011879 (Pseudarthrobacter chlorophenolicus A6 plasmid pACHL01, complete sequence) position: , mismatch: 6, identity: 0.786

agtcggtcggtgggggcgagtcggtcgg	CRISPR spacer
gggtggtcggtgggggttagtcggtcgt	Protospacer
.* .************. ********* 

4. spacer 2.1|310340|28|CP034463|CRISPRCasFinder matches to NZ_CP049749 (Rhodococcus fascians A21d2 plasmid pA21d2, complete sequence) position: , mismatch: 6, identity: 0.786

agtcggtcggtgggggcgagtcggtcgg	CRISPR spacer
cgcgtgtcggtggcggcgaggcggtcgg	Protospacer
 *.  ******** ****** *******

5. spacer 4.1|3400094|33|CP034463|PILER-CR matches to NZ_CP012185 (Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence) position: , mismatch: 6, identity: 0.818

atgtcaccgactccagcggcccgctcgacctga	CRISPR spacer
atgtcaccgactccggcggccggctcaccatgg	Protospacer
**************.****** ****. * **.

6. spacer 4.1|3400094|33|CP034463|PILER-CR matches to NZ_CP012182 (Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence) position: , mismatch: 6, identity: 0.818

atgtcaccgactccagcggcccgctcgacctga	CRISPR spacer
atgtcaccgactccggcggccggctcaccatgg	Protospacer
**************.****** ****. * **.

7. spacer 7.1|10354916|31|CP034463|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.806

gggcggggtggctccggcccccgaggactgc	CRISPR spacer
gtgggggctggctccggcccccgaggccgac	Protospacer
* * *** ****************** * .*

8. spacer 7.1|10354916|31|CP034463|CRISPRCasFinder matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

gggcggggtggctccggcccccg--aggactgc	CRISPR spacer
gggcggggtggatccggccaccggcaggatc--	Protospacer
*********** ******* ***  ****..  

9. spacer 7.1|10354916|31|CP034463|CRISPRCasFinder matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.806

gggcggggtggctccggcccccg--aggactgc	CRISPR spacer
gggcggggtggatccggccaccggcaggatc--	Protospacer
*********** ******* ***  ****..  

10. spacer 1.1|39041|32|CP034463|CRISPRCasFinder matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

ggcagtcct--cgggggccggagccaccccgccc	CRISPR spacer
--tgatcctgccggtggccggatccaccccgccc	Protospacer
  ...****  *** ******* ***********

11. spacer 1.1|39041|32|CP034463|CRISPRCasFinder matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.781

ggcagtcct--cgggggccggagccaccccgccc	CRISPR spacer
--tgatcctgccggtggccggatccaccccgccc	Protospacer
  ...****  *** ******* ***********

12. spacer 2.1|310340|28|CP034463|CRISPRCasFinder matches to NC_004808 (Streptomyces rochei plasmid pSLA2-L DNA, complete sequence) position: , mismatch: 7, identity: 0.75

agtcggtcggtgggggcgagtcggtcgg	CRISPR spacer
cgtcggtcggtgggggcgggtcagagcc	Protospacer
 *****************.***.*    

13. spacer 2.1|310340|28|CP034463|CRISPRCasFinder matches to MN234170 (Mycobacterium phage MalagasyRose, complete genome) position: , mismatch: 7, identity: 0.75

agtcggtcggtgggggcgagtcggtcgg	CRISPR spacer
gcacggtcggtgagggcgagtcggaggt	Protospacer
.  *********.***********  * 

14. spacer 4.1|3400094|33|CP034463|PILER-CR matches to NZ_CP023549 (Rhodobacter sp. CZR27 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.758

atgtcaccgactccagcggcccgctcgacctga	CRISPR spacer
ccggcaccgacttcggcggcccgctcgacgagg	Protospacer
 .* ********.*.**************  *.

15. spacer 4.1|3400094|33|CP034463|PILER-CR matches to NC_049470 (Arthrobacter phage TripleJ, complete genome) position: , mismatch: 8, identity: 0.758

atgtcaccgactccagcggcccgctcgacctga	CRISPR spacer
aagtcaccgcctccagcgacccgctcctcatcg	Protospacer
* ******* ********.*******  * * .

16. spacer 4.1|3400094|33|CP034463|PILER-CR matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 10, identity: 0.697

atgtcaccgactccagcggcccgctcgacctga	CRISPR spacer
tcggcaccgacttcggcggcccgctcgatgccg	Protospacer
 .* ********.*.*************. . .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	39176 : 84251	36	Mycobacterium_phage(50.0%)	integrase,transposase	attL 32731:32747|attR 57172:57188
DBSCAN-SWA_2	10251453 : 10310934	50	Ostreococcus_lucimarinus_virus(16.67%)	integrase,transposase	attL 10254036:10254050|attR 10265320:10265334

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP034463|39176:84251|DBSCAN-SWA
CATGTCGAAGACAACCCCGCTCGATCGCGAGGCCAAGCGGCGCCTGGCCGTCATACGCCATGTCGAAGAGGTCACCGGCAACGTTGCTATGAGTTGCCGGTACTTCGGCATCAGTCGGCAGGCCTACTACATCTGGTACCGCCGTTACCAAGCCGAGGGCATCGAGGGGCTGCGCACGCGCTCGAAGGCCCCCAAGCACAGCCCGAACGCCACCCACGTTGAGGTAGTCGGGAAGATCATCTACCTCCGGCAGAACTACCACTTCGGGCCAGAGAAGATCGCGATGTACCTCAAGCGGTATCACGACGTCACGATCAGCAAGTCGGGCGTGTGGCGGATCCTGAACCGCCTGGACATGGGCCGTCTGCCGGCCTCTCAGCGGTACAAACGCCACGACCGCCGATGGAAGCGGTACGAGAAGAAGCTGCCCGGCCATCGGGTGCAGATCGACGTGAAGTTCATCGAACCACTTGCCTCGATGCCTCAGGGCCGCCGCGGTGGGCGCAACAAGTACTTCCAGTTCACCGCGATCGACGACTGCACCCGGCTGCGAGTCCTGCGGATCTACCCAACGCTGAACCAAGCGACCGCGATCCAGTTCCTCGACTACGTCATCCAGCGCCTGCCGTTCCAGGTCGAGGTCATCCAGACGGACAACGGCGCCGAGTTCCAGTCTGCGTTCCACTGGCACGTATTGGACAAGGGCATTGCCCACACCTACATCAAGCCGCGAACACCGCGCCTGAACGGCAAGGTTGAGCGCTCTCACCGCATCGACGCCGAGGAGTTCTACCGGCTCCTCGAGGGCGTCATCATCGACGACGCCGAGGTCTTCAACGACAAGCTGCGTGAGTGGGAGGACTACTACAACTACCATCGCCCGCACGGCGGCCTTGGCGGCCAGACACCTTACGAACGCCTCAAGCAGAAGACCACGACTCAGGCGTAACCGGTGATCGTCAGTTGCACACCGACAGACTCGGGCTGTCGGGTTGTCCGTCCGCCTGGTCACGAGTGGGAGAAGTCGCCGTTGTGGGGAGCTCGCGGTGGTGATGATCGGGGGGTGGCAGGACTCGGGGGGCGCCGCTGGCGGCGCAGGTGGCAGATGTTCGGGGCTCTGGGTGCCCTGGCGGTCGTGGCGAGTGTCGCGTATGCGATGCGACAGTTGTTGCACGGTGGTCTGGAACCGGGTGACACCGCCGGGCTGCTGGGTCTGCCCCTGGGGGTAATCGGGCTCGTGGTCTCCGTGGTCGCATTGCGCAATCCGGTCGAGGGCAACGATGCTGAGCGTTCCCGTGGTTGGGCCGCGACGCTGGCCAAACAGGTTGAGGATGGGGAAAGCGGGGTGTGGCGGCAGTTGCTGGGTGACGACACCCGGCGCATCAACCTTGCCTATGACCTGCAACCTGCTGTCTCCCGCCCCGCCGTGGCGTTGGCGGCCGGACGGTTGACCGCCGACGGAGCAAATTCGGCGACGGTGCCGGATATCGTCTCTTATTACCGAGCCACCCAGCCTCTGCGCTTGGTCATCACCGGCGCTGCCGGGGCCGGCAAGACCGTCCTCGCCCTGGAACTACTCTTGGCCCTCCTGGACGGCCGGGCCGAGGACGATCCCGTTCCCGTGCGTATCCCGCTGTCCCGATGGGACACTGAACGCCAGTTGCTGCCCGACCTGCTGCGGCAGCGGTTGGTGGAGGCCTATGACTGGCCCACCGACCTGGCGGCCGGCTTAGTGCGGCAGCATCTGGTGCTGCCGGTGTTAGACGGCCTGGACGAAATGGACCCCCTGGTCGATGGCTCCCCCGATCCTGCCGCGCCCCGCGCCACCGCCGTCGTCCGCGCGCTCAACGCCTACCAGCAGGGCCGTGACGCCGGGCCTCTCATCCTGACGTGCCGCACCCGGCACTACGACGCTCTAGCCACACATGCTGAGGTGCTGGATGCCGCCCGCATCACCATCGCCCCCGTTGACGCCACCGACGCCCGCACCTACCTCACCGACCGCGCCCTCACAACGGACCGCTGGCAGCCCCTACTCGACCACCTGGCTGCCCACCCCAGCGGACTCCTGGCGACGGTACTTTCCACCCCCTGGCGACTGTGTCTGACTGCCACCGTCTACCACCGCGACGGTGACCCCGGGGAACTCCGCACTCTCCTCGACGCGAGCACCCTGGACGACCATCTACTGGCCCGGTACATCCCCGCGGCCACCCGCATCGCGCCCAACCCTCACGGGTACGCGCCCAAGGACGTCCACCGCTGGCTCCACCACCTCACCACCCACCTCGACCCAACCGGCGCCCTCCCCGCCACGGCCCCTACATCTGTGGAGGCCACCGATCTGCTCCTGCACGAACTGTGGCCCCTCGCCGGACGCACCCGCGTCCGCACTACCGACGCCGTCCTCACCACTCTCGCCGTCCTCCCGTCCGCCTGGACAGCCCCCCTAAAGCCGACAGGGCTCGCCGCCCTGATCACTGCGCTTGCCGTCATGTCCGGAGCCCTCGCCATCACAACCGGCCAGCCCACAAGTACGGCGAACCCGCTCAGGACCCGTCAAGGACGCAGGGAGTTCGCGTTCTGGCTTGCAGGCGGGCTCGTACTCGGGCTCGCGATCGGGCTCGCGATCTGGCTCGCGATCGGGCTCGCAGCCGGACCCACAGTCGGGCTCGCAGCCGGATTCGCGACCGCACTCACGGTCGGACTCACGCGTGAGCCGGGTACAAATCTCGGAGCCCGGGCCGTCATCAGGAGTGACGCCATGGCCGGACTCATGTTCGGACTCACGTTCGGGCTCGCAGTCGGGCTAGCAGGCGGCCTCGAAATCGGGCTCGCGGCCGGGCTCGCAGCCGGACTCGCAATGGGGCTCGCGGCCGGACTTTCGGCCGGACTCGCGGGCGGTGCCCGGGCTTCGCGGCGGTATGCGGTGTTCCTGCTCTGCTCGCGCCGCCGTCTGCCGTTCCGGCTCGGCCTCTTCCTGGACTGGGCTGTCACCGCAGGACTCATGCGCTACAGCGGACCCGCCTATCAGTACCGCCACCGCGAACTCCAGCACTGGCTCCGCCAGCACCCCCAACCAGCGGACCTTCCCTGAAACTCGGGGCGTCGCATTGCCGGTAGCCGCCACGCCCTCAATTCCGTTCGCGGGTGGGGTTGTACGGCGTGGTCGGGGGTGGGGTTATCGCATCGTGATGCTGGTCGGGCCTTCATGGTCGGTGGTCTGGTCAGGGCCGGCTGCTGGCCTGTCCCGTAGGCGCGGCGCCGGTGGTGGTGCCGCCCCGTACGGGAGGCGGCGGGTCATGGTGAAGAGGGATGCGGGTGGCGGGGACCGGTTGGCGTTGACGGTCCTGGCGCAGCACCGGATGGCTACCACTGAGCAGATGCATCTGATGATCGGGCCGGGGGTGCGGATCGAGCAGACGAGGCGGCGGCTGGTGAAGCTGCGGGGTGAGGGGTGGGTTGGTTGATCGTGTGACGTTGCCTCAGGCGGGCCGGATGCGGGCCTGGTTCGTCACCGAGTACGGGGCGGAGGTTGTTGGTGGGTTCGCGGAGTTGCGGGGCTGGCGGCCGTCCCGGCTGGGAGCCGACCGTACGGCGGTCCGTCTGCGGGCGGGGCACGTGTTGACGGTGACGGAGACCGCGCTGGCGTTCGTGCAGGACGCCTGCCGCTGCGGGGATGTGTGCCGGCCCTTGGACTGGATCCCTGAAGTGCACCACCCCTTGGGGGGTGGCGAGGCCGTCATTCCCGACGCCCTGCTCTACTACCGGCGCGGCGGTGAGGGTGAGCGGGACTGGTCGATGTTGCGGGCGTTCGTGGAGGTGGACCGGGCCACCATGAGGCCCGAGCGTGTGGCGGCGAAGATCCGGGCCTATGAGCGGCTGTATCGGTATGTACCGACTCCTGTCGGCCGGCCGCGCGGGAGCGCTGTTCTCGAGGAAGAGTGGCGGCGGTATCCGCTCTTCCCGCGTCTGTTGTTCGTCCTGGACGGCACCGGCCCCGCCGGGGTGGAGAACCGGCTGAGTGCACTGCGCGCGGCCGCCCGGCTGGCCGGCGCCGATTTCGCGCGACAGGTACCCATCCTCGCGGCCCCGCTGACGGAGCTGCTCCGTGCGGGGCCCTCTGCACCCGTCTGGCAGCCGATGACCGAGGCCGGGCAGTGCGTTCCTGGGTTGCGCCCTTGGCAGGCTGACAGGCTGCCAAGGGCTGGCTTTGGTGCGGCGTCGACCGGACGGCAAGCCCGACCATGGGCCTGACCACACCCCGACCATGGGCCCGACCACGGTCTCCCCGCCCCCAGCCACAGGGCTGACCATGCAGGTCATAGGCCTGCGCAATCAGATGGGGCGTTGTGCACCAGCCATAGCCGCCCACCGCCCCCTTGAGTGCGCAGACGTGCGAAGCTCCCGGCCGCTTGCGCAGCAGGACCGGCCTGGTGCGCACTCGCTGCGCACCGGCCGTCTGCGTGATTGCGCAGCTGATTGCGCAGCCTGTCGGCGCGGCCGTTGGTGGGCGGTGTGCAGGAGATGCCGCCCAGGGTGGAAGGGGTTGAGCATGCCTGCTTCCTCACCCGGCTGGTCGCTGCCGGAGCCCATGCGCGCCGTGCCCGTCACCGACCCGGCGCTCCCGGCCGGGTGGGCGGCGCAACTCAAGTGGGACGGCTACCGTGCACTGGTTGGCCGGTGGGCTGATGGCCGGGTCGCGGTGCGCAGCCGTAACGGCGGCGATCTGACCGCATCGTTCCCCGAGATTGAGGAGGCCGTTCGCCTGCTTCCCGACGACACGGCGGTTGATGGCGAGCTGGTCGTGTGGGAGGGCGGACGGCTCGCGTTCGAGCGGCTGCAGCAGCGCATGCACCGCCGCGGCGCGGCCGCGACCCGCGCGGCCGGCGAGCTCCCCGCGCATCTGGTTGCGTTCGACCTCCTGCGCCTGAACGGCCAGGGCCTCACCGGCTGGCCCTTCAGCGACCGCTATGCCGCGCTGCAGGAGCTGTTCCTCAAGCATCATCTGGCCGCGCCGTGGTCGCTGTGTGCGACCACGACCGACCCGGTGCAGGCGGCCGCCTGGCTGGCCGACTACCCGGCCGTCGGCATCGAAGGCCTGGTGTTCCGGCCTCTGGCGAGCAGGTACGTGCCGGGCGGGCGCGGCTGGACCAAGTACAAGATGCGCCACACCACGGAGGCAGTCGTCGGCGCGGTCACCGGCAGCCTCACTGCCCCCACGACCGCCCTGCTCGGCCGCTACGACGACGCCGGCCGGCTCCGGTACGCAGGCCGCACCACCACCCTCAGCACGACCGCGCGCCAGACTCTCGCCGGGCAGCTGCGCACCGGTGGCGCCGACTATCCCTGGACAGGCCGCACCTTCAGCGCTGGGTGGAGTTCAAGGGAGCACCTGTCGGTGCGCCTGGTCGTACCCGAAGCAGTTGCCGAAGTCGCCGTGGACGTCGCCCGGGACAGCCCCGGGCGCTGGCGCCACCCGGTCAGGTTCACCCGCATTCGAGCCGACATGACACTAGGCGACGTGCCACTGTTCGGGGCGGCTCCCTAACAGGTCACCATCAAAGGCGACCAACCTGCGCGGGTTTGAGGGCCCGACAGCCTCGGCTCATGCGGTTTCCGGATGGCAGCCATGCGAGACATTCGCTTGTCGCATATGGCCCCTCTCCCTAGGGTCGACGCCGTGGGCAACACCGCCTTCCCGCGCCACCACGTGGGCGCGGCTGCGGTAAACCGCCAGACAGCCGTAAAGAGCTGTCGTCGGCGGACGTGCTGAACGAGATCGACAGGGAGACGCGATGCGCAAAGCAGTAATCAGCTTGTTCGTGGCGCTGGCGGCCGTGCTCGCCGTAACCCCCCTCACCACCGCCGGCCACACCGACACCGTCGCCTGCTGCGGTCAAACCCCCAAGTAGGAGACGCTCACCCGTACTTCGGCGCAGCAGTAGGGGCCCGTCAGCTCTTCGACAGGCCCTTGGTCACTTCGGGAGTGCGCAGTTCAGGTGGGCCTGGCAGTAACGAGATCGACAAGGAGACGCGATGCGCAAAGCAGCAATCGGCTTGTTCGTAGCACTGGCAGCAGTGCTCGCCGTAACCCCCCTCACCACCGCCGGCCAGTCCGACACCGTGGCCTGCTGCGGGCAAAACCCCAAGTAGGAGACCCTCACCCGTACTTCGGCGCAGCAGTAGGGGCCCGTCAGTTCCTCGGCGGGCCCTTCTTCCTTGAGCTGTCACCGCTCATGTTCTTCCATGGTCGGCCGGAGTGCTTGCCCGAGGTCGGTCGGTGAGCGGCGGTGCGGGGCGTCCTCGTTGTGTCCGTAGATGGCCTGCACGGCGGCGAGTGCCTGTTCGTAGGTGTCGGTGAGGGTGTCGATCGTCAGCCGCATGCCCTGCTCCTGCTCCGCGTCCGGTCTGCCGCCGGGGCCGGTGGGCGTCTCGGGGTGTGCGAGTGGCGGCAGGCCAAGCACGGCGCGGCGGAAGTCGCGGGCGGCGGCCCGGAGTTCCTCTCCTCGCTCCCACTCCGTGCGGTACTCCATGTCGGGGATCTGGCGGAAGCGGACCAGCTGTTCGGCGACGTCCGTGACGTGCTCCGGGTCGGGGACGACGGTGCGCAGCGGGGCGAGCGGCGCGTAGAGAAGGATCTCCCGGGTGTTGAGGCAGGTGAGGGCGTAGAACCAGCCGCGGCGTTCCTGCCAGTGCAGGCGGATGCCGCTGCTTCGGTAGCGGGTGCGGCTGGCGTCCCAGGTCAGCCACATGTAGGTGGTCAGGCCGCCGTACTCGCGGGTGGTGCAGTCGGCGTGTACCGAGCCGGGCGGGATGCCGCGTGCAGCGAGCGCGTCGTCGACGGCCCGCACATAGGGCCAGTGCGGCAGTCCTTCGGGTCGGCCTGGCCATCCGGGCGGCTCAAGCAGCACGGACCTCACCCCCACAAGCATCGGGAGCGGACGGCGTGCGGGTCATGAGGCGCGGCGGAAGACGGCGGCCGGGCCGATGACGCCCGCACCGAACTTGTCCCGAACCCGGTCGACCACGGTTTCGGCGACCAGGCGGGCTTCACGGGCGTCGTCCAGGCTGATCTGCTCGGCGGCCTGGTCCGCGCCGATGAGGTCCTCACCCCTGAGCGACAGTCCGGTCAGCCTGCCGCGTTGCAGGCCGGCGGCGTCCATCAGCTGGTAGGCGAGGGTGCGCAGGTCGTCGTCGTGGGCGGACGGCTCCACCAGGCGCCGGGTCTTCTCCCATCGGGTGTTGCCGGCGAAGGTGAGGGTGAGGGTCAGGGCGCGGGCCACCTGGTCGCGACGGCGCAGCTGGCGTCCGAGCCGGACGACGAGTTCGAGCAGGGCGGCACGCACGGTGGCACCGTCCAGGACGTGCCGCTCGAAGCGACACCGCACGGAGGCGGCCGGAGGCAGGGCGCGGGGGACGACGGGGCGCGGGTCGATGCCGCGGGCACGGTCCGCGGCGATGCGGCCAGCGCGGCCGCCCAGCAGACGGTGCACGGTGGCGGGCGGGACGGCCGCGAGCAGGCCGACACAGTGGATGCCGTAGTCACGCAGCACCGCCGCCTGCCGCGGGCCGATGCCGTGCAGGGCCTCCACCGGCAGCGGCCCCAGCCAGTCGTCCGCCTCGCCCGGGGCGACGGCGAGGATGCCGCCCGGAGACGGGACCTGGGCGGAGGCGGTGGCCGCCACCGTGATCGTGGGGCCGATACCGACACGGACGTCGACGCCGAGGCGGGACAGGGAGCGGATCCGCAGGATCTCCCCCAGACGGCGGGCATCGGTGCCGTGATAGCGCAAAGCCCCCTTCAACTCCACCACAGCCGCGCTCGGCGGCAGGGCTTGGACGATCGGCGAGAGTTCCGCCATCAGTTCCAGTAGCTGCCGGTAGGCGGGCTCTGGCAGCCCGTCCGGGCACCGCACATGCATGATCGTCGACACCTGGTCCGGTGTCACCGCGCTCGTGGTCATCACCGTCACCTCCCACACCCCACGTTATCGAACGCAAAATCGAACACGCGAGGGCACGGGGAAGGATCATGGGCCTAGAATCGGCAATGTGTTCGATGATCTGCCGCCCGACCTGGAGCGCCTTCACACCCTGCGGGTCTGGCATGCCCTGTGGATCGAGCGCATCGACCGCAAGATCGAAGCCCTCCGGCAGCGGGAACGCGAGCAGGAACGCGGCCGCCGCAACCGGCCCGCCCCGCCGGAGTGGATCGTCGGACTCGGCATCGGCGCGGGCCACCCGCCCGTCCAGGTCCACGCCGGCGACTGCTACGCGGCAGGCAAACGCCGCCGCCCTGTCGACCGCGACGAAGCCCGCCGCCTGCTCGCCACGGGCCTGCCCGGCTGCACCCACTGCCAGCCCGACGTCCAGCTCCACATCATCGACTTAGCCGCCCGCCGCCCGCCGGGCCGGGCGCAGCAACACCGACGCACGGTTTGGGGCATTCTGACACCGGCGTGGCTCGAACAGTCGTGTCATTCGGCCGGTTATCCTGCGGGAAGGCGGCTGGTCTTCGCCGCCCAGAACAGGACGCACGATGTCGACTCCCCCTCCCCCGGCCTCCGAACCGGACCCGTCCGCGCTGACCTGCCCCGGCGACCAGGTCGGCCTGTGTGCCGGATGCCAGCGCAAGACACACCGCTACGGCAACGGCGGCTGCCCGATTTCTCTCGGGGTGGACCGGCTGTGGTGTGACGTGGGGTGAGGCGGGTTCGTTGACCCTCGGGGACTCGTTCTCGGGGGGTGTGGCTCTGCGGCGGGTTGTTGCACGACTCGTGGCAGGAGTTTGGGATGCGAGCGTTTCCCGTGGTGATGCCGTCCGGGCAGAGGTACTGGACGGTCCTTGATGACCATTTGGAGGTCGTCTCTCTAGCTGATCAGTGGCTTCGGCATCTGAGGTTCGGCCGAGACCGGGCGGAGCTGACGACCAAGGCTTACGCCGGCAGTGTCGCGCTCTACCTGCGCTGGAGCGGATCGACGGGGCGGGCGTGGGCGGAGGCCGGGCGAGACCTCGGATTGTTCATGGTCTGGTTGAAGTACACCCCGGCCCCGCGGGACGGGGTGGTGCCGGTGGTGCGGGCCGGGCCCGGTGCCGTCCCGGTGCGCGGTGAGCGGCGGATCAACCGGGTGCTGGTCGCGGTGCGGGGTCTGCTGTCGTACGCGGTGTCAGTCAGTGAGGCACCGAGGTCGGTGCTCGGGCAGATCTACGAGCTTGCCGACAGCCGGGATCTTCCCGCGGAGGCACAGGGGGAAGACGGCGGCCTGTTCTACCGGCTGCGTCCGGTGCACTCGCTGCGCGAGCCGGAGACGACGGTGGACCGGGCCGCGGACGCCGCGCTGGTGGCGATGTTCGTCGCCTGCCGTAACGCGCGTGACCGGCTGATCGTCCTGCTGGTCGGCCGGGTCGGGCTTCGTCGCGGTCAGGTGGCGGGCCTGCGGCGCAGCGATGTCCATCTGCTGCCGGACTCCCGGGCGCTGGGCTGCGACTACCCGGGCGCTCACGTTCATGTGCGGCGGCGGGAGAACGTGAACGGGGCCTGGTCGAAGTCGCGGCCCGCGTGGGTGGCGCCGCTGGACTTCCTCGTGGTGTCCGCGTTCGACCTGTACTACGACGAGCGGCACCGGCTGCTCGGGATGGGCGGGAGCGACTTCCTGCTCGTGAACCTCTTCCGGGCGCCGCTGGGAGAGCCAATGTCGCCGGAGGCGATCGGCGAGCTCCTGGAACGGCTCAGCGGCCGGGCCGGACTGGACCGGCGGGTGGGCGCGCACATGGCGCGCCGGGCGTTCGCCTCCAACGTCACCGACGCCGGAGGCCAGCCGGACGAGGTGCAGGCGGTGCTCGGGCAGAAGAGCCTCGACTCACAGGCGCCGTACCTGTTCCCGGATCCGAAGCGGGTGCGGGCGGCGATCGAGCGGGTGCCATCGCCGCGTGGCATGGCCGGCCCGGAGGACAGCCGGTGACGGCCGCCAGCGCCCCAGCCCTGTCCGAGGCCGAGGCGCCGGACGAAGACCAGCGGGTGGGGGAGCTCCTGCGCGCCCTCGATGCCGATTTCCTGGCCCTGTTGGGGTGGGACTGGAACCGTCGCGTGATCACCTGGCCGCGCCGGCATCCGGTGATCGGGCTGCCGGACTGCCCGGTGCCGGGCTGCCCCTTGGCGATCACCGTGCTGACGCGACCGATGTGTGGGGGCTGCATGGAGCGGTGGCGCGGTTCCAGCCTCCCGCTCGACGAGTTTCTGCTCGTGCCGAAGGAGACGAGCCGCGGAGTCGGCGAGAGCCTGTGCGTGGTCGGAGGCTGCGAGCGGCCCCGCGACACAGTCGCCGGCCGGCTGTGCCAGGCCCACCACGCCCAGCACACGAACACGAGCTTGAGCGCCTTGAGCCTGGAGGAGTTCCTTACCCATCCTTGCGTGACGGGGTACGCCTCGTTCGGGCCGTGCGAGGTGGTCGCCTGCTACCTCGACCGAGCCGGTCGCCAGGACCCGTACTGCAAAGCACACGTGCGCCGCCTCTACCGGGCACGGTCGGCGCCCGGGTTCGACGAGGCGCACTGGCGCCGGACGGACAAGGCGATCTGCACCACCCGCGAGGTCAGTCTGCGCGGCTTGCCGGACCGCCTGGTCGCCGAGCTCCTCTACGGGCTGTGGGCCCGTACCCAGGAAGGAATGAAGGCACGGCCCGAGTGCCTGCGCCCGCTCTACGACCGGCTGCGCGCCCATCAGGTGCAGGAGCTGCAGGAGGTGACGGACCCGGCCGGTCACGGGCACAGCAGCGAGCAGGTCACGATGATCCGGGCCTGGCAGCGGGCGCTGCGCCTGCTGAACATGACGCCGGAAGCCGAGCGCGTGAAGGACGTCTGGGACATGGCGGTCTTCGGCTACACCGGCCGCATCTCGTTCGCGCCCGTGCTGCAGGTGCCGCTGCGGGAGGCGATGAAGGTCTGGGTGTACGACGACCTTCCCCGGCGCCGGAACAAGAACGCCGTCCAGCACGCCCGCGCGATCATCGCGGCCATCGGCATGCTCTCGGAGAGCTTGTGCCTGCAGCGTGAGGACCGCGGCGCAGTGCCTGCGGCGTGGGGGCGCGGCGACATCGTCGCCTTCACCAACCGCATGGGCTACTTCACCTCGACCGGGAAGATCAGCCCAGCGCGGCGCCTGGCCTTCACGCGGTTCGTCCGCAGGGTCCTGCTCCGCTTCCGCACCCTCGGCCTCACCGCTCGCGGGCAGCTGCTGGAGGGCATGCCGGCCGACTTCGCGGTCGGGCCGGAGGACATGCCCGACGAGCCCGAGGACACCGAGGCCGGCCGCGACCTGCCCGACGAGGTGCTGCGCGAACTGTGCGCCCACCTCGACGAGCTGGAGGCCCAGAGCAGCACCGAGGTCCGCGTCGCCACCGAGCTGCTCATCGACACCGGGCGGCGCCCCGACGAGATCAACACTCTGCCGTTCAACTGCCTGGAACAGGACCCGGACGGCTCCGACGTCCTGGTCTACGACAACCACAAGGCCTACCGGCTCGGCCGACGGCTGCCGATCGGGGCCGAGACCGCCGCGGTCATCCGCCGCCAGCAGCAGCGCGTCCGCGAACGCTTCCCCACCACCGCCCCGGCCCGGCTGCGGCTCCTGCCGCGCCCCAAGTCCAACCCGGAGGGCACCAAGCCACTCGTCGACGTCTCCGGCCACCACCGGGCTTGGGTGAAGTCCCTGCCCGACATCCTCGTCCCCGTCGTCGCCGCCGACGCAGACACCCGAGTCACGCGGCTGGTGCCGTTCGACAAGAAGCGGATCTTCCCCTACGCCTACAGGCACTGCTACGCCCAGCGGCACGCCGACGCCGGCGTCCCGGTCGACGTCCTGAAAGAGCTGATGGACCACCGCCTGGTCAGCACCACCATGGGCTACTACCGCGTCGGCGACGAACGCCGCCGCGAAGCCGTCGACCGCGTCACCGCGCTGCAGTTCGACCGCCACGGCGACCGGGTGTGGCGCACGGCGAAGAGCCTGCTCGACTCCGAACACGTCCGCCGCGCGATCGGCGAGGTCGCCGTCCCCTACGGCGTGTGCCGCGAACCCACCAACGTCGCCGCCGGCGGCCACGCCTGCCCATTGCGCTTCCGCTGCCTGGGCTGCGAACACTTCTCCACCGACGTCTCCTACCTCCCCGACCTCCAGGCCCACCTCGCCGACCTGCTCCGCAGCCGCGAACGCCTCATGTCCGCCTTCGAAGCCGACGACTGGGCCCGGACCCAGGCCATGCCCTCCGAAGAAGAGATCCGCCGGATTCGCCGCCTGATCGAACGCGTCCAGACCGACCTCGACGACCTCACCCCCGAAGACCGCGCCCAGATCGAACAGGCCGTCACCGTCGTGCGCCGTAGCCGCACCGTGATGCTCGGCATGCCCCGAGTCCGCCAGCCCCTCCCCGACGTCCGACCGGCAAGGACCCCGACGTGACCAGCCCGATGCAGGACGGCCGACACGCCGGCACCGAACGACGCCGGCAACGAGTCCAGGACGCGATCGCCGCCGCCGTACGCGACGGCACCGCTCTGACCGCCTCGGCGATCGCCCATGCGGCCCGAGTCGACCGCACCTTCCTCTACCGCCACCGCGACCTCCTGGACAACCTGCACACCGCGAGCAGCCGCTCGACCAGCCCGTCCCCCGGATCCGCCCCGACGGTCACCACGGCCTCGCTCCAAGCGGACCTCGCCAACGCCAACGCTCGAGCGACTCGTCTGGCCGCCCGCGTCCGGCACCTGGAAGAGCACCTGTCCCGTCAGCTCGGCGAACGGGCCTGGCATGAGTCCGGACTCAGTGCTCCGGCCGACATCGCCGAACTGCATGCCGCGGTCACCCACCTCGAACAACGCACCGTCGAACTCAGCCGCGACCTGGAGGAGCGACAGGCCGAACTTGAAGCGGCTCGCGCCGCGAACCGCGAGCTGACCCGAGCCCTGAACCAACGCGGCTGACGTGCCCGGGCCGGCCCGGTGCTGGTTATCCGGCCCTAGTCCTCGTCGGGCTCGACCCAGACCTCGACCTCTGCGGTCGGCAGCGGCAGCGGGCTAGGACGCGCGAAGCCCAGCATCATGTCGAGTGCTTCCTCCGCGGTGCTGGCCTGGCCAAGGTAGTGCCGCATATTCCGACTCATGCGGTTTCGCCTGATCCGGTCATCCAACTCCGCGATGTAGTCCGGCAGGATGAGGGGGTCCACCTCGGGGAGGTTGTCGGCTTCCTGGGCGGTCGCGGCTCGTGGTGTGCTGCTCCGCAAGATGTCGAGCTTCGAAGTTGAGTCCGTCAGGGAGACGAGTACTCGTGTCTCCCAGGCGCACCCAACTTCTGCGATGTCGAGCGTTCGGTTGAGAAGAGCGTGCCCGCTGAGCAACCACGTGACCCATGCTGTGCACCAGACGTGGTCACCAATGCGATATGCCTTCGCATCACGGACCGAGGCAAACGAGACGTTCGGGTTCCCGAGCCACACCTCCGCGATGCCCTCAGGAAGCTCCGCCCCCGTCGGCTCTTCCAGTTGAGTGCTTCTGAACCGACGCCACCCGGTCTGGTGGCGGCTGGGGCGCAGAGGCGCGCCGAAGCGCGTCTCGAAGGCGATCGTCTCCAGGTTCCCTTGCCCCCTGAGAGCGGAATCGAGATCGCTCTCAGGAACGTCGATCTCTTCCGAGAACTGCGGGAGGATGTCCTCCAGCTTCAGCAGATGTACGAAGCGGTCGCCGAGCTTCTCAACATCCCTGTCCATCGGGTACTTGTAGGTTTCGCCACGGCCGAAATCCTTGATGTTCTCGCTGACGAAGTAGACCGTCTCCTGTGGATGCTCCGTGGCGTATTCCACGGCCGACAGCCAGATCGCGGTGTCACGGCCACCAGTCTTGATCGTCTTGATGACCTTGCCTTCCTCGTTCACGATGTCGACCGCTTTGCATGGCGGAAGCACGGCTGCTTCGCGTGTCGTGGCCTGCTCGAGAGCGTTTGCGCTCGTCGGGATGACGTCGACGATCTCCAGGTACCTCTGCCTCCAGTACTGAAGGACCCGATCGTGATCCAGGGGTGCAACGACGCCGGAGTTGCCGGTCGGTGCGCTCTTGGCGAGGGCCCGCAAGGCCGCTTCGGCTTTCTCATGAGCCAGGTGGTAAGTCCGAGCGCGCTGCCCCGCCAGCTCCTCCAGAGCAGCCCAAGGGACTGACACCCCTCCTACGTCCGCTGTTTTGATGGCCCGAAGGAGTTCGGCCTTGGGACTCTGCAGCTCGAAGCCCCTCAGGATGTTCGTGTCCAAGATGATCAAGGTGGGGTGCTCCGTCTCCCTCGAATCCGAGTCGTACGGTCACACCCTCTCAAGTTCTGATCACCGAATGGGGGGCCTCAGGGCTACGACTCCCTCGGTCTGCACCTTGCCAGCACGAACACGTGCCGACCACGGTGTGCTCCGGGCCGGGATCGTAGATCACGGCCTCGTAACCCTCGTCGGTGTTCAACTGGACCAGGTGCAACGGCTCTTCGTCGCCGGGCTTCGGGTCATCCGTCACCCAACCAGGGTTGGGCGCGCTGCTGACGCCCCATCCGGGAAAACCGGGGCATCGCGCGGAGCTTGCGGTACGTTGATCTCTTCGCCGACGGGCGGAGTCCCGTAGGAGCACTCCATGGCCTCACATCCACTCGGCCTTTTCCCCGCCCACGACGCGGATCGTCATGGCAAGGGCAAACAGAAGATGCACGGCCTCGCCCTGTACATCACCCACGTCTGGGAAGCCGCTGCGACGACCGACACATCCCTGTGCCGTGTTCACGGCATGGAGGTGGACACCGAGCGCATCGCCCTTGAGGTCGCCCCGGCGCTCGCTGCCATCCGCACCCTAGATCGAGACGTCATCTGTCTCAGCCAGACAGCGGCCGAACAGACCCGGTACCTCGACTTCCAGAAAGACGATCCGCAGGGACGCGCGGTCCGCGGCCTTCTGATCCTGCGCAACGCCGACACCCACGTGCCCGCCACAATCGAAGTCCCGGCGGACCGTGTTGTCGGCGGTGTCGGCCTCGGCTACCGCGTCATGCCCCGATGGCTCTCGTTCGACGATCTGCCGGACGCCATCCGCAACAACCCCAAGAACAACCCCGGCGCCGTCCAGGCATACAAGGACGCGGTCGGTGGCCAGCTCGTCATGGACACCCTCCTCGACGCCTTCGCCTTCATCGACCGATGCGACCCCACCTTGGCGCGCCGGGTCCGGGGAACTGACGACCTTGAGTACTTTCCGCTGCACGACTACACCACGCACGACTACGACCGGCTCCACCCCGATCAGCCCAGCCGGCCGCAGCTCGACGCTGAGATCCGCCGGCTCACCCAAGAGACCCCGCCCTACGGCACCGGCCGGGAGATTCTCCACAGCTTCAACCGCGACGGTCAGGAGGTCTACTGCGGGAACACGATCCGCCACGACATCCGCACGGCCTTCGTCGAGCCAGGCATGCAAGTCACACGGGATATCCGCGCTGGGTTTCCGTACTCCGTCATCACCTCCGACGGCACCCAGCACGACGTCACCGTCGACGAGGAAGGTCACCTGACTGCTGCCGGCTCGCCGCTCGCCAGCGTCCCGCTGCAGACTCCACGCAACCACTGCCGCCCTGAGGTTTGCGAAGGCTGGTGGGAGCTGACAACCAGCGACGCCTTCCTGTACCGCCAGCAGCGGCACCTCCACGAGGCGATTCGCGACTTGTAGGGCTTCGGGTGCTGTCAGCGCCAAGGGTGAGAGGCGGGCGTCGGCCGTCGCGGGGTGGCTACGCGGCAACTCCTGCGTCGTCCACATCAGAGGCATCGACACACCTACGAGCCGCGTCTGGCTGCCACGCCGCCCCGGCAGCCAGGACCACGACGGTTCCACGGAAATTTCCTCGCGGCTTCCCTTCGCTCGATTCAGTGATGGCGCCACACCTGTTGCACCAGATAGCGTCAGAGACACCGGTGCTGAGCTGTGCTGACGCGTCCATCACCGACCTGCGCCACACCATCAGCCTGAGAGAACCCGATGTGCCAGTGGTGCATGGCACCCGTACAGGACAAATGGGGCCCCGCCGTGCGCTACACCAGCACCCGCGGCTGAGCGCGGCGATCCCGAAGGGCATCTGCCGACACCAGAAGCACCTTCCTACGGGCAGTACTGCACAGCGCTGGGCACACAGGTGTTCTTATGCCAGGCATCCCCGAACCCGACCGCGAAAACGATCGCGCTGACAACAAGAAGGCCAATGGCCAGAACCAGACTCGTCTCAGCCATGTTGCGCAGCCTGGGCACCACGGGAGCCGGCCCAGCCAAGGCGGCGTCGGCTCGGCCGTGCTTCTCGAAGAGAGCCGCCAATGCCGGGCGGACTTGTTCCTCAAACAGTCGTTCAGGCTCCGCTCCAATGGATCCGGCTCGGTGGAAAAGGTAGTCCGTCACCTTCGACATCTGCTGACCTCCCCTCGACGCGGCATGGGCTGTGCCTCTGAGCGCGAGGACGGCAACGCCGCCTCCCATACCCAGCACGCCCAGCACCAAAGGAATGAAGATGCTTCCTGTCGCCTGGCCTGCTTCGGCGGTAACGGTCAGCAAGGCGGTCATACCGGCCCCGGCGGCCCCGACCCACCAGGGCCACGTGGTGTGCAGGACGGCAGCAGAACCCAGGCTCAACATCTGCTCGGCGACCCACTTCCGCACGGCCTGGAGGCTGTTGCCAACGACATCATGCTTCTGCAGTTCCTCCACCAGGGGCGCCAGTTCCTTGCGCAATTCGTCGCCGTCATCCACCCGGCTGGCAACCCATGAGTCAGCGTCCGCGGCCGAAGCAGCGACCACGGCGTGCAGAATCCTTTTCGACAACGGCTCGGTGGCGAACAGCGCGTCCCCTTGGTCCAGGGTCCTGCTGTAGGCGTTGCGCAGAGCTCTGAGTGGGTGTTCTGTGAGCTTTCGTGGGGTCTCAGTCCGGGGATGGCGTTGGTTGCGGTAGCCGGAAGAGGCCGGGCTCCGGCTCGGTGAGAATGCCGCGGCTGACCAGGCGTTTCAGTTTCGCGCGGACGCCTTCGACATGCCGGGGTTCGGTGCCGGTGTCCAGGGCGATGCAGACGTCCTTGGGGCGCAGTCCGTCTGCGGTGTCTTCGAAGAGGGCGAGGATCTGACGGTAGGCCGAGGGCAGCGGAGCGAGGCCGCCGGGAAGGTCTGGTGCGATCTCCAGAATCGTCTCCCGGGTGATCCTCAGTCTCTCCAACGCCTTTTCGGCGGCCGCGAGTTGGGTGGTGAGCTCGGCGATCTGAGTGCGGAGTCTGTCCGCGAGGTCACGGCCGGCCGCCTCGCGGATCTCGAGCTGTTCCAGGAACTCCTGCATGCTCACGCTCACTCGTTCATGCCGGTCCGGGGGAAGCGGGTCGGCGGCGGTCCCGCCAGGTGGGAGTGGTCGTGGCGGTGAGCCGGTGGGTCATGACGTCGGTCATCGACCAGCGGATCCAGGACGCGGAACTGGCGGGCAGGGTCTCGTAGTCGCGGGCCAGGCGGCGGTGCAGCATGAGTGTGCCGAAGGTCTGCTCGACGATCCACCGCTTCGGTGACGGGGCGAACCCCTTCGCCTGCGGGTCACGCGATACCACCTCGACGTCGATGCCCAGCGACCTGCCGTGCTCGATGACGGCGTTCTTGAACCCGGCATCGACCCAGCTCTTCACCACGCCGGGGTTGTCGGCGGCCACCTTGTCCAGCAGCGTGATTCCGACGGCGTTGTCGTGCACGCTCGCGGCGACCACGATCACGGCGATGAGCAGACCGAGTACATCGGTGGCGATGCCCCGCTTGCGGCCCCGGCTCTTCTTGCCCGGGTCCAGCCCGGTCGTCTCCTTGGGGGCGTTGACCGAGGCGTGCACGGTCTGGGAGTCCATGACGACCGCGGACGGGTCCTCGCGCCGGCCCTTCGACTCGCGGACCTGCCAGCGCAGCAGATCGTGGATGGTCTGGTCGGTGCCGTCATCGCGCCACAGCCCGAAGTAGTAGTACACCGCGGTGTACGGCGGGAAGTCGTGCGGCAGGTAACGCCACTGGCAGCCGACCCGGGCCTGATACAGGATCGCGTTCACGATCTCCCGCATCTCGTATCGGCCCTGATGACCGCTGACCGAGCGGTGCTGTCCCTTCCAGGCCGTGATGACCGGCCGGATCAACTCCCATGCCTCATCCGACAGATCACTCGGGTACGGCTGCCGCTCAGCCACGTCTCCAGCACACCGCAGAAGCCGTCAACCGCAACCCCTCAAACCGGACAACCAGACACGACGACTCGCAGAACACCCACTGACATCGTCGCGTTCGACAGCCATGCGCCGACAGCTATCGCGCTCCGAGCCTGCTCTCCGTGCGGCGCGCCCTGTCCGAGGCCTGCCGATGTACACGGGCCACCCGGTCGGGTGAAGACACCCCGCGAGCAGAACCCTGGCCGGCGCCAACCCGTCGTACCGGGCATGAGGCAGATCAAGAAGCAGCACCTGAAAGAGCCCGGGCTCGCCATGGTGGAAATCGCGGCCGCGGACACGGCGACCGCACTCGCCGTCCAGGCCACGCTCGCCGGACGGTGGGCGACGTCAGTGACCAACCCCTACCGGGAACCCGGCGAACCCGGCGTGCGGCTGACCTGTTACCTCGACATCCGCCAGGACAACGACACCTAGGCAGCCCTAGCCCCGCACCTCCACACCCACCCGTGGTCGGCCTCATGGTCGGGGCAGACCACGGGTGGCGCGCCCCGACCATGAGGCCGACCACGTCAACGCACCGCTGATCGAGAACGCCCGTACGCGCCAGCGCGTCATGCCGTACATCAACCAGGCACATACGGCGCTACCGGGCCTGGCCGTGGTGGAGATCGCGGCCGCCGATGACACGACCGCCTTCGCCATCCAAGAGCTGCTCGCCGCGCGGTGCGCCCCACCGGGGTGCTTGCCAGGTCAGTGGAAGCACGGCGACGCCGTCGCCGTAGGGCGGGACACCGATTCCACGGGTCACCGCGACCGCGTAGCTGCCCACCCACGCCGAGGACAGGTGCGTTACGAAATTCGAAGGAACCCCACCCATGCAGCCGGATCACAACTGCCCTGCGGTTTTCCGGGGGTTGACCCTGTTGCGGCGACTCTGACAAGATGAGATTGAGGGCAACACGCGTGTGCCCTCACATGCTGAGGCTCTTCTTCCAGTGGCGAAGACGGGCCTTTTTTGTTTCTTCGACCAGCCCCTGGGTGACCCCAGGGGCTTTTTTCGTACCTGGAGGTACCGTTGCCCACCCCGTCCGCCGCCCTGCTGGGCATGCCCATCTGGCTGGCAGTGCTGGCCGCGTTGCTCCTCGTGGCCCTGCTCGGCATGGTGGTCTGCATGGCCTGGCTGATTGCGCGACGGACCCCGTCCGCCGACCTACCGCAGGTTCTGCTTGGGCTCAGTCACGTCATTTCCGCGCTCTGCGGCCTGCTGCCCTGGGGCAAGCCCTCGGCGCCACTGGCCCTCCAGACGCCCCCGGTTGTGGAGCAGGAACCCGCTGCAGTGCCGACCGTGGTCGTCGTGCGGAGCGAGACCGCGCTGCGGTCTGCCAGGTCAGGGCACGAGGGATGAGTCGGCGGCCCCGAGCCAGCGGGCAACACCGGCCCCGCGTGGAGCGCACCGCCTCGCTGACTTACCTCCTCCGCTCTCTCGACCACGAGACGGCGGTCCTACTCCTCGCCTACGCGCTGTATGGCGCGAACCGTGCAGACCTGGCTCGGGGGCTGGGAGGGATCAACGAGTGGCTCGCCCATTTCAAGTCTCAGACTGCGCTGTTTCAAGCACGCCTGCCGAGGAACCACAGCAGCGCCCGGGAACTCTGGTACACGGACGATGGAAACTCCCTTGTCATCGACGAGGAATTGCGGGCCCTGATCCGCGAATGGAAGATCGAGGAACGGTTCGCGCCCCACTGCCGACAGTGTCGCGTGGTCTTCGAGCGTCCCAAGAGCGCTCGGCGACCGCGCGAGTACTGCTCCAACGCGTGCCGTCAGAAGGCATATCGCGCCCGCCGGAAGGCGGCGCGCTCAGGAGACGGCGACCGCGGGTGAGCCCCGAGAGAGCAGGTGGAGGTCAACGTGATGCAGGCAGGCTCTCGCGAGCGTTCGGTGTTCTGAAGTCTTCCCGCAGATAACGCCCTATCATCTGCGGCATCGCCGATCACGACCTGCGGCGACTCCGCGGGGCCGTGTGCGAAGCGACCCTGTTATCTGTGGCAAGGGAGAAGCGGTGCCCGCCGTCTGCTCGCCCCCGGCGACAGCACGCGCTGAGACACTCTCCGGACGGCCTCGGCAAACGCCAAAGCCGTCCCGGTGGCACGGGGGGGAAACCACCGAGACGGCCGTGCTCAGCGTAAACACCGAAGGGCCCTACAAGGCCACACCCCTGAGCCGCACAATCAGGGGCACCATCCGCCATCGCTAGCCAGGGGGCAGGAATTGAGACGTACGAGGACAGTGGCTGTCGCCCTGTTGATGTTGGCAGCAGCGGGTTGCTCGTCAGGGCTCCAGGGGGCCGAAGAAGGAGACTGCTCCGACTACGTGGGAACACTCAAGGCTTATGCCGGAACGCTGTCTCGCTACCATGACTCGGCGACTGCGCTTGAAGAAGACATCAACGGTGGATACGACCCTGCTGGCGCAGTCGCGGCGTACGAGGGCCGACTCCAGAACGACTCAGCGACACACGCAAATGTCGAGAGGTGGGCAGACGAGCTCTACGGCACCAAGTGGGACTGCCAGTGGGCTCATGATGGCGTCGACGGGCTTCCGGGCTGAGACCTCGCACGGGCAGGCCCCGCACCCAAGGGCCGGTTCGCTCCCCCAGCCATGCAGTACGAGGGAAGCGATCACCGCGGGTCGGGAACGGTCACGTTGTAGGTGACCGTCCACGGCTGATGTCCCTCGCGATGGCGGCGCACCCACAGCCGCACCGCGGCCCCGGGCAGTGGAGCGCTCGGGGCCGCGTACGCAGAGTGTGGAGGTGAAGGGCGGTCGCCTACGCGGCGAAAGGCACTGCAGGGCTTCAGCCGAACGATCGTCCCTGCAGGCAATAGGTGAGGCCCGGGGACACTGTCCCCTTCACAACCACGTCCCTCACAACCTGCCCGGCCGGGCAGACATTCCCGCCCTCGCTACCGAGGGACGGCACGCCGGGATCAGGCGCTGCGCGGCTTGCGGCCGGCGCTCTTCTTCGCAGTCTTACGGGCGGTCGTCTTCTTCGCGGTCTTCGCTGCCGTCTTCTTCGCCGTGCTCTTCGTGGCTGCCGTCTTCTTCGCGGCGGTCTTCTTCCTGGTGGTCTTCTTGGCCTGGGTCAGATCGTGGACGTCGGCGTCGCCCGCCTCGCCGCGGGAGGCCTTGGCCTTCTGCACGGACTCCGTCAGGGCAGCCATCAGGTCCAGTACCTTGCCCGGCTTCCCCGACTCCGGGGCCTCGGGAAGGGGTTTCTCCTCGCGCTTCGCTTCGATGATCTTCGCCATGGCGTCGGTGTAGGCGTCCGCAAACTCTGGGCCTTCGAGGTCGTCGCGGCTCATCGACTCCATCAGCGCCAGCGCACCCTCGATCTCGTCGTCGGACACCTCCGTGGGCGGCGGCAGCAGCTCAGCCGGGCTGCGGACCTCATCCGGCCAGCGCATCGCATGCAGCACGATCACATCGTCCCGGACCCGCAGCAGGCCCAGCCGCTCGCGGCCCGACCAGGCGTACTTCGCGACGGCCACCTTCGACGACCGGCCGAGCGCCTGCACCAGCAGCCGGTACGGCTTCGCCGCGACCTGCCCGTCCGGCGCCAGGTAGTAGCCCTCCGCGATGCGGATCGGGTCGATGCTGTCGAGCGGCACGAACGCCTCGATCTCGATGGCCTTCGCGGTCGGCAGCGGAAGCTCACGCAGCTCCTCATCGGTGATCGGGACGACTTCTTGGTCTTGTGCGTACTCGTAGCCCTTGCCGATCTCAGACTGGCTGACCTCACGGTCCTCCAGCTCGCACACCTTCTTCACCCGTACCCGGCCCATGTCCTCCAGGTGGTACTGGTGGAAGCGGATGCTGTGATCTTCCGTCGCGGACTGAACATGCACAGGAACGGTCACCAGACCGAAGCTGATGGCACCTGACCAGATGGTTCGGGGCATGACTGACCTCCGCACAAACCCCGAGCACCAGCAGGTGTGGGATCTCAGATTCCGTGGCCGAATCTCACGACCGATGGCCACTCGATGGCCGGGCGGCCACCAATCTGAGACCCGCAGGTCGAAGCGCTCACCCTGGAGGCTGACGAAGTGCCCAGTCGCGGTCGCCCGGCGTCGGCTCGGTTCGCCAACGAGCCCGTAGGACTCCGTCGTTGTCGGGCATGACAGCAGTGCACAGAGGCACAGATTCACCCGCATATACAGACAGGAACGCGGCGGCATGAGCACGGGATATCCGGGCGGCCAGTTCGGGGAACTCGTCCTCTTCGGCGATGGCGCTGCGGATGTTGCCGTCGTCGTCCTGCCACACGCCTTCGACGAGGCCATCAGCGGGCAGGGCTCTCAGGACGGCGTCGATGTTGGTGGACAGGGGCGGCCAGACGGCGAGACGGGCCCGGGGAGCCAGTCCAGCGCGAACGGGGTCGATGGTGTCGCTGGTGAGGTGGTGCCATCGTGAGGCACCTTCGAGATACGTCTCTTCCAGAATTCCTGCTTGGCCGGTGACGACTGCCCAGTACAGGTCGGCCCAGAAGTCGTCATCGCCGGGACGCTGGATGACCTGCTCTTCCTCCTCGGCCTCGAAGGCGTACGGGGAGGCGTCCAGGCGTTCTGGGAAGAGTCCGAGCTCCCGGGTGTGGGCCAACGCTTCCTCGCAAGGCCGACTGCTGCTGATGTAGAGGTACTGGTCCCATCCCACATGGACCGCGAACGCGCCTTCCGCCTCCAGCCGACACCAGGCTCCGTATTCGCGCAACATGGCTCGCACCAGCTGCAGCCCGATATCGAGCGGTACTTCTGCCCCGTCGTGAAAACCGGTAAGGCCGCCAGGGAAGAGCCCGTCCAACCCAAAGCCGTCCACCGGAGGCTCCACACCGAAGTGCGCCAAGGACGGGACCTGTGGTTCACGTACGGCCAGGTGATCGACGCCGCTGTCCCCGGCGAAGGCCGCGACCGCCTGAAGATAAGACGCCTCGACCTCGCCGTGATCGCTGACGGTGTCCTCACTGCCCGTGTAATGCCCGTGTTCGTCACGGTCGGCAGGGTCGTACTTGGTGACGCGGTAGACGTAGGGGAGCTGCACCGCCCCATCATCCAGCACGCTTGTGTCGCCCCCCGAGGAAATGTCATGGGAGGTGAGACAGAGGCGTAGGCCAATATCTTGAGACAGATCAGGAACCTGCTCGTCAGCGCAATGCTCTGTGACACGAGCCGCGAGATCCTACAGCAGGCTATGACCGGCCCACCCGTTGCGCACGCGGGAGCGCCCGCCGGGTATGCGATCGCCTCGACAGGGACGTCGATGGTCGGGCTCCTGGTCGGCCGCCGCTGCACCCGGCCCCGCGGTGCGCCCTCTTGTACGAGGCACCCCACAACGGAGTGATCTTGGATCGCAGGCCGTGACGGGCCAGGAGATCACGACAGTTTGCACGATTATGAACCGATTCATGACCATGACCGCGATCACGGCCATCCTCGCCGGCCTCGCCGTTGCTCCACAGGCCGCCGCCGCACCCCCGCAGAAGACGACCGCCGCACCGTGCACCACGCAGTGGGAGGTCACGGGCAAGACGGTGGCCGTACGGCGCCCGGCGAGCGGAGGGCGACCGCGTGACCTCCTGCGTCACCGCCATCGCCAGAACCGAGAGCGGACCCGCCTACCACAAGTGCGGCCGCGACGGACACCTGTGGCAGATCGTCCGAGGCGGACAGGTCCCCCAGACCTGCCTGAAGAAGGTCAACCACTAGGCCGGTCAAGCCCCCCCCCGGGGGGGGCGATGAGCCGTAGAACGCAGCGCCTACCCCCGAGAGCCGGGGACGGGCGCTGTTTCCACCATCAGTGCGCCGTTGTCTGTTGCGCCGATGGGCACGTGTTCAGTACCGCTTTCGACGATGTTCGTCATCGGGGACGGCAACCTGCTGCCCATGGAGAAGGAGCAGGACAAGATCCGGATGACCGACGGCGCTTACCTCAAGGACGACGACCTGTCTTCAACAAGGAATACGAGGTCCACGCGTACGTGAACTGCATGCTGGTCGACTTCTTCGCCGCAGATGAACGCGACCACGACTGCGAGGCCGACGGCTACAGCGACACGCCGCATGGACTCACGAAGTGTGATTCGGAGCACACGGTCCTGCTCCTCTGCGACAGGCCCAAATGCCCCTGACCAGCGGTTTTTGGAAAAGCGCCGGACGTAGGCAAGAGGTTGAGCAACACGCTACCTGAACGCCGAAATCCACGTTTCCGGGCGTCGCGATAGTCCGATTAGCCCGAATACAGGTCGTGTCCGGTGTAAGTCCCCACCAGTACGGTTGTCGCTACCGAAAACCCCTTCGGAGGCATGACGAAGGGAGACCCCTGCGCGGTCCGTGCTTTGGCGGGCCTGGCCACGCGGGGATCTCCCTCTCGTGTCGTCAACGGCTTGTCCGCTGTTAGGAGACCAACCGGATGACGCTTCACGAACGTACCCCAGGCGAGACCCCGCCGCCCAGCTCCGCATGGCTCACGCGGCTGACCGCCCTGACCGGACTCGTCTCCATCATCGGGATCGTGGTCCTGTCCCTGACCCACAACACCGAGGCCGCAGCCACCGTCGGCGCCATCGGCACGGCAGTAACGGCTCTGGGCGGCGTGCAGATCGGCGTGCGCAACCGCCAGTGATGGGGCTCTTGCCCGGCCCTGGGCATCCTTCGCCTCCCATGCAATCGTTCCCGAGCATCCGCGAATCCTGAAGGGCAGCACACCGCGGGTGTACGGGAACGGACCGGTTGCTGAGGCACCCTCTCCCGACAGACAACCAACTGCCATGCTGAGCCGCCGAACGCACACCTCACCCCACCTTTGGAGAGCAGTGTGGAACTGAGCGCCACCGGCGAACCCGCCGTCGTGCAGGAAGACACCCATGTCCACGTCGGCCTGGATCTCCGGCCGGGCAGCCTCACCCTCATCCGGGACGGAGAGGACTTCGAGCCGTACCGCGCCGTGGTGCAGTTCGTCGGCGTCCACGACAACCCGTGGGCAGCGCAGGAGGTCAAGTTTTCAGCGACGGGACCGGACGGCAAGAACGTGGGGTTGACCGTGGATCTCCTCAATGACTCCTGGGACGGGCCCCGGGACGATGTTCCCGAGGCGATCTGGAAGGTGGTGGCCCTGGCCGCGACGTCCGCCGGGGACATCGGCATCACCTATACAGCTCCTGGCCCAACCTGAGGCAGATGCGCGCTGTCGAGAATTACGTACATTGCCGCCAGCTCCTTCTGGACAGCGGCGACGGGATCGCTGGCGACGATCTTCGGGATGCCGAGCACGCAGCCTGTGATCGCCAGAACTTCCGGGACGCCGGCCTCTCCCCATCGGTCGGGCTCATCGCAGTCCGCCGGGTCCAGGCTGCTCGTGGCCTCCTCGACAGCGTCGGCCAGATCTCCTGTGATCCAGTTCCCGGTCGCCGGGCCAGGCAGGAACGAAGCCAGTTCGCCGCCCGCAGGTCGGCGGCGGCAGTCGCTTCAAGAGCCGCGGTCTCGCTGGGGATGGGCTCACGGGGCGGCCGACCAGGCTGCTAGACCGCGGCGGGACGGGAAATCTGGTAGTACGTCCCGTCTGGCAGAACGCCCCTCTGCGACCAGCGACACGTCCCCAGCCCGCACGTGCTCAGGCCGTGTCGGCGTAGGGCACAGCCCACGCGCCGCTCGTGGTGGACACTTCGAAGGGCAGGCGCCACGGCTTATGCCCTTCAGCTTCGCAGTCGGCCCACAACCGCAGGGGACGCTGGTAGCGGTAGTCGGCTTCCCATCGCAACTCGCCGGACGCGCCCTCGTACCAGCGCGGCCGCATGCTGGGTTGGACAGTGACCTTCCGCTCGTCGTGAGCCTCCAGGTGGAAAGGCCCAGCGGTTCGCTCTCCTGCGTCGGCCCGGTCGACCCCTTGACGGAACCTCAGCGGGCCCCAGATCACTGCGGCGCGCTCGGCTCGCTGTTCCTCGGGGTCCGCGCCAAGGACCGGGTCATCGGAGTGGTCGCGGTCGTCGCGGATGCTCAGGCGGACCTGAAGGCGTCCCAGCTCCCCTGGTCCCTCGAATCGCAGAACGAGCACGTGATTGGGCTCGGAAAGGTCAACGCGTACTCGGAGGCGGGGGGTCAGTTCGCGGTGCCAGCGGTCCCGCTCGATCTGGGCCACCGACTCGGCAGTCTGAGCAGCCAGTTCGGCCGTCCGATTCGCCGTCTGCCCGTTGTGGTCTGACGACTCGGCAGCCTTCTTAGCTGTCTTCGCGGCGTCCATGGCGCTGTACGCAGCCCAGCCCGTGAAGAGCGCGGCAGCAGCCGCGAGGCTGCCCTCAACAAGGTCCATGCGCGGCATTCAACCTGCACTGCGGACATGGCGCGCCGATTTGCCGAATCCGACGAAGCGGGCAGCGCCCTCCACGCCATCTGTGCAGCCGTCCGGGGGGCCTGTGCCAAAGATGCTCATGACGGTGGAAGTCGTTGACCATGTCCTCGCCTACGCCCGACTGGTCTCTGGCCGAACCGATGCGCGCCGTACCGGTCAACGATCCGGCTTTGCCTTCCGGGTGCGCGGCACAGGTCAAGTGGGATGGCTATCGCGCCCTCGCGGGGCGGTGGGCCGACGGCCATATCGCCGTACGGAGCCGTAACGGCCGGGACCTGGCCGCCCCGTTCCCGGAGATCGCGCACGCGGTGGAGCAGCTGCCCGTCGACACGGCCGTCGACTGCGAACTGGTGGTGTGGGAGGCGGGTCGGCTGGCGTTCGAGCGTCTCCAGCAGCGCATGCACCGCCGCGGCGCGGGTGCGGCCCGGGCGGCGGAGAAGTGGCCGGCGCACCTGGTGGCGTTCGATGTCCTGCGTCTGCACGGACGGGATCTGACCAGCCGTCCGCTCGCTGAGCGTCTGATCGCGCTGGAGGAACTGTTCCGCGAGCACGCCCTGGCGGCGCCGTGGTCGCTGTGCCCGACCACGACTGACCCCGAGCAGGCTGCCGCCTGGCTTGTAGTGCTCGTAAGGCGCCCTCATTTCCCACGCGTGCTCGTACGCGTCTTCGGCCGCTCGGCGAGAGACCGGGTTCCGTCGAACGCTGCAGCCCGGTCATCGGTTGAGCTGACGGGTGGGCCATTGCGCGCCAACATGCTGAACTTGACAGAGAATCCGCCGAGTGGGGCTCCCGGGAGCACTTGTCGGTGCTCCTGGTCGTGCCCGAGGTCATCGCCGAAGTCGCCGTGGACGTTGCCCGGGACAGCGCCGGGCGCTGGCGCCACCCGACACGGCTCACACGTATCCGCACCGACATGGAGCCCGGCGAGGTGCCGCGGTTCGGGACGGCCCTCTAGCGGGTCAGCGGCAGGTGTTCCAGTTGCGCCCGTCGTGTACCAAGGCGCCGCTGCGTTCCAGGACGCGCGGATCGCTGGACCGGCAGCTGGACGGCTGGCACTCCGCCCGAGTGTCAGCCGGACCCTTCGTAGCCCGGATCCGAGCAGCGCACGGCCGCCCGGACGCGATCGAGTGACAGAGATGATGCGGGAACTCTCACTGGCGCGCCATCGGTGCGCTCACCAGATGGTCGCCTGCTCCGCGGCGGGCTGGTAAGCCAGACCGCGGAATACCGGTGGCACCGTCGCGGAACGAGGCGCGTGATCATGCCGATGCCCAGGACCGGGACCGGGACCTCCATGGGCATGATGGCTGTGCGCGGCGACGTATCCGCCGTGCTCGTCCCGCTCGTACACGCCGTTCGCAAAGAGACGGGCGGCCCGCTCCCGCAGAGCAGAGAAACTGGCCGGTACGTCCTCCAGCAACGGGAATCCGACGGGGCTCTGCTGCAGCCACGCATGACAGATCACCGTCAGGATGTCGGCACACGGCCCGGTGACCTCCTCATGGACCACGGCATACAGCGACGCGATCAGATCAAAGACGGTGTCCTCGTCCTCCACGCGCATCCGTGCAGTGGGCGGGTACATCCGGCCCCCGATCACGGCTGGCTTGTCCCGGAACACCATCGGTTTCGGCACCACCCCGTGCGCGTTGCACTCATGAACGGCCGTAGACTTCGGCTTCCTGTTGACCACACGCCCAACTGAGGTCCCGGCGCCCGGGGAACGGCACCGTCGTCCCAGTTCACTCCAACAGCACGGCGATATACGCCATCCCCACCGCCCTGGGCCGCAACTGCCGCTCACCGCTTCACTCCGCCGTTGCCGTGCCACGATCGCGTACCGAGGAGCGGGGCGCGCGGGATCCGCCGCACCATCCCGTCCTCAAGAAACGCGGCTCGTGTGGCAGCCGGCCACCGAAGTTCGACCGCAGAACTACAAGACTCAGCCCGCCGCACAACGCCGTTTCCGTCCAGCGCACCGGTCCTTGAAGGTCTACGCTCACGACGCGAACCCGCGGGCCGCCCGCAGGATGTCACTTGGAGCGGTCCCGCACTGGGCCCATGCGATACCGACACCTGCGCGCATCTGCACGGTCTGGTTGCCCAGGGGGATCGGCAGGTGGATCTGGGACTGCATCCACACCGCGGCGCTGTGCGCATCGGCGGGACCGAAGCCGTCGGCGAGGACGACGAACTCGTCACCGCCATACCGGGCGACCGTGTCGCCGTCGCGTACGGCCTTACTGAGCCGCCGGGCGACCTCGACGAGGACTCTGTCCCCCGCGTCGTGCCCGAAGCGGGTGTTGATCGCCTTGAAGTCGCGGAGGGCGAGGAACACCACGGCCAGGCCATGGGTGTTGTCGTCGCCCACAGGGGCCAATACGTGGATGTGGGGGGACGCGGCCTGGTCGGCGTGGCGGAGGTGGGGGTCGTCGACCCGCTCCGCAGCAGTGTCGGACCCGTGGCCCCGGTATGCGCAGAGCCTGGCGTCAATACGGGCGTGCAACTCGGCGGAGTTCGGCAGGCCGGTGAGGGAGTCGTGGGAGGCGCGGTGGGCGAGCCGGAGCTCGCGGCGCTTGCGGTCCTCTATCTCCTCGACGTGAATGAGCAAGAAGCGGGGGCCATCGGCGGCGTCCGCGACCACGCTGTTGCGCAGCGAGACCCACAGATACGTCCCGTCGCGGCGCCCGAGGCGTAGTTCCGCGCGCCCGCCCTCGGCGCTGGTGCGGAGCAGGATGGCCATGTCCTCGGGGTGGACGAAATCAGAGAACGAATAGCGGCGCATGGCAGAGGCGGGGCGGCCGAGCATGCGGCACAGTGCGTCGTTCGTCCGGAGGATGCTGCCGTGGCGGCCGCCGTCCATCTCGGCGATGGCCATACCGTTGGGCCCGTACTCGAAGGCCTGCCGGAAGGATTCCTCGCTGGCCCGCAGCGCCTGCTGCTCCCTTTCGAGCCTGACCAGTGCCCGCTGCATATTCGAGCGTAGCCGCGCGTTGCTGATCGCGATGGCGGCCTGGAAGGCGTACTCCTCCAAATCCCGGCGCTCGTCCGGCCGGGGACGACGGCGGGTGAGGGGTTGGTCCACGGAAATCACACCGAGCAGCTCACGGTGGGCGGCGCCGGGAGCGCTCCGGGTGTACATCGGCGCGAAGAGGCGGTCGGAGGGGTGCCACTCGTCCTCGAAGCGGGGTACGGGGCCGTCGGTGTACCACTGCGGTACGTCGTCGTCGTCGAGGACCCAGCCCTCGGTGTGCGGGATGAAGACCAGGTCTCCCCAGTTCTCACCCATGCTCAGCCGGCGCTCCCAGGAGTCACGGGAGCCGACCCGGCCAGTGATCTGTGCCTCGGCGGCGGGGTTGCCCGCGAAAGAGGCGACCACGAGATCGCCGTCCGGGCGGACGAGGTTGACGGATGCCAGCTCGTACCCGAGACCGGCCACAACTCCGTGGGCGACGACCTTCAGGGTGTCCGCGAGATTGTGGGCGAGATGGAGACCCTGGACCGCGGCCCGCAGACTGTGAATCTTGTCGATGGCGAGCGCGCTGCCGGTGGCGAACTCGGCAGCAACCGACAGATCGGCGTCCTGGAAGGGCTGCTCGGTGGGGTGCCGCAGGAGGACCGCCGTGCCGATGATCCGCCTGCGACCGTGCAGGGGCACAAGAACGGTGTGGCCTCCGCCAGGTGCCTTATGCCCCTCGCCGAGCAGTTCCAGCAGTGCGGTGTCACCGACCGGCGAGTCGGTGGTGACCGGCAGTGCCCCGTTCAGTACTTCGAAGAGCGCGCTGTCGGGGCGTACCTCGCACTGCGCGGCACCCCCTCCGGCATGGAGCGGCTGCACTTGTTGCAGCCGGAGCACCAGCGGGCCCGCGTGTTCTTCGTCGTCCACCGGGAGCGGGTCCCGCAGGTAGACCATGACCGCGTCAGCGACGGTGGGGACGGCGGCCCGGCGCAGCCGCGTCACGATGTCCTCCGGGTCCCTTCCCCAGGTGATCCGCCGGGCGGCCTCGGAGATGTCGCCCTGGGGGTCGGCGGCCGGAGGCCGTGGGGATTCGAGCGCGGGGAAGGTTGTGTCCTGGCTGGTCGGCGGGTTGTTCGGGGTTGTTCCGGACGACCCGAAGGGTTGTCCCCCTGGGTTCTGCCGAATGTGTCCGGGCGCTAAGACGCTGGCTTGCGCCGGAGAAGCAGGGGGACTTGAGGACGACCAGTAACCCACCTCGTCGGCGGCCTGCTGAACGGCTTCGTGCTCCTGGTCGAGGACGGCGCGCGCCTTCTCCAGCGCACGGTCCACGTCGTTGAGCGCAGCGTCGTCCGGGCTGAGTGCGTGCAGATCGGGCCGGGACAGCAGCGGGGCTGGCTCCTGCGTCCGGGATGGCCCGTCCTCCCCCATTCGGTGCCGCAACTGGGCTAGTTCGGCCTCCAGTTCATCGATACGGCGTGCCGCGTGGTCGGCGACCTGCTGGGCGATATCCCGCTCCCGCTCGGCGCGAATCAGCTGTTCACTTAGTTCCGTCTCCTGCCGTTGCGCTCGGAAGAGAAGCTCCACCACCCCTTGACCGCCAGGGAGGTGGACCGCCACCGACTCCAGCGCGTCAAGCCGACGCCTCAATTCGGCGACCTTCGCCTGGGCCTGTCCGAGCATGACGAACAGCAACGTGGCGATTGACAGGGCCTGTTGCCGCCCGTGCTCGCCAGCCTCGTAGGCCTGCCGGGCGCGCTGCATCTCCTGGAGAACCTCGATGATGCGGTCCTTGGCCTCCAGCAACTCCCGGGCAGGCACCAGCTCCTGCGCCTCCGTGATCGCTGTGGGGTTCGTGCCCGCCCGATCCCACAGCATCCTCGCCTCCTCGAGGCGCTGCCGGGAGAGGCCGGCCTGTTCGTGGGGAAAACACACGTCGGCCACGGCCTCGACGAGATCCCACGCCAGCGACTCACCGGACAGCCGGTCGCGCAACCGGCGTAACTCGGGCACGGCGCCGGCGATGAAGTGCTCGGGAGTGAGCCGTGCGTGCAGCTCCCGTACAGACACCGCTGATTCATCGAGCCAGGAGCGCACCACCGCGACCAGCTGATTGATCTCGACGCACGAGCCCCGGGCCGGTCCCCACGGGCGCCCCGCTCGCTTCCTCTCGCCGGCCACTCGTTCTCCCCCATGGTTTGTTCGCCGGACAACCCTCTGTTGTTACCGGAGAATCATCCAACCGCCCCACCTGCGATTCCGCGCAGGGATCGTCGTAATTCGTCATCGACACCACACGACCCAGGCGGTGCCTTCATGAAACACACCCTCCCGGCGTTCCTGCTCCTCGCGCTGGCGGTGGCCGTCCTCTTCTCCGTCGTCGCTGCGGCGATCGCCTTCGCCCTCGCCCGCTGGGAGGGAGCCGCCGTGCCGTCGGCCCTGTCCCGCTGCGGCATCGCGTTCGCCGCCAGCCTCACCCTGTGCCTCGCCATCTTCTCGGCGCTGGACCGGACGTGACCGGAGCGGTCAAGGGAGTTCGTCGTTGTCTCTGACCCTTGTAGTGGCACTCGCCGGCCTGCCGGGGAGCAGCCGGGTCATGGTCTCGGCGGCGCGTACGGCAGCGTCCCCACAGCAGTTGTCGAACAGGACGTGGACGCGCTCGGCCCGCTCGGCGAGGGCGTGCAGCCGTGGCAGCACCATTCGGTGAGCTCGTCCCGGTCGTACGAGTACCGGAACCGCTCCTCCTTGTTCCCGGGCCTCCAGGACTCGCTGCGCCCGTGGAACCGTACGACGGAGAGCCGGGAGGACGGGAGTGCCGGGTTCATGTCGACGGTGGCGGCGGCCATGCCGTACCGCGCGAGCAGCGTGCACGTGGCCGACACCAGCTCGCTCATCCGCGCATCGTAGTGCGGGTATTGGCCGGGATGTCCGGCTCATCGGCGGCTACTGACTCCACAGCGTCCGACGATCCAGAAGGTCCCTTTCTCTCCGATTCCCATTCTCGTCAAACTGACGGTAAGATTGGATGCGGAGAGGCCGCCCCGTGCGACCGACACCCGGTCATGCCGTCGCACCCGGAGGCCAGTTGTGGAGCCCTACGTCAAGCTCGCGTTCACCATGCGCGACACCCCCGGCGCGTACGCGGTCCTGCTCGGGGCCGGCGCCTCGATCGCTGCGGGCATGCCGTCGGCGTGGGACGTCCAAGAGGATCTCATCGCGCGCCTGGCGGCCACCGAGGGCTCCACCGGGATCGGGGACCCCCACGCCTGGTACCAGGAGCGCTTCAGCCACTCGGCTACCTACGACGATCTCCTGGCGGCGCTCACGAGCACCCCGTTCGAGCGGCAGGCGCTGCTGCGCTCCTACTTCGAGCCCGACGAGCAGGAGCGGGAGGACGGCCTCAAACAGCCCACCGCCGCGCACCGCGAGATCGCCCGTCTGGTTGCCGCGGGACACGTCCGCATCGTGCTGACGACGAACTTCGACCGGCTTGTTGAGACCGCGCTGCGTGAGGTCAACATCGAGCCCGTCGTCGTCGCCGACGCGGCCGACGCCGCCGGCCTCGCCCCGCTGCACACCATCAGGTGCCTCGTCGTCCATGTCCACGGCGACTACCTCACCCCGACGAGCATGCTCAACACCCCCGAGGAACTCGACCGCTACGCCGAGGACATCGACCGCCTGCTCGACCGCGTCTTCACCGACTACGGGCTGATCATCTCCGGCTGGTCCAGCACCTGGGACCCCGCCCTGCGCAACGCCATCGCCCGAAGCACCACCCGCTACTTCGCCTCCTACTGGACCGACCCCAGGCCGCTGTCGGAGACCGCCCAGAAACTTCTCACCCACCGCGCCTTCACCTACGTCCAGGCCGACGCCGACACCTTCTTCACCCGGACCGCCGACGCAGCCGACGCGGTCACCGACACCAAGCGCCGGCACCCCGCGAGCATCGACATCGCCGTGGCCGCCGCCAAGCGCGCCCTGGACGGCTTCAGCCAGGGCATCACCCTGCACGACACCCTCCGCCGCGAGATCGACCGCATCGCCGCCCTCCCCCTGCGCACCACCGGCCCGTGGAACGTCGGGAACCGCGCCGAGACCGATGCCGAGCACGGCCGACGGCTCAACACCCTGGAAACCGAGATGGAACTCCTGCTCACCCTGGTCGCCGTCACCGCCTACTGGGGGAACAACACGACCGACCGCTGGTGGCTGCGCGACATCGAACAGCTCGGCGCACTCCACGATCCCGGCGGCGACCTCGGCCTGATGAAACTCGTCAGGGCCCCCGCCACCATGATGATCTACGCGGCGGGTATCGCCGCACTGGCCAACGAGCGCTGGGACACTCTCGCCCACGTTCTCACCGAGCCCCGAGTCGAGCAGCGGATCAACGGGAAGACCTACGCCGCGGCCGCCCTCCTGAGCCCGTGGGAGACCCTCAACGTCAACGGCTCCTCCAAGCGCGTTCACGACCAGCTGCGCCCCGTCTTCACCCAGCACCTCGCCCTCAGCGAGACCGCCTACGGCGAGGCGTGGGAACGCTTCGAGTATTTGCGCGTGCTCGTCGAGGACGATGCCGATCTGGCCTTCAGCCTGCCGCACATCAGCCCGACCGGCTACCTCGGCACCTTCGACCCCGCCCCCGCCGCCTGGCTGAAGAAGCAGATCGACCAGTACGGCGACAACATCCCCGTACTCCGCGAAGGCCTCCTCGACGGCAGCCGCCAACGGCTCGACCAGGCAGTCACCCGCGTCGAGAAATCCTTCAACTACATGGCCCAACAGATGCGCTACGCGTAGCCGAACGCGGACGCAGTCACGGCACCTCCCCGGCAGCCGGCGGGAGGTACGCCCCCGCCGTCATCGTGCCGGTGATCACCCGCGAGGCAGCCCCCGAGCCCTACCAGCAGGCTGCGACGCCACCGCGGCGGTCGAGGTCGTCAACGGGCGCGGCGGGGATGGCGGGATCGACATCAAGGTCACCACGGGATCGGCGGCCGCGGGGCGGGTCTGCGGATGCGAACGGTCGGCACCGAGCTCGCGGTGCGCCTCACCGAGACGGTGCGGCGCCTGGACCTCGACAACCGGGAGCTGCCGGTCGATCGCGGCCAAGACGAAGAGGAGGTCCTGGCCCGCATGCTCATCGCGGCAGCCTGGTACCAGGCCCTCGCCCGTACGCCGATCGGCTTCGCCTTCACCCTCACGCGGCTCCTGAAGCTCCCGCACCGCGACCTGGTCGCCGACGTCACCGCAACGACGCGCCCTCGCCAAAGTCACCGCCTTTGGGGCAGCGATCGATCAAAGATTCAAAGATGGTTCTCAGCGCGTCAGCATGCTGGTCCGCCGAAGAAGCCGTCCTCGCCGTCGCTGCCGTCACAGCCGCTGCCCCCGTCCGTGACGAAGCCGGTCCTAGACGTCCTGCCGTGCGATACGAGTAAGACCGTGTCCTACGTGGTGAGGCGGACGAGCCGCTTGTAGCAGCAGATGGCTGCGGCGAGCCCGAGGAAGGCCAGGTAGTTACGGGGATTTCGCTCGTAGCGGGGGCTGAGTCTGCGGTAGCCGGACAGCCACGACATGGTGCGCTCGATCACCCACCTGCGCCGCCCTAATCGTTCGCTGGACTCGATGCCTTTGCGGGCGATGCGCACGCCTATGCGTTTCCATCGGAGCCATCTGCGCAGGTCGGCACGGTCGTAAGCTTTGTCTGCGTGTAGACGCTGGGGCTTGAAGTACCGGCCGTTGCAGGGGTCGTGTCTCGTTTGGTGACCCTCGATCATGGGCTTCAGCCCTTCGCTGTCGTGGGTGTTGCCGACTGAGATGCCGACGAGAAGGGGCAGTCCGTTCGCGTCCGACAGGACGTGCATCTTGGAACCCGGTTTGCCTCGGTCCACGGGGCTCGGACCTGTGTGTTCGCCCCCTTTTTAGCCCTGACGTGGGCCGTGTCGAGGACGACGCGGGTGACGTCGATGAGGCCGGCGTCGTCGAGGCGGTGCAGTACGGCTTCGTGCAGGCGGCCCCAGACGCCGGCTCTCGACCAGATCAGGAACCGGCGGTGGGCGGTCGACTTCGATATGCCGAAGCAGGGCGGCAGTTGGCGCCAGGCGCAGCCGCTGACCAGGACGTAGATGATGGCCGCGAACAGTGTCTCGTCAGGCGTGTCCTGCGTTCCGCCGCCCTGCGGCCGCACCCGTGACGGAGGGATCAGTGGCTTTGCGATCTCCCACAGCCCGTCCGGAACAATCCAACTCCATGTACCCCGCCCCATGAACGAATCAACGTCCGCCTCACCACGTAGGACACGGTCTAAGTGGGTGTTCTGTGAGCTTTCGTGGGGTCTCAGTCCGGGGATGGCGTTGGTTGCGGTAGCCGGAAGAGGCCGGGCTCCGGCTCGGTGAGAATGCCGCGGCTGACCAGGCGTTTCAGTTTCGCGCGGACGCCTTCGACATGCCGGGGTTCGGTGCCGGTGTCCAGGGCGATGCAGACGTCCTTGGGGCGCAGTCCGTCTGCGGTGTCTTCGAAGAGGGCGAGGATCTGACGGTAGGCCGAGGGCAGCGGAGCGAGGCCGCCGGGAAGGTCTGGTGCGATCTCCAGAATCGTCTCCCGGGTGATCCTCAGTCTCTCCAACGCCTTTTCGGCGGCCGCGAGTTGGGTGGTGAGCTCGGCGATCTGAGTGCGGAGTCTGTCCGCGAGGTCACGGCCGGCCGCCTCGCGGATCTCGAGCTGTTCCAGGAACTCCTGCATGCTCACGCTCACTCGTTCATGCCGGTCCGGGGGAAGCGGGTCGGCGGCGGTCCCGCCAGGTGGGAGTGGTCGTGGCGGTGAGCCGGTGGGTCATGACGTCGGTCATCGACCAGCGGATCCAGGACGCGGAACTGGCGGGCAGGGTCTCGTAGTCGCGGGCCAGGCGGCGGTGCAGCATGAGTGTGCCGAAGGTCTGCTCGACGATCCACCGCTTCGGTGACGGGGCGAACCCCTTCGCCTGCGGGTCACGCGATACCACCTCGACGTCGATGCCCAGCGACCTGCCGTGCTCGATGACGGCGTTCTTGAACCCGGCATCGACCCAGCTCTTCACCACGCCGGGGTTGTCGGCGGCCACCTTGTCCAGCAGCGTGATTCCGACGGCGTTGTCGTGCACGCTCGCGGCGACCACGATCACGGCGATGAGCAGACCGAGTACATCGGTGGCGATGCCCCGCTTGCGGCCCCGGCTCTTCTTGCCCGGGTCCAGCCCGGTCGTCTCCTTGGGGGCGTTGACCGAGGCGTGCACGGTCTGGGAGTCCATGACGACCGCGGACGGGTCCTCGCGCCGGCCCTTCGACTCGCGGACCTGCCAGCGCAGCAGATCGTGGATGGTCTGGTCGGTGCCGTCATCGCGCCACAGCCCGAAGTAGTAGTACACCGCGGTGTACGGCGGGAAGTCGTGCGGCAGGTAACGCCACTGGCAGCCGACCCGGGCCTGATACAGGATCGCGTTCACGATCTCCCGCATCTCGTATCGGCCCTGATGACCGCTGACCGAGCGGTGCTGTCCCTTCCAGGCCGTGATGACCGGCCGGATCAACTCCCATGCCTCATCCGACAGATCACTCGGGTACGGCTGCCGCTCAGCCACGTCTCCAGCACACCGCAGAAGCCGTCAACCGCAACCCCTCAAACCGGACAACCAGACACGACGACTCGCAGAACACCCACTCAGATAGGCCAGTCCCCCAAGCCGCTTGCGCGGCTGTCGGGGCGCACCCCATCACGGCCTCGGTGGAAGCACGGGCCGACGCTGCATTGAGAGTCTGAGCAGGTGTCACCGTGCTCACACCGCCTGATCGTTGACCAGGAATGAGAACAGCGTGGCGCGGTGCGAGGGGCAGAACTCTCACTGTTTTGTGAGAGATGCGAGAGCGCTTTACAGGCCGATCCAGGCAGCCATGTGGTTGAGGCTGTCCGGGGTCCGGCGGGACAGGTGCACCAGGCCGGTGATAGTCTCCCTCGCCGCCGGGTGATAGCGGGTCTGCTCCGGAGCAACGCGACGGGCTTCAAGCAGCGACATCAGCGCGCCGTCGGCGTGTCCCGTCTCCATCTGGGTGCGTGCCTGGTCGATCAGGAAATGAGCTCGCCGGGAAGTAGCCAGCTGCGGCGGCAGCTTCTTTCCGATCTTGTGGGCTTTGGTGAGGGCGTCGTCGTAGGCGTGCATCTCCACGGCCGCGGACATCTCGTGCAGGTCCACGTTGGTCGGGCCGAAGCTGAGCCAGTGGATCTCGCCGGCGTCACCGAGCTTTCCCGCGATGCGGCGCGCCTCGCCGATGTGGACCTGGACGGCGGCGGCGTCTTCAGCACGTGCGGAGATCACTGAGGCACCCAGGTGCAGCTGTCCTGTGACGGCCAACGCCTCGCGGGTCGTGCCGTCCTGGCCCACCACGCTCTGGCCAGAAGCGATCAGCCTCTGGCCGATCCGGTACTCGCCCTCGCGGAAGTAGACCAGGGCCCGCATGTACTGGCGCACCGCGGCCAGGCAGGGGTCGGAGGCCCGTTGCGCCGCCCAATCCATCCGGTCCAGGGCAACAGCCGACAGGTCGTAGTAGCCGAGCTTCACACTGATGTCGTGCGCGGTGCGGTAGCACGAGGCAAGGGCCTGCCACAACGCGGTCGAAGGCGTCGACCACGCCGTGTGCGTCAGCTCGGCAATGATGCCCGGAAGAGCGCGGGCAGCCGTCCGCAAGTGCGCGGCACGGACCTGTGCGCACAGTTGGTCCGCACCGGCGACGAGCTGGCCGGCCGGCCGTGCAGTCACGTCCGGGTTCGGGCCGAGGTCATACAGGTCGAGAGCTTCACGGATCGGCCGCACGAGTTCGGCCAGCCGGTCCCGCTGGAGCTGCGTCACGTACGGCTGGCCGGTCAGCACGGTCACGTCAATGTTGAGCGTCTTCGCACACGCCGCCACAAAGTCGGCCGTCGCCGGGCGCGCACCGCACTCCACCTGGGTGAGGTAGCTGTAGGAGTAGGGCAACCGGGCAGCGAACTGCCGCTGCGTGAGCCGGGCCAGCCTGCGCTGCTCCCTGATCCGTGCGCCCGTGTGGTTCTCGTCCGGTGTGGGCATTCTGCTCTCCGTTCAAAGCACCCACTGGGAACACTACCCGCGCCCGACTCCCCTCCGGGCGGGCACCGTTGCATGTGGTCGTATAGAGCCATGACGACGACTCGTGTGCTCTACCTGTTCGGCAGCGCCGCCCCTCCCGTCTTCGACGTCGCGCAGGTGATCCACAACGCGCACGAGCGCGGCTTCGACGTGTGCCTCGGTCTCACCCCCACCGCCGCACGCTGGCTGGCCCCGCAACTCGCCGAGCTGGAGCGCTTGACCGGGCATCCCGTGCGCAGCGAGTACAAGCTGCCCGGCGAACCGGACGTGTGGCCGACAGCGGACGTGATCGCGGTCGCGCCGGCCACCTTCAACACGATCAACTCATGGGCGCTCGGCCTCACCCACGACTTCGTGGTGGGCGTCGCCGCCGAAGCCATCGGCAAGAACATTCCGACCGTGACCATGCCCTGCGTCAACGCTGCATACGTACAGCATCACGGGTTCGAACGCAGCGTCGCCGAGCTTCGCGCGATGGGCGTTGGGGTCCTGTACGGCAAGGACGGCTTCATCCCCAACCAGCCAGGCCAAGGCAAACCCAAGGAGTACCCCTGGCACCTCCTCCTCGACGCAGCCGAACACGCCTCACCCCCGAGCTAACACCTGCTCCCCAAGTGCAGCAGGGGCAGCCCGCTCATCCACGGCAAGGAGCCACTCAATCTCTCGTCATGGGCCGTAACCCATGGGATGGCCCGACAACGGCCTCGCCCATACCGCCGCCTTCGTCAAGGAAAGGTCCACCCCCTCCTCTGACCACAAGCCACAGCCCGACTACTACCGGCCGCGGCGAGCAACACATCGGCCAGGCGCTCCGCAGCGTCCGGGCACCTGTGGGAAGGAGCTCACTCGGCCATGACTGCGTCGTTGAGGACCTGTCAGCAACGGCGCCGCCGCGCCCGCAGTGGCTCTGGGAATTCCTCGCCGGTGAGCGCAACCACGGCCCCAGCATCGACGCGGCGCCATGCGTTGTGAGACCTGACCTCCTTGCCGGCCGCAGGTGGCGAGCGGCGTGAACCCGCCTGGTTCTCTCGGCACGATCCGCTCCGCGATCATCCCGGCCGCTTGCTCTTGGCTGTTGTCCTGCGCACGCTGCAGGTGCTGTGGACACTGGCGGAGTGACAGATAACTCCATTTCTTTTGTAGCCAACCTCATCACCGTGTTCTTCGCCCTGGCGATCGGCACCCGTCTCGGCTACATCGTCGCAGCTCGCGGAACAGCGCACCACATCGATCTGATAGACCGGCACTTCGAGAACAGCCGTCGGCTCTTCGAACACCAACAAGATATTCAGCGGCAGACCGACGCGCACAGGAGGTCGCGTGAGGAGCTGAAAGACAGCTATGAAGCACTCGGTATCTGGCTTCACCGCCTGGGCCAGACCCTCGACGAGATTTACTTTGGGGCCGTGTCGGACAAGCAGCCGATGCGGGACAAAGCCGAAGCACTCATCAGCGTCCGACCCTGGGAAGTCGTCTCACCGCCAACCAGCACAGCCGCAGCCGCGTTCTACTGGAGTCCGGAGGTGCTGCGGAAGATTCGCGAGCTGCAGGGTCCTTACGCACAGTTCGTCGCACACATACGGCTGACCATGCTGCCGACCGAGTCCGACGACGCCCCGGCATCATCCCGGCCCGAACAGGGGTGCTGGCAGCAGTGGCAGGAACTGCAGTCCCTCATCGCGAGCATCAAGAGCCAGGCACGCGCGGACCTGATGCCCACCTCGCCGACTGTCAACGAACGCTGATGAACATCAGGGCGTACGAGCCCGCCTGCGCATCTTGGGAAGAATCCGCCTTCGCGCCTGTGACGTCGGCTCGTGCACGGCCTCCACATACAAAGGGGTCGCCACCACCAGCCGGTGAACCCACCGCGGACGATCAATGTCCATCAACACAATGGCATGCCCTCGCAGACGTCCCCGAGTAGACGGCGGGTGCTCTCGCTGAATCCAGCCGTGCACCCCGAACGCGGCGTCTTCGATGAGCACTTCGCTGCGGCGATGGGGCATCAGATCATTGAGGAACTCGGGAATCACGTTCAGTCCGCGGTCCTCACGACGCTCAACCTCGAGAATCAGATCGTGCAGCCACGTGGTATCCGAGCCCATCCGGCCTCGCCCGCACACCTGCGTACGCAGATGCTGCACCGAGCCGCACAACATGAGCCCCAGGTCGCGCGGCTGGCCAGCCGTCCCCGCAGGAACCTGCCCGACGAACAAAGCAACGTCCTCGGGCGGTGTGCCACTGTCTTCGTGAACGGCTACTTGAGCCATGTCCAGATCGAAACTGACCCACTGATTCACCTGCAAGTTTCGGGTCGTAAACGGCACCGGGCTGAACCGCCGCTCGATGCTGCTCCGGGCCTTCTCCACTAACGCGTGCCCGGCGATTGGCTCAGCCGCCTCATCCCAGCTCCGGCTTCCCGACACCTCGATCAACGGCGGAACCTTCAACGAGGCCTGCAGACCCTGCTGCACGGAGACAGGCCGGATACCAAGCCGCCCGTAGATTTTGCGCTCAGAGACATAGACCAAATCCACAGCAATCCCCCACTACCCGCCCTGACGACTCGGTGAAGCCCTCGGCTTCAGAGGTCGTTCTCACACAAGCAGGCTCGCATAAAGGATCTACACAAGGGTGACGAAGGAGGGAATCGGTAGGATGAACGCGCCCTGACGGTCTGTCGGACACGGACGCACCACCATGGTCGCCCGCCACCTCTGCTTCGTACCACGAGGTTTCCTTGGAATCGCTCTTCGACGTGGAGCTCACGCAGGATCAGCGCAGCCTCCTCGACGCGATCGCCCATATGTGGCTCGCCCGCGGCGAGTAGCCGCAATGGGACATCGTCCAGTACCAGTTCGACATGCGCGGCCAGGACGCCGACGCCATCTTCCACTCACTGCCGCGCATCGGCGTCCAGGCGCCGTATGCCGCTGGCTACGGCTTCACCGTCCCCATGCGCGCCCCCATCAACGGCACTGACCGGGTTCGGCTGACTCTGGCCTCCGCCCTCAAGCTCACTGAGGTGTGGATGACGGCGGGGCAGTCGTTCGTGAAGGTCCTCCGTCACATGATCGACCTCTACACCAGTCGGCCCATGCACTTCGAGGTGGTCCCCACCGTCAGGTTGCGCTCCGACGCGCTGGCAACTGCACTCCCCGAGCTCACGCCATGGTTCATCAAAGTGCTGCCCGAGATCCTCTTCGTGGAGACGCCAGATCCGCCCGATGGAGCGCGCCGGGTCCGTCCCTTCGACCATGCCAGTTCCACACCCGGGAGGGGCACCTTCGCGTGGGTCGTCAGCACCGCGAGGACGTCGACGGCGAAGCTGCTCGGGCTCGGCTCGTTCATCTCCAACGCCCCAAGGCGCGCCGACGTCCAGGCCCCGCCGCTGCAGCCGAGGAAGGACGCGCCGACAGAGGACGTCGCGGACTGCTGGCACAGGGGGGGGCAGCACCGTAGTCGTGTCACCGCTTCCCCACCAGTGCAACGATGCACAGTTGGGCGATCGAGCTGTGTTACGAAAGCGGCGAGTAGCACCGGCCGGCGATCTGACCTGCACGTTTCATGCCTGCCTGATCATGTGTAACATTGGTTGACGTCGGGCATTCTTGTGCCCTAGTCAAGCTTCGAGCCCGCCTACTGGCGGGCTTTTCGCTTTCCTCAACTCATCCGGGCTCCCAGCTTCACGCTGGGGGCCTTTCGTCATTTTCAGGGCCGGAGGCTCTCATCGTGTTCCCTACTCAGCTCCTCCATACCAGCACCCTGATCGTGCTGGCAGCCCTCGTGCCGGTCATCGCGGCTATTGTGGTCTTCGGTGTCATCGCAGTCATGGTCGTACGGCGCCTGAACGGGGCCGACTTGGTCTCGACCCTGGAAGTCACGGGCCGCACCCTGGTTGCACTGCTGCCGAGCCGCAAAGCCCAGGGGGTGTTGACCGGTGCTCCATCGGGTTCGGCCTCGGAAGGAGAACAGCGATGAGCCGGCCGTCGACCTTCCGTGATCCGACGTCGCGTCATGCGGACGAACGGTGGCTGGATCGGGCGCTGAACGAACTGCATCCGTGCGACAGGGAGATCTTGCTCGCCTACGTGGGCGGGGCCAGCCGTACTCAGCTGTCTCTGGCGATCACCGCGACGAGAGAAGTCGACCAGCGACTCGACATGGTGCTGGGCACCATTCTGCAGCAGCTGCGCACCTCATCTGCGGTAGAGGGCTTGCGTGAAGATTACGCAGCAGAGCACGGTCCACGGCATTCGCTCATGATGCGCGCAGCAATGGAGGCACAGGACCGCGTGCCTCGGTGCGCACACTGCCGCAAGCCGATGCTGGAGCCGACCGCGACAGGCCGACCTCGCCGCTACTGCGGCAACGCATGCAAGCAAGCGGCTTACCGGATCCGCAAAACCGCGCCCTCAGGATCTGCTCCCCCACCAGGGGAAAACCTGTTTCCTGTGCGTGATCTCTTCGCCGCTGCCTGGGCTCTGCCGAAGGTAGGCGACGTGCCGCTCGCGGATCCCGAACTGATGAGGGAGGCACGTCAACGATGGCGGGAGCGCCACCTCACCTTCAGGAGGTACGGCACAGCGGGGCTGGTGCGAGACCAAGATGCGGACCGCCGGGAAGGAGTGCAGGCGATGCGCCGAATGGCCTCCGGACGTAACCGCGTGGGTGGCGCGCCTCGCTACAGCAGCCAATTGCACGGCCAGCGCAGCCGACGTAGGCGTCGTACGACGGCAAGCAGGTGTTTCCCTCGCAGAGACGCCTCCAGCTCGCTGTCCTTCGGGAGCGCGGGAGATGTGATGATGCCGTGGCCCGTACGATGCCTGTCATGCATCACCTCTGTGATTGACCAGCGATCGTTCCGTGGCCCTCCGTAGGCCGCGGGACACAAACGACGTCATTCCGGTCGTTCGTCCCGGTCATCGTTCGGGACGTCACACTGCTGGAGTCACTGGTGCTCTTCGCTCGACGCCGCCCTCACGCAAGTCTCGTCGCGCTCCTGCGCGACAACGCCGACTTCCGACGCCTCTTCTGTGCTTCCGCTCTCAGCCTGACTGGTGGCTGGTTCACTTCGTCGCCCTCAGCAGCTTCGTCTACCGCCATAGGGACTGCTGCGTGATCAGGTGACAGCGGGATTTATGCAGCCAGGGCTGCGGGTGGGGTCATGATGGTCTCGTACTCGATGGGGGTCAAACGGGCCAGGCGTCTTTGGCGTCGACGGCGGTGGTAATTGCGCTCGATCCAGGTCACGATCGCGATCCGCAACTCCTGTCGAATGGACCAGACTTGGCGATCCAGGACGTTCTTCTGCAGCAGCGCGAAGAAGCTCTCCATCGCCGCGTTGTCGCCGGCTGCCCCGACCTTTCCCATCGAGCCGGCCATGCCGTGGTGGGTGAGAACGGCGACGAATTTCCGTGAACGGAACTGCGATCCACGATCCGAATGCACGATGCATCCGGCGACCTGGCCGCGGCGGGCGATGGCAGACTCCAGCGCGGTCACCGCGAGGCGGGACTTCATCCTTGCGTCGATGGAGTAGCCCACGATGCGGCCCGAGAACACGTCCTTGACCGCACAGAGATACAGCTTGCCCTCGCCGGTGGGGTGCTCGGTGATGTCGGTCAGCCACAGTCGGTTCGGCGCCTGGGCGGTGAAGTCGCGCTGCACCCGGTCGTTGTGAACCGGCGGCCCCGCCTTGGCGTTCTTGCCGCGGCCCTTGCGCTTGCCGAACACGCTCCACCAGCGGTTGTCCCGGCAGATCCGCCAGGCGGTCCGCTCAGCCATCGCCTCGCCTGCGGCGCGGGCCTCGTCGACGAGGAAGCGGTGGCCGAACTCCGGGTCGTCGCGGTGCGCGTTGAACAGGGCGTTGGCCCGGTAGGCCTCGGTCAGTTCGGTGTCGGTGACCGGGGACCTCAGCCACCGGTAGTAGGGCTGACGGGCCAGCCCGAGCACCCGGCACGTCACCGCCACCGGCACACGACGAGGGGCGACGGCGGCGGCCAGCTCGCGGACGAGCGGGTACATCATTTTGCCGGCAGATTCGCCTGCGACAGATACGCCGCGGCCCGGCGCAGTACCTCGTTCTCCTGCTCCAGCAGCCTGATCCGCTTGCGGGCCTCGGCCAGCTCAGCCAACTCACTCCTTGCGGAGCCAGGACCGGCGGCCGGGCCCGGCTCGCCGCGTTCCTCAGCCGCCGCGCGTCGGATCCACTTCGTCAATGAGGCCGGGTGGACGCCGAAATCAGCGGCGACTTGCTCCAGGGTGACGCCGGGCTCGCGGTTGCGCGCGACCCGCACGACGTCCTCGCGGAACTCCTTCGGATACGGCTTGGGCAT

Protein sequences of DBSCAN-SWA_1

>CP034463|39176:84251|57950_58358_+|AZP14748.1|DBSCAN-SWA
MARPDHEADHVNAPLIENARTRQRVMPYINQAHTALPGLAVVEIAAADDTTAFAIQELLAARCAPPGCLPGQWKHGDAVAVGRDTDSTGHRDRVAAHPRRGQVRYEIRRNPTHAAGSQLPCGFPGVDPVAATLTR
>CP034463|39176:84251|47923_49141_+|AZP14742.1|integrase|DBSCAN-SWA
MWLCGGLLHDSWQEFGMRAFPVVMPSGQRYWTVLDDHLEVVSLADQWLRHLRFGRDRAELTTKAYAGSVALYLRWSGSTGRAWAEAGRDLGLFMVWLKYTPAPRDGVVPVVRAGPGAVPVRGERRINRVLVAVRGLLSYAVSVSEAPRSVLGQIYELADSRDLPAEAQGEDGGLFYRLRPVHSLREPETTVDRAADAALVAMFVACRNARDRLIVLLVGRVGLRRGQVAGLRRSDVHLLPDSRALGCDYPGAHVHVRRRENVNGAWSKSRPAWVAPLDFLVVSAFDLYYDERHRLLGMGGSDFLLVNLFRAPLGEPMSPEAIGELLERLSGRAGLDRRVGAHMARRAFASNVTDAGGQPDEVQAVLGQKSLDSQAPYLFPDPKRVRAAIERVPSPRGMAGPEDSR
>CP034463|39176:84251|75113_75518_-|AZP23012.1|DBSCAN-SWA
MQEFLEQLEIREAAGRDLADRLRTQIAELTTQLAAAEKALERLRITRETILEIAPDLPGGLAPLPSAYRQILALFEDTADGLRPKDVCIALDTGTEPRHVEGVRAKLKRLVSRGILTEPEPGLFRLPQPTPSPD
>CP034463|39176:84251|65080_65776_-|AZP14755.1|DBSCAN-SWA
MDLVEGSLAAAAALFTGWAAYSAMDAAKTAKKAAESSDHNGQTANRTAELAAQTAESVAQIERDRWHRELTPRLRVRVDLSEPNHVLVLRFEGPGELGRLQVRLSIRDDRDHSDDPVLGADPEEQRAERAAVIWGPLRFRQGVDRADAGERTAGPFHLEAHDERKVTVQPSMRPRWYEGASGELRWEADYRYQRPLRLWADCEAEGHKPWRLPFEVSTTSGAWAVPYADTA
>CP034463|39176:84251|66989_67373_-|AZP14756.1|DBSCAN-SWA
MEDEDTVFDLIASLYAVVHEEVTGPCADILTVICHAWLQQSPVGFPLLEDVPASFSALRERAARLFANGVYERDEHGGYVAAHSHHAHGGPGPGPGHRHDHAPRSATVPPVFRGLAYQPAAEQATIW
>CP034463|39176:84251|53837_54920_+|AZP14744.1|DBSCAN-SWA
MASHPLGLFPAHDADRHGKGKQKMHGLALYITHVWEAAATTDTSLCRVHGMEVDTERIALEVAPALAAIRTLDRDVICLSQTAAEQTRYLDFQKDDPQGRAVRGLLILRNADTHVPATIEVPADRVVGGVGLGYRVMPRWLSFDDLPDAIRNNPKNNPGAVQAYKDAVGGQLVMDTLLDAFAFIDRCDPTLARRVRGTDDLEYFPLHDYTTHDYDRLHPDQPSRPQLDAEIRRLTQETPPYGTGREILHSFNRDGQEVYCGNTIRHDIRTAFVEPGMQVTRDIRAGFPYSVITSDGTQHDVTVDEEGHLTAAGSPLASVPLQTPRNHCRPEVCEGWWELTTSDAFLYRQQRHLHEAIRDL
>CP034463|39176:84251|52192_53473_-|AZP14743.1|DBSCAN-SWA
MDTNILRGFELQSPKAELLRAIKTADVGGVSVPWAALEELAGQRARTYHLAHEKAEAALRALAKSAPTGNSGVVAPLDHDRVLQYWRQRYLEIVDVIPTSANALEQATTREAAVLPPCKAVDIVNEEGKVIKTIKTGGRDTAIWLSAVEYATEHPQETVYFVSENIKDFGRGETYKYPMDRDVEKLGDRFVHLLKLEDILPQFSEEIDVPESDLDSALRGQGNLETIAFETRFGAPLRPSRHQTGWRRFRSTQLEEPTGAELPEGIAEVWLGNPNVSFASVRDAKAYRIGDHVWCTAWVTWLLSGHALLNRTLDIAEVGCAWETRVLVSLTDSTSKLDILRSSTPRAATAQEADNLPEVDPLILPDYIAELDDRIRRNRMSRNMRHYLGQASTAEEALDMMLGFARPSPLPLPTAEVEVWVEPDED
>CP034463|39176:84251|71087_71288_+|AZP14757.1|DBSCAN-SWA
MKHTLPAFLLLALAVAVLFSVVAAAIAFALARWEGAAVPSALSRCGIAFAASLTLCLAIFSALDRT
>CP034463|39176:84251|56154_56559_-|AZP23010.1|DBSCAN-SWA
MQEFLEQLEIREAAGRDLADRLRTQIAELTTQLAAAEKALERLRITRETILEIAPDLPGGLAPLPSAYRQILALFEDTADGLRPKDVCIALDTGTEPRHVEGVRAKLKRLVSRGILTEPEPGLFRLPQPTPSPD
>CP034463|39176:84251|40238_42272_+|AZP14738.1|DBSCAN-SWA
MAGLGGRRWRRRWQMFGALGALAVVASVAYAMRQLLHGGLEPGDTAGLLGLPLGVIGLVVSVVALRNPVEGNDAERSRGWAATLAKQVEDGESGVWRQLLGDDTRRINLAYDLQPAVSRPAVALAAGRLTADGANSATVPDIVSYYRATQPLRLVITGAAGAGKTVLALELLLALLDGRAEDDPVPVRIPLSRWDTERQLLPDLLRQRLVEAYDWPTDLAAGLVRQHLVLPVLDGLDEMDPLVDGSPDPAAPRATAVVRALNAYQQGRDAGPLILTCRTRHYDALATHAEVLDAARITIAPVDATDARTYLTDRALTTDRWQPLLDHLAAHPSGLLATVLSTPWRLCLTATVYHRDGDPGELRTLLDASTLDDHLLARYIPAATRIAPNPHGYAPKDVHRWLHHLTTHLDPTGALPATAPTSVEATDLLLHELWPLAGRTRVRTTDAVLTTLAVLPSAWTAPLKPTGLAALITALAVMSGALAITTGQPTSTANPLRTRQGRREFAFWLAGGLVLGLAIGLAIWLAIGLAAGPTVGLAAGFATALTVGLTREPGTNLGARAVIRSDAMAGLMFGLTFGLAVGLAGGLEIGLAAGLAAGLAMGLAAGLSAGLAGGARASRRYAVFLLCSRRRLPFRLGLFLDWAVTAGLMRYSGPAYQYRHRELQHWLRQHPQPADLP
>CP034463|39176:84251|56575_57433_-|AZP14746.1|transposase|DBSCAN-SWA
MAERQPYPSDLSDEAWELIRPVITAWKGQHRSVSGHQGRYEMREIVNAILYQARVGCQWRYLPHDFPPYTAVYYYFGLWRDDGTDQTIHDLLRWQVRESKGRREDPSAVVMDSQTVHASVNAPKETTGLDPGKKSRGRKRGIATDVLGLLIAVIVVAASVHDNAVGITLLDKVAADNPGVVKSWVDAGFKNAVIEHGRSLGIDVEVVSRDPQAKGFAPSPKRWIVEQTFGTLMLHRRLARDYETLPASSASWIRWSMTDVMTHRLTATTTPTWRDRRRPASPGPA
>CP034463|39176:84251|57679_57886_+|AZP14747.1|DBSCAN-SWA
MRQIKKQHLKEPGLAMVEIAAADTATALAVQATLAGRWATSVTNPYREPGEPGVRLTCYLDIRQDNDT
>CP034463|39176:84251|77961_78510_+|AZP14762.1|DBSCAN-SWA
MTTTRVLYLFGSAAPPVFDVAQVIHNAHERGFDVCLGLTPTAARWLAPQLAELERLTGHPVRSEYKLPGEPDVWPTADVIAVAPATFNTINSWALGLTHDFVVGVAAEAIGKNIPTVTMPCVNAAYVQHHGFERSVAELRAMGVGVLYGKDGFIPNQPGQGKPKEYPWHLLLDAAEHASPPS
>CP034463|39176:84251|46131_47142_-|AZP14741.1|DBSCAN-SWA
MTTSAVTPDQVSTIMHVRCPDGLPEPAYRQLLELMAELSPIVQALPPSAAVVELKGALRYHGTDARRLGEILRIRSLSRLGVDVRVGIGPTITVAATASAQVPSPGGILAVAPGEADDWLGPLPVEALHGIGPRQAAVLRDYGIHCVGLLAAVPPATVHRLLGGRAGRIAADRARGIDPRPVVPRALPPAASVRCRFERHVLDGATVRAALLELVVRLGRQLRRRDQVARALTLTLTFAGNTRWEKTRRLVEPSAHDDDLRTLAYQLMDAAGLQRGRLTGLSLRGEDLIGADQAAEQISLDDAREARLVAETVVDRVRDKFGAGVIGPAAVFRRAS
>CP034463|39176:84251|75534_76392_-|AZP14760.1|transposase|DBSCAN-SWA
MAERQPYPSDLSDEAWELIRPVITAWKGQHRSVSGHQGRYEMREIVNAILYQARVGCQWRYLPHDFPPYTAVYYYFGLWRDDGTDQTIHDLLRWQVRESKGRREDPSAVVMDSQTVHASVNAPKETTGLDPGKKSRGRKRGIATDVLGLLIAVIVVAASVHDNAVGITLLDKVAADNPGVVKSWVDAGFKNAVIEHGRSLGIDVEVVSRDPQAKGFAPSPKRWIVEQTFGTLMLHRRLARDYETLPASSASWIRWSMTDVMTHRLTATTTPTWRDRRRPASPGPA
>CP034463|39176:84251|71858_73577_+|AZP14758.1|DBSCAN-SWA
MEPYVKLAFTMRDTPGAYAVLLGAGASIAAGMPSAWDVQEDLIARLAATEGSTGIGDPHAWYQERFSHSATYDDLLAALTSTPFERQALLRSYFEPDEQEREDGLKQPTAAHREIARLVAAGHVRIVLTTNFDRLVETALREVNIEPVVVADAADAAGLAPLHTIRCLVVHVHGDYLTPTSMLNTPEELDRYAEDIDRLLDRVFTDYGLIISGWSSTWDPALRNAIARSTTRYFASYWTDPRPLSETAQKLLTHRAFTYVQADADTFFTRTADAADAVTDTKRRHPASIDIAVAAAKRALDGFSQGITLHDTLRREIDRIAALPLRTTGPWNVGNRAETDAEHGRRLNTLETEMELLLTLVAVTAYWGNNTTDRWWLRDIEQLGALHDPGGDLGLMKLVRAPATMMIYAAGIAALANERWDTLAHVLTEPRVEQRINGKTYAAAALLSPWETLNVNGSSKRVHDQLRPVFTQHLALSETAYGEAWERFEYLRVLVEDDADLAFSLPHISPTGYLGTFDPAPAAWLKKQIDQYGDNIPVLREGLLDGSRQRLDQAVTRVEKSFNYMAQQMRYA
>CP034463|39176:84251|60402_61374_-|AZP14751.1|DBSCAN-SWA
MPRTIWSGAISFGLVTVPVHVQSATEDHSIRFHQYHLEDMGRVRVKKVCELEDREVSQSEIGKGYEYAQDQEVVPITDEELRELPLPTAKAIEIEAFVPLDSIDPIRIAEGYYLAPDGQVAAKPYRLLVQALGRSSKVAVAKYAWSGRERLGLLRVRDDVIVLHAMRWPDEVRSPAELLPPPTEVSDDEIEGALALMESMSRDDLEGPEFADAYTDAMAKIIEAKREEKPLPEAPESGKPGKVLDLMAALTESVQKAKASRGEAGDADVHDLTQAKKTTRKKTAAKKTAATKSTAKKTAAKTAKKTTARKTAKKSAGRKPRSA
>CP034463|39176:84251|51644_52157_+|AZP23009.1|DBSCAN-SWA
MQDGRHAGTERRRQRVQDAIAAAVRDGTALTASAIAHAARVDRTFLYRHRDLLDNLHTASSRSTSPSPGSAPTVTTASLQADLANANARATRLAARVRHLEEHLSRQLGERAWHESGLSAPADIAELHAAVTHLEQRTVELSRDLEERQAELEAARAANRELTRALNQRG
>CP034463|39176:84251|39176_40124_+|AZP14737.1|transposase|DBSCAN-SWA
MSKTTPLDREAKRRLAVIRHVEEVTGNVAMSCRYFGISRQAYYIWYRRYQAEGIEGLRTRSKAPKHSPNATHVEVVGKIIYLRQNYHFGPEKIAMYLKRYHDVTISKSGVWRILNRLDMGRLPASQRYKRHDRRWKRYEKKLPGHRVQIDVKFIEPLASMPQGRRGGRNKYFQFTAIDDCTRLRVLRIYPTLNQATAIQFLDYVIQRLPFQVEVIQTDNGAEFQSAFHWHVLDKGIAHTYIKPRTPRLNGKVERSHRIDAEEFYRLLEGVIIDDAEVFNDKLREWEDYYNYHRPHGGLGGQTPYERLKQKTTTQA
>CP034463|39176:84251|50454_51636_+|AZP23008.1|DBSCAN-SWA
MPDEPEDTEAGRDLPDEVLRELCAHLDELEAQSSTEVRVATELLIDTGRRPDEINTLPFNCLEQDPDGSDVLVYDNHKAYRLGRRLPIGAETAAVIRRQQQRVRERFPTTAPARLRLLPRPKSNPEGTKPLVDVSGHHRAWVKSLPDILVPVVAADADTRVTRLVPFDKKRIFPYAYRHCYAQRHADAGVPVDVLKELMDHRLVSTTMGYYRVGDERRREAVDRVTALQFDRHGDRVWRTAKSLLDSEHVRRAIGEVAVPYGVCREPTNVAAGGHACPLRFRCLGCEHFSTDVSYLPDLQAHLADLLRSRERLMSAFEADDWARTQAMPSEEEIRRIRRLIERVQTDLDDLTPEDRAQIEQAVTVVRRSRTVMLGMPRVRQPLPDVRPARTPT
>CP034463|39176:84251|64285_64642_+|AZP14754.1|DBSCAN-SWA
MELSATGEPAVVQEDTHVHVGLDLRPGSLTLIRDGEDFEPYRAVVQFVGVHDNPWAAQEVKFSATGPDGKNVGLTVDLLNDSWDGPRDDVPEAIWKVVALAATSAGDIGITYTAPGPT
>CP034463|39176:84251|43730_44726_+|AZP14739.1|DBSCAN-SWA
MPASSPGWSLPEPMRAVPVTDPALPAGWAAQLKWDGYRALVGRWADGRVAVRSRNGGDLTASFPEIEEAVRLLPDDTAVDGELVVWEGGRLAFERLQQRMHRRGAAATRAAGELPAHLVAFDLLRLNGQGLTGWPFSDRYAALQELFLKHHLAAPWSLCATTTDPVQAAAWLADYPAVGIEGLVFRPLASRYVPGGRGWTKYKMRHTTEAVVGAVTGSLTAPTTALLGRYDDAGRLRYAGRTTTLSTTARQTLAGQLRTGGADYPWTGRTFSAGWSSREHLSVRLVVPEAVAEVAVDVARDSPGRWRHPVRFTRIRADMTLGDVPLFGAAP
>CP034463|39176:84251|81645_81894_+|AZP14766.1|DBSCAN-SWA
MFPTQLLHTSTLIVLAALVPVIAAIVVFGVIAVMVVRRLNGADLVSTLEVTGRTLVALLPSRKAQGVLTGAPSGSASEGEQR
>CP034463|39176:84251|55346_56033_-|AZP14745.1|DBSCAN-SWA
MVAASAADADSWVASRVDDGDELRKELAPLVEELQKHDVVGNSLQAVRKWVAEQMLSLGSAAVLHTTWPWWVGAAGAGMTALLTVTAEAGQATGSIFIPLVLGVLGMGGGVAVLALRGTAHAASRGGQQMSKVTDYLFHRAGSIGAEPERLFEEQVRPALAALFEKHGRADAALAGPAPVVPRLRNMAETSLVLAIGLLVVSAIVFAVGFGDAWHKNTCVPSAVQYCP
>CP034463|39176:84251|58855_59296_+|AZP14750.1|DBSCAN-SWA
MERTASLTYLLRSLDHETAVLLLAYALYGANRADLARGLGGINEWLAHFKSQTALFQARLPRNHSSARELWYTDDGNSLVIDEELRALIREWKIEERFAPHCRQCRVVFERPKSARRPREYCSNACRQKAYRARRKAARSGDGDRG
>CP034463|39176:84251|83052_84251_-|AZP14767.1|transposase|DBSCAN-SWA
MPKPYPKEFREDVVRVARNREPGVTLEQVAADFGVHPASLTKWIRRAAAEERGEPGPAAGPGSARSELAELAEARKRIRLLEQENEVLRRAAAYLSQANLPKMMYPLVRELAAAVAPRRVPVAVTCRVLGLARQPYYRWLRSPVTDTELTEAYRANALFNAHRDDPEFGHRFLVDEARAAGEAMAERTAWRICRDNRWWSVFGKRKGRGKNAKAGPPVHNDRVQRDFTAQAPNRLWLTDITEHPTGEGKLYLCAVKDVFSGRIVGYSIDARMKSRLAVTALESAIARRGQVAGCIVHSDRGSQFRSRKFVAVLTHHGMAGSMGKVGAAGDNAAMESFFALLQKNVLDRQVWSIRQELRIAIVTWIERNYHRRRRQRRLARLTPIEYETIMTPPAALAA
>CP034463|39176:84251|76680_77871_-|AZP14761.1|DBSCAN-SWA
MPTPDENHTGARIREQRRLARLTQRQFAARLPYSYSYLTQVECGARPATADFVAACAKTLNIDVTVLTGQPYVTQLQRDRLAELVRPIREALDLYDLGPNPDVTARPAGQLVAGADQLCAQVRAAHLRTAARALPGIIAELTHTAWSTPSTALWQALASCYRTAHDISVKLGYYDLSAVALDRMDWAAQRASDPCLAAVRQYMRALVYFREGEYRIGQRLIASGQSVVGQDGTTREALAVTGQLHLGASVISARAEDAAAVQVHIGEARRIAGKLGDAGEIHWLSFGPTNVDLHEMSAAVEMHAYDDALTKAHKIGKKLPPQLATSRRAHFLIDQARTQMETGHADGALMSLLEARRVAPEQTRYHPAARETITGLVHLSRRTPDSLNHMAAWIGL
>CP034463|39176:84251|79661_80450_-|AZP14764.1|DBSCAN-SWA
MDLVYVSERKIYGRLGIRPVSVQQGLQASLKVPPLIEVSGSRSWDEAAEPIAGHALVEKARSSIERRFSPVPFTTRNLQVNQWVSFDLDMAQVAVHEDSGTPPEDVALFVGQVPAGTAGQPRDLGLMLCGSVQHLRTQVCGRGRMGSDTTWLHDLILEVERREDRGLNVIPEFLNDLMPHRRSEVLIEDAAFGVHGWIQREHPPSTRGRLRGHAIVLMDIDRPRWVHRLVVATPLYVEAVHEPTSQARRRILPKMRRRARTP
>CP034463|39176:84251|63880_64093_+|AZP14753.1|DBSCAN-SWA
MTLHERTPGETPPPSSAWLTRLTALTGLVSIIGIVVLSLTHNTEAAATVGAIGTAVTALGGVQIGVRNRQ
>CP034463|39176:84251|45405_46089_-|AZP14740.1|DBSCAN-SWA
MLLEPPGWPGRPEGLPHWPYVRAVDDALAARGIPPGSVHADCTTREYGGLTTYMWLTWDASRTRYRSSGIRLHWQERRGWFYALTCLNTREILLYAPLAPLRTVVPDPEHVTDVAEQLVRFRQIPDMEYRTEWERGEELRAAARDFRRAVLGLPPLAHPETPTGPGGRPDAEQEQGMRLTIDTLTDTYEQALAAVQAIYGHNEDAPHRRSPTDLGQALRPTMEEHER
>CP034463|39176:84251|74224_75042_-|AZP14759.1|transposase|DBSCAN-SWA
MGRGTWSWIVPDGLWEIAKPLIPPSRVRPQGGGTQDTPDETLFAAIIYVLVSGCAWRQLPPCFGISKSTAHRRFLIWSRAGVWGRLHEAVLHRLDDAGLIDVTRVVLDTAHVRAKKGGEHTGPSPVDRGKPGSKMHVLSDANGLPLLVGISVGNTHDSEGLKPMIEGHQTRHDPCNGRYFKPQRLHADKAYDRADLRRWLRWKRIGVRIARKGIESSERLGRRRWVIERTMSWLSGYRRLSPRYERNPRNYLAFLGLAAAICCYKRLVRLTT
>CP034463|39176:84251|80776_81502_+|AZP14765.1|DBSCAN-SWA
MRGQDADAIFHSLPRIGVQAPYAAGYGFTVPMRAPINGTDRVRLTLASALKLTEVWMTAGQSFVKVLRHMIDLYTSRPMHFEVVPTVRLRSDALATALPELTPWFIKVLPEILFVETPDPPDGARRVRPFDHASSTPGRGTFAWVVSTARTSTAKLLGLGSFISNAPRRADVQAPPLQPRKDAPTEDVADCWHRGGQHRSRVTASPPVQRCTVGRSSCVTKAASSTGRRSDLHVSCLPDHV
>CP034463|39176:84251|79025_79655_+|AZP14763.1|DBSCAN-SWA
MTDNSISFVANLITVFFALAIGTRLGYIVAARGTAHHIDLIDRHFENSRRLFEHQQDIQRQTDAHRRSREELKDSYEALGIWLHRLGQTLDEIYFGAVSDKQPMRDKAEALISVRPWEVVSPPTSTAAAAFYWSPEVLRKIRELQGPYAQFVAHIRLTMLPTESDDAPASSRPEQGCWQQWQELQSLIASIKSQARADLMPTSPTVNER
>CP034463|39176:84251|58517_58817_+|AZP14749.1|DBSCAN-SWA
MPIWLAVLAALLLVALLGMVVCMAWLIARRTPSADLPQVLLGLSHVISALCGLLPWGKPSAPLALQTPPVVEQEPAAVPTVVVVRSETALRSARSGHEG
>CP034463|39176:84251|61501_62512_-|AZP14752.1|DBSCAN-SWA
MQLPYVYRVTKYDPADRDEHGHYTGSEDTVSDHGEVEASYLQAVAAFAGDSGVDHLAVREPQVPSLAHFGVEPPVDGFGLDGLFPGGLTGFHDGAEVPLDIGLQLVRAMLREYGAWCRLEAEGAFAVHVGWDQYLYISSSRPCEEALAHTRELGLFPERLDASPYAFEAEEEEQVIQRPGDDDFWADLYWAVVTGQAGILEETYLEGASRWHHLTSDTIDPVRAGLAPRARLAVWPPLSTNIDAVLRALPADGLVEGVWQDDDGNIRSAIAEEDEFPELAARISRAHAAAFLSVYAGESVPLCTAVMPDNDGVLRARWRTEPTPGDRDWALRQPPG
>CP034463|39176:84251|67814_69728_-|AZP23011.1|DBSCAN-SWA
MVYLRDPLPVDDEEHAGPLVLRLQQVQPLHAGGGAAQCEVRPDSALFEVLNGALPVTTDSPVGDTALLELLGEGHKAPGGGHTVLVPLHGRRRIIGTAVLLRHPTEQPFQDADLSVAAEFATGSALAIDKIHSLRAAVQGLHLAHNLADTLKVVAHGVVAGLGYELASVNLVRPDGDLVVASFAGNPAAEAQITGRVGSRDSWERRLSMGENWGDLVFIPHTEGWVLDDDDVPQWYTDGPVPRFEDEWHPSDRLFAPMYTRSAPGAAHRELLGVISVDQPLTRRRPRPDERRDLEEYAFQAAIAISNARLRSNMQRALVRLEREQQALRASEESFRQAFEYGPNGMAIAEMDGGRHGSILRTNDALCRMLGRPASAMRRYSFSDFVHPEDMAILLRTSAEGGRAELRLGRRDGTYLWVSLRNSVVADAADGPRFLLIHVEEIEDRKRRELRLAHRASHDSLTGLPNSAELHARIDARLCAYRGHGSDTAAERVDDPHLRHADQAASPHIHVLAPVGDDNTHGLAVVFLALRDFKAINTRFGHDAGDRVLVEVARRLSKAVRDGDTVARYGGDEFVVLADGFGPADAHSAAVWMQSQIHLPIPLGNQTVQMRAGVGIAWAQCGTAPSDILRAARGFAS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
32731:32747	attL	NA	NA	NA	NA
AZP14737.1|39176_40124_+|transposase	IS481 family transposase	NA	NA	NA	NA
AZP14738.1|40238_42272_+	NACHT domain-containing protein	NA	NA	NA	NA
AZP14739.1|43730_44726_+	ATP-dependent DNA ligase	NA	NA	NA	NA
AZP14740.1|45405_46089_-	hypothetical protein	NA	NA	NA	NA
AZP14741.1|46131_47142_-	hypothetical protein	NA	NA	NA	NA
AZP14742.1|47923_49141_+|integrase	site-specific integrase	NA	NA	NA	NA
AZP23008.1|50454_51636_+	hypothetical protein	NA	NA	NA	NA
AZP23009.1|51644_52157_+	hypothetical protein	NA	NA	NA	NA
AZP14743.1|52192_53473_-	hypothetical protein	NA	NA	NA	NA
AZP14744.1|53837_54920_+	hypothetical protein	NA	NA	NA	NA
AZP14745.1|55346_56033_-	hypothetical protein	NA	NA	NA	NA
AZP23010.1|56154_56559_-	hypothetical protein	NA	NA	NA	NA
AZP14746.1|56575_57433_-|transposase	IS5 family transposase	NA	NA	NA	NA
57172:57188	attR	NA	NA	NA	NA
AZP14747.1|57679_57886_+	hypothetical protein	NA	NA	NA	NA
AZP14748.1|57950_58358_+	hypothetical protein	NA	NA	NA	NA
AZP14749.1|58517_58817_+	hypothetical protein	NA	NA	NA	NA
AZP14750.1|58855_59296_+	hypothetical protein	NA	NA	NA	NA
AZP14751.1|60402_61374_-	Ku protein	A0A076YN45	Mycobacterium_phage	2.8e-37	36.2
AZP14752.1|61501_62512_-	RNA-binding protein	NA	NA	NA	NA
AZP14753.1|63880_64093_+	hypothetical protein	NA	NA	NA	NA
AZP14754.1|64285_64642_+	hypothetical protein	NA	NA	NA	NA
AZP14755.1|65080_65776_-	hypothetical protein	NA	NA	NA	NA
AZP14756.1|66989_67373_-	hypothetical protein	NA	NA	NA	NA
AZP23011.1|67814_69728_-	diguanylate cyclase	NA	NA	NA	NA
AZP14757.1|71087_71288_+	hypothetical protein	NA	NA	NA	NA
AZP14758.1|71858_73577_+	hypothetical protein	NA	NA	NA	NA
AZP14759.1|74224_75042_-|transposase	IS5 family transposase	NA	NA	NA	NA
AZP23012.1|75113_75518_-	hypothetical protein	NA	NA	NA	NA
AZP14760.1|75534_76392_-|transposase	IS5 family transposase	NA	NA	NA	NA
AZP14761.1|76680_77871_-	XRE family transcriptional regulator	NA	NA	NA	NA
AZP14762.1|77961_78510_+	flavoprotein	NA	NA	NA	NA
AZP14763.1|79025_79655_+	hypothetical protein	NA	NA	NA	NA
AZP14764.1|79661_80450_-	hypothetical protein	NA	NA	NA	NA
AZP14765.1|80776_81502_+	hypothetical protein	NA	NA	NA	NA
AZP14766.1|81645_81894_+	hypothetical protein	NA	NA	NA	NA
AZP14767.1|83052_84251_-|transposase	IS3 family transposase	U5P429	Shigella_phage	3.1e-30	33.1

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP034463|10251453:10310934|DBSCAN-SWA
TTCAGAATAAGGTTCTGAGTCGCCGCAAGCAGATGATGCTGCAGGCGAGTTGGAGCAGGCCGTGGTGGAGGTCTGCGCGTATCTCGTAGCGGATGCGCAGGCGCTTGAACTGGTGGAGCCATGCGAACGTCCGCTCGACCACCCAGCGGGTCTTGCCCAGGCCCGAGCCGTGGGCGACGCCGCGACGGGCGATGAGCGGCTTGATCCCACGCTTCCACAGCAGGCGGCGGTACTTGTCGAAGTCGTACCCTCGGTCGGCGAACAGCCTGCGTGGCCGTGTGCGCGGGCGTCCGGGCAGGCCCCGGATCGGTGGGACCGCGTCAAGAAGCGGCAGGAGCTGTGTGACGTCGTGGCGGTTGCCGCCGGTCAGCGTGACGGCGAGCGGGGTGCCGTGCCGGTCGACGATCAGGTGATGCTTACTGCCCGGCCGGCCCCGGTCGACCGGCGAAGGTCCGGTGTGAGCCCCCCTTTGAGCGCCCTGACGTGCGAGCCGTCGATCGCCGAGTCGTCCATCTCCAGGAGACCCACCGCTCGCAGCTCGGCGAGAAGGACCCCGTGCAAGCGAGGCCAGACGCCAGCCTCCGTCCAGTCCCGGAGCCGACGCCAAGCGGTCACCCCTGAACAGCCAACGACCTGGATGGGCACATCGCGCCAGGCCACTCCTTTGCGTAGCACGTAGACGATGCCGCCCAGTGCGACGCGGTCCGATACCGGCAGTCGGCCGGGGTGGCGATGGCGTCGGGCAGGCCGAGCTGGGAGAAGCGGAGCTATGCGCTCCCAGAGATCGTCGGGAACGAGGTCGGCAGGCACGCCGGAAAGTCTGCCCGACGCGTTGTCAGATAGTGGCCGAGATGTCGATGCGACAGGCGGTAGCAGCCGGTCGGGTTCAGCGCCAGCCACCGTGGCGAGGCTCCACGCGCTCGCCGAACGGTGGGTCGAACACCTGCCCGTCGTCGTCGGTCACGACGTAGTCCGGTTCGGTCTTCGAGGCGGCTGCGTGCAACCGGATGATGAGGTCAGCGACAGGCACGATACGCAGCGACAGGGCTGCCGCCACCTGGGTAACTTCCTTGTCGATATCCGGATTGTGCTTGTCACGGGACCGTTCAAGGTGTTGAGCGGAGGTCTGCATGACCTCCACATCGCCTCCGCCCGAGAATGTGAGGCAGTCCCGCCACTCCAGCCCGATGATGATCTCCAATGCGTCCGCCAGGTCATCGGCGAGCAGCCCGCCTTGCCCTTCGGAACTCGCGAACACTACCGGCCGGCGACCGTTCTGCTCGGCACACAGGAAGTACGCGCCACCAGCGGACTCCCCGGCGATCACCTCCAGCGGCGCACCTGAGGCAAGCCTCAAGCCATCGCCATTGTGCTTTCTGTGGATGTCGAAGCCGAACGATGACCGCAGCAGCAGATCGACCTCCGGGGCGGTCTGGATCAGGCCAAGCAGATGATCACTTGAGGTCATGGCACGGACAATAGCGAGTGCCGACGACGTGTCAGCGCCAAGGTGAACAGCGCGCCCATGTCCGGCGGTGGCGCGACCCCGGGGACGGCACACTCCAGGCCGCTCATGCACCCAAGCCATCACCAGTCATTCTGAAACCATCAGTAAGTGAGTGCCTGCGACGCTCGGCGTTCTCGGCCAAGGCGCAGGGCACGCAGGTCACGTACGCCCCGCTCTACCGGCTGTTCTTCACGTTCCTGTGGCAGCGCGGACTGGACTGGAACGAGGCGTCGGAGGACGACGTTGAGGACTGGGAGGACTGGCGCCGGCGCGGGGCGACGAACCCGGCGCCGGTCGACGGCGGCACCTGGGCGAAGGAGCAGGCCGCGCTGAAGCTGCTGTACGGCATCGCGGCCAAGCGTGGCCTCGTGCCGGCGAATCCGGTGACGTTGGCCTCGCCGACGGACGTGAAGACGTCGGACGTGAAGTGGCTGTCGCCTCGTGCCTTTCGACTGTGGCGCAACGTCGGGCTCGGCGGCATGCTGCCGAGCGGCCTGGAGGACGAGGCGTGGCGCGGCCGTTCGGCCGGCCGGGACATGGCCTACGCCGACCTGATGTACTCCAGCGGCCTGCGGCGCCGCGAGGGAGGCACCCTGCTGCTCTGCGAACTCCCGGCGCTCGGGCGGCGAAACTACTACGCGGGCAGGGTGGGCCAAGGTGTGGCCAAGCGGGCCGGCTACACCTTCTACGTCGGCCATCCGGCGCTCCAGCGCGTCGAGGGCTACCGGATGAGCACGCGCGCCCTGGCGGTGGCCCGCGCGCGACGGCACGGCGTCTACGACCGGCTGCCCGACCTGCGCATCATCCAGTCGGTCAGCCGGGCGGGCCGCGTGCGGTGGAGAAGCCGGGACGGTCGTGCGGGGGAGAGCGCGCTCGGGAGGCTGACGGCGGCCGAGCGAATGCTGCTGTTCGTCGAGGGCGAGGACGGCCTGGAGCCGGCGATGCTGTGGCTGACCGAGAGCGGGCTGCCGCTGCGGTACACGAGCTGGACGAAGGTCTTCGAGCGGGCGAGCGACCGGTGCGCCGCCGCGGGGCTCGAGGTCTTCGCGACGCCGAAGATGCTGCGGCACTCCATGGCCCTGCGGACCCTGATCGCGCTGCACAACGCGCTGGACCGCCGGCTCGGGCTGACACCTGCCGAGCGCCTGCACTACGAGGAGGTGTACGGGCAGGTCTGGCTGATGGTCAAGGACATGCTCGGGCACCGCAGTGACCAGGTGACGCGGGACGTCTACCTGGAGCCGGTGCGCGGGCTGCAGCTGGAGTCGCTGCTCGGCGACGACCACAACCCGGTGAACGCAGAGAAGATCGCGGAGCTGGCGGCGCGCACGGGCCTGATCCTGGACGCGGCGTGAGCGGGCGCGGGCGCCGGGCGGCGCTGCCGCCGACGGACTACCGCAAGGCACCGGTGCTGGACGCGGACGGCCTGGTGATCCGCCCGGTCAGCGGCGCCGGGAAACCGCTGGGCGTGTGGGACTTCCGCGACAGCCCCGGCCCCGTCGACTTCCGGCGGGCGCTGGTGGCCGCCCTGGCCGCGCAGGGCCGGGGCTGGGGCAGCCAGGACACCTACCAGACGAACACCAGCACGCTGAAGCTGCTGTTCAAGCACGCGGCGGCGGCCGAACCGCCCGTCACCGCGACCGAGCACATCACGGTGGAGTGGTGGAAGCAGTGGAGCGGCGACATCCACGTCCGCCGGGTCCTGGCCGCGGTCGTCCGGCGGGCGCCCGGGGTGCCGGAGGCGACCCGCGTGTTCATGGAGACGCCGCGGCGCCGCCCGCCGGCCCGGCGCGGACGGCGCCGACACGCGAGCAACACGCTCGTCGACGTCGGCGAGGGCTCCAGCGGCCGCGCCCTGCGTCACGTGCTGGAGCTGACCGCACAGGCCCGCACCACCCTGGAAGCGCTGGGCCGGCCCGCGACGAAGCTGCTGGTCGGCCACCGCGGCCTGGGCGGAGCCGAGAATCTCCGCGACCACGAGGTCGGCAAGGCCCTGGAGGGCGCGATCCGGCTCTGGCAGCAGCAGGTTCGCGCAGGCGGCGTAGACCTGCCCGCCCGGGTACACGCCCAGGCGCTGCGCCACAGCGCGCAGGCGCACCACGGCCGGGCCCGCAACAACACCCAGGACACCCACGAGCGGGACTACCAGCTTCAGGACGAGGACGTCCGCGCCGCCTCGCGCGGCGCGGTGGAACTTGGGCTGGCCCAGGCTCTGGCCTCCGCCCGGCAGACGGTCGCCATGCGCCTGGTCGAGGAGGTCGACGCCGTCGGCGAGGTGAGCCCCGAGCCCGTGGCCCAGGAGGCCGGGATCGACGTGGAGGTGGCCCGCCGGATTGTGGCCGGTCGGCTGCGCACCCCGGTCGCCTCGTGCGCGGACTTCCTCAACTCCGACCACAGCACGGCCGGGATGCCGTGCGCGGTGTCGTTCCTGCTGTGCTTCTCCTGCCGCAACGCGGTGGCCACCGGCCGCGACCTGCCCCGCATCGCCTACCTGCACCAGGCGCTGGAGTCCCTGCGCTCGGCCGTGACACCGGCGGTGTGGGCCGCGGACTGGGCGACGCACCACGCGCGGATCGGCGACTTCCTGACCACCTACACCACCACCGACGCGCGGCCCCAGCTGTTCGCCGCGGTCGCCGACAGCGAGCGGGAGCTGATCCACGCGATGCTGGAGAGGAGGCTGGACCCGTGAACGCGTCCTCGCCCCTGCCCGCCGGCCCGGAGGTCGTCGACCCAGCCCCGGACGCATTCGTCCTGCCGTTCAACCGGCTGCGGCCCGGCTTCGACCCCGGGCAGCTGCCGCGCTTTCGCGATCTGGCCTGGCGCCTGGCGTTGATCAGCCCCAGGGAGTCGAACCGCTCGCTGGTCATCGACTGGAGCCGCTGCCCCGCCGGGCTGCGGCCCGGCATCATGCGCGCGGCGTTCGCCGAGCTGAATATCCCGACCCCGGCGGTGCTGCTCCAGCAGCGCGCCTCGCGCTCCACCACCCAACCGGGCACCCTGCGCCACAACTTTCAGATCTGGATCCGTTTCGCCACCTGGCTCGGCGGCCGCGGCATCACCGAGCTCTCCCGGGTCACCGCCGGCGACCTGGAGGCGTACGCCGAGCACCTGCGCCCGCTCGGCCGCCAGTGGCGCACCGACGCCAAGGCCCTGGGGGTGATCTCGCGGCTGTGGGCCTACGCCCCCTACCTGCCCGAGCACGACCGGCTGGTCATGCCTCCCTGGGAGGACCCGGCCGCAGTCATGTCCGACTTCCTCGGCGCCAACGACGACACCCCGGGCGGCGAGAACGCCGTCGCGATCGTGCACCCGGCCGTCATGGCCCCGCTGCTGGTGTGGGCGCTGCGCATGGTCCTGGATCTGTCCCCGGACATCCTGGCCGCCGCCCGCGAGCACCGCCGGCTGCTCGCCGCGATCCCCGACCGCGCCCCGCGCGGCGGCACCGAGACCGCGGTGGCCCACCTGCGCGGCCTGCTCGCGGCCGGGCAGCAGCTGCCCTCCAGCGGCGCGCCCGGCGCCACCGCCGTGCGCGCCCGCTTCGGCGGGCCGCTGCCGCCGATGGCCAACACCTTCCTGGCTGGCACCCTCGGCGTCACCACCTCCCAAGTCGCCCGCGCCCGCGGCCTCCTGACCGACGAGCTCACCCCGACCGACTTCGGCCCCGCCCCGCTCCTCGACGTTCCGCTCACCGCCCGGATCGGCGCCGCCCCGTGGCGAGCGGCGATCGGCTTCGACGACGTGGACGTGCTGATGCTGCACCTGTCCACTGCCGCCCTGATCTGCTGCGCCTACCTCTCCGGCATGCGGCCCGAGGAGGTCCTGGCCCTGCGCCGCGGCTGCTGCACCCGCGTGGAGCGCGACGACGGCACCGTACGGTTCGAGATCCGCGGCCGGCACTTCAAAGGGGTGCTGGACGAGGACGGCAACACGATCGGCGAAGGCGAAGTGCGAGCCGACCCGTGGATCGTGCTGGAGCCCGTCGCGCGCGCCATCGCCGTCGTCGAGGAACTCGAAGACGGCGAACAGCTCTTCACCCGCACCCTCTACCGGTACGCCAAGGGCACCTGCATGCCCCGCACCGGCCTGTCCCCCGACACCGCCGTGGAACGGATCCGCGCCTTCACCGCCTGGGCCAACCAGCTCGCCGCCGCCCACGATCGGCCCCACGAGCTGATCCCGCCCGACCCCGACGGCGCCGTCGCCCTGCGCCGCTTCCGCCGCACCATCGCCTGGTTCGTTTACCGCCAGCCCGGCGGCCGGATTGCGCTGGCGGTGCAGTACGGCCACGCGGCCACCGCCATGTCGGAGTCCTACGCCGGCCGCTCGAAGGCCGACATGCTCGAGGTCCTGGACCAGGAGAAGGGCCTGGCCCTGGCCGAGACCCTCACCGAGGCCGGCGAACGCCTCGCCGCCGGCGAGAAAGTCAGCGGCCCGGCCGCCGACCGCTACCGCGCCGCGGCCACCGAGTTCTCCGACCGCTACGCCGGGACCTACCTGGGACGACGCGAACTGCGCGCACTGGTCGCCAACCCCCGCCTCCAGGTCTATGAAGACCCGAAGGCGTTCCTGACCTGCAACCACGACGCATTCACCGCGCTGTGCAACCCCGACCGCGACCGGGCGCGCAACGGCGGCCGCAGCACCCCCGACCACTCCCGCTGCCACCCGGCGTGCGCGAACATCAGCCGCACCGACAGCCAGATCACTGCCCTGCGCACCGAGGTCGCCCGGATCGACGCGGACGCCGACGCCGGCCTCAACCCCTACCCCATCGCCGCCCGCGAACAACAACGCAAGGACCACCTCACCGCCATCATCAGCCGCCACGACGCCCAGCAGCCGGCTGACAGCGAACCCACGGAGCGACGATGAATGCCGCGGCCGCGCCCGGCCTGCACGACGGCGCGGCGCTGGCCCAGCTCGTCGGCGAGGCCTTCGCTCACGCCCAGGGCCACGCCGCCACCGAGGACGCCGCGGAGGTCCGGGCCATCACCGATGCCATGGTGCGCCTGCTGATCGGCGCCCCGCTGCACTCCGACGGCAAACTGACCATCGTCTCGCTGGCCGCCGAAGCCGGACTGCGCCGCAACAAGCTCACCCACAAACACACCGGGCTCAAGGACCTTTTCTACGCCCTGGTCAAGGCCCGAGCTCCCCTACCCGAAGGAGTGCCCGAGTCCCTGCGGGCCCGCGCGGCCAAGCAGCAGCAGGACCTGGCCCGAGTCCGCGCTGAACGCGACGATCTGCGTATCCAGGCCCAGCTGATGGCCCGCATCATCCAGGTACTGGAGATCGAGAACAGCAAGCTCAAAGAGACCAACACGGCCCTGCAGCGACAGGTGGCCGCCCATGCTTCGGTTCCCGACCTCACCCGACGACGCCGATGAAGGCCGCTGCGAGGCCCACCCAGACGTCCGCCGGGCGGCGAAACGCGGCATCATGGGCAAGCGCGGAGAGGCCGGTAGCGGCGTCTGGATGCCATACGGGCCGAGCCCGTTCGATGTCCGCTCGGGGGCTTCTCACTCGCAACAGGCGTTGTCGACCTGCATCCGCTACGGGTCCTGCGCAGTCGAAGGTGACCTACCGGCCCCTGTTCGTGCCGCGTCTTGGGATCGGTAGGGAGAACTGTCCTCACCTCGGCTGCTGGGGACGCGACAAACTGGGGCCTTCCCTCACTTAGTCGGATGTCGGCGGTGTCTTCGGTGCGCGGAGCAGGCACCCGATCGCGGCGGCGAGAACGATGATGCCGACGGCGATGAGTGAAGCGGACAAGCCGTCCATAAAGGCGGACTTGACGCCGTCTGCCAGGGCCGCGCCCCGGGCGCCGAGCTGATCGGCGACATGAAGGCCCGCAGCGGCGGAGTCCCGTGCGGCCTCGGAGGCTTCGGCGGGGAGCTGGTCGACAGAGTCGGGCAGGTTGGAGCGGTAGTGGCTGCCGTAGATCGAGCCCATGAGGGCGATGCCGACGGCCGAGCCGACCTCGCGTGTGGTGTCGTTCATCGCGGAGGCGACTCCCTGCTGGCCGCGGCCGAGTGAGCCGGTGATGGCAGAGGTGCCCACAGCTCCGGACAGGCCGATGCCGAAGCCCGCCAGGATGAGTCCGCCGAGGAAGGGCAGGTATCCGGAGCCGACGTCGAGCTGGGAGATGACGAACAGACCGGCGCTCAGCAGGAGCAGGCCGACGGTCATGGTGACCTTCATCCCGACCCGTCGCACCAGGTGAGGGGTGGCCTGGGAGGTGGGCAGGACGACGACGGCGACGGGAACGAGGGCGGCGGCGGCCTTGAGCGGGCTGTAGCCGAGGATGAGCTGCAGGTACTGCAGGCCGACGAAGAAGAACCCGAAGACGGCCATGAACTGCACAAGGACGGTGATCGCGCCGGCCCGGAAGCCGCGGATGCCGAAGAGAGCGGGATCGAGCAGTGGGTGTTCATGCCGCAGGCCGAGCCAGGCGTAAGCGGCGAAGGCCACCACCGTGACCACGAGGGCGGCGATCACGATGTGTTCCGTCCAGCCCTGCTCGTTGCCTTCGATGATGGCGAAAACGAGGGCGCCGATACCGACGGCCGTGGAGATGGCCCCGGACACGTCGGGCGGGGAGGGGTGCTCGTCTTTGGTGTTGGGCGACAAGAGGAGGGCGGTGACGGCGGCTACGAGGGCGACCGCGGCGCTGGTGATGAAGATCGACCGCCAGGAGAACCACTCCAGCAGGGCCCCTGCGGCGAGCATGCCGATGATGGCCCCGGCGGCGGCGAAGCCGGACCAGGTGGCCACGCCCTTGACGCGCTGCTCGGGCGGAAAGGCAGCGGTGATCGTGGACAGGGTTCCCGGCATGATCATCGCGGCTCCCAGCCCCATGACGACTCGCCAGACGATGAGCGTGGTGGTGGAGTCGGCGAAGGACGCGGCCAGGGAGGCGGCGCCGAAGACGATGGTGCCCGCGATGAGGACGTCGCGGCGGCCGATTCGGTCGCCGATGGCGCCGAGGGGCAGGACGAGAGCGGCCAGGGCGACGGTGTAGCCGTCGGCGATCCAGGTCAGTGCGCCGTTGGTCGCCGACAGGTCGATGGCGAGGTCCGGCAGTGCGAGGTTGAGAGCGGAGACGGAGGCGACCACGAGGACCAGGGACAGGCACATGGCGAAGAGCACGCCGTTGTGGCCGGCCCGGCCGGTCGCGACGGCGTCCTGCCGGTCTTCGGTCTGATCGTCGGACTTGCGGTGGGGGCTGGTGGACATGAGGAACCTGTCTCAGTCGGTGCTGGGCTGCAGGAGCTTGAAGACCAGGCGCGCGGCGGTGCGCTGCGCAGCCTGGCGCAGGCGCACGGGGGCCGGTAGGGCTGGGGGCGGCGTCGGGGAAGTGGCGGCCAGACGGGGAAAGAGTGCTTCGGCGTTGGTGCGGTTGACGGCCTTGAGCGTGTCCGGGGCGACGTTGTCGTCGAGACCGTTCGCGAAGTACTGCCCGGCGGGAGTGGGGGCAAAGGGCCAGTCGCTGCCGAAGAGAACGTGTCCAGGGCGGGCGAAGGCGAGCAGGGTGGGCAGGGCAGCGGGGCTGGAGGACAGGGCGGTGTCGAAGTAGAAGGAGCGGAAGTCGTCCAGTACGTCGAGTGGGCTGCGCGCGGTGTCGTTGGCGATGGTGAGGGCCATGCGGTGTGATGAGTAGGGAACGAAGCCGCCGGCGTGGCTGAGGATGAACCGGATGTCCGGGTAGCGGCGCGGGATGCCGTTGCGGACCAGGAGGTAGGCGGCGCGGGTGGTGTCCAGAAGGAAGTCGGCGGCGAAGGCGGGAATGCCGTCGACCGGGGGTACGGGCAGCTGCGCCGGGTGTACGAAGACCACGGCGCCACGGTCGTTCAGCGTCTGCCACAGCGCGTCCTGATCGTCCTCGCCGAGGTAGGTACCCCGGTTGTTGGCGAGCAGGGTGACGCCGTCAGCGCGCAGGTCATGCAGTGCACGCACGGCCTCGGCGGCGGAGGCATCGGCGTCGGGCATCGGCAGCGTGGCAAAGAAGCCGAAGCGGCCGGCATGGTCGGAGGCCAAGGCCGCGGAGTGGTCGTTGAGGCGTCGGGCCAGGTCGGCGGCCTTGGCGGGGTCGGTGAGGAAGCCGGTGCCGGGTGTGGACACGGAGACGATCGACGTGGTGATGCCCAGCAGGTCCATCAGTCGCAGGGCGGACTCGGGGCGCCAGTCGGGCAGAGCCCGGCCGCCGGCGTCGGCGATGCCGGCCGTGGCGAGCTCGTCGCGGTAAAAGGCGGGCACTACGTGCTGATGTACGTCGATGCGATGTGCCGAAGGGGACATGAAGCGGCCTTTCATGCGGTCTACGGGGTGCGGTGGGGGAGTCGCATCATCCCGGCCGTCGTCCGTGCACTGTCGGCCCACCCGACGAGGCTAGGAGTGCCGGTGCCTGGGGGTGCGAAGAAGTCCGGCGTGGCGGTGGGGGAGGGCCGTTGGGAGAGCGGCAGAGAAGGTCGGGGCGGGCCGGGTAGGTAACGGAGTCGCGAGTGTGGCTGAGTGATGTCATGTGCGGATGGAGGGCGGGCTGTCGTCAGATGAAAGACACCGACACTGAGCCGAGGGCCCCGAAACGCGCCTCCGCCTTCTGACCGGTGCCGATGAAGGGAGCGGTGGTCATGGCGCCGGGCAGGATGACGTGTCCGGCGTCCAGTTCCATGCCGAAATCGGCGAGGGCGTTGGCCAGCCAGGCGACTGCGGTGGCCGGGTGACCCAGGACCTCCTTGCCGCTGCCGAACGCCACCTGGCTTCCGTCGACGAGCAGATCCACGCTGACCGCCGCGAGGTCGGGTGTGTAGTCCATCGGGGTCCAGGAGCCGCACACCAGTCCCGCAGAGCTGGCGTTGTCCGCGACGGTGTCGACCAGTGTGATCCGCCAGTCGCGGATGCGGCTGTCGACGATCTCCAGCGCGGGCGCGATCGCCCCGGTGGCGGCCAGTACGTCAGCGGTGGTCACGCCGGGCCCGCGCAGTGGCCGGGCGAGGCGGAAGCAGATCTCGGGTTCGACGCGTGGGGCGCAGTACCGGGCGGCGCGTACCGTGCCGCCGTCGCGGTGGACCATGTCGTCCAGCAGATGTCCGAAGTCCGGCTCGTGCACGCCGAGGAGTTGCCGCACCGGGGCTGAGGTGAGACCGACCTTGTGGCCGATCACTGTGGCTTTGGCGGCCAGGCGGCGGGCGATGTTGTCCTGCTGGACGGCGTAGGCGTCGGCGAGATCGAGATCGGGCCACGTGGTAGAGAGCGGTTCGATCGGTGCCGTGCGGCGTTCGGCCTCGCGTAGCAGCTGGGCGGCTTCCACGCGGCGCCGGGCAGCTGCCGGCGTCATGCCTTGTTCCTCGCCGCCATGCGTGTCGCCGCCTCGTAGACCAGCTGGGCGTGCAATTCGAGCATCGCCACCAGGTCGACAGCGTCACCGTTGATCTCCCGCTGGACGAACAGCCCGTCGGCGCCCGCGACGGCGTAGGTCGTCAGGATCTGAACGGACTCCTCGTCGAGGCCCGGAACCAGCGCTTCGGCCATCTCGGCGATCTTCGCGCACGCGATGTCGCGGACTTGGAGGAACACCGTGCGGCCGCGCGGTTCGGCGGGGCGCCGCTCCAGCGCGAGCATCAGCCCCAGACGGAGGAAGTCGGGGGCGTCGATCAGTGACTTCGCCACGTTCCCCGCCATGGCGGTGACCCGCTCCAGTGGAGTGCCCGTCTCCTCGCCCGGGAGTTCGACCGCGGCCAGCCAGGTGTCGAAGCTGCGCTCGATGACAGCGGCGATCAGGTCGTCCTTGTCCTTGAAGTGCCAGTAGATCGAGCTGGCGGGCAGCCCGCACGCGGCGCTGACGGCGGCGATCGACGTGCCCTCGTATCCCCGCTCGCCGGCGATCTCCACGGCGGCGTCGAGGATGCGCTGTCGCGACTCCACTCCGTTCGCGCGCTTCTTGCGCGTCGTCTGCGGCTTCGTCATGGCAGGTGCTCCTCCTCTTGGTGCGCTTCGCGCCGGCCGCTTGACCGTCCCCGGCGACAAGCCTACCGTAGCACTCGTTCCAATTGGAGTGAACGCTACATCAACAGCCGTGCGGGCGAGATCGACAGTGAGGTGGCCTGATGAGTGAGACCGGGGCCGGAACAGAAACCGAGGACAGCGCCTATGACGTGGCGGTGATCGGTTACGGGCCCACGGGCGTGACCGCGGCGAACCTGCTGGGGGCAATGGGGCTGCGTGTTGTCGTCCTGGAGCGGGACGCCGAGATCTTCACCCGTGCCCGGGCCATCTCCACCGACGAGGAGGTCGTCCGCATCTGGCAGCGGATCGGCCTGGCCGAGCGGCTCAAGCAGGACATGCTGACCGAGCGGGAGGTGGACTTCGTTGACGCTAATGGCCGTACGTTTCTCAGCGCGCACCCCACCCCGCGCGGGCACGGTCACCCGCCGCAGATGTTCATCTACCAGCCCGCGCTGGAGCAGGTCCTGCGTGACGGAGTAGGCCGCTATCCGAACGTGAAGATCTTGTTGCGCCACGAGTGTCTGCGCCTGCGCCAGGACGCCGACGGCGTGGAGCTGACGGTCGTCGGCACGGCCGACGACTCCGTCCACCGGCTGCGCGCTTCCTACGTCATCGCGGCCGACGGCGGCTCCAGCCTCACCCGTGCCCAGCTGAACATCGGCTATGAGGGAAAGACGTACGAGGACCGCTGGGTGGTGATCGATACGAAGATGCTCAAGCCCTGGCCGGACCACGACAAGTTGCGCTTCCACTGCGACCCGGCCCGCCCGGCAGTGGACTGCCCGACCCCGCTCGGCCACCACCGGTGGGAGTTCCCCATCCTGCCCGGCGACGACGAGAAGCAGCTGACCACCGAGGAGGCCGTGTACCAGCTGGTGGCCCGGTACGGCATCTCCCGCGACAGCATCGAAGTCCTGCGCGCCACCGTCTACAGCCACCATGTGCGCTTCGCCACCCGCTTCCGCATGGGCCGGGTCTTCCTCGCTGGCGACGCCGCCCACGCCATGCCGCCGTGGATCGGCCAGGGCATGGCCGCCGGCGTGCGCGACGTGGCCAACCTCTGCTGGAAACTCGACGCCGTGCTGCGCGGCGAACTGCCCGAGACGGTCCTCGACAGCTACGAGGCCGAGCGCAAGCCGCACGTCAAGGAAGTCACGAAGCGGGCGGTGTTCGTCGGCGGGATCATCACTGAGCGCCGTCTGCCGGTCGCCCGCGTCCGCAACGGCGCCCTGCGCGCCCTGGACCGCATACCGGGTTTCGGCGATTGGATGCAGGACTCGAATTGGATCCCCGTCGCCCGCTACGAAGCTGGCCTGCAGGCCCGCCCTCGCACCAAGGCGACCGGCCACCAGATTCCCCAGCCCTGGGTCACGGGCCCCGACGGCACCCGTGTCCGACTCGACGACGCGCTCGGCGGCCGATGGATCCTTCTGCACGCGGGCACCGCCATCCCTCAGCCCGCCTGGAACCTCGTTGGCGTTCCTTCCCTGACCATCACACTTACCGGCTCCCGGCCGACCGAGGGCACCCTCGTCGATAACGACGGCGTCCTGCTGCCCTGGATGACCCGGCACGGCGCGGCCACGCTCGCCCTGCGTCCCGACGCCTATGTCTACGCGGCGACCCCCGGGGGCGCCCCGCTTCCGCCGCCGCCCCGCGGCTTCACTCCGTCCACGACTCCCCGCCCTACCGCGTCCACCGCCCAGTGAGGACACCGGCATCATGACGACGACACCGACCGGCCTGCCGACGATGCAGGAGACGACGTACGACATCGGCGGAAGGAAGATTTTTGCCGCGGAGACCGGAGACGGCCCGCCGGTCCTGCTGCTACACGGCGGAGGCCCCGGAGCCTCCGGCGTCTCCAACTACGCCCGCAACATCTCGGAGCTGGCCAAGGATTACCGGGTCATCGTGCCCGACCTGCCCGGCTACGGCCGCAGCACCAAGGGCGTCGACGGCAGCGACCCTTTCGGCTACCTGGCCGACGGCATTCGCCGCCTCCTCGACGAACTCGGCCTAAAAAAGGCGCATCTGGTCGGCAACTCTTACGGCGGCGCCTGCGCCCTGCGCCTGGCCCTGGACACCCCCGACCGGGTCGATCGCATGGTCCTGATGGGCCCCGGCGGCATCGGCACCACCCGCGCCCTTCCCACCCCAGGCCTCAACAGCCTGCTGAACTACTACACAGGCGACGGACCCTCGCGCTCGAAGCTGGAAAAGTTCATCCGCAACTACCTCGTCTTCAACGCCGCCGATGTCCCGGACGCCGCGATCGACGAGCGCTACCAAGCCAGCATCGATCCGGAAGTGATCGCCTCACCGCCGCTGCAACGGCCGTCCGGACCCAACGCCCTGCGGACCCTGTGGAAGATGGACTTCACCCGCGATGCACGCCTGTCCCGACTGCCCGTCCCCACACTGGTCCTGTGGGGAGCACAGGACAAGGTCAACAGGCCCTCCGGCGGCAGGATGCTCGCCGAGCGCATGCCCAACTGCGACCTGTACCTGGTTGCCAACACCGGGCACTGGGTCCAGTTCGAACGCGCGGAGCTCTTCAACCGGCTGTGCACCGACTTTCTGGCGGGCCGCCGATGAACACCGCAGCGACCAGCACCGCCTCCGTCTTCGGCGCCGTCCACCTCGGCTACATCATCATCGAGACCAATCGCTTCGCCGACTGGCGCCGCTTCGGCACCGACGCCATCGGCATGCACCACGACACCCTCTCCCGCGACCTGATGCGCTTCCGCCTCGACGACCAGGAATGCCGTTTCCTGCTCAGGCGCGGCCCAGCCGAGGACGTCGTCGCCACTGGCTGGCACATCGACGACCACGCCACCTTCGAACAGATCGAAGCCCGTATCCGCGCCTACGGCGTCCCGCTCGTCCAGGGCTCCGACGAGGAGGCCGCCCTGCGCGGCGTGGAACGCGTCCTGCGCTTCCCCGGCCCCAAGGGCATCACCCAGGAGATCTACACCACCCCGGTGAAGTCCGCCGAACCGCTGCGCATGCTCGCCTCCGGCTTCGTCACCGGCGACTCTGGCATGGGACACATCGCGCTGACTTCCACCAAGCCCACCCAGATCCGCGGCTACTTCAACACCGTCTTCGACGCCCGCCTGACCGACTACATCGACGAGACCATCAGCGGCGTCAAACTCAAGATCCGCTTCCTGCGCGTCAACGAACGCCACCACTCCATCGCGGTTGCCGCCACCCGCGGGCTGCCCATCGACCCGATCCGCACCCGCGTCCAGCACCTCAACATCCAGGCTGCCACCCTGGACGACGTCGCCCAGAGCTACCAGCGGGTGCACGAACTCGGCTTCGACATGGCCCTGTCGGTCGGCCAGCACACCAACGACAAGGAACTGTCGTACTACGCCCGCACACCCTCGGGCTTCGAGTGGGAAGTCGGCTGGAACCCGATCGTCATCGACGAGACGACCTGGGAACCCACCACCCACCAAGGCATCAGCATCTGGGGCCACCTCCCCGTCGGCCAGACCATCGTGGACAAGCTCGCCCAGTTCCGCGCGGGCGCCCGCTCCCTGACTTACCCCGAGAACACGGTGCCTGCCCTCAGTGGTGCAGGCATCGCCGACGACTGACCCGCGACGGTCACTCCGCCGCCCGGCGGAGTGACCGTACTCCCCCGATCTGCGGCAGCGCGGCGCAACACCGCCGCCAGCCCTCTCGGCCGGTCGCACACCCGTCGCACTGGGGCTTCACCAGGCACCTAGCCTCGCCGCCGATCACGGGCGAACTCTTGCGGTCCCGGCAATCCCGAACGCCTGCGGTTCGGAGCGCCGACCTGTCACCGTCCCACACTGCTCGGTCCGTCCGGCATACCGATCGCCGTGCTTCCCGTCATGGGATGCCAGGAACCGTGATGCCCGGGGCCCCATTGAGTGACCATCTACCTCGCGAGAGGACCCCAACTCATGTCCGTCCCGCCTCCCATGCCCGGCAGCGGGCCCCCGTCAGACGACCGGCCCCATGAGGCTGTCGCGGGCGCCCTGCAACAACTGCCTCGCACGCTTTCCGACGCGCGCCGGCGGTTCCTGGCGCTCAATGGCGCCGCCTTCCTGCTCACCGCGCTGCTCTCCGGCACAGTCGGCGAGCTGTCCGCCATCCGTCTGGCGAGCAGGATGCCACTGGGCGTCGTGCTCGCTGCTCTGCAGATGGCCGTTCTGCTGCTGACCTCATGGTGGTACGACCGCACGCTCCGCCGCCACGCCGATCCACTCGTCGACTCGATGCGACGTCATGCCGAACTCGTGCACCCATCGCTTCCTCAGCCGGGCTCGGCAGCAGCCATGTCCCGATGGCCGTACTCATCGCAGGGGAGACAGAGATGACCGAGCTGTCACTCGCCGTAGGGTTCACGTCGGTCTCGGGCGGTTCCGATGAACGGGCGATGGTGCTGACCGCCTTCATGGCATTCATCGTCCTGTCCCTCCTGCTGTGCATTCTGGCCGGTCCCGAGGGCGACACGACGGCCGACTTCTACACCGGCAACCGATCACTGACGCCGGTGCAGAACGCGCTGGCGCTCACCGGGGACTACATATCGGCCGCCACACTCCTGGGCGTATCCGGCCTGGTGGCCGTGGCCGGGTACGACGGCATCTCTCTGGCAGTCAGTAGCTGCCTGGCCGTCGGCGTGTTCCTGCTCCTCGCCGGTCCGCTGCGCAATGCCGGCCGCTACACCCTGGGCGACATCCTCGCGCTGCGTTCGCCGGGTTCGTCGTCCCGTATCGCTGCCGCCACGGCCACCTTGGCCGTCTGCGTGCCCTTCCTCGTCCTTCAACTGGCCGGAGCCGGCAGCGCCACAGCACTGCTGCTCGGACTGACCAGTCTGGGAGCCGAACAGGTGTGCACCGCCTTCGTCGGAGTGCTGATGATCGGCTACACCGTGCTCGGCGGCATGAGAGGGACGAGTCTCGTCCAGATCGTCAAGGTGGCCGTGGTGTTCACCACCATGGTGCTTCTCGCCCTTCTGGTCCTGCGGCACCACGACTTCGACCTGGGCGCCCTGCTGACCGCGGCCGAGCAAGGGAGTGGGCTTCACGGCCGATACTTCGAACCCGGCCAAGCGCTGAGTGACGGCGCCGCCGGGCGTCTCGACTTCCTGAGCCTGCAACTGTCCGTCGTCCTGGGCGGCGCGTGCATGCCGCACGTCCTGATGAGAATCAACTCGGCCACTGACAGCGCCACCGCCCGCCGAGCGACCCGCTACGCCATCGCCATCATGACCGCTTTCTTCCTCTGCGTCGTCATCGCAGGACTCGGTGCTGCCGGTGTCGTGGGAGGCCAGAAGATACGTGCCCTCGACAGCAGCGGCCAGATGGCCCTTCTCCTCCTGGCCGGGGAGCTGGAGGCCGGCACCTCAGGACTTGCGGGCAACGTGCTGTACACCGCTGTCGCGTGCTCCGTCTTCGTCACCGTACTGGCGGTAGTCGCCGGCATCGCACTGAGTGCCGCGGCCGCCCTGGCGCACGACCTGCACGCGCACGCGGCACGTAGGGGCCGTATGTCCGAGCGTCGGGAAGTCCGATCGGCCAGATGGGCCGTAGGAGCCGTGGGCGGGCTCTGCATCTTCGTGGCGGTAATGGCCCAGGGACGGAACTTTCAGTCCCTGACCCATCTGGCACTCACTCTCGCCGCCTCCACGGTCTTGCCGGCCTGTCTGTACGGACTGTTCTGGAGCAAGTACAACCGGACCGGGCTGCTGTGGACCGTATACGGCGGTGTCCTCTGCACCACCGCCCTGTACGTCTGCTCCCTCTCCTTCTCAGGCACGCCCACCTCACTCCTGCCGGGACAGGACTTCCACCTCGTCGGGCTGCAGTCGACCGCTGTAATGGCCATTCCCGCGGGATTCCTGCTCGGGTGGATGGGCAGCGCCGCCGGACAGCGTGCACAGCCCATGGAAGGAGCCGGGACGGACCTCCGATGGCGTGAGCGGGTTCTCGTCGGAGCACGGGAGGAATGACGTGCCGCGGCCCGGCCGATCGGCCGGGCCGCGGCACACGCTGCGGACTCACAGCAACAGAAGGGGCTCACCGTCGTTGAGCCCCGCTCAGGCCGGCCTGGCCCCGATCCTGGCGGCCAGCGCGGGGAATTGAGCCAGCGCGTTGGACCGCTCGACGGCCAGTCGCTCAGCAAACGAGAAGGTCCTGTCCAGCTGCGGTGCGGGGTCTCCGGCAGCGGGGAACAGGGCACTGGTGAACGGCCAGTCGGTGGCGAAGAGAATGTGCTCAGGTCCGGCCAGTTCGCGCACGGATTTCATCGCCTGAGGCGCCGGGGACAGAGCGGTGTCGTAGAAGAGCTTGCGGAAGTACGGGCTGCTGTCGTCCAGCCCGGCGGCCCCCACCTGCTGTGCGATCGCCGGGGTCAGGGTCAGCAGGCTGGTGCGGTAGGAGATGTACGGCAGAGTGCCGCCGGCGTGCGCGGCCAGCCACCGGATGCGTGGGTACCGCTGGTAGATGCCCTTGTAGAGCATGTTGACCAGTGCGCGGGTGGTGTCGAATGTGAACTCGTACAAGAACGGCGGCAGCCCCAGATCCGGGTAGCCCTGCGGGGTCACGGGGTGGATGAACACCATGGCACCCAGGTCGTCGAGCGCCTTCATCAGCGGTTCGAACACGGGATCGCCCAGGTACTTCCCGCCGTAGCTGCTGAAGATGCCCACGCCGTCCAGCTCCAGGTCCCGCACGGCCCGCCTGGCCTCGGTGACGGCGTGGGAGACGTCCTGCTCGTCGGCGGTGCCGCTCAGGGGCAGGACGGCGAATCCGCCGAAGCGTCCCTTCAGGCGTGCGGACGCCGTGTGGACCAGATCCCGGCTCGTGTAGGTGTTCAGACGCTGTGCCATCGCCACCCGTTCCTCCGAGGAGGACAGATAGGTGACGCCCGGCTCGGAGACAGAGACCACCTGGGTCTGGATGCCGTAGCGGTTCATGAAGTCGACCGCGAGGGTCGGGCTCCACGCGGGAATCGGCACGCCTCCAATGTTGGTGATGCCATGCGCCGCCAGGGACCGGCGGTAGAAGTCCGGGATTAGATGGCAATGCACGTCGATGCGGTCCCTGCCGCGGCGTGCCGGAGCGTCCGAAAAGGCGCTGCCGGTCGCGCTCGCCGACCCAGTGCCGAGGACTGTCGCGGTGGCTCCCAGCGGCAACGCCGCCTTGAGCAGTCCGCGCCGTCTCATGCCGCGTGAGTCGGCTCGTTCAGTAGCGCTCATAGAAACACCTCACCGAAGGAGTGAAAGGGGGGAAGGTGGCTCCGCTGGACGGTTCACGCGGACACCGGTGCAGCCACAAATGACCGGTGCAGCGATAACCGCACCGGCACCAACCTTCTTGTAGTGGTCACTACAATGGCTGGAATGATCGCTACGGTAAGAGGGGTGGGGGTGGGCGTCAAGGATCGCGGCAGTGGTGATTCATGAACGTGCGGGAGGCCTGCCGGGTTGCCCGCCGCCCTCGGCCGGTCGCTCGGTGCCGACTCAGGAAGAGGTGCCGCCCACCGTTCCGCTGCCCGAGCGCAGCACACGGGACAGGCCCAGAGCGGCTGTCCGCACAGCGGGCGCCAGCTGGGCGGGGTGAAACCGGCCGCGCGGCACGGCGACGGACAGGGCGGCCACCGCCGTCGGCCCGGCGAAGACGGGCGAGGCGATGCAGCTGACGCCGAGGGCGGCCTCCTGCTCCTCATACGCGAGACCGGAGACCCGGATCTGCTCCATGGCCGTACGCAGCCGCGCCGGGTCGGTGACCGAGTGCGGAGTGAGACGGGGCAGAGGCCCGGCCAGCACCTCATCCGCCAGCTCGGAGCCGGAGAACGCCAACAACGCCTTGCCGACGCCCGTGCAAGTCAGGGGGAGCCGCCCCCCGATGCGCGAGGGCAGCGCCAGGGCCTGGTGGCCGTGGATTCGCTCGACATAGACCACGTCGTGCCCCTCCCGAATGCCGAGGTGCACGGTCTCGCGCGTGGCCTCGAAGAGGTCCTGGAGGAACGGCAACGCCGCCTCCCGCAGGTCGAGCCGGCGCGGTACCAGCGAGCCCAGCTCGAAGAGCTTGCCCCCGAGCCGGTAGTTCTCGCCGTCGCGTTCGAGCAGACCGAGGCGCACCAGGTGTGCGCAGAGACGGAACGCGGTCGTCTTGGCCAGTCTCGTGCGGGCAGCGATTTCCGTGAGACGGAACATACCGCCGTCCGGGCGGAAGCAGTCGAGGACGGCAGCCGCCTTGTCGAGCATGTTCCCCTGCGCGCTGTTCCGTGTCATGGAACGTATTTTGCCGCTGCTCGAGGCGTACGCCTATACCTGTCATGGATCCACGGACGGCCACCGCCGCCTCTACGCCAACCCAGCCGCTCTCTCCCCGGAGGTAACCCGCATGTTCGCTCCGCACCACCGCTCCACTGCCTGCCGGGGGCGACCGTGAGCACTCACAAGCCGGCCGACGCCGTGACCCAGGCGGCGGCCGTCCTGGAGGAGGCCGCCCGCACCGGCGCCCCCTGCGCCCCGGTGCGCTCGCTCCTGCCCGAAGCGGACATCGACGCCGCGTACGCCGTGCAGCGCCTGCACGTGGAGCGCGGGGTCGCTGCCGGGCGGCGGCTGGTGGGCCGGAAGATCGGCCTGACGTCACCCGCCGTGCAGCGGCAGCTCGGCGTGGACCAGCCGGACTTCGGCGCGCTGTTCGCCGACATGGCGGTGTCCGAGGGACAACCGATCGCCCCCGGCCGACTCCTCCAGCCGAAGGTCGAAGCCGAGGTCGCCCTGGTGGTGGGCACGGACCTGCCGCATCGCGACCCGACCCTCGCCGACCTGTTGCGCGCCACGGCGTTCGCGCTGCCCGCGCTGGAGATCGTCGACAGCCGCATCGCCGACTGGGACATCACCATCGTCGACACCGTCGCGGACAACGCTTCCTGCGGCCTGTACGTCCTCGGCGGATCCCCCGTCCCCCTGGACCGCGTCGACCTCCGGGCCGTGACGATGACCCTCACCAAGAACGGCGAGACGGTCTCCAAGGGCACCGGCGCCGACTGCCTGGGCAGCCCTCTCACAGCCGCTCTCTGGCTCGCCTCCACCCTTGCCAGGCTCGGCGACCCGTTGCGGGCCGGCGACATCGTCTTGACCGGTGCCCTCGGCCCGATGGCCGTCGCCGCCCAGGGCGACGAGTTCACCGCGCACATCGAAGGGCTCGGCACGGTCACGGCCATGTTCGCGTCCGCCGCCACGGAAGGAGCCGCGGCATGAGCACGAAGGTCGCTGTCATCGGGTCGGGGAATATCGGTACCGACCTGATGATTAAAGTTCTGCGGCTCTCCGACTCCCTGGAGATCGCCGCCATGGCCGGGATCGATCCCAACTCCGACGGCCTGGCCCGCGCCCGCCGCCTGAAGGTCGCCACCACCCACGGGGGCGTCGACGGCCTAGTGGAACTGGACGAGTTCGCGGACGTCGAGATCGTCTTCGACGCCACCTCGGCCGGTGCGCACCGCCGCCACGACGAGGTGCTGCGCTCGCGGGGGCGCAGGGTCGTGGACCTGACGCCCGCCGCGCTCGGCCCGTATGTCGTCCCGCCGGTCAACGGCGACGACCACCTCGACGCACCGAACGTCAACATGGTTACCTGCGGAGGTCAGGCCACCATACCGATCGTGGCCGCCGTCGCAGCCGTGACACCCGTCCACTACGGCGAGATCGTCGCCTCGATCTCCTCCCGCTCGGCCGGTCCCGGCACCCGGGCCAACATCGACGAGTTCACCGAGACGACCTCGTCGGCCATCGAGAAGGTGGGCGGCGCTGCCCGGGGCAAGGCGATCATCGTCCTGAACCCGGCCGAACCCCCGCTGATCATGCGCGACACCGTGTACTGCATCATCGGCGAGTGCGACGACACCGCGGTGACCGCCTCGGTGCAGGACATGGTCGCCCGGGTCCAGGCGTACGTGCCCGGATACCGCCTCAAGCAGAAGGTCCAGTTCGAGCGCCTTGCCGACGACGATCCCCTGCGCTCGCTGCTGCCCGCTGGCACGCGGTCCGCCGACGCCGCGAAGGTCTCGGTCTTCCTGGAGGTCGAGGGCGCCGCCCACTACCTGCCCGCCTATGCCGGCAACCTCGACATCATGACCTCGGCCGCCCTGCGCACCGCCGAACGCATGGCGACTGCACAGCCCTTCACGGAGGTGGTCTGCCGATGACCGCGAACCAGCCCCCAGCCCTGTATGTGCAGGACGTGACCCTGCGGGACGGCATGCACGCCGTACGCCACCGCTACACCGTCGACCAGGCCCGCACCATCGCCGCCGCACTCGATGACGCCGGGGTCGCCGCGATCGAAATCGCCCACGGCGACGGCCTGTCCGGCTCCAGCGTCACCTACGGCGTGGGCGCACACACCGACTGGGAGTGGATTGAGGCCGTCTGCGATAGCGTCCACCATGCGGTGCCCACCACGCTGCTCCTGCCCGGCATCGGCACCCTGCACGACCTGCGGCAGGCCCACGCCCTCGGCATCCGCTCGGTCCGCGTCGCCACCCACTGCACCGAGGCCGACATCTCCGCCCAGCACATCGCCGCGGCCCGCGACCTGGGCATGGACGTGGCCGGGTTCCTGATGATGTCCCACATGGCCGACCCAGCTGAACTGGCCCGCCAGGCGAAGCTGATGGAGTCCTACGGAGCCGGGTGCGTCTACGTCACCGACTCCGGCGGCCGCCTGACCATGGACGGCGTCCGCGACCGCGTCCGCGCCTATCGCGATGTCCTCGAACCGGACACCGGCATCGGTATCCACGCCCACCACAACCTCGGCCTCGGTGTCGCCAACTCCGTCGTCGCGGTCGAGAGCGGCGTCACCCGCGTCGACGCCTCCCTCGCCGGCCAGGGCGCCGGAGCCGGAAACTGCCCGCTGGAGGCGTTTATCGCGGTCGCTGACCTGATGGGCTGGGAGCACGGCTGTGACCTGTTCCCCCTGATGGACGCCGCCGACGACATCGTACGCCCCCTGCAGGACCGCGAGGTCCGCGTCGACCGCGAGACCCTCACCCTCGGCTACGCGGGCGTGTACTCCAGCTTCCTGCGCCACGCCGAGGCAGCCGCTCGCCAGCACGGCCTCGACACCCGCGCGATCCTCGTCGAGGTCGGGCGACGCAAGATGGTCGGCGGTCAAGAAGACATGATCACCGACATTGCACTCGACCTCGCGAAGGCCGGCTCCGTCGGCTGACCGGGAATAGACGGCGCGAGAGACCTGGGGCCGTCCGGCGGAGACGGCGTCACCAACGCCAGGGGCCAGACAATGCGCCTGGCTTCTGCGCTACCTAGTCGCTAGCCCAGGTCCATCGATCAGTCACACGGACGCCGTGAAAACGGGCGTCGGGGAGGTGCAGACCCTCCCGACGGTGCCAGGCGAGCGCCCGGTCGGCCAGCTCAAGTCCACGACTCAGGCGGGGGCTTGAGCCGCTCCGAATGCCGCCGGTACGGCACGGCGAGTGCTCTGCGATCACTTCTGCGGCCGTCTCGCGGAGGCCCCCTGCCCACACCGCGCTGAGCCAGCGCCGTTCTCGCCAGCGCACGCGAGCCACGGCCTCCTGAATATTCGACCGCTCAACCAGCCCATGAGAAGGAGAATCATGAACCCGTATCACCATGACGGCAGCCTCGGACACTGGCCTGAGCCAGGTGATGACTTGGCGTCTGCCCACCCGCCGCGCCGGAGGATGCGTCGCAGGGCCGTCATAGCCGCCACTTTTCTGGTCACGGTGGGGGCGACGGCCATCATTGTCGACCGTGTCGCGGCGAGTCGCGCGGAGAGCCGTACAGCCGAAGCATTTCAACAGGGGATGGGCACTCCAGAGCGCCCCTCGGTCGATATACGCGGCTTTCCCGTCCTGCCGCAGCTGGCCTCCGGCACTCTGCGGCACGTGGACATCACCGCCCAGGACATACCCGCCCGCGGCACCAGCCGACCGCTGCCTGTGACCAGGCTCTCCGTCGGACTGGACGAGTTGCAGACCTCCGGCGAGGCCGATGAGGCCCACGCACAGACCGTGGACGCGACGGCGTTCCTGTCGTATGAGGACGTGTCGGACGCACTCGGTCTAGAGATAGCTGGAGACAGCGAGCCGAACAGGGTCAGGGCACAGCTCGTCCTGCCGTTCAGCGGCGAGGTGACCGTGAGCACGGCTATCGCAGCGGTCGGCGCCAACCGCATCGCCTTCACCGACGTAAGCGTCATTGACGGTCATCTGCCGGCTGCAGGACAGGCTCTGCTCGACAAAGTTCTCGCCGAACCCATTCAGATGCGCAACATTCCCGACGGCCTGCACCTGCGATCGGTCACCGCCACGCCGAGCGGTCTCAACACGCATCTCACCGGAGACCAAGTCACCTTTCGGCCTGGCACGTCTTCTGCGTGACCCCCGCTATCTAATCCCCTTGTGCCGTACCCGAACGGCTGTCCGTTCAGGGGACTTCAAGAGTGCTGTCTGCCTTGAACCACCGTTGAGGGTAGGGGGACCGTCACTCTGGTAGCTTCATCGAGTAGGCGGCAACACGTGTCGACCGTCCGCAGAAGCGGTGTGCGCCGCGGTGCCGTACGTTGCGGGCGCCGACCGCGACCAGGGCTTGCCGGAGCCAGACGGCCGGGTTGCACCCGGCCCGCGGAACCGGAGGCCCGAGGGCGATGAGCTGGGCTTCGGCGTACTGGTGGCCCTGCTCCTGGCGGCGGATCTTCTGCGCCGTGCGGTCGGAAGAACGCGGGTTCGCGGAATCTGGGGCGTGCGCACGCTTGAACCCGCGTGTCGGAGGTGCCTGGGGCGGGCTTTGCGGGCGGGTTCGCCGGGCTGATGGGTGGCACCGTGGACTCCGGGTGCTGATCGCACGCCATGAAGCGCTTGTGACCGCGCTACCATCGTGCAGCCCAGTCGTTGCTTATGGTGTGAACAATTCAACCCGGGTGTCCGTGGATGTCCTTCTGCGTCTCCATGACGTCCGTAAGGCTTATGGCCGGCGCCCGGTACTGCGCGGGGTAAGCCTGGACGTGCCGCGGGGCTGTCTGCTGGGCATCGTTGGCGCGAACGGTGCCGGCAAGAGCACACTGCTGCGCATTTTGGCGGGTCAGGCCGTGGGCGACAGTGGGACGGTCCAGTGCCGAGGGCGGATCGGGTATTGCCCGCAGAACACCGCGCTGCACCCGGCATTCACGGTCGCTGAGCATGTGCGGTCTTTCCAGGCCGCCTACCGGCTCGAAAGCTGTGCGCGCGCGTGGGAGCTGCTGGAGGAGCTGGGCTTCGACGAGAGCCCTCGCAGCCGCATGCACACGCTCAGCGGCGGGACGCGGCAGAAGCTGAACCTGGCCCTGGGTTTGATGCACGATCCTGAGGTGCTGCTCCTGGATGAGCGGTATCAGGGCTTCGACTGGGAGACCTACCTGCGGTTCTGGGACATCGCCCAGGGACTGCGGCAGCGGGGCCGCGCGGTCGTGGTCGTCTCCCACCTCGCCTACGACCGCGATCGCCTGGACGTGCTGTACCAACTCCAGGACGGCGTTCTCGCCGCCGAACACAGCAGCGCCGCGGGAAGCGTCGCATGAGCCGACGGCAGTCTCCGGTCACCGCAGTGCGTGACGACGCCCCCGGTTCAATGTCCGCGCTGCTGCGGCCTGCCCGCTGCGTGGGCTCCGGCGCAGGCCGACTGGACTTGGACCGGATCGTTCGCAGCATCGAGGAGGCGCTGACCGTGTTCGTGGCCGACAAGGTCAGCGGCAGCCGTGCCGAGGAGCCTGGTCTGGAAGCGCTGCTTGATGCGGTGGGTGACTTCATCTCCGCGCCGGGCAAGCGCATCCGGCCCTTGATGTGCGTGCTGGGCTGGTACGCGGCCGGAGGCACAAGCCCCGTACCCCCGGTCTCGGTCCTGCGGGTGGCTGCCTGCCTGGAGCTGTTCCACGCGTTCGCGCTCATGCACGACGACGTCATGGACGGCAGCGACCACCGTCGGGGCCGGCCGTCCCTGCACCGGACTCTGGCGGCGCACCACCCGGGCCGTCCCGGGGCTGACCGGCTGGGTGCGAACGCGGCCATCCTCGCCGGCGACCTGGTGCTGGTGTGGTCCGATGAACTCCTCACCAGCACGCCCATGACTCCCGAGCAGATCAAGGCCGTGCTACCGGCGGTCTACCGCATGCGCCGCGAAATCGTCACCGGCCAGTACCTGGACTTGGTGACCACAGGCCGCCCCACCGACTCCCTGAGTACCGCCTTGCGCATCGCCCGGTACAAGACCGCCCAGTACACCGTGGAAGGCCCGCTGCACATCGGCGCCGCGCTCGCCGGCGCGGATCAGGCGCTCCTGCACGTGCTCAGCACCATCGCCCTGCCGTTGGGTGAGGCGTTCCAGCTGCGCGATGACCTGCTGGGCACCTTCGGCGACCCCCGCCGTACGGGCAAGCCCACCCTGGACGACCTCCGCGAAGGCAAACACACCGCCCTGCTCGCCTGCGCTCTGCGCCGGGCGGACCGGGCCGGTCAGGAACTGCTTCTGCGCACGGTCGGCGCTGCGGATCTGGACGCCCATACGGCGGCCCGCATCCAGGGGCTGCTGGAGGAGTGCGGCGCCCGCCAGGCGGTGGAGGATCTCATCCAAGAGCGCCACCACCAGGCCCTGGAACGCCTGAACCACGCCCACCTGCCTCCCGCGGCGGCATTCGCGCTGCGCGACCTGATCCAGGCCGTGCACAACCGAACCGCATGACAGGCGCCGCTCTCGCAGTGACCCTGTCCTGTCACCCGTGCGCACCCATGCGGCCAGAGCCGGCCTCTCACCAAATTCGTGGAGTGAAAGTGTCAACGACCCAGCACAATCCTGGCCACCTGCACCGTTCACGCAACGGCGTCCCGACCGGCGACCGACGAGGTGTCACCGGGCGTGCCGCATGAGGTGGTGGGGGCGGTGTCTGGGGACAGCGGTGCGCCACGCTGCGCTGGAGCAGGCCCGCAAACGGCTCGCGCTGGTCCTGGTGCTCTTCTTCGTTCCGCTGTGGCTGACGCTCGCCTACCAGGTCCTGCCCAGCGACCCGGTCCGGTTCTTCCTGCGCGCGGCCGATCAGCGCGTGGCCCTGGGCGCCAACACGGTCAGCCAGTTGTCCGGTGGGCTGCACTCCCTTGCGCTGATCGTCGGGTTCATGATGTTCCTTGCTGCCAGCCGCTCCGCGGAGTTCGACCACCGCATGGTGCTCGCCGGCTACCCGCGCATCTGCCTGCTGCTGGCTCGCAGTACCGTACTGCTCCTCACCGCGGCACTGACCGCCTCGTATGCCACGGCATGGGTGTGCTTCTTCTATCGGCCTGAGCGCCTGGACGTCATGGCCGCGGCGTTCATGGTGGGAGCCCTGACGTACGGGGGCGTCGGGATCCTCCTGGCGGCGCTGCTACGCAGTGAGCTGGCGGGCATGTTTGCCGTCATCATGCTGAGCTTCATCGATCTGACACTGCAGAACCCCGTCGCCAACCCTTCTGCGGACAGTCCTCTGCTGAAGTGGCTGCCCGCCTACGGGGCGATGCAGTCTTCCGTGTCCGCGGTCGATCTCACCCACACCCCCTGGCGGCACCTGTTGCTCGGCCTGTGCTGGTCAGCAGGACTGACCGCCGCCGGCCTGGCTGCTTTCACCGCCCGCACCAGCCGGCGCACCATCACGCAGAGACTCCTGGGCGGGCGCGCCACCAGGCCCCGCGCCCGCCAGATCGCCCTGCGTCTACTGCACCCGGTCCGCACGTACGTCTACCGCCAAGCCGGTATCCACGACACCACGGTCATCACCGGCTACGAAATCTGCCGCCGCCTGATGCACCGGTCGGGTCCGGTGGAAGCAGCTCTCACCAAGCTCCTGCCCGGCCGACTGCGACCGTTGTTCTGGGCCATGTACGGATACGGCCGGCACATCGACGACCTCTCCGACACCCAGCACCTCGACCGGCAGGAACGAGTCGAACGCGTCAGCCGATTCAGCGAACTACTGGAGGCCGACCTGCGGGCAGGCCACAGCGAAGACCCCCTGCGCGCGGCCTTCGTGCACGCCGTATGGACCTGGGACCTGCCCAGCGACGGAGTAACCGCACTCAACGCCGTATACCGCCAGGACGCCAAAGGCCAGAGCGCCATCACCACCTGGGACGACTGGTACACCTACTGGCGCACCCTCACCTTCCCCTTCGGCGTGAGGCGCCTGATGGCCCTGCTCACCACCCCCGGCTTGGCCTTCACACCCGACGACGCCCAGGCACTGCGCGTGTGGACCGACGCGCTCAACCTCATCGACGTGCTGCGCGACCTACGGGAAGACGCCGCGGAGGGCTTCGTCAAGCTGCCCGCCGCCGTGCTCGACGAGCACGACGTCAGCCCTGAGGCCCTCGCCCACGGCCGGGCGGACGGCCGGTATGCCGACATGGTCCACGCCATGACCGCCAAGGCCCGCCAGTGGCTGGCTCAGGCCGCGACCGCCGGCGCCCAGCACCCACCCATGGCCGCAGCCCTGCAAACCGTCATCGACCTGCACCTGCTCGAACTGGACCGCATTGACCGCAAACCCCACGCACTGCTGCAGCGCCGCTCACGGGCGAACCCAGTCCGCTTCCACCTCACACTGGCCCGCGGCCGACTCCGCACGGCCAGGGCCTGGCACCGCCACACCCAGACCACTGCCACCACTCCTGCCACCATCCACCTGCCGCACCCCGCAGAAGGCCACCACGACACAGCGCGCACGACCCCTCCGCTACCACCGGTGCCCCACCCCAGCGGTGTCCAGCCGCCCCAACTGCCCGCCCACCTGGTCCCCCGACACGTGGCGCTCATCATGGACGGCAACGGACGATGGGCCACCCACCGGGGCCAGCCGCGCACCGCCGGCCACAAAGCCGGCCAGCTCGCGGTGCGGGACGTCATCTACGGCGCCCTCGAAATCGGCCTGCCCCACCTCAGCCTGTACTCCCTGTCCTCGGAGAACTGGGCACGCCCCGCCGCTGAGATCCAGGCCATCCTGCGCCTGGTCCGAGACGGCCTCGTCATGGAAACCGAGGAAGTCTGGCGACGCGACGTCCAGCTGCGCTGGTCCGGCCTCCCCGAAGGACTGCCACCGGACTTGGTGCACGCACTGCGCGAGACCGAACACCTCACACGCCACCGCACCGGCCTGACCGTGAACATGTGCATCAACTACGGCGGCCACAGCGAAATCACCCAAGCCGCACGCGAACTCGCCCGTCAAGTCGCCGCGGGGACCATCCAGCCCGACGACATCACCCCCCGCCACCTCGCCGCCCACCTCCACCACCCCGACCTGCCGGACGTGGATCTGCTCATCCGCACCGGCGGCGAACAGCGCACCTCGAACTTCCTGCCCTGGCAGTCGACCTACGCCGAACTCGTCTTCCTCGACACCCTGTGGCCGGACACCGACCGCACCCACCTGTGGCAGGCCATCGACACCTACACCCGCCGCGACCGTCGCTTCGGCACCACCCCCTCCCCACCCACCAACCCCGACGAACAGGCCCTCACCGGGTGATCTTGCGTGACCCGTACCGGCCACCCTGCGCACTTCGCCGGCGAAGCCACGTTCGAGAAAACGCAGTACTCCGACACCGCACGCAGGCTCTGCACGATCGGTGTCAGGTCTGATGTCGAGGCGGTGACGCGGGTCGTGGACCGGCTGGCGAGGACGCCGAGGGCGAGAAGGGCGGGGTCGAAGAGCCGGGAGGCCATCTCGACGTAGGTGCCAAGCCCTCGCCCGCTTTTTCGGGACGTCGTTCCGCGACGCTGCCTGGTTCGACAGGACACAGTTCTCCGAGTTCGAGTTCAGCGTCGCCGTATGTGCGCACCGGAGCAGGTCCATTGTGCGCCCGCTGCCACCGGGCGGCCATGGCCGAGCCGTGCAACGGCGTGCCATCGCTGGGCTGCGGAGTCGGAGATGCCCAGCAGGTCGGCGAGTCCCAGATCCTGCTCAACACCGTGCACGAGAGCGCCGACCGGCTGTTGCTGCGGCGCAGGCCGTCCTGGCGGGAGCGGAGGGCGGCGGGCAGCCGGCCGCAGTCCGCGGACACCAGGCGGTAGACGGTGCTGCGGTCGAAGTCGAAGCCGTAGCGGCGCCGGTCGGGGTCCAGGACAGCGAGCGCGGCACGGATGGACGCGCGGGTCTTAGCGCTCGAGGCCGACGAGGGGAAGTCCAGGGCGAGCACTGCGTCGTCCAGGTCTGCGTCGGTCATCGGCAGCGTGTGTCCGCTGCGGTAGAGGGCGACGGCGGTCGCGGTGGTAGGCGATGGCCTGCCCGGCTGTGACGTCGGTGCCGAGCGCTTCACGCGCGGTGGGCGGCAGCTCTGCGATCCCGGCGGAGAAGCGACGGGCGGGAATGCGCAGACGTGTCGGTCGCAGGGCGCGGCGCAGCGTGGCAACTCCTCGGCCTGGAAGGGGGAAAGGGGACCATAACCTGGCGAACAAAGCGAGAGAGGCGGGGCCCCTTCTTACCGACTCGCCCACACCCGGAGCAAGGCCGGGCGGCCGGCCGATAGCTGACCACAGGGGGCACCGACGGCTCTCATCTGCGTATCTCGCACGATTCCCTGCGCGAGCTGCGCATTGCGAACGGATCTTCGTTGCCGAGGACGGGTGTGCGAGGTGACAATGCGTGGAGGTGTCGGGTGGTCTCCCGGCGAAGTGGTGGAGGCGCTGCTTGTGAACACCGCATCGCGGTGCGCCTCGCTGTGCGCGCCAGACGCTGACCACTTCGCCTCGCTCACCAGCTGACGGGTTTCGTTCGCGGTGGGCGCTTGCCCTTATGGGAGACCACCGTAGTGCCTGAAGACTTCAGGCCGGTTGATCGCCGTCCTCTGGCAATGGTTCTTGCCGCCAACCTCCTTTCGGTCACTGGGAATTGCCTCACGTACATGGGCGTGCCGTGGTTCGTGCTGCAGAGCACGGGCAGTGCCGCCAAGGCCGGGATCGTCGCATTCTGCACACTGCTGCCCGCCGTGCTCGCTGCGCTCGTCACCGGCCCGGTCATCGACCGGATGGGGCGACGGCGGGTGAGTGTCGTCTCCGATCTCGCCTGTGGGGCCGCTGTTGCGGCGATCCCGCTGCTGCAGTTCGCCGGCATCCTGCAGTTCTGGATGCTGTGCGTGCTGATGGCGATGACAGGGCTGTTCCGGGCGCCGGGTGAAACCGCTCGCGGCGTGCTGCTGCCCACGCTCGCCGAACGCGCCGGAATGCCGCTGACCAGGGCTGCCGGGTTGTATGACGGTGCGGCACGCTGTGCGGCGCTGACCGGATCGGCTCTCGGAGGTGTGCTGATCGCTGTACTCGGAGCCGAGAACGTTCTGTGGATGGATGCCGCGACCTTCGCTGTCTCCGCGCCGCTGTTCGCGTTCGGGGTGCGCGGCCTGCCCGCGGCACAAGCCCAGCGGCAGGTCGAGGCGACATCGTTGCGTGCCTACCGTCGTGAACTCGCGGAAGGCTATCGCTTCCTGGCAGCCACTCCGTTGCTGCTGGGCCTGTGCCTGATGACGCTGGTCACCAGGGGCCTCGACCAGGGATGGAGTGCCGTGCTCCTGCCCGTGGATGCCCGTGGGCAGCTTGATGGTGCCGTCGATCTCGGTCTGTTGAACGCGGCGTTCGGGGTGTGTGCACTCGTGGGGGCGCTGGTCTTTGGGGCGGTGGGCAGCCGCTTTCGGCGGTGGCCCGTGTTCACGATCGCTTTTCTCATCGGGGGCCTGCCGCGTTTCGTGGTTGCCGCCTTCACCGACACCTTCGCCCCGCTGGCCGTGATCATGGCGGTTGAGGGTCTCGCTTTCGGTGTGCTCAGCCCCATCATGGCCACCGTGACGTATGAGGCGGTGCCGGAGGAACTGCGCAGCCGCGTGTTGAGTGCGACGACGGCCTCGGTCCAGCTGATCACTCCGATGGGCGGACTGGCTGCGGGTTTCCTCGTGGATTCGGCCGGCCTGCCCTGCACGCTGCTGTCGGTGGGCGGTGTGTATCTGCTCGCCACGCTGTGCCCGTTGATCTTCCCGGTCTGGAGGCAGTTGGACAGTACCGGCTCTGCCCACGACAGGGCGGCGAGCTCGCCGCGTGTCTCGGGATCGAAGCAGGTGTAGAGGCGCGGGCCTGCGCCGCGGATTGGGATCCCATCGACTGTCTTGATGACGGCGACGGGCTCGGTCCAGATCGCCGAGAGGTGGCGGCTGAGGGCCCGCTGATCGGGGTCCTTCTGAGACGGCACCAGGGGCGTGGAGCTCCCTGAGTCCGCGACCGCCCGCGCAGGGGACAGCACCGTCCCGGTCGACATGACGAAGTGCCTCCCGGCCGGAAAGGCCGGTGGTCATGCCCCTGATCCGCGGTCTGTCAGTGCCTTCGGCCGGTAACCAGTTGCGGGCTTCGAAGACGGTTATGGGGGCACTCTTCGGTCGGGGTTAGCTCTATGCGCGCGGGGCGTGGCGTGGGAGACAGGCTGTCGGTGTGCAACTGACGATCACCGGTTACGCCTGAGTCGTGGTCTTCTGCTTGAGGCGTTCGTAAGGTGTCTGGCCGCCAAGGCCGCCGTGCGGGCGATGGTAGTTGTAGTAGTCCTCCCACTCACGCAGCTTGTCGTTGAAGACCTCGGCGTCGTCGATGATGACGCCCTCGAGGAGCCGGTAGAACTCCTCGGCGTCGATGCGGTGAGAGCGCTCAACCTTGCCGTTCAGGCGCGGTGTTCGCGGCTTGATGTAGGTGTGGGCAATGCCCTTGTCCAATACGTGCCAGTGGAACGCAGACTGGAACTCGGCGCCGTTGTCCGTCTGGATGACCTCGACCTGGAACGGCAGGCGCTGGATGACGTAGTCGAGGAACTGGATCGCGGTCGCTTGGTTCAGCGTTGGGTAGATCCGCAGGACTCGCAGCCGGGTGCAGTCGTCGATCGCGGTGAACTGGAAGTACTTGTTGCGCCCACCGCGGCGGCCCTGAGGCATCGAGGCAAGTGGTTCGATGAACTTCACGTCGATCTGCACCCGATGGCCGGGCAGCTTCTTCTCGTACCGCTTCCATCGGCGGTCGTGGCGTTTGTACCGCTGAGAGGCCGGCAGACGGCCCATGTCCAGGCGGTTCAGGATCCGCCACACGCCCGACTTGCTGATCGTGACGTCGTGATACCGCTTGAGGTACATCGCGATCTTCTCTGGCCCGAAGTGGTAGTTCTGCCGGAGGTAGATGATCTTCCCGACTACCTCAACGTGGGTGGCGTTCGGGCTGTGCTTGGGGGCCTTCGAGCGCGTGCGCAGCCCCTCGATGCCCTCGGCTTGGTAACGGCGGTACCAGATGTAGTAGGCCTGCCGACTGATGCCGAAGTACCGGCAACTCATAGCAACGTTGCCGGTGACCTCTTCGACATGGCGTATGACGGCCAGGCGCCGCTTGGCCTCGCGATCGAGCGGGGTTGTCTTCGACATGTGGATCTCCGTAGGCGTCGGGAGACCCAGGTGTCAACGATGGTCGTCAGTTTTAGACCGACAACAGGCACCGGTTCGGGCGGGGTAGGCGCTTGGCCCGAACCGGGTCTGCCCATCGGCCTGATGGTTCAGCGTTCCCGGTCGTGTGGTGGGCGTTCCCGGAATTTCCAGGTGGTGAACAGGCCCATCCCGGTAACGCTGATGGTGGAGAGGGCGGTCGCGCCTCCGAGTGCGTAGACCAGCAGGGACAGTCCTGTCAGGCCTGTGAGGGCGGCCAGGTCCAGCAGCCGGTCGCGTGCGGGGGCTGGTTCGGTGGGCTCGTTTTGGTCCATGTCGGCAGTTCAGCAGCCGGGGGGAGTGGATGGCGAGTAAAGGGAATTCGGGAGAACGAACCCGAACACGGCGCCTGTGACGCCGAACGTGAGCGAATTCTGGCGAACACCGCGGGTGTTCCGCGTTGTTCAGGGAGTCCGGGGCAAGGATGGCATGCGCGTTTTAGCATGGCTGTCACGTGGTGTGAGGGGGAAACTTGGCTACTCCGATCTATGGCCCGACGGAATCGGCGGAAGAGGTGTACCAGGCGGCGCAGGCCGCTTTCGCCCGGGATCTGAAAGACCTGCAGCTGGCCTGTGACATCACCTACCGCCAGATCGGGGATCGCTCGCCGATCGTGTTGTCGCCCTCCGGGATCGCCGAAACTCTGCGCGGGAAGCGGCTGCCCAGCCGGGACTTCCTGAACGCCCTCGTCCGGGTCTTGTACGAGGTGCAGGACGAAAAGCCGGTCAGTCGTGAGGATCCCCGCCTGCGGCGATGGGAGGAACGGCGCACCCGTGTGCTGCTGTTACGGGACAGGGCCCGGCAGTCGAACCCAGGCGTAGGTGACCCAGACACAGGGCCGGGAGACTCGTTCCCCACGGACACCGGGTACGTTCCTCCGCCGGACGGTGCGACGCTGCTGGAACTGGAATCGGCCAAGTCGGATCTGCGGGACATTCTGAACAATCTTCAGGAACACGAACAGCGAGTGCGCACGGAGTTCCGTCAAGTCCTTGATGAGCAAGCTCGCGTGGCGGCGGAACTGAGCCGTCTGACCTCGCTCCTCGAACAGGAACGGGGCGACAAGGAGCGACTGGAACGCGAGGTCGCCTCGCTGAAGCGGCAGCGTGCGGTACTGAGTGAACAACTCGACGACCTGCGGGCCCAGTTTGCGGAGATCGATGCGGATAAGGTCGCTCTGCTGAAGGAGGAGAGCGACCTCAACGACCGGCGTGCCGTGCTCAACTTCGACTGGGCCCGCTACGAGGAATTGCTCCGTCAGCGGGCGAACGCCGAAGTGATGCGGCTGCGCGAACAGCTACAGCGGACGCTCTCGGACCCACCTGCCTGATCGCCGATGGCGGTGCGGCACGGGGCTGTGGTGGGCGGGCGCTGATGAAAGGCCGTGGCGCGGCCCTGTGCCCGGGCTGGCGGGCAGGGGTGCGGCATCACTGGGGTCGGGGCGGGTGGAATGTCTGGGCCGTCAAGTCGGCCGCGGGTGAAGCGGGCGCCCCGGGCGGCAATCGATCGGCAACCACCTCTAATCACCAATAATGGTGTCTTCGAGGGTAGTGTGAACCCTCCCTCTGAGCTGCGGCTCCTACGCCCGTGACGCCTGGGCGAGTGCGGCCGGCATGGCAATCACGGAGCTGGGGCGCCCGGACACTTCGGCCTGCACTCCCTCGGATACTCACCGAGGGCATGTGATCCGGCATCGCGCGGCCCTGAAGGCTTGGATGCAGATCAGGCGGCCTGCCAGTACGTGAATCCGAGGGACGTCAGCCCTTCGGAGCGGCAGAGGCGGTCTGAGGCGCCTGCGACCTCGGTTTGGAGGAGCTGGTATGCGGCGCCGTTGACCTGCCCCCAGTACATGGCGGCGCGCCACAGCAGGCGTCCCAGCCCTTGGCCGCGGTGTTCGGTAAGGACGCCGAAGTACTGGGGCATCAGTTGTGGGGTGCCGATCGCGTCGGGTCGGATCTCCATGGGGCCGATGGCGCCGGCTACCCGGCCCTTCGCGACGGCTGTCAGGACGGGGCCGACCGCTTTGGCCTGCATCTGCTGGTGGAGGAAGGTGAAGCCGTCGGCGGCCATCCGTTGGGCGAAGCCGGCGAAGGTGTCTTGTACGCCGGCCGGCCACTCATGCAAGAGACGGACAGGGCCGTCAGGAGCTGGGCAGATGGCCGTCGTGAAGTCCTGGAGGTGGATGCGCGTACCGCGCCCGTCCGCAGCTTCCGGACCGAGGAAGCGCACGATCCGTGCGCTCGCCGCCCCGTGTTCGGCGGCTAGTTTCTGGGCCAGCTCGGTCGCCGTGAGCGCGCTGCCGGGCTCGGTGCCGTAGAGGTGGACCTTGATCGTGCCGGCGCCGCGTCGGGACAGTGTGGGAATGAGCGTGTCGCCGGGTTGGTGGGCGATGTCCTGGACAAGGACGGTCTCGTCCTTGCTGTCGGACCAGCGGATGTCCTTGTCGTAGCGCAGGAACCAGCGCTCGGTGGAGGCCGCGATCAGGGTGTCCGTGAACAGGTCCTCGGTCAGGACTGACGGATGGACCGGCCCGATGGTGGGCACGTAGGGCGCCAGCACCACTGGACGAAGCCAGTCCCAGCGGAATCGCATGTGCTTAAGGTACTCATCTCGTACTCGAAGGCTCAGGTCCTGACGCGATTGCGCCAGGACCTGAGCACGGGTGACCGGAAGAGTCAGTTCGGGTTGTCGTCGCCGGCCGCGCAGGAGCAGGCGCTGCCCTCCATGAGGGCATCGGCGTCCGTTTCGATGACGACCGCCGTGGTCGCGACGAGCGTGGCGGACACGGTCGGGCGGACGACCGGCGGGCGGCTGGTGAGGATCTCGACGGGTACGGGACTCATGCGTGCACCATCTCCTTGGTGTCTGCGTGCTGGCAGTAGGCGTTCAGTGGTGCCTTCGCCTCCTGGTAGACCTTGGCGAGCGGTCGGCACACCCGGCAGGAGCCGGAGAGCGAGCAGCCCGAGCAGCCACCGGTGCGAAGCATCAGCCGGTCGGAGATGGCTCCGAGCCGGCGAAGACCGTCGACGCCTTCGGCCATGAGGTCGATCTGGTCATCACGGCCGATCTTGCAGATCGAGACCTTGGCGTGGGGGTCGGCGTGGAAGAAGGTGACGCCGGCGTTGCAGCCCTGGAAGACCGGTCGCTTACGCAGGTGCTCCGTGGACTGGACGAGCAGGGGCTCCCCGGTGCCGGAGAAGGTCGGCTGCATGTTGGTGTAGACGTGGTGATCGAGGCCCCAGCTTTGGACGAGGGCGACCATGGCGTCGACCTCGTGAGCGTTGTCCTCGGTGACCACGACTGAAACCCGCAGGGACAGACCGGCGTTGCGGGCCGCGACCATGCCCTTGTGGAAATTCTTCCAGGCGCCCCTGCGCTGGGTGAGTTCGTCGAACGACTCCTTGGTGGCGCCGTACATGCTGACGACGATGCGATACGGCGGGCAGTCACGGAACAGTCGCAGCAGCTTGGGCTTCCACAGACGCGAGGCGTTGGTGGAGACCGTGAGCATCATGCCCTGGCGGTAGGCGTACCGGTACGCGCCCTCGAAGTCGGGGTCGACCGTGGGTTCACCGCCTGTTATCTGCAGCCACAGCACTCCGGCGTCGCGGAAGATGTCGATGAGCTTGACCTTGTCTTCCCAGCTGAGGCCAGCCAGAGGGCGTTCGCCGAGGTAGCAGTGCTTGCAGCCGAAGTTGCAGTAGAGGTTGATCTCCCAACTCGCCCGGGCAAAGCCGAACTCGGTCGGTTCGCGTACCAGGAGCGCCGAACCGGCGGTCTGACCGTTCAAGTCGAGGCCCCAGGCTTCGGTGGCGGTGGTTGCCAGCCAGTCGGGTACGTGGTCGTCCGTCTGGGCACGGTGCTGTATGTCCTCGTAGCGCTCGGCCGGCAGGCGCACACAGGTGGCCCTTCCGGGGCGGACGGCCAGGTAGCCGTCCAAGAACGGGCTGACGATCAGCTGGTGCATCCGATACCTCCTGGGGCTTAAGCCCCCACCCCGGCTCGCACAGGGGAACCAAGCCGGAGCGGGAGCTGCACGGCAGGACGCGCGTCCCGCTGCTGGTTGTAGGAGCAGACGACGTGGCGACACCACTCGCAGCAGTCGCCACACGTGAAGGCGGGGGTTTGACAGGCCGCCTGCCTCGACTGGGCCTATGAAGATCACGAGCTGATCGGGGCGGCGGCAGAGCAGACATGTGCCCTGGAGCCACGGGCGAGGGGTCATGCCCCGGCCTCGATGCGCTCTTGGCGAGTCCGTGTCACCACGAGCTGGTCCGGTTTGTCGGCCGGCCACTCGGCACGAGCTGCGGCCCGGAGGATGGGCACGCCGTGGCTGACGTCGGTCACGATCGCTCGGCATCCGGGCTGGTACTCGACCTCGTCACCCACGCCAGGCAGCCTTGTGTCAGTCATCGTGGCACCCCGCCGTTTCGCTCGGTGTAGACCCACATCAGGCGCCGGGTGAGGTTGGCTACGTCGCGCATGTAGAAGAAGGCTGTGAAACTCGGCGTCTGTCTGCCGGGGCGGTTGGTCAGCTCCAACAGCTTGTACGCCTGGCGGAACAGGTCCATGCCTTCGTCATCGTCATCAGCGCCCCGGTCTTCGGCCAGGAGCAGACTCAGGAGACCGACGACCCTCGTCGTTTTGAAGTCGATGTCCTCTCGGGTCGACGTGCTCAGCTCCATCTTCAGCACGTCATCTGTGGTGTCCGAGAGCAGCTCCACATCGACGGGCAAGCTGTCGATGCCGGCCTTGGGTTCCTCGCTCACGCTCGCCACCACGCTTCTCCCCTCGACGCTGCCTGCGCGGACTTGGGTTCGACAACGACCGTAAGGCGGCCGTCGTCCAACTCCCAAGAAGATTGCGCGAGTTTGCAGCAACCCGATTGACGGCACCAATCAGGACGTCGACGATCGCTGTGTCGCGCAATTCTGCGCAAGATAGCGGACGGGAGAGCAACCATGAAGCTACGGTTCCTTGGTAAGAACTCCACCCCCGGAGACAGCCCCACCCTGTACGCCAGCGACCAGGACAGCTACGTCATCCAAGGCTGGAAGGTCTTCGCCAACGAACTGCTCATGCAGCTCAACGTGCCGGAAGGACAGGCCGCTATCGAGGTGCCAACCGAGCTGTTCGAGCACCTCACCAAGGACGGCCAAGTGTCCGGCGAGATCAGGAAGTTCACGGCCCCGATCATGCTCGTCACGGAACAGGGCACATGCGTGCTCCAGGGCCCGGAAGTGCACGATCCTGAAGCACTGAGCCAGATGCGCATGCCCGACTATGAGACCTGCATCGAGGTCCCCAAGTCCTCGATCACGGCCCTGCTGGAGGAAGACAGTGGACCTGATCACCCCCGCGCAGCGTGACGAGCTGTTCAACGACTTCGAGCGCGACGCCTTCCACCTGGAGCTAAGGGACGACTACGGGTCTCCCATCGAGGACACGCCGTATGCCCGATGGCAGCGGGGAGAGCCCGACGACTACACCTGGCTCGATCCATGGATGACGCTGATGAAGCGCGTCACTGGCCAAGGCAAGAGGGTCCGCCGCGTGCGGGTGGTTACCGAGCCGCACTCTCAGTACGTCGGGTGGGAGCACTCGCTGACCCACCTCAACATCGAGGCCGGCGAGGACATCCGCTGGTTCCCGCGGCACCAGCTGCCTGAAGGCACCTTCTTCCCCCTGGGCGGCAACGACTGGTGGCTCTACGACGACCAGCTCCTGGCCGTCGGCCACTTTGATCCGGAAGGCCGCGTCCTGGGGTCGGAGATCATCGAGGACCCCGACACCGTTGCCGAGTGCGTTCGTGTGCGCGACCTGCTCTGGGCCGACGCCATCCCGCACACCGAGTACAAGCCCTGACTCATCAGTGAGTAACCAAGCACAAGAAGCACGAGAGGTACTGGGTGCCCGGCTGCGCGGCTTCCGGAAAGACGCGGGGTTCGCGAGCGGCCGGGCATTCGCTCTGGCCACGGGGTGGGCAGAGTCCAAGGTGTCTCGGCTCGAGAACGGCAGGCAAAACCCCAGCGAGGATGACATCCGCGTCTGGTGTACCAAGACCAGCAGACCAGAGCACATCCCAGACTTGATCGCCACGGTGCGCCACATTGACGAGCTGTGGCTTGAGTGGCGCCGGCAGCTCCAGACCGGGGCAGAGCAGCGGCAGAAGAAGGCCCTGCCGGTCTACGCCAAAACCAAGGTCTTCCGTATCTGGCACCCAACGCTGGTGTGGGGAACGCTTCAGACGGTGGAGTACGCGGCGGAGACCTTCCGGCAGGTTGTTGACTACTACGAGATTCCCGACGATGCCGAAGCCGCCACGGCCAAACGGCTTGAACGGCAGCAGTACCTGTACCGAGGCAATCGAATCTTCAACGTAGTGCTCGGCGAGCAGGCGCTCTACACCAACTTCGGAGGACCAGAGGTGATGAAAGGGCAGCTCGACCGCCTCCTAGCCGTGATGCGCCTTCCCCGGTTGAGCCTGGGCATCATCCCCCGGTCCGCACCCGTGGGTATCTGGCCCGGCAACTCCTTTTCGATGTTCGACGACAAGCTCGTCCTCGTCGAAACCTACTCGGCCGAGTTCTCTGTCACGCAGCCCCGAGAGATCGAGCTGTACGCCAAAGCCTTCGCCCTTTTGAAGCAGTCCGCGGTCTACGGCACTGCCGTCCGCGACCTCATCCTCACCGCCAGCCAGCACTTCGATCAGATGCCGAGCGACTAGGAGAACACCGTGCAGCCTGTGGCCCCGAACTGGCGGACAAGCACCTACACGGGTACAGAGAACTGCGTTGAAGTAGCCGACAACGACCCGACCATGGTGATGGTGCGGGACACGAAGGCGCCCAGTGGCGGCTTGCTGGCCGTCCAGCCGACGACCTGGGTGGCCTTCGTCGAGTTCGCCAAGGCGAAATAGCGGTGGGCTGCCGCGAGGTTGCCCTCATCGGCACCGTACAGACCAGCTTCGGCGCGGGCGGGCGGAGCGAGCCGGGAGTCGCGACTTGACTCCTTGAGCTCGGCTCGCCCCAGAGCGAACGCTCGGCGGCGCGGTATGGCGGTGAGCGCTGGCCTCGACAGTGTTCTCCCGCTGGTCCGTGCCGCCCGTGAGGGGCTCACGGTGCGTGAGGTCGCGGCACAGATATAGGCCTGGACGGGCTGATCCTCTCGTCATGCTGGTTCGCCTCTCTGGGATGCGGGGGGTAGGGGACCGGCCGGGGCTTGCAGGTCAGCAGCCCCGCCTGCATGGCGGCCCGCACGTCAGCTCCGGAGGGCGTGGCCACCTACAGCACGGCGCGAATGCGGGAGAAGGGCAGGAGCCGGAGTTGAGGGCATGTGCGCGCACGGGACGTCCTTGCGGATGGATGTGGAGGTGAGGGGCGGTTCAGGCGAGGGGGCTGAGCGGCGGAGCTCAAGACGAGAGCGTCCCAGTGCTGCGCTCGTATTCCATGGTCCGCGTCTATGTGAAGGACCGCCGCAAGGAGGTACGCCGGCAGGCGGGGGGGCCCGGAGGCGATGTTCGTGCCGCAGACCCATCTGCCAGGGGCAGAGGCGGAGGTCGACTGCGGCGACGTGCACGTCATGCTCGCGGGCAAGATGACCAAGGTCTATCTGTGCTCGATGCGGCTGTCCTACTCCGGAAAAGGCGGTGCACCGGGTGTTCGCCTCCTGCGGCCAGGCGCAGGTCGAAGGCCCCAGCTCCTTGCCCGTGTGCCGCTCCGCGCTGCTCTAGATGTACTGCCCAGGCAGGTTGGTCGAGTTTGTGCTCTGACACCGTCTGAATCGGATGACGGGTGAAGGCCTCCGGTTGTGGAGTGGAGCTGTCGAGGAACCGCTCCGCCAAACAGGAGGCCTTCGTGTCTCACGCTAACGCTGCTTTGACGCCTCGTGCCCGTCTGCGCCTGGCACGTCTGATCGTTGATGACGGGTGGCCCGTCGCCCGTGCAGCCGAGCGCTATGACGTGTCCTGGCCCACCGCCAAGCGGTGGGCCGACCGTTACGCCGAGTCCGGTGAGGAGGCGATGCTCGACCGGTCCTCACGGCCCCACCACAGCCCGCCCGGACCCCACAGCCGCAGGTCCGCCGGATCGTGCATCTGCGCTGGAAGCAGCGGCTGGGCCCGGTCCAGATCGCCGGGCGGCTGGGCATGCCCGCCTCGACCGTCCACGCGGTCCTGACCAGGTGCCGGATCAATCGGCTGTCCCACATCGACCGCGTCACCGGCGAGCCGGTCCGCCGTTACGGACACGATCACCCCGGCGCGATGCTCCACATCGACGTCAAGAAGCTCGGGAACGTGCCCGACGGCGGCTGGCGTTACGTCGGACGCGTCCAGGGCCGCACAAACCGTGCCGCAACACCCGACAGGCCCCGCAACAAGTACCGCGGACCGCTGCTGGGGACCGCGTTCGTGCACACCGTCGTCGACGACCATTCCCGCGTCGCCTACGCCGAGATCTGCGATGACGAGACGGCCGCGACCGCGGCCGGTGTTCTGCACCGGGCGGTCAACTGGTTCGCCGCCCGCGGGGTGAGCATCGAGCGGGTCCTCACCGACAACGGCTCGGCCTACCGCTCCCGGCACTGGTCCCGGGCCTGCGACGAACTCGGGATCACACCGAAGAAGACCCGGCCCTACCGGCCGCAGACGAACGGCAAGGTCGAACGCTTCCACCGCACCCTCGCCGACGGCTGGGCCCTGGGACGCTTCTACGCCAGCGAATCAGCCCGCCGCAAAGCCCTGCCGGCCTGGCTCCATCACTACAATCACCATCGCCCCCACACCGCGACCGGCGGCAAACCACCCATCACCAGGTTGACCAACGTCCCTGGGCAGTACATCTAGACGGACAGGGCATGCTCTGCCGTCTGCCGCGCCCGTCGCTGCCGCCGATTACCGGATACGGCGGTTCGACGGCGGAGGGCTGGAGCGCAGGCCCAGGGGGAGAAGGGGAAGCGACCTGGTGCTGCAGCAGCGGCGCTGGATGTCAGCGCAGGTTGGTGAGCCAGGTGACCTTGGCCGTCGGCGCAATCTTCTCGTTCACCAGGGTCTCGGTCCGCCGGTCCCACGCGGAGCCGGTGGTGGCCATCACGAACTCGTCCGCGCTGAGCTCGTCGATCAGGCCCTTGAGAGCGGCGCAACGCCGCGCTTCCTCACGTTTCGTCTGCTCGAGACGATCACTGATCTTGGCTTCGCCGATGACGATCCGGCCGTCGACGATGGCCCAGAGGTCGACCTCGAGGTCCGGGTATCCATCCCGGCGGACGACCGCTTCGGGCATGTACTGGAAGGAGCGCGCCGGCTCCGAGAGCGCCGCGAGCGCGAGGACCGGCACCTGGACGTTCGAGCGCAGGCCCTGGTAGGCGACCTCGTCGAGACCGTAGTACCACTGCGGCTCCAACTCCTGTCCCTTCCAGGCCGACCGGACGATCGGGTTGTGCTGACGGCAGCGCTGGCACCGGAAATGCGCTCCGATGTCCTCCAGCCGGTAGAAGGCCGTGCCGACACACTGCCCGCAGGTCAACAGCAGGCCCCGCGTCGCGATGGACCGCTGCAGGTAGCCGTCCAGCAGTTGCCGGGCACCTTCCTCGCTCCCGCCGGTGATCGAGCAGACATCGGCGAACGTAAGGTACTTGCGGTCCTGGTAGACGCGCCCGAGCTCTTTCCCGGCAGAGATCCACCCGGACAGCAGGTTCGCGGCGGGGCCCTCCTTGAGGTCGGCGGCCAGGGCCGCGAAGTCTCCCCACAGTTCGATCATGCGCCGGGTGTAGCGGCCCTTGTCGGACTCCTCCAGGGTGATGCCCGCCCCAGCCAGGAGGGTGCTGAACACCTGGCGGGCTGTGGGAAGCCGCAGCCTTACCTGAACCAGAAGTTGGGCCAGGGAGGTCCCGGTGACCGTGAAGATCCGGCCGTGGGAGTCGATGCTGATCCCGGACGTGCTGGAGCGGACTCCCCACGAGGTGCCGTCGGCGGTGATCACGTCGTTCAGCGCCCACCGCGCAGGAAGGACGGCTTTGGGGTCTAGGACGTCCACCTGCCACCGGCAGGAGTCCGGCTGGACCCCGGCCGCCTCGCTGGGCAGCGGGATCTCGACGTTCCGTGCCTGGTCGGTCCCGAGGAACGGCTCGTGCAGGGTGTCGCCGACGTGCGCCTTGTCGAGAAGGTGGAGGCGGCGGCACACCGGCAGATCCGCCGGGGCACAGACCTGTACGTCCAGCCGGCCTGGGGAGCCGGAGGCGGCCATCCGCCCCCATGGCGTGGCCACCAGCTGGTCACGGACTGCGTGCATCTGGTCCTCGCCGAGGGTGAGTGAGGACAGCAGGAGGGGACGGGCGGAGACCAGCGGTACCGCGAGGTCGTACAGGATCTGCATCAGCTCGGTGTGCAGCTGCGGGCTGAGGTCTTCGGTGTCCGGGCCGACCGGCAGCCAGTGCGCGTCTCCCACCACACGCTGGCGGGTGTAGGCGTAGCAGAAGTCTTCGGCGCTGTCCCCGCAGATGACCACCAACGGCTCGCTGTCCGCGTCCGTGTCGAACGTGGTGAACCAGGAGCAGCCCAGCCGGGACTGCGCCAGTGGCAGGTCGTCCAGGAAGTCCTGCTGGGTGAAATCGGCGCCGGTCTCAGGCCGGCCCGTCCACGCGTACCGCAGCACCTGGGCCAGGTCTTCCCGATGCACCGGAACGGTGGCATGGTCCACCTCGCCGCGCTCCCGCAGCCGCGCCAGATGCCCCGGAGCCACCAAGCCGGCGCGCGCGGCGACGAGCAGCTGCACCGCAGGCGGCAGCTCGTCCGCGTCGAAGCCGGTGATGCGCGCGGGCTGAAACGTCAGCCCGCACATGTCCACCAGCCGGTGCGGCGGCGCCTCGTCCGCGCGGAACTCCGCTGTTACCGTGACCTGCGCCGACGCCAGCGGAGCCATGCGCCGCCGGATACGGTCCCCCAGCTCCCGCGGCGCCACCATTCCCGCGCCGGACGACAGAAGTTGAGGCTCGAGCATCCGCCGGGCCTGGGCTTCGTCAACATCGTTCTCCCTGGACCAGCCTTCCACGTACGAGGCGAGCTGCGCCTCGTACGCCCGAGGGTCCGACATCTGAAGGCCCCGCCCTGTCCGGGCGAACACCGCCCAGTGATCCGCGTCGAAAGCCTCCGCGAGCCGCCAGAACGGCTCCGCGACCTCCCACTCGGGCGAGCAAGCGATCAAGCCGTGGCCGTCACCACCCCACGTGCGCGCATAGCACTCCACCATGCGCAGCACGTCCGCCCGCCAGTCCCCGCCCGAACACACCAGAGTCATGGCACGCGGGGGCCGCACATTCCGTTGCACCAGCCGATAGCCCAATGTGTTCGCTTCAGCCATCCCCGCCCCATGTGCCGCCCTGGCCCCGTCGAACCGACTTAGATCGACGTGGCATCTCCGCACTCCCGCGCCCCCTTGCCGAAGCCTACTGGGCCCACAGATCACAACTGGCCTGGGCGTGAAGTGGCCCGAGTGAAGACCAGGCCGCGGCTGCAGCTCACCCCCGGCCGGCAACACCCTCGCCCGGTGATCGCCTACTTCCTCCTGCACGACGCCTCGCTCGACCACCCGGGCCCCAGCGTCTGACACCGGCCGCCGGAGTCCCCACCATCGCGCACGCAGAAAGAGGCCGTCGATGGCTGCCCAGAAAACCGAACTCCCCGCCGGCCCGGATGCAGGTCCCGAGAAAGCGGACCGCAACCTTGCACTTGAACTCGTCCGGGTCATCGAGGCCGCAACCACCAGAACCAGGCCGACGCCTTGCGGACGGGAGTGAACGCCCGTGTCTCCTGACCAGCCCACCATCCCCGAGGACACCGACGCCACGGCCCGACGCTGCCCGGTCTGCGAAACCGTCTTCGCCGTCGCCAGCAGCACCAGTCGGCAGGTGTTCTGCTCACCCACCTGCCGCGAGGCCAACCGGCAGAAGATCCCCACCCAGATGACCTGCCGGTCTGCGCAGGCGAGTTCACCGCCTACGGCCGCGCGAAGCGCCGCGTCTACTGCTCTCCGAGAACGTCTTCGACGCCCCCACAACGGTGCGGCGGGTCTACTGCTCGCCCGCATGCCGCAAGGATGCCGAACGCCAGCGCGAGCATGAACGTGACGAGGCCCGGGCCCGCCGCTTGGGTGAGGCGCCGCTCTCACGACCGCAGACACGGCCAGAGTTCCCGCCACCACCCAAAGCCGTCACTCGCCCCGGGCGCCAACTCGTCGCCGAACGAGACCCGTTGGAGCCTACGGCAACCCGCAACTGCCCCCACTGCCAGCAGCCCGTCACCATCGTCGCTCTGCTGGCCACCCCAGAAGCCGCTCGTCCTCCCATGCCCACCGGCCCCGACGTCATCCCGATGCGGAGACTCCCCTGACACACGCATGAAGCAAGGCAAGTACGCCTTGACAATTTTGAATTGTCAAGGCGTACTTGCCTCATGGCTCTTCCGGACCTGGACGATCTCATCGCGGAAGTCGACCGCAGATGCGACACCGCACACCGCCCCGGCGGACAAGAACAGCCCGACTGGCTCGCCCTCCTCACCGTTGCCGCCCAACTCGCAGGCCAGATGCAGGCGCTGGCGGACGACTTGGTCGAGGACTACGTCGAGCACTGCCGCATGCACGGCTCTTCATGGACTGACATCGGCGCCGCCCTGGGCGTGACCCGACAGGCGGTCCAGCAGCGTTTCCACGCCCCGCACAAGCGATACAGCCCCGAGACAATGACCGACGACCTCCGCCAGGCGATGGTCCACGTCAAACAGGCAGCGGTGCAGCACCGCAATAACTACATCGGCACCGAGCACCTGCTCTGGGGACTGACCGCGGAAGACAACAGCGCCACCCAACTCCTGCAGACCGCCGGCGTCTCGTCGAAGACGATCCACCGGTCCGTCGGAACCCGGCTGAGCATGGGTGCCTCCCAAGCAGCCGAACGCATCGCCTGGACGCCCTACGCCCGCAAAGCCATCGCTATCGCCGAGGCACGGTCCGAGCAGAACGGCTCCGACCGCATCGACTGCGACGACCTGCTGATCGGCCTTGCCCAGGTCGGCCGCGGAGTGGCCGCCAACGTCCTGACCGAGGCCGGCTTCCACCCAGCCGCCCTCAACGCAACGACGGCGGACACCCACTCATCACAGAACGGCTGACCACAACCCACTGCACCAATTCCCAAGGGGCCGCCGACCTCATGGTCGGCGGCCCCTCATGGCTCGTACTCCCCAACCTCCGCACACCCTTCAAAACCAGATCAACTGAGGAGGAAGAGCAACTCTGGCCGAATCCAGGAAGTCCCATCACCCCGTGGGCAGGCGGGCCGCCGTCCCGGTCGTCCCCAGGGCGCGTTCTGGGGTGTTCCATGGCTGTACGGCTGCGGCCGATGTCAGTGGCGTGAGCGATGATCTCGGCCATGACTGCGACTGCTGCCGAGTGTGTGTGGTGCGAACGGCGGTTGGGTGCGGATCCTTTGGAGTGACGGTTCCCTCCTCGGGGATCAGTTCGTGGCATCCCATTCGTCCGGGGTCATGGGCTTGGCGTCCGGATAGTGTCGTCGGATCTCGTTGAGTACCCACTCGTCTGCTGTGCGGACATCCCAGCTTGAACTGTCGAACTCCCTCAGGGTCAGCACGAGCTCGCTACCCGCGTAGCCTTCAAAGTCTCCGTCGACGGCCTGCAGGTGGGGCGCGTCCATGGCCAACAGCTCGAGGGTGGGGATTCCGTGGCCGGCTGAAGCTCTGACCAGCTCCGCGAAGCTGGAGTGTGGGTGATCGTCGAAGATCCGGGCTCGCCACGTGAGCGTGAGGCCGTAACTCCCCAGGCGGATCAGGAGTTCGGCCAGGGTGACGTAGTGCCGATCGGCATGGTGGCCCGTATGCGGGGCAGTGTCCCGCCAGGCCGCAAAGGAGACCATCTGCATCGTGGGCGGTGTTTTGATCATCGGCTCAGCACCCTGCTCCGGTCTAGGGGAATCACTGATTGCACTTGCCTATTGTCCTGCTCTTCCCCTTCGAATGATCGATTGGGTGTAGTTGCTCCCGGGCGGGGAGAGCTGGGCAAACGCTGATTGGTGTGTGGTGGTGTCGTCGGGCTTCTACCGTGGCGGGATGGAGGTGGGGCGCCATGGTGTCTTTGCCGGAAGAGCTTCAGGCTCGAGAGGCCGCAGCTCGGCGGCGCGTGGAGGCACTCCAAGCTGAGGCAGCCGAGTTGGCCATCCGGCTGGAGGCGGCTCGGGAGGATCTTTCGCGGCTCGAGATCACGCGGGAGACCGTCGCGCAGGTGCTGGCGGAACTGTCGGCCGCTCAGGCCGGACCGCACCTTGCGGCGGGGGATGCTCCGGCGCCGGACGAGACGTCGGTGCCTCACGGCGTCGGGGTGATGATGGTGCCGCCTTGGCGGGAGGGCCTGGTGGTGGCGGTATTACCGGATGTCTACCGGGACATCGTGGAGATCATCGCTGACGCGCCAGGACCGCTGCAGGCCAAGCAGATCGTGCCGCGGATCGGTCTGCCGACGACGACCGGGAAGATCGAGGGCACCCGGGAAAAGCTGAAGCGGCTGGTGGAACGAGGCTGGCTGGACGAGAACACGCCGGGACAGTTCACCCTCGCCCGGCAAGGCCCGGGGCGAGACCGCAGCAACTCGCAGTGACCAAGGGGCTCTTCTCCGTAGATTCGTAGGTGCCAACCAAAACGAATCACTCCCGAAGAAGAGCCCTCGATGGAACCGTACGATGCCTTACCCGAGCCTGATCCATACTCCGCCTCCCGTGATGCCTTCGAACGCCTCATCTCGACGCTGGCCGACGGCCCGGCAGCAGACTTGTCTCACGACGAACTCGAAGCCCAGCTCGAAGAGTTAGGGCGCGAACTGCTGCGGCATTTGATGCAGAACCACCTCGATCAGCGAGCCAGGAAGGAGGAGGACACGATGCGAGCGGACCGAGGGCAGCCCCTGGTACTCGGTCCGGAAGGACAGCCTCGAACCTGGCGAGAGATGGGTCACCGCCGCCTACTGACGTGCGTGTTCGGGCCAGTTCGGGTGACCCGGATCGCCCATCGTGGCCGAGGCGTTGCCAACGTGCACCCAGCAGACGAGAAGCTGTCGCTGCCCGCGGGCCGGCACTCACGCGGCCTTGCCCGGCTCGCGGTCCTGGAAGCCGTGAGAGGCTCGTTCGACCAGGCTGCCGCTGCAATCGAGCGACGATGTGGGAAGGTGCTGGGCAAGCGCCGCCTCAAAGAACTGGTGGTCGCCTCCGCGGTCGACATCGCCGCCTACTACACGGCGAAGATCCCCACCCCGTGCACCCGCGAGATGCCGCTGGTCATCGAGATCGACGGCAAGGGCGTGGTGATGCGCCCCGAAGCCCTGCGCGAAGCCACCCGCCGAGCCGCGGCCAAGAGCGCGGCGGCCGGGCGACGCGGACGCCTGGCCCCGGGCGAGAAGCCCAACCGCAAACGCATGGCGACGGTGGCCTGCGTCTTCGATGTCGTTCCGGCCCCACGTCGGCCGCACGATATCGTCCACCCGCCCGGTGGCCGAAGCGAAACCCGGCCGCCACGACAGGGCCCGAAAGCGGAGCGCAAATGGTGCACCGCCTCGGTGATGCACTCTCCAGAACTGGTCGTCGCCGACGCCTTCGACCAGGCCGAGGCCCGCGACCCCCGGCATCTGCGGGACTGGCTCGTCCTCGTCGACGGCGCCCGCCACCAACTCGACCTGATCCAGGCCGAAGCCGACCGCCGCGGCATTCACCTGAATATCCTGCTCGACTTCGTGCACGTCGCCGAGTACACGTGGACGGACGCGCATGCCTTCCATCCGGTCGGCAGCCGCGAGGCCGAGACCTGGGCCGCAGACAAACTCACCGCGATCCTCGCCGGACACGCCGACCGCGCCGCCACCGAGATGACCGCCCAGGCCGCAGCAGAACAGCTTCCCGCAACCCGCTGCGACGCCGTCACCACCTGCGCTCGCTATCTCACCGGTCACCTCGACCAGCTCCACTACGACACCGCCCTCACGGCTGGCTGGCCAATCGCCACCGGCGCCGTCGAAGGCGCCTGCCGCCACCTCATCGCCGACCGCCTTGACATCACCGGCGCCCGCTGGGGACTCGACGGCGCCGAAGCCGTCCTCCAACTCCGCGCACTGATCACGAACGGCGACTTCGAGGACTACTGGCGCTACCACGCGGTGCGTGAACATCAACGCCTCTACCCCAGCCCCGACCCGCAGAACTACGGCCTCACCGCTTGATCCCGACGGTCACTTCAAAGGATCCGCACCCAAAGCCGATGGCATCCCGATACGACTCCACCACCGCCTGCGGCGGGTGCGCCATGCGGCTGCCCTGCCAGTGCACCTCCTGGCCGGAAGAGCCGGGCAGCACGGCGGTCAGCCCGTCGGCCGCTTCCGCTGGCGTGCGTACCGCGGGCCAGCTGCCGTAGACGTTGGAAACTTGTAGCGCCCCGGCCTCGTCGGTGGCCTGTAGTGTGCCGCCGGGGACCAGCAGCTGGCGGACCTTGTTGCGCTCGTATCTCTCTTCAGCCCATACGGGCTGCGTGCTCACGTTCATCCAGGTGCTCTCTGTTGCAGGTCCGGGCGCCAGCCCGTGGCGATGTGAGTGCAGAAGGCGAAGGGTTCACGACATCGGCTGATGCCAAGAGCCGTGCCTGCGGTTCAGCGGCGGTATCCGCGCTCTGGGGAGCGCGCAGGGACGTTGAGGAAGTCTTCGAACCAGTTGTCCGGGTGCAAGGCGGGCGGGACGCCGACAGGCTCCCTGCCCTCGGCTTCTCCGGCGTCTTCGCTGTACTTGCTGTCGTACAGCCACAGCACATCGTGGTCCTGGAAGAAGAAATCCGAGCAGGCGTCGAAGTCATAGTCGTCGCGGTGCGTGGGCAGTGCCGCATGCGGACTGCCGTCACCGGCTTCCAGATGCTCGAGGGCATCGTCGAGGGCGAGATGCAAGACCATCTCCTCCGCCGCGCAGACGGGCCGGGGCCATCTGCCGCTCGCGAGGTCGCCTGCCAGATCGTCGCAGGCCCGGGCCAGGCCGCGCCGCCACTGCGCGTTCTGGCGCCAGGTCACCTGCGGAAGACGGGAGAAGAAGCCCCAGGCACCGTCATCGTCCTTGATGACGGGACGATCACCCAACTCGGCGGCATCGTCGTAAGCCGACTCAGCAAGCTCGACCAGCGCGCTGTACAGCAGCTCGGCCGTGCGCGGCGTGAGCGTCCAGTCGCACTTGCGGCAGTCCTCCTCCTCGCAGTCGCACGCCGCGGGCAGCGCGAAGAGAGCGGCGAAGTCCGGCTGCTCCTGGTCGCTCTCGGGCACAGCGCCCGTGCTCGAGGCGGTGCCGGAGCGATTGGTCCGGTGCAGGCGCCAGCCCGAGCCGAAATCGACGCGGACCGGCTCAGCCGACCAGTCGGCGACCTCGTCTCCCTGAGCAGACAGCAGCAGTTGACCTTCCTGCGTGTCGTTCAGGCAGTCCGCGCCCGGCAGGTCACCCGTGGTCTCGGCAGCGAACATGACAGCGCCGGTCAGGTCGTGCGGATCCTCCTGGGTGAGCTCCTCCTGCGGCGCAGGCTCCCAGCCGCTGGCGGCCGCTGCCGTGAGTGCCTTGGCCTGGTCGTAGACGTGGAACTCGCGCAACTGGACCACGCGAATCACCGGACCGGGCAGGTCGGCGAGCCGAGCGTCCCTCGGGGTGCGGATAGCGGAAACGGGAAGTGCCTCTTCCGTGCCGCTCTCCTGCACCCAGTCGAACGGGTCGTCGGAAGGCCAGGTGAACCCCGGCGAGCCGGCGGGCCACACCCCCGCGCGTGCCTGGTCGAGAGCTTGACGGAAGGAGGCAGCAGGAGCATCCGGCAGCACAGTGAGCAGTTTGCCCGCCGTGTTCTGCTGCGGCGCGGTGAGGATCCCGTTGCGGGCAGCGAGGGAGAGGAGGAGCGCGGCATGCTGGGCCACGAGCGCATCCTTGCAGGTCATGACGGCCTGCAGGCTGGAGGGCCCGTCAGGGTGTGCCAGCAGAACGAGAACGCGGCTTTTGCTGGCGGAGTGCTCGCAGAAGAAGTCGCGGGGCAGCGCAGATGGGGTGGCCTGGACGGCTGTCATGGAGGAGCTCCAACGATGCGCGGCAAGCCGAAGCCCGCCGCAGTGAGAAGAAAGCTGCTGGTGGGCACGGTACGACCGCATCCCCGGACAGCGTGGAAGTCTGTTGCAGCTCGTGCCATCGCTACGAGCGGCGACCCGGGCCTGAAACGCGACTTTAGCCCCCGAGTAGCGAACAGGCAGGCAGATTCGGGTTATTTCCGATCGCGGCACGACAGCGCCCGCGCGCGGCGCGCTCCGCGACTGGTTCAGTCGACCAGGGACAGGCACAGCCGAAGCAGCGATGGCCTTCGCGAACGACGCTGCCAGCCGTACGGCTGGCAGCGAGAGCCGGGATGCTCAGGCAATGTCTCCCGGATTCCACTCAGGCGGAAGACGGCCAAGTCCGAGCCGGGCCTCGATGCCGAGGTGTTCACGCAGAAGGGCTTTCAGAGTTCGGCCGTCCACCAGATCGATGCGGCCGCTGCGTTGGGCGAACGCATGGCTGCTTGCCCCGAACCAGCTGGTGGTGACCAGGATGCCCCGGCTGGCCTGCACGTCCAGCATCTGCCCGGCCAGGGCGTGAACCGTCTCCAGAGGCACGACGTGCCGGTTGCGCCGGCACTGAAGCACCCACCGTTCGCCGGTGGTGGGCCTGTCACGCAAGACAGTGGTTGCTGGCCCTGGTCCGATCAACTCGCGGGGGCCGCCTTCAGTAGTGCCGTGCAGCTCCATGCAGAGGCGGTGGACGAGATCGTCCAAGTCCTCGGGGGACAGGCTCACCAGATCGATACGGTCGTCGGCGGCCGCAACGACGGCGGGACGCGGCGTGTCGTGTGCGAGGGCGGCCTCGTACCACTTGTCGTCGCTTTGATAGGCAGGATCTCCTTTGCGGAAACGCTCCGCCCATGCGGCGGCTTCATCGTGCAGGGCCTTTGCTCCGTCTCCGGGGATCAGGTTCCGCAGACCGGGATCGTTCCTGCGGAAGGCGCGGAAGAGGGTGGCCAGGGGACTGGTGTTGGGCGCGTATCCCAACCGCTGGGCGTGCCGGGGAGCAAGAGGGCCGGGGCCGCGCACGGCATGGACGACCGCACGCCATTCCGGGCTGTCGTAATCGAATGCCGTCTTGGTGAAGTTGACGGGCACGTGGTCACAGTGGATCTCACCGACCAGCCTGCCCTTCGCGGGCCCGTCCACCGGATACTCCACCATGGAGCGGTCAGGGCCATCCTCGAAGAAGAACAGGCCTTTGTCCCTGACGAGAACCTTGCGGCCGTTGCGATAGAAGTCGAGGCCGTAGTCACTGCCGTGCAGATAGCGCTGAACGCCCAGCCAGCCCCATACGCGTTGTTCCGTCAACTCGAGCTGTGTTCCCTGGCACTGCAGACAATGCGGTGAGCCAAGCGGACTGGTGTGACGGCAGTTCCGGCAGCGATACCGCGTGGCCAGCACGATGTCGAGGCGCTGCACGGCCGCGATGTTGCCCTCGCGCCGCTGGACAACGCGGTTCTCGCCCCAGATGCACGGCATGCGGGGAGCCACCGGCCGGTCAGACACGGTCAGCTGTACCTGCTCCTTGCGCAGCAGGTAGCTGTAAATGTCTCCCAGCTGATGCCGCAGACGGTTCTGCCTGCCCGGCGGCCAGGGGTCGCGCAGGGCTTTGATGGTGATGAACGTGCCCTGGTCCTCCGCCGCTGCTTTGGGTTCCGCGCCGATGAGCGCGTGCCAGGGGGAGCCGGCGGTAAGGGAGGCCAGATCGAAGGTGAGGACGGTCCATGCCGTATCGCCTGCCCGGGCGGTGCGCAGCGTGATGTGCGCACCCAGCTGCAGACACGCCACGACAAAGCCCAGGCCGAAGATGTCCTGGTCCTGCGTCCCGCCGGTCCAACTTGCCAGGAAAGCCTTGCTGATGGTGTCGCGGTCCATACCGGTGTGCCGGCACGAGACGGTGATCGTCTCGTGGCCGGGGGAGTCCGGATCGTGCTGGAATCCGACCGTGACCGCAGGGTGCTGCCCCGCCCCTGTGCTGCCTTTCATCACGGCGTCCACCAACTCGGCCACAGCCGCCCACTCGGCCAGCGGGATGTCGGCCAACGCGGCCAGCGCGGCCGGAGCAGGCACCAACATCAACGGCTTCGCCGGGGCCTTGAGGTCTCGTGCCGTACGAGCCCGTGCGGCACGAGAGTTGGTGTCGGCACGCTCCCAGGCAGCTGCCCAGGCTGCTGCCTCACTGCGTCCTACCCCCACGATCTCGGCGAACATCACCACCAGGTTCCGGCGGGGATTCACCGCTCCGCTCAGGACATTGCTCAAGGTGCTCCGCGTCAGCCTCTTTCCAGCCCGATCTTCCAGCTCACGCAGGCTCGGCGAACCTGCCAGGGCGCGCAGGCGGTTCATCGCTTCGCGCAATTCCTCGAAAGTGCCCACCTGCCCGATGGAGATCACATCGGGGCCCTGGTCGATCCCCTCAAGGGCGGCCTTCGCCTTCAGCCAGAGCTGTCTGGCCTCGGCTACGTCCGTGCCGCAGGCCCGGGTGAACGCCTCGACCACCGGCCAGGGGGAGCGCCAGCCGTGGGCTGCCCGGTTGAGTCTGCCCCTGCTGAAGCCCGTAGCCTGTACGAGGTCTTCGTACGTGAGGCCCGACAGGTGGCGCGACTGCCGCAGCCAGCGCGCCACCTCCGCCATTTCCGGCACCCGGGCAACAAGCTCCTTCTCCCGTCGCCCCGCCATGACATCAACCAGCCGTCACATGCGGTCGTGCGCCGACGGCTTCACCACGGCCACCACCATCGCGGCCACTACCGCGGCCACTGTCTCGGTGACGAGTACCTGCGCCGCGTCCTGCCAGGCCGCCGCCGAACCCAGCGTGCCGACCACCACGATCAGCACGGCAACGACCATCACGACATCGGACAGGTGACGCGGCACCGGAGCGCCGTCCCCGACACACAGCAGAGCCTTACTCATGCGTGAACTCCCTTGATGCACCTCGGACATGTGTGCCACTGCCGACGGGAGGTTTGGGGCCAGCCCGCCGCTGCACACATCCCAGATCCTGCCGGACCCGCCCCCCTCAACACCACCCGGAACCTAGAGTTCAAGGCATTGTCCCAACTGTGTCCAGAACAGGACTCCGATGCGTTCTCCCTGTTCAAAGGCCTCCTCCGGCTAGTCGGCACGAGGCAGAACAACGCTGTCCCGCCCGTGTCCAGGTTTCGAGTTGCTTCCTGCGGCCAGCCTGGGACACCCTGGTCGCAGGATCTGGGCACCTCGGACAACGCCGTGCACGGAACCCGGACCGCAGCGCATTTGGGGTGCGCCCGGTCAGCGGTGAGGCCGCGCGCCCAGCGCGCGGCCCGCCCGCACACCTCCGTGCAAAGCACCGTCTGAGCGCAACGGCGCCGCGTCTTCTCGAGCGCGGACGGCACACTGGGGATCATGACCCCGGTACAGATTTCCTTCGGCATCGGCGAACACAAAGACACCGCACGGCGTTGCTCCAGCGCGAGTGGCCCCTGACGGATCTGCCGTTCCCCGTGAACGAGCCGCAGCTCTGGACCATGATCTGCGTAGGCTCGAACGCCCTCGTCGGACTTGCCGTGGTGGCCAACGGATTCAGAGCCCCAGCGGTGTCAGCTCACGGCCCGCGTCCCTACCGCCCGCTACAGCCCGTCGACCTGCTCGACGAAGGTGCGTCGCCGACACGACGGCCGGTCACGAAAGAACCGCCGTCCTCGCAATCGGATGACCAACTGCTGTCTTCCAAGCTGGCGTTCGGCCAGTCCGCGCTCATACGCGGAGTGCGCGCCCTCCTCGACTGTGCCTGCAGCCCGGACATCGCGGCGGCGGACTGCAGGCACCGGCGCACCCCGTTCCCCTAACGGTGGATGAACCAGTACAAAACCGTGCCCGTGCCGGTGGCACCGCACGTGTACGCCGCGCCGGCTACGGCCGCCCAGAGCGCCTCGTGCAGCAGGCGGCGGGGCATGCGCGATGCGCGCTGCGGCCGGCCTCGGGTGCGGCCGGCCGCGCCCCCCTCGCAGCAGTGGGGCGCGCCGCAGCCGCACGGTCGGCCGGAGGCGGGGATGCACGGAGTCGTCGTGACCACGATGGGCTGAGGCTCGGGGATGCGCGCGAGCCGGTGGCCGCGGGGTGCTGGGAGCATGGAGGGATCTCCGCATCTGCTGAACTGACAGTGACAGGGAGATCCTGTTCGGCCCCGAAAAGGGCCAACAGCCCTTCAGACGGCGTGCATTGGAACGCTCTGGACACCAGTGGACACCGCCTCTGCGGCGTAACGTATGCTCATGAGGGTCACCGTGGCGACGCTGGCAAGGGCTCAGGGCCTGCGCGACGACTTCGACAGCCTGCAACGTCTGCGCCACGGCAGGGGCATCGCCAGCCCCGGTGATCTTTACTACCTGTCCGAGTTCGTCAAGCGCCGGGTGCTGTGTATCGAAGACGACACCGATAGCCAGCTCACCCAGGGGCTGGACAACCTCAAGAAGCTCATCGAGAGGGCACCGCCGCGTGAGCGGGAGCTGTTGAGGCTCAGTTTCAACATCGACGGCGCATTCGGTGACTTCAACTGGCTCGAACGAGTCGAAGACTTCGCGCTGGCGCACGAGTGGATCGGCAGTTCGCGCAACGTACGACACCAGGCCGACCTCGCGCTGTTGCAGCTGCTCATGCGGGCCCGCCCCGCTGCCGAGAGCGAGCCGGTGCCGCCGTCCGATTTCGACACGGTGATCGAACCGGCCCAGCCGAACGGACATGCACCGACCACGGCCGGTGGCGTGTTCATCGAAAACTACGTGCACAACAGCCCTCGGTTCGCGGCGTCCTGGAAACATGCCCGCACCGTCGACATGTGCGGCTTCGGCCACAACCGGATGGCTGTCACCTACTCCGACGAGATCGGCCGCATCCTCAGGTCGGGCGGCCAGGTCCGCGTCCTCATGCAGGATCCGGAGGGCCAAGCGGTCCTTGACGCAAACCGCCGCAGCTCCACGCCCAAGGCATCGGCCGAAGACGTCCGCCATCAACACCGCAGCGCCATCGCCACCCTGACATCGATCAGAGCAGCGGCAGCGGCCCCGGCCGACAGCCTGCAGCTGCGCGCCTACGACATCATGCCGCCCTTCACGGCGTACTTCTTCGACGCGGACGACGAGCGGGCGCACGTCTACATCTGGTTCTGGTCGTGGCGACAGCCATCGTCCTGGCGTCCGGGCTTCCTCGTGGCACGGGCGACCGACGCGTTGTGGTACGCACGCTTTCGAAGCCAATTCGAAGGGATGTGGACGAACGAGGAAACCCGCGAGATCGCTAACGGGAGGGGATCATGACAGACCTGGCCCGCTTCTTCGAAGCGACCGGCTACGCGAAACTCCCTGATCGTCTGCCTCCCGATCTGGTGAGCCGCATGCGCACGGTGATCGATGATCATTTCGCTCGCGGCGTCCCGCCCTACCGTGTCAACGACACAGGAACGCCCTGCCGACTCGATGATCTGCTGGAAAGAGACCCTGTCTTCCTGGAAGCGCTGCGCCACGAGTGCGTTGCAGCGGCGTTGCGGCAAGTCCTCGGGCCAGCTGTCGACGTGGTGCACGCCAGGCACAATCATGCAACGCTGAACGGCCCAGGTGACATTCCGTTCCGGCTGCACCGCGACATTCAGCAGTGGTCACAGCCACTCGTCGCCGTCTTCTTCTACCTCGAGCCGGCCACCATCGCCAACGGCTGCACCACGGTCGTTCCGGCATCCCACCGTCTGCCGTATGCCGGCCCCCAGTCCGGCGGCGGCGGGGGCAACTGGGCCGACGAACACGACCAGTACCAGCACTTGATCGGCCAGGAGCTGCCGGTCGAAATGCCCGCCGGTGGCATCCTGCTCCTCAACTGCCTGTGTTTCCACAGCGTGGGGCGCAACACCTCGGCATTCTCGCGGCGCAGTGTGGTCTTCGCCTGCCGTGGCTCCGACGAACTCAGCCAGGTCGACCACCCCGGGGCGACCCAGCTGTTCGGCAAGCGCCGCTTCCTCGCCAACCGCGTACTCCGCGTCTCCGGATCACTGCGGCAGGGACAGAGCTGACCTGATGCTGGCTCTGTTCGACTTCGATGACACGCTGGTCAGCCGCTCTGCCGCCATCCGGCGCTGGGCGCGGTTGCTCGCCCGCCGCGAAGGCATGCCCGAAGGCGCCGTTGAGGCCATCGTCGACGCCGACCAAAAGGGCACCAGGCCGCGGGACGAGTTCCTGGCAGTGGTGCGCACTCTCCCCGGGGTCCACATGACCGATGGTGAGATGCGCGAGTGGTACGCGGTCAGCTACCCCTCGTGCTACGGAACAGAACAGGAGTCGATTCAGGCCCTGACCCTGCTACGCGATGCCGGCTGGAAGATCGGCGTGGTGACCAACGGATCGAACACGAGGACGAGCCAGAAACTCGCCCGCTCGGGGCTGACGCCGTTGATCGACGCGCTGTGCGTGGCGGAGGACGTCGGCGTAGGCAAGCCGGATCGAAGGATCTTCGAAGAGGCGGCCCGCCGCTGCGGTGTTGAACTGGCCGGGTGGATGGTCGGTGATGCACCGGTTGAGGACATCTTCGGGGGAGCACAGGCCGGTCTGCGGACAGCATGGCTCCGCAGAGGCCGGAGTTGGAACGGCACGATGACTCACCCCGACATCGAGGTCGATTCCGCCCTCGAAGCCGCGATCACCATCGTGAACAGTCCTCAACGCATGGTCAGCGGTTAAAGCGTGGTGCAAAAGCCGTGACCGGGTAGGTGTGGGCTGAGCAGGGCCTGCACGTGCCGGACGCGGCCAGCGAGCCTGCCACGCCACGGTCACCGTTACAGGTCGCTCACATACCTGCTCACGGCGGTTCCAGGTCGCGGAGTGCTTGTAGTTCAGCGTCCCGCCGTTCTGCACAGGTGACAGTGCAGTTCGCTTGTGAGTCGAACGCACTGTTGCTGCGAGCCATGGAAGCCTTGAAGGCTTCCAGGAAGCTCTGTTCGACCGTTGTCGCGCGCGTGTAGGCAGCGGAAAGGATGTAGGGACTGCTGCAGGGTTGGGTGACCCTGATCTGGCTCGCTGAGGGGCGGGCTGGAAGGATGTCGCAATGCCCAAGCCGTATCCGAAGGAGTTCCGCGAGGACGTCGTGCGGGTCGCGCGCAACCGCGAGCCCGGCGTCACCCTGGAGCAAGTCGCCGCTGATTTCGGCGTCCACCCGGCCTCATTGACGAAGTGGATCCGACGCGCGGCGGCTGAGGAACGCGGCGAGCCGGGCCCGGCCGCCGGTCCTGGCTCCGCAAGGAGTGAGTTGGCTGAGCTGGCCGAGGCCCGCAAGCGGATCAGGCTGCTGGAGCAGGAGAACGAGGTACTGCGCCGGGCCGCGGCGTATCTGTCGCAGGCGAATCTGCCGGCAAAATGATGTACCCGCTCGTCCGCGAGCTGGCCGCCGCCGTCGCCCCTCGTCGTGTGCCGGTGGCGGTGACGTGCCGGGTGCTCGGGCTGGCCCGTCAGCCCTACTACCGGTGGCTGAGGTCCCCGGTCACCGACACCGAACTGACCGAGGCCTACCGGGCCAACGCCCTGTTCAACGCGCACCGCGACGACCCGGAGTTCGGCCACCGCTTCCTCGTCGACGAGGCCCGCGCCGCAGGCGAGGCGATGGCTGAGCGGACCGCCTGGCGGATCTGCCGGGACAACCGCTGGTGGAGCGTGTTCGGCAAGCGCAAGGGCCGCGGCAAGAACGCCAAGGCGGGGCCGCCGGTTCACAACGACCGGGTGCAGCGCGACTTCACCGCCCAGGCGCCGAACCGACTGTGGCTGACCGACATCACCGAGCACCCCACCGGCGAGGGCAAGCTGTATCTCTGTGCGGTCAAGGACGTGTTCTCGGGCCGCATCGTGGGCTACTCCATCGACGCAAGGATGAAGTCCCGCCTCGCGGTGACCGCGCTGGAGTCTGCCATCGCCCGCCGCGGCCAGGTCGCCGGATGCATCGTGCATTCGGATCGTGGATCGCAGTTCCGTTCACGGAAATTCGTCGCCGTTCTCACCCACCACGGCATGGCCGGCTCGATGGGAAAGGTCGGGGCAGCCGGCGACAACGCGGCGATGGAGAGCTTCTTCGCGCTGCTGCAGAAGAACGTCCTGGATCGCCAAGTCTGGTCCATTCGACAGGAGTTGCGGATCGCGATCGTGACCTGGATCGAGCGCAATTACCACCGCCGTCGACGCCAAAGACGCCTGGCCCGTTTGACCCCCATCGAGTACGAGACCATCATGACCCCACCCGCAGCCCTGGCTGCATA

Protein sequences of DBSCAN-SWA_2

>CP034463|10251453:10310934|10284982_10285840_+|AZP22918.1|DBSCAN-SWA
MATPIYGPTESAEEVYQAAQAAFARDLKDLQLACDITYRQIGDRSPIVLSPSGIAETLRGKRLPSRDFLNALVRVLYEVQDEKPVSREDPRLRRWEERRTRVLLLRDRARQSNPGVGDPDTGPGDSFPTDTGYVPPPDGATLLELESAKSDLRDILNNLQEHEQRVRTEFRQVLDEQARVAAELSRLTSLLEQERGDKERLEREVASLKRQRAVLSEQLDDLRAQFAEIDADKVALLKEESDLNDRRAVLNFDWARYEELLRQRANAEVMRLREQLQRTLSDPPA
>CP034463|10251453:10310934|10255647_10257834_+|AZP22898.1|integrase|DBSCAN-SWA
MNASSPLPAGPEVVDPAPDAFVLPFNRLRPGFDPGQLPRFRDLAWRLALISPRESNRSLVIDWSRCPAGLRPGIMRAAFAELNIPTPAVLLQQRASRSTTQPGTLRHNFQIWIRFATWLGGRGITELSRVTAGDLEAYAEHLRPLGRQWRTDAKALGVISRLWAYAPYLPEHDRLVMPPWEDPAAVMSDFLGANDDTPGGENAVAIVHPAVMAPLLVWALRMVLDLSPDILAAAREHRRLLAAIPDRAPRGGTETAVAHLRGLLAAGQQLPSSGAPGATAVRARFGGPLPPMANTFLAGTLGVTTSQVARARGLLTDELTPTDFGPAPLLDVPLTARIGAAPWRAAIGFDDVDVLMLHLSTAALICCAYLSGMRPEEVLALRRGCCTRVERDDGTVRFEIRGRHFKGVLDEDGNTIGEGEVRADPWIVLEPVARAIAVVEELEDGEQLFTRTLYRYAKGTCMPRTGLSPDTAVERIRAFTAWANQLAAAHDRPHELIPPDPDGAVALRRFRRTIAWFVYRQPGGRIALAVQYGHAATAMSESYAGRSKADMLEVLDQEKGLALAETLTEAGERLAAGEKVSGPAADRYRAAATEFSDRYAGTYLGRRELRALVANPRLQVYEDPKAFLTCNHDAFTALCNPDRDRARNGGRSTPDHSRCHPACANISRTDSQITALRTEVARIDADADAGLNPYPIAAREQQRKDHLTAIISRHDAQQPADSEPTERR
>CP034463|10251453:10310934|10270480_10271227_-|AZP23776.1|DBSCAN-SWA
MLDKAAAVLDCFRPDGGMFRLTEIAARTRLAKTTAFRLCAHLVRLGLLERDGENYRLGGKLFELGSLVPRRLDLREAALPFLQDLFEATRETVHLGIREGHDVVYVERIHGHQALALPSRIGGRLPLTCTGVGKALLAFSGSELADEVLAGPLPRLTPHSVTDPARLRTAMEQIRVSGLAYEEQEAALGVSCIASPVFAGPTAVAALSVAVPRGRFHPAQLAPAVRTAALGLSRVLRSGSGTVGGTSS
>CP034463|10251453:10310934|10287349_10288477_-|AZP22920.1|DBSCAN-SWA
MHQLIVSPFLDGYLAVRPGRATCVRLPAERYEDIQHRAQTDDHVPDWLATTATEAWGLDLNGQTAGSALLVREPTEFGFARASWEINLYCNFGCKHCYLGERPLAGLSWEDKVKLIDIFRDAGVLWLQITGGEPTVDPDFEGAYRYAYRQGMMLTVSTNASRLWKPKLLRLFRDCPPYRIVVSMYGATKESFDELTQRRGAWKNFHKGMVAARNAGLSLRVSVVVTEDNAHEVDAMVALVQSWGLDHHVYTNMQPTFSGTGEPLLVQSTEHLRKRPVFQGCNAGVTFFHADPHAKVSICKIGRDDQIDLMAEGVDGLRRLGAISDRLMLRTGGCSGCSLSGSCRVCRPLAKVYQEAKAPLNAYCQHADTKEMVHA
>CP034463|10251453:10310934|10300770_10301100_-|AZP22929.1|DBSCAN-SWA
MNVSTQPVWAEERYERNKVRQLLVPGGTLQATDEAGALQVSNVYGSWPAVRTPAEAADGLTAVLPGSSGQEVHWQGSRMAHPPQAVVESYRDAIGFGCGSFEVTVGIKR
>CP034463|10251453:10310934|10271437_10272232_+|AZP23777.1|DBSCAN-SWA
MTQAAAVLEEAARTGAPCAPVRSLLPEADIDAAYAVQRLHVERGVAAGRRLVGRKIGLTSPAVQRQLGVDQPDFGALFADMAVSEGQPIAPGRLLQPKVEAEVALVVGTDLPHRDPTLADLLRATAFALPALEIVDSRIADWDITIVDTVADNASCGLYVLGGSPVPLDRVDLRAVTMTLTKNGETVSKGTGADCLGSPLTAALWLASTLARLGDPLRAGDIVLTGALGPMAVAAQGDEFTAHIEGLGTVTAMFASAATEGAAA
>CP034463|10251453:10310934|10284581_10284785_-|AZP22917.1|DBSCAN-SWA
MDQNEPTEPAPARDRLLDLAALTGLTGLSLLVYALGGATALSTISVTGMGLFTTWKFRERPPHDRER
>CP034463|10251453:10310934|10275938_10276574_+|AZP22912.1|DBSCAN-SWA
MSVDVLLRLHDVRKAYGRRPVLRGVSLDVPRGCLLGIVGANGAGKSTLLRILAGQAVGDSGTVQCRGRIGYCPQNTALHPAFTVAEHVRSFQAAYRLESCARAWELLEELGFDESPRSRMHTLSGGTRQKLNLALGLMHDPEVLLLDERYQGFDWETYLRFWDIAQGLRQRGRAVVVVSHLAYDRDRLDVLYQLQDGVLAAEHSSAAGSVA
>CP034463|10251453:10310934|10289850_10290375_+|AZP22924.1|DBSCAN-SWA
MDLITPAQRDELFNDFERDAFHLELRDDYGSPIEDTPYARWQRGEPDDYTWLDPWMTLMKRVTGQGKRVRRVRVVTEPHSQYVGWEHSLTHLNIEAGEDIRWFPRHQLPEGTFFPLGGNDWWLYDDQLLAVGHFDPEGRVLGSEIIEDPDTVAECVRVRDLLWADAIPHTEYKP
>CP034463|10251453:10310934|10251453_10252262_-|AZP22894.1|transposase|DBSCAN-SWA
MPADLVPDDLWERIAPLLPARPARRHRHPGRLPVSDRVALGGIVYVLRKGVAWRDVPIQVVGCSGVTAWRRLRDWTEAGVWPRLHGVLLAELRAVGLLEMDDSAIDGSHVRALKGGPHTGPSPVDRGRPGSKHHLIVDRHGTPLAVTLTGGNRHDVTQLLPLLDAVPPIRGLPGRPRTRPRRLFADRGYDFDKYRRLLWKRGIKPLIARRGVAHGSGLGKTRWVVERTFAWLHQFKRLRIRYEIRADLHHGLLQLACSIICLRRLRTLF
>CP034463|10251453:10310934|10267177_10268968_+|AZP22906.1|DBSCAN-SWA
MVVRPHAPPPRRSTRRLDATSCRTRAPIASSAGLGSSHVPMAVLIAGETEMTELSLAVGFTSVSGGSDERAMVLTAFMAFIVLSLLLCILAGPEGDTTADFYTGNRSLTPVQNALALTGDYISAATLLGVSGLVAVAGYDGISLAVSSCLAVGVFLLLAGPLRNAGRYTLGDILALRSPGSSSRIAAATATLAVCVPFLVLQLAGAGSATALLLGLTSLGAEQVCTAFVGVLMIGYTVLGGMRGTSLVQIVKVAVVFTTMVLLALLVLRHHDFDLGALLTAAEQGSGLHGRYFEPGQALSDGAAGRLDFLSLQLSVVLGGACMPHVLMRINSATDSATARRATRYAIAIMTAFFLCVVIAGLGAAGVVGGQKIRALDSSGQMALLLLAGELEAGTSGLAGNVLYTAVACSVFVTVLAVVAGIALSAAAALAHDLHAHAARRGRMSERREVRSARWAVGAVGGLCIFVAVMAQGRNFQSLTHLALTLAASTVLPACLYGLFWSKYNRTGLLWTVYGGVLCTTALYVCSLSFSGTPTSLLPGQDFHLVGLQSTAVMAIPAGFLLGWMGSAAGQRAQPMEGAGTDLRWRERVLVGAREE
>CP034463|10251453:10310934|10306921_10307962_+|AZP22934.1|DBSCAN-SWA
MRVTVATLARAQGLRDDFDSLQRLRHGRGIASPGDLYYLSEFVKRRVLCIEDDTDSQLTQGLDNLKKLIERAPPRERELLRLSFNIDGAFGDFNWLERVEDFALAHEWIGSSRNVRHQADLALLQLLMRARPAAESEPVPPSDFDTVIEPAQPNGHAPTTAGGVFIENYVHNSPRFAASWKHARTVDMCGFGHNRMAVTYSDEIGRILRSGGQVRVLMQDPEGQAVLDANRRSSTPKASAEDVRHQHRSAIATLTSIRAAAAAPADSLQLRAYDIMPPFTAYFFDADDERAHVYIWFWSWRQPSSWRPGFLVARATDALWYARFRSQFEGMWTNEETREIANGRGS
>CP034463|10251453:10310934|10307958_10308708_+|AZP22935.1|DBSCAN-SWA
MTDLARFFEATGYAKLPDRLPPDLVSRMRTVIDDHFARGVPPYRVNDTGTPCRLDDLLERDPVFLEALRHECVAAALRQVLGPAVDVVHARHNHATLNGPGDIPFRLHRDIQQWSQPLVAVFFYLEPATIANGCTTVVPASHRLPYAGPQSGGGGGNWADEHDQYQHLIGQELPVEMPAGGILLLNCLCFHSVGRNTSAFSRRSVVFACRGSDELSQVDHPGATQLFGKRRFLANRVLRVSGSLRQGQS
>CP034463|10251453:10310934|10298645_10299173_+|AZP22927.1|DBSCAN-SWA
MVSLPEELQAREAAARRRVEALQAEAAELAIRLEAAREDLSRLEITRETVAQVLAELSAAQAGPHLAAGDAPAPDETSVPHGVGVMMVPPWREGLVVAVLPDVYRDIVEIIADAPGPLQAKQIVPRIGLPTTTGKIEGTREKLKRLVERGWLDENTPGQFTLARQGPGRDRSNSQ
>CP034463|10251453:10310934|10293497_10295804_-|AZP22926.1|DBSCAN-SWA
MTLVCSGGDWRADVLRMVECYARTWGGDGHGLIACSPEWEVAEPFWRLAEAFDADHWAVFARTGRGLQMSDPRAYEAQLASYVEGWSRENDVDEAQARRMLEPQLLSSGAGMVAPRELGDRIRRRMAPLASAQVTVTAEFRADEAPPHRLVDMCGLTFQPARITGFDADELPPAVQLLVAARAGLVAPGHLARLRERGEVDHATVPVHREDLAQVLRYAWTGRPETGADFTQQDFLDDLPLAQSRLGCSWFTTFDTDADSEPLVVICGDSAEDFCYAYTRQRVVGDAHWLPVGPDTEDLSPQLHTELMQILYDLAVPLVSARPLLLSSLTLGEDQMHAVRDQLVATPWGRMAASGSPGRLDVQVCAPADLPVCRRLHLLDKAHVGDTLHEPFLGTDQARNVEIPLPSEAAGVQPDSCRWQVDVLDPKAVLPARWALNDVITADGTSWGVRSSTSGISIDSHGRIFTVTGTSLAQLLVQVRLRLPTARQVFSTLLAGAGITLEESDKGRYTRRMIELWGDFAALAADLKEGPAANLLSGWISAGKELGRVYQDRKYLTFADVCSITGGSEEGARQLLDGYLQRSIATRGLLLTCGQCVGTAFYRLEDIGAHFRCQRCRQHNPIVRSAWKGQELEPQWYYGLDEVAYQGLRSNVQVPVLALAALSEPARSFQYMPEAVVRRDGYPDLEVDLWAIVDGRIVIGEAKISDRLEQTKREEARRCAALKGLIDELSADEFVMATTGSAWDRRTETLVNEKIAPTAKVTWLTNLR
>CP034463|10251453:10310934|10269055_10270216_-|AZP22907.1|DBSCAN-SWA
MSATERADSRGMRRRGLLKAALPLGATATVLGTGSASATGSAFSDAPARRGRDRIDVHCHLIPDFYRRSLAAHGITNIGGVPIPAWSPTLAVDFMNRYGIQTQVVSVSEPGVTYLSSSEERVAMAQRLNTYTSRDLVHTASARLKGRFGGFAVLPLSGTADEQDVSHAVTEARRAVRDLELDGVGIFSSYGGKYLGDPVFEPLMKALDDLGAMVFIHPVTPQGYPDLGLPPFLYEFTFDTTRALVNMLYKGIYQRYPRIRWLAAHAGGTLPYISYRTSLLTLTPAIAQQVGAAGLDDSSPYFRKLFYDTALSPAPQAMKSVRELAGPEHILFATDWPFTSALFPAAGDPAPQLDRTFSFAERLAVERSNALAQFPALAARIGARPA
>CP034463|10251453:10310934|10265561_10266581_+|AZP22905.1|DBSCAN-SWA
MNTAATSTASVFGAVHLGYIIIETNRFADWRRFGTDAIGMHHDTLSRDLMRFRLDDQECRFLLRRGPAEDVVATGWHIDDHATFEQIEARIRAYGVPLVQGSDEEAALRGVERVLRFPGPKGITQEIYTTPVKSAEPLRMLASGFVTGDSGMGHIALTSTKPTQIRGYFNTVFDARLTDYIDETISGVKLKIRFLRVNERHHSIAVAATRGLPIDPIRTRVQHLNIQAATLDDVAQSYQRVHELGFDMALSVGQHTNDKELSYYARTPSGFEWEVGWNPIVIDETTWEPTTHQGISIWGHLPVGQTIVDKLAQFRAGARSLTYPENTVPALSGAGIADD
>CP034463|10251453:10310934|10291246_10291429_+|AZP22925.1|DBSCAN-SWA
MQPVAPNWRTSTYTGTENCVEVADNDPTMVMVRDTKAPSGGLLAVQPTTWVAFVEFAKAK
>CP034463|10251453:10310934|10260210_10261260_-|AZP22900.1|DBSCAN-SWA
MSPSAHRIDVHQHVVPAFYRDELATAGIADAGGRALPDWRPESALRLMDLLGITTSIVSVSTPGTGFLTDPAKAADLARRLNDHSAALASDHAGRFGFFATLPMPDADASAAEAVRALHDLRADGVTLLANNRGTYLGEDDQDALWQTLNDRGAVVFVHPAQLPVPPVDGIPAFAADFLLDTTRAAYLLVRNGIPRRYPDIRFILSHAGGFVPYSSHRMALTIANDTARSPLDVLDDFRSFYFDTALSSSPAALPTLLAFARPGHVLFGSDWPFAPTPAGQYFANGLDDNVAPDTLKAVNRTNAEALFPRLAATSPTPPPALPAPVRLRQAAQRTAARLVFKLLQPSTD
>CP034463|10251453:10310934|10283505_10284453_-|AZP22916.1|transposase|DBSCAN-SWA
MSKTTPLDREAKRRLAVIRHVEEVTGNVAMSCRYFGISRQAYYIWYRRYQAEGIEGLRTRSKAPKHSPNATHVEVVGKIIYLRQNYHFGPEKIAMYLKRYHDVTISKSGVWRILNRLDMGRLPASQRYKRHDRRWKRYEKKLPGHRVQIDVKFIEPLASMPQGRRGGRNKYFQFTAIDDCTRLRVLRIYPTLNQATAIQFLDYVIQRLPFQVEVIQTDNGAEFQSAFHWHVLDKGIAHTYIKPRTPRLNGKVERSHRIDAEEFYRLLEGVIIDDAEVFNDKLREWEDYYNYHRPHGGLGGQTPYERLKQKTTTQA
>CP034463|10251453:10310934|10281774_10283124_+|AZP22915.1|DBSCAN-SWA
MTGFVRGGRLPLWETTVVPEDFRPVDRRPLAMVLAANLLSVTGNCLTYMGVPWFVLQSTGSAAKAGIVAFCTLLPAVLAALVTGPVIDRMGRRRVSVVSDLACGAAVAAIPLLQFAGILQFWMLCVLMAMTGLFRAPGETARGVLLPTLAERAGMPLTRAAGLYDGAARCAALTGSALGGVLIAVLGAENVLWMDAATFAVSAPLFAFGVRGLPAAQAQRQVEATSLRAYRRELAEGYRFLAATPLLLGLCLMTLVTRGLDQGWSAVLLPVDARGQLDGAVDLGLLNAAFGVCALVGALVFGAVGSRFRRWPVFTIAFLIGGLPRFVVAAFTDTFAPLAVIMAVEGLAFGVLSPIMATVTYEAVPEELRSRVLSATTASVQLITPMGGLAAGFLVDSAGLPCTLLSVGGVYLLATLCPLIFPVWRQLDSTGSAHDRAASSPRVSGSKQV
>CP034463|10251453:10310934|10280464_10280740_-|AZP22914.1|DBSCAN-SWA
MASRLFDPALLALGVLASRSTTRVTASTSDLTPIVQSLRAVSEYCVFSNVASPAKCAGWPVRVTQDHPVRACSSGLVGGEGVVPKRRSRRV
>CP034463|10251453:10310934|10288919_10289288_-|AZP22922.1|DBSCAN-SWA
MASVSEEPKAGIDSLPVDVELLSDTTDDVLKMELSTSTREDIDFKTTRVVGLLSLLLAEDRGADDDDEGMDLFRQAYKLLELTNRPGRQTPSFTAFFYMRDVANLTRRLMWVYTERNGGVPR
>CP034463|10251453:10310934|10288731_10288923_-|AZP22921.1|DBSCAN-SWA
MTDTRLPGVGDEVEYQPGCRAIVTDVSHGVPILRAAARAEWPADKPDQLVVTRTRQERIEAGA
>CP034463|10251453:10310934|10261507_10262299_-|AZP22901.1|DBSCAN-SWA
MTPAAARRRVEAAQLLREAERRTAPIEPLSTTWPDLDLADAYAVQQDNIARRLAAKATVIGHKVGLTSAPVRQLLGVHEPDFGHLLDDMVHRDGGTVRAARYCAPRVEPEICFRLARPLRGPGVTTADVLAATGAIAPALEIVDSRIRDWRITLVDTVADNASSAGLVCGSWTPMDYTPDLAAVSVDLLVDGSQVAFGSGKEVLGHPATAVAWLANALADFGMELDAGHVILPGAMTTAPFIGTGQKAEARFGALGSVSVSFI
>CP034463|10251453:10310934|10302974_10305344_-|AZP22931.1|DBSCAN-SWA
MAGRREKELVARVPEMAEVARWLRQSRHLSGLTYEDLVQATGFSRGRLNRAAHGWRSPWPVVEAFTRACGTDVAEARQLWLKAKAALEGIDQGPDVISIGQVGTFEELREAMNRLRALAGSPSLRELEDRAGKRLTRSTLSNVLSGAVNPRRNLVVMFAEIVGVGRSEAAAWAAAWERADTNSRAARARTARDLKAPAKPLMLVPAPAALAALADIPLAEWAAVAELVDAVMKGSTGAGQHPAVTVGFQHDPDSPGHETITVSCRHTGMDRDTISKAFLASWTGGTQDQDIFGLGFVVACLQLGAHITLRTARAGDTAWTVLTFDLASLTAGSPWHALIGAEPKAAAEDQGTFITIKALRDPWPPGRQNRLRHQLGDIYSYLLRKEQVQLTVSDRPVAPRMPCIWGENRVVQRREGNIAAVQRLDIVLATRYRCRNCRHTSPLGSPHCLQCQGTQLELTEQRVWGWLGVQRYLHGSDYGLDFYRNGRKVLVRDKGLFFFEDGPDRSMVEYPVDGPAKGRLVGEIHCDHVPVNFTKTAFDYDSPEWRAVVHAVRGPGPLAPRHAQRLGYAPNTSPLATLFRAFRRNDPGLRNLIPGDGAKALHDEAAAWAERFRKGDPAYQSDDKWYEAALAHDTPRPAVVAAADDRIDLVSLSPEDLDDLVHRLCMELHGTTEGGPRELIGPGPATTVLRDRPTTGERWVLQCRRNRHVVPLETVHALAGQMLDVQASRGILVTTSWFGASSHAFAQRSGRIDLVDGRTLKALLREHLGIEARLGLGRLPPEWNPGDIA
>CP034463|10251453:10310934|10306491_10306779_-|AZP22933.1|DBSCAN-SWA
MLPAPRGHRLARIPEPQPIVVTTTPCIPASGRPCGCGAPHCCEGGAAGRTRGRPQRASRMPRRLLHEALWAAVAGAAYTCGATGTGTVLYWFIHR
>CP034463|10251453:10310934|10258638_10260198_-|AZP22899.1|DBSCAN-SWA
MSTSPHRKSDDQTEDRQDAVATGRAGHNGVLFAMCLSLVLVVASVSALNLALPDLAIDLSATNGALTWIADGYTVALAALVLPLGAIGDRIGRRDVLIAGTIVFGAASLAASFADSTTTLIVWRVVMGLGAAMIMPGTLSTITAAFPPEQRVKGVATWSGFAAAGAIIGMLAAGALLEWFSWRSIFITSAAVALVAAVTALLLSPNTKDEHPSPPDVSGAISTAVGIGALVFAIIEGNEQGWTEHIVIAALVVTVVAFAAYAWLGLRHEHPLLDPALFGIRGFRAGAITVLVQFMAVFGFFFVGLQYLQLILGYSPLKAAAALVPVAVVVLPTSQATPHLVRRVGMKVTMTVGLLLLSAGLFVISQLDVGSGYLPFLGGLILAGFGIGLSGAVGTSAITGSLGRGQQGVASAMNDTTREVGSAVGIALMGSIYGSHYRSNLPDSVDQLPAEASEAARDSAAAGLHVADQLGARGAALADGVKSAFMDGLSASLIAVGIIVLAAAIGCLLRAPKTPPTSD
>CP034463|10251453:10310934|10290427_10291237_+|AZP23779.1|DBSCAN-SWA
MRGFRKDAGFASGRAFALATGWAESKVSRLENGRQNPSEDDIRVWCTKTSRPEHIPDLIATVRHIDELWLEWRRQLQTGAEQRQKKALPVYAKTKVFRIWHPTLVWGTLQTVEYAAETFRQVVDYYEIPDDAEAATAKRLERQQYLYRGNRIFNVVLGEQALYTNFGGPEVMKGQLDRLLAVMRLPRLSLGIIPRSAPVGIWPGNSFSMFDDKLVLVETYSAEFSVTQPREIELYAKAFALLKQSAVYGTAVRDLILTASQHFDQMPSD
>CP034463|10251453:10310934|10297090_10297675_+|AZP23780.1|DBSCAN-SWA
MQALADDLVEDYVEHCRMHGSSWTDIGAALGVTRQAVQQRFHAPHKRYSPETMTDDLRQAMVHVKQAAVQHRNNYIGTEHLLWGLTAEDNSATQLLQTAGVSSKTIHRSVGTRLSMGASQAAERIAWTPYARKAIAIAEARSEQNGSDRIDCDDLLIGLAQVGRGVAANVLTEAGFHPAALNATTADTHSSQNG
>CP034463|10251453:10310934|10274613_10275399_+|AZP22911.1|DBSCAN-SWA
MNPYHHDGSLGHWPEPGDDLASAHPPRRRMRRRAVIAATFLVTVGATAIIVDRVAASRAESRTAEAFQQGMGTPERPSVDIRGFPVLPQLASGTLRHVDITAQDIPARGTSRPLPVTRLSVGLDELQTSGEADEAHAQTVDATAFLSYEDVSDALGLEIAGDSEPNRVRAQLVLPFSGEVTVSTAIAAVGANRIAFTDVSVIDGHLPAAGQALLDKVLAEPIQMRNIPDGLHLRSVTATPSGLNTHLTGDQVTFRPGTSSA
>CP034463|10251453:10310934|10276624_10277731_+|AZP23778.1|DBSCAN-SWA
MSALLRPARCVGSGAGRLDLDRIVRSIEEALTVFVADKVSGSRAEEPGLEALLDAVGDFISAPGKRIRPLMCVLGWYAAGGTSPVPPVSVLRVAACLELFHAFALMHDDVMDGSDHRRGRPSLHRTLAAHHPGRPGADRLGANAAILAGDLVLVWSDELLTSTPMTPEQIKAVLPAVYRMRREIVTGQYLDLVTTGRPTDSLSTALRIARYKTAQYTVEGPLHIGAALAGADQALLHVLSTIALPLGEAFQLRDDLLGTFGDPRRTGKPTLDDLREGKHTALLACALRRADRAGQELLLRTVGAADLDAHTAARIQGLLEECGARQAVEDLIQERHHQALERLNHAHLPPAAAFALRDLIQAVHNRTA
>CP034463|10251453:10310934|10272228_10273179_+|AZP22909.1|DBSCAN-SWA
MSTKVAVIGSGNIGTDLMIKVLRLSDSLEIAAMAGIDPNSDGLARARRLKVATTHGGVDGLVELDEFADVEIVFDATSAGAHRRHDEVLRSRGRRVVDLTPAALGPYVVPPVNGDDHLDAPNVNMVTCGGQATIPIVAAVAAVTPVHYGEIVASISSRSAGPGTRANIDEFTETTSSAIEKVGGAARGKAIIVLNPAEPPLIMRDTVYCIIGECDDTAVTASVQDMVARVQAYVPGYRLKQKVQFERLADDDPLRSLLPAGTRSADAAKVSVFLEVEGAAHYLPAYAGNLDIMTSAALRTAERMATAQPFTEVVCR
>CP034463|10251453:10310934|10308712_10309372_+|AZP22936.1|DBSCAN-SWA
MLALFDFDDTLVSRSAAIRRWARLLARREGMPEGAVEAIVDADQKGTRPRDEFLAVVRTLPGVHMTDGEMREWYAVSYPSCYGTEQESIQALTLLRDAGWKIGVVTNGSNTRTSQKLARSGLTPLIDALCVAEDVGVGKPDRRIFEEAARRCGVELAGWMVGDAPVEDIFGGAQAGLRTAWLRRGRSWNGTMTHPDIEVDSALEAAITIVNSPQRMVSG
>CP034463|10251453:10310934|10277912_10280543_+|AZP22913.1|DBSCAN-SWA
MRWWGRCLGTAVRHAALEQARKRLALVLVLFFVPLWLTLAYQVLPSDPVRFFLRAADQRVALGANTVSQLSGGLHSLALIVGFMMFLAASRSAEFDHRMVLAGYPRICLLLARSTVLLLTAALTASYATAWVCFFYRPERLDVMAAAFMVGALTYGGVGILLAALLRSELAGMFAVIMLSFIDLTLQNPVANPSADSPLLKWLPAYGAMQSSVSAVDLTHTPWRHLLLGLCWSAGLTAAGLAAFTARTSRRTITQRLLGGRATRPRARQIALRLLHPVRTYVYRQAGIHDTTVITGYEICRRLMHRSGPVEAALTKLLPGRLRPLFWAMYGYGRHIDDLSDTQHLDRQERVERVSRFSELLEADLRAGHSEDPLRAAFVHAVWTWDLPSDGVTALNAVYRQDAKGQSAITTWDDWYTYWRTLTFPFGVRRLMALLTTPGLAFTPDDAQALRVWTDALNLIDVLRDLREDAAEGFVKLPAAVLDEHDVSPEALAHGRADGRYADMVHAMTAKARQWLAQAATAGAQHPPMAAALQTVIDLHLLELDRIDRKPHALLQRRSRANPVRFHLTLARGRLRTARAWHRHTQTTATTPATIHLPHPAEGHHDTARTTPPLPPVPHPSGVQPPQLPAHLVPRHVALIMDGNGRWATHRGQPRTAGHKAGQLAVRDVIYGALEIGLPHLSLYSLSSENWARPAAEIQAILRLVRDGLVMETEEVWRRDVQLRWSGLPEGLPPDLVHALRETEHLTRHRTGLTVNMCINYGGHSEITQAARELARQVAAGTIQPDDITPRHLAAHLHHPDLPDVDLLIRTGGEQRTSNFLPWQSTYAELVFLDTLWPDTDRTHLWQAIDTYTRRDRRFGTTPSPPTNPDEQALTG
>CP034463|10251453:10310934|10263068_10264676_+|AZP22903.1|DBSCAN-SWA
MSETGAGTETEDSAYDVAVIGYGPTGVTAANLLGAMGLRVVVLERDAEIFTRARAISTDEEVVRIWQRIGLAERLKQDMLTEREVDFVDANGRTFLSAHPTPRGHGHPPQMFIYQPALEQVLRDGVGRYPNVKILLRHECLRLRQDADGVELTVVGTADDSVHRLRASYVIAADGGSSLTRAQLNIGYEGKTYEDRWVVIDTKMLKPWPDHDKLRFHCDPARPAVDCPTPLGHHRWEFPILPGDDEKQLTTEEAVYQLVARYGISRDSIEVLRATVYSHHVRFATRFRMGRVFLAGDAAHAMPPWIGQGMAAGVRDVANLCWKLDAVLRGELPETVLDSYEAERKPHVKEVTKRAVFVGGIITERRLPVARVRNGALRALDRIPGFGDWMQDSNWIPVARYEAGLQARPRTKATGHQIPQPWVTGPDGTRVRLDDALGGRWILLHAGTAIPQPAWNLVGVPSLTITLTGSRPTEGTLVDNDGVLLPWMTRHGAATLALRPDAYVYAATPGGAPLPPPPRGFTPSTTPRPTASTAQ
>CP034463|10251453:10310934|10299242_10300781_+|AZP22928.1|transposase|DBSCAN-SWA
MEPYDALPEPDPYSASRDAFERLISTLADGPAADLSHDELEAQLEELGRELLRHLMQNHLDQRARKEEDTMRADRGQPLVLGPEGQPRTWREMGHRRLLTCVFGPVRVTRIAHRGRGVANVHPADEKLSLPAGRHSRGLARLAVLEAVRGSFDQAAAAIERRCGKVLGKRRLKELVVASAVDIAAYYTAKIPTPCTREMPLVIEIDGKGVVMRPEALREATRRAAAKSAAAGRRGRLAPGEKPNRKRMATVACVFDVVPAPRRPHDIVHPPGGRSETRPPRQGPKAERKWCTASVMHSPELVVADAFDQAEARDPRHLRDWLVLVDGARHQLDLIQAEADRRGIHLNILLDFVHVAEYTWTDAHAFHPVGSREAETWAADKLTAILAGHADRAATEMTAQAAAEQLPATRCDAVTTCARYLTGHLDQLHYDTALTAGWPIATGAVEGACRHLIADRLDITGARWGLDGAEAVLQLRALITNGDFEDYWRYHAVREHQRLYPSPDPQNYGLTA
>CP034463|10251453:10310934|10289471_10289879_+|AZP22923.1|DBSCAN-SWA
MKLRFLGKNSTPGDSPTLYASDQDSYVIQGWKVFANELLMQLNVPEGQAAIEVPTELFEHLTKDGQVSGEIRKFTAPIMLVTEQGTCVLQGPEVHDPEALSQMRMPDYETCIEVPKSSITALLEEDSGPDHPRAA
>CP034463|10251453:10310934|10309736_10310934_+|AZP22937.1|transposase|DBSCAN-SWA
MPKPYPKEFREDVVRVARNREPGVTLEQVAADFGVHPASLTKWIRRAAAEERGEPGPAAGPGSARSELAELAEARKRIRLLEQENEVLRRAAAYLSQANLPKMMYPLVRELAAAVAPRRVPVAVTCRVLGLARQPYYRWLRSPVTDTELTEAYRANALFNAHRDDPEFGHRFLVDEARAAGEAMAERTAWRICRDNRWWSVFGKRKGRGKNAKAGPPVHNDRVQRDFTAQAPNRLWLTDITEHPTGEGKLYLCAVKDVFSGRIVGYSIDARMKSRLAVTALESAIARRGQVAGCIVHSDRGSQFRSRKFVAVLTHHGMAGSMGKVGAAGDNAAMESFFALLQKNVLDRQVWSIRQELRIAIVTWIERNYHRRRRQRRLARLTPIEYETIMTPPAALAA
>CP034463|10251453:10310934|10298019_10298436_-|AZP23781.1|DBSCAN-SWA
MVSFAAWRDTAPHTGHHADRHYVTLAELLIRLGSYGLTLTWRARIFDDHPHSSFAELVRASAGHGIPTLELLAMDAPHLQAVDGDFEGYAGSELVLTLREFDSSSWDVRTADEWVLNEIRRHYPDAKPMTPDEWDATN
>CP034463|10251453:10310934|10262295_10262928_-|AZP22902.1|DBSCAN-SWA
MTKPQTTRKKRANGVESRQRILDAAVEIAGERGYEGTSIAAVSAACGLPASSIYWHFKDKDDLIAAVIERSFDTWLAAVELPGEETGTPLERVTAMAGNVAKSLIDAPDFLRLGLMLALERRPAEPRGRTVFLQVRDIACAKIAEMAEALVPGLDEESVQILTTYAVAGADGLFVQREINGDAVDLVAMLELHAQLVYEAATRMAARNKA
>CP034463|10251453:10310934|10264689_10265565_+|AZP22904.1|DBSCAN-SWA
MTTTPTGLPTMQETTYDIGGRKIFAAETGDGPPVLLLHGGGPGASGVSNYARNISELAKDYRVIVPDLPGYGRSTKGVDGSDPFGYLADGIRRLLDELGLKKAHLVGNSYGGACALRLALDTPDRVDRMVLMGPGGIGTTRALPTPGLNSLLNYYTGDGPSRSKLEKFIRNYLVFNAADVPDAAIDERYQASIDPEVIASPPLQRPSGPNALRTLWKMDFTRDARLSRLPVPTLVLWGAQDKVNRPSGGRMLAERMPNCDLYLVANTGHWVQFERAELFNRLCTDFLAGRR
>CP034463|10251453:10310934|10305359_10305581_-|AZP22932.1|DBSCAN-SWA
MSKALLCVGDGAPVPRHLSDVVMVVAVLIVVVGTLGSAAAWQDAAQVLVTETVAAVVAAMVVAVVKPSAHDRM
>CP034463|10251453:10310934|10273175_10274207_+|AZP22910.1|DBSCAN-SWA
MTANQPPALYVQDVTLRDGMHAVRHRYTVDQARTIAAALDDAGVAAIEIAHGDGLSGSSVTYGVGAHTDWEWIEAVCDSVHHAVPTTLLLPGIGTLHDLRQAHALGIRSVRVATHCTEADISAQHIAAARDLGMDVAGFLMMSHMADPAELARQAKLMESYGAGCVYVTDSGGRLTMDGVRDRVRAYRDVLEPDTGIGIHAHHNLGLGVANSVVAVESGVTRVDASLAGQGAGAGNCPLEAFIAVADLMGWEHGCDLFPLMDAADDIVRPLQDREVRVDRETLTLGYAGVYSSFLRHAEAAARQHGLDTRAILVEVGRRKMVGGQEDMITDIALDLAKAGSVG
>CP034463|10251453:10310934|10254310_10255651_+|AZP22897.1|DBSCAN-SWA
MSGRGRRAALPPTDYRKAPVLDADGLVIRPVSGAGKPLGVWDFRDSPGPVDFRRALVAALAAQGRGWGSQDTYQTNTSTLKLLFKHAAAAEPPVTATEHITVEWWKQWSGDIHVRRVLAAVVRRAPGVPEATRVFMETPRRRPPARRGRRRHASNTLVDVGEGSSGRALRHVLELTAQARTTLEALGRPATKLLVGHRGLGGAENLRDHEVGKALEGAIRLWQQQVRAGGVDLPARVHAQALRHSAQAHHGRARNNTQDTHERDYQLQDEDVRAASRGAVELGLAQALASARQTVAMRLVEEVDAVGEVSPEPVAQEAGIDVEVARRIVAGRLRTPVASCADFLNSDHSTAGMPCAVSFLLCFSCRNAVATGRDLPRIAYLHQALESLRSAVTPAVWAADWATHHARIGDFLTTYTTTDARPQLFAAVADSERELIHAMLERRLDP
>CP034463|10251453:10310934|10301204_10302638_-|AZP22930.1|DBSCAN-SWA
MTAVQATPSALPRDFFCEHSASKSRVLVLLAHPDGPSSLQAVMTCKDALVAQHAALLLSLAARNGILTAPQQNTAGKLLTVLPDAPAASFRQALDQARAGVWPAGSPGFTWPSDDPFDWVQESGTEEALPVSAIRTPRDARLADLPGPVIRVVQLREFHVYDQAKALTAAAASGWEPAPQEELTQEDPHDLTGAVMFAAETTGDLPGADCLNDTQEGQLLLSAQGDEVADWSAEPVRVDFGSGWRLHRTNRSGTASSTGAVPESDQEQPDFAALFALPAACDCEEEDCRKCDWTLTPRTAELLYSALVELAESAYDDAAELGDRPVIKDDDGAWGFFSRLPQVTWRQNAQWRRGLARACDDLAGDLASGRWPRPVCAAEEMVLHLALDDALEHLEAGDGSPHAALPTHRDDYDFDACSDFFFQDHDVLWLYDSKYSEDAGEAEGREPVGVPPALHPDNWFEDFLNVPARSPERGYRR
>CP034463|10251453:10310934|10271225_10271414_+|AZP22908.1|DBSCAN-SWA
MFPCALFRVMERILPLLEAYAYTCHGSTDGHRRLYANPAALSPEVTRMFAPHHRSTACRGRP
>CP034463|10251453:10310934|10252937_10254314_+|AZP22896.1|integrase|DBSCAN-SWA
MPTTCQRQGEQRAHVRRWRDPGDGTLQAAHAPKPSPVILKPSVSECLRRSAFSAKAQGTQVTYAPLYRLFFTFLWQRGLDWNEASEDDVEDWEDWRRRGATNPAPVDGGTWAKEQAALKLLYGIAAKRGLVPANPVTLASPTDVKTSDVKWLSPRAFRLWRNVGLGGMLPSGLEDEAWRGRSAGRDMAYADLMYSSGLRRREGGTLLLCELPALGRRNYYAGRVGQGVAKRAGYTFYVGHPALQRVEGYRMSTRALAVARARRHGVYDRLPDLRIIQSVSRAGRVRWRSRDGRAGESALGRLTAAERMLLFVEGEDGLEPAMLWLTESGLPLRYTSWTKVFERASDRCAAAGLEVFATPKMLRHSMALRTLIALHNALDRRLGLTPAERLHYEEVYGQVWLMVKDMLGHRSDQVTRDVYLEPVRGLQLESLLGDDHNPVNAEKIAELAARTGLILDAA
>CP034463|10251453:10310934|10252338_10252920_-|AZP22895.1|DBSCAN-SWA
MTSSDHLLGLIQTAPEVDLLLRSSFGFDIHRKHNGDGLRLASGAPLEVIAGESAGGAYFLCAEQNGRRPVVFASSEGQGGLLADDLADALEIIIGLEWRDCLTFSGGGDVEVMQTSAQHLERSRDKHNPDIDKEVTQVAAALSLRIVPVADLIIRLHAAASKTEPDYVVTDDDGQVFDPPFGERVEPRHGGWR
>CP034463|10251453:10310934|10286232_10287102_-|AZP22919.1|DBSCAN-SWA
MRFRWDWLRPVVLAPYVPTIGPVHPSVLTEDLFTDTLIAASTERWFLRYDKDIRWSDSKDETVLVQDIAHQPGDTLIPTLSRRGAGTIKVHLYGTEPGSALTATELAQKLAAEHGAASARIVRFLGPEAADGRGTRIHLQDFTTAICPAPDGPVRLLHEWPAGVQDTFAGFAQRMAADGFTFLHQQMQAKAVGPVLTAVAKGRVAGAIGPMEIRPDAIGTPQLMPQYFGVLTEHRGQGLGRLLWRAAMYWGQVNGAAYQLLQTEVAGASDRLCRSEGLTSLGFTYWQAA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZP22894.1|10251453_10252262_-|transposase	IS5 family transposase	NA	NA	NA	NA
AZP22895.1|10252338_10252920_-	hypothetical protein	NA	NA	NA	NA
AZP22896.1|10252937_10254314_+|integrase	integrase	NA	NA	NA	NA
10254036:10254050	attL	NA	NA	NA	NA
AZP22897.1|10254310_10255651_+	hypothetical protein	NA	NA	NA	NA
AZP22898.1|10255647_10257834_+|integrase	integrase	NA	NA	NA	NA
AZP22899.1|10258638_10260198_-	MFS transporter	NA	NA	NA	NA
AZP22900.1|10260210_10261260_-	amidohydrolase	NA	NA	NA	NA
AZP22901.1|10261507_10262299_-	2-keto-4-pentenoate hydratase	NA	NA	NA	NA
AZP22902.1|10262295_10262928_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AZP22903.1|10263068_10264676_+	bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase	NA	NA	NA	NA
AZP22904.1|10264689_10265565_+	alpha/beta fold hydrolase	NA	NA	NA	NA
10265320:10265334	attR	NA	NA	NA	NA
AZP22905.1|10265561_10266581_+	extradiol ring-cleavage dioxygenase	NA	NA	NA	NA
AZP22906.1|10267177_10268968_+	cation acetate symporter	NA	NA	NA	NA
AZP22907.1|10269055_10270216_-	amidohydrolase	NA	NA	NA	NA
AZP23776.1|10270480_10271227_-	IclR family transcriptional regulator	NA	NA	NA	NA
AZP22908.1|10271225_10271414_+	hypothetical protein	NA	NA	NA	NA
AZP23777.1|10271437_10272232_+	2-keto-4-pentenoate hydratase	NA	NA	NA	NA
AZP22909.1|10272228_10273179_+	acetaldehyde dehydrogenase (acetylating)	G9E526	Ostreococcus_lucimarinus_virus	1.3e-34	35.1
AZP22910.1|10273175_10274207_+	4-hydroxy-2-oxovalerate aldolase	E5EQ69	Micromonas_sp._RCC1109_virus	2.9e-37	30.6
AZP22911.1|10274613_10275399_+	DUF2993 domain-containing protein	NA	NA	NA	NA
AZP22912.1|10275938_10276574_+	ABC transporter ATP-binding protein	W5SAS9	Pithovirus	3.2e-10	30.2
AZP23778.1|10276624_10277731_+	polyprenyl synthetase family protein	NA	NA	NA	NA
AZP22913.1|10277912_10280543_+	di-trans,poly-cis-decaprenylcistransferase	R9W0U9	Flavobacterium_phage	3.6e-15	34.1
AZP22914.1|10280464_10280740_-	hypothetical protein	NA	NA	NA	NA
AZP22915.1|10281774_10283124_+	MFS transporter	NA	NA	NA	NA
AZP22916.1|10283505_10284453_-|transposase	IS481 family transposase	NA	NA	NA	NA
AZP22917.1|10284581_10284785_-	hypothetical protein	NA	NA	NA	NA
AZP22918.1|10284982_10285840_+	hypothetical protein	NA	NA	NA	NA
AZP22919.1|10286232_10287102_-	N-acetyltransferase	NA	NA	NA	NA
AZP22920.1|10287349_10288477_-	radical SAM protein	NA	NA	NA	NA
AZP22921.1|10288731_10288923_-	hypothetical protein	NA	NA	NA	NA
AZP22922.1|10288919_10289288_-	hypothetical protein	NA	NA	NA	NA
AZP22923.1|10289471_10289879_+	hypothetical protein	NA	NA	NA	NA
AZP22924.1|10289850_10290375_+	hypothetical protein	NA	NA	NA	NA
AZP23779.1|10290427_10291237_+	XRE family transcriptional regulator	NA	NA	NA	NA
AZP22925.1|10291246_10291429_+	DUF397 domain-containing protein	A0A1J0MBV2	Streptomyces_phage	8.5e-09	58.5
AZP22926.1|10293497_10295804_-	hypothetical protein	NA	NA	NA	NA
AZP23780.1|10297090_10297675_+	hypothetical protein	NA	NA	NA	NA
AZP23781.1|10298019_10298436_-	hypothetical protein	NA	NA	NA	NA
AZP22927.1|10298645_10299173_+	hypothetical protein	NA	NA	NA	NA
AZP22928.1|10299242_10300781_+|transposase	ISKra4 family transposase	NA	NA	NA	NA
AZP22929.1|10300770_10301100_-	hypothetical protein	NA	NA	NA	NA
AZP22930.1|10301204_10302638_-	hypothetical protein	NA	NA	NA	NA
AZP22931.1|10302974_10305344_-	hypothetical protein	NA	NA	NA	NA
AZP22932.1|10305359_10305581_-	hypothetical protein	NA	NA	NA	NA
AZP22933.1|10306491_10306779_-	hypothetical protein	NA	NA	NA	NA
AZP22934.1|10306921_10307962_+	hypothetical protein	NA	NA	NA	NA
AZP22935.1|10307958_10308708_+	hypothetical protein	NA	NA	NA	NA
AZP22936.1|10308712_10309372_+	HAD family hydrolase	NA	NA	NA	NA
AZP22937.1|10309736_10310934_+|transposase	IS3 family transposase	U5P429	Shigella_phage	3.1e-30	33.1