CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP034437	Paenibacillus sp. 18JY67-1 chromosome, complete genome	12 crisprs	csa3,cas3,DinG,casR,WYL,csf1gr8,csf2gr7,cas6,DEDDh	4	12	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP034437_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_1

578507-578780

Orphan

Consensus_repeat	Method
GCGCTTTTGGCAGGCTGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTGC	PILER-CR

2 spacers

The CRISPR arrays of CP034437_1

>merge|CP034437|1|578507-578780|PILER-CR
GCGCTTTTGGCAGACCGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTGCCTCCACTCTGCGGCCCGTTCGGCTTCTGAGAGAGGTTTTTTCCGCTCTTAGCGGGGAATTTCGCGCTTTTGGCAGGCTGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTAACTCCACTCTGCGGCCCGTTCGGCTTCTGAGAGAGGTTTTTTCCGCTCTTTGCGGGGAATTTTGTGCTTTTGGCAGGCTGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTGC

>CP034437|1|1|578507-578780|PILER-CR
GCGCTTTTGGCAGACCGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTGC	CTCCACTCTGCGGCCCGTTCGGCTTCTGAGAGAGGTTTTTTCCGCTCTTAGCGGGGAATTTC
GCGCTTTTGGCAGGCTGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTAA	CTCCACTCTGCGGCCCGTTCGGCTTCTGAGAGAGGTTTTTTCCGCTCTTTGCGGGGAATTTT
GTGCTTTTGGCAGGCTGAGAGAGGCTTTTTCCTCTCTCGGAGCTGGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN38689.1\|568122_568545_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
CP034437.1\|AZN38696.1\|579960_580638_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|185055
CP034437.1\|AZN43483.1\|568565_568979_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|225412
CP034437.1\|AZN38700.1\|587269_588190_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
CP034437.1\|AZN38691.1\|570623_571649_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
CP034437.1\|AZN43486.1\|580656_581463_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270429
CP034437.1\|AZN38699.1\|586017_587202_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|211420
CP034437.1\|AZN38701.1\|589229_589352_+\|DUF4023-domain-containing-protein	unknown	unknown	unknown
CP034437.1\|AZN38692.1\|571787_574160_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
CP034437.1\|AZN43487.1\|588245_589043_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
CP034437.1\|AZN38697.1\|581703_582933_+\|Bcr/CflA-family-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
CP034437.1\|AZN38695.1\|576787_578125_-\|arsenic-transporter	unknown	unknown	gnl\|CDD\|238538
CP034437.1\|AZN38698.1\|583099_585952_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|236848
CP034437.1\|AZN43484.1\|569511_570519_-\|thiazole-biosynthesis-adenylyltransferase-ThiF	unknown	unknown	gnl\|CDD\|181084
CP034437.1\|AZN38694.1\|576081_576759_-\|DUF2642-domain-containing-protein	unknown	unknown	unknown
CP034437.1\|AZN38702.1\|591129_591408_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN38688.1\|567541_567922_-\|holin	unknown	unknown	gnl\|CDD\|377457
CP034437.1\|AZN43485.1\|579180_579927_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
CP034437.1\|AZN38693.1\|574183_575773_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
CP034437.1\|AZN38690.1\|569028_569229_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN38689.1\|568122_568545_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.72861e-15
CP034437.1\|AZN38696.1\|579960_580638_-\|ABC-transporter-permease-subunit	gnl\|CDD\|185055	PRK15100, PRK15100, cystine ABC transporter permease.	7.36603e-85
CP034437.1\|AZN43483.1\|568565_568979_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	9.90002e-15
CP034437.1\|AZN38700.1\|587269_588190_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.6469e-26
CP034437.1\|AZN38691.1\|570623_571649_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	9.74519e-138
CP034437.1\|AZN43486.1\|580656_581463_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.99392e-123
CP034437.1\|AZN38699.1\|586017_587202_-\|hypothetical-protein	gnl\|CDD\|211420	cd11579, Glyco_tran_WbsX, Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases. Members of this domain family are found in proteins within O-antigen biosynthesis clusters in Gram negative bacteria, where they may function as glycosyl hydrolases and typically co-occur with glycosyltransferase domains. They bear resemblance to GH71 and the GH99 family of alpha-1,2-mannosidases and may share a similar cataltyic site and mechanism. The O-antigens are essential lipopolysaccharides in gram-negative bacteria's outer membrane and have been linked to pathogenicity.	3.01056e-100
CP034437.1\|AZN38692.1\|571787_574160_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	6.39288e-111
CP034437.1\|AZN43487.1\|588245_589043_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	5.06072e-29
CP034437.1\|AZN38697.1\|581703_582933_+\|Bcr/CflA-family-efflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.28685e-96
CP034437.1\|AZN38695.1\|576787_578125_-\|arsenic-transporter	gnl\|CDD\|238538	cd01118, ArsB_permease, Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.	3.52354e-103
CP034437.1\|AZN38698.1\|583099_585952_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	1.99089e-116
CP034437.1\|AZN43484.1\|569511_570519_-\|thiazole-biosynthesis-adenylyltransferase-ThiF	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	2.09474e-170
CP034437.1\|AZN38688.1\|567541_567922_-\|holin	gnl\|CDD\|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	1.77146e-29
CP034437.1\|AZN43485.1\|579180_579927_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.00756e-144
CP034437.1\|AZN38693.1\|574183_575773_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.6924e-60
CP034437.1\|AZN38690.1\|569028_569229_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	2.8684e-31

>CP034437.1|AZN38695.1|576787_578125_-|arsenic-transporter
MHDMMEILTVCIFFLTIGFIFWKPNINEAIPATVGAALVMLTGTVSLSDLGAITETISGAAITIMATIVMAIVLESFGFFNWSAEILTRRARGSGIRLFWLTNLFCFLMTLFVNNDGSILITTPILLMILKNMGLKNHQKIPYLLSGALIATASSAPIGVSNIVNLIALKIVHMSLYMHTAMMFVPASTGLLLLTFLLFAIFYRTLPKKLPDMPAWKLTPGGHPLQGEPSAPKINRNKLMRNILIFVFCVRVSLFVASFVHFPVSLMAVIGSSLLLAWRWFYLKVPPVDMLKKTPWYILIFAFSMYVIIYGLKNIGLTEWLIHFLHPIVSGSLLNASMLMGGLLSVLSNMFNNHPALMVGTLTLTNMGLDPLTLKISYLASVIGSDIGSLLLPIGTLATIMWMHIIKKGGVKISWGQYLKVTILVIPITVLFTLVLLNYWVTWLF
>CP034437.1|AZN38694.1|576081_576759_-|DUF2642-domain-containing-protein
MNEYASLIGEKVVLEISGKRLLPGRLIDVGSDIVVLLYQLRYLYIPFAHVHNLKADVSSGEGSESGSQAEEPSIGLLVDQLNVAKIMQEAKGLFVEIYVSGNKSIHGYLNGVMNDYFTLYSPIHGTIYVALSHMKWLIPYPTSHVPYARSTGTAPMGQTQPSLAKNFEGTLKKEEGKMAVIDLSGASERIAVIKGVAGGIINVIDADGNSTLLNIAHVKTMVVPK
>CP034437.1|AZN38693.1|574183_575773_-|GGDEF-domain-containing-protein
MIRTKGLSTRFMVSGIVVLSVLITVVISLITSYRSEKDSLIKMSFQMNSMYTGKIAATVNELFIAEKASMKAHAEYIARHWTQPEMDELTAYIQHSNAMFNTIIIIDKNGIMQSLSPEMSPPLKGKKITTPGTLQALKERMPLVSEPYISAANALIVLVSNPVYDANGEYLGFIGGTIRLHESNLLNAVLGSQQNAVAGNGSYSYVVSATGALLYHPDKDRIGEHILSNPLFSDLAAGRSGEKRITNSRGVDMLASYSYIKELGWGIVSQTPTSIVLKDAKRPMVHIATYVISIMLVILLAIYWVIGRMSQPLAKLAQYASLLSTTKSLHADVPRIHSWNSEANALHRAFVMAVSRIRMQLDHLSLEAQTDALTGLNNRRTMDKYIGTWLAREIPFTIMLLDLDHFKQVNDNYGHEKGDEVLKFLAANMRALFEGNHICCRYGGEEFVVLLPETSEDEAVRRANKLRRFMAETNSPVGRPVTLSIGLARYPDSAQDAEALFRSADEALYRAKHLGRNRIESASSAVVVS
>CP034437.1|AZN38692.1|571787_574160_+|EAL-domain-containing-protein
MPNVGIWVTMNLKGATTMDTRSQHAPLRYKTSRRIWLLILLITILLGSSFYWVTGAYSRWMHKDLDYDASVELGANASSLTLALERRMLLSDGLKAFVDTSLMNGSTLSHEQFDRFASNFVHTMQGIRNLSVYPGGIAEYVYPLASNESIIGLNLLAHKDLAIRENAERTKNTSQKTILGPIELTQGGLGILTRQSIFINNEFWGFVSIVLDVPPILAEAGVTNANKGIEMAVRANGRMIYGNRSLFERPSQLTTVNLSEGTWQLAAVPTTAKTKWIDTKIRFLRLLCSLGCALLIYIIYLQLTQKHKLLEMVKDRTGNLMTANTQLAATLDKLSEAEDQLRKQYLLLEGSERNLRKVAFHDTVTGLHNRMFFQDRLDSIIISHKSREERFALFFIDLDQFKLINDTLGHSYGDMLLQEVGQRLKQPLVQGEALSRIGGDEFTIILPMLSDLTQVHELAQQLVNLFYEPFLLQQVEYFVTASIGITIFPDHSQDADTLMKYADAAMYQAKEEGKNTYRIYDETLNADLQQKMYIKNSLRRALDHQEFEVFYQPQIELATGRITGLEALLRWTHPKIGPISPEVFIPIAEESGLMIPIGEWVLRTACAQSKAWQDAGLPPITIAVNLSARQFAPRYDLAAQVKAILAETGLDPACLELEITENMAMHDNNAAVLQELRSDNVRVSIDDFGTHYSSLSYLKRLPVDKIKIDRSFVIGIGKEPKDEAIILAMLLLAKHMELTIIAEGVETSEQLAFLQTGECHEIQGYFYYPPKSAETAQQILRSHAEGLTII
>CP034437.1|AZN38691.1|570623_571649_-|adenosine-deaminase
MNRWHLLPKVDLHVHLDGSLRPDTAMAIAAAEGIELPVRDEAGLIPYMQVDDDCRSLPEYLSKFDFTTRFMQSGAALERVAYETLAQAASHNCRYIEVRFAPQLHRSRGLQSDEAIHHVIAGMKRAEQEFDIVGRVIAICMRHHEQQANLDVIEAAAKFEGKGLVAVDLAGDEASFPPELFREVFALAHKRSLPVTIHAGEAAGAQNVYEAVKNLGASRIGHGVRLRENPAILQMILDQQIPLEMCPVSNIQTKAVADWDVYPIREYFEKGLLVTLNTDNPSVSGTDITREYRIVSERFDFTDSELAAIVRNGVNAAFLEDSAKKALKQRVEQDLAALGIQ
>CP034437.1|AZN43484.1|569511_570519_-|thiazole-biosynthesis-adenylyltransferase-ThiF
MLFPPIGVTGQQKIAAATVVVVGMGALGTVIANHMARAGVGKLRIIDRDYVERSNLQRQMLYDEGDVQQVRPKVVAAERKLARINSDIEIEPIVSHVTADNAEALIRGADLVLDGTDNFQTRLLLNDVCFKLGIPFIYGGAVSSHGMTAVFIPGQTSCLRCLLGSGDSGSGSSGGDTCDTVGVISPIIDIIASLQAVEALKFMVGAADAQRRGLLTLDIWQHQMMDMKLPPQQANCPTCRLKEYPSLHPQEAGHRSPVTLCGRETVQISGKQPLHLEQMAERLERSCSVTRNPYLLKAELPEGERLVLFADGRVLVQGTEDLARAQTLYDRYIGS
>CP034437.1|AZN38690.1|569028_569229_-|cold-shock-protein
MQQGTVKWFNAEKGFGFIEVEGGNDVFVHFSAIVGEGFKTLDEGQRVEFNVVQGNRGPQAENVVKL
>CP034437.1|AZN43483.1|568565_568979_+|ImmA/IrrE-family-metallo-endopeptidase
MEQIVCKLVRKHGTADPFKLAAHLKVNVQFLDLPDNCRGYYLRTLRRRFIAINRNLSDVWQRVVCAHELGHDQLHRGISRFFLDERSFFVAGRYETEANEFAVLLLLHNEQPDEGESIDTYFMRNHIPTELTRYYYQ
>CP034437.1|AZN38689.1|568122_568545_+|XRE-family-transcriptional-regulator
MLMDRLKQRRRAMNYTQEQLAELVNAKKTTISNYETGYSTPNNEMLSDLADVLQTTVDYLLGRSENPASLDAAGGSSAVIPDFATRKDVKDFKTFLNQQEVMFDGVPLTAEEKARVLGYMEGMFWDAKKMNKRSKPSSEG
>CP034437.1|AZN38688.1|567541_567922_-|holin
MLFLTALGGWDKALQVLLVIIIAEYITGLLRALKHGKVNADVLGWSVVRKVLILFVIGLASMLDGWNEHGTPIFRMAAIYFYCGREGLSLIEHLGANGIPLPRAMKEFLEQLSEQRDEKRSRKRRL
>CP034437.1|AZN43485.1|579180_579927_-|amino-acid-ABC-transporter-ATP-binding-protein
MIEVRGLTKAFGEQTVLKGVDLTLEKGSVLVVIGPSGSGKSTLLRCLNVLETPCSGTIAIGEANMAFTRGAKAKRSDVLTLRRQSGMVFQAYYLFPHLTALQNVMEGQLTTLRRAKEEAKERALALLTKVGLREKADAYPHQLSGGQQQRVGIARAMSIDPQLLLFDEPTSALDPELVREVLKVIRELAKEGRTMMIVTHEMKFAREVADRVILIDEGVIVEEGRPEQLFGDPQQERTQQFLSRLMDW
>CP034437.1|AZN38696.1|579960_580638_-|ABC-transporter-permease-subunit
MSDHSERLWHIFADSFLPLLRAGAAYTVPLTLISFALGLLLALATALVRLADIPVLSWIARFYVWIIRGTPLIVQLFIIFYGLPSFGILIDRFPAAIIGFTLSVGAYGSEIIRAAIISIPRGQWEAAYSLGQTRLQALRRIILPQAARVSVPPLSNSFISLVKDTSLAATVTVPELFAKAQQITAAVYEPMLMYCEVALIYLIFCTVLTVLQRMLERYYERFETR
>CP034437.1|AZN43486.1|580656_581463_-|amino-acid-ABC-transporter-substrate-binding-protein
MRYTGLAAVMLLSFTSACGKNESGNGNVAEAPGKTNLLESIKGSGEIKIGTEGTYAPFTFHDKDGKLTGFDVEIAEEVAKRIGVKPNFIETKWDGMLAGLDAKRFDMVANEVTIREDRQEKYDFSDPYILSKAVLIVKDSNTDIKKLADLKGKKSGQSLTSDLGDIAKGNGAELVPIDGFNQAIDLLVSGRIDATINDKLSFLDLKKQKPDVPIKVVDETNNASQSGLLFHKGNAELVSAVNKALSDMKADGKYLEISSKYFGEDVSK
>CP034437.1|AZN38697.1|581703_582933_+|Bcr/CflA-family-efflux-MFS-transporter
MINDQTTSLSAAMPRSRRLWTAVVLGSLSAFGPLSLDMYLPALPKLADDLHTSTSLAQLSLTACLIGLAIGQLFAGPISDVRGRRGPLLTGLILYAVSSLLCAIAPTIGTFIVLRFIQGLAGSAGIVIARAIVRDLYTGPELTRFFSLLMLVNGIAPIAAPIVGGQLLHFTTWQGVFIVLAAIGLVMFLAVLLGLPETLPKERRAKGGILNTVITFRRLLTDRVFMGYALAQGFVMAAMFAYISGSPFVLQDIYGVSPQMFSVCFAINGLGIILASQVAGRLAGRFNEAKLLVTGLGIAAVGGVALLAMLLAHARLVLVLIPLFFVVASVGLVSTMGFSLAMRNQGQAAGSASALQGLMSFMFGSIVAPFVGIAGSGTAIPMGLIIAALDVSALLLYFLLVRRAPAATA
>CP034437.1|AZN38698.1|583099_585952_+|hybrid-sensor-histidine-kinase/response-regulator
MLRDLILNFAILSVYLFFVSPFFIRDERSAKPTWKYKLTVGAVFGLLGIILLFFSITFNSNAPLNMRGIALMMASYFGGPLGAFAELIVVYIGRFLKEGSINPLQMAIGISAAIGTGYLFGRFKHYWTRWVIGSLFLLNYYYFALWLSNQITLETVWSYIISQACYSLFIAAFLYYLIHNHHNKKRIAQMEQDMISMLRMQPGLTFRIQRKHGTYYYNLAEGQLLKHLGLLPSMLFNKSFAETSLFQDDFADFLDNNYARFSSDETVSLETTMAGTAVHVTLQPVIQNGQLIDIIGNAIDITNLQKRKEADASNRAKSQFLAQMSHEIRTPINAIVGLNYILQQSRLDDQQRGYIDKIITAAKSLLTIVNDILDFSKIEAGKVVLEKVEFDLYEVLHNVSNMMSFKANEKGLRFHFFVHPDVPQMLVGDPFRVLQIVLNLANNAIKFTSQGQITISVNQIVERDQTSVLSFNVRDTGIGMNEEQLGSLFKEFTQADMTTTRKFGGTGLGLIISKNLAELMGGKIEVESKDGHGSSFTFKAPFTIAAAPAMAAQEVNPQLTFLRVLIICDDSQMQQVLRSQLEQFQFIVSNVNNGEDALQSIAHGGIYDLIFLDWRLDGADVLRLADTIHETFTSPSQSILLISAYHESELKMAVQSNSIVKALLHPISQSQLYDEIITLFRPHFSTNRSTSDYSIQFASLKDAAVLLVEDNEINQLVAKELLREVGIEADVASNGEIAVRYAAERRYDAILMDLQMPVMDGYEATKTIRQSANGKTIPIVAMTADAMKGVEDQVLSVGMNGYLTKPFDPIDLYSMLQRLLKQTREQASSAAALEAAAAKAEPHLDQASAIARLSGNSALYRQIIGLFINNHAFGLHLAREAFAAGDLKSAVLHVHTLKGVASNIGADQLAALMAKLQAALQAGDHAEASILQLEAELELQAVLLEASWIE
>CP034437.1|AZN38699.1|586017_587202_-|hypothetical-protein
MNLEELERQFARGYQPMSKRYEAAVYYFPNYHVDPRNEAWHGKGWTEWELTKRATPRFEGHDQPKVPLWGYEDEANPAVMARKIDAAADHGIDAFIFDWYWYEDGPYLDRALEKGFLEAANSDRLKFALMWANHDWIDIHPAQRSKPFNVLAEGTVSRAAFTEATDHMIRTYFGRSNYWRVDGKLYFSVYEMMSLVKGLGGIDATKEALDDFRVRVREAGLGELHLNAVVWGVQILPGEERISNPVEMITALGIDSVSSYVWIHHQELPVFPETPYSEIAEKSAGDWEKFSAAYGVPYLPNVTMGWDSSPRTVQSDVYENLGYPHMSMMAGNTPEQFRQSLEQMRAFLDRDINGFKAFTINAWNEWTEGSYLEPDTKHGMAYLEAVKRVFGGAE
>CP034437.1|AZN38700.1|587269_588190_-|AraC-family-transcriptional-regulator
MASIIGVSLLQLAPYVRYVHYNEGSEHYRVPRRVIYDYEFIYLTRGCAIFTLGDEEFLLKAGDLHVIPPFTVNACRVPQGGSFAYYACHFDPLYMGEEQNFSDEIYVDVDYANLPEVPVQEELLERPVLRFTDFELPPFVHCSTPHKVTGRFADLLALFNERPFGYQARVRACLLDIIGLLLEETHTAEGIKQDSPHKAMIAEMIGLMRHGSDTEFTVEGVARSYGVTTKYARTLFKQATGLSLSRYLATLRMERAKELLRRGGLSIAEVAAECGYEDLHYFSRLFKKHEGLPPRAYSDSLRGTSL
>CP034437.1|AZN43487.1|588245_589043_-|sulfite-exporter-TauE/SafE-family-protein
MLVLFALGLVASTFGAIVGLGGGVIIVPALLLLGPSMLGIDVDTTLAVGVSLGVLVFTSLSSTLTFMREGKTDLRSALFFAISSGPMSMVGASLTSLFNPDTFRRAFGIFMLLMVVLLLLRSRIKPYRGQWRYIRTYTDASGATQQYGYNALPALLIGGVVGLVAGLLGIGGGVLLIPAMLLLFSFPPHIATATSMGVIFISALLGSAVHLYRGEWDWVLVLSLAPGALIGGWLGAIISRRIGSVLLVRIMCAALLFFACRMILT
>CP034437.1|AZN38701.1|589229_589352_+|DUF4023-domain-containing-protein
MDQTSDFVNKLNDTQSKAEHNKKAKAPAKQLSNKQHSTNK
>CP034437.1|AZN38702.1|591129_591408_-|hypothetical-protein
MSDQINMQELVAFIAGKTKAAPASIEQVLKHEQAFINNAPEDKNGEVSIDSDELVDYILSRPGMKLDEPTVEDIIEAEMDYLMDKGIAGYED

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Crispr_ID: CP034437_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_2

1305720-1306028

Orphan

Consensus_repeat	Method
GTGNTGAGAGAGGGAAAAGCC	CRT

5 spacers

The CRISPR arrays of CP034437_2

>merge|CP034437|2|1305720-1306028|CRT
GGGCTGAGAGAGGGGAAAGCCTCTCTCAGAGTGCGAGAGCGGTGGTGTAGGCGGGTAAGCTGGTGTTGAGAGAGGGAAAAGCCGCTCTCGGGAGCCGGGGAAGGGGTAATCGTGTGTTGAGAGAGGGAAAAGCCTCTCTCGGTATGCGAATGTGGCCGAGTAGGCAGGTAAGGTGGTGTTGAGAGAGGGAAAAGCCGCTCTCGGCAGCCGGGGAAGGGGTAATCACGTGATGAGAGAGGGAAAAGCCTCTATCGGAGTACAAAAGCGGTGGTGTAGGCGGGTAAGCCAGTATTGAGAGAGGGAAAAGCC

>CP034437|2|1|1305720-1306028|CRT
GGGCTGAGAGAGGGGAAAGCC	TCTCTCAGAGTGCGAGAGCGGTGGTGTAGGCGGGTAAGCTG
GTGTTGAGAGAGGGAAAAGCC	GCTCTCGGGAGCCGGGGAAGGGGTAATCGT
GTGTTGAGAGAGGGAAAAGCC	TCTCTCGGTATGCGAATGTGGCCGAGTAGGCAGGTAAGGTG
GTGTTGAGAGAGGGAAAAGCC	GCTCTCGGCAGCCGGGGAAGGGGTAATCAC
GTGATGAGAGAGGGAAAAGCC	TCTATCGGAGTACAAAAGCGGTGGTGTAGGCGGGTAAGCCA
GTATTGAGAGAGGGAAAAGCC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN43547.1\|1316457_1318089_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270299
CP034437.1\|AZN39264.1\|1297688_1299284_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133005
CP034437.1\|AZN39271.1\|1309510_1310374_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN39266.1\|1300724_1303013_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
CP034437.1\|AZN39262.1\|1293004_1293313_+\|thioredoxin	unknown	unknown	gnl\|CDD\|239245
CP034437.1\|AZN43546.1\|1304572_1305634_+\|DUF2961-domain-containing-protein	unknown	unknown	gnl\|CDD\|378582
CP034437.1\|AZN39275.1\|1319288_1320185_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
CP034437.1\|AZN39268.1\|1306390_1307716_+\|M48-family-peptidase	unknown	unknown	gnl\|CDD\|320702
CP034437.1\|AZN39274.1\|1314128_1316432_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN39269.1\|1307660_1308491_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39267.1\|1303019_1304390_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
CP034437.1\|AZN39272.1\|1310565_1311663_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	unknown	unknown	gnl\|CDD\|239432
CP034437.1\|AZN39261.1\|1292317_1292995_+\|ribonuclease-H	unknown	unknown	gnl\|CDD\|260015
CP034437.1\|AZN39260.1\|1290928_1292317_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
CP034437.1\|AZN39259.1\|1290352_1290820_+\|archease	unknown	unknown	gnl\|CDD\|319352
CP034437.1\|AZN39263.1\|1293457_1297675_-\|collagen-like-repeat-preface-domain-containing-protein	unknown	unknown	gnl\|CDD\|375999
CP034437.1\|AZN39270.1\|1308576_1309458_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|366120
CP034437.1\|AZN43548.1\|1318342_1319272_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
CP034437.1\|AZN39273.1\|1311678_1314009_+\|glycoside-hydrolase-family-95-protein	unknown	unknown	gnl\|CDD\|379625
CP034437.1\|AZN39265.1\|1299372_1300494_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133005

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN43547.1\|1316457_1318089_+\|extracellular-solute-binding-protein	gnl\|CDD\|270299	cd13581, PBP2_AlgQ_like_2, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	6.15923e-165
CP034437.1\|AZN39264.1\|1297688_1299284_-\|glycosyltransferase	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	4.42753e-12
CP034437.1\|AZN39271.1\|1309510_1310374_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.629e-24
CP034437.1\|AZN39266.1\|1300724_1303013_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.67473e-116
CP034437.1\|AZN39262.1\|1293004_1293313_+\|thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	5.03851e-07
CP034437.1\|AZN43546.1\|1304572_1305634_+\|DUF2961-domain-containing-protein	gnl\|CDD\|378582	pfam11175, DUF2961, Protein of unknown function (DUF2961). This family of proteins has no known function.	9.07436e-127
CP034437.1\|AZN39275.1\|1319288_1320185_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.18145e-58
CP034437.1\|AZN39268.1\|1306390_1307716_+\|M48-family-peptidase	gnl\|CDD\|320702	cd07343, M48A_Zmpste24p_like, Peptidase M48 subfamily A, a type 1 CaaX endopeptidase. This family contains peptidase family M48 subfamily A which includes a number of well-characterized genes such as those found in humans (ZMPSTE24, also known as farnesylated protein-converting enzyme 1 or FACE-1 or Hs Ste24), Taenia solium metacestode (TsSte24p), Arabidopsis (AtSte24) and yeast (Ste24p). Ste24p contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is thought to be intimately associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. Ste24p is involved in the post-translational processing of prelamin A to mature lamin A, a major component of the nuclear envelope. ZmpSte24 deficiency causes an accumulation of prelamin A leading to lipodystrophy and other disease phenotypes, while mutations in this gene or in that encoding its substrate, prelamin A, result in a series of human inherited diseases known as laminopathies, the most severe of which are Hutchinson Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) which arise due to unsuccessful maturation of prelamin A. Two forms of mandibuloacral dysplasia, a condition that causes a variety of abnormalities involving bone development, skin pigmentation, and fat distribution, are caused by mutations in two different genes; mutations in the LMNA gene, which normally provides instructions for making lamin A and lamin C, cause mandibuloacral dysplasia with A-type lipodystrophy (MAD-A), and mutations in the ZMPSTE24 gene cause mandibuloacral dysplasia with B-type lipodystrophy (MAD-B). Within cells, these genes are involved in maintaining the structure of the nucleus and may play a role in many cellular processes. Certain HIV protease inhibitors have been shown to inhibit the enzymatic activity of ZMPSTE24, but not enzymes involved in prelamin A processing.	2.69319e-104
CP034437.1\|AZN39274.1\|1314128_1316432_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	5.46009e-22
CP034437.1\|AZN39272.1\|1310565_1311663_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	gnl\|CDD\|239432	cd03316, MR_like, Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).	2.69459e-121
CP034437.1\|AZN39267.1\|1303019_1304390_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.83505e-82
CP034437.1\|AZN39273.1\|1311678_1314009_+\|glycoside-hydrolase-family-95-protein	gnl\|CDD\|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	5.16333e-47
CP034437.1\|AZN39261.1\|1292317_1292995_+\|ribonuclease-H	gnl\|CDD\|260015	cd13935, RNase_H_bacteria_like, RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. This family includes bacterial ribonuclease H (RNase H) enzymes. RNases are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.	4.025e-65
CP034437.1\|AZN39260.1\|1290928_1292317_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.82163e-57
CP034437.1\|AZN39259.1\|1290352_1290820_+\|archease	gnl\|CDD\|319352	cd16352, CheD, chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins. This family contains bacterial chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). The CheD chemotaxis gene is not found in the Escherichia coli genome, but is present in many other organisms, including B. subtilis, where CheD appears to have two separate roles; it binds to chemoreceptors to activate them as part of the CheC/CheD/CheYp adaptation system, and it deamidates selected residues to activate chemoreceptors, enabling them to mediate amino acid chemotaxis. CheD has been shown to catalyze amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptors McpA, McpB and McpC; deamination by CheD is required for the chemoreceptors to effectively transduce signals to the CheA kinase. CheD's ability to bind the receptors is controlled by CheC via a competitive binding mechanism; substituting Gln into the receptor motif of the signal-terminating phosphatase, CheC, turns the inhibitor into a receptor-modifying deamidase CheD substrate. Also, CheYp increases the affinity of CheD for CheC, controlling CheD binding to the receptors through its interactions with CheC. Thus, high levels of CheYp means CheC is a better binding target for CheD than the receptors, resulting in decreased CheA activity. The CheD structure reveals a distant homology with a class of bacterial toxins represented by the cytotoxic necrotizing factor 1 (CNF1) as well as a class of proteins of unknown function represented by B. subtilis YfiH. An invariant Cys-His pair forming a catalytic dyad is observed, and is required by the toxins for deamidation activity.	7.39749e-40
CP034437.1\|AZN39263.1\|1293457_1297675_-\|collagen-like-repeat-preface-domain-containing-protein	gnl\|CDD\|375999	pfam18573, BclA_C, BclA C-terminal domain. This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.	9.53484e-31
CP034437.1\|AZN39270.1\|1308576_1309458_+\|ROK-family-protein	gnl\|CDD\|366120	pfam00480, ROK, ROK family.	5.29087e-73
CP034437.1\|AZN43548.1\|1318342_1319272_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.01751e-121
CP034437.1\|AZN39265.1\|1299372_1300494_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	6.84047e-50

>CP034437.1|AZN43546.1|1304572_1305634_+|DUF2961-domain-containing-protein
MGIGNLARLSNAKTRSISPENFSGEPGKGGMATEGTGKNCARDLGQGWKVSPSVEIEPGATLTMADIKGPGAIQHIWLTCFPGSWRNMIIRFYWDNEETPSVEVPVGDFFCNGWQERCNVNSFPIAVNPAGGMNSYWQMPFRGSARVTMENTSKTDKAVLYYQIDYTLTDVPEDMAYFHAQWRRSNPVAYKDVHTLIDGVTGKGHYVGTYLAWQVNNTGWWGEGEIKFFMDGDTEFPTICGTGTEDYFGGAWNWEHPQGQYGVYSTPFLGMHQVIKPDGLYRSQQRFGMYRWHVQDPIRFDSELRVTIQDLGWRSGGRYLPQQSDIASTTFWYQAEPHAPFPELPGNDEREVI
>CP034437.1|AZN39267.1|1303019_1304390_+|sugar-ABC-transporter-substrate-binding-protein
MGETVKGRMQLLLGLLVAATVMATGCSAKDAQSTGGSKDVRAVGSEAGNGAAAKGDVKLRMMESLTNPKRTEILKSLIAQFEQENPSIHVELISPPFNQADETIETMLSTKQNLDVIEVREINVADYVKKQYIEPLDAYTASWQDYATVQQIPLSVGSVNGKLYFLANGLYERQLYYRKDWFDQAKISPPSTWDELYNAAVKLTNQARNQFGFSFRGARGSNGVFDGMIRTYNGAATDLADGAFLNSGSTIYSTPEASEALTLYKKLYDHASPKESVYWGFDEQVKAFTSGQTAMLLQDSDVIQTLQAEMKPGTWAAVPMPKGPSGKSLITVGAAGWGISSSSSHKAAAWKLIAFLSSPDQNTEFGKKYGLVPIHTTVSTDPYFTTGPYKTLIDMTNDPDTYLYYQTPIKYPGNNEWSKVSTSTEQEMLLGKATVQETLVKWDAFWKEQQRLIQGK
>CP034437.1|AZN39266.1|1300724_1303013_+|EAL-domain-containing-protein
MKQSFKPFMFILFISTVLVAGISLYSYSQSKVILKERMTLSTQQTVIQTVDELNLMLRAYEDLTYNVITDAGILSNLQIYGDTQGDQLDRFNAANQIKSILSVRFFSKADIKDVHLFPLDSPVNEISTVGPSESRLSYVNSDWYKQAIAGDGRNVWLETRRTGFLGSGQPTFAISRVVTLISGMKFILFVEISTEDVNDMLAEAHLGKTGEMVLLNDANLLLSQSRQGVTGAKYRIPLLAPDKADPDESKYLMRSAVNRIDGKQQLIVTGKLASTGWTVEAFVPVSELIQDTAKLRNTMLLCIIVIGFVTFLVNYLYQRRRSSAAIRYMAYHDHLTDLANRKLFSELLDREIMISKQQGLRFAVLFIDLDRLKLINDTFGHGAGDKLLIDIATKLKRQLPKEYTTARFGGDEFLILMPNIKNDTEVEEMLHKLAALIQEPIYYQDKELYCSASIGVSIYPQDGEDGSSLIKNADMAMYSVKESGRSNHRFYDSEMDKKSYGKFELERDLRKALEREQLLLVYQPQVHVESGAIVGVEALVRWKHHERGMISPADFIPIAEETRLIIPIGEWILYTACRQNKAWQEAGLSPVHVSVNLSIHQFQSPGIVENVAHILRETGLAPQWLELEITESIAMHDVEQVIRTLQGLSDLGVKISIDDFGTGYSSLSYLKNFPIERLKVDKSFLDNMIESPKERAIVGSIIVMSHSLGLKVTAEGVEKVEQVQLLQELSCDDAQGYYFSRPLLPDDCAKRLAENAIYAGGR
>CP034437.1|AZN39265.1|1299372_1300494_+|glycosyltransferase-family-2-protein
MIAISLCLIVKDEEDVIARCLDSVKKAVDEIVIVDTGSTDATKDIAATYTDKIYDFEWIDDFAAARNYAFSKATSAYILWLDADDVLLEPDLKKLLELKSTLSSDVDTVSMDYHLAKDEYGTVTSALRRNRLVKRERGFRWIGAVHEYLEVYGASYASDIAVTHASLRHDSDRNLRIYEQRLARGESFSARDRFYYANELSDHARHEQAIMSYSRFLLSGEGWVEDNIAACGKIADCYSALGADDLALEYALRSFKYGSPRPDFCCRIGYWHLQKGSYAIAAYWYEAALNAPKQEQSWSLHNNACATWLPHLQLCVCYDKLGDLARAFVHNERARAYRPADAAVLHNKAYLEEVLKAKASALEENAYPVDASV
>CP034437.1|AZN39264.1|1297688_1299284_-|glycosyltransferase
MCLTVRRILIGSPIRQKPEILTLFLQSLERLRHATWQADYVFIDDNEDAASVLLTQFTEAVHAQGSSTVRLIAGSKTSSAYKRDEITHYWNDELIGKVADWKDHFIQMAREEQYDALFLVDSDLLLHPETMESLLEADKPIISAIFWTRWQPDGAELPQVWLKDHYWPWQTDDDSADVQQERLKLMTKLRLPGVYDIGGLGACTLISREALEQPISFRMIPNLSLWGEDRHFCVRAASLGIGLSVDTRYPAFHIYRDTDMPRALQYFRYTASEVQEPRRSPHFFVRNAGPKLVLSMTARNEEGRYLDEALLRHREYIDAAVIIDDGSTDATKEIIHERLDGIPLFYVRNEVSRFANEIELRRQQWDATVGLRPEWILNLDADEYFEDRFAVEIASLLENPLASCYLFRLYDFWNERQYRDDQYWQAHHTYRPFLARYTPGYPYQWNEARQHCGRFPNNIFDPPPHLSSLRLKHFGWAREADRLFKAARYAELDPEAKYGWQEQYDSILGVPHLVDWQENELAPSAIETASS
>CP034437.1|AZN39263.1|1293457_1297675_-|collagen-like-repeat-preface-domain-containing-protein
MPDNNDNSSDSQSNRNLRSSNNNASIPVTQSQLNKMKQLLGQLAGLLSSVLAAPSLSGIKQLDGLLHELRSLVLQIDFTRSEQASLLSLLENEITLVEASPFSPLGAAVLSADLLNLLGSVILLFAIQPSDKDALISLIRANEQQLAAIFALLGSQSEYVGSPGPPGPPGPPGPPGAGGPAGSPGQPGSAGPAGAPGPAGAAGAQGPTGATGAGFVGITTYNPANSPTYPLGQSVTYAGSTYVALVASPSGTPGSSPDYLLVAASGANGSTGATGGTGNTGATGSTGADGTTGAAGSTGATGSTGATGAGETGATGSTGAGGATGAAGSTGATGSTGATGAGETGATGSTGADGATGAAGSTGATGSTGATGAGETGATGSTGADGATGNTGPTGATGATGAGETGATGSTGADGATGNTGSTGATGATGAGDTGATGSTGADGATGSTGATGATGATGATGATGATGATGATGAGATGSTGSSGATGATGAGLTGVTAFNPANAPTYPAGQVVTSDGSTYIALVAAPTGTPGTSPDYLLLAAAGATGTTGSTGSTGSTGVAGATGSTGANGATGSNGATGVTGATGVTGPTGSTGAGLEGVTAFNPANAPTYPAGQVVTSDGSTYIALVAAPTGTPGTSPDYLLLAAAGATGTTGETGATGSTGSTGVAGATGSTGANGATGATGSNGATGGTGATGVTGPTGSTGAGLEGVTAFNPANAPTYPAGQVVTSDGSTYIALVAAPTGTPGTSPDYLLLAAAGATGTTGATGATGSTGSTGVAGATGSTGANGATGATGSNGATGGTGATGVTGPTGSTGAGLEGITAYNPANAPTYPAGQVVTSDGSTYIALVAAPTGTPGTSPDYLLLAAAGATGTTGETGATGSTGSTGVAGATGSTGANGATGATGSNGATGVTGATGVTGPTGSAGAGLEGITAFNPANAPTYPAGQVVTSDGSTYIALVAAPTGTPGTSPDYLLLAAAGATGTTGETGATGSTGSTGVAGATGSTGANGATGATGSNGATGVTGATGVTGPTGSTGAGLEGITAFNPANAPTYPAGQVVTSDGSTYIALVAAPTGTPGTSPDYLLLAAAGATGTTGATGSTGDTGVAGATGSTGANGATGSTGATGATGSTGATGSTGSTGATGSTGNTGATGSTGNTGATGTTGATGATGAGLEGVTAFNPANAPTYPAGQVVTSNGSTYIALVAAPTGTPESSADYLLLAAAGATGATGATGSTGATGATGSTGATGATGVTGTTGATGATGTVFTNINSFAANTGGGVIAVVLGGTNVPLPNNQILNGGITVNGANDTFTVPSAGSYMISYQANLTAALLLSTRLLINGTASTPSVVAPVLSVSEFNNMVILTLTAGTTITLQFFGLLGAATLISGGAGAALTIVKLS
>CP034437.1|AZN39262.1|1293004_1293313_+|thioredoxin
MVMKEITEQQWLQRDIAPKGKEAVFFFTPLCGTCKVGLRMLEVAEAAGISTSVFLININFAPVLREKWKVASVPCLVLTQAGEPVQMEYAMQSVDTLYRLLK
>CP034437.1|AZN39261.1|1292317_1292995_+|ribonuclease-H
MAKQKFYVVWVGRKPGVYTSWADCQLQTNGFDDAKFKSYESRAAADEAYQGGWKKHWGQGSAGASSGGGSSSGGKSSFYKRKSPSAEEIGEIDYNSISVDVGTNGNPGPVEYKGVDTQTGEVIFAVGPIAKGTNNLGEFLAIVHGLAHLKKLGSNKTVYSDSVNALKWVREKAVSSTLVRDDSTAEIWLMVDRAIRWLQTNTYSNKVLKWHTKQWGEIKADYGRK
>CP034437.1|AZN39260.1|1290928_1292317_+|sensor-domain-containing-diguanylate-cyclase
MLIWILLLLIFISILTAALLWSRFYRVQAKLESVQQEYTDLLRKQQGITFKAKKINGEYFYTMIEGNLYYMLGQTQSDVGKRMEDLIPSHQQDLIRHNYDRVWAGETVQYEYSLNGYTCLFSLTPVKENGETVELIGVGSDITERKKAEQAMQESESRYRQLVELSPDAIFVVTNRQIVFMNKKAMTVLGGSSLEQFLARPIQENVHLEFRSRARQHLQQVLDTEGVLQPYESKYMKLNGEPIDVEVTAAYMLYQGASSVIIIFRDITERKLAEQQLQESNVQLMKLVSLDGLTGIANRRFFDEMMEKEWELALSGELPLSIILCDIDYFKAYNDTYGHQEGDSCLKLTAAVLDKIAQPNGGFAARYGGEEFIILLPETGPEEAAHIGFQLCEAVKALGIPHGASLVSPVVTICAGVTSFTPSAVDEMDELIRQADTALYQAKQSGRNRMQLYDVSWMKEGV
>CP034437.1|AZN39259.1|1290352_1290820_+|archease
MNKVVGLGEWKSSNNKIDTIMTFALSTCVAVTAYCPIKRAAGLVHIVLPEPLLSRDEQKRPGHFATTGVPLLIQMMVEKYGCRKADLIIQLFGGAEPKRRDYYRIGSRNLEQIQSMLTRLQVRAVKSEVGGQVSRTLHMSVETGEVTLSTLPLSS
>CP034437.1|AZN39268.1|1306390_1307716_+|M48-family-peptidase
MPRSRRSKGFVWFIWFVVYAALVTAYVWYTSPNNVPSSYAGTAADPATFFSSKQLADSARLNAMRNWIFFISAPWEWLIYLFLLFGGLARYWRDALESWRLPLVVRFPLYVLLVDAAAFVLYLPLRALSFALSKSYGISTQPWPGWIRDKLVAFGVGYVTLLAVTAVAFWIMSRRGRWWLKLWLISVPFTVFMMYVQPVIIDPLYNHFTRLSDPQLEQKILALAAKSDIPASRVYEVDMSAKTNAINAYVTGIGSSLRIVLWDTTLKQLNEQEILLIMAHEMGHYAMHHLEWSAVGAVGSSLVVIVIGGWIYIWSIRRFGDRLGIRGRADITALPLLLLILSLLSFASLPVSNYVSRQAESAADAYAMDLLGTADGSISMQQKTALITLSDLNPPLLVRWFRDTHPSDMERIVAAMKFAKEHPHAAEADAGAAHKGASSSD
>CP034437.1|AZN39269.1|1307660_1308491_+|hypothetical-protein
MQQRLTLALLTKGHLRVTSGAAKGEVSLYLLSGIATAPRFMEGFRSALHGALRREGYEVATSELMFPYGNWSRRIVPQLWEIGRDMRRNPRKTGRSIGGRRAIAAIGESRRSLGLSASSGKGRTILVGHSGGGVAAVHAAMQLIEQDGEAPSPLVVMIGSPRCRIPEQLRHSVLYVYATPPGTSTGSGRISDAICKLGSFGGWGGGSDVDFAGRASRRSFPGWNHNKYGPGGACGVPIIGWHPDYFREQPPYVNRMGLSNQWLTLHAVWEWLRGKI
>CP034437.1|AZN39270.1|1308576_1309458_+|ROK-family-protein
MLIGAVEAGGTKFVCGIGSEDGFIQDRVSFPTEAPEKTIANVINYFRDKKVEAIGIGSFGPINIDPTSPQYGYVTTTPKPGWGNYPVLPELRKVFDVPFGWDTDVNAAALGEATWGAAAGLDSCLYYTVGTGIGVGVYAEGKMVHGLVHPEGGHVLTRRHPEDTFEGFCPYHGDCLEGMAAGPAIERRWKVKGSELGVDHPAWEMEAFYLGQAVANAILLLSPKKIILGGGVMHQEQLFPLIHAEVRNNLKGYVSAEAVLDGISSYIVPPGLGDNAGLCGSLALGLRALQEAK
>CP034437.1|AZN39271.1|1309510_1310374_-|AraC-family-transcriptional-regulator
MRTLAELTPFVGDSMPYLYDGSSNEGLRVCSVFAFHLFTDGPGEMEIEGTRYPIEKRTLIFLRPGQPHAFHISPEHPLASHNLYCDLWDNRMPISLHRTFIYAPSPFRLPEQSASEPCDELDALPGVFSLQPYPHLYEAFLHIVKLYNELIHYRSETVNSLLYAWMLSWHNACRTRQPRDYRIVRLLEQLEMNPERRETVEQWWTLCGLKRTYFHELFLRETGMTPKAYQHRLLMKRAMHLLQESDLSVTAIADKLGYPSIHPFTRHFTAHYGVSPKQHRQNPHKKR
>CP034437.1|AZN39272.1|1310565_1311663_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein
MLITKVETFVLHVPITPPITDAINVATHWGLSGVRIYTDEGITGWGYTGTCAHGDDMIVDTIERYYAPELIGKDPFMVKELWDTMRFGKMHWIGRAGITHMALAAVDIALWDIMAKASNKPLWQYLGGHKSKGIKAYNTNGGWLNWSKDRLLKDVTDIVEQGFTGVKIKVGKPDPREDYDRVKAVRQAIGDDVIFMIDVNQQWNINTAMTWGKRLEEFDLFWLEEPLNPDDIMGHKKLADELNVPIALGEHVYTKYAFRDYIHQGALEYCQVDVTRVAGVTEWLQVAGLAAAYDVPVCPHVGDMGQIHQHLVAATPGAIMLEYIPWIRHIFEEPATVQNGLYVLPQMPGASTKMIPKYFDEYRVR
>CP034437.1|AZN39273.1|1311678_1314009_+|glycoside-hydrolase-family-95-protein
MKLRYEGAAPGWKQGLPLGNGRLGAVVYGDGVSETWCITELTYWSGKQEAPMTASQGKSDLAAMRELFYAGNYAEGEEMASRLLQAEKRNFGTNLSLCDVRLSFEGGDKGNAMTRELSLEEAVYRAESVVGDDSNSNLLLIRETLASHPSNVIASHIRREGAAGITFTLRLEGRTERFDVHAAGEDMLTFESQATETMHSDGTCGVWCKGAVHVVAAGGSIAVQDGAIVVECADEAWIYFAAETDYRREDHAWEQEAASRVKQAAELGYAEVREAHIADYRQLYGRVEADFGDSGASALPIDERVRLLRAGGDDPQLFALFFQYGRYLMIAGSRADSPLPMHLQGIWNDGEANRMAWSCDYHLDVNSEMNYYPAEGANLAECHLPLMRYIERLAEAGRETARSYYGCEGWTAHVFSNAWGFTEPGWHYSWGLNVTGGLWIANQLREHYEYGRSESFLRESAYPVLKEAALFFLDYMTVHPKYGWLVTGPSNSPENSFYIGGSQDRSYALSMGPTMDQSLIRDLFTFCAEASERLGVGEPLRERLQQAIKLLPPLQVGRSGQLQEWLEDYGEAQPDHRHLSHLYALYPGNQITPHGTPELSDAAMQTLTMRMRDEGLEDVEFTLALFAANFARLHEGNRAYDQLSYLIGELCFDNLLTYSKAGIAGAETNIFVADGNFGAAAAVIEMLLQSHASEIHLLPALPEQWHTGRITGLRARGNAEVDMVWQGGELSEATIRAHAPLQTMVRYGERTMPIKLAAGESISLSRGAFATEEQMR
>CP034437.1|AZN39274.1|1314128_1316432_+|helix-turn-helix-domain-containing-protein
MNKHSRIFRSFLISYIVILIIPSLAGYMSYRTSIAVTQSISIENSVTLLQKSQQMLERRMAEVEGFTRQLALNQDLYVLMNQKKRSSSDDGNVYDIWKIMKEVMVFSQTNDFLKNYYIYLRNYNVVLTPGSAYFRPEHYYDSAHYTKMNMLQWKSLIMDNTHSREVMPLKPFSLNGNPTSVISYMQSLPLDSFGEQAPATVVVLIDQKTIASLLSGVQERYGGWTYVSNAEGDAISMLGIGEQEASAMNADSAFNKEKQSQFYKDDLVITTRSASTGWIYRAGIPRSALMENANYIKYISWSVTGAALIIGLVVGWILSRRNSAPINRLLGVMREQFGKDEPIGRNEYDFLQGNISTIITSNRALEQELNRQLPLIRDAFLKRLVAGEFQTLEEIAAAASQADTGLSLNEGYVGILHIHGYAGLDSVEILNELSAARLLLRQSLRDIDGRILMTDLGSDRVVAIFPAVCETTDEQTSRANIEQLLEPFAALMFSEYKITVTGSFGDPFTSEMEVSRSYEQAKETMGYADYTQRKGFLWYANIRQESATYYYPLDMELRLISTVRAGEEAEAKRIVGSVMQQNTEDRELSPEMANQLIVELKGTLLKLLDQKAFAESEQFEEVKNRVLEIQLAGAIDTVRGELDRIIEAMCGMITSKKNDLHIKTVEQIKQFIAQQYGDSELTLYRIAEQAERPEKYISQLFKEVTGTNLSDHLEKVRMDRAAELLQDKSFTVDEIALQVGYNSSHSFRRAFKRVMGVAPSAYRQSLD
>CP034437.1|AZN43547.1|1316457_1318089_+|extracellular-solute-binding-protein
MKLRLIIWMLMSCMLLSACSSEAPKQQTPQQESTSITVFAQQDSGQNLQTSAFSAYLENTYGVHFNWETIPYEGAKEKRQISLASGSYADTYILTAYIDQFSKAEVLRYGKQGIFLPLNDLIDKYAPHIKAAFKQNAELRELNTAPDGNIYGLVSYSECFHCSYPNKMWLNKVWLDKLHLKMPKTMDEFKKVLEAFKTEDPNGNGIADEIPLSGSTESFGVHLIPFLMNGFIYDDDRNYLALSGGKVDTVANKQAWKEGLAYIKSLYEEGLIDPGAFTQNSEAYKRLGDNEGDVILGAGAAMHPDIFASDATGSNRSRNYAPVPPLKGPHASYTVHDEGGINPGAKFVITNKATREAQIALIRMVDYMYTPEGQLHGESGDEGVGWRKPLPGELALNKAAVPMKAGIPSTPSKPNNSGWVGTAHFYMPKSYRDTWVQDTDMYAPNGYERRLQAATELYAGKEPKELFPAWAIWVSEADAQRASVLETNLKNYIDQNTLEFITGSQSLDTDWNSYVSGLSEMGLSDYLSIMQQGYDDYLNNRTK
>CP034437.1|AZN43548.1|1318342_1319272_+|sugar-ABC-transporter-permease
MKRNKRSLSSAAARSFAKHWQLYLVVIPPLLYFIIFKYYPMLNAVLAFKDYNVIKGIWGSPWVGMKNFKLFFDNPTFWDLIKNTIYLSGYLLLAGFPIPIALALMLNEVRSSRFKRFVQLVTFAPYFISTVVMVSIIMLFLAPRLGFVNVLMNHLGLDSINFLGVPSMFRSIYVWSDIWQTAGYSAVIYLAALAGIDPTLYEAAKVDGASRFQKIWHVDLPGILPTITIVLILNVGNIMAVGFEKVYLLQNPLNLVNSEIISTYVYSIGLLNANYSFATAVGLFNSVINLVMLVLVNSLAKRFSNNSLW
>CP034437.1|AZN39275.1|1319288_1320185_+|carbohydrate-ABC-transporter-permease
MSSKRTTIRESAGDRLFMLVIYTILTLVLIAVIYPLIYIVSSSISSPAAVTSGKVWLWPVDISFKGFETLLHTPQIVTGYGNSLFYTAAGTLISVALTVMIAYPLSRKTFFGRSGIMMIITFTMIFSGGLIPTYMVVRALHLIDTRWALLIPNAIWVWQVIIARSFFMSSIPEELIEASEIDGCSDLRFMRSVVIPLSKPILAVLVLMYAVGQWNAYFDALIYLKSAKLFPLQLILRSIIIQNNSSGVMDAMKMVERQQLAELLKYALIVIATLPVLIIYPFVQRFFVQGMLVGSVKG

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Crispr_ID: CP034437_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_3

1510441-1510623

Orphan

Consensus_repeat	Method
GAGAGAGGCTTTTCCCTCTCTC	PILER-CR

3 spacers

csa3

The CRISPR arrays of CP034437_3

>merge|CP034437|3|1510441-1510623|PILER-CR
GAGAGAGGGAAAAGCCTCTCTCCGACGTGAAAAAGAGGCAATTTCCCGCTGAGAGCGGGAAAAGCCTCTTTCGTTGATCGAAATCGTTGTGATTGGTTCGATTTGCTCTTAGAGAGAGGGGAAAGCCTCTCTCAGTTTGAATTTTGCGCGAATCTGGCGCTGGGAGCGGGAAAAGCCTCTCTC

>CP034437|3|2|1510441-1510623|PILER-CR
GAGAGAGGGAAAAGCCTCTCTC	CGACGTGAAAAAGAGGCAATTTCCCGCT
GAGAGCGGGAAAAGCCTCTTTC	GTTGATCGAAATCGTTGTGATTGGTTCGATTTGCTCTTAGAG
AGAGGGGAAAGCCTCTCTCAGT	TTGAATTTTGCGCGAATCTGGCGCTGGG
AGCGGGAAAAGCCTCTCTC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN39415.1\|1519837_1521292_+\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
CP034437.1\|AZN39400.1\|1500200_1500884_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
CP034437.1\|AZN39404.1\|1505061_1506228_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|377924
CP034437.1\|AZN43571.1\|1512754_1513651_+\|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|226652
CP034437.1\|AZN39409.1\|1514758_1515763_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381319
CP034437.1\|AZN39412.1\|1517233_1517791_+\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|285278
CP034437.1\|AZN39403.1\|1503346_1503979_-\|methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|377428
CP034437.1\|AZN43570.1\|1508789_1510301_+\|glycerol-kinase	unknown	unknown	gnl\|CDD\|198361
CP034437.1\|AZN39410.1\|1515847_1516714_-\|aldose-epimerase	unknown	unknown	gnl\|CDD\|185702
CP034437.1\|AZN39405.1\|1506297_1506690_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319909
CP034437.1\|AZN39414.1\|1518915_1519806_+\|copper-oxidase	unknown	unknown	gnl\|CDD\|259929
CP034437.1\|AZN39399.1\|1499735_1500023_+\|small,-acid-soluble-spore-protein,-alpha/beta-type	unknown	unknown	gnl\|CDD\|365990
CP034437.1\|AZN39407.1\|1511000_1512509_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
CP034437.1\|AZN39406.1\|1506885_1508757_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
CP034437.1\|AZN39413.1\|1517787_1518735_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372574
CP034437.1\|AZN39401.1\|1500880_1502386_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|274368
CP034437.1\|AZN39402.1\|1502491_1503319_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238362
CP034437.1\|AZN43569.1\|1503975_1504851_-\|bifunctional-5,10-methylenetetrahydrofolate-dehydrogenase/5,10-methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|223268
CP034437.1\|AZN39408.1\|1513671_1514661_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223971
CP034437.1\|AZN39411.1\|1516916_1517237_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN39415.1\|1519837_1521292_+\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.37296e-64
CP034437.1\|AZN39400.1\|1500200_1500884_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	8.07273e-80
CP034437.1\|AZN39404.1\|1505061_1506228_-\|copper-amine-oxidase-N-terminal-domain-containing-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.65749e-11
CP034437.1\|AZN43571.1\|1512754_1513651_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|226652	COG4189, COG4189, Predicted transcriptional regulator [Transcription].	1.0118e-123
CP034437.1\|AZN39409.1\|1514758_1515763_-\|aldo/keto-reductase	gnl\|CDD\|381319	cd19093, AKR_AtPLR-like, Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins. Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.	7.89638e-105
CP034437.1\|AZN39412.1\|1517233_1517791_+\|DUF1700-domain-containing-protein	gnl\|CDD\|285278	pfam08006, DUF1700, Protein of unknown function (DUF1700). This family contains many hypothetical bacterial proteins and putative membrane proteins.	2.32859e-50
CP034437.1\|AZN39403.1\|1503346_1503979_-\|methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|377428	pfam04961, FTCD_C, Formiminotransferase-cyclodeaminase. Members of this family are thought to be Formiminotransferase- cyclodeaminase enzymes EC:4.3.1.4. This domain is found in the C-terminus of the bifunctional animal members of the family.	5.24675e-53
CP034437.1\|AZN43570.1\|1508789_1510301_+\|glycerol-kinase	gnl\|CDD\|198361	cd07786, FGGY_EcGK_like, Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of mostly bacterial and archaeal glycerol kinases (GK), including the well characterized proteins from Escherichia coli (EcGK), Thermococcus kodakaraensis (TkGK), and Enterococcus casseliflavus (EnGK). GKs contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The high affinity ATP binding site of EcGK is created only by a substrate-induced conformational change, which is initiated by protein-protein interactions through complex formation with enzyme IIAGlc (also known as IIIGlc), the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS). EcGK exists in a dimer-tetramer equilibrium. IIAGlc binds to both EcGK dimer and tetramer, and inhibits the uptake and subsequent metabolism of glycerol and maltose. Another well-known allosteric regulator of EcGK is fructose 1,6-bisphosphate (FBP), which binds to the EcGK tetramer and plays an essential role in the stabilization of the inactive tetrameric form. EcGK requires Mg2+ for its enzymatic activity. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
CP034437.1\|AZN39410.1\|1515847_1516714_-\|aldose-epimerase	gnl\|CDD\|185702	cd09025, Aldose_epim_Slr1438, Aldose 1-epimerase, similar to Synechocystis Slr1438. Proteins similar to Synechocystis Slr1438 are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	1.17384e-86
CP034437.1\|AZN39405.1\|1506297_1506690_-\|glyoxalase	gnl\|CDD\|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.41016e-27
CP034437.1\|AZN39414.1\|1518915_1519806_+\|copper-oxidase	gnl\|CDD\|259929	cd13860, CuRO_1_2dMco_1, The first cupredoxin domain of bacteria two domain multicopper oxidase. This subfamily includes bacterial two domain multicopper oxidases (2dMCOs) with similarity to McoN from Nitrosomonas europaea. 2dMCO is a trimeric type C blue copper oxidase. Each subunit houses a type 1 copper site in domain 1 and a type 2/type 3 trinuclear copper cluster at the subunit-subunit interface. The 2dMCO is proposed to be a key intermediate in the evolution of three domain MCOs. Multicopper oxidases couple oxidation of substrates with reduction of dioxygen to water. These MCOs are capable of oxidizing a vast range of substrates, varying from aromatic to inorganic compounds such as metals.	2.00611e-53
CP034437.1\|AZN39399.1\|1499735_1500023_+\|small,-acid-soluble-spore-protein,-alpha/beta-type	gnl\|CDD\|365990	pfam00269, SASP, Small, acid-soluble spore proteins, alpha/beta type.	9.05201e-14
CP034437.1\|AZN39407.1\|1511000_1512509_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	0
CP034437.1\|AZN39406.1\|1506885_1508757_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	4.99176e-163
CP034437.1\|AZN39413.1\|1517787_1518735_+\|hypothetical-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	7.43785e-27
CP034437.1\|AZN39401.1\|1500880_1502386_+\|HAMP-domain-containing-protein	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	6.73038e-49
CP034437.1\|AZN39402.1\|1502491_1503319_+\|hypothetical-protein	gnl\|CDD\|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	0.00869021
CP034437.1\|AZN43569.1\|1503975_1504851_-\|bifunctional-5,10-methylenetetrahydrofolate-dehydrogenase/5,10-methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|223268	COG0190, FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism].	9.18779e-107
CP034437.1\|AZN39408.1\|1513671_1514661_+\|RNA-methyltransferase	gnl\|CDD\|223971	COG1041, COG1041, Predicted DNA modification methylase [DNA replication, recombination, and repair].	3.58442e-20
CP034437.1\|AZN39411.1\|1516916_1517237_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.18129e-21

>CP034437.1|AZN43570.1|1508789_1510301_+|glycerol-kinase
MEKGEYILALDEGTTSCRAILFDRQGRAAASAQREFASVFPQAGWVEQDADEIWRTQLAVMREAASSVSAAQISAIGITNQRETLVVWDAETGEPLHQAIVWQCRRTSAMCESLKAEGWEAEVRARTGLVLDPYFTGTKLKWLLDEVPGLREKAEAGRVLVGTIDTWLIWKLTEGAVHATDVSNASRTMLFNIHTLAWDEEILARLGIPAVMLPEVKPSSGIFGYTRLLDGDGEGTATEMTPPAGIPIAGVAGDQQAALFGQGCFESGMAKNTYGTGCFLLTNTGESPIASEKGLLTTIAWQMDGKTTYALEGSVFTAGSVIQWLRDGLGLIAHASESEALAASVADTLGVYVVPAFTGLGTPYWNADARGMITGLTRGATSAHLVRAALESIAYQTADVLGTMAAESGLRLKELRVDGGAVANSLLMQFQADLLGVSVIRPVMLETTALGAAFLAGLGVGFWSGTDELRALWELDRTFVPERDEAWRAGVYGGWQKAVGYQL
>CP034437.1|AZN39406.1|1506885_1508757_+|glycerol-3-phosphate-dehydrogenase/oxidase
MNEPFSASARTMYLERMASELLDVLIIGGGITGAGIAWDASRRGLQAGLVEMGDYAQGTSSRSTKLVHGGLRYLKQGEVRLVAEVGRERALLHKHAPHVVIPAPMLMPVYKGGTFGYFASSIGLYIYDRLARVKHAERRRMYRREQTEALEPLLKTEGLRGSGHYYEYRTDDARLTLEVMKTAHRHGASIVNYAKAEEMLYRDGVICGARVKDTRSGKSYDIYARKIVNAAGPWADHVRSMDGKVEGKRLMLTKGVHLVVDYAKLPVKQAIYIDVHDGRMIFIIPRDGKTYFGTTDTFYQDDPGDVIATRADRDYLLTAVNAAFPTAALTSADIESSWAGVRPLIHEDGKSPSEISRKDEIFVSDKGLITIAGGKLTGFRKMAEKVVDLVAAEIREGTGRKFGGCTTHEEVLSGGDYSGYPTFEAMCEALLLEGERQGVPEEAMSGWVTRYGSNTPKLLARYTEYERAEAKEQRAAASAGAGLPVAAAREDAGADGARDAGGTGGVGGADGTGGSGSGSAAGAGRRITVAVGRAEALNHARQEWALRAELDYAVEEEMICSAVDFLLRRTGMILFDRRRAEKLTGAVVRLLGQRFGWNEEKRRTELTRVQAELHAAAAFPAMT
>CP034437.1|AZN39405.1|1506297_1506690_-|glyoxalase
MTTSKSFSFGGIDHIQLAAPPGCEEAARHFYAGVLGWSELAKPVELQKRGGVWFQCGSHQVHIGVQQHFVPALKAHPAFLVNQLDALRSYLTEAGINVIDDDARSAESIRRFYVSDPFGNRLEFMEYIAL
>CP034437.1|AZN39404.1|1505061_1506228_-|copper-amine-oxidase-N-terminal-domain-containing-protein
MKLNSFLKRSTAAMMIAGALTVSFAAAPPTGLATAKAESAIAPQQTKPIFVYFNSTQLSSSDATAIMKDGNLMLPLSLLGGIPGATFSFDTASQTIHASYDTHKGSLLLGEQSGTVDGQSMTFAGKAILLNKRIYVPAHFVVAAIGGTLIWDAKYRTASLFASQYVTANGKGGEYRLDGTTGALYFKVKGQSQKLIGKSIAKLNLGYIPMATMSVISIGKDSELITISHVHGEPLINDEEYTLFVKKGVIIHQMQAHYWQFSPRNIATAGDLAVMTDNRTVQLVNGDGLIVKSYSLPELAGLDANFDIEAVHSDYLLFRSTEGLLYIADFKSGKTTALYQALKLETKQLAPFYDGITFKEQDGNKLYFEITSNQDGHREILSYGIGGA
>CP034437.1|AZN43569.1|1503975_1504851_-|bifunctional-5,10-methylenetetrahydrofolate-dehydrogenase/5,10-methenyltetrahydrofolate-cyclohydrolase
MARLLKAKEAADLVYAGIRERVSEHQRNGVQPRLATLLIEGDPASAYYAKSKQRMAEKLGIAFDLHDLPADISADELIRLIHSLNTDARIHGMMLELPLPKHLSATNIAARISPLKDIDGVTPANKLATLTGEAGLYPATPQACIELLRHYGYPLEGRNVTLIGRGQTVGLPLFHLLQREQATVTVCHSRTPDIASHLRYADIAIVAAGRPGIINREMVQPNPKLIVIDAGINETADGSIIGDAAADVCEAATAVSPVPGGVGTLTTAVLFRNLMDAIQLQHQATREENNQ
>CP034437.1|AZN39403.1|1503346_1503979_-|methenyltetrahydrofolate-cyclohydrolase
MTTVSWDDSLRSFLERAASADPTPGGGSAAAVAAALGTAMSAMASHLTQGDKFAEAQHLIAPALDQLARLSAECEELLAADIRAFDHYMAALKLPRATTDEKLLRKSILHDATISAIEVPLRLMRVCRSGLQSTHSIAACTNPHVISDLGIGAILLEAAAQSALLTVQINLSALGNDNEQRSELEIEANALITDIGQIKNRTLAVVRDRI
>CP034437.1|AZN39402.1|1502491_1503319_+|hypothetical-protein
MSVSIDRARQFVYANGLLWEQALFSYLFDGGSIERLHSCLLNYKNADGGWGHGLEHDIKCPDSHPLALEFLLNINRDTGVPITPLLEGTVEWVERNREADGSLRDPESLMKYPLAPWWSGGGQSKPDSITGNLIRLGICSDELKASTAQWASDHLNVTQIEENEWLFMAYHAFDYYVNTPATPEHAQHREAAIANIVACASKAEPKQYSSYFSFAAAPDSPVAQATPPELVNKFLDHLASSQREDGGWDDEHGLKHWQAYMTTVVLNTLRNYGRL
>CP034437.1|AZN39401.1|1500880_1502386_+|HAMP-domain-containing-protein
MIRRKGIRFKIFLVTTALLVTFALVIYLTLYFMLPSYYKTIKQDRLESGVSELVKAINGKSTTDAIPLMAQFGQEHNAMMMLRDSTGNGYYIPPNFRAMKNWIGTGDSYLGFRKQMQAGRFEAGSRDPGDRGMHLLSVERKIKFAESDEVFTLFVDAPLQPIGEAASVILLFLPYMLIPILLIAIGGALIYARLIARPLISLNKVARRLAKLDFSATEPALKTRDELGELSLSLSRLAVNLQSTMGELQEANTQLKSDIEREREQETKRREFVATISHELKTPITAVSGQLEAMIANVGAFRDRDTYLRKSYTIMQDMDKLVHEILELSKLESRDFLPLMREVDLVDLIRESVGHVSYLANVKNMILDCELPDEALITADERLMSKAVSNIITNAVQYSGDEERVIVRLWEEPESVSTDGDESRKMYRFEVLNTGVTIEESKLPRLFEPFYRAEQSRSRSTGGSGLGLYIVSKVLDAHGAQYAITNTPEGVRFSVLLQGAA
>CP034437.1|AZN39400.1|1500200_1500884_+|response-regulator-transcription-factor
MPAAILVVEDDYYIQELIAEFLRAQNYEVDVASDGLEGWGKFQQSHYDLVILDLMLPSMNGYEVCRLIRERSDTPVIVLTALSEEKDQLKAFEEEADDYVTKPFSFHVLMKRVEAVLRRTRVGQSGELLFDGRLRLDADAYKVYVDGKMIDTTTKEFDILNTLILNAGRILTRDMLLDKVWGYDYYGDSRIVDAHIKNIRKKLGISVIRTVKGVGYSLETEVTAVEG
>CP034437.1|AZN39399.1|1499735_1500023_+|small,-acid-soluble-spore-protein,-alpha/beta-type
MARRSRRKHVVPAADAQMSAFKAEVMRREGYVVNPSRPDDVKYEVAKSLGIPLEHGYNGQLSTESAGQIGGQIGGAMVKELIRMAQEKLANEGRQ
>CP034437.1|AZN39407.1|1511000_1512509_-|alpha-N-arabinofuranosidase
MQAKLIVDKDFTIGEVDKRIYGSFIEHLGRAVYGGIYEPGHPSADEQGFRGDVMELIRGIDVPIVRYPGGNFVSGYNWEDGVGPVELRPRRLELAWRTVEPNLFGLGEFVDWCRKAGTAPMMAVNLGTRGPEEARQLVEYSNHPSGTYWSDLRVQHGYKAPHAIKTWCLGNEMDGPWQIGAKTAEEYGRIAAETAKVMKWVDPSIELVACGSSALGMPTFPEWERTVLDLSYNEVDYISLHQYYGNRDKDSANFLAQSMGMDAFIGSVIATCDYIQAKKRSKKKLHLSFDEWNVWYHSNEADSRIEPWSVAPPQLEDVYNHEDALLVGSMLISMLKRADRVKMACMAQLVNVIAPIMTETGGGAWKQTIYYPYMHTSIFGRGTVLVPLVESPKYDAKDYTDVPYLDAIAVHNAEAGEVTVFAVNRHLSESLPLSVDLRSFGSFRLIEHIVLESDDLKAANTKAAPDRVAPHTRGNAVVESSGSGLAASLGKASWNVIRVKLG
>CP034437.1|AZN43571.1|1512754_1513651_+|ArsR-family-transcriptional-regulator
MAPLYEALASDVRLHILELLAVQPMNIKELAAALGLSSAIVTMHAKKLEKGGLIETKLVRRSGGTHKICSLAEGQVEITIPQTAEQKRECHEVSVPVGHYTSFDIHPTCGLATSEHMIGQFDDPRYFHDPQRMHAQILWFGKGYVEYRIPNYVLLGQSLEEIEISFEIGSEAPGVRADWPSDIHFFLNNTQLGMWTSPGDSGEGQGKLNPAWWSVKLNQYGWLKIIRITKDGTYLDGQRMSDVKLDDIVMSRNDWQLRLAVPEEAEHVGGLTIYGEAFGNYNQSIVFRTYRAASGSHE
>CP034437.1|AZN39408.1|1513671_1514661_+|RNA-methyltransferase
MIDFVQNIPINETCFYAVSCHEDEQDLCGLEMRSLFNCDPQQGCVISDKNIDPSRSPFIRGKLAIQLIADDAAGIAAQVGEAVALEGRTFKVSFVGSDVPVDFDRQRAIEKEIGWQIVGQAEMRQPDRLFGVAIVDGRYLFGEFEKSEALWLKHNEKPQPYSTALSTRVARAVVNIAAPVITAELRVIDPCCGIGTVLIEALSMGIDIVGYDLNPLALRGARVNLAHFGMPDVVRKADMTQLQLQEPSASGAQPYDAAIIDLPYNLCSVLPSEERLAMLQSARRLAARVVIVTTETIDEDIAAARLAITDRCVVRKGKFERQVIVCRHA
>CP034437.1|AZN39409.1|1514758_1515763_-|aldo/keto-reductase
MVEQTDTTGVNTQLRRRLGNSDLELSPLGLGCWQFSKGSGMVGKFWPVLADEDILGIVRTSLEGGINWFDTAEVYGGGKSEEALADALNSLGNAASGAHVATKWWPIMRTAGSIPRTIDERLRRLKGWPIDLHQVHQPYSFSSAAAEMNEMAKLVQQGKIRHVGVSNFSAARMREADKALRAHGLRLTSNQVKYNLLDRRIEHNGVLDTAKELGVAIIAYSPLEQGVLTGKFHSNPELVRGIAAGRKLSGSFKPAALARTRPLVDRLAELAGKYGASPSQVALNWLIHANGDTVFAIPGASKPRHAQENVHAMAFKLSSDELQELAVLADRCKR
>CP034437.1|AZN39410.1|1515847_1516714_-|aldose-epimerase
MSYEVKRTVDTYELFTLIDTETNSSVTVCPQRGGIAISCILGGVELFYLDKATLIDPVANIRGGNPILFPICGQLVEGRYEWEGTEYTMRNHGVARNRPWEVVETNEDGEASITLRLRSDASTRDEFPWDFELLFTYALVSGELKIRQTYSNLSGSAMPYYAGFHPYFRCESKDIVYGTDASQYLDYNDNVIKDVQGEIVLTGLKESVALLDATERHISFPGPDNSGKITLNYSDAFKYVVLWQVNGSPFVCVEPWMALNSELNRKAELPMLAAGAKQELELSIAFEK
>CP034437.1|AZN39411.1|1516916_1517237_+|PadR-family-transcriptional-regulator
MNVQFKKGVLDLCVLALTAWEDRYGYELAVSMSSKFEVAVGSVYPLLSRLTQEGYFSTYLRESSEGPPRKYYKLTPEGHRHLLELIREWKSFSVAVDEIIKEGVER
>CP034437.1|AZN39412.1|1517233_1517791_+|DUF1700-domain-containing-protein
MIRNQYLEQLWELLAPVPERIRREWMYDYEEHFRMAAEHGKSEVEAAHELGDPRLIAKELLLTYRVDQAETKSGSVTLVSRAVLAAVSLGFFNLIFVLGPYVALLGVLVALWASAIGVGVSSLMALYEGMYGGGVTMTQGIFIAMVLLGLGMLLGAGTQWLTKAFMKMTLAYLKFNSRVIRVKKK
>CP034437.1|AZN39413.1|1517787_1518735_+|hypothetical-protein
MRNWVVIALILVVVGLIGAFGTSRGDFSFGTEKIDQQQWMEGDGVSEIVVKSGSMDVTVIPSSDQKIKAKLSGRASRKYRDKLKLTLERNGDQLNVTLEDKVGFTIGLNFRSVDLTLELPQQMYRKLVVDTGSGDAELKQVQADRIELDMGSGDVSLQELTAQAMIVDIGSGDMHATAITANESVELKANSGDVTVDGLKSKQLTVRTGSGNIELNDVDAAIKGEAHSGDIDLALDALNRAVDLETGSGDVSIMTSEQPQNAHITYSSGSGDLDNDWDGVKKMTDEDGRDNLVFGSGSIPVHVHTGSGDLDVGAR
>CP034437.1|AZN39414.1|1518915_1519806_+|copper-oxidase
MVESPDLPLAPYRIENGMKCFELIAEPVLQELLPDIYMQGYGYNGSIPGPTIVVETGDWVRIRVINHLPEATSVHWHGLDVPNTMDGVPPIEPSPRIEPGYGMDYIFQIINPPGTHMYHSHYHTLRQEMLGLCGLFIIQNKQEKHIHRDIAYMLQEFHLSGLPRGELRPGAYSIDPLSDGFNFFTMNGRCFPSTSPVQVRLGERMRIRLANIGMQGHPMHLHGVQMLETAYDGNEVPPWRQLLRSTVFVAPGETRDVQFVAWNPGFWPFHCHIPHHTSNNFTIPIGGMFTTIQVAR
>CP034437.1|AZN39415.1|1519837_1521292_+|HD-GYP-domain-containing-protein
MQLKGKSVIGPILSVVLPIGVFEWVRSLGTKDVSLVVPAGHFHIVTIVAALAMLVAIGVGITGHRLRNIQVGFMSIAYLSLSGVFFLHGLTTPGFLMHEDYMPKIFAQLSVLLTAVWLALSAVSSDHWSVRLMSKWRILLLPGWLVLLGVLCALTIRYPDAIDHLPLTINPYKWIAGAATGAACLWTMYRYWHANQHGRIPLQQAIVYSTGLIVASQYIILMGSAWKLSWWLYHFLLLGSLLTMLLGLVRQYFSKGSFSTSLRILFQSDPRAWLEEWITPSVHALIMATEARDSYTAGHNKRVALYALRLGEVMGLTKHQLQAIAHGGVVHDVGKLRVPDSILNKRGKLTTEERLVIERHPVSGYEICRQLGFLRDELSIIRSHHEKWDGTGYPDRLSGEGIPLLARITAVADVYDALTSSRSYRLAMSHEDAMEIILSGSGVHFDPMCVMAWEKLASIDAQFFAEIAASDRTLHLAHSHKAAQ

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Crispr_ID: CP034437_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_4

1557785-1557861

Orphan

Consensus_repeat	Method
AAAGAGAATCCCCCAGGGATCTACAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP034437_4

>merge|CP034437|4|1557785-1557861|CRISPRCasFinder
AAAGAGAATCCCCCAGGGATCTACATTAGCGGAAAACCGGCAATTCGGCCCAAAGAGAATCCCCCAGGGATCTACAT

>CP034437|4|1|1557785-1557861|CRISPRCasFinder
AAAGAGAATCCCCCAGGGATCTACAT	TAGCGGAAAACCGGCAATTCGGCCC
AAAGAGAATCCCCCAGGGATCTACAT

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN39446.1\|1549008_1550037_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
CP034437.1\|AZN43573.1\|1553751_1556115_+\|3-hydroxyacyl-CoA-dehydrogenase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|224170
CP034437.1\|AZN39451.1\|1561454_1561892_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
CP034437.1\|AZN39454.1\|1562794_1563538_+\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
CP034437.1\|AZN39441.1\|1546256_1546640_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
CP034437.1\|AZN39442.1\|1546630_1547050_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|235142
CP034437.1\|AZN39455.1\|1563521_1564520_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
CP034437.1\|AZN39443.1\|1547140_1547953_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|369566
CP034437.1\|AZN43572.1\|1551215_1553516_+\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
CP034437.1\|AZN39458.1\|1566611_1567655_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
CP034437.1\|AZN39456.1\|1564591_1565293_+\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837
CP034437.1\|AZN39445.1\|1548458_1548716_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39448.1\|1556195_1557404_+\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|181072
CP034437.1\|AZN39444.1\|1547952_1548420_+\|DUF664-domain-containing-protein	unknown	unknown	gnl\|CDD\|225200
CP034437.1\|AZN39447.1\|1550054_1550903_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
CP034437.1\|AZN39457.1\|1565694_1566483_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN39452.1\|1562005_1562230_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39453.1\|1562515_1562704_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39450.1\|1559761_1561492_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|180666
CP034437.1\|AZN39449.1\|1557949_1559743_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173850

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN39446.1\|1549008_1550037_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	5.89541e-116
CP034437.1\|AZN43573.1\|1553751_1556115_+\|3-hydroxyacyl-CoA-dehydrogenase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	2.53828e-64
CP034437.1\|AZN39451.1\|1561454_1561892_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	5.64672e-31
CP034437.1\|AZN39454.1\|1562794_1563538_+\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	3.18685e-126
CP034437.1\|AZN39442.1\|1546630_1547050_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|235142	PRK03624, PRK03624, putative acetyltransferase; Provisional.	9.02303e-26
CP034437.1\|AZN39441.1\|1546256_1546640_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	8.73536e-19
CP034437.1\|AZN39455.1\|1563521_1564520_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.97204e-27
CP034437.1\|AZN39450.1\|1559761_1561492_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|180666	PRK06710, PRK06710, long-chain-fatty-acid--CoA ligase; Validated.	0
CP034437.1\|AZN39443.1\|1547140_1547953_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|369566	pfam07876, Dabb, Stress responsive A/B Barrel Domain. The function of this family is unknown, but it is upregulated in response to salt stress in Populus balsamifera. It is also found at the C-terminus of an fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus. Arthrobacter nicotinovorans ORF106 is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved and the domain forms an a/b barrel dimer. Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	6.5935e-20
CP034437.1\|AZN39458.1\|1566611_1567655_+\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	1.86191e-178
CP034437.1\|AZN39456.1\|1564591_1565293_+\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	1.87472e-41
CP034437.1\|AZN39444.1\|1547952_1548420_+\|DUF664-domain-containing-protein	gnl\|CDD\|225200	COG2318, DinB, Uncharacterized protein conserved in bacteria [Function unknown].	2.43009e-21
CP034437.1\|AZN39448.1\|1556195_1557404_+\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|181072	PRK07661, PRK07661, acetyl-CoA C-acetyltransferase.	0
CP034437.1\|AZN39447.1\|1550054_1550903_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	3.6828e-82
CP034437.1\|AZN39457.1\|1565694_1566483_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	5.34338e-24
CP034437.1\|AZN43572.1\|1551215_1553516_+\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	4.97226e-72
CP034437.1\|AZN39449.1\|1557949_1559743_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173850	cd01161, VLCAD, Very long chain acyl-CoA dehydrogenase. VLCAD is an acyl-CoA dehydrogenase (ACAD), which is found in the mitochondria of eukaryotes and in some bacteria. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. VLCAD acts as a homodimer.	1.73413e-172

>CP034437.1|AZN39448.1|1556195_1557404_+|acetyl-CoA-C-acyltransferase
MTKANQNHPLDAVIVSAVRTAVGKAKKGSLADTRAEDLGRAVLRAAVDRVPGLAYGDVQDVVIGCAMPEGEQGLNFARIMTLYAGFPVTTPAVTVNRFCASGLQAIAYAAERIRLGEAEVVLAGGVESMSHVPMTGFKLSPHPGIADAMPEVYMGMGHTAEEVARRYGISREAQDAFAAASHAKAAAAQAAGRFSEEIVPLHVQREGVDDNGRPWSRSFVFDSDEGVRADTTPEVLVKLKPSFAREGTVTAGNASQMSDGAAAVVIMSRERAEQLGVKPLAVFRAYSVAGVAPEVMGIGPIEAIPKALARASVGLEQVKLFELNEAFAAQCLPIVQRLGINPELVNVNGGAIALGHPLGCTGTKLSVSLIHELQRRGGGFGMVSMCVGGGMGAAGVFEVPPA
>CP034437.1|AZN43573.1|1553751_1556115_+|3-hydroxyacyl-CoA-dehydrogenase/enoyl-CoA-hydratase-family-protein
MGAGIAAHLSNAGISVLLLDIPPTSLTEQEERAGRTLQDAAVRNRLAAASIARLVNQQPAALYDAAFARRITAGNLEDDLGKLAGVEWIVEAVVERLDVKQAVFERIEPWLGPETLVTTNTSGLSASAMAEGRGEKFRKHFAVTHFFNPPRHMKLVELVAGPDTEPTVMARLAAICERQLGKGVVTAKDTPNFIANRIGTYGMMTTFAAMKQFGLNVDEVDALTGPAMGRPKTATFRMLDLVGLDTLLHVVDNVRERSEDSEDQEAFARPPELEALVARGWIGEKAGSGFYRKIKRPGGGSDIETLQLDTMEYAPRRSVNSPVIEAAKSAKGAAGKLKALLFTDPNDRYAKFGWQVTKTMLLYSARQLGVVADTIDDIDKALVWGFNWELGPFELWDAIGLEKSVQRMRAEGDDIPGWLSEWLASGNKSFYKEEGQRRFYVDRGEFRQVEEKPDVISLAALKRAGRTILGNSGASLLDLGDEVACLVFHSPNNAIGGDILSAIRQSADEVSRNWRGLVIANEGRHFCVGANLMMLLMEAQNGDFDEVDDIIRLFQNSMLTLKRLDRPVVAAPHRMTLGGGVEACLPADRIIFSAETYFGLVETGVGLIPAGGGCKEAAVMASARAGATGDLQPHVNALFETIAMAKTSSSGYDVHRTGLMRPGDRVIMRDETRVAEAKRSVLELDQAGYEAPGSANARVRVAGREGRAVLQLGVEAMRLSGQISEHDVKIGRKLAHVIAGGDAAPGAEVSEQYLLDLEREAFLSLCGEPLTQARMRHMLTTGKPLRN
>CP034437.1|AZN43572.1|1551215_1553516_+|(Fe-S)-binding-protein
MTAGALVCFYLVVSRRVGYIRLGRRIAPKRPAPPYDEAGDEYDDRESESEDTVRLSSFSANAALASEAVASPEARRRLEWAYQVFGHRKLLKDIRSGLMHLVLFYGFIVLQFGALDIIWEGISGSPLPFLDYHWFVYMQEMTVSLVLLALLYGGFRRYVERLRRLKRGWKPSIVLWFIGGLMITVLLTQAFNRLQGASSGSASLYVGYAPVSSAIAEALRLVDVTHDVSRVFYELFWWLHYAVLLSFLVYVPQSKHFHIFTAPVNLWLRRRSPPGKLTPLDLEDETAESFGVGAIEEFTQKQLLDLYACVECGRCTNVCPASNTGKLLSPMHLIVKLRDHLTEKGAAITSKSPWVPAFGGGAGLPSSAHVMQSDAPVLWVKQSESEGTAVTIDPTMTAQKQAWTVHADMAPSDVALIGDVMTESELWSCTTCRNCEDQCPVGNEHVDKIIDMRRFLVLTEGKIPAEAQRAMNNIERQGNPWGLPRSERGSWLSAYNSAFAVEGAAPVLTMQEAAKRKGSEERPELVLWAGTMGAYDQRSRKVLFAVVRLLQHAGIPFAVLGGEERNSGDTARRLGNELLFQTLCTENIATLERYGVRRVVTICPHTFNAFKNEYPDFGLSKSVVVEHHTSLLERLVAQQLIKPVHPLGERVVFHDSCYLGRYNGIYDAPRNLLRAIPGVKLLEMERNRDNGMCCGAGGGLMWMEERSGVRVNEARASQAIATSPTIIGSACPYCLTMMEDGIKLLDAEDTVRARDVAELLAESVFG
>CP034437.1|AZN39447.1|1550054_1550903_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MQLVVLMKQTFDTEEKIEIVNGTADEQNVKFIINPYDEYALEEALRLREAHGGTVTVVSCGSDRAIEALRTALAMGADEAVLLSAESLQGDDGFAVASALAKVVEQLKPDLLLAGLFAVDRGAGSVALQIAERLGLPQAAAALKVEVKDADGGNANAAGNSLSPSGASWSGGGVKQVAVVERDTEWGVETVEVPLPALITAQQGLNEPRYPSLPGIMKAKKKPLKQISASELGLAADDLAPRTKRVALLAPPVRAAGRKLGGTPQEQAAQLADLLQREAKLF
>CP034437.1|AZN39446.1|1549008_1550037_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSDTEKRTALVYAECAEGALRRVALEALGAARRLAGDGGSVHAVVVGGGASAAALGTAAAELAARGAEVVHVVDDPALAGFAPEAYAAAIGAAIAAVQPSIIVLGHTAAGRELAPRVAAAVNGGHIADVTAVDVDDDGGAAAIFTRPLYAGKAFEQRRFLPGAPQVITVRPNNLPVAEPVAPGSEGTIAALAYSAPPLWTIVRDVVRKASGRIDLAEADIIVSGGRGVRSAEGFAPLEELAAVVGGAVGASRGACDAGYCDYSLQIGQTGKTVTPKLYIACGISGAIQHLAGMSQSRVIVAINKDPDAPIFGVADYGIVGDLFDVVPLLTEQFRAILQKPGP
>CP034437.1|AZN39445.1|1548458_1548716_+|hypothetical-protein
MTLRQFARGLTGALVVPWFIYFALHLYVEYRNQAPDDFAYHDSYFLALNVGWIGYFTLVVVLLAVYSIAVASFNWIGKRRKPGRR
>CP034437.1|AZN39444.1|1547952_1548420_+|DUF664-domain-containing-protein
MVKALFQYNWLVRDEWFRLLETVPEKELAKKQLAGVGSFLDTMLHIIDVEYSWFRTIVKKPDIQFDPAEYGSLAAIKALSDKLRPEIEAVLDGWSHEQDGELVSPSWQEQQFYRKDEIWHHMIVHEIHHIGQFSVWAKELGVKSASANFIGRGLL
>CP034437.1|AZN39443.1|1547140_1547953_+|GNAT-family-N-acetyltransferase
MRGWPMLRIDICRVERLEDYDLTSLLTESEAEGFRHIRRFVNEYLDGSNRFDLEGEVLFLARVNGLVAGVGGLNREMSDKTRRAAGRVRRVYVASAYRRQGVARALMKAILEHAENGSSFAYDRLVLRCGSSEADLFYRSLGFQTVEGNASITHELLFNLTSEEEQLMDNKSIQHMVIFDLKHSAGSAEAEQFLKDGQRLLTSIPVVRSFQVFNQVSAKNDYQYGFSMVFDNQADYEAYNAHPVHVDFVEGRWVPEVARFLEIDFKNYGG
>CP034437.1|AZN39442.1|1546630_1547050_+|GNAT-family-N-acetyltransferase
MELIYREMTIDDYEAAYTLWMKTEGMVLSGADSEEEIDAYLARNPGASFVCEADGELVGTILGGHDGRRGFIYHVAVSTDTRGRGIGQRLVQLSLGKLSEAGIAKCHLFVLEDNPIGSRFWARTGWQKREGILLFSKDT
>CP034437.1|AZN39441.1|1546256_1546640_+|histidine-phosphatase-family-protein
MADTRGLPVVCYEELRERRLHGPEYPLAGEEFLGVIQRSFEDKRFALPGGESFEEVQQRALPVIKQLLCEHQGKTVVVGTHGNIMAMLLNAFDERYDYEFWRSVEMPDVYEVEFDGEQLVEVRRLWS
>CP034437.1|AZN39449.1|1557949_1559743_+|acyl-CoA-dehydrogenase
MAQNNRWGGRFVVEDITPDAIVTPEDFTDEQRMIADAARAFLAGEVRPRDAEIEALNYELTTQLLRKAGDLGLLGADVPEAYGGLGLDKVSSTLLAETFSEASSFALSIGAHVGIGTLPIVFFGTPEQKQRYLPDLATAKRIAAYCLTEPASGSDALGARTTARLSPDGKHYILNGSKLYITNSGFADVFIVYAKVNGDHFTAFIVERGYPGFSIGPEEHKMGIKGSSTCPIFFEDTPVPVENVLGEIGKGHLIAFNILNIGRFKLAAGCVGGAKETIGLSSKYANQRKQFGRSISSFPLIGAKLADMNIATYVLESMVYRTAGWIDALLQESEAEGGTDENAGARAAKAISEYALECSINKVFATEVLDHVADEGVQIHGGYGYIREYKVERIYRDSRINRIFEGTNEINRMLIPGTLMKKALKGELPLLRKARALQAELLQPMPLPSFDEPLSKETYRVQQAKKIFLAVGGLAVQKYGLALEQQQEVLCLLADMMIQVFAMESASLRTRKMLQKADPAAAARIKNATEMTVVFVQEAMERVERYAKTALSALEEGDSLQTQLSVLKKLTRAPLSDTIALKRGIAARVIRSEQYTL
>CP034437.1|AZN39450.1|1559761_1561492_+|long-chain-fatty-acid--CoA-ligase
MDQAQASPWFRNYPGEVPNTLDIPNISISDLLLQTAAKFPSNEALHFYGKRTTYRELLAAANRMAAGLQAVGIGKGDRVAIMLPNCPQTVIAYYGVLLAGAVAVMTNPLYVERELTHQLKDSGARCIITLDLLYPRLARVRGEAPEEGPVPQLRTVLITSIQDELPFPKNMLYPIKQRRAGHNPSIPYGKHGVTRYTSFLSKAPKLPAEAAVNPESDTAQLQYTGGTTGLAKGVILTHRNLVANVLQCSAWFYRVDEGKERFLAALPLFHVFGLTSLMNLSILKAGSLILLPRFEVLTVLQTIRKLKPTVFPGAPTMYIALLNHPDVKKYDLSSIKVCVSGSSPLPLEVQTKFEALTGGRLIEGYGLTEASPVTHVNPIWTKRRIGSIGLPLPNTEARIADMETGEDVPEGEIGELLVRGPQVMKGYWNNEAATEASFRGEWLRTGDLAQVDRDGFFAIVDRIKDIIIASGFNVYPREIEEVLYEHPGVRDACVIGVKDEYRGETVKAYVVLRKDVHVSAMQLDRWCRDRLAVFKVPHLYEFRTELPMSMIGKVLRRKLQEEETNEREGTGGPPSP
>CP034437.1|AZN39451.1|1561454_1561892_+|PaaI-family-thioesterase
MNEKEQEVPRPRDELSRLNQLAEAAKPTFWGYLGCELVHASPGKCGISLQVRPEHLNLAHIVHGGVLASLLDNAMGLVVILECPGEKTVTTQLNVHYLQSAGQGEIRCEAVLIHKSRRTLTLQGSIVDNNGELLAWGSGTFRRVT
>CP034437.1|AZN39452.1|1562005_1562230_+|hypothetical-protein
MVSPWVTGAVILFGIIVAVTGVIAYLRVYKNSSWSAMTSRSPESAPPRTVILERKQREESAAAEVEEASEQGES
>CP034437.1|AZN39453.1|1562515_1562704_+|hypothetical-protein
MAKRSHNEVKESLVELTRIFQPKDSRKFVREYIRKYRIMGGYEEELTLLVEHEMGRLRSSVS
>CP034437.1|AZN39454.1|1562794_1563538_+|type-I-methionyl-aminopeptidase
MIHYKTDEQLRLIRKAGRIVAACHKEIAARIKPGVSTLEINRFADAYMRRYGARPAQIGYKGYPYATCASVCDAVCHGFPTAVPLKEGQIVTIDMVAELDGWMADSAWTYAVGRVSPEIQKLMKLTKQALYRGIAQAVDGKRLGDIGFAVQQIADREGYSVVEEFIGHGIGRRMHEDPQVLHRGKPGTGKWLRKGMVITIEPIFVMGGPHVNIGSDGWTVRTVDGSWGAQFEHTVAVMDGEPIILTR
>CP034437.1|AZN39455.1|1563521_1564520_-|AraC-family-transcriptional-regulator
MPSTPRLPGMPNATKAPQNSPSSMPGFSKGERLLPFSSLFEDDKEAPIYVNRAHETFELLKHAHDFIEVCIVAEGTGFHYIGDEQMPVARGDLFFIPVGVSHVFRPGSTARSRQLIIYNCTFTMEQLDRLLHAVPAESAIAAMYRQLCDGRQWLHVHERGEEGQLLFHKLYQEFTTRRPGYAASMCAAVIELLIMLYRRQLEREAMPEQQQTKQAAPPSSMQQVIEAIDADCAASNLSVAAMAAQLGISERQFQRSFQKATGMTFLAYVQSARIDLSCKLLLSTDDLVSRIALRAGYQDVKFFSRLFKKKTGMTPREFRSTQRPEPLITLSE
>CP034437.1|AZN39456.1|1564591_1565293_+|SOS-response-associated-peptidase
MFSVHPGNNSQNNWRCFPMCEAIAITAQSSELTDKFELDNILLYIANRNEVTPTDTISAIFEHKETGRILDEFRWGMVPYWAKDSVHMDRSQLFHKPIYERIVQKQRCIIPCNGFYVTRTIGKEVHRLKLMMRSGTFAIAGLYDVFRQASGFEMRTCTMMMTEANELVSPYQPLMPAILEPEAIGDWLHRGNRPPYELHAMLCPMDELRMIAIPLGGTGDEEVELQAPRTEWV
>CP034437.1|AZN39457.1|1565694_1566483_-|AraC-family-transcriptional-regulator
MFHIFDIKQERGVLQEERRMLGIDSFTLIWIRFGQTSFTYAGQVVSCRKNELLLIPAGIPAAELRASGSIRESVTVRFSPADTATTQLLPILARRAPLRWVTHMPELLMEKLLVIVEQWTARDRYFSVMCAALLTELIVTISREYDEGEKAPSSIQHIERMKQYVENHYRGKITKNELGACIGVSPNYAATLFRKVTGLTISDYVHRKRMKTAHYMLRHSRLTVQDISEHLGYSDPSYFNRIFKKVIGRLPSDVIAERSQLE
>CP034437.1|AZN39458.1|1566611_1567655_+|pyruvate-kinase
MKKTAIVCTMGPACMAADKLEGMLKAGMNIARLNLAHGDLDDHRQRILIVREAARKLNVPVSILLDIKGPEIRTGLLQEPSYMLKSGEFLTLTTEQFVGNASRISVSYDLAQDVAVGSRIMIDDGLIELEVVRIEGTEVVCVILNGGIIKSRKGVNLPGIRTSLPGVTEKDKLHIAFGVETGVDIIAMSFVRRAEDVMEVKRMLAEQGASHIQVHSKIENQEGLDELAAIIEASDGIMVARGDLGVEIPIEEVPLAQKRMISACNRAGKFVITATQMLESMQSNPRPTRAEACDVANAVWDGTDAVMLSGETASGAYPVEAVQTMAAIAIKAEEALSEVVKKDLIEA

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Crispr_ID: CP034437_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_5

1814677-1814788

Orphan

Consensus_repeat	Method
TAGCTCAGTTGGTAGAGCAACTGACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP034437_5

>merge|CP034437|5|1814677-1814788|CRISPRCasFinder
TAGCTCAGTTGGTAGAGCAACTGACTTGTAATCAGTAGGTCGTGGGTTCGACTCCTATCGCCGGCACCATTTTTACATGAGCCATTAGCTCAGTTGGTAGAGCACCTGACTT

>CP034437|5|2|1814677-1814788|CRISPRCasFinder
TAGCTCAGTTGGTAGAGCAACTGACTT	GTAATCAGTAGGTCGTGGGTTCGACTCCTATCGCCGGCACCATTTTTACATGAGCCAT
TAGCTCAGTTGGTAGAGCACCTGACTT

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN39639.1\|1824560_1825709_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	unknown	unknown	gnl\|CDD\|239432
CP034437.1\|AZN39637.1\|1823141_1823759_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
CP034437.1\|AZN43590.1\|1821340_1821910_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
CP034437.1\|AZN39625.1\|1803763_1804993_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340831
CP034437.1\|AZN39622.1\|1801145_1801991_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|366542
CP034437.1\|AZN39632.1\|1815580_1817260_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270451
CP034437.1\|AZN39631.1\|1808045_1808828_+\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
CP034437.1\|AZN39636.1\|1822496_1823117_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39629.1\|1806474_1806861_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39630.1\|1806939_1807857_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187566
CP034437.1\|AZN43591.1\|1822002_1822479_+\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176903
CP034437.1\|AZN39627.1\|1805278_1805911_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370127
CP034437.1\|AZN39626.1\|1805012_1805195_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39638.1\|1823837_1824479_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
CP034437.1\|AZN39634.1\|1818236_1819052_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
CP034437.1\|AZN39624.1\|1803121_1803568_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP034437.1\|AZN39633.1\|1817259_1818222_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
CP034437.1\|AZN39635.1\|1819069_1821229_+\|alpha-L-rhamnosidase	unknown	unknown	gnl\|CDD\|379972
CP034437.1\|AZN39623.1\|1802006_1803017_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
CP034437.1\|AZN39628.1\|1806103_1806439_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN39637.1\|1823141_1823759_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.08001e-20
CP034437.1\|AZN43590.1\|1821340_1821910_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	1.20367e-116
CP034437.1\|AZN39624.1\|1803121_1803568_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.61062e-10
CP034437.1\|AZN39622.1\|1801145_1801991_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	4.43658e-33
CP034437.1\|AZN39632.1\|1815580_1817260_+\|extracellular-solute-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.90689e-28
CP034437.1\|AZN39631.1\|1808045_1808828_+\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	2.47486e-30
CP034437.1\|AZN39639.1\|1824560_1825709_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	gnl\|CDD\|239432	cd03316, MR_like, Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).	1.55682e-117
CP034437.1\|AZN39630.1\|1806939_1807857_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.14767e-115
CP034437.1\|AZN43591.1\|1822002_1822479_+\|polyketide-cyclase	gnl\|CDD\|176903	cd08894, SRPBCC_CalC_Aha1-like_1, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	6.0929e-66
CP034437.1\|AZN39627.1\|1805278_1805911_-\|hypothetical-protein	gnl\|CDD\|370127	pfam08795, DUF1796, Putative papain-like cysteine peptidase (DUF1796).	3.16441e-30
CP034437.1\|AZN39638.1\|1823837_1824479_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	4.45586e-39
CP034437.1\|AZN39634.1\|1818236_1819052_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.05108e-62
CP034437.1\|AZN39625.1\|1803763_1804993_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.73892e-60
CP034437.1\|AZN39633.1\|1817259_1818222_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.10123e-67
CP034437.1\|AZN39623.1\|1802006_1803017_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.35178e-56
CP034437.1\|AZN39635.1\|1819069_1821229_+\|alpha-L-rhamnosidase	gnl\|CDD\|379972	pfam17390, Bac_rhamnosid_C, Bacterial alpha-L-rhamnosidase C-terminal domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	1.01077e-13

>CP034437.1|AZN39631.1|1808045_1808828_+|phytanoyl-CoA-dioxygenase-family-protein
MTLEQLKQAKEQYDVNGYAVYPNVLDKELIQEAAEHVNWLMKQNPDLRPENLGNTLMTDDPFWVRLISDDRLLDIAEQYIGPDIALFASHYISKPPYDGRPVLWHQDGSYWPLEPMNVVTLWLAVDDSLPENGCLRVIPGTQTMELQEMKKNTKTANVLESEVDPALVEESKAVDLILPAGGVSVHHPNVIHGSEPNHSPLRRCGLTIRYIPTSTKITIPQWPSAFLLRGKAVPGVNDYLPFPKYVEGKHMPFRGCEDWA
>CP034437.1|AZN39630.1|1806939_1807857_-|NAD-dependent-epimerase/dehydratase-family-protein
MKAVVTGGAGFIGSHLVKGLLEGGAIVHVIDNLSSGIREHVAPGAVLHTEDVRSAEAKQIIASVKPEVVYHLAARADVQQSILAPAFDASVNITGTINILDACKTACVNKIIFASTSGVYGNLEKERITERDPAIPISFYGLSKLTAESYIHMYSQLYCLSYTILRYGNVYGPGQTAKGEGGVIANFMERTINNLPLYINGDGEQTRDFIYVRDVVRANLAAAHHADQETIHVSTGKSTSVNRIVELLRDMHTAEIDLHYRPAQSGDIKHSCLSNQKARTSLQWESAVSIEQGIAETYRSWLQSQ
>CP034437.1|AZN39629.1|1806474_1806861_+|hypothetical-protein
MKYSDKMVADSGGFVPFLVGPDEMVLASVALANIAQGDRIVLSLEIAWERLHDWDSGELEIMIREGTETGTVIYWNMESCFLRARSMERYTMAGGAAAAQRYYLIVRSAEKRARITGPYSLQGAVYAP
>CP034437.1|AZN39628.1|1806103_1806439_+|hypothetical-protein
MAIFQLAVAPGAKVDSRFVESVELTVMNESRRTFDILVQVSHNGAPFFESLQELPSGSGAYIPAVPTNYTPFNLLIVTNYFTYDTTTVTLIVRSKGLLLAIFTDKDFDRMP
>CP034437.1|AZN39627.1|1805278_1805911_-|hypothetical-protein
MRLAELKGTYDTIYSLGDLCLPAIQMELNDLRPFAGPLDWMQSQVLPDVIRLLANRFAGFMDYSHLEVISKATDKLYYVKEKEYNIYSNHDFYTHNNFPPELNAYPEVKAKYDRRVARFLEKAATSEQILFIRTEATPELTKQLTDVLSTLVAGSYRLLVVNHAPVAGIVEQDWGLPHVCAIQMPNEEVWQGNNHLWKQIFQLIKLKEEL
>CP034437.1|AZN39626.1|1805012_1805195_+|hypothetical-protein
MANQPFMVPADLYNRIFAAQTSDPSLKVDYEVWTLILAGLPEGYKLPDWTVLSTISKPTP
>CP034437.1|AZN39625.1|1803763_1804993_+|glycosyltransferase-family-1-protein
MRILLATYWAIPHVGGVWKYMLQLKERLEAMGHQVDMLGNSPDNTKIHMPGSNKELSKDVLRPLVMAKLNAARVPQVHSDHFVLHCEFERYYMELAAAYFGVAQYDLIHTQDIFAARAFERVRAPRTALVAHVHGSVALELTMNYKLNPQLGVKEGDPAWLYFNGLEHYGANAGHITVTANNWQKELLVQSFGVQANRISVFPYGLDIDAFTRKLKQGTTVSRPPGKKVIICPARLAFVKGIDVLIAALYRLKQRRQDWVCWIVGNGEKRDDLLRQTAELQLQQEVLFLGERDDIPGLLNNSDIFVHACIQDNQPFSVMEAQVAGLPALVSSAGGLPEMVQHGVNGLISPVRDTLTLATQLEMLLENDALRRQLGHNARQWAAKQWSMNTMMSNVIRVYQTAIAKSRIP
>CP034437.1|AZN39624.1|1803121_1803568_-|GNAT-family-N-acetyltransferase
MSLIVRNVEAADVTKVAELMHKYIVGFYNNPWPGDDSIDELIQTLLEKEEGIQFVVEKDGELVGFSTLYFSRSTMKAQKITVMNDFFVLEPYRNTKVESLLFMTCQKYTQDMGFSHMTWITSAENKRAQQFFDQAGAVQGNWMSYSIV
>CP034437.1|AZN39623.1|1802006_1803017_+|Gfo/Idh/MocA-family-oxidoreductase
MLKVGLIGFGFMGRMHFDQYTRLMKEGHPVQLVAVCDLRIEELKNGAAIGNIATNQELYDLSAFNLYTSIEEMLANEELDMVDITLPTTAHADLACQMLERGLHVLCEKPMARSAADSWKMVETAKRTGKQLMIAQCLRFWPAYEYLKACIEDGRYGQPLGGYFFRGSGLPQPWYLDGSLSGGVLMDMHIHDTDMINWLFGVPQKVSTIARNVIPGSAYDIVSTHYVYEDGLVLNAQADWTLRGDFGFAMTYRVNFEGGNLIFENNQVTVNPNEGASFVAELSEDMGYYFEIRAFTEAIVTNTPTTVCAPESAARTIDIIEAEQKSAEAGGSFVTL
>CP034437.1|AZN39622.1|1801145_1801991_+|sugar-phosphate-isomerase/epimerase
MKKGINIWSFPQGMTIAESIRIAKDAGFEGIELALNETGELSLETTEQEIREIKSHLEQADLEICGLATGLYWSNSMTSESEANRTKAMDITRKQLELAAAFNVDTILVIPGAVGVDFIPGSEVVDYERAYDRALECITALAPDAKAAGVNIGIENVWNKLFLSPLELRTFIDTVGSDYVGSYFDVGNVVHSGYPEQWIRILNKRIKKVHFKDYRRQAGGLHGFVDLLAGDVDYPAVVEALTNIGYDGYVIGEMIPSYTHHCEQIIYNTSRAMDAILGRIQ
>CP034437.1|AZN39632.1|1815580_1817260_+|extracellular-solute-binding-protein
MKSRKAIALLTSAILLLAFQAACSNSGNNDNSKNDTATTTNNSTKTNNNSGSTNTATNDTTSDNSTTNTTTDDSAKKEDKTITFATITNYYTAGLQVAADDYHKLHPETTVKIDIISDNTTYQTGFQAKMAAGGDDAPDIVHANLLGDSSANNVKKGFLLKLDDFVKQPNPYNNGTSLWDGVDSAYWPYAYTSDGNIFMVPFDLVGTGFFYNKDLFAKAGISDAPATWEDLFADLQKLKDSSTIPLAMSQATGSDYEGWMVGAFLDWSTRQYVPEALVQAGDAIDTPQVEAINSKVTYSADNPFFDIGAVYNTERQLAFWKSGKYDVTGPAEQKTWSTLKQLSKFLQPGYATMKDADAYQLFISGKAAAYWNGSWQVGQILKDQKSLGDKAFQWGTFKFPDFKDADPNFPGHPRGILVPGHQLAITNKKDAEGVARSEDFLQFLYSPEEAQKVFTTTIDAGQFVQGPSLVKGVTLSDEVNSYLKGFLVAGNMTPMSLITGGNPAAEPNATADMKNLELKYYNDKISLEDYLKQRAALAKKTNEQYIKDNKIDLDPKTNP
>CP034437.1|AZN39633.1|1817259_1818222_+|sugar-ABC-transporter-permease
MDSDGDGAVAIATPVPSFNRTSFSKGDKPMNLIKLKRYGTSYLFLIPSFLFIATFLYYPVFLALVHSFTKWNLVTSTWIGLDNFKRMFNESSFHQAVRNQFIYTFTDVAKAITFPLIGAELIHLLGGNKTKYMFRTGFILPMLLPGVVSYLLWTNIYDPTNGLLNQLLHVFGMNATHAWLGEEKTAIWAIVMFGVPFISGLPFLIFYAAIGNMNYEQLEAARIDGATGWQLFTKMHLPSLRPQFKIVIILTILGSLQDYVKISIMTGGGPGVATTNPAMIMYNAAFGSSQYGYGSAIGVALFLIILVLTIFNLKFLKTDY
>CP034437.1|AZN39634.1|1818236_1819052_+|carbohydrate-ABC-transporter-permease
MERSLAKWTGGTLLTILLILTLFPFAVLIFFSFKTQLEVMIDFWGLPDKLHFENYSAAWKAVRSSIGNSLFVCAATVFGAVLIGSLSGYVFARHKFPLKGPLYMLLIGVMMVPSLLTIVPLYAIINNLHVTHSFWGLILPYISGTQLLGIMLCRTLFESLPEELFEAARMDGGNEFYLYSRIALPLCVPILVTIGIVTFLAVYSDYLWPAIVLDQDHQTFTMAAVGLNKSGRTDIGLSFAAYIIGSIPSVIVIWFGMKYYIEGMTSGAIKS
>CP034437.1|AZN39635.1|1819069_1821229_+|alpha-L-rhamnosidase
MNTQQNIELPLWLWHEKREQHPSFTLSRTFTLEQEVVGVSFHASFTGAARIVLDGELVATIEERAGNAGEWLHIANFPNALQAGEHELKLELSCSSFIPLAEVNYYLWNRLVGAIAYLQGDGLWLVTDESWQADDTQASIICKLGEEPFGDLENSPAAFVAGGYGDIEAYDLNSTTVIGEEALQSAVSNGVVSVTGKHGQDGTLVKPEQQQLELFYHLRKQNEWKAMRELQRGMNLSGASSVTIDLQAEHNCRLAVVNNGAERVKLLWNGAESLHELAHYDGCITEWLEIEPGQTQYTLPQGCRYIQLFVLGEVGQPFALEVKFQSVHVALRQAGTLSSDSEQLNEIFQVSAHTSRICHQIGLWDGIKRDRLNWTFDFYLAAKSCYFLWDDTKVIQRAVRELGVDTPSGHWMNSICEYTLWWLKTVCEYYVQTGDKTFVLEMKEPLQRHIAWVGQNTKPGVGLLPQDGVLVEWVPLTDEERAVALQAIYALTRADLLKLAVAMPELELAIDWPLQTLTSEHYLKQPYALAVKVLGIASGYVSDDAAVAFLDSYQLADPLTPLSAFQLAECYSRYGRHERAYEIIKTVWGGMLDNGATTFWESYTVRPDSSKRDFHDALTTYTAYGSYRMSLCHAWSSTPVKWIGEVVLGIQPLSPGYSKVRIAPTPVGGIRSCKGTVNTPHGDLTVQWHYDEDGAFRYVVTAPPGVTVVEMAGSEQPSV
>CP034437.1|AZN43590.1|1821340_1821910_+|xanthine-phosphoribosyltransferase
MELLKEKIRQEGIVLEGGVLKVDTFLNHQVDAGLMMAMGQAFAELFGEAGVTKIMTVESSGIAPAVMAAYLMSIPMVFARKRKSLTMQSDLYSEKIYSYTKQEESEVTVSKKFLEQGDRVLIIDDFLANGEAALGMARIAEHAGAEVAGIGIVIEKSFQAGRGKLIEHGYRVESLARIASLDGGVVTFV
>CP034437.1|AZN43591.1|1822002_1822479_+|polyketide-cyclase
MKMTNELVRNAVTENDREIINWRVMHAPREVVFEAWRNPEQLASWWGPNGFTNTFQTFEFEQGGQWEFVMHGPDGTDYKNKSEFTVIEAPERVVFKHLNGPHFQMTAIFEEVDANNTKLTWRMLFDTAKEFEMVKSYAVEGNEQNFDRLQALLLEQRG
>CP034437.1|AZN39636.1|1822496_1823117_-|hypothetical-protein
MKLKSEVLSNVMRIMLTILIAVTLLDFVGSLLFAISESLYMDSFNTVFSMISTIKVVLYFTICLVYLVWIYMVHVDLCQFIDPYPRSPLGALAAMIIPIYSFYGLPSTFSRMGHQLEQHSSTQKLGSRIGSLSAPLIILLLFNIVMNRLLQLNSNEAALFIASDIIALALYMLFLLLTRYISQSLSLLAASDASAEVSQQTNVLGH
>CP034437.1|AZN39637.1|1823141_1823759_-|GntR-family-transcriptional-regulator
MPGPSLREQAYQIIYERIISNQLAKGTVTSEVQLSQQLDMSRTPIRAALQQLETEGFVRIVPKHGVLILDSSAQRVGDLLELIAAMLLFTVTSVQLRDEAALSELSGDLLAELATLEGGDSTVLCRFEYHFLTRTIALSHNEEMLRTLERSASRLFWSNNRKRWMAPYQLEMYSCIQSLLHSLTAPAAVNEAISRYLRMLKLTWQ
>CP034437.1|AZN39638.1|1823837_1824479_+|GntR-family-transcriptional-regulator
MVHVEEGKTLRDTAFDVMKRNIISGEWPGGMFLPEKYLSELLGMSKTPIRSALDRLEMMGLVKLSPKQGVIVQEVSLKKILEIYELRLSLETFAVRKLTGKMDDAFFLRLDENLAQQAAAIEREDITRYVELDGQFHEMIVAGLDNEEYTEVMKRIQDKFMLVVRTTFVRNPSRLMGSLEEHWQIRHALTGQDAELSLRLIEKHIEYVKVIML
>CP034437.1|AZN39639.1|1824560_1825709_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein
MKITDIRTYILGNPWKNWLFVLVDTDEGITGLGEGTLNGFAKTVEAAIHELKHLIIGRDPFDVETISLKLFRDVYSDGGQIQGSALAAIETACWDIMGKATNQPLYKLLGGSCHDKLRAYANGWYRGENTPENFFEKAKIVAGKGYTALKFDPFGAAWRTVTRQDFSAAIENIAAVREAVGPDVDILIEGHNRFSVHTALQFADAMLKYEPTWFEAPVPPHLISSMVEVARRSPVPVACGEDYYSREQFAELLRHDAVHIIQLEPQFLGISASKQVCGMVHAHNGVTAPHSAQGPVCSVVCSHLNMATPNFFLHEIFDEFNEPWEENVLQPPLKVQNGFLVPPEGPGLGVELNLEELDKHPYQVGNWLPLFKQGWEKRETVK

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Crispr_ID: CP034437_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_6

1918578-1918652

Orphan

Consensus_repeat	Method
ACGTACCTCTCTTTAGCAGAGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP034437_6

>merge|CP034437|6|1918578-1918652|CRISPRCasFinder
ACGTACCTCTCTTTAGCAGAGAACCAGCAAAACCAGTCAAAGAGGAGTCCCACGTACCTCTCTTTAGCAGAAAAC

>CP034437|6|3|1918578-1918652|CRISPRCasFinder
ACGTACCTCTCTTTAGCAGAGAAC	CAGCAAAACCAGTCAAAGAGGAGTCCC
ACGTACCTCTCTTTAGCAGAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN39698.1\|1917366_1918506_+\|response-regulator	unknown	unknown	gnl\|CDD\|226456
CP034437.1\|AZN39705.1\|1938234_1939842_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369609
CP034437.1\|AZN39693.1\|1912128_1912335_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39700.1\|1933542_1934742_-\|magnesium-transporter	unknown	unknown	gnl\|CDD\|213355
CP034437.1\|AZN39706.1\|1939964_1941725_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270298
CP034437.1\|AZN39697.1\|1915589_1917386_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|379902
CP034437.1\|AZN39708.1\|1942795_1943674_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
CP034437.1\|AZN39692.1\|1907896_1908823_+\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|238257
CP034437.1\|AZN39696.1\|1914252_1915428_+\|fused-response-regulator/phosphatase	unknown	unknown	gnl\|CDD\|369272
CP034437.1\|AZN39695.1\|1912881_1913253_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|225197
CP034437.1\|AZN39704.1\|1936609_1937746_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380491
CP034437.1\|AZN43605.1\|1913308_1914097_-\|lipase-family-protein	unknown	unknown	gnl\|CDD\|238287
CP034437.1\|AZN39699.1\|1918834_1933264_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
CP034437.1\|AZN43604.1\|1910137_1911748_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366944
CP034437.1\|AZN39703.1\|1936205_1936529_-\|anti-sigma-factor-antagonist	unknown	unknown	gnl\|CDD\|132914
CP034437.1\|AZN39694.1\|1912401_1912878_+\|MEKHLA-domain-containing-protein	unknown	unknown	gnl\|CDD\|378025
CP034437.1\|AZN39701.1\|1934912_1935689_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236306
CP034437.1\|AZN43603.1\|1908929_1909595_-\|D-alanyl-D-alanine-carboxypeptidase-family-protein	unknown	unknown	gnl\|CDD\|350624
CP034437.1\|AZN39702.1\|1935688_1936162_-\|anti-sigma-B-factor-RsbW	unknown	unknown	gnl\|CDD\|235217
CP034437.1\|AZN39707.1\|1941800_1942781_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN39698.1\|1917366_1918506_+\|response-regulator	gnl\|CDD\|226456	COG3947, COG3947, Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms].	1.28679e-69
CP034437.1\|AZN39705.1\|1938234_1939842_+\|hypothetical-protein	gnl\|CDD\|369609	pfam07944, Glyco_hydro_127, Beta-L-arabinofuranosidase, GH127. One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.	0.000322313
CP034437.1\|AZN39700.1\|1933542_1934742_-\|magnesium-transporter	gnl\|CDD\|213355	cd12821, EcCorA_ZntB-like, Escherichia coli CorA-Salmonella typhimurium ZntB_like family. A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.51558e-67
CP034437.1\|AZN39706.1\|1939964_1941725_+\|extracellular-solute-binding-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	9.13522e-57
CP034437.1\|AZN39697.1\|1915589_1917386_+\|PAS-domain-containing-protein	gnl\|CDD\|379902	pfam16927, HisKA_7TM, N-terminal 7TM region of histidine kinase. HisKA_7TM is an N-terminal region consisting of seven transmembrane domains found in Archaea and some bacteria. It is always found associated with histidine kinase.	1.26472e-62
CP034437.1\|AZN39708.1\|1942795_1943674_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.95253e-60
CP034437.1\|AZN39692.1\|1907896_1908823_+\|nucleoside-hydrolase	gnl\|CDD\|238257	cd00455, nuc_hydro, nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal proteins similar to the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium, the purine-specific inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax and, pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases such as URH1 from Saccharomyces cerevisiae, RihA and RihB from Escherichia coli. Nucleoside hydrolases are of interest as a target for antiprotozoan drugs as, no nucleoside hydrolase activity or genes encoding these enzymes have been detected in humans and, parasitic protozoans lack de novo purine synthesis relying on nucleoside hydrolase to scavenge purine and/or pyrimidines from the environment. .	2.4516e-24
CP034437.1\|AZN39696.1\|1914252_1915428_+\|fused-response-regulator/phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.81596e-35
CP034437.1\|AZN39695.1\|1912881_1913253_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	5.56605e-44
CP034437.1\|AZN39704.1\|1936609_1937746_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|380491	cd06267, PBP1_LacI_sugar_binding-like, ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.	3.2208e-73
CP034437.1\|AZN43605.1\|1913308_1914097_-\|lipase-family-protein	gnl\|CDD\|238287	cd00519, Lipase_3, Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. .	2.13157e-46
CP034437.1\|AZN39699.1\|1918834_1933264_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	2.46076e-08
CP034437.1\|AZN43604.1\|1910137_1911748_+\|hypothetical-protein	gnl\|CDD\|366944	pfam02156, Glyco_hydro_26, Glycosyl hydrolase family 26.	8.72711e-06
CP034437.1\|AZN39703.1\|1936205_1936529_-\|anti-sigma-factor-antagonist	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	8.61729e-22
CP034437.1\|AZN39694.1\|1912401_1912878_+\|MEKHLA-domain-containing-protein	gnl\|CDD\|378025	pfam08670, MEKHLA, MEKHLA domain. The MEKHLA domain shares similarity with the PAS domain and is found in the 3' end of plant HD-ZIP III homeobox genes, and bacterial proteins.	2.20497e-77
CP034437.1\|AZN39701.1\|1934912_1935689_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236306	PRK08583, PRK08583, RNA polymerase sigma factor SigB; Validated.	1.70854e-69
CP034437.1\|AZN43603.1\|1908929_1909595_-\|D-alanyl-D-alanine-carboxypeptidase-family-protein	gnl\|CDD\|350624	cd14852, LD-carboxypeptidase, L,D-carboxypeptidase DacB and LdcB, and related proteins. This L,D-carboxypeptidase family includes LdcB LD-Carboxypeptidase from Streptococcus pneumoniae, Bacillus anthracis, and Bacillus subtilis, and L,D-carboxypeptidase DacB from Streptococcus pneumonia and Lactococcus lactis. These enzymes are active against cell-wall-derived tetrapeptides and synthetic tetrapeptides lacking the sugar moiety but are inactive against tetrapeptides terminating in L-alanine. L,D-carboxypeptidase DacB plays a key role in the remodeling of S. pneumoniae peptidoglycan during cell division. It adopts a zinc-dependent carboxypeptidase fold and acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem. This family also includes vanY D-Ala-D-Ala carboxypeptidase which is vancomycin-inducible and penicillin-resistant. VanY hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors; it is insensitive to beta-lactams. All these enzymes belong to the MEROPS family M15 subfamily B.	5.7307e-75
CP034437.1\|AZN39702.1\|1935688_1936162_-\|anti-sigma-B-factor-RsbW	gnl\|CDD\|235217	PRK04069, PRK04069, serine-protein kinase RsbW; Provisional.	2.01569e-55
CP034437.1\|AZN39707.1\|1941800_1942781_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	3.71053e-102

>CP034437.1|AZN39698.1|1917366_1918506_+|response-regulator
MKVILVDDEPMMHLIMGKMLDKLPGIEVAGAFVNTKQAAAFLNENDDIGLAFVDISMPDETGMAFTAKLEQARSPVQIVFVTSHKEFALDAYDLSVTDYLVKPVSQERLARTVNRALAIRTAHGSLDASRETAVCAAPRMNVTTLGDVSIGSESLRVKWISRKCAELFAYLLLHRGKRIPRSRLVADIFGGMHLENAVNYLNTTVYQLRKSLEPLGLRENVRSENDGYALELPQEAFIDYAVFEQQVRNMQSIDAGNVEEAMQAERLYTGDLFGDKAYVWAIHETERYAELYGAFVIRIAGALIAMNDTSSALKLLSKLNERNPLDERVIRLLMEVRCATGDRKGLTALYTSYVRLLSRELGIRPSAELAGYYDELVAR
>CP034437.1|AZN39697.1|1915589_1917386_+|PAS-domain-containing-protein
MSTLLFIAAALMAFVAVLSYRKRHMSVARTMVLMMLAGAFYALGYGMEVLARSLEQVKLALQIEYIGIPFVTTLWLYQAIQFTGTAERYRRKLAVVLFIFPVLLFVLHLTNDWHHLVYASYSLNEEANVPLYTTAKGVVYNLHALYSYVVLTWGVGLFVSMYIRALPAVRKQILILLLGAFAPMAFNLLFWSGVKIDFTPFGFAVSGIAYAWGILRFNLLRLTPLALAKVFETIRDGVLLLDGEGRIVSYNGAAARIFPELESAQRRYPAPAGGILTAYPDLLQLIESDHARDERFPFQRQLGGRSLHYSCSLSIIYDAGTLPVGKMIMFNDVTELIENEVRLRENARQLSELNAFKDKLFTVVAHDIRDPIALLVSLTDLLGDELTAADIEHAELFVELRGQVQSTFHLVDNLLDWYRSQKGAVVFRPSGWNMRQVVLQAMSLASPKAGMKAIRITERIETGLAVEADKEMLDLILRNLLSNAIKFTDVGGEIEIGAESEGGRIAVFVRDNGAGIDDKTSDMLRLEEPFSKGAVSGGDSGDTRFGLALAREFVRIHGGVLRFESEPGIGTTFTFTLPQAASSSYYGEEEDGDESHTG
>CP034437.1|AZN39696.1|1914252_1915428_+|fused-response-regulator/phosphatase
MRIAVVDDNPMNITVVREILKRAGYTDIESAGSAGELFLHLGLTVQGEEPKDGPGNDGHGIDLILLDMMMPGIDGITACAMLQRSARLKDIPVIMVTAIGDSKKLAEALDAGAIDYVTKPINRIELLARIRVALRLKVEKDWHKERDRRVREELQLAREVQLAALPHKLDDEGVAIDAIFRPSEELSGDLYAWNRIDDHRYGIAVMDAMGHGISSSLACMFIASVLKEAMSKQVEPKRVIRELNRRSLQLQFADQLIQYYFTGLYMVVDLIEGVVEYVNAGHPPGMIIRQNGEVETFAQGGVAIGMFGDIVVEKHTLPISSGDRIVLLTDGIYDLVGSDSEEDRPASLTTLLQPYGSTTSLGELEAALFQEGHHAEELQSDDRCLVVVDIK
>CP034437.1|AZN43605.1|1913308_1914097_-|lipase-family-protein
MSSGSTIDIRTAIFLAAVCGQTYSQYNNNGYFLVPDSYRVVGPFNASSFTGNEEPFGFVIESPQAVILAFRGTSSPTDWVTDMIAQQTIFKPLSKKSVMTHRGFTEVYMSARDQIFQLLDQVPSDKPLFVTGHSLGGALATLASVDIAVNRKPNTIIAYTFGSPRTGDPAFVRAYNSAVPISFRIQNEFDVVPHLPPLVYQSPKTDKSYYYLHVKEEVKRSFRHGTLGGNHVISSYFNDLAQDAPGFTAAVCSDPRGWCPQK
>CP034437.1|AZN39695.1|1912881_1913253_+|MmcQ/YjbR-family-DNA-binding-protein
MEALIGHCLSKAGAAKEYPFGPDPIVMKAGGKMFALISGDGSGISLKCDPVIAENLRQQYEAITPGYHLNKKHWNSITLDGSVPVPELLDMIDHSYELVLKGMTKAERARISEAGAAAQTVRK
>CP034437.1|AZN39694.1|1912401_1912878_+|MEKHLA-domain-containing-protein
MEKLGIGSTERHANIILDSYHRLLGKPLVEREAAQESSAALLFDAPIVVLSHGTQADPVLNFGNRAALELWEMDWSAFTKIESRHTAEPMIQEERQRFLEAVATQGYIDDYNGIRISSSGRRFRIEQAIVWNLYDEDGDYYGQAAAFKNYTFVQEGEC
>CP034437.1|AZN39693.1|1912128_1912335_+|hypothetical-protein
MSENETTPEVQEPKKVSLAEAVKQKLAQKKQEQANGAGKQKHGPGGNQQTMKSQNHKKVNNQRKKMGV
>CP034437.1|AZN43604.1|1910137_1911748_+|hypothetical-protein
MTFARKLILAMVTIIVAFTTIHTYEAHAMNVWGIYKEAVALEQKGKYAEAIAKYKLIIPEFVNKKEYGNSANMYRYVGNDYAKLKQYDDAVAAWDKEAEYSGKANQTQISIAAKRKADMLRSSAKLFVETKAGDVGTSYTHGAKFEPKNGAYIGAYAERDPAVHNAATSKPFYTEKFPELTGKKHAAYLFYFTYGQPLSTIKSHLDHARDAGTAIELGVQPLKGLSEVQDNEYLHQLARDIEASGVKVFLRFANEMNGDWVPWHADPKAYIEKFRLVAKVFHQEAPNNVAMVWAPDRQPEYSIESYYPGDDAVDWVGVSLYSIFNPTLDPLKQGEDRSSHLEKFDFIYKTYSARKPVFISEGGVAYMYPEKQQDKTSWAIYKMKEFYSTLPMLYPKVKAAFWFDSNHDQTAASTRMKYYMLSANEKLLNAYKKSVSNPFYLSTVGDESPVAYKPVNTASAVTAGTQKISAYMKTWSPTLSKVTYEIGGKLVATATDTPWTASINFAPYKGKKIDVVLKAYSNNTLITTQKVAVSVK
>CP034437.1|AZN43603.1|1908929_1909595_-|D-alanyl-D-alanine-carboxypeptidase-family-protein
MTSSQAAFQAYMHDNSPALTITKNAGGKAIVTNTNSTLVLVNKKRELDSTYTPKDLVVAKVTFSFSGTSPKQQLRAIAAQALEKLFAGAEKDNIKLAAVSGYRSYASQKSIFDNYARKNGEDEANTFSAHPGQSEHQTGLAMDVSSASVNYNLDESFGESKEGKWLAAHAADYGFIIRYEQGKEGLTGYMYEPWHIRYVGVVVAQQVKKNNETLEQFLAKF
>CP034437.1|AZN39692.1|1907896_1908823_+|nucleoside-hydrolase
MSIFPVLSQQKLLQRLAHPQRKIRMVLDTDTYNEIDDQFAVIYAMKSPESMTVEAFYAAPFFNDLSTGPKDGMEKSYDELKRIASIVPEMEGVPIYRGSESYLLEAGAPVESEAARNLVERAMAAPDDDPLYVVAIGAITNVASAILMEPRIIEKIVVVWLGGHALHWRDTTEFNLAQDLHASRTILDSGVPLVLIPCGGVASHLSTTLSEINDYVRETGPIGEYLYETFKNCHPNHFGYSRVIWDISTIAFLNNEEWTPSTLVHSPVLSSDFRWSVDRNRHFIRCVEHIHRDSVFKDLFRKLDSNIN
>CP034437.1|AZN39699.1|1918834_1933264_+|S-layer-homology-domain-containing-protein
MKGEYVMEFIKLGKRSKLFVHWLVIASLVCGLVFPGNGYANGTEAAVSSSAPTDIKGHWAESTLTDWLGKGYIEGFDDGTVRPDASISRIEFVALANRLFAYKGGSGSSFKDVSASAWYASDVSVAVHEGYVSGFPDGTFRPNKTLTRVEAASMLAKLAPVLVREGADPLAAFKDQSSVPAFGRYALGAALDGGLVTGYPDHTLRPTATMSRAEAVVILDRILKHSVPKAAGGIVVSAKSLQEAGTYGPEFGTITVAGNLSIDVPGVTLRNVIVKGDLTIGQAVGDGDVYLDGVTVTGTTAINGGGEHSVHINDTKLGTVIVEKKEGSIRVVVDGTTVIEQLDVRTDARIESNGTAPESGIEGISITADGVVTLTGKFSLVEIKSDVKLIVEAGSVDQLVVNENVGETTVTLNEGVKVANAELHGTTNVQGTGEITKAIVDAPNVVFETEPLQLEKTDRGGEDSDVPIGGGGGGGGGGVITPPNPTTTVSVTASQASSSGVKLNFSTAVTGLTPSAVTLQDSGGHHVTVESVTALDGGLSYQVAASLLEGQTYRVTLAKAGYDFGSAVSFTVTETPPQTIHIEASVTNISTAGFKVVFNQAVTDPVFTLKQGGDTVAIASATSSDDGLSYTIAAALTEGSTYTLAAAKPGYDFGNPTSVHVPVTTPNTVEVTASQASGSGFKLNFSTAVTGLTPSAVTLQASGDQPVTVESVATLDGGLSYRVAASLLEGETYRITLTKAGYDFGSAVSFTVAETPPQTIQVEVSVTNISTTGFKVVFNQAVTDPVFTLKHSGDTVAIANAASTDDGLSYTIAADLTEDVTYTLTMAKQGYAFGNPTSVYVPVTTPDIIQVTASVADISEAGFTVTLDGAVDGLADGDFALTDMNGEPVDLTAETADEGATYTIAAALTAGGSYTLAMTKSGYSFGEALAVVVPGMLDIVVSPSTSNVTMAGFVLSMDQSVPDMEPLSLDLRNSDNDPVGIDMLSAVVVGSQYEVWAALDLNETYTLTLNKAGYSFDAPVAIEVMPERISASVSQVSHGSFRLKFDTPISGLTTDQLALTDANGQSVDVSGLRSEDDGLTWIVEADMAAAGMYAFRVDTPDAKYAEGDVVVPETIAVGRYATINGPYSPQYTGYTVHLDRAVPGLDASHFTLTKANGDSIVPTAVETIDNGLTYTLQTTEVNAGGPFTLGMSAPGYDFGPPAVIVNATLNPWNTSKRPPQFMAGFNPAIPNMTKDNFHVVDESGAEVEVIEVVWDNQMHLYIGKFAGTNGHTYTLSARADGYDFGAPKQIRVSGRNEITEVSTTGVTLSLSPALVLDTSKAFTLKTLAGATVPITSVTTNDGGATYRISAALTGGEYMLSMNADADPNQFYINIPILSAITVGGVGNDGFTVTLDHPISGLWEGSFQLSNVSTGDSLTITSASSSDGGQTYRLDAALPGGTYNLKLIGHLPVDGVSFQVADTLDAGSTTITKITNAGFELSFANAIPGLLPANVDIRDSANKRLTGVTLATDDFGATYHVRVQLVSNQDYTVTLTKAFASFPSPLTFHVNRFITGSVTDVTIDGHLILRFSPAFPEIENYLGLKLKDENGQPVYPNGFESSDHGASYRVTVPGGFHPGATYTYALELDGFEMKPVAFDVPPSMTVESASTTGVTVAFASPVSGLQIRNFVVRGQQGETITMTSAATSDGGSTYTIAGALASGKTYTIQYKPDAASQVNEPVPFVITKLVTATVSNPTMTGFKLQFNTRIAGLLPGQLILRDPDGNRIYVNQYTLVTADQGLTYKVTTSMLQAGNGYSVDLDRSEFKLGSPVLFNVPVTAQTQLIGTQTNLIAIQVLPDMPDLTATNFVLVDGTGRTVAITVTYKGGAIYHLTGVFDPNLTYTLKTTVPGYAFGDPIPVAYVVKVDAVVLRQNQSGFTLNLRPALPGLIASDFHLTDTGGNTVAITSAVTSDNGLSYQIHAALVAGKTYTVSTTKAGYSVVTSDPFSLTSKRASIDRVSVHGFMLNFTSPMALLDTDLALTNEQGDPVKVSFVSWDGGLTYQVYAELSAGVQYSLSINKMGYDFGAALTFSLQAVVPTFEGTVVGNVNAFTLSFSQPVLGLRASDFVIMREGWGQPIPVQQATTADGGSTYLIETTFWGAAHYTVLPKKDGYDFGAPVEMDVPVAVSAAVRRAGATYVDIGLNPAVPGLQASDFQLKDDNGNTLNAAAAVTTDDGATYRVTAAFIGAQTYTVLPVKQGYDFGLASSVFFPTVIMVQQAGIDVNGLAVKLSPAIGGLPSSAFELRNSDGELVMVHAIDELNDGLAYALKASLTEGETYTLSIHADGYDFGTALSANVPITVGMDYTDISAGGFDVTLDKAVSGLTSGNLELTDDQGAPVTVQSVVSDNDGLRYHVAAALTEGKVYTLTLTNSGYDFGIGRTLYVPVSVTAALKSANAAGISIRFQTAVAGLTKSSFTLKDAEGNTTIIQSATTADDGVTYVIAADLTDGKRYNLTVTASGYVFGEPIAFEVQTITISSVNTSGFKLGLSTAVPNLSPSLVLLKDGNGNTINLNASTFFDENPNSPSKGKSYAVLVPITAGVVYTIELIDPAHPTTGLSEVVLPIRVQSSVIAANANGITLSLSPKQINLLPADLAIETAAGDRIPVSSIVAGTTAGQFIVQAPLSEGSTYTLTFTRKGYELASAVTAYVPITAVAAVQAVNESGFILTLSAPVSDLSITLIDSLGNVVAPVTTTASDEGLSYKVAFNMGYNRNFTLKLSKSGYDLGGDRIVNNVSSAPKLIAATSDESGTKVILTFDKAMKPTDSTSFSVKIDNQWQSNVRSVLGSDPKTIILTWSAAGKIIGSTATAMVAYAGVNRVQAVNLLFLPTFGETPVSNAGTVQGFVSSSAALDSSAVYPAQVLRGQYGLSALEALKVLREGGFTVASYTRAIYAVYDLSKEAIIGLFGEMEADATTMLQGQDAMFDQSYPFYVRDMMKAGYAPIEFGPFLRKHGKTSAQAVMQLKVAGAVGVDAAAMLRSSYDETAGSAASLLKSSGYGLQEAAAAVQHAYELSDANTILALKDGGWKAIEAASAMKVQLSTGAVAMARALAEAGYAAAVIGGAVAQAYAFDDAGAAVAVFVQAGFSAPDTYGIVRGSFSQVETAKAMLNAGVSSVEVASAVLETGDSPAVVIQAMKSVQADDLLIAITIKDVWGVSNASEAMKTFGANGYDLAKRAGLLRLAYEADIKAAVSALYDGATNEERNNLLRYLVKGGYDPIATTSYFLHNVRGAGRSSVLNQLKQAGLTTSQALKTLHDAIVEDGTPFSLNDAILILSGDYTTRYTAADAVAGLLTAFAGDSGTTTDITSIAATVYSSRLWDKYEIAGALKSLMGMNLQQWIALERTNAMADCPCSVITIRKDAEYLYSGTTLADLTVAMSLSGQFTLDELIDGTIGAYGYSGAGQALPYLTSALKNAGYAFEDIAASFDRRGWSEWILAFSRYGIAASEVAAYLIGKQETMDQVIRKLAPYSLRDIALVLRENYRLSDLDATTAMITSTGERSDDIAAAIAWAYGSDPIMLWIQTLRAQGATATSVINTLAAHYPAYRTYDALGPALIKGGFSRDEVIQGLIVRFSYGNNLPGTIKLIQSLYAQQQITIAQLLTASGSATPESGIDFLALGGYKLSDMAGSLKEFYGLKAGEAAYALSKKYPNNVNAVLMALSTVYGQTIETTMAEALDAQGISTVEAAIEYLRNAGFGFRDIAAVVKERFARDAGQIAALYAAGHTVDTNVVVTTLASLFGQSVESVVHDWLMAQGTTSYTAAITFMNRANFSLASIVKLAKNEYGLSSGTALQALVASGLYPQTNVVGTVADVYGSGQNETIVDSLTANDLLTFDQAVPYLRKMYFGLTALVRVGKEYYSLTSGEAIDVLSVTTDYSSSEISSAVQNVYGQTLQQTQLSTLTNMGIGTFAEAITQLRALDFSLRDIVLAAKTYYGLSAGKATYDLLHDGHIDATDVLNEIAELYGQPIDQSLGQLLDESGLATIEEAAPFLRSLGYAMQDVIEASRSYYGNGADSTIQALISVYPESDSVIEWTVLQQYGEGGQASVAQAARDSLQAADIKDAAAAITHLWSAGFSLLDIAGLLKTDFSQSAADAAKLFLTSGSFEPAAIVSSIGAVYGSTYDSPYVEALKTAGALTPEQFVSLMNAGGYRVAYIAEALKSNYGKTNVETKAILTAFAQYSAAAVQSTVDQVYGTIATSGTLQEVLDLFGIKTADGAAAFLHQQNTPVKDVVQYLKDAYALGADESTTVLSPYYAKTELGLAIVAIYYGDKNVGYLTKMIPPDRLSTPNSVAVYMSDKFGTTDIVLALKVIFGLDALGVTDAIRNEVIPAEKVRAAVTEVFGADPLYAYLKRMKDKGGSANDVAAELARRGVLETTNASYLIDTLASLGFDNASILKMRYNYYNRTLQNAGTNEEQGTQLVRLGVNTPEAIVAFIRTTGTPAIDTIAIVKAGLPNADMTAIAKAMYNAGYEKQALMGALRFHGEHGDGVAALLRTFGLSVQDALSYLGDRSDDEQLRWLIRDGYMPSEYIRYMDVRSDNSIAILKENGYTAEQLGTLLGNLNMEFYAIADALYHGGFTNVPDLSRALIAARSRVVWIPQILDEIGGWTLQQVAQGMLDSGLISLVELVSALQMANGNNLKNTYQIIKAISGKEREAFYNELSSGEKRLIDDNEVAILLTVSTFREAGISITDIALQLRNTEVIGFEDGAKLMGLGGFNVGDILSTIWDVYRDEIGIMIIQKMIEKVIGNYFAEFKNYIKLIKLVTKIVRRYA
>CP034437.1|AZN39700.1|1933542_1934742_-|magnesium-transporter
MMHRLLQFPSKWEWLVLHEPRPESSGLSRSSSRAAGGGYAEAALAGHAEEQAEVKQASAAAMKQAYPELAGWMSEIEGNTHNQIIVSELAGGESVLQGTLMFQVSEDETDVLPLHFRVTKSRLVTFAGDMRLSVRLQLDPWQDKLNRCQSAPEGFFVVLGSILETFHVGLDRFETRLGDLEHKMRKQNRTGLMNTIFERRYELLHWSHLFIPIKEIQGAAKEAFMDTLLDQEEYKRMELKLERIEALLKHYAMEIDTLLMMDDAISNFRGNDIMKTLTIFTALFMPATVIGAVWGMNFKRIPWAGEPWGFVAVCSIIVVVTLLIYWWLWHKGWTGDLLNGRHRGEIVGVDTPIDAAAGDGTPRPLPSRSSRARVTQSAGSASGTGSDEQDTPLPSRSSR
>CP034437.1|AZN39701.1|1934912_1935689_-|sigma-70-family-RNA-polymerase-sigma-factor
MSTQPANHRSAGGIELITAYQNNPNNETAELLIVHYEPMVRMAAGKISRNRPDLYEDLIQIGQMALLRLFSQFDSTLGVQFEPYAMKSIIGHMKNFLRDKSWYVQVPRRIKEKGIALQHAIDELTVSLERSPRMDEIADRMGLSVEETTEILAGRELYHYVSLDTPISEEDSTSTLGDLLGSPLDDFENVDKRLDLEAAMAQLEPAEQRVLLLAYQDGLPQRQIADILGISQMSISRIQRKATLKLKKLLSEQDELDD
>CP034437.1|AZN39702.1|1935688_1936162_-|anti-sigma-B-factor-RsbW
MNDKEDLITLKVPAAAEYIDLVRLTLYGLAAKIGFSYEEIEDMKVAVSEACNNAVLHAYGDIRSRSVLTGGGAPQIEVRFVKKYDALSIIVKDDGSSFDAAAAAKLAQPVDGKTIDELQAGGLGLYLMQALMDDVIVSSEMGTEVILTKRLIRSGEL
>CP034437.1|AZN39703.1|1936205_1936529_-|anti-sigma-factor-antagonist
MKHTDKLVLRTVNQEGKCTVYVGGELDLESAVQMRAAMTPLIELTDCELILNLQELRYVDSTGIGILVSVLKARHAKEAPFAVTAVPPHIRKLFDMTGITPFLLKQA
>CP034437.1|AZN39704.1|1936609_1937746_-|GntR-family-transcriptional-regulator
MSVPMKRVPLYTQIRTYIADQITQGNLKPGERLPSENELAEHFGVSRITVKGALSTLVEDGSVYRIQGKGSFVADGPQSKEPVLYPPANASASLAALVKPRKMKLISLMIPSLKTAYMVHLVQGVEKQAALGGYRVIVSLTHESVETECTLLAEADEFGVDGVIVYPIEGESYNEDILRMSLRGYPIVVIDRYLKGLETNCVCSDHFGGAYEATNHLIQSGHTRIAFLTAPAKGTSSMEDRLEGYRRALSDHGISSDPRLVFTNTDPLQIERFLRESTDVTAVFALNSSLGLKVMTAAERLEFSIPEQLSVIFFDDLEHSYRWAKRPSCVLQQEEEIGIQATKLLLSLAENPEQERKKIVLPPRLVVGGTTAPPYNFT
>CP034437.1|AZN39705.1|1938234_1939842_+|hypothetical-protein
MMVMDVKLQSRPKTYFLQEAIERGFTAIANRLDREQNYRPYFLLRLRPQPQLEHHIWDLGDMCSRFTDAYLLGRSVTGSSAYKEEEEALRAMLDTCDPFLNPFMAGRMLLAYVDLYLDEPSEERRETVERLAASIRDNVQHEGDYSYWFKNADGWNTMEHAVFGDFNGYPTFPLGGIMLALARFTESAHDAPDCEDLLDRMCRFVLNVSGTFEADGRYQGHTHSGGILTAAVAIMRRALQKNDAAVAQQMKHVFDWTLRFSSKWGWVPDGVGPDDASCESCSITDTLHLGLLIARHMDESYYAILERFARNQLLENQFVHTNAMLPQGDYPEKPILERALYGSWASWSKPGSLDNCVESVEGCCLGAGIRACYLVWDDIVTKKDGVVSVNMALSRNSKWVEVVSYQPYEGKLELLIHEAEVLRVKLPDWIAREDAVLSVDGEALPIVADDSGYIRLEGLQPGQLVQLLYPLTTIDSIERVSGSDYNVRWRGDTVLSVTPSGQIYPLYQRKWMEQDHAPMTQGIPYAEQRGGNVHW
>CP034437.1|AZN39706.1|1939964_1941725_+|extracellular-solute-binding-protein
MRIRQNVGILLTAALTVGLVGCGGNNGSNSTSSSNNSGNASSNAANSTNTTNSANTSNSTNSSNNGGTSNTSSEEVGTVDNLKITAFNWGWDNADPAKDVVLPELKKRLGLKDLTYDVIKTGGYDDVVQKLQLWASTGGSDWPDIVTTGSDSRTKLILNNLGESGKLEDLTPWLEKYPNVKNAVEKLLPFTSDPHDGKIYSIAQNFSNMQAYAIDQPTIWIRKDWLDKLNLPLPKTVDDLYNDLKAFKEQIKDVNGQPVIPYAAFGENFRNMIKLFFPPDQNDGTGVWYTDANGKPARSDVSQSDNLIRALTFYNKLYNEGLIEKEAFTLKQGQIDEKGNQGRYGAVHGAYWEQANPFTDSMKKTDPKAEFVGVQLYDPTIASGPSLPKFRLEAWSLWAVKAGLPKEEVNTFFKTLDYVLSEEGTILTKYGLEGQQWERNADGKIIDTKAFFDETQGDWNKRAHFGIDVYSFIPNYDALIKNQAPSGYELREDMIETWKNLGSKFPTEYVTDPQRYVEPGDVENKATVGQGERYKQLVAKAVTAKNPDGIKKLVEDWGKNVKALGYDKIVAEREEAAKSIHLENLK
>CP034437.1|AZN39707.1|1941800_1942781_+|sugar-ABC-transporter-permease
MATLAESQTNTAVEARRRAMTKRILHKMWDQRWLYIFTIPGIIFFLLFSYYPMVGIIIAFQDYNPVKGYSGSEFVGLENFKTIFNLPDFTNALRNTVIISGLKLLIGFPVTILFALLINEIHQTVFKRFVQTISYLPYFISWVIAAGLWYKMLSPDGGLINEMLTRIGFLNEPFYFMGSTHAFLPIVIFTELWKNIGFNAIIYLAALSGIDPHLYEVSSIDGASRIRQIWHIALPGIRGTMVLLFILSASGLMSAGFDQLWTMGNLQVQEVGQILDTLILSYLRNSGGFMGLSLGATMGVFQATVGLILFLVCNFVAKLIKQESLI
>CP034437.1|AZN39708.1|1942795_1943674_+|carbohydrate-ABC-transporter-permease
MQRSRGEKWFNVVNMLFMLVFSFLCLYPFIYILAISFNDAMDAQKGGIYIWPRMFSLKNYEVIFSDQNIFLAYGVTVARVVVGVITQVLLVAMFAYVLTKKNFPLRKFLNWWIVIPMFLSGGLIPFYITLQQLHLLNSFWTYIIPGLYGAFNIMLVRTFMTELPEALEESAKIDGASDARIFFSIIFPLSKPVLATIALFVGVSHWNDWFTGFTFISNTKLWTAQNLLLFLIQSNEASNLAVLSKMHQGAVTVTAESIKMAMLIVTTAPILCIYPFLQKYFVKGIMLGSLKG

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Crispr_ID: CP034437_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_7

2160674-2160852

Orphan

Consensus_repeat	Method
GGGAAAACCCTCTCTCAG	CRT

3 spacers

The CRISPR arrays of CP034437_7

>merge|CP034437|7|2160674-2160852|CRT
GGGAAAACCCTCTCTCAGCAGTGAAAATCTCCAAAAACCTGCGTGAGAGCGGGAAAACCCTCTCTCAGAGGGAGTAAACACATGAAACCCTCCCAAAACCTGCACGAGAGAGGGAAAACCCTCTCTCAGCAACGAAAATCTCCAAAAACCAGCGCGAGAGCGGAAAAACCCTCTCTCAC

>CP034437|7|2|2160674-2160852|CRT
GGGAAAACCCTCTCTCAG	CAGTGAAAATCTCCAAAAACCTGCGTGAGAGC
GGGAAAACCCTCTCTCAG	AGGGAGTAAACACATGAAACCCTCCCAAAACCTGCACGAGAGA
GGGAAAACCCTCTCTCAG	CAACGAAAATCTCCAAAAACCAGCGCGAGAGC
GGAAAAACCCTCTCTCAC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN39873.1\|2150539_2151274_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236722
CP034437.1\|AZN39872.1\|2149621_2150395_+\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
CP034437.1\|AZN43625.1\|2165732_2166608_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
CP034437.1\|AZN39877.1\|2157968_2159021_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
CP034437.1\|AZN39871.1\|2148610_2149489_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
CP034437.1\|AZN39870.1\|2147756_2148551_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
CP034437.1\|AZN39878.1\|2159231_2160461_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
CP034437.1\|AZN39876.1\|2153400_2154573_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|182528
CP034437.1\|AZN43623.1\|2154843_2157882_+\|DUF4981-domain-containing-protein	unknown	unknown	gnl\|CDD\|236548
CP034437.1\|AZN39880.1\|2161912_2162677_+\|DUF2087-domain-containing-protein	unknown	unknown	gnl\|CDD\|378279
CP034437.1\|AZN43624.1\|2163222_2164407_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
CP034437.1\|AZN39881.1\|2162745_2163174_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198398
CP034437.1\|AZN39874.1\|2151270_2152710_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|223914
CP034437.1\|AZN39875.1\|2152709_2153435_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
CP034437.1\|AZN39882.1\|2164538_2165657_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270272
CP034437.1\|AZN39886.1\|2170025_2170763_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39879.1\|2161197_2161716_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN39883.1\|2166600_2167491_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP034437.1\|AZN39884.1\|2167534_2168893_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
CP034437.1\|AZN39885.1\|2168911_2169874_+\|TauD/TfdA-family-dioxygenase	unknown	unknown	gnl\|CDD\|225086

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN39873.1\|2150539_2151274_+\|hypothetical-protein	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	0.0050986
CP034437.1\|AZN39872.1\|2149621_2150395_+\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	4.80213e-34
CP034437.1\|AZN43625.1\|2165732_2166608_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	4.71934e-132
CP034437.1\|AZN39877.1\|2157968_2159021_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	5.38665e-24
CP034437.1\|AZN39871.1\|2148610_2149489_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.34145e-26
CP034437.1\|AZN39870.1\|2147756_2148551_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.68704e-17
CP034437.1\|AZN39881.1\|2162745_2163174_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198398	cd10451, GIY-YIG_LuxR_like, GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria. The family includes some bacterial LuxR and ArsR family transcriptional regulators. The a C-terminal conserved domain shows sequence similarity to the N-terminal catalytic GIY-YIG domains of intron-encoded homing endonucleases. Besides, they have an N-terminally fused transcriptional regulators module, comprising the winged helix-turn-helix (wHTH) domain and uncharacterized domain DUF2087. At this point, they are distinct from GIY-YIG homing endonucleases, which typically contain a variety of C-terminally fused nuclease-associated modular DNA-binding domains (NUMODs). Moreover, some key residues relevant to catalysis in GIY-YIG endonucleases are mutanted or absent in this family, which suggests that members in this family might lose the catalytic function that GIY-YIG endonucleases possess. This family also includes many uncharacterized hypothetical proteins that consist of a standalone GIY-YIG like domain.	1.00635e-26
CP034437.1\|AZN39876.1\|2153400_2154573_+\|FtsX-like-permease-family-protein	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	3.30155e-64
CP034437.1\|AZN43623.1\|2154843_2157882_+\|DUF4981-domain-containing-protein	gnl\|CDD\|236548	PRK09525, lacZ, beta-galactosidase.	0
CP034437.1\|AZN39880.1\|2161912_2162677_+\|DUF2087-domain-containing-protein	gnl\|CDD\|378279	pfam09860, DUF2087, Uncharacterized protein conserved in bacteria (DUF2087). This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids.	3.17392e-26
CP034437.1\|AZN43624.1\|2163222_2164407_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.47173e-56
CP034437.1\|AZN39874.1\|2151270_2152710_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|223914	COG0845, AcrA, Membrane-fusion protein [Cell envelope biogenesis, outer membrane].	3.23418e-28
CP034437.1\|AZN39875.1\|2152709_2153435_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.72522e-121
CP034437.1\|AZN39882.1\|2164538_2165657_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270272	cd13554, PBP2_DszB, Substrate binding domain of 2'-hydroxybiphenyl-2-sulfinate desulfinase, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes DszB, which converts 2'-hydroxybiphenyl-2-sulfinate to 2-hydroxybiphenyl and sulfinate at the rate-limiting step of the microbial dibenzothiophene desulfurization pathway. The overall fold of DszB is highly similar to those of periplasmic substrate-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The DszB protein belongs to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.6484e-53
CP034437.1\|AZN39878.1\|2159231_2160461_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.57442e-99
CP034437.1\|AZN39883.1\|2166600_2167491_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	7.65057e-75
CP034437.1\|AZN39884.1\|2167534_2168893_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
CP034437.1\|AZN39885.1\|2168911_2169874_+\|TauD/TfdA-family-dioxygenase	gnl\|CDD\|225086	COG2175, TauD, Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	1.19167e-95

>CP034437.1|AZN39878.1|2159231_2160461_+|MFS-transporter
MATASVRSAAVQTGTIYAILFAISSVHLMNDTMQAVVAALFPILQKSLSLSYGQIGWIAFTLNMTSSVMQPLVGYFSDKKPAPWMLPVGMGLSLIGMAGLAYAPGFLLVLLAVVFVGLGSAIFHPEGSRVVYFAAGGRRGLAQSIYQVGGNVGSALAPLMTIFIFVPLGQPGAIWGTLLAASAIVILLRVVPWYREQLEQHGKPVKRAAAKASGSVAVRQLSRSTVTMALGILILLVFARSWYMSGISTFYQFFAENKYNLSVQEAQVPIFLFLAAGVLGTFFGGVMADRIGRKRMIVLSMAFASPFAIILPHLPLGWIYPIAFILGFIMLSGYSVSVVYSQELLPGKVGMASGLITGLAFGMGALGAVVLGKLAEEWGLDRMMTTSSFLPLIGLLAILLPPDRREEAA
>CP034437.1|AZN39877.1|2157968_2159021_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MQIRRSRSRSRRGSLLRLTLAGTIAVSLLSGCSLLPAEEESLQPPILSKKEEVHDTAAVARGNMALYLTSIATAASDTNNNVSFSETGGILKKLHVEEGDKVKKGDPIAEIDTGDLPLRIKLQKLTVEQRALQYSDYVKNGADNDTIQFAKIDLEKEQLQLGSLEKQYAKALLLAPSDGIITYLNEMKPGEAVEAQRVMAVISDPNKVNFVYEATDISKISAVKPGIEVDLTFDDKTYKGKVIQTPASAPKSDDESIQRRNARSLIISLDAPKAPIKIGTMADIKLFIEKRDNVLVIPRGALQTMFGRNYIETIENDRVKEVDVEVGLKTNDQVEIKQGITEGQKVIIDN
>CP034437.1|AZN43623.1|2154843_2157882_+|DUF4981-domain-containing-protein
MKAHATLMPFDSVEEALKGDREASRSRLSLNGMWKFAFAETPSQRIVNFYEEGYNTSDWAEIKVPAHWQLQGYDYPQYTNIRYPWEESEPELMPPFAPTKYNPVGSYVRSFTVPEDWAGQPVFISFQGVESAFYVWVNGDLVGYSEDTFTPAEFDLTPYLRAGENKLAVEVYRWCDASWLEDQDFWRMSGIFRDVYLYTTPKAHIYDFFVLTELDDAYRDAELKLKATITNYWETQLGTVTVEAQLYDSEHKPVLAQPLVVTTTLGANEAEVDIDASVLVANPLKWSAEEPNLYTLVISLKDHEQQLLETISSRVGFRKFEIKDGLMLINGQRIVFKGTNRHEFSCHTGRALELQDMITDIKLMKLYNINAVRTSHYPNQPVWYELCNEYGLYVIDEANLETHGSWQYDQLELVPKNVPGSNPAWTANVLDRANSMFQRDKNHPSIIIWSLGNESFGGDNFVKMHDLLRDADPSRIVHYEGVTMWRDSAAATDVESFMYAKPHKLVEYAHDFRPKKPYILCEYSHAMGNSCGGLHIYTELFDKYPVLQGGFIWDWVDQAIWVNHEDGNGGHLAYGGEFGEQPHDGNFCGNGLIFADRSVSPKLVEVKKCYQNIDVTAVDLANGVISIRNKSLFTNVDRYTLQWSVAVDGVLLNENTGSLSATAAPGETQEVTLPLPTINEGEAVLTVSFVTQEASAWAEAGHEVAFEQFILPAAEQKAAAVKRKESSGAVQAVETAAAITVSGADFSASFDKVTGSLVSYQVRGAELLKEAVTPNFWRAYTDNDRGNKHHERCATWRSAGEEKVLRELSWDSLPDRVIVQASYLLPTTSASQCTVTYTVSGNGAIEVALQLAPGEGLPEIPEVGMLLVMDSSYDQLEWYGKGPEESYWDRQSGVKLGLYKGKVQEQFVPYLRPQECGNKMAVRRASVTAANGAGLQFTGAPTFELNALSYSPFELEAHDHAHLLPASDKTVVRINYRQMGVGGDDSWGAMPHPQYLLQANRTYSFSFTIQGK
>CP034437.1|AZN39876.1|2153400_2154573_+|FtsX-like-permease-family-protein
MNLSQAFKMAAKSILANKMRSLLTMLGIIIGVAAVIALVGVGQGTTKQVTDQVESLGTNLLTVNITGRGSKTTVDYKEAEEITNKDDIAYSAPVNQQNATVKNGSESTSVSVVGTTADYLDVKEYSLAQGRFVAQIDLDYYQRIAVLGSTTATDLFGSANAVGQSFLINGVRYKVVGVLASKGSSLTGSNDEVVIIPITTSERLFKSKGVKTINVQVAESDKMDQVVTELETALSKKFRGDTDSYRVFNQQDLLDSFSSISDTLSLALGGVAAISLLVGGIGIMNIMLVSVTERTREIGIRKAIGAKKKDILIQFLIEAIALSGLGGLLGVGIGLGTAQVLSKAMSMTVVISVPIIGLAFGFSVFIGVVFGLFPANKASSLRPIEALRFE
>CP034437.1|AZN39875.1|2152709_2153435_+|ABC-transporter-ATP-binding-protein
MEAKPLIQIETLSKQYKMGGETVHALSDISLRINYGDFVAIIGPSGSGKSTLMNVIGCLDAPTEGKYWLDGEEVSRLRESRLAEIRNQKIGFIFQGFNLLNKLTALENVELPLIYRGVPAKQRKEQAIEALTKVGLGERVKHKPSELSGGQQQRVAIARALAGNPPILLADEPTGALDTRTGIEVMELMKELNRQGHTIILITHDIEISKQAKRVVRIQDGQISEVGGERREPQSSLQNGG
>CP034437.1|AZN39874.1|2151270_2152710_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MRKWWVLGIGVVLVAAAVVVYLKMDKKEKPVTQAQATTQVVKGTIDVSVSGTGSLAPVSRETIKGSAQGTVEKVYVKEGDVVKKGDVLLTIEGEDNSDKIKSEQVNLESKKLDLQDIQSKLKSATDENDIASIKLNLKKQQLSIDSSNETIADLEDAQDGDTITAPIAGKITTLSVLEGDSLSPSTELMEIADFDHLQIAVGIDELDIAKVKVGQSATVSVEAISGKTFTGKVTKIADEGTASNGVASFDVTVAIDKPGELKSGMSAEASIEIEKKENTLMLPIDAVQSLGGRYMVILPTGTTGTTTGKGQGAAGTGTGTGQGTGTGKGEAGTGTEKGNAGAGQGAPSGQGQGSFGGRGAASGQGQGGGRTGSRNNFASRLGGTPTMIEVGIHNEDYIEVLSGLKEGDRVVVPTVVTSTTNQQQGFGAGGFGGGFGGFGGGGGTFRAAGGGGGFGGGGGGQRTTSGGGGGGTGGGGGSR
>CP034437.1|AZN39873.1|2150539_2151274_+|hypothetical-protein
MDRSSIKLMAAAMLLSVMLTGCGSKDEGQPANNGQAAVGNVSNSANGSGPVQPDRTADFFAKVVSVSDNTIVVQKSTMKPSDMPGGGGFGGGGGKRPNGNGQKAGGNGNAPSADVQPPADGNQPADGAQPPADGAQGGQNGKAGDGKGRGGNRQGGGRFGGGGFMNQMKFEDAQTSVTADADTKIVSISRGQDGMTTNTLQAADLKAGDVLSVWLASDNTTAQYIMLRFNPADMQGQGKAGNGQ
>CP034437.1|AZN39872.1|2149621_2150395_+|phytanoyl-CoA-dioxygenase-family-protein
MITPQDVDFYNENGYLLVKGVFNKQEIEEMRAAVDKIVDRAARSNMDQNHQWQGDFLPPEELKKLVLKGFHDVQYHDAAFMRAMVHPNMTAVLSQLIGPNVQLHHSKMLVKPPENGAAFPMHQDQPYFPHENHTMLAASVHMDDADIENGCLHVIPGSHKQGPLQHVGRHYLNAKEYPVSEGTPCIAEAGDVLFFNYLTIHGSPANKSERTRRNVLYQYRSATDFPTNREHINWGSGIMVCGENPNFSKARPEFNLV
>CP034437.1|AZN39871.1|2148610_2149489_-|AraC-family-transcriptional-regulator
MFLWNESDTWLNQYALRLKSPEAVFTVHYWGVNEQLTSNFLHKHSFFEICYVLDGRGTYTDDGTSYELRAGTLFCSRPGINHIIQCHPELAIFYVAFELDESSSSDAMRAAFQAMAESSTIVVYDGDDLAAAQLWRSIMRRSGDSPSLPEAVLPQVACSLLLALPGVFVKPLHVEWTAPRRSSSALLKQAKLFITDNLSDDELSLEKVAAQINLSPRHLSRLFSSNVNESYTNYVRKQRVRRAAELLRYSEQSIKEIAEITGFGSVHYFSRTFRSLMNVTPARFRDDSQAHD
>CP034437.1|AZN39870.1|2147756_2148551_+|class-I-SAM-dependent-methyltransferase
MQDNVYTYNYSRWESLARARALFTRPKLDLTPDSAREYLELARLGIDPVGKRVLCLASGGGQQSAAFALLGADVTVFDLSPSQLERDQAAADHYGLTIRTKQGDMRDLSCFEAKSFDLVWQPYSLNFVPDSRVVFEQVSRVLQAEGLYYFMCANPFFAGLTHEAWNGEGYTLKHRYEDERVTSYPDQEWVYDQATAPERIQQPVEYTQTLSRMMNALIKEQFQLAYFGEISSDYPGSEPGDWGHFTSIAPPWIESVWRYSPSVR
>CP034437.1|AZN39879.1|2161197_2161716_-|hypothetical-protein
MKKLQWRWILLILVFAGSLAWVLSLPNTKEWKGQVSSKVRELSQDTLPEFHVTAGDTEDSEIPVTQSTYCWGNRGCADYAWGKMMTRGIEPTSVEAGANIHIRLEDVPVPSELIAQKFLDDNTYETVTLVDGVFKAPSSAGVYHYGVSAYWKTEDGKYSKGDSSVVFVIEVK
>CP034437.1|AZN39880.1|2161912_2162677_+|DUF2087-domain-containing-protein
MNVSESFYNASSTELKQGYAYHADTESYYCLVCGEQFEEGIVYQVDSRFMEAHKAVAVHITKQHGSMLEYLLALDKKLTGLTDLQKELIGAFASGMSDADTVKMTGGGSASTIRNHRFALKEKAKQAKLFLAIMELMDGGLANGQKFVPVHRSAPLVDERYALTRDEYSALLAKYLPQGLAGPLTGLPRKEKRKAALLRHIATAFKKGRKYKETEVNELLKRFMPEEYVTLRRYLVDYEFLARESDGSTYWLNV
>CP034437.1|AZN39881.1|2162745_2163174_+|GIY-YIG-nuclease-family-protein
MTVNRRKELQNEYGMKQRAMGVYQIVNDRNGKRYVAASSTIESAWQREKFTLDMGGHINSELQQEYKEQAGADFRFEELERLKLGEEVRNDYKDTLIPGTNALNRSVVQSYRDSLKKLEQKWLQELQPYIPNGYNKPPKIDQ
>CP034437.1|AZN43624.1|2163222_2164407_+|MFS-transporter
MSNILLQIGIWVRNFSILLYVTDKTNNDPIAVSLISVAEFSPIFLFAFIGGTFADRWRPRRTMIWCDFLSAAAVGVVLLALVYESWAAVYFATFLSATLSQFSAPSSMKLFKRYVPQEQLQSAMGIFQTLMALFMIAGPSIGTIVFQNFGIHVSIAVMGVASLLSALVLIRIPRDEAVTPSADAKQTTVLTEMMAGLRYVWKSRVLRTMCITFLLAGLSGGIGQTMGIFVVTERLGQPKEFLQYVLMISGIGMLIGGAGVAVLSKKMAPVKMLALALAVCTVGTIGVGYSTNVPVTLTLQLFMGMIFPMIHISINTIMLKSSEAAFIGRVSGIMGPMYMGAMVLMMAVAGPLKTVMPLTVIYTISAVFMLAGTISLLPLFKQQPSERPDTSLSA
>CP034437.1|AZN39882.1|2164538_2165657_+|ABC-transporter-substrate-binding-protein
MCLFFFPYDLNSDGGHAHAYENLFYEKSALSAFALIIASSLVLSGCGAKTASTTASAKGSEDALEVKELRYQGSVGAVLFPELAEDLGYLAPLKLKFIGNTISGPQDIQSVVTGDIDFGGAFNGAIVKLLAAKAPIKSVISYYGVDDQTWTGYYVLDGSPIKSAKDLIGKKIAVNTLGAHHEFVIKEYLHRAGLTKDEIDQVTLVVVPPVTSEQTLRAKQIDVAALGGILRDKAEERGGIHPLFKDKDLFGTFSAGSYVLTNKFIKNNPNATRKFVEATAKAIEWARTTPREEVVARFEQIIEKRGRKEDAGAIKFWKSTGVAGKGGLIADKEFQTWIDWLVKEGNLKEGELQAKDLYTNEFNPYKDEANSK
>CP034437.1|AZN43625.1|2165732_2166608_+|ABC-transporter-ATP-binding-protein
MTAKISLQHVRKSFRIQRNLNHLKEELQPVSALQDINLDVRPGEFMVIVGPSGCGKSTLLDLLAGLTKPNSGQILIDGKPITGPNLDRGIVFQQYALFPWKTALANVEFGLEAKGIARKKRGEIARKYIQLVGLAGFEHRYPHELSGGMKQRIAIARSLAYDPEVLLMDEPFAALDAQTRETLQTELLRIWEATKKTIIFITHGIEEAVYLGQRVAVMTSRPGRIKEIIEVPFESRTTEEDLRSNPEFVRIRHQIWDLLKDEVSRAQEQEKNKSLTAASKKTAGKGAGVDG
>CP034437.1|AZN39883.1|2166600_2167491_+|ABC-transporter-permease
MANVSTTTTSTSTRSSGEVIGRYEAGNSASRHLNGSAVLQALRVKAQQWFRNLIVIVAFLALWEIAPRTGLVDNTFFPPLSTVLKAWWQLLLSGDLAEHTEASLSRSLGGFLLALVVSVPIGLAIGWWKPVAAYLNPLLEVMRNTAPLAILPVFILLLGLGETSKISIVFYACFFPLLLNTISGVKNVDPLLIKSAKSMGLSNIALFRKVIIPAAIPTIFIGIRQSGAASILVLVAAEMVGAKSGLGYLIQYTQFSFQIPEMYAGILSISVIGLILNYVILSIERKLTAWRQTYGD
>CP034437.1|AZN39884.1|2167534_2168893_+|LLM-class-flavin-dependent-oxidoreductase
MSKHKKQMNLNVFIMNAGHHEAAWRHPGTEPHNITDISYFQRIAQIAEQAKFDSLFLADGLAVSNNIKHGAFVGLEPFTLLSALAAVTKQIGLIGTVSTTYNEPFHVARKFASLDHISKGRAGWNIVTSGSDFEASNFSSDSHLAHHKRYERANEFLRVTTGLWDSWEDDAIVIDRDAGVFAQPDKVRAIHHEGDTFHVRGPLNIPRSPQGYPVLVQAGSSEDGKEFAAQFAEAIFTAQQTLADAQQFYRDVKARAARHGRNPDELKILPGICAVIGATESEAKEKEQQLNELTVPEYGLTQLSNMLGISLFTYPLDGPLPELPNVSDINGNKSRFQLVADLAGREKLTIRQLIHRLAGGRGHRVFAGTAVQVADQLEEWFTQGGSDGFNVMPPYLPAGLEEFAAQVVPELQRRGLFRTEYQGSTLREHFGLSRPVNQFAAAAVISKNSQII
>CP034437.1|AZN39885.1|2168911_2169874_+|TauD/TfdA-family-dioxygenase
MSQVERNETVEAVEVVEANVNFEVRPVAGRIGAEIRGVELSADLNEETVSFIREALLKHKVIFFRGQHQLDDAGQEAFANLLGSPVAHPTVPIKQGTDYVLELNSAHGGRADSWHTDVTFVDAYPQASILRAVVVPEAGGDTVWANTAAAYDHLPAELQKLVDGLWAVHSNEYDYAAYRSREVDEAAQAKHREVFASTVYETEHPLVRVHPETGERTLVLGHFVKRILGLSSADSAQLFSLLQSHITRLENTVRWRWSEGDVIIWDNRATQHYAVNDYGDQHRVVRRVTIDGDVPVSIDGRHSITRKKVPASPLTTVESA
>CP034437.1|AZN39886.1|2170025_2170763_+|hypothetical-protein
MRIIVPHELVPSHDAVMVSNMIGYGVLLLVAILIWLTGRKSASPEPMLFLKLLVYLVLSVFAFRFNGFALPLGLLIAYLMMRRTKLNRPVKQTAVLFGGMLFLFSLFPLADRIDQLMDPPDQISTYIDRGINPTKQGFNVTVLDNENKLWATLVERDKGVVQLYKELADSRSVETVPVSWEPYYTIELRQDHKQERFRELQLQFDREGRFFTLYNGSTTYSFESTAAFREIFVQQIVPLVRNGEA

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Crispr_ID: CP034437_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_9

3594688-3594932

Orphan

Consensus_repeat	Method
GGCAAAAGCCTCTCTCANNNC	CRT

4 spacers

The CRISPR arrays of CP034437_9

>merge|CP034437|9|3594688-3594932|CRT
GGCAAAAGCCTCTCTCAACACCAAAAACATCGAAAAAACAATCTGAGAGCGGCAAAAGCCTCTCTCACACCAGAACAACCCCATGCTTCGCATCAAAATACCCTCCGAGAGCGGCAAAAGCCTCTCTCAACGACAAAAACACCGAAAAAACAATCTGAGAGAGGACAAAGCCTCTCTCACACCAGAACAACCCCATGCTTCGCATCAATATACCCTCCGAGAGAGGCAAAAGCCTCTCTCACACC

>CP034437|9|3|3594688-3594932|CRT
GGCAAAAGCCTCTCTCAACAC	CAAAAACATCGAAAAAACAATCTGAGAGC
GGCAAAAGCCTCTCTCACACC	AGAACAACCCCATGCTTCGCATCAAAATACCCTCCGAGAGC
GGCAAAAGCCTCTCTCAACGA	CAAAAACACCGAAAAAACAATCTGAGAGA
GGACAAAGCCTCTCTCACACC	AGAACAACCCCATGCTTCGCATCAATATACCCTCCGAGAGA
GGCAAAAGCCTCTCTCACACC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN41077.1\|3585824_3586799_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
CP034437.1\|AZN41090.1\|3605867_3606923_+\|Fe(3+)-siderophore-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182464
CP034437.1\|AZN41085.1\|3597596_3599984_+\|DUF3298-domain-containing-protein	unknown	unknown	gnl\|CDD\|378702
CP034437.1\|AZN41081.1\|3592083_3594555_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379971
CP034437.1\|AZN41084.1\|3596481_3597363_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
CP034437.1\|AZN41082.1\|3595083_3595569_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP034437.1\|AZN41087.1\|3601949_3602759_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378342
CP034437.1\|AZN41083.1\|3595593_3596421_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
CP034437.1\|AZN41075.1\|3582811_3583261_+\|DUF1761-domain-containing-protein	unknown	unknown	gnl\|CDD\|369962
CP034437.1\|AZN41088.1\|3602892_3603891_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224231
CP034437.1\|AZN41079.1\|3587779_3590047_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN43743.1\|3583381_3583708_-\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|235016
CP034437.1\|AZN41076.1\|3584030_3585722_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270298
CP034437.1\|AZN41080.1\|3590054_3591857_-\|alpha-galactosidase	unknown	unknown	gnl\|CDD\|269892
CP034437.1\|AZN41086.1\|3600033_3601770_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377924
CP034437.1\|AZN41073.1\|3580559_3581435_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN41089.1\|3604800_3605862_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
CP034437.1\|AZN41078.1\|3586814_3587684_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
CP034437.1\|AZN41091.1\|3606981_3608028_+\|iron-enterobactin-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182463
CP034437.1\|AZN41074.1\|3581549_3582659_+\|DUF2961-domain-containing-protein	unknown	unknown	gnl\|CDD\|378582

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN41077.1\|3585824_3586799_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	9.77604e-110
CP034437.1\|AZN41090.1\|3605867_3606923_+\|Fe(3+)-siderophore-ABC-transporter-permease	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	4.74986e-93
CP034437.1\|AZN41085.1\|3597596_3599984_+\|DUF3298-domain-containing-protein	gnl\|CDD\|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	7.60905e-20
CP034437.1\|AZN41081.1\|3592083_3594555_+\|hypothetical-protein	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	0.00341041
CP034437.1\|AZN41084.1\|3596481_3597363_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.27215e-100
CP034437.1\|AZN41082.1\|3595083_3595569_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.73344e-19
CP034437.1\|AZN41087.1\|3601949_3602759_+\|hypothetical-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	8.04843e-06
CP034437.1\|AZN41083.1\|3595593_3596421_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	8.16951e-30
CP034437.1\|AZN41075.1\|3582811_3583261_+\|DUF1761-domain-containing-protein	gnl\|CDD\|369962	pfam08570, DUF1761, Protein of unknown function (DUF1761). Family of conserved fungal and bacterial membrane proteins with unknown function.	8.40795e-09
CP034437.1\|AZN41088.1\|3602892_3603891_+\|hypothetical-protein	gnl\|CDD\|224231	COG1312, UxuA, D-mannonate dehydratase [Carbohydrate transport and metabolism].	9.23544e-68
CP034437.1\|AZN41079.1\|3587779_3590047_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.99528e-26
CP034437.1\|AZN43743.1\|3583381_3583708_-\|YnfA-family-protein	gnl\|CDD\|235016	PRK02237, PRK02237, YnfA family protein.	3.00983e-42
CP034437.1\|AZN41076.1\|3584030_3585722_+\|hypothetical-protein	gnl\|CDD\|270298	cd13580, PBP2_AlgQ_like_1, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	3.41675e-63
CP034437.1\|AZN41080.1\|3590054_3591857_-\|alpha-galactosidase	gnl\|CDD\|269892	cd14791, GH36, glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	3.08054e-70
CP034437.1\|AZN41086.1\|3600033_3601770_-\|hypothetical-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	1.43469e-17
CP034437.1\|AZN41073.1\|3580559_3581435_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.37973e-23
CP034437.1\|AZN41089.1\|3604800_3605862_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	8.21922e-61
CP034437.1\|AZN41078.1\|3586814_3587684_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.06365e-62
CP034437.1\|AZN41091.1\|3606981_3608028_+\|iron-enterobactin-ABC-transporter-permease	gnl\|CDD\|182463	PRK10440, PRK10440, iron-enterobactin ABC transporter permease.	1.2158e-104
CP034437.1\|AZN41074.1\|3581549_3582659_+\|DUF2961-domain-containing-protein	gnl\|CDD\|378582	pfam11175, DUF2961, Protein of unknown function (DUF2961). This family of proteins has no known function.	8.08118e-128

>CP034437.1|AZN41081.1|3592083_3594555_+|hypothetical-protein
MNYEVNRGIVESDAGIPETPRWFSDGRLSFQYDGNSVTQVDYRSKYQTRGSHTIFLQRLWDGFRYYLEHDGITLKPKYGKTTVWPCGVESEWKLDGHAAVSHRVFAAGEAIVFQVTTGAELPEGYKFKLEFYKDFGLITDDLQDLRYGDRGSKRHWRDFEFHADSNVLLGSMMDVPREQPVKGSEVNLNNMDIEREEDSTPNELFVAVGADFQLQFQERSIHTKYILTSQIALVPNRSYSFVIGFAHTEKLVIETVGRLSADVGKVLEGQLRRYEQVRHTSPVLISPYKKLNDFISLAPMYHESCKVLETPGAIKAKNTNYWVWGWDGMTSNLASLYWGDQLFIRDMLRFYEETADAEHGIGHSFRHDMSLASVSALPAQSMYITLLHQYYTITGDVGELRSRFPFAKSVYERILKMEVQGLGLSKGASLFPDFPMYMQETGEDISSLNNTIFYCASRSMEMIAELLGEQETRELADKVNRNIEKHYLPLFFDAQRGFVVSSVDTVTLERRSSYNSNAVKWENFFCGELMMGVNEQALRFFEQHIVCKAGLREIPVWSDAFDRDANQLHCWWPVTGEYYMQLINGQSKRELIDQWVGWVSYWTNKLTCPEGISCYLDTDEPEVDRWNTTKGTWHAYSIRGWYQAAMHGVVGVGMEAGGLTFYPYDGEEMRLEGLHYRGWRFNVEMRGSGRYVEAIEVDGKRVCGTNKLPEDVYGAGADEVDVDVNVVVHRTVERVYSVSVKHGYGISMTGYSCEQGEIRAELQGAGLCRLVLEADHMPMVYLNDTAAKVAYDKAAGVATVELRMNAVERGRLVVNAAANWNLS
>CP034437.1|AZN41080.1|3590054_3591857_-|alpha-galactosidase
MLVEAAGLFQYSLENNATTEDPFRVELTVEPSNEPGIELVHIRIHSDIASVPAPIHLKWRLPIVDVQGQWHPTAIYNKGLRADWSQPFESKSTYSAPVFCLFGGDGGNRLTFAFSDVLNVIKYDAGINEETACFHCHITMFDTPTTPICNYEATLRIDTRSHIPYYEALQQVSDWWSTFAENKPAPIPDAATQPMYSTWYSFHQNLSPEAIEEECAAARKLGCETVIVDDGWQTADNARGYAYCGDWQVCTEKIPDMRAHVANVHKLGMKYILWYSVPFIGKKSEAWGRYQNKLLYTIDSLEAGVLDPRYPEVRRYLIEVYENALLDWDLDGFKLDFVDVFGQPEKENPGNADGRDDISVAQAVDLLLSEVIKRLSVIKPDIMLEFRQNYISPLMRKYGNLFRAADCPNDAIQNRMRTLDIRLLCGNTAAHADMIMWHADEPVESAALQLINVLFAVPQISVRLTTLPEQHAEMVAFWLAFWKEHRSTLLEGKLAPNHPELLYPLVTANDSNTYIAAVYQENLIIKLPDSQPLPPQTILINGTRSDRLIIERTHQPIAAAATVTIKNCLGQTVNEYALSSTQGIQAIPVPAGGLAIISAS
>CP034437.1|AZN41079.1|3587779_3590047_+|AraC-family-transcriptional-regulator
MKLGFRWFQNIYAKLLLILLCIAIIPSLISSVFSYQISIKNAKQQSENYSEQLLAQIASANDITYEQMRSFIYEIMINFSYYSDVMEKTPYSAAFLDVRTALDRKRQAYQKHIKNFSIIDLASKKVITSVGGISIYGMDEYRDQVDKNLMEMVTKKDDSLQSNELVLRPTGDNQKVLTYIFKYGPAAAVKGFIAVDVDASSITHPVQAGGYGSLFVRNSKGLMLSDQNLSLFQASQDPSTKSDYVVISQKSTSSGLQYDYVIPKHALTKSSDRVLNSILFISLSLVVLGALAAWMSSKNIYTPLRNLLGYIRGLTGDTLTAAPNMNEINYLEQAFTRMDQENKSYLNMIRSNQNVFKQRQLALLLTGDIAGYQSLEVPSKLRLQWPHDRFLVMTVEIEDVSAFKAKYTQLEQQLLYFAVENITEEVLGEQGAAVAGHLEPYRLSVVFNYSSDRTDHEQTIELCKQLKQQIVGYLHLSVSIGISEAASAVEEIKLCYDQSIRAISYNVYFGKSSIIHYPSVAQMDNHLMFDSNSIQWNEVKEQIKIHFRMNEWDRIEASLTEMIHKVSYIGITKSDVQYIFLQYVACLSDLCVEFSLQLSDVFGKHFYINESAATLSTMEELKLQMTTMAKRLYEKLGEKKTHIHTEMIEQLLHYIEEHIEENITLESIAEKVYMHPAYLSRICKTVTGLSLGEQIVLAKINKAKSLLVHSDDKVGDISERLGYTTPRAFYRIFKDYTGFTPSDFRKREGLKSITE
>CP034437.1|AZN41078.1|3586814_3587684_+|carbohydrate-ABC-transporter-permease
MLNKKMNVFDYLNYLFMTLLCLTMIYPFLHTFSLSFSDPIEASKGGFMFWPRGFQLDTYKGLLKDSLFWRSYLNIVAVTAIGVAVCLFLTSCASYVLSLPHYPFRRFFTMFIVFTMFFSGGIIPSYLLTKDLHLMNTWIPLWIPGVIAAFNIILLINFFKQIPSEVREAAVIDGASDFAIFTRIVLPLSKPVLATVGLFLAVMFWNDWFTPYLYLNDTDKYTLPLILKKYVVNSEIDGLSGFVKATNQQVLPSQVRSTVILVGILPTLVIYPFIQKYFVKGVTLGSLKG
>CP034437.1|AZN41077.1|3585824_3586799_+|sugar-ABC-transporter-permease
MDIAKEYRAAPKVKAIRSKPTFLQSLRSLVKHWQLSLMLLPVVAAFLIFSYFPLLWLLIAFKDYNIGKGLWGSPWVGWKHFHMIFTYPDMLQLIRNTVFISLLNLGFGFPAAILFALLLNEIKHSAFKRTVQTLTYLPYFIPWTIMAGFILLMFSIDGLINNVLVDYFGLDPKNFLTNNTSFIQLLIGSAIWKGMGWSSIIYLAAIAGVNPQLYEAAHIDGASRLQRIVSITIPSIAPVIGITFILQVGGLMSSNFDQIYNMYNAQVYKVADVIDTFVVRMGVTQMQYSITTAMGLFKGVVGFILIILSNYIIRKTSDSENSLW
>CP034437.1|AZN41076.1|3584030_3585722_+|hypothetical-protein
MLRNSNHVKRTRVNKKVSVIVMAILILALVGCSSNSNNNTSTNNTASSNKQTNDSTNATTNDSKTTNDTAATTDNSTATTTEPPMEINWHGNFQLDSLLPDSYVQKIIEEKFNVKINFVSAKMDKLNLLAASGDLPDVMRIADPKDVAALGSSGVLLELPKDLLSKEMPDVTSSIDQVDPGLWGLTNVSGTNYAIPQYLAVVPWDTGMAWRKDVLADAGITTVPQSIADYDSAFKTIKSKEKDILKATKATSKKLYMFSGADIQYPWNAYTWLFGAYNSMPGTWQLDASGNIARGETLPGTRDALVKLAEWYKDGYIDPAFVTDKGDQMDAKYAQGAYAMTTKGIDGITSPNPDSLQKVNPDVQYDFTKAPTGANGEQGVWSWGKRQNFIAFSAKLKDQPEKVNKILEIMNAVATDDSLFLTTHYGEEGKSYKLDNGIPVVIPPYDNDKSPESNALGTGGPNGGLFGPFGSIDIVKKFTNPQMVDAWQTYYAGKPDVLFMLPLPSTASTDQRIQDKWNETFIKIVIGEAPISAYDDFLKWFDANGGKQLTKEANDLYTASFKK
>CP034437.1|AZN43743.1|3583381_3583708_-|YnfA-family-protein
MLLAIAIFLLAGLAEIGGGYLVWQWLRESRPWTFGLAGSLILVLYGIIPTWQSFPSFGRVYAAYGGVFIILAVLWGWLVDKKSPDFYDWLGAGICIIGVSVMLWAPRA
>CP034437.1|AZN41075.1|3582811_3583261_+|DUF1761-domain-containing-protein
MLSTINYGAVAVTGVLSLVLGFLWMAVIWKKPYQRDMYGNTVDRTATPKPSKAGMIQSFVLYIVVSFVTSIAYAVCLELFRSGGQAFDYDGDSFANAFWFTMLLTAGFTLPFTVGKKVWQFKSWTVVAVDTSYEVVRFTMLLLFFWYWT
>CP034437.1|AZN41074.1|3581549_3582659_+|DUF2961-domain-containing-protein
MGMLQNNGLGLGLASAPLVTNARTRSISAENPKGEKGQGGKEASNLGTARKGRPCITLKQGEIATLVDIQGAGIIQHFWITVTDKTGKGHAQQFVLRDLVLRMFWDDEATPSVEVPLGDFFCNGFGVRTNVNSLPISVVPTGGMNCYIPMPFRKSAKITIENQHAVDIDGFFYTFNYSLVDELPDNAAYFHAQWRREHVTEVAQDYTILDNVKGAGQYIGTYLAWAALERNWWGEGEIKFFMDGDEEWPTICGTGTEDYVGGAWCFNNMTTNEPESYSTPYLGYKFYKETTEIDAWYGHNVPMHGMYRWHMLDPIRFESDLRVTIQQIGHDHTKLFERADDISSVAYWYQMEPHTPFPQLLPTNKRWPR
>CP034437.1|AZN41073.1|3580559_3581435_-|AraC-family-transcriptional-regulator
MTLRIEKLSPYIRVAIDSVLDETWTVEERVIWDYELLYLMEGQLLVTVEDHVYHGTAGDFFFFKPGQRHSIRNVGGTRVRQPHVHFDLYTDTISSEIGVSFKKPEAMTAKERSWMRVNELNSPPYYIPSYFRPRDALPITQSLFELIREFETKPPFYELRMKGALLNILAQMMREQYWGSMTSSDGHMELLAEVRSYIDQNAHRMVKLDELSERFHLSKFYLINLFKTMFQMTPIQYHQHIRIEKAKNMIQYTHLSMQDIADQLGYANIHAFSRAFKSSAGSCPSDYRRGR
>CP034437.1|AZN41082.1|3595083_3595569_+|GNAT-family-N-acetyltransferase
MLHIRPMLLSELDFLMDMHYESIHIPQNKPPKDELLNAPAIRKYNESWGRAGDAALLAEWEGQLVGAVWLRLFNEDNKSYGYVDAETPELGIAIAPGHRGRGIGLALMKEIIELARADGYRALSLSVDPANSSAVHLYERLGFVRCEVAEGTSWTMKLNLV
>CP034437.1|AZN41083.1|3595593_3596421_+|NAD(P)-dependent-oxidoreductase
MKILITGATGSVGTGVLEALTQQHDIRLSDIATPSGASPQPFFAADVREPHALDEAAQGVDVIIHTPAYHGIHMGTFTEKEFYDLNVTGTFEMFQTAVRNNVRRVVWLSSMSFFGDDFYAYTKKLGEQLCEFYHRKHGIEVIMLRPADFTPFRSRAHYGERLLHGGVDRRDVIQAVVKATTCEQQFGAYHIVREDQFTEADIAAYEQGKRAETWERLYPGAQALIEKYGFHLPATIHPVDLSREKQELGYTPNYNLGTFLEEFTRDNTIVEAENK
>CP034437.1|AZN41084.1|3596481_3597363_-|cation-transporter
MDLLNKKAEYGAWISIGVYIVLSLLKIGAGWWGNSEALLADGLNNTSDIFASLAVLIGLRISNKPADADHQYGHSRAETIASMVASFVMFGAGIEVFRSAFAKIMEKEIALPDMFAAWVAVFSAVVMYLVYRYNSRLAQRTQSHALKAAALDNRSDAFVSLGTFIGVIGAINGLPWLDAATAIIVGLVIWKTAWDIFREATHMLTDGFDENELEKYKETVLSLNGVEGVKDIKGRVHGNQIFVDVVIEVDHEMNVLESHEITEHVESELLEKHQVMQVHVHIEPYMQNERLSK
>CP034437.1|AZN41085.1|3597596_3599984_+|DUF3298-domain-containing-protein
MTPYNEQLIQFASAFLPYGAELEFIESTIPRAAICAVDMNEDYIPETVLVFRLQGELHLLELRCTNGVWERATGLKAPGYGVTLMTAMPITRTGANNLVVGWQVSPDYSKLSIYEWTDNGLVDVAPEDMYYSYLESLPVTRTDESDEGTCCLALWSHESGEAYRVDVVKWNGDTFEEAPDAYSDYYPNIARYYEQLTRRYPSAPIYWEYLADAQFRVSMSRAVALYPASIKRVGGTKWGYINSNGRMEIPVRFDDANDFQKNGLAVVTEKGRTGLINASGQYVVQPIYDSIYPFSEKRAAVIDKEGFHMINESGQVLTKRAYPYIADMRGGRSLFYITKDHADGSSQSLYGYLDANGNEVIPAQYEDATDFTSGRAVVKIKENVYALINSSGKRLATYPFAYVGPYGDGMLSFQRELSGKYGYIDEGGKIIIQPTYYAAMPFERGRAVVNTSADFHSEYGVINKKGSFIVEPIYNDVRSLGEERFALGNAIDKEQPYIGSVYAIADWNGKRLSDFLYNDVSEYQSGLASVSDTKQTYFIDRSGKPAPGYPRVQGRGTLTVEEGGLIKAFVDQRLSYRNRAGRMIWQQNVVIPLAPPYAVKEVKFNPNPDYLVYYPQVDGMADQAAMRNVNTKLKEMSQVKPIPANERLDYSYTGDFDVSFFKHQLLQLELTGYNFPFGAAHGMPSQIYAILNLVSGHMFALKDLFKPGSDYVKVLSDIVGKQIKEDPQYSYVFPDTYKGISPDQPFFVTENALHLYFNPYDIGPYAAGFPTFTIPFAEIRSIINTNGEFWRSFHP
>CP034437.1|AZN41086.1|3600033_3601770_-|hypothetical-protein
MKISLKPRRTMLCALAALSILIPTAGVGTGATAHAEGVQLNTYPSYLEKTPVTKPIWTAPIDHEQYMPSGSSYVVEGNIIVYMKNKHLVSADIATGNAYWSSKTNFTNTFFLHGGVLYALGEDRVLYAFNSQYGTKLWMSPLGKTNLVQMKFDDKRIYASFNEALFALDPATGKKLWMVDKTEASAIDDLTLVGNTVVQSYIEQGAISHDNLYGYDAATGKEKFGFGWSSSPLEVEGNMMWVKSYNFMAEDPLTTHVLQINTDTGKLIKDQVYDVSKINAEISTSSPNDPYTRITKLAMDGPWIYIGVNDVVYRYHRDADPTKGPPFVYNHLFQGTLGKWILGPSDGYMQFEGVVGLTSLSMFDLTKPNINYWGYGNISRVDRIGGGMFIGLQNGHFIISQLSTGKTLLHGQTSAWMFNKFTVAGNIVFVQAEHQLLAYPLPAAAKFAPTHKLIIKDEKADIVVDGVKHAISPDAAFVNNQVFVPFRAMFALFNGTISYDAASKSVTASALGKKIQLTAENALVTLDGSKIGLSEAPLMYHNTVYVPLRDISTMLGTSVTWKNHTVYISTKPEEAAAK
>CP034437.1|AZN41087.1|3601949_3602759_+|hypothetical-protein
MSEGSERIRIVRIGLITGGILLVLALLLVLMLKMLNSHESRHVARFPAHDYQYMEREAASGFKLHVLQTDPSNISLEVVRQNLALSDYYGVNGGFFYDTSLVSMAIVNGQPVGGAKGQYGTGDENTKYARGTLVWDGASNKLSVQIVSKSSELKVSDPLHYWAQGGISMSLGQDELWYGRAVLENAPLMDNDHLRSAAVYDRQGKLYLIVSSTSGTLADFRAAILDQLGSLQLVDGIFLDGDGSSQMQAAEKVLKGDSRPVVEMIRIVK
>CP034437.1|AZN41088.1|3602892_3603891_+|hypothetical-protein
MKQNIRIALGQMQELTHETMTYARQLGVSSVQLNTPNIPGEACWSYEDLYAIKKTCDDNGLFLESIENVPIRFYDKIMLGLPGRDEQIENYRTIIRHMGRAGIPVLGHHFMPNFVWRTSSEPGRGGALCTAFDLEAAASGINQVKYAANREVRIPDESVMWDNYAYFLNAVIPVAEEAGVRLALHPDDPPVAMLDGTARIFYKVENFKRAEAIADSEAWGLNLCLGCCSEMVYGAANVMEMIRYFGPRNKICYVHFRDVQGTMPKFQECFLGEGNYHPAEVLLELKRSGFTGFLMDDHVPSVINDSPWGHRARAHAVGYMQGLLNALELIER
>CP034437.1|AZN41089.1|3604800_3605862_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MFKSIKMQKWVGSVTVVAAVAVGLMGCSSNNNGNEQGTTGNSNKAANSATDTATNTANNTTTKFDATVDTKFGQIHITEQPKRIVALGWGDAETALSLGVEPIGASDWLAFGGEGVGPWMKGAYKTAPKILGTTELDYEQIAALKPDLILDTKSSGDDARYKRLSEIATTVGVPADGDSYLTSTNEQVEMIAKALGKENEGEALLKQVDDAFAKAASENPEFANKSVVVAAYSSDGFGAYVKGDARVDFMTRLGFKNKEAVEKLANGNFYIKVSDEQLDLLDADATVVMPIWIDPKEITNNKLFQKIPSVVDGRSIILDTDTANAFSTGTVPSLLWTIDHLPAQIKALVKAGA
>CP034437.1|AZN41090.1|3605867_3606923_+|Fe(3+)-siderophore-ABC-transporter-permease
MTLAKQPANDRGQAQTISSMQTKRITGFIIALILLAAAVCLSLMIGAKRLSIETVWQALFSNTDSYEHRVILDSRLPRTLLALAVGPAFGLAGALIQALTRNPLADPGILGVSAGAAFAVAIGVGVFSVGTLSGYVGFALVGAMAATIIVYIIGGGAGKKAPTPIQLTLAGVALGAALSGITTAMTLMNSEAFSRMLNWTVGTLTRKSIGDIWIVLPLLVIGAIAALIISPALNAIAFGEDRASSLGVNITLIRIVGLIAITLLAGGATAIAGPIGFLGLMVPHCVRWFVGPSQPWIFLYSLAIAPLLLLVADVIGRVVISPTEVPVGIIMGFIGAPILIILVRRRSASKL
>CP034437.1|AZN41091.1|3606981_3608028_+|iron-enterobactin-ABC-transporter-permease
MPPIHFGRRYIRTRRFMKLRVDAKSFSIATALLIAALALALYGLMSGTMSLSIHEVFSAFSGDAAKMTRTVVIEWRLPRVIAAIVFGAGLSVSGAIFQSITRNPLGSPDIIGFTSGSYTGALIAMLMVGSTSFIGIAGGALIGGFATAVLIYLLAFRKGTHGFRLIIVGVAASTILSSLNAVLLLRSKAEVALTAAAWGVGSLNGISWSQSTPAMLAVILFLLFAAMSGRSLRAMELGDDAAKAHGINVERSRILLILIAVVLTAAPTAVMGPVSFIALAAPQIALRLTKSAQSFGPVAMMGAFLMLASDLVAQRIVPGTILPVGVVTLSLGGLYLVGVLFRQARRAS

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Crispr_ID: CP034437_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_11

4844573-4844727

Orphan

Consensus_repeat	Method
TTGGAGCGACTGCGTCACTCCTAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of CP034437_11

>merge|CP034437|11|4844573-4844727|CRISPRCasFinder
GAGGAGCGGCTGCGCCACTCCCGGTAATCTGGGGGCCGCCTAGTATTCCTGGCGGATATGTTAGTTGGTAAACCTTTTGGAGCGGCTACGCCACTCCTACCAAATTGGAGCGACTGCGTCACTCCTACCAATTAGAGCGGCTGCGCCACTCCAAA

>CP034437|11|6|4844573-4844727|CRISPRCasFinder
GAGGAGCGGCTGCGCCACTCCCGG	TAATCTGGGGGCCGCCTAGTATTCCTGGCGGATATGTTAGTTGGTAAACCTT
TTGGAGCGGCTACGCCACTCCTAC	CAAATTGGAGCGACTGCGTCACTCCTACCAA
TTAGAGCGGCTGCGCCACTCCAAA

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN42080.1\|4840860_4841121_-\|DUF370-domain-containing-protein	unknown	unknown	gnl\|CDD\|179823
CP034437.1\|AZN42082.1\|4844781_4845480_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
CP034437.1\|AZN42073.1\|4831984_4833031_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|237717
CP034437.1\|AZN43846.1\|4854406_4854895_-\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|377611
CP034437.1\|AZN42075.1\|4835615_4836104_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
CP034437.1\|AZN42078.1\|4840005_4840215_-\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
CP034437.1\|AZN42084.1\|4846746_4849542_-\|calcium-translocating-P-type-ATPase,-SERCA-type	unknown	unknown	gnl\|CDD\|223550
CP034437.1\|AZN42088.1\|4853493_4853931_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42079.1\|4840228_4840846_-\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
CP034437.1\|AZN42085.1\|4849697_4851551_+\|fibronectin/fibrinogen-binding-protein	unknown	unknown	gnl\|CDD\|336217
CP034437.1\|AZN42076.1\|4836133_4838656_-\|primosomal-protein-N'	unknown	unknown	gnl\|CDD\|235514
CP034437.1\|AZN42086.1\|4851613_4852462_-\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
CP034437.1\|AZN43845.1\|4833167_4834628_-\|16S-rRNA-(cytosine(967)-C(5))-methyltransferase-RsmB	unknown	unknown	gnl\|CDD\|237857
CP034437.1\|AZN42090.1\|4855036_4856851_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42081.1\|4841430_4843293_-\|bifunctional-homocysteine-S-methyltransferase/methylenetetrahydrofolate-reductase	unknown	unknown	gnl\|CDD\|236321
CP034437.1\|AZN42089.1\|4854113_4854377_-\|DUF2129-domain-containing-protein	unknown	unknown	gnl\|CDD\|378299
CP034437.1\|AZN42077.1\|4838652_4839876_-\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513
CP034437.1\|AZN42074.1\|4834666_4835611_-\|methionyl-tRNA-formyltransferase	unknown	unknown	gnl\|CDD\|234567
CP034437.1\|AZN42083.1\|4845561_4846590_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
CP034437.1\|AZN42087.1\|4852452_4853364_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN42080.1\|4840860_4841121_-\|DUF370-domain-containing-protein	gnl\|CDD\|179823	PRK04323, PRK04323, hypothetical protein; Provisional.	8.42997e-53
CP034437.1\|AZN42082.1\|4844781_4845480_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	6.7177e-20
CP034437.1\|AZN42073.1\|4831984_4833031_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|237717	PRK14455, PRK14455, ribosomal RNA large subunit methyltransferase N; Provisional.	0
CP034437.1\|AZN43846.1\|4854406_4854895_-\|YlbF-family-regulator	gnl\|CDD\|377611	pfam06133, Com_YlbF, Control of competence regulator ComK, YlbF/YmcA. YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, pfam04468, interact directly with one another forming a stable ternary complex, in vitro. All three proteins are required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated form of Spo0A, as Spo0A-P.	4.06205e-17
CP034437.1\|AZN42075.1\|4835615_4836104_-\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	7.17871e-77
CP034437.1\|AZN42078.1\|4840005_4840215_-\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	4.16568e-17
CP034437.1\|AZN42084.1\|4846746_4849542_-\|calcium-translocating-P-type-ATPase,-SERCA-type	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
CP034437.1\|AZN42089.1\|4854113_4854377_-\|DUF2129-domain-containing-protein	gnl\|CDD\|378299	pfam09902, DUF2129, Uncharacterized protein conserved in bacteria (DUF2129). This domain, found in various hypothetical prokaryotic proteins, has no known function. Structural modelling suggests this domain may bind nucleic acids.	2.02488e-30
CP034437.1\|AZN42079.1\|4840228_4840846_-\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	8.32174e-114
CP034437.1\|AZN42085.1\|4849697_4851551_+\|fibronectin/fibrinogen-binding-protein	gnl\|CDD\|336217	pfam05833, FbpA, Fibronectin-binding protein A N-terminus (FbpA). This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host.	0
CP034437.1\|AZN42076.1\|4836133_4838656_-\|primosomal-protein-N'	gnl\|CDD\|235514	PRK05580, PRK05580, primosome assembly protein PriA; Validated.	0
CP034437.1\|AZN42086.1\|4851613_4852462_-\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	6.37093e-52
CP034437.1\|AZN43845.1\|4833167_4834628_-\|16S-rRNA-(cytosine(967)-C(5))-methyltransferase-RsmB	gnl\|CDD\|237857	PRK14902, PRK14902, 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB.	0
CP034437.1\|AZN42081.1\|4841430_4843293_-\|bifunctional-homocysteine-S-methyltransferase/methylenetetrahydrofolate-reductase	gnl\|CDD\|236321	PRK08645, PRK08645, bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed.	0
CP034437.1\|AZN42077.1\|4838652_4839876_-\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
CP034437.1\|AZN42074.1\|4834666_4835611_-\|methionyl-tRNA-formyltransferase	gnl\|CDD\|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	2.27574e-175
CP034437.1\|AZN42083.1\|4845561_4846590_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	2.07813e-26
CP034437.1\|AZN42087.1\|4852452_4853364_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.82265e-87

>CP034437.1|AZN42081.1|4841430_4843293_-|bifunctional-homocysteine-S-methyltransferase/methylenetetrahydrofolate-reductase
MKPDFREALAKRILTGDGAMGTYLYGMGFPVGVSYEEFNLIRPHVIEDVHRRYYEAGARVIETNTFSANLASLSHYGLDSEVEAINRAGVRIARAAVGADAYVVGAVGSIRAGKRKNISEAQLEQLFRQQMDALLQEGADGLLLETFYDLEEALLALRIARSLSDLPVITQFAVEKDAVTQDGVPLASAFEQLKQAGADVVGFNCRSGPNGILRAIDAIVGDIPLPLSVFPNAGIPDYVDGKYSFTASPEYFAESAKKFADRGARIIGGCCGTTPEHIAAIAAALNGYTPQQTTDTRETAPAVQTETIQIKESFTPPAQTEPNIVDLVKERHTVIVELDPPRDLDIQKFMAGAKALAEVKADAVTMADNSLAVTRMSNIALAALVGQQAGIRPLVHIACRDRNLIGTQSHMMGLDALGIDHVLAVTGDPARFGDLPDSSSVYDLTSFEMIRMIKQLNEGIAFSGKPLKQKAKFVTGAAFNPNVKYLDKAIQRLEKKIESGADYIMTQPVYDKELIIRVAEATKHLSVPVFIGIMPLASGRNAEYLHNEVPGIQLSDEVRKRMAGLEGETGRAEGVRIAEELLDTALEHFNGIYLITPFMFYEMTVKLTDYVWRKTSKLTR
>CP034437.1|AZN42080.1|4840860_4841121_-|DUF370-domain-containing-protein
MAIKLINIGFGNIVSANRIISIVSPESAPIKRIIQEARDRHMLIDATYGRRTRAVIITDSDHVILSAVQPETVAHRLSTKDDDHDE
>CP034437.1|AZN42079.1|4840228_4840846_-|guanylate-kinase
MKRGLLIVLSGPSGVGKGTVCAELRHKQSDLIYSVSATTRSPRQGETDGINYFFKTKEQFQEMIAKDALLEFAEYVGNYYGTPRDFVERTLASGKDIILEIEVQGALKVKEKFPQGVFIFLVPPSLDELKQRITGRGTENADIIDHRMNVAVEEMNLIHYYDYAVVNDQIDAACHRIHCIIEAEHCRKERFIEQLEEVKEASEKA
>CP034437.1|AZN42078.1|4840005_4840215_-|DNA-directed-RNA-polymerase-subunit-omega
MLYPSIDEMMKKVDSKYSLVVAASRRARMLRDGTKTDIRSPRSHKFVGVALEEIYQDILVVESTLNKKD
>CP034437.1|AZN42077.1|4838652_4839876_-|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MLQGKTIVLGISGGIAAYKAATICSRLVQAGAQVRVIMTESATKFITPLTLQTLSRHQVYLDTFNEFDPSVVAHINVADSADLVVIAPATANILAKMANGLADDMLSTTLLATTAPIMVAPAMNVHMYEHPAVKRNMDILAERGVRYIEPGTGLLACGYVGKGRLAEPEDIVFAVQQWFAQSRELEGKKVLVTAGGTMERLDPVRYLTNDSSGKMGFALAEAAANRGADVTLIAARTTAAPVAGVNTVHVESAEEMLEAVLERYESADLVIKAAAVADYRPVVKASTKIKKGNEKLVLELERTTDILQTLGERKKHQFLVGFAAETEQLAHYAMDKLRRKNCDLIVGNDVSQAGAGFNVDTNIVQIFGEEGLVESLPVLSKREVADRLLTQIVQRMKAAPGAKGAAE
>CP034437.1|AZN42076.1|4836133_4838656_-|primosomal-protein-N'
MIAKVIVDVPSRATDRPFDYKIPQQLQGWVEVGSRVGVPFGGRVLQGFVVGIADQADVDVMKLKPIAELLDHIPPLSPDLVELASWISDKYCCTMTAALQVMIPAALKGKADSVVTLVEEELENSLIGEEAWLQYIRQNSGSMRMAALQERFPDDAAAIKAAVKEGLLSEQVTIRDRLSVRKVLTVFPPDNEALALEALHNYPARAAKQQEVLRYMLEHKEPVAMTALVEALSTTSSTVRAVADKGLLEIREMEQNRDPYAGRNFKRTEPLPLTEGQQAVYEEIAESLDAEQSRVFLLHGVTGSGKTEVYLQTIERSLQHERQAIVLVPEISLTPQMVERFKGRFGDLVAVLHSRLSNGERYDEWRKIREGRAKVAVGARSAIFAPFDRIGLIIIDEEHESSYKQEETPKYHARDVAVRRARQHGAAVVLGSATPSLESFAAASRIVSAGSESTGAAAARAAGGAALLPMPSRVGGRPMPKVHLIDMRDELKNGNRSMFSRQLHEALLDRLERGEQSVLLLNRRGYSTFVMCRSCGYTAQCPHCDISLTYHQKSRVLRCHYCGHAEQAPEKCPSCESEHIRFFGTGTQRVEEELAKLFPGIRVIRMDVDTTTEKGSHEKWLTMFGERKADVLLGTQMVAKGLDFPYVTLVGVIAADTSLHLPDFRAAEKTFQLLTQVAGRAGRHELPGEVVVQTYNPEHYAIVSAQHHDYAAFVQEELKHRRFMGYPPFCRLIVVTLSDEQLPLLITTGEKLASALRQLAYESGIKGSMDSDGTRFIDILGPVASPIPRMKDRYRFQCMVKYRGNVNANELLKQAISMLPGPQGQPPVQISVDVDPQMIL
>CP034437.1|AZN42075.1|4835615_4836104_-|peptide-deformylase
MAIRLIVQDPDPVLREKAITVTKFNSNLHKLLNDMAETMYDADGVGLAAPQVGISKRVIVVDVGDDNGLIEMVNPEIIEASGEQLGPEGCLSIAKLNGDVKRAQTIKLKGQDRDGNPFEFEATDFLARAFQHEVDHLNGILFTDIAVSIYDASARQRQDDGE
>CP034437.1|AZN42074.1|4834666_4835611_-|methionyl-tRNA-formyltransferase
MRIVFMGTPEFAVPSLEAILEEGHTVELVVTQPDRPKGRKKTLTPPPVKDAALLRGLPVAQPERLRKSDTVDQIAAIKPDLIVTAAYGQILPKAVLDIPRLGCINVHGSLLPKYRGGAPIQRSIINGETVTGVTIMYMAEGLDTGDMISVVEVPITEEDTSGTLFEKLTIAGAQLLRETLPSIEAGTVQAVPQNHDEASYSPNLTREDERIDWSRPARAIYNQVRGLSPMAGGFTIWNSEPFKVWGCKPVIQSQSKAEPGTVLETTDAGILVQTGEDALLLTVIQPAGKKAMNAVEWLKGARLEAGTVFGGGEA
>CP034437.1|AZN43845.1|4833167_4834628_-|16S-rRNA-(cytosine(967)-C(5))-methyltransferase-RsmB
MKSRGGGNTGTSRGNRNKKPQQKQQQQPQRKKTAREVALDTLVKVAEAGAYSNLQLNRALQDAQLSRQDAGLATELVYGTIQHQRLLDERLSELVTKGFNKLTPWVLVLLRMSAYQLLMLDRIPPHAAVNEAVVIAKRRGHSGISGMINGVLRNMERSLAELKKPLVIADPVKRIGITYSYPDWLVKRWIGSYGEAVTEQICAAGNEPPHSSVRVNPLRLSRDKASTMLAEASGGEASVEASRLSEHALIVSGAGNLAGTEGYRTGLWSLQDESSMLVAEVCAPKPGMKVLDCCAAPGGKTTHLAELMEDRGQVIANDVHPHKKQLIEEQATRLGLTSIQAVTGDAAELASKFEPNSFDVVLLDAPCSGFGVIRRKPEIKWTKSAEDVLSIAALQEQLMDEAAKLVRPGGTLVYSTCTIEREENEHQVAKFLERHSEFKLDAKWPAQVLRPLQEAHAIAEPFSGMVQLLPQQFGSDGFFIARLTRQ
>CP034437.1|AZN42073.1|4831984_4833031_-|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MKPIIYDYTLEQIQDWMKENGESAFRGTQVFEWLYVKRVKSFEEMSNLSKGLRQKLDENFQFVTLTEITRFESKDGTIKFLFGLHDNHAIETVIMRHSYGNSICVTTQVGCRIGCTFCASTLGGLKRNLTAGEIVAQVVVAQQLLDATNERVSSIVIMGSGEPFENYDATMTFLRLMIHEKGLNIGQRHITVSTSGIVPSMYKFAEENTQINLAISIHAPNDKLRSKLMPVNRRFPFEEVMEACRNYIAKTGRRITFEYALIGGVNDQSEHAEELAQVLKGMLCHVNLIPVNHVPERDYVRTPREQIFEFHRILEKNKINATIRREQGHDIAAACGQLRAKHMESTAG
>CP034437.1|AZN42082.1|4844781_4845480_-|class-I-SAM-dependent-methyltransferase
MPNHDQIYRSEAERYDRLVSREDVNNNLMETIRKVCPDLSDLHAADLGAGTGRLTMMLAPRVRSIVAMDSSEAMLEVAAGKLRGLGAENWLTKVGYHDSMPLPNQSIDLLTAGWTICYSTSSNNADWQEQLARIMDEIRRVLRPGGTVIIFENFGTGTEQPSPPDFLTSYYSALEQQYGFLHAAIRTDYQFESVEEAIALTSFFFGDEISSAVAASGNTTVPEWTGVWWKRF
>CP034437.1|AZN42083.1|4845561_4846590_-|MerR-family-transcriptional-regulator
MKINELAHKLHITPRAIRLYEAKGLLSPARGEENGYRYYSDHDAWRLQTIASLREMGLSLEQIKVLMEKLDQGDSASVHHYLELQRMALYEKWTKWKHVIGTLDELIERLETKQTLLLDDLFQLSGELQHTHESVSTWKDTWDFDRIAPGFDGSPAILSSGSLLTQSEYEMVLDFIVQWVAPKQGEDGLDIGTGTGNLAGKLQLSGASMSAVDQSKEMLSRCREKFPAIATKLGNALALPYVDKQFSFLVSAFALHHLEASKQQELALEEMDRVLKPSGRICIAGLMYEGGADGVTYTHDELNGKHPIDRAKLLGWFYEHDYITVQHAVNEWIHVVYAVRKH
>CP034437.1|AZN42084.1|4846746_4849542_-|calcium-translocating-P-type-ATPase,-SERCA-type
MEHGKWHQMETGELAHSLGAKLDTGLTASAAAERLVQTGRNELTEGKKASPIKLFLGQFKDFMVLVLMGATLISGLLGEYLDAITIIAIIIINAVLGFIQEFRAEKSLRALKALSAPLAKAIRGGETVILPANELVPGDIVELESGDRIPADIRFIEANSCYAEESALTGESVPVGKHCNPIKEDELPLGDMRNIGFMGTMITRGTAKGIVIRTGMSTEMGKIANLIQQTESMETPLQHRLEQLGKILIIVALALTVMVVLAGILHGQPPYEMFLAGVSLAVAAIPEGLPAIVTIALALGVQRMIKRRAIVRKLPSVETLGCASVICSDKTGTLTQNKMTVTKLWIGGHSMDVTGEGYEPAGGCFENGKVVDVKHDQSLRRLLQIAALCNNAVVSKVDDESEAAKRKKGKGTFIQDEWLLKGDPTEGALTVLASKLGVSAKSMEGIYQRVKEYPFDSERKRMSVLVTHQGGRLICTKGAPDMLMEQCSYVLWDGKVVPFTGSLKQKVTDSAETMAQNALRVLGFAYRELRSHDATEAESDVENQLIFVGLSGMIDPPRREVRESIANCRRAGIKTIMITGDHQLTAEAIAGQLGIMPRGGLSISGQQLSGMSEEQLDRLIDNIYVYARVSPEHKLRIVKALQRKGHVVAMTGDGVNDAPAIKAADIGISMGITGTDVSKEASSLVLSDDNFSSIVAAIEEGRGIYENIRKFIRYLLASNVGEILTMFLAMMAGLPLPLVPIQILWVNLVTDGLPAMALGVDQSEKDLMQQKPRSAKENIFARRLGWKIISRGILIGVCTLGAFWITLQIAPKDPGNLVHAQTVAFATLVMAQLIHVFDCRSSRSIFHRNMLQNKYLLFAVLSSVLLMLGVLYIDALQPIFKTVPLGFRDWCLVIVAAGIPTFLMGIGSVLGTTEKKKKSKWPIQGPKSITR
>CP034437.1|AZN42085.1|4849697_4851551_+|fibronectin/fibrinogen-binding-protein
MALDGIVTRAITHELKACIGARIYKIHQPGPHDLVLQIRGGGVQGKLLISANPTYPRIHFTEQSFINPLEAPMFCMLLRKHCEGAVIEAVRQVGNERIIHLDVRQRDELGDMSFKRIIIELMGKHSNIILVDAATEMIHDGIHHVTPMISSYRVIMPGTTYIAPPEQGKDDPLAITDETTFTAALKQTADALINPPIPDEDSIHFGSVPKGADPAAITTNQLLVGAFSGLSPLLAKEIMHRTTAAGESGPLLNGVDHIDANAAQLWPAFRDMMEQFRSNRYEPQTVAASSNAKPSFSVTALTHLGGEVTAFETVSQCLEAFYGDKAERDTVKQRANDLIKFLQNERNKNAKKQGKLEETLEEAKEADKFRSLGELLTMNLHTIQRGDDFVETIDYYDEEQPIIKIALDPLLTPSQNAQRYFKKYTKFRNSLTVVAEQMQRTSEETAYLESLLQQLESASISDIDEIREELVEQGYLRSREKRGVKKRKPKQPALLCYTSSEGVPIFVGKNNTQNDFLTNKSSAPNDTWLHTKDIPGSHVVIRGTTFGDETLEEAAMLAAHFSQAKSSSLVPVDYTLIRYVKKPSGAKPGYVIYDNQKTLFITPDEPRIKQLPSVIKQ
>CP034437.1|AZN42086.1|4851613_4852462_-|PHP-domain-containing-protein
MAVTGNGQADLHSHTTASDGTMRPAEVVALAKERGLSAVAITDHDTVDGIKEALEAGERLAITVVPGVEISTIAEGRDIHMLGYYIDWENEDWRAKLGTLVSVRDRRNDMIVEKLCELGCVITMEEVIAEARAKGKDSGSIGRPHIAAVLVNKGYVSSMQEAFDRYLGSDGAAYRNPPRLHPFEAIAWIKEAGGTCIIAHPGLYGNDVLVEQIIEAGADGIEVYHSDHSEADEARYLALAQRYGLIVTGGSDYHGERNGHVFHGELGSKSVGLEVLEQLNHR
>CP034437.1|AZN42087.1|4852452_4853364_-|LysR-family-transcriptional-regulator
MALNFHQLHIFYTVAERGSFSAAAQALHMTQPAVTMQIQSLEDYFGTKLLQRSTKRIELTEAGRALMPYAKQSIELIRDTDMQMSKFTKQLKGRLQLGASLTIGEYILPRLLGPFGAEYPHIAISMKVMNTAQIMDEILNHQLNFGLVEAPVNHPDMQMEAVMSDELKLIVGKSHPLAGSKEVELEDVMTYPFVLREQGSGTRLVMEDVLRAKHIDLSAMKIVMELGSTGAVKSAVEAGLGISFVSSSSVKHEIALGLIQTIPIRDVQFKRQFYSIFLKSALLPISAVTFLTFLRERDLHQWL
>CP034437.1|AZN42088.1|4853493_4853931_-|hypothetical-protein
MKDKMTERWSTYETFHIALGDKKVADIVITNHARSRWVDRVESEKTGFEDIADFMWQSLKQGRVEPYYRNEQDVYLIDDDLVYVAEFTVIENETDLAGGPLHKMIVVTFLGRMSETIELRDLKSYYSWLRHSRRMTLIKNSRKRK
>CP034437.1|AZN42089.1|4854113_4854377_-|DUF2129-domain-containing-protein
MFSERVGYIVWVSDLKAARTLEKYGTVHYMSRKMHYVVMYMNADRAEEVIRNMSRLPFVKRIERSFRNEIKTEYTQGVPDKTRFYSL
>CP034437.1|AZN43846.1|4854406_4854895_-|YlbF-family-regulator
MNLPTYEAFDAYGGSQDQGLDMGQLLLNAYEIGDMINQSAEVAEFAYWKQVVDQNDQVHELVKQFNKAKELFVECERFGRFHPDYNAAKDKVVAIEQQLGEIECVSKFKAAEQAVDDMLHDIAKEIAFSVSETIKVPSNDPLPKGGGCGSGGSCSCGSGGCG
>CP034437.1|AZN42090.1|4855036_4856851_-|hypothetical-protein
MKLEEIAGQLTEEQKLQFGAQPLWSEIDGFNWPMSLTVSTCAREAWRKLDEPARYVLEVILLGFGRMLFSEEQLLQAAKPRLAGSELRIGLIHLQESGIVFAVRRGWGEKLYSVPNELYSVWYDAMQTEKRLPPMPEVDSYDIVPLEDSDGYVPPLSVQLLHAMAELQHTGMKRTTRGVLTKRAMESAAAQLHFDNERIHAVAELMRSDIAQSYPLPLAIMLQLALQEGWLIERKSAYEINQGKWENWLQQRASERELKLLEQTIELLSSQSAAVGIGAAQLCTQSQAYTWYRVANVEERLTRASSAVLAKQPQSTILKWCQLLCSLGWMEAAEDESGAPVFRWLIQPFEPRVTDAVNDQDETKHDEAAAIQFTPDGDIYIQEDCPYSVRWQLEMIAERRRTDRVTVYRMTERSCRRAAVQRFGAGEVIHILEAAADELLPETMRAAISIGMSAHAVMPVSVPAPEPAPVPQALSVTLHGSNQGELAPSLLVLGSLSYELIMEQKEVRSLFAGIESVPAMWMKQFRSYHLSTRRELMEQALSWRTAVKLSCEGQIKPFIPERIVDEEGKWAVVGHLQEGESCLPVKLQPDMWQEMMLVLPEGTR

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Crispr_ID: CP034437_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_12

4941527-4941712

Orphan

Consensus_repeat	Method
GAGAGAGGCTTTTCCCTCTCTCA	CRISPRCasFinder

3 spacers

The CRISPR arrays of CP034437_12

>merge|CP034437|12|4941527-4941712|CRISPRCasFinder
GAGAGAGGATTTTCCCGCTCTCAGCGCAGGATTATCGTGTTTCCACCTACCGAGAGAGGCTTTTCCCTCTCTCAATACCAGCCAAACGTTCAAAACAACCGATTTCCCACCTGAGAGAGGCTTTTCCCTCTCTCAGTATACGATTGCTGCGTCTCCGGCTATCGAGAGAGGCTTTACCCTCTCTCG

>CP034437|12|7|4941527-4941712|CRISPRCasFinder
GAGAGAGGATTTTCCCGCTCTCA	GCGCAGGATTATCGTGTTTCCACCTACC
GAGAGAGGCTTTTCCCTCTCTCA	ATACCAGCCAAACGTTCAAAACAACCGATTTCCCACCT
GAGAGAGGCTTTTCCCTCTCTCA	GTATACGATTGCTGCGTCTCCGGCTATC
GAGAGAGGCTTTACCCTCTCTCG

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN42158.1\|4939545_4940310_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP034437.1\|AZN42160.1\|4941950_4943744_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350769
CP034437.1\|AZN43855.1\|4946899_4947682_-\|divergent-polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|377404
CP034437.1\|AZN42167.1\|4950422_4950776_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
CP034437.1\|AZN42165.1\|4947874_4948288_-\|exosporium-protein-C	unknown	unknown	unknown
CP034437.1\|AZN42154.1\|4935789_4936641_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368580
CP034437.1\|AZN42166.1\|4949630_4950398_-\|dioxygenase	unknown	unknown	gnl\|CDD\|153375
CP034437.1\|AZN42161.1\|4943740_4944715_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371367
CP034437.1\|AZN43856.1\|4948368_4949289_-\|arabinan-endo-1,5-alpha-L-arabinosidase	unknown	unknown	gnl\|CDD\|350148
CP034437.1\|AZN42156.1\|4938165_4939098_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP034437.1\|AZN42164.1\|4946170_4946932_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
CP034437.1\|AZN42153.1\|4933436_4934579_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42159.1\|4940443_4941238_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766
CP034437.1\|AZN42157.1\|4939100_4939517_-\|DUF1284-domain-containing-protein	unknown	unknown	gnl\|CDD\|377735
CP034437.1\|AZN42152.1\|4931584_4933273_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226666
CP034437.1\|AZN42151.1\|4930672_4931503_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN43854.1\|4934736_4935612_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
CP034437.1\|AZN42162.1\|4944903_4945821_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42155.1\|4936760_4938041_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|376374
CP034437.1\|AZN42163.1\|4945800_4946037_-\|YqzE-family-protein	unknown	unknown	gnl\|CDD\|372887

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN42158.1\|4939545_4940310_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.28635e-11
CP034437.1\|AZN42160.1\|4941950_4943744_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.30965e-56
CP034437.1\|AZN43855.1\|4946899_4947682_-\|divergent-polysaccharide-deacetylase-family-protein	gnl\|CDD\|377404	pfam04748, Polysacc_deac_2, Divergent polysaccharide deacetylase. This family is divergently related to pfam01522 (personal obs:Yeats C).	2.90938e-88
CP034437.1\|AZN42154.1\|4935789_4936641_-\|hypothetical-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	4.78615e-18
CP034437.1\|AZN42166.1\|4949630_4950398_-\|dioxygenase	gnl\|CDD\|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	7.28238e-108
CP034437.1\|AZN42161.1\|4943740_4944715_+\|hypothetical-protein	gnl\|CDD\|371367	pfam11079, YqhG, Bacterial protein YqhG of unknown function. This family of putative proteins is conserved in the Bacillaceae family of the Firmicutes. The function is not known.	8.99852e-69
CP034437.1\|AZN42167.1\|4950422_4950776_-\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	1.55448e-14
CP034437.1\|AZN42156.1\|4938165_4939098_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.82496e-50
CP034437.1\|AZN42164.1\|4946170_4946932_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	1.41394e-43
CP034437.1\|AZN42159.1\|4940443_4941238_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	1.2897e-05
CP034437.1\|AZN42157.1\|4939100_4939517_-\|DUF1284-domain-containing-protein	gnl\|CDD\|377735	pfam06935, DUF1284, Protein of unknown function (DUF1284). This family consists of several hypothetical bacterial and archaeal proteins of around 130 residues in length. The function of this family is unknown, although it is thought that they may be iron-sulphur binding proteins.	2.39396e-26
CP034437.1\|AZN42152.1\|4931584_4933273_-\|hypothetical-protein	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	5.99345e-27
CP034437.1\|AZN42151.1\|4930672_4931503_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	5.75653e-27
CP034437.1\|AZN43854.1\|4934736_4935612_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	5.73633e-85
CP034437.1\|AZN43856.1\|4948368_4949289_-\|arabinan-endo-1,5-alpha-L-arabinosidase	gnl\|CDD\|350148	cd18827, GH43_XlnD-like, Glycosyl hydrolase family 43 protein such as Aspergillus niger DMS1957 xylanase D (XlnD); includes mostly xylanases. This glycosyl hydrolase family 43 (GH43) subgroup includes enzymes that have mostly been annotated as xylanases (endo-alpha-L-arabinanase, EC 3.2.1.8). It belongs to the GH43_bXyl-like subgroup of the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. The GH43_bXyl-like subgroup includes enzymes that have been annotated as xylan-digesting beta-xylosidases (EC 3.2.1.37) and xylanases, as well the Bacteroides thetaiotaomicron VPI-5482 alpha-L-arabinofuranosidases (EC 3.2.1.55) (BT3675;BT_3675) and (BT3662;BT_3662). GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	0
CP034437.1\|AZN42155.1\|4936760_4938041_-\|adenylosuccinate-synthase	gnl\|CDD\|376374	pfam00709, Adenylsucc_synt, Adenylosuccinate synthetase.	0
CP034437.1\|AZN42163.1\|4945800_4946037_-\|YqzE-family-protein	gnl\|CDD\|372887	pfam14038, YqzE, YqzE-like protein. The YqzE-like protein family includes the B. subtilis YqzE protein, which is functionally uncharacterized. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK. This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.	2.43346e-13

>CP034437.1|AZN42159.1|4940443_4941238_+|hypothetical-protein
MVHTFLIAPITYTPFASEDEQIQQCKEWGLLSEKATKTKLFAYKGGGLNTTCSIVGYADKMTAVLEFDNMQQHCIHPSYLKEMQTASFGVKQTFATDENSGEQEALSSDTAPATAEAVVESAETAAVHAAVAAAEADVVEAEASVEAEAPAVVEPKKKAAKKEKAPKLQLPVEKVRMTATIKEFTTVPNNFTEEEDEVIIYEAASIADPAIEIGDAWSSYSATLKKLELEIGHTLTFECKIVEKKLTKHPVRYKINNPSKLQKL
>CP034437.1|AZN42158.1|4939545_4940310_-|GNAT-family-N-acetyltransferase
MMMSLVETIEELTMNAWPSLQTVAYEGWQLRFGNGYTKRSNSVHAMYGSDGDEAVLAARIKACEAFYKKEGLPAIFKMTPLCPSTLDAELQKRNYAIADPSRVMLLESLEQLQVPHLSRIAVESTLSDEWLDHLCAFNEMTEADKVNCAKIIKQSKVKQAFFTLYDGDNPVACGLGALERGFLGLYDIVTNRSDRNRGYGEQLILHMLAWARDNGAMRSYLLVVGSNAPANRLYEKLNYKEIYRYGYRVQQTQA
>CP034437.1|AZN42157.1|4939100_4939517_-|DUF1284-domain-containing-protein
MEIRLRGHHLLCLLGFRGMGYSAKFSANMRLVYNELREQPQTLITIIGGPDDLCACFPKDAEQHCENRSVYEHDKRILDKLDFSAGMTLPWQDVIHRVRVNMQPEDINTLCYTCEWRTYGVCEAGVRTIKQGGWMPSL
>CP034437.1|AZN42156.1|4938165_4939098_+|LysR-family-transcriptional-regulator
MSEINMEWYRSFYWTARMGSLSRAAEQLHITQPAISHTLKQLEHALGGPLFFRSAKGVSLTAEGEVMLQYVEQAFNLFESGEKRIADMRNLDEGEIRIGAGDTLSKHYLLPFLEKFHKEYPNIRIHVTNQTTPETLNLLKEGKMDIGIVNLPAEDRKVKFLRSLAQQDCLVGGKAYAKLSLRLHQEPLALAQLHEYPLIMLEPGGSTRHFLDRYAASAGVELKPELELGSLDLLVQFAISGFGLAFVTRNYVEQELARGELVEIPLTPAIPERHIGVAMLRGVPLSSASKRFISLLPFAEVDVDDVDVDE
>CP034437.1|AZN42155.1|4936760_4938041_-|adenylosuccinate-synthase
MTVTAIVGANWGDEGKGKMTDVLAASSSFVVRYQGGSNAGHTIINEYGKFALHMLPSGVFYPHVTNVIGPGTALDADVLLQELQALEDRGVPKPKLYISERAQLVMPYHRLFDQLEEERLGSLSYGSTRRGIAPFYTDKYAKLGIQAADLMDSGRLRNRLSQSLAAKNVLLEHLYGTPPIDIEALLAELNDYAVKLQPYLVNTTEMLQRAIQNGDSILVEGQLGALRDPDHGIYPYSTSSSTLAGFAPVGAGIPASSIERVLAVVKAYSSCVGAGPFISEIEGEEAHALRLRGGDAGEFGATTGRPRRMGWFDAVATKYGCMIQGATEVALTNLDVLGYLESIPVCSAYRLADGTMTREFPVSAKLEGAEPILEELPGWNSDISGIRELEQLPPKAKAYVEWIEQQIGVRIATISVGPHREQLITR
>CP034437.1|AZN42154.1|4935789_4936641_-|hypothetical-protein
MSTFKVTEQQQAFFDTFGYLVFRGLMQDRIMEITEEFDQVFHKHGGNFNGKPHNFKKTSTIVAFLGHSEKLASLLDDPRVHNICSTLLGEDYNYLTSAGNKYVGDTGWHSDTTMDKKWPGNLKSINLSFYLDPVTRETGALRIIPGSQFIGDQFTERLKAQIHTADMQGQWGVDRTELPAIPIDIRPGDLLVFNNYVKHAAFGGGNNRRVLLINFSRHYTDEHMDELQEYVSTFAPYWVEELHGEAVLTGASEERMRHLRQIQDNQAHLPALARAARIASSQS
>CP034437.1|AZN43854.1|4934736_4935612_-|cation-transporter
MIAMWISLLSNVLLTGLKLIVGITFNSQVLIADGIHSAGDIIATATAYSSMRVSGKPPDEDHPYGHGKAEVLGAGVVAFILIAASLYMGYHAVLAFFGPPSEAHLIALGAAIISLIAKQILYVYTLRLSKQTNSKAMLATAYDHLADVYASLAATVGIGLGWLGERNDIDWLSYGDPAAGVVVSLLVLKLGVDMAREAVDVLMDKSLSPDKIEDITEHLHEVSEVKRIDRLRAREHGHYVLVDARVSVLGTLTIQEGHDIIRKIKQKLMDAHPEVDEVLVHLNPWYEDDQQ
>CP034437.1|AZN42153.1|4933436_4934579_-|hypothetical-protein
MKLNKKKVIIVATLAGLMATTAAVEASGFLQKVQGFLRSDITVSVDGSKTSMKPVFINGQAYLPAKSEAAALGYDVTYNAREKRLELTNKEEQGPGEQDLIRMQGIIESVETGTDGSTRITVLGRGGSNWMVLSVDKDTVLTDSQGKKLDPKSLKPGQDIQEAQYGPIVAMSYPGQSHAAKVIVGSDHLVKDAVIQSVKKTDDGWQVTINNSVNGESATAVVLNSGKETQVVDQERQPLEFSKLKAGQKVRAYYGPIMTKSLPPISPVFYLVADTSTAAGTLSPAAVAEFQTLSWNTLTGDQKSHLKSKKEEAEVTLVNAADSGILASTDEQKKALADLKAKGGSIVVVSYKTDQDELIGPLSLGFDSDSKALLGYGIRK
>CP034437.1|AZN42152.1|4931584_4933273_-|hypothetical-protein
MTPLIQRIWKYRLHYLIVLPALMLLLIFKGIPLVEMTYSAFVDYKVIDSIWGSKWVGLANFRVLFDNPAFETVVRNTLIMKLGYTLACGIAAFVAALALSCIRSHRYRSGLAALFLAPYFLPSLLFAYMVMVILSPAQSPFGGIHTLVLARPDLFRSLFISLEVIKTSGITIMLALATIGATQSAMVKGLVPNRTSFFSRHVLPALQAIGAFMLMQLSSVLTQDTELLRMLVNPLVFESGDALGSYSYRLVFENFELNLAGPLGLFELLIQLAGTLLAYAVIRRTFAKTLFAAGSGSDSAPSNVIQPKPRYNAAGIVIGTMLALVAAFVLYMFFVYPFTAKHAEGPGLESLLSMRNYMRYMAIDLAAVIPFMLITVTLAFPLTVKDLPGRGLYKFVLLILLVMGSGTFYEFLFYKDLHMLNTVFPLFISGIFSILPVFILKSIASSRMTLQEDVEGKGELHKFFYVYLPSCWQPLLALGALQFVMQWNSVTLPTIIMSNPSKFPPLQQFMIAMHSGAGTKAAYSPAVLLQFGAIILLPSLIVLLVFRKWLTAAVLTSQIRNL
>CP034437.1|AZN42151.1|4930672_4931503_+|AraC-family-transcriptional-regulator
MKNKREASALMELLQALQVDVSHAQKTQVTTDWRDMDYVPEYNKLYYIVDGEGYLKVDGNEMYPVPGELCLMPAFSQQSYSYLEGKKPYLKYWCHFTASIGPFDLFQWIGVPLRITTADQEEMTALFKLLVSLHANPSLISRLREKSIMLEIIARYLEHVPITILQHRSEDMKRIQFIQEYIDSHLESTLKIEDMAKAAHLHPNYFIAYFKKHFGVPPLKYVSRKRADKARILLTTTTLSIKEIADQIGFKETNHFAKFFRKEAGQSPTEYRANNS
>CP034437.1|AZN42160.1|4941950_4943744_+|DEAD/DEAH-box-helicase
MQPTNDPIKEAPAVKRKLHPSVDLQFDRTWLHNLQDRVDRNGPWDDWTMYQLAIEAEQSRLIGSFDDLQCLRSLPSFEPMTHQISTARKVLHEMSGRAILADEVGLGKTIEAGLVLKEYIVRGLVKKALILVPASLVLQWVRELNSKFGISAVAQKKEHSWANDIVVASMDTAKRDPHRERLLAQDFDILIIDEAHKLKNKKTTNYQFVNQLRKKYCLLLTATPVQNDLDELYNLITLLKPGQLGGQNEFAANFVLDKRLPKNEEQLHEALSTVMIRNRRGDGDIHFTKRIVKNIPLDLSNEEQALYDGVTKFVRERAGESDGDWSSLLSLVTLQREVCSSRDAVFVTLVNMFKKTPEDSPHRAKIWELVEVIRAITSNTKAEKAMELVREMNDKVIIFTEYRATQEYLLQYFRANNMVAVPYRGGMNRGKKDWMMDLFRGRAQVLIATEAGGEGINLQFCHHMINFDLPWNPMRVEQRIGRVHRLGQTSDVRIYNLCTKGTIEEHIVNLLHEKINLFELVIGELDHILERFEKNESLEQRLARLMLETGGNGDLLRKQIDDLGNSLSRIRDEVELEEDEMSAINSIMNAVGQEVRP
>CP034437.1|AZN42161.1|4943740_4944715_+|hypothetical-protein
MNERQIQKFVQRYLDATGCHIVEKSPAHFHVKLSPKADRDLTNRPYYWSFVDRTGADPETMSLLLVTDKQKYDNQAAAQAEAAQKQQSSPSNAEANSAQTPNSAEAALNRSFGYIHGTLNTNIRVPREDLYFGSRRLNQLFESSRQGGSYLCLFQEPDKRSNSPLDSTAYSAWLGVNMKVEFACDMKREEFHSFGISLATGQCIEQFHDRLLQYRMTPKLPPNVHTAKNALTLVKAAAIAEQTLERKLRNYDYSWAVAAAKRLNEELDTINHYYEPLLESAEEENKPQITEQFERRQDEIRWQYEPRVTASAINCGIFYLQGIG
>CP034437.1|AZN42162.1|4944903_4945821_+|hypothetical-protein
MMQSFRRLILILALLVSAFFLMNNEVSAAAAAASSSAIHAPAVVKSKLEQQVSAWSDTLSKQKGFEAWKYATPVIVPIGPGTHGWLVTFQLNHEPVGYMIVNATANGGFALGEYGAGNHPAFDPNTLYRSLIRQGLITSFAEAIKKPLHLERLYLSPVLAVWKWTTAAGETYYLDAWTAEALPITNKMWDEQSAAVSAKLNQQAPTLTTVSEVRTNDCFDPYERMPWLTKAPLSYDQVRLHLPEYLDQLSQIRYTAELYRQTVLFVFPAIGYHKWNSSSIFIEVDYEGSRYIPMATMNTLGHFYR
>CP034437.1|AZN42163.1|4945800_4946037_-|YqzE-family-protein
MAVEKPEEYIKFITGKAINFIDMPMDTRRENRQKAKATREPWLTRWFGIGGFGVMQWIKSTAREESNEEQSDLPVKMT
>CP034437.1|AZN42164.1|4946170_4946932_+|N-acetylmuramoyl-L-alanine-amidase
MSKSVDLIQKTLTRLILPLCTVLAITASQPAPCTAAAYPLDAPAKYTNTRVLPPDYRRALPSAEVLIDVGHGGIDGGAHHEHVLEKDINLAIAKKLYLLLSASGINAVLNRDADYALSDDNRWNPARSRHRRDLSQRSQLTKEIQTRILVSIHVNWAPDKTEYGPLVLHQNEGESALLAFCIQDALNRKQNTRALPRVGKPFYLLNVVKQPAVIVELGFLSHEGDREMLTNPRKQVQLAEAINSGVRNYLLLR
>CP034437.1|AZN43855.1|4946899_4947682_-|divergent-polysaccharide-deacetylase-family-protein
MITAALMLLMPLSGGIAKASEQSEVKGNRQVAIVIDDFGNNMTGTREMMELPVHFTVAVMPFLPTTKQDAELAHKLGHDVIVHMPMEPVKGKPEWLGPGAITTAMSDEEIRKRVEEAINEVPHAVGMNNHMGSKVTADERVMRVVLSVVKTHGMFFLDSRTTFKTVLPKLTAELGVPLLSNQVFLDDVYTASHISKQVGILRKYLESHDSCVTIGHVGPPGKMTASVLKASIPSMQSNTTFVTLSQMIIPSAEKEIVPHP
>CP034437.1|AZN42165.1|4947874_4948288_-|exosporium-protein-C
MTHVIWFNASVPAVVTDQVHIEIPLTPEKVILAELGVFIAPHYANNRVQLIATVGVGGEEASISQLLFRLFRGTQEIYYALQGVEPGYERNMIVSFQAIDTNVSEGSHGYSLYVERMTESGAAVIGPINLSATVYAW
>CP034437.1|AZN43856.1|4948368_4949289_-|arabinan-endo-1,5-alpha-L-arabinosidase
MLKRTSGNPIFEGWYADPEARIFENKYWIYPTYSAPYEEQRHFDAFYSTDLIEWTKVDRILEMSSISWAWRAMWAPSPIERGGKYYYYFAANDIQSDDEIGGIGVAVADRPEGPYRDAIGKPLVDKFHHGAQPIDPHVFIDDDGSAYLYYGGWGHCNVVKLNDDMISIGTFEDGETFKSVTPEHFVEGPCMIKRDGFYYFMWAEGGWGVPDYSVAYAKATSPLGPFERVGKILQQNPEVATSAGHHGMIQVPGTDEWIIVYHRRPLTETDRNHRVVCLDRMEFEEDGSIRPVQLTFEGVSARPIGE
>CP034437.1|AZN42166.1|4949630_4950398_-|dioxygenase
MISPVFLAHGSPMTIFEQSEFTAFLNRYGKENRPKAIVIFSAHFESEITTIAATDDVHEMVYDYYGFPPSYYQVQYPARGSSIVANMVEERLRLHNIPVQQKYRGLDHGVFPIMMHAYPDADIPIVPVSVNPFLSPREHIAIGEALQGLEKDGVLVIGSGFLTHNFGEIDRAGDAPPRQWAVEFRDWIREKVLARDIESLSQYETLAPHARRGVPRAEHFVPLLIALGANTPGKDIRVLYDTIEHGSLSTLSVQF
>CP034437.1|AZN42167.1|4950422_4950776_-|DoxX-family-protein
MNIALWIIQGVLALMFVMAGMMKAFNYEKVKASMPWSSDYSKGTVNFIGWSELLGGIGLILPFAIGVAPVLTAIAAIALAFVMVLAVGVHAKRKENQAIGMNIILVVLLVFVAIGRM

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Crispr_ID: CP034437_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_13

5267995-5268068

Orphan

Consensus_repeat	Method
TCTAACGAACTCAGGAAGCGTTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP034437_13

>merge|CP034437|13|5267995-5268068|CRISPRCasFinder
TCTAACGAACTCAGGAAGCGTTATACGACCATATTTGCCGTGTAGGATTTTCTAACGAATTCAGGAAGCGTTAT

>CP034437|13|8|5267995-5268068|CRISPRCasFinder
TCTAACGAACTCAGGAAGCGTTAT	ACGACCATATTTGCCGTGTAGGATTT
TCTAACGAATTCAGGAAGCGTTAT

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN42428.1\|5278731_5279952_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
CP034437.1\|AZN42422.1\|5270211_5270421_+\|alpha/beta-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|365990
CP034437.1\|AZN42416.1\|5263252_5264398_-\|WG-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379719
CP034437.1\|AZN42418.1\|5266580_5267129_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|225998
CP034437.1\|AZN42419.1\|5267299_5267956_+\|transcriptional-regulator	unknown	unknown	unknown
CP034437.1\|AZN42424.1\|5271105_5271702_-\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|234620
CP034437.1\|AZN42413.1\|5255844_5261925_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379104
CP034437.1\|AZN42415.1\|5262572_5263166_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN43884.1\|5253295_5253640_-\|DUF1806-family-protein	unknown	unknown	gnl\|CDD\|378061
CP034437.1\|AZN42427.1\|5275952_5278607_-\|DNA-polymerase-I	unknown	unknown	gnl\|CDD\|235591
CP034437.1\|AZN42414.1\|5262057_5262576_-\|HupE/UreJ-family-protein	unknown	unknown	gnl\|CDD\|379373
CP034437.1\|AZN42420.1\|5268387_5269407_-\|glycosidase	unknown	unknown	gnl\|CDD\|350126
CP034437.1\|AZN42426.1\|5272587_5273460_-\|DNA-formamidopyrimidine-glycosylase	unknown	unknown	gnl\|CDD\|234899
CP034437.1\|AZN42411.1\|5253930_5255217_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133058
CP034437.1\|AZN42429.1\|5279914_5281465_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|341373
CP034437.1\|AZN42421.1\|5269614_5270079_-\|transcriptional-regulator-NrdR	unknown	unknown	gnl\|CDD\|234774
CP034437.1\|AZN42412.1\|5255234_5255735_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42423.1\|5270521_5271109_-\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381617
CP034437.1\|AZN42417.1\|5265038_5266460_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
CP034437.1\|AZN42425.1\|5271767_5272490_-\|sporulation-membrane-protein-YtaF	unknown	unknown	gnl\|CDD\|274321

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN42428.1\|5278731_5279952_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.20026e-64
CP034437.1\|AZN42422.1\|5270211_5270421_+\|alpha/beta-type-small-acid-soluble-spore-protein	gnl\|CDD\|365990	pfam00269, SASP, Small, acid-soluble spore proteins, alpha/beta type.	5.47982e-27
CP034437.1\|AZN42416.1\|5263252_5264398_-\|WG-repeat-containing-protein	gnl\|CDD\|379719	pfam14903, WG_beta_rep, WG containing repeat. This repeat contains an N-terminal WG repeat motif. The extent of the repeat is poorly defined. This repeat may form a beta solenoid structure (Bateman A pers. obs.).	2.33021e-07
CP034437.1\|AZN42418.1\|5266580_5267129_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|225998	COG3467, COG3467, Predicted flavin-nucleotide-binding protein [General function prediction only].	3.31402e-42
CP034437.1\|AZN42425.1\|5271767_5272490_-\|sporulation-membrane-protein-YtaF	gnl\|CDD\|274321	TIGR02840, conserved_hypothetical_protein, putative sporulation protein YtaF. This protein family was identified, at the time of the publication of the Carboxydothermus hydrogenoformans genome, as having a phylogenetic profile that exactly matches the subset of the Firmicutes capable of forming endospores. The species include Bacillus anthracis, Clostridium tetani, Thermoanaerobacter tengcongensis, Geobacillus kaustophilus, etc. This protein, previously named YtaF, is therefore a putative sporulation protein. [Cellular processes, Sporulation and germination].	9.45188e-62
CP034437.1\|AZN42424.1\|5271105_5271702_-\|dephospho-CoA-kinase	gnl\|CDD\|234620	PRK00081, coaE, dephospho-CoA kinase; Reviewed.	1.97294e-94
CP034437.1\|AZN42413.1\|5255844_5261925_-\|hypothetical-protein	gnl\|CDD\|379104	pfam13287, Fn3_assoc, Fn3 associated.	4.52828e-07
CP034437.1\|AZN43884.1\|5253295_5253640_-\|DUF1806-family-protein	gnl\|CDD\|378061	pfam08830, DUF1806, Protein of unknown function (DUF1806). This is a bacterial family of uncharacterized proteins. The structure of one of the proteins in this family has been solved and it adopts a beta barrel-like structure.	2.17953e-63
CP034437.1\|AZN42427.1\|5275952_5278607_-\|DNA-polymerase-I	gnl\|CDD\|235591	PRK05755, PRK05755, DNA polymerase I; Provisional.	0
CP034437.1\|AZN42414.1\|5262057_5262576_-\|HupE/UreJ-family-protein	gnl\|CDD\|379373	pfam13795, HupE_UreJ_2, HupE / UreJ protein. These proteins contain many conserved histidines that may be involved in nickel binding.	3.39721e-48
CP034437.1\|AZN42420.1\|5268387_5269407_-\|glycosidase	gnl\|CDD\|350126	cd18614, GH130, Glycosyl hydrolase family 130; uncharacterized. This subfamily contains glycosyl hydrolase family 130 (GH130) proteins, as classified by the carbohydrate-active enzymes database (CAZY), most of which are as yet uncharacterized. GH130 enzymes are phosphorylases and hydrolases for beta-mannosides, and include beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281), beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319), beta-1,4-mannosyl-N-acetyl-glucosamine phosphorylase (EC 2.4.1.320), beta-1,2-mannobiose phosphorylase (EC 2.4.1.-), beta-1,2-oligomannan phosphorylase (EC 2.4.1.-) and beta-1,2-mannosidase (EC 3.2.1.-). They possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Beta-1,4-mannosylglucose phosphorylase is involved in degradation of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine linkages in the core of N-glycans; it produces alpha-mannose 1-phosphate and glucose from 4-O-beta-D-mannosyl-D-glucose and inorganic phosphate, using a critical catalytic Asp as a proton donor.	1.74183e-116
CP034437.1\|AZN42426.1\|5272587_5273460_-\|DNA-formamidopyrimidine-glycosylase	gnl\|CDD\|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	1.74533e-145
CP034437.1\|AZN42411.1\|5253930_5255217_-\|glycosyltransferase	gnl\|CDD\|133058	cd06436, GlcNAc-1-P_transferase, N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine. N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.	2.73001e-49
CP034437.1\|AZN42421.1\|5269614_5270079_-\|transcriptional-regulator-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	2.67441e-84
CP034437.1\|AZN42429.1\|5279914_5281465_-\|GGDEF-domain-containing-protein	gnl\|CDD\|341373	cd04598, CBS_pair_GGDEF_EAL, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and is thought to be involved in regulating cell surface adhesiveness in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.95397e-34
CP034437.1\|AZN42423.1\|5270521_5271109_-\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381617	cd16896, LT_Slt70-like, uncharacterized lytic transglycosylase subfamily with similarity to Slt70. Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.2481e-69
CP034437.1\|AZN42417.1\|5265038_5266460_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	4.48256e-142

>CP034437.1|AZN42419.1|5267299_5267956_+|transcriptional-regulator
MILFVDAYEQWLRTHILEESNSRRRELLEKGLGHGTREFLRIIWYPAVRNFNQLYPEWEVRDFNNGYRYVDLAYLPVGGMKGAIEIQGYGPHAWDLDVRRFKDLCWRHSLLALDDWILLPIAYLSISEETQRCQQLVLSFIGKFVTTTELPEHLGWLETESVRFARRLLRPFTPTELAAHLRVSDQHARRLLHKLVDHQLIVIAGGAQRYRTYAIRTT
>CP034437.1|AZN42418.1|5266580_5267129_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MFPIRLAKRACTDSARIQQFLEQAQIGYLGLTTDDIPYVVPLNYYWREGAVYFHGAAEGRKITMIDRNPRACFTVSEEYGTIASPIPAHTDTAYMSAIVDGTIVKVTDIAEATEAMQGMLNKYVPGYYDKPMPQSHLERYVSSMGSKTAVYKLISTSITAKENEAQPDHMFYPGRTIGSDRQ
>CP034437.1|AZN42417.1|5265038_5266460_-|PLP-dependent-aminotransferase-family-protein
MISLTPKLEKESESPLYDQLYRYIRKQIEDGSLAVNDRLPSIRQLSAHLVVSKNTVEAAYQQLLSEGYLQSRPRSGIFVLPLEQVPEVEGKPGASVRQQSEKPLHESSLQGRVGTIDFEYGDVELELFPVKAWKRCLAEAMDNRLHEVIAYGDRQGHLGLREEIARYLFQSRGVACSSHQIFLSAGTAHAVSLLCQLLPLTERIAMEEPGYNGVRAVFANHGKDVVQIPLEEDGLSIEALQGCGANVVYVTPSHQFPIGIVMPVQKRGKLLQWAYEQGGYILEDDYDSEFRYQGQPIPALKALDRSDRVIYLGTFSKSFLPGARLSYVVLPESLADTYRNGLQNYSQSVSTLVQTAMYLFMRGGAFERHIRKMKNLYQSRHRALLRAIHDQLGSRVGIIGQKSGMHLLLDVYGRECEELIQLAAERGVQVYSPMKHWTNPAECPRSYVMLGFAGVQEEQIREGVSLLRQAWFE
>CP034437.1|AZN42416.1|5263252_5264398_-|WG-repeat-containing-protein
MLFILSIMAVISAGILAANKKADTETILYPVQVGGKWGYINKMGKIAIKPSYAWADDFHEGVAIVETIKTSNGSKDEDMEDRVRYGAIDSSGKMVVKPVYSSITKYTEGVAGAIIADNAADLKYFILNNKGKVLYALPENMQIVSMLFNGSQLPTQSEGMILVQDDLTEKYGYINRYGKVILPYQYNEAANFSNGLALVKNDHNQNEYIDAAGKVKIDASKYITGKSFSEGLAAVAVQDKKSSAAVYGYIDTQGNMKIKPQFARAYAFSEGLAKVCVGESINSFSIGYIDPSGVYRIGPHLKDNYEETLFSEGLAPVDEGKGGYMDKDGRFSIRPIITSGNDNYLRQNKAGEFREGIAKVLLSDGRLGYIDRTGTYIWDPQ
>CP034437.1|AZN42415.1|5262572_5263166_-|hypothetical-protein
MLLSFEHRADAHAYSATYSALEFYKTKTELTYALDDKSVIELAGGDTNHDGTLDSEEFAAVDQKLLTILQTSLVVKINGESTAWLQIESLTIDRKSAILKAYFPAVAASQTIELTDNLYLNDSRSNYVNLLTIYNGAERSTAALSGGNRTWKLQMTENDYAGLQSGETISQQPQEQQPEEDASSSSTDGWLSFLNWG
>CP034437.1|AZN42414.1|5262057_5262576_-|HupE/UreJ-family-protein
MNHILSGYDHLLFLFSLLIARQTFKQYAGTITAFTIAHSITLASTVTGVIHMPSSIVEPGIALSICYVAFDNLHRKEVSHRWMLTFIFGLIHGMGFADLLTEMNIPKGELAVDLISFNVGIETIQVIIVALVLPALALIYRWKHARRVVIACSAAALMMGGLWFVERVFFYV
>CP034437.1|AZN42413.1|5255844_5261925_-|hypothetical-protein
MKTLKKVLLSVGLICLLLVNSLVPALPATTAFAAISGSSSVENPPQSLVGKADVASWNYTNATQVTNAAGNFATTSGYYSNPIFNSTLQLFKSSGQITSGLNYSSASISASAFNLQTDKAYWYITTSSAGFKDLIFNFSARSSATGPRDFNTEWSTDGNNWTLFGNAVTGTGYTVKIESTSLEQFGMALPAGAANQNKLYIRILQKSEVSEGNGTVASGGAFNVNTLQLFGTKDPAYTTTAVTATPDTAGAILDAAPITLANTDPNAQIYYTTDGSTPATTVGGSTKLYTEPFTALSAGGFVGTNPFVVKAVAKSPTLLSSDPVTLSFNQQTVTSNADAKNLASGTYAWVKGIGTYLNGNTTLYIQDGMNAGSGLTIFKTGADFSSYVGKEIYVYGKASPYNGLMEITPDAVSAATVVVRNSSPTLPTPTKIMFSQLADRTYESMLVSFDTVKLVTVGGTNTGSSFNHTVSQAGISYTLRGKGIPTAVGVNGSYVNITQAIASYFNGIQLVSANAADLVAATDPTVDFMTSSVPSGSSLPLNAKVTLSTATANATITYSLNGGAPVTSTANSVEVTVDAFQNGTATITATASDGSYTTAAQTFKFTQSKAAAVSANPGSAAITVTTPIALTSATANATILYSIYKNSYSSSDGTLVGTANQTYSAPITLDASYFPVRIVTQATLQNYLDSDPVTFKYTAKKATGGEKNYYGSLHAHTLNSDGQGTLAEAYAYARDQGKFDFFIVTDHSNSFDTAQYDVKTDHNINDYNQANTGWLAGKQAAADAATPTFVTDYGYEMTWSGGPGHMNTFNTTGFVSRNNATLNDKANDAGLQTYYQMLEGTPGSISQLNHPGATFGNFANFGYHDNAIDDKVTLVEAGNGEGAIGSGGYFRSVDQFILALDKGWHVAPTNNGDNHKKGWGTSNTAATVVYTNDFTLAGIYTALHDRSVWSTENRDLDVTYHLSDGTNTYSMGAIVDTPPATANITVTAANKNPGKETSNIASVQLISNGGKIVDQKTYPVGTSNVNYTYSMTAPAAGYYFAIITDNQGFVAVTAPIWLGSAPKIGITSVTNSSTMPVTTEALNLTTNFFNNESTPVTLKSVSYTVDGDSAANKTYNVGTTISPSGVANHVFSYTPTTTGTKTVTISAVITVNGVDDTYTATSTMKVIDINSVSYVGLDASHGNEYVSGGSYPNTMANMMTLAGANGVRVVQLNTSSELIAATSNPKYKMIILNAPSRKNVAVWPTPANYTTAEIAALKAFSESGNTLVFGNIADFGESTNADPTSPKKHMSELQNDVLAAIGSTLREGDDEVMDDDKNGGQAYRLYPTEFNMANPLLEGVVDGQTYSQYSGSTIYAVDPASGARTSTLPATVSPLVFGFPTTYSAETDNDNFGYGTTMSTFPYVTVGTNKTDKGINNSQGLYIPKYVNPTSEVATNPEEKLLAASETVTHPNGKTSLVVVAGGSFMSNFEIAITVDNAGTLPYVNYNLMENLYKTVNPVTITSVADAKNLPDGTDVVIEATTTSEVNTQSSNADTNKGFFDSIYAQDATGGINLFPVASGIQEGQKARFEGKIAHYQGEVELTVTKFTIMDPSIHKVAPTALSTAASMSSANTGLLVKTEGVVSNIDKDTDGTINQFTIDDGSGPAIVFINGYITKGTPLPFITDGARVSVSGLASIGEVVSDADMHPRIRVRDRSEIVEVGTDNTPDTPDVLDLQLAQFYSSNGNWYNAVYYYGLAISGGDTGLDSEMSTASQQLQQQAISHMEAGNYSQSYAEYELLSTSSGVPLSIKTDATQSISSSTNMGLAWYYLEQDNLYNTLYYLSEEIGSSNNSTGISALASFAASMVQQDAKNQTEQGNFGAANAEYQLLNSSQGVPASIAQDAAGSLASGSNIGDAWYYIGNSNWYNAVYYLGIEMQTNASTGVAGMMAYAAKQLQQEASNLTAAQGSFAQSYADYDLLTNTANVPASIKQDASKSIDVSDSDYGNALWYLNQSDYANAKYYLQQVAAKGNNSTGVNALLAYVNGK
>CP034437.1|AZN42412.1|5255234_5255735_-|hypothetical-protein
MRPEEMTVRRTLKSGKSFLAVMSILLSMFVFAFFGWNLNEVEASGSVQTSNNNVTVSGNVKNSKGQPIGNVLVKIMVQSYVLDKKTNKHVYVWVTAAKALTNSKGQYGAHVQKPTTGKIKVEWVRKGTTNPVLIKTFNIEKNSGQFAFDLKTTNSFNPLATIGFSY
>CP034437.1|AZN42411.1|5253930_5255217_-|glycosyltransferase
MTVNADIFLVFFGMLSLYYLIMYLLSFKKFSMPGSDHNELGFVIFVPALNEAKVIGETCSQLNTIHARLHVVVINDGSDDGTGEVVQRYEGDRIHQFRRTAPEARQGKGMALNMAYAWARTQFKEWFPDLRDDQIIIGVTDADVYLHQNVIVEVASTFQSASDVGAVQAPVSIKGANENLWLLMQDIEFQAFFLYIQKARNWISSVAMGGNGQFTRYSAMKTLGDRPWTRALTEDIDLGLALTGHGHRICFTGKTPVVQHGLTSFHRLLKQRSRWVQGHYQVWKRLGSLWRSESRLITKLDSTLYLMMIVIPLVLAADYALGFASLFGLVRVDSDLMFWLHGFGSWIPSTVQMILGFSIQLIFLPSYTRTANIKIPWYVFPGLMATFSIYTATIWILASVIAFYRMATGKWGWIKTERETISTNTSSA
>CP034437.1|AZN43884.1|5253295_5253640_-|DUF1806-family-protein
MQPINPSDIQARIDALKEQELYIHLEMTTGAYAAHFDSSKHPGSIFITNTTVKFSHGSISGSGPYRIGLKMEQGWIYAEGLTYYEEQEKERLIMAGHDSQGKLIVAFQLSKTPF
>CP034437.1|AZN42420.1|5268387_5269407_-|glycosidase
MKITRCESNPIVTPGLYDWRKATVFNPAVIIEGDKFYMIERTAGSLDPFQCFFGLLESEDGVNFKHVLDKPIIHPEQFGFPYGSIQDPRVVKLDDTFYLNYALRPCSMSYYPTGVGIPNNSKPVYPDGWGEEDVHWRTRSSIATSKDLINWEFLCDTTPLDINDRDNILFPEKIGGKYALLRRPEEFIGEAYGTEKPAMWISYSEDLITWEDPILFATVEQEWELKKIGGSTPPIKTDKGWLVLYHGVGPDHIYRVGAMLLDLEQPEKVVARAPGFIMEPETYYEKFGLFIPNVVFPTANVVKDGLLYIYYGATDTAICLATVPLDELVDYVIAESEKG
>CP034437.1|AZN42421.1|5269614_5270079_-|transcriptional-regulator-NrdR
MKCPYCDYAGTKVLDSRPANENKSIRRRRECEKCTRRFTTFEMVEETPLIVIKKDGSREEFSRDKILRGLIRACEKRPVSVDQLEIIVSEAEKELRTTALAEVESREIGELVMSQLYPVDEVAYVRFASVYRQFKDIDMFMKELSNLLSKNPLE
>CP034437.1|AZN42422.1|5270211_5270421_+|alpha/beta-type-small-acid-soluble-spore-protein
MANGNSNQLVVPQASAALDQMKYEVAQELGISLPQDGYYGNITTKDAGSIGGSITRKLVQIAEQSLAGR
>CP034437.1|AZN42423.1|5270521_5271109_-|lytic-transglycosylase-domain-containing-protein
MKKKRRNKFRRRVILILVIALLTLLFVRSEWMSHWMYPVKYRSDIVISATNYKLEPHLVAAIIRVETNYKPGVVSKKGAIGVMQLMPDTAKWIIERGGFTNVTLDAISNQPDIGIEMGSWYLNALYNQFDGNMYTVIAAYNAGPGTVNRWLKAGTWDGKLETVDQVPYGETRHYVQRVIYYYNKYKDLYPDLLAE
>CP034437.1|AZN42424.1|5271105_5271702_-|dephospho-CoA-kinase
MKLGLTGGIACGKSTVGAMLLARGAKLVDADQVAREVVLPGEPALAAIAAEFGQAVLNADGTMNRPEVGKLVFGNPERLSKLESILHPAIRSRMWDRIEAYEASDPNQLIVADIPLLFETGQDAMYDAVMVVYVPQAVQLERLMQRNQLTEEQASQRIGLQLDIEEKKRRATYVIDNSGSLAETEQQVERFWREQGLP
>CP034437.1|AZN42425.1|5271767_5272490_-|sporulation-membrane-protein-YtaF
MLVHAASLLLLAFAVSLDGFGVGVTYGLRRIRIPLFSVIIIAFCSGLVVWLSMQIGSVLTGYMSPSVAKLIGALLLMCIGVWALIQYWQRRKAGADRADEETAAETATQVSGIAITEAQPAAGELAASAIVNLELKRLGIVIQILRTPQVADVDRSGTISASEAILLGFALSLDSFGAGLGAAMVGFNPLLTAFVICTASALFLLAGMRLGFRFAGWRGMQALSILPGIMLIVMGFLRLM
>CP034437.1|AZN42426.1|5272587_5273460_-|DNA-formamidopyrimidine-glycosylase
MPELPEVETVRRTLNELIAGKQIERVTVTLPRIIQKPQEPEIFAAALAGHTIQSVERRGKFLRIILDGLVLVSHLRMEGRYGVYKQDEAVELHTHVRFHFVDGTELRYKDVRQFGTMHLFAPGEDLTLPPLNKLGIEPLDEAFTLQAFKKEVAHRTTKIKPLLLNQEYIVGLGNIYVDEALFSAGIHPERTANTLKAADWSRLYDAIRATLSRAVDAGGSSIKSYVNGQGEMGMFQHELLIYGREKELCRSCGGPITKTVVGGRGTHICLRCQPLPKLRTKAKQVRQSAK
>CP034437.1|AZN42427.1|5275952_5278607_-|DNA-polymerase-I
MAKWILIDGNSIIYRAFFALPQLTNSAGMHTNAVYGFTTMLLKLLEDEKPTHMLVAFDAGKTTFRHEGYAEYKGGRQKTPPELSEQFPVLKELLKSFGIAQYELPGYEADDIIGTLSRIADEGGIETVVVSGDKDMLQLASDNVTIALTRKGISDVERYDPAEINERYGLTPLQIIDLKGLMGDTSDNIPGIPGVGEKTALKLLHEYGSVEGVIAGVNELKGKMKEKVEEHQESAVMSKKLATIYREVPLEHQADELVYNGYDDAALGDAFRKLEFKSLIERLGLSEVGSTAVPAAEANYEILSLSGLPASEVSKLLAASESIYIEAIGDNPHQARLIGIAVASGDRILTVTYDELMGTTLSAPVRAWLEDEHAPKKGYDLHKAELTLHWMGIDLRGVELDTMLAAYLLDPTDTSLTLAALIARYKLAAIQSDEAVYGKGAKFQVPGSDVLAAHLAAKADAVRRLVPVLTEELEKGQMSKLCYELEQPLAVVLAGMEKQGIKVNPAVLEDLGAELERNIAQYMSDIYTHAGMEFNINSPKQLGEVLFEKLDLPAWKKTKTGYSTDAEVLEKLAPYHEIVGLILHYRQLAKLQSTYVEGLLKEIRRDTGKVHTYYRQTIAATGRLSSQFPNLQNIPIRLEEGRRIRKAFVPSEPGWTILAADYSQIELRVLAEISGDENMKEAFIKDIDIHTKTAMDVFGVTADQVDSNMRRQAKAVNFGIVYGISDFGLSNNLNITRDEAARFKEQYFAAFQGVRAYMDNIVVQARENSYVTTLLDRRRYLPDIHASNFNIRSFAERTAMNTPIQGTAADIIKLAMVNMDKELRARGLRSRMLLQVHDELVFEVPQEELELMKTLVPQVMAGALKISVPLRADVSYGDNWYEAK
>CP034437.1|AZN42428.1|5278731_5279952_-|EAL-domain-containing-protein
MPMLQPKYLRASERGNNVIATNNELMGIIYFAWHGKAQEQAEISGRLQAGWKPFAERLLQEQKPEELSGVSRLWLRDDLFVCIKLPYVGRELMEEQLLELGSQLRQNWEQQFVNAVFGGKVPELSLHAGVSILDSGIRSEQERMYEGIKQAIIHGQSTSATERGLKRRTLDQILHGRLIQPVYQPIISLQCGTDAAYGYEALTRVPTQRWFDGPLPLFDFAAEEGLTYSVDRLARERAIECSTGLAAGQKLFINITAQIMHDPTFTPGQTLLLLEQYGLSPHHVVFEITERSSIEDFASAKKLLEHYRSQGYQIAIDDAGAGYSSLQSIVELKPDYIKIDRSLISGIHQDDMKGHLVHTFTELAAQMNISLVAEGIEEEAELTFVKELGVQYAQGYLLGRPRPTIG
>CP034437.1|AZN42429.1|5279914_5281465_-|GGDEF-domain-containing-protein
MHVDEVGYGLLDRTMIQRLRERLFSGGIGIIIAHLSAIVPLSVQEAMSEWVVEQRGLVWRYKMENDYFFFLQRGGKSEAKLDKLLRSAVDTLQSKLLSGYEGLEERGGVKDSKVIIGFASAVPSTTGRSAEATIYKGIREAVNSMLQQQLLGQNVANEQAAAATEQDAFASGSRSMEQREWSWGSSTGSKGLHMESPAPFLIGALAKPIPTFAPSSLVSDLARMFEINTHVQGAVIASEGKPLGLVMKENMNQLLAGQFGLPLYWNRSITRMMDEEALVVDANLTVEQVAQQAMARDISRLYHVVIITRNEKLIGAASIRSILECMTQLRTEEARTANPLTGLPGNATIQREMQRRIDAGKPFSIIYGDLDYFKWYNDCYGFSQGDELIRFLASVMEDVTRLAGEQRDFVGHIGGDDFIVLSETEDPSKLCKYMIARFDGGVGAYHQGAKVSSVVTDRSGKAVEQDGVTLSLSLLQWDGENKLTTAMISQAAARLKKQAKAVSGSAYVAAEVPESI

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Crispr_ID: CP034437_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP034437_14

5924478-5924661

Orphan

Consensus_repeat	Method
TGAGAGAACGTATCTGTTCTCTC	CRISPRCasFinder

3 spacers

The CRISPR arrays of CP034437_14

>merge|CP034437|14|5924478-5924661|CRISPRCasFinder
TGAGAGAGCGTATATGTGCTCTCAGCTGCTGTTGGGGTTGAGGTTGGCGTTGAGAGAACGTATCTGTTCTCTCAGCGCCATTTTTGTGTGGTCTGCTGGTGCGCTCTGTTCTGAGAGAACGTATATGTTCTCTCGGTGGTTTTTGGGGTTAGTTTTCGTGCCGAGAGTACGTATTTGTTCTCTC

>CP034437|14|9|5924478-5924661|CRISPRCasFinder
TGAGAGAGCGTATATGTGCTCTC	AGCTGCTGTTGGGGTTGAGGTTGGCGT
TGAGAGAACGTATCTGTTCTCTC	AGCGCCATTTTTGTGTGGTCTGCTGGTGCGCTCTGTTC
TGAGAGAACGTATATGTTCTCTC	GGTGGTTTTTGGGGTTAGTTTTCGTGC
CGAGAGTACGTATTTGTTCTCTC

Protein	Signature genes	Signature genes Name	Protein_function
CP034437.1\|AZN42915.1\|5934131_5934920_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381296
CP034437.1\|AZN42908.1\|5924912_5926133_-\|Ger(x)C-family-spore-germination-protein	unknown	unknown	gnl\|CDD\|274338
CP034437.1\|AZN42902.1\|5916591_5917335_-\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
CP034437.1\|AZN42910.1\|5927145_5928693_-\|spore-germination-protein	unknown	unknown	gnl\|CDD\|377020
CP034437.1\|AZN42906.1\|5921472_5922228_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224320
CP034437.1\|AZN42909.1\|5926054_5927149_-\|spore-gernimation-protein	unknown	unknown	gnl\|CDD\|281794
CP034437.1\|AZN42901.1\|5916258_5916552_+\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42904.1\|5918594_5919545_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381316
CP034437.1\|AZN42916.1\|5934932_5935376_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42899.1\|5912212_5913748_-\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
CP034437.1\|AZN42914.1\|5933232_5934126_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP034437.1\|AZN42907.1\|5922494_5924432_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|269892
CP034437.1\|AZN42905.1\|5919562_5921476_-\|hypothetical-protein	unknown	unknown	unknown
CP034437.1\|AZN42917.1\|5935662_5937300_+\|spore-germination-protein	unknown	unknown	gnl\|CDD\|377020
CP034437.1\|AZN42900.1\|5913770_5914478_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
CP034437.1\|AZN43929.1\|5914629_5916093_-\|class-C-beta-lactamase-related-serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
CP034437.1\|AZN42912.1\|5929822_5932177_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225789
CP034437.1\|AZN42911.1\|5928857_5929718_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293837
CP034437.1\|AZN42903.1\|5917511_5918582_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
CP034437.1\|AZN42913.1\|5932332_5933172_-\|phytanoyl-CoA-dioxygenase	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP034437.1\|AZN42908.1\|5924912_5926133_-\|Ger(x)C-family-spore-germination-protein	gnl\|CDD\|274338	TIGR02887, Spore_germination_protein_B3, germination protein, Ger(x)C family. Members of this protein family are restricted to endospore-forming members of the Firmicutes lineage of bacteria, including the genera Bacillus, Clostridium, Thermoanaerobacter, Carboxydothermus, etc. Members are nearly all predicted lipoproteins and belong to probable transport operons, some of which have been characterized as crucial to germination in response to alanine. Members typically have been gene symbols gerKC, gerAC, gerYC, etc. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Sporulation and germination].	3.53283e-60
CP034437.1\|AZN42902.1\|5916591_5917335_-\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	4.33514e-31
CP034437.1\|AZN42915.1\|5934131_5934920_-\|aldo/keto-reductase	gnl\|CDD\|381296	cd06660, AKR_SF, Aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.	6.09143e-21
CP034437.1\|AZN42906.1\|5921472_5922228_-\|hypothetical-protein	gnl\|CDD\|224320	COG1402, COG1402, Uncharacterized protein, putative amidase [General function prediction only].	3.29895e-28
CP034437.1\|AZN42909.1\|5926054_5927149_-\|spore-gernimation-protein	gnl\|CDD\|281794	pfam03845, Spore_permease, Spore germination protein.	3.89936e-47
CP034437.1\|AZN42910.1\|5927145_5928693_-\|spore-germination-protein	gnl\|CDD\|377020	pfam03323, GerA, Bacillus/Clostridium GerA spore germination protein.	0
CP034437.1\|AZN42904.1\|5918594_5919545_-\|aldo/keto-reductase	gnl\|CDD\|381316	cd19090, AKR_AKR15A-like, AKR15A family of aldo-keto reductase and similar proteins. The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).	4.73915e-95
CP034437.1\|AZN42899.1\|5912212_5913748_-\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
CP034437.1\|AZN42914.1\|5933232_5934126_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.12022e-23
CP034437.1\|AZN42907.1\|5922494_5924432_+\|hypothetical-protein	gnl\|CDD\|269892	cd14791, GH36, glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	2.38981e-38
CP034437.1\|AZN42917.1\|5935662_5937300_+\|spore-germination-protein	gnl\|CDD\|377020	pfam03323, GerA, Bacillus/Clostridium GerA spore germination protein.	0
CP034437.1\|AZN42900.1\|5913770_5914478_-\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	3.35481e-20
CP034437.1\|AZN43929.1\|5914629_5916093_-\|class-C-beta-lactamase-related-serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	2.93753e-35
CP034437.1\|AZN42912.1\|5929822_5932177_+\|hypothetical-protein	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	1.21683e-59
CP034437.1\|AZN42911.1\|5928857_5929718_-\|hypothetical-protein	gnl\|CDD\|293837	cd16279, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry. Some members of this subgroup are named as octanoyltransferase (also known as lipoate-protein ligase B).	4.50137e-20
CP034437.1\|AZN42903.1\|5917511_5918582_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.54563e-18

>CP034437.1|AZN42907.1|5922494_5924432_+|hypothetical-protein
MKLQLGSPTADYFSGGKVPFSFVYGGELAGHSSMERFAMSEKSTTSEGVTVNERLYEDELTGLQCKVVSKSYSEGISEWVVFFRNPTEKSLPILEQVKAVDLQYELPYSSDAILHYSKGSSNQYDDFMPQRVQMKDRELHRFSPVGGRSSNGVLPFFNVQQEDQGLIIAIGWSGQWSAELTCPSHNRLTLRAGQAQLRLSLQPGEEIRLPSIVLVPWLGSRMDGQNKLRRFIMSHKTPKVDGTPITGPITVGSWGGTEAAVHLNRIRAVKELALPYSHYWVDAGWYGAADSDTSDEFTGEWYRQAGDWNYHRKYYPDGIKVVSDAVREAGMKFLLWMEPERAIYGKPITLEHPEWYVGKKVEGESVLLNLGQPEALEWLIGMISGLIAEHGIELFRQDFNFNPLPYWESLDTPDRIGAAEAHYVQGLYTFWDELLLRHPGLIIDNCASGGRRIDIETTSRSIPLWRSDVQCVPCDPIAAQTHGFGLSHWIPLSGTAARSSAPYDGRSILAAAAGLSPYFQADGNVVPDFPVDELRDRLQEYNRASTLFAGDFYPLTDCTISPQAWLAYQLDRPDLGQGIVAAFRRQESPFVTAVFQLQGIDTEANYELEDADTKEIQVIHGSALQSLQVEIGEYRQSKLYFYRKQ
>CP034437.1|AZN42906.1|5921472_5922228_-|hypothetical-protein
MYLTRMRPEQVREAVQNNLPLIMGSGVVEYHGPHLPIGTDAMIASHICAEVEKRIPCVVAPPLAFGPTMSWAAGPEDGEIDFDPAPFEAYAKELLKRLRMIGFKQIYIVQHHQGMDGLQALSLRHAAAELTREEALSWGHSWGWQDPSSLPNPNIFSTIQVAGIDTYLRYPADNPGPMPIGHAGKGETQLIQHIDPETVRIEALDTIEQSRLPEWLLDAKEADADEARFWLDLCVEGWIRHITEAGVGGEG
>CP034437.1|AZN42905.1|5919562_5921476_-|hypothetical-protein
MNRRAQTIVADMPFGQPPKWALLERQLIDLMNEAIDPLLEKYVHPDGSIMWPTKEDHVGVDALDDAYESFHNWPLFYLLGGADRLLDLSHKEFDAITEQFTRYDSGHGHPMVVKEYEQGYDWFHQGEGYLFFYLLCLADPANARNIERAKRFAGFYMNEDPDAPNYDERHNILKSAHTGSKGPAHRNFSGEPWLYEDWKKWYGLPFHDLPGVETVDDLKDYDKAALMGSAMKERQAYGDVAVNLAATTMLANAYLLTGEEKYKSWIRTYVDGWVERTEQNGGILPDNVGMSGKVGEHNGGKWYGGYYGWTWPHGWETVGDAAVIAGQNAMLLFQDASYLELPRSQVDQLIKLGVRDSGTLYVPHKKGDPFERAAYNCEPALKNEQGEMYVNDGWFEYLPMDARYIAHVWNMSRDESDLARLVTIRNSKTREWERVNISRKKDQGGHEQAWISYLQGDYPDYPEEILMYNIEQVYGRLQFMRDDTQDPSTYGDWYLQARNPVTAEGLTQLTLGAPQPDYNGGLLMASIRYEDLERGRPGLPADVGALVEHMDAEGLTVKLVNLSVSQKRELAIYAGAFGEHQFSSVAYKARGTADDGMEENIIENNMLEVTLLPGSEITLHLGVKRFVHAPTYKVGRL
>CP034437.1|AZN42904.1|5918594_5919545_-|aldo/keto-reductase
MDMAEERGQFKQTISRYWLRTAGGNRIPYGVGCAWLGRGAMDAETMDLEAAVLKLAYDSGVRYFDTSVAYGESERIVGHFLAQVPRESVFLASKVRVREDVTAKEAVVLAKLSLEQSLARMRTDYLDLYQVHDPNVLANVLAENGVLHMLLEAKERGVIRNIGLATRQHDLLAVAANHGQFDTILTYSDYTPVDPSAASLIAEASGLGLGVINASPLLTGLLCGPPPMEVEIPRGVPELELRQKRASELYELCAANGVSITDAALQFPARQSQIDITLSGPSRAADVTNTIASLERSIPESFWRQVEQWYNQLPQK
>CP034437.1|AZN42903.1|5917511_5918582_-|Gfo/Idh/MocA-family-oxidoreductase
MAMERDVHAEHGNGAASKPKRILVLGTEKLGEWSKRPYLEVAGVVDLYGEFERLPAEDRIWLDRYPVYADVDTALARSAAELAVIIVPNDCKNTIDAERKVLERGLDLVVQKLRLDSAEDVWELVQLSRRSGSGSGNGAKFIVGEFYRYLASIRTIKSLLQDPSVVGKVEYVVWSCTLPLTANAHNRWMSSYKHVTLEDLSYHHFGTLHYLLGFHPVTLYAQSYKPSWAKVGTLPIASMQAKTAEGYRLHYLTTWGSRAEPTDYLGDIRIEGERGTIELKSGRVFITGSDGVIREAELLPARYEGFFGIFDHLHDVWEGKDTRVDGSPYTIEQFEPVLRAMYSAVRSAETGEAVLL
>CP034437.1|AZN42902.1|5916591_5917335_-|phytanoyl-CoA-dioxygenase-family-protein
MIVTHKEVEQYNRDGFVMVKDLFTKNEVNRLIQEIEGGDRVAGTTYSADDSSGRKAKLAIWFELGSDVWSSVSICPRIINNVRILMGEDAAFFHGKVMLKEAKSGGAWEWHQDYGYWYDQGFIYPNMMSVFIALDPATRENGCLQVLRGSHKLGRLEHGKVGAQTGADPRRIHQVQDMFELMHCEMEPGTALFFHSNLLHASAPNMSEHHRRTFITCYNATSNPVLQGETLKYFGTCPVGSDDWLAN
>CP034437.1|AZN42901.1|5916258_5916552_+|hypothetical-protein
MKDDIISWIIGIGMLLAGHIIIRWYWQDIAAHTRQYKKEKQGGQLRWWWLDAGLILWDVFLGGFRPSLVIALILLLCGIGIVVVQVRKTVEMLMGYF
>CP034437.1|AZN43929.1|5914629_5916093_-|class-C-beta-lactamase-related-serine-hydrolase
MTRTELRLPRTTPESVGIPSQAISNLLDAWRESNLELHSMMIVRHGQVAAEGWWAPYEPQLSHMMFSLSKSFTSTAIGLAVAEGLLSLDDAVISFFPEESPEEPSANLRAMRIRHLLMMGTGHEVDTMQYLAVAEDGDWVRAFVQAPVEREPGTHFVYNSGATYMLSAIIQKVSGQKLLDYLQPRLLDPLGITEATWEACPRGIHTGGWGMTLTTESIAKFGQLYLQRGVWDDKRVLTEAWVNEATSKQINNGDDEANDWAQGYGYQFWRCRHGAYRGDGAFGQFCIVLPEKDTVIALTSGTNDMQGVLNGIWTHLLPALNDETSAAASTAEDAAALNSKLARLTLEPPRIIAEEASTESKVNGRRYVLEENSLQLTALTIQFEADAALVTIESSEGEFVLRCARGEWAEGRGIMPQGAPFQRGQNLRMMSSFTWSEPDKLTITARYIETPFSVKADYQFSEDELVVQQKVNVSFMPPELPTLRGRS
>CP034437.1|AZN42900.1|5913770_5914478_-|DNA-alkylation-repair-protein
MTYEEVMQHLAEMGSEQTKKTLVNHGAREPFYGVKVGDLKKLVKPVKKDQALALSLYDSGVSDAMYLAGLTVNPKTITKEQLQSWVRAAYWYLLAEYTVASVAAESPWARELAMEWIRSPEEMIAACGWSTYANYLSITVDEQLDMDEVRGLLHEVRDRIHIEQNRVRYTMNGFLISAAAYVRELHEEAIEIAEVVGKVHVNVGNTACKVPLAAEYITKMAGMGKIGIKRKTCIC
>CP034437.1|AZN42899.1|5912212_5913748_-|gluconokinase
MTMSYMMGVDIGTTSTKAVLFEENGTVVTSAHVEYPLYTPTPEIAEQNPEEIFAAVLSTIKQVMQGIDAGQVLFVSFSSAMHSVIPVDGDGKPLMNCITWADNRSAAWAKRLKEEMGGHAIYLRTGTPIHPMSPITKLLWLRHEKQDVFAHAARFISIKEYIFAKLFGAYIVDHSIASGTGMFNLEQMNWDDEALRITGVTADKLSAIVPTTHVQQGLIGVYAAAMGLKAETRFVVGASDGPLSNLGVGAVDPGVVAVTIGTSGAIRTIVDKPVTDPNGRYFCYALTENKWVIGGAVNNGGIIFRWLRDELAAAEVETAKRLGIDPYDMLTRIIEGVRPGSDGLIFHPYLTGERAPLWNPDARGSFFGLTLHHRKEHMMRAVLEGINYNLYSVLAALEESIGKPVRIHATGGFARSALWRQMMADVLDQDLIIPESFESSCLGAVVLGLMAIERADSLSIVTQMTGSNYAHTPNKEAAAQYRELLPIYLRLAGKLEEEYASIAEYQRKLNY
>CP034437.1|AZN42908.1|5924912_5926133_-|Ger(x)C-family-spore-germination-protein
MGAGICLSFLATRLYESGPSKGGDQMSRLCRITILVLGILLLPGCYDQMNLEDASIVLMLGLDVDENGKLMIYAQSPVFSKEAKEKSESVAVAADSVRLARSKFDAVLTGITTGGKLQTILIGTRLLQQQDWFKLLDMFYRMPKLTETPRVIIVDGAIKEIFAFKPADKPRLSLHMSKLIDTAHITNITVLTNMQELRRQMKEKGMTPSLSLIRKEKDEIFVKGTALLNKNDALVARLSLQESTLLLLLQDQIHGIPSLTMELKSTANSEDSDNENESTLKSAISFDIATYKRNIHSSMSNGKFRFDIDVQLNIVITDVQTENSNFNRDQKSTVEKMISAYFTKQFNGLIQKCQSKSVDPFGFGLYARAYQYKHWKAVQNEWEEAFSNADVRVNLKTSIKSFGVTE
>CP034437.1|AZN42909.1|5926054_5927149_-|spore-gernimation-protein
MKKYALNDITLFQYIFMIHGSQIGFGLLSLPTDLAKSAGTDGWISLLFGWALAVIASLFIVQVMKKHPDQTVYDLIPRYFGNVLGAIMNAGIAVYFLFGFFVAFVSLVGFFKIELLANTPNFMLVILFLLPTYMLARNKIRVLGRYAEISFWCFLWMALLYMYPLKDTHWLHLLPMLKEGWGPVLKATSTTGLSFLGFEICFVLYPFLKHKEKAAVGIIIANSMTLLIYMVVTVISFLFFSPDDITSYQYPTLKLLKVMEFRFLERVEIIALVAYVFLAIRVWTHYLYAGTFGLSKLAGMQDHKLFVKLTFIGMILFITFFKPSFLWMAHMLKHFGQFGWALAFVFPFLLLVYTSLVRQKGAIR
>CP034437.1|AZN42910.1|5927145_5928693_-|spore-germination-protein
MGFFRSILRGKRRRHKPSSPPPVHSGAAQPLVMDLETNIKELQARLSQSPDLVTRRIPIKASGERAALIYLDSLTDKVSINHDVLRPLMHETAVDPQIENIVTVGRMKTETDLYQIEKAILQGYSILLVENTGTAYLLCTHGWPQRAIEDPQLEASLKGAHQGFVETSSQNIALIRRYIPNREMKMIEMQVGERGMTTVSILYLADVANPEVLQELVERIKRVDIDAILSSGELEEYIEDNPYSPFPQFTSTERPDSVASQILQGRLAMVVDKSPEVLIGPANFAMFFQSVDDYSIRWQVSSFIRLLRFAAFFLTIFLPAFYIAVISYNFEVIPLKLLLSVGQSRQGVPFPPIVEALIMELTLEMLKEAGIRLPAPIGQTVGIVGAIVIGQATVQAGVVSNIMVIVVSLTALSSFIIPNNDMSAAIRLIRFPMMLAAFLYGLLGVGIGMLVVLGHLIALESLGTPYFSPFGPLRFSDMKDSIIRLPMWKMIKRPLSSNPIQQRRHGNGTNRGGNR
>CP034437.1|AZN42911.1|5928857_5929718_-|hypothetical-protein
MIFLGTGAAEGLPCYYCRCDYCNEVRKRRGKDIRTRSSFRIDGKHQIDFSPDIFAQMNSLGLDVFELEHLLITHTHEDHFDLAEIMVKDCAVDPHPRPLNIYLSKPALSWAERLLEGYSTHLTEEQRSELKSRYRLVPLEYYETYAMGELLVTPVKGSHRAFGEGELASNYLIVVQNGQTMLYACDTGWYSEETWAYLEGKKLDVLIMECTFGGRQDRGLHVEGHLDIPNFLLMLERMQAIGLIDGQTPIYATHINHKHHLLHDDMQSVFDQSGFNVQVAYDGLQI
>CP034437.1|AZN42912.1|5929822_5932177_+|hypothetical-protein
MNLELTAYISRRIVMNQSMTLNGKWKLYYGLEEGEMPAVLADVKARNWPAVEASVPGNVELDLVRAGVENDPYLGQNLYHFSKYEYYQWWFERDFQISEDLQGKNIAIKLHGLDTFGTIWINDTLVGTTDNMMIEHECDITPYVRFGESNHIAIRIESAMNKIRDKDFPVNLCMSERHDELVWLRKPPHSFGWDIAPRLLSAGIWRDIEIIVNEKTRLTEVYYATQQLQGNSAQMAVRYRFTTDKTYLNDFSIRIRGVCGEHSFEHEANTKFVSDGFSFDVPNPKLWWPKGYGDASLYEVTFVLLYKGQPVDSRTENIGIRILELKTAFELGDAGEFQIIANGIPIFAKGTNWVPLDALHSRDKERLPQAHDLLEDLGCNIVRCWGGNVYEDHEFFDLCDRRGIMVWQDFAMACAIYPQSEEFADMIRKEAISIVKKMRNHPSILLWAGDNEIDQLYYHKGYVLPHARNNRISREVLPNVVGSHDPFRTYLHSSPYIPEHIIGDLNVPEQHNWGPRDYFKGDFYKHTTAHFISEIGYHGCPAVSSIKKFISPDQLWPYSNNDEWDTHNTEYIPFEKRYYNRNELMASQVEILFGHVPDTLEEFALASQISQAEAKKFFVEMVRLRKWRRTGVIWWNALDCWPQFSDAVVDYYFNKKLAYHYLKRVQAPVCLMMSEIENWHHKVILGNDSLETGLVTYHVEDGDTGEILLQGQVMMKANENVEVGSIKTLEGKKRLYLLKWNFNTTEGANHYISGLVPFDINQYKNWLKTIEALPGAFSSDECYL
>CP034437.1|AZN42913.1|5932332_5933172_-|phytanoyl-CoA-dioxygenase
MMVKVGNRELELGGEHLTELRDSNDILHDFEALNKRIKEEGYLLLRGFHDREQVLKARRAVLEKMQNMGKLNRDTMLEDGVMADGTKTLFFGGTNEDLPELLNVLNGDHIMSFFDQLFGEKSLTYQYKWLRAVGKGDYTGAHYDIVYMGRGTHNLYTVWSPIGDVDYAMGGLAICLDSHKFDDLKKSYGTKDSDNDGVGHYTDDPLVITNKYGGKWATTEFRAGDIIIFGMFLMHCSLENTTNQYRLSVDTRYQSSLETVDERWSGKKPRGHFKAVGSN
>CP034437.1|AZN42914.1|5933232_5934126_+|AraC-family-transcriptional-regulator
MEKDHNNMYNRTKIKAQPIFPSRGASSEMSYINVPYQLTETQYPPPCQFKSIWKVQANSSYKVAHPQGLSTPGLFVTLEGKGKFVQGNEEKMLTAGTLLFVEEKLPCSYDCADDNWKFYFIHFDQLPMIRHLGLPVGERITTAKINEAARLCERLIEILIIQTIGYEYAANLVLQELLLLFAGDRIVKVSSNLDLGEILLQMHRNIAQPFRSEDFIRHSGLSRTAFFSQFREMTGKSPNQYMLELKLASAKASLESTNTSVKDIAASLHFYDEFHFSKSFKKRYGISPRMYRKLGNS
>CP034437.1|AZN42915.1|5934131_5934920_-|aldo/keto-reductase
MSCMPNLSKLGLGGHTFIEELGNDPLASFEEQCTIVRECLDNGIQLIDTTYYQERVALGNVLRALGRRQEVQIMAWNFFNLPGQSDKLVGYSSYEPHHIDVMLSELQTDFIDVLVIHTHDDEHKLLQEIELAKQWVEQGKVGTVGLGMAEPAHLNRLPADHPVTHILAPYNIAHQRTKETFVIAKEMGLTTVALSPFVRGWKLDEINSEQAADLLLRWVSEQQVVDRVIVSMRKADWVHTNLQATQRGTLTEEENRLIKEWM
>CP034437.1|AZN42916.1|5934932_5935376_-|hypothetical-protein
MAIMNPDRVSAHLQSCRITRIECYRFDPEFGRKLKLREEADVCGLIAISTTTGVVGFKEFAIPTRSLAGDLAMWAALFQRLKGLSLVDCIGYSQLKQEAWGQVRVELMESALMNIVEQINLGLDDIELPGKWDRAFLFHHAQEYVSF
>CP034437.1|AZN42917.1|5935662_5937300_+|spore-germination-protein
MSRASKHSAPHSHFMDNFESSLTPYPYIGPGGMRMVFFQSKQSRSKSAPPLVKSSSHPSPLAATLEANMQTVRQRLSDPLDLKFHDLQLSANSGCLAYLDTLVDTDIIHEQILLPLAKGLDLPIRQQLTSTDVQIRHDIDNVIQDLLSGCAVLFLRDQDEAYSVNVPSHQLRSIEEPSNEKVIRGTHDGLIESLSVNLHLIRKRLETSQLVIRSFEVGDEVQSKLALLYMQDIANPEMIAKATHRLSSIHADLFKSSGYVEQLIEDSWLSPFPQILSTERADRIAYNLIEGRAAVITDGSPTALVFPVNLFTFFQSPDDYNSRWHIGSFYRMLRILSFFIASMLPAIYIAIIAFHFEVLPFKLVVAFKQSVELVPFPPLIEAMLMELTIELIREAGIRMPTSIGPVIGIVGGIIIGQAAVEANLVSNVMVIVVAVTATASFTITSNEMVTSLRLLRFPFMFAAASFGFLGISICLSVVLMHLCALESFGTPYLAPLSTGKWSDMRDAIFRFPLWLLQRRPRDPLPIKTKRSTSMRGWLSDEPDDY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP034437_10	10.7\|3681133\|19\|CP034437\|CRISPRCasFinder	3681133-3681151	19	CP034437.1	3681205-3681223	0	1.0
CP034437_10	10.8\|3681178\|19\|CP034437\|CRISPRCasFinder	3681178-3681196	19	CP034437.1	3681214-3681232	0	1.0
CP034437_10	10.1\|3680854\|19\|CP034437\|CRISPRCasFinder	3680854-3680872	19	CP034437.1	32553-32571	2	0.895
CP034437_10	10.1\|3680854\|19\|CP034437\|CRISPRCasFinder	3680854-3680872	19	CP034437.1	4744269-4744287	2	0.895
CP034437_10	10.6\|3681088\|19\|CP034437\|CRISPRCasFinder	3681088-3681106	19	CP034437.1	3681232-3681250	2	0.895
CP034437_10	10.7\|3681133\|19\|CP034437\|CRISPRCasFinder	3681133-3681151	19	CP034437.1	32823-32841	2	0.895
CP034437_10	10.7\|3681133\|19\|CP034437\|CRISPRCasFinder	3681133-3681151	19	CP034437.1	33021-33039	2	0.895
CP034437_10	10.7\|3681133\|19\|CP034437\|CRISPRCasFinder	3681133-3681151	19	CP034437.1	4743594-4743612	2	0.895

1. spacer 10.7|3681133|19|CP034437|CRISPRCasFinder matches to position: 3681205-3681223, mismatch: 0, identity: 1.0

aggagcgaccggaggaacg	CRISPR spacer
aggagcgaccggaggaacg	Protospacer
*******************

2. spacer 10.8|3681178|19|CP034437|CRISPRCasFinder matches to position: 3681214-3681232, mismatch: 0, identity: 1.0

cggaggaacgggggcgacc	CRISPR spacer
cggaggaacgggggcgacc	Protospacer
*******************

3. spacer 10.1|3680854|19|CP034437|CRISPRCasFinder matches to position: 32553-32571, mismatch: 2, identity: 0.895

tggagcaacgggggcaacg	CRISPR spacer
tggagcaacgggagccacg	Protospacer
************.** ***

4. spacer 10.1|3680854|19|CP034437|CRISPRCasFinder matches to position: 4744269-4744287, mismatch: 2, identity: 0.895

tggagcaacgggggcaacg	CRISPR spacer
tggagcaacgggagcgacg	Protospacer
************.**.***

5. spacer 10.6|3681088|19|CP034437|CRISPRCasFinder matches to position: 3681232-3681250, mismatch: 2, identity: 0.895

cgggggaaccggggcgaca	CRISPR spacer
cggaggaaccggggcaaca	Protospacer
***.***********.***

6. spacer 10.7|3681133|19|CP034437|CRISPRCasFinder matches to position: 32823-32841, mismatch: 2, identity: 0.895

aggagcgaccggaggaacg	CRISPR spacer
aggagcgacgggagcaacg	Protospacer
********* **** ****

7. spacer 10.7|3681133|19|CP034437|CRISPRCasFinder matches to position: 33021-33039, mismatch: 2, identity: 0.895

aggagcgaccggaggaacg	CRISPR spacer
aggagcgacgggagcaacg	Protospacer
********* **** ****

8. spacer 10.7|3681133|19|CP034437|CRISPRCasFinder matches to position: 4743594-4743612, mismatch: 2, identity: 0.895

aggagcgaccggaggaacg	CRISPR spacer
aggagcgacaggagcaacg	Protospacer
********* **** ****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP034437_4	4.1\|1557811\|25\|CP034437\|CRISPRCasFinder	1557811-1557835	25	NZ_CP038146	Streptomyces sp. S501 plasmid unnamed, complete sequence	185090-185114	4	0.84
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NC_003078	Sinorhizobium meliloti 1021 plasmid pSymB, complete sequence	130588-130615	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP019586	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymB, complete sequence	133310-133337	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021799	Sinorhizobium meliloti strain USDA1106 plasmid psymB, complete sequence	198125-198152	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021828	Sinorhizobium meliloti strain KH35c plasmid psymB, complete sequence	1380562-1380589	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP019484	Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence	340353-340380	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP019487	Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence	127949-127976	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NC_020560	Sinorhizobium meliloti 2011 plasmid pSymB, complete sequence	130588-130615	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NC_017326	Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence	1561568-1561595	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP009146	Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence	1546512-1546539	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NC_018701	Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence	1594089-1594116	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021802	Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence	192985-193012	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021820	Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence	258092-258119	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021831	Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence	177759-177786	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021814	Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence	1489679-1489706	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021810	Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence	717986-718013	5	0.821
CP034437_10	10.4\|3680989\|28\|CP034437\|CRISPRCasFinder	3680989-3681016	28	NZ_CP021218	Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence	82699-82726	5	0.821
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	HQ316581	Vibrio phage martha 12B12 genomic sequence	5905-5931	5	0.815
CP034437_5	5.1\|1814704\|58\|CP034437\|CRISPRCasFinder	1814704-1814761	58	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	900256-900313	6	0.897
CP034437_5	5.1\|1814704\|58\|CP034437\|CRISPRCasFinder	1814704-1814761	58	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1553265-1553322	6	0.897
CP034437_8	8.1\|2451516\|28\|CP034437\|CRISPRCasFinder	2451516-2451543	28	MN693997	Marine virus AFVG_250M1029, complete genome	2535-2562	6	0.786
CP034437_8	8.1\|2451516\|28\|CP034437\|CRISPRCasFinder	2451516-2451543	28	MN694761	Marine virus AFVG_250M1028, complete genome	35826-35853	6	0.786
CP034437_9	9.3\|3594821\|29\|CP034437\|CRT	3594821-3594849	29	NZ_CP026424	Acinetobacter sp. ACNIH1 plasmid pACI-148e, complete sequence	8862-8890	6	0.793
CP034437_13	13.1\|5268019\|26\|CP034437\|CRISPRCasFinder	5268019-5268044	26	NZ_CP022280	Escherichia coli strain STEC299 plasmid pSTEC299_1, complete sequence	4386-4411	6	0.769
CP034437_13	13.1\|5268019\|26\|CP034437\|CRISPRCasFinder	5268019-5268044	26	NZ_CP046008	Escherichia coli strain 1919D62 plasmid p1919D62-2, complete sequence	87812-87837	6	0.769
CP034437_13	13.1\|5268019\|26\|CP034437\|CRISPRCasFinder	5268019-5268044	26	NZ_CP046005	Escherichia coli strain 1919D3 plasmid p1919D3-2, complete sequence	68378-68403	6	0.769
CP034437_13	13.1\|5268019\|26\|CP034437\|CRISPRCasFinder	5268019-5268044	26	NZ_CP027106	Escherichia coli strain RM14721 plasmid pRM14721, complete sequence	8391-8416	6	0.769
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	NZ_CP022999	Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence	1346978-1347004	6	0.778
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	NC_020062	Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence	819923-819949	6	0.778
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	MN234234	Arthrobacter phage Lymara, complete genome	40458-40484	6	0.778
CP034437_14	14.3\|5924612\|27\|CP034437\|CRISPRCasFinder	5924612-5924638	27	CP011075	Brevibacillus laterosporus strain B9 plasmid unnamed1, complete sequence	533326-533352	6	0.778
CP034437_2	2.4\|1305916\|30\|CP034437\|CRT	1305916-1305945	30	NZ_CP035710	Sphaerotilus natans subsp. sulfidivorans strain D-507 plasmid pSna507_unt10, complete sequence	232010-232039	7	0.767
CP034437_3	3.3\|1510577\|28\|CP034437\|PILER-CR	1510577-1510604	28	NZ_CP031226	Pseudomonas amygdali pv. lachrymans str. M301315 plasmid pMPPla107, complete sequence	645183-645210	7	0.75
CP034437_3	3.3\|1510577\|28\|CP034437\|PILER-CR	1510577-1510604	28	NC_020051	Gloeocapsa sp. PCC 7428 plasmid pGLO7428.02, complete sequence	74667-74694	7	0.75
CP034437_9	9.3\|3594821\|29\|CP034437\|CRT	3594821-3594849	29	CP019145	Acinetobacter lwoffii strain ZS207 plasmid pZS-3, complete sequence	8457-8485	7	0.759
CP034437_12	12.3\|4941662\|28\|CP034437\|CRISPRCasFinder	4941662-4941689	28	NZ_CP014002	Synechococcus sp. PCC 73109 plasmid unnamed4, complete sequence	27557-27584	7	0.75
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	NZ_CP012107	Bacillus thuringiensis strain HS18-1 plasmid pHS18-8, complete sequence	7977-8003	7	0.741
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	NZ_CP007625	Bacillus pseudomycoides strain 219298 plasmid unnamed, complete sequence	247930-247956	7	0.741
CP034437_14	14.1\|5924501\|27\|CP034437\|CRISPRCasFinder	5924501-5924527	27	NZ_CP009647	Bacillus pseudomycoides strain BTZ plasmid pBTZ_4, complete sequence	8768-8794	7	0.741
CP034437_7	7.3\|2160803\|32\|CP034437\|CRT	2160803-2160834	32	AP018320	Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome	270315-270346	10	0.688
CP034437_7	7.3\|2160803\|32\|CP034437\|CRT	2160803-2160834	32	NZ_CP025811	Sulfitobacter sp. SK025 plasmid unnamed3, complete sequence	80108-80139	11	0.656
CP034437_7	7.3\|2160803\|32\|CP034437\|CRT	2160803-2160834	32	NZ_CP018078	Sulfitobacter sp. AM1-D1 plasmid unnamed2, complete sequence	93851-93882	11	0.656

1. spacer 4.1|1557811|25|CP034437|CRISPRCasFinder matches to NZ_CP038146 (Streptomyces sp. S501 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

tagcggaaaaccggcaattcggccc	CRISPR spacer
acgcggaaaaccggcagttcgggcc	Protospacer
  **************.***** **

2. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NC_003078 (Sinorhizobium meliloti 1021 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

3. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP019586 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

4. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021799 (Sinorhizobium meliloti strain USDA1106 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

5. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021828 (Sinorhizobium meliloti strain KH35c plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

6. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP019484 (Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

7. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP019487 (Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

8. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NC_020560 (Sinorhizobium meliloti 2011 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

9. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NC_017326 (Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

10. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP009146 (Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

11. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NC_018701 (Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

12. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021802 (Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

13. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021820 (Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

14. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021831 (Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

15. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021814 (Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

16. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021810 (Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

17. spacer 10.4|3680989|28|CP034437|CRISPRCasFinder matches to NZ_CP021218 (Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.821

aggcgaccctggaatagccggggcggca	CRISPR spacer
aggcgaccctggcagagccggggccggc	Protospacer
************ * ********* *

18. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to HQ316581 (Vibrio phage martha 12B12 genomic sequence) position: , mismatch: 5, identity: 0.815

agctgctgttggggttgaggttggcgt	CRISPR spacer
ttctgctgatgcggttgaggttggcga	Protospacer
  ****** ** **************

19. spacer 5.1|1814704|58|CP034437|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.897

gtaatcagtaggtcgtgggttcgactcctatcgccggcaccatttttacatgagccat-	CRISPR spacer
gtaatcagtaggtcgtgggttcgactcctatcgccggcaccatgttt-catggaggatt	Protospacer
******************************************* *** ****..  **

20. spacer 5.1|1814704|58|CP034437|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.897

gtaatcagtaggtcgtgggttcgactcctatcgccggcaccatttttacatgagccat-	CRISPR spacer
gtaatcagtaggtcgtgggttcgactcctatcgccggcaccatgttt-catggaggatt	Protospacer
******************************************* *** ****..  **

21. spacer 8.1|2451516|28|CP034437|CRISPRCasFinder matches to MN693997 (Marine virus AFVG_250M1029, complete genome) position: , mismatch: 6, identity: 0.786

tgctgcagcaaacaacactgctaaagca	CRISPR spacer
tgctgcatcaaacaacactcctagttct	Protospacer
******* *********** ***.  *

22. spacer 8.1|2451516|28|CP034437|CRISPRCasFinder matches to MN694761 (Marine virus AFVG_250M1028, complete genome) position: , mismatch: 6, identity: 0.786

tgctgcagcaaacaacactgctaaagca	CRISPR spacer
tgctgcatcaaacaacactcctagttct	Protospacer
******* *********** ***.  *

23. spacer 9.3|3594821|29|CP034437|CRT matches to NZ_CP026424 (Acinetobacter sp. ACNIH1 plasmid pACI-148e, complete sequence) position: , mismatch: 6, identity: 0.793

caaaaacaccgaaaaaacaatctgagaga	CRISPR spacer
caaacacactgaaaaaacaatcttaaatg	Protospacer
**** ****.************* *.* .

24. spacer 13.1|5268019|26|CP034437|CRISPRCasFinder matches to NZ_CP022280 (Escherichia coli strain STEC299 plasmid pSTEC299_1, complete sequence) position: , mismatch: 6, identity: 0.769

acgaccatatttgccgtgtaggattt	CRISPR spacer
gcagccatatttgccgtgtaggagcc	Protospacer
.*..******************* ..

25. spacer 13.1|5268019|26|CP034437|CRISPRCasFinder matches to NZ_CP046008 (Escherichia coli strain 1919D62 plasmid p1919D62-2, complete sequence) position: , mismatch: 6, identity: 0.769

acgaccatatttgccgtgtaggattt	CRISPR spacer
gcagccatatttgccgtgtaggagcc	Protospacer
.*..******************* ..

26. spacer 13.1|5268019|26|CP034437|CRISPRCasFinder matches to NZ_CP046005 (Escherichia coli strain 1919D3 plasmid p1919D3-2, complete sequence) position: , mismatch: 6, identity: 0.769

acgaccatatttgccgtgtaggattt	CRISPR spacer
gcagccatatttgccgtgtaggagcc	Protospacer
.*..******************* ..

27. spacer 13.1|5268019|26|CP034437|CRISPRCasFinder matches to NZ_CP027106 (Escherichia coli strain RM14721 plasmid pRM14721, complete sequence) position: , mismatch: 6, identity: 0.769

acgaccatatttgccgtgtaggattt	CRISPR spacer
gcagccatatttgccgtgtaggagcc	Protospacer
.*..******************* ..

28. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to NZ_CP022999 (Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence) position: , mismatch: 6, identity: 0.778

agctgctgttggggttgaggttggcgt	CRISPR spacer
tgctgctgatggggttgagtttgggca	Protospacer
 ******* ********** ****

29. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to NC_020062 (Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence) position: , mismatch: 6, identity: 0.778

agctgctgttggggttgaggttggcgt	CRISPR spacer
tgctgctgatggggttgagtttgggta	Protospacer
 ******* ********** ****

30. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to MN234234 (Arthrobacter phage Lymara, complete genome) position: , mismatch: 6, identity: 0.778

agctgctgttggggttgaggttggcgt	CRISPR spacer
gtgggctgttggtgttgcggttggcgt	Protospacer
.   ******** **** *********

31. spacer 14.3|5924612|27|CP034437|CRISPRCasFinder matches to CP011075 (Brevibacillus laterosporus strain B9 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

ggtggtttttggggttagttttcgtgc	CRISPR spacer
atcggttttttgggttagttttcctga	Protospacer
. .******* ************ **

32. spacer 2.4|1305916|30|CP034437|CRT matches to NZ_CP035710 (Sphaerotilus natans subsp. sulfidivorans strain D-507 plasmid pSna507_unt10, complete sequence) position: , mismatch: 7, identity: 0.767

gctctcggcagccggggaaggggtaatcac-	CRISPR spacer
gctctcggcggccggggaa-ggctatctgcg	Protospacer
*********.********* ** ** ...*

33. spacer 3.3|1510577|28|CP034437|PILER-CR matches to NZ_CP031226 (Pseudomonas amygdali pv. lachrymans str. M301315 plasmid pMPPla107, complete sequence) position: , mismatch: 7, identity: 0.75

agtttgaattttgcgcgaatctggcgct	CRISPR spacer
ttttagcattttgcgcgaatctggctgg	Protospacer
  ** * ******************

34. spacer 3.3|1510577|28|CP034437|PILER-CR matches to NC_020051 (Gloeocapsa sp. PCC 7428 plasmid pGLO7428.02, complete sequence) position: , mismatch: 7, identity: 0.75

agtttgaattttgcgcgaatctggcgct	CRISPR spacer
agtttgagttttgcgcgattctgcatag	Protospacer
*******.********** ****

35. spacer 9.3|3594821|29|CP034437|CRT matches to CP019145 (Acinetobacter lwoffii strain ZS207 plasmid pZS-3, complete sequence) position: , mismatch: 7, identity: 0.759

caaaaacaccgaaaaaacaatctgagaga	CRISPR spacer
caaacacactgaaaaaacaatcttaagcg	Protospacer
**** ****.************* *.. .

36. spacer 12.3|4941662|28|CP034437|CRISPRCasFinder matches to NZ_CP014002 (Synechococcus sp. PCC 73109 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.75

gtatacgattgctgcgtctccggctatc	CRISPR spacer
cacaattattgctgcgtctccggcaatc	Protospacer
    *. ***************** ***

37. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to NZ_CP012107 (Bacillus thuringiensis strain HS18-1 plasmid pHS18-8, complete sequence) position: , mismatch: 7, identity: 0.741

agctgctgttggggttgaggttggcgt	CRISPR spacer
ctttgcttttggggttgaggttggttc	Protospacer
  .**** ****************. .

38. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to NZ_CP007625 (Bacillus pseudomycoides strain 219298 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.741

agctgctgttggggttgaggttggcgt	CRISPR spacer
gtttgcttttggggttgaggttggttc	Protospacer
. .**** ****************. .

39. spacer 14.1|5924501|27|CP034437|CRISPRCasFinder matches to NZ_CP009647 (Bacillus pseudomycoides strain BTZ plasmid pBTZ_4, complete sequence) position: , mismatch: 7, identity: 0.741

agctgctgttggggttgaggttggcgt	CRISPR spacer
gtttgcttttggggttgaggttggttc	Protospacer
. .**** ****************. .

40. spacer 7.3|2160803|32|CP034437|CRT matches to AP018320 (Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome) position: , mismatch: 10, identity: 0.688

caacgaaaatctccaaaaaccagcgcgagagc	CRISPR spacer
aaaccaaaatctacaaaaaccagcaaaactag	Protospacer
 *** ******* ***********. .*  .

41. spacer 7.3|2160803|32|CP034437|CRT matches to NZ_CP025811 (Sulfitobacter sp. SK025 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.656

caacgaaaatctccaaaaaccagcgcgagagc	CRISPR spacer
ggttcaaaatctccaaaatccagcccgaatat	Protospacer
 . . ************* ***** ***. ..

42. spacer 7.3|2160803|32|CP034437|CRT matches to NZ_CP018078 (Sulfitobacter sp. AM1-D1 plasmid unnamed2, complete sequence) position: , mismatch: 11, identity: 0.656

caacgaaaatctccaaaaaccagcgcgagagc	CRISPR spacer
ggttcaaaatctccaaaatccagcccgaatat	Protospacer
 . . ************* ***** ***. ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1639364 : 1652971

Mollivirus(20.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZN43580.1\|1639364_1640240_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.4e-24	32.0
AZN39514.1\|1640833_1641319_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	4.7e-22	42.8
AZN39515.1\|1641315_1642497_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AZN39516.1\|1642502_1643798_+	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	2.2e-21	27.4
AZN39517.1\|1643988_1644876_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	6.4e-41	33.0
AZN39518.1\|1645183_1645426_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FJ99	Synechococcus_phage	1.8e-06	36.4
AZN39519.1\|1645429_1646125_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AZN39520.1\|1646102_1648346_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.6e-157	41.6
AZN39521.1\|1648330_1649809_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.4e-56	34.4
AZN39522.1\|1650012_1651056_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.5e-70	46.7
AZN39523.1\|1651055_1651685_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.7e-28	37.8
AZN39524.1\|1651789_1652971_+	phosphoribosylaminoimidazolecarboxamide formyltransferase	S4VT61	Pandoravirus	3.6e-15	24.3

DBSCAN-SWA_2

3132623 : 3141362

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZN40670.1\|3132623_3133055_+	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	4.1e-17	41.2
AZN40671.1\|3133573_3134692_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	6.6e-51	35.3
AZN40672.1\|3134732_3135413_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.1e-37	44.1
AZN40673.1\|3135433_3136654_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.1e-119	54.1
AZN40674.1\|3136732_3137203_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.3e-40	54.3
AZN40675.1\|3137292_3138075_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	2.8e-08	36.6
AZN40676.1\|3138043_3138682_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	6.3e-14	29.0
AZN40677.1\|3138766_3139444_+	DUF2953 domain-containing protein	NA	NA	NA	NA
AZN40678.1\|3139527_3139983_+	sporulation protein YtfJ	NA	NA	NA	NA
AZN40679.1\|3140135_3141362_+	D-alanyl-D-alanine carboxypeptidase	A0A1P8VVG5	Erythrobacter_phage	8.9e-09	33.3

DBSCAN-SWA_3

4686647 : 4695207

Bacillus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZN41960.1\|4686647_4687511_-	acyltransferase	M1I6H3	Paramecium_bursaria_Chlorella_virus	1.0e-06	23.2
AZN41961.1\|4687533_4688889_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.5e-28	31.4
AZN41962.1\|4688885_4689584_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.9e-32	33.8
AZN41963.1\|4689654_4691274_-	serine/threonine protein kinase	A0A2P1EMR8	Moumouvirus	5.6e-19	27.2
AZN43831.1\|4691387_4692356_-	SAM-dependent methyltransferase	NA	NA	NA	NA
AZN41964.1\|4692400_4693183_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	1.5e-14	27.7
AZN41965.1\|4693213_4693519_-	cell division protein FtsJ	A0A0A0RP18	Bacillus_phage	6.4e-09	42.7
AZN41966.1\|4693511_4694357_-	deoxyribonuclease IV	A0A146JI69	Tokyovirus	4.9e-14	28.7
AZN41967.1\|4694367_4695207_-	Fpg/Nei family DNA glycosylase	A0A127AWE5	Bacillus_phage	1.7e-06	26.4

DBSCAN-SWA_4

6555747 : 6562780

Thermus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZN43971.1\|6555747_6556533_-	DNA replication protein	S6B1M2	Thermus_phage	3.3e-57	51.0
AZN43377.1\|6556495_6557437_-	HTH domain-containing protein	S6BFM4	Thermus_phage	8.6e-36	33.4
AZN43378.1\|6557464_6558085_-	3'-5' exonuclease	A0A0N9SJX9	Paenibacillus_phage	2.2e-16	36.1
AZN43379.1\|6558059_6558299_-	hypothetical protein	NA	NA	NA	NA
AZN43380.1\|6558298_6559147_-	recombination protein RecT	S6AVW6	Thermus_phage	1.5e-76	58.2
AZN43381.1\|6559150_6560110_-	hypothetical protein	S6C475	Thermus_phage	1.5e-75	47.6
AZN43382.1\|6560442_6560706_-	hypothetical protein	NA	NA	NA	NA
AZN43383.1\|6560702_6560912_-	hypothetical protein	NA	NA	NA	NA
AZN43384.1\|6560925_6561249_-	XRE family transcriptional regulator	NA	NA	NA	NA
AZN43385.1\|6561728_6561935_-	hypothetical protein	NA	NA	NA	NA
AZN43386.1\|6561948_6562206_-	XRE family transcriptional regulator	NA	NA	NA	NA
AZN43387.1\|6562369_6562780_+	XRE family transcriptional regulator	S5MUA5	Brevibacillus_phage	1.6e-07	38.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP034437

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection