CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP027725	Pseudomonas orientalis strain R2-66-08W chromosome, complete genome	9 crisprs	DEDDh,DinG,csa3,cas3,WYL	2	0	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP027725_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_1

49848-49943

Orphan

Consensus_repeat	Method
AAATGTGGGAGGGGGCTTGCCCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_1

>merge|CP027725|1|49848-49943|CRISPRCasFinder
AAATGTGGGAGGGGGCTTGCCCCCGTGACGGCCGGACAGCCGACGCGGTTCTACCTGACGCTCCGATGTCCAAATGTGGGAGGGGGCTTGCCCCCG

>CP027725|1|1|49848-49943|CRISPRCasFinder
AAATGTGGGAGGGGGCTTGCCCCCG	TGACGGCCGGACAGCCGACGCGGTTCTACCTGACGCTCCGATGTCC
AAATGTGGGAGGGGGCTTGCCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE92211.1\|55741_56473_+\|Carbonic-anhydrase,-beta-class	unknown	unknown	gnl\|CDD\|238449
CP027725.1\|AZE92202.1\|46205_46865_-\|Phosphoglycolate-phosphatase	unknown	unknown	gnl\|CDD\|319798
CP027725.1\|AZE92201.1\|45077_46121_+\|aminopeptidase	unknown	unknown	gnl\|CDD\|378359
CP027725.1\|AZE92214.1\|59329_60376_+\|Cytochrome-c-oxidase-polypeptide-II	unknown	unknown	gnl\|CDD\|224537
CP027725.1\|AZE92213.1\|58242_58878_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE92207.1\|50534_51287_+\|Gluconate-2-dehydrogenase,-membrane-bound,-gamma-subunit	unknown	unknown	gnl\|CDD\|379295
CP027725.1\|AZE92197.1\|42461_43463_-\|Luciferase-like-monooxygenase-YhbW	unknown	unknown	gnl\|CDD\|274646
CP027725.1\|AZE92200.1\|44552_44975_-\|Phosphonate-ABC-transporter-phosphate-binding-periplasmic-component	unknown	unknown	unknown
CP027725.1\|AZE92204.1\|47505_49557_+\|Oligopeptidase-A	unknown	unknown	gnl\|CDD\|341051
CP027725.1\|AZE92209.1\|53086_54385_+\|Gluconate-2-dehydrogenase,-membrane-bound,-cytochrome-c	unknown	unknown	gnl\|CDD\|224921
CP027725.1\|AZE92215.1\|60434_62021_+\|Cytochrome-c-oxidase-polypeptide-I	unknown	unknown	gnl\|CDD\|238833
CP027725.1\|AZE92205.1\|49553_49829_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|312883
CP027725.1\|AZE92216.1\|62017_62167_+\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE92208.1\|51283_53074_+\|Gluconate-2-dehydrogenase,-membrane-bound,-flavoprotein	unknown	unknown	gnl\|CDD\|225186
CP027725.1\|AZE92199.1\|44312_44552_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369019
CP027725.1\|AZE92212.1\|56558_58106_+\|Na(+)-dependent-bicarbonate-transporter-BicA	unknown	unknown	gnl\|CDD\|223732
CP027725.1\|AZE92203.1\|46861_47404_-\|Protein-YrdA	unknown	unknown	gnl\|CDD\|100051
CP027725.1\|AZE92210.1\|54455_55514_+\|Radical-SAM-domain-protein	unknown	unknown	gnl\|CDD\|275263
CP027725.1\|AZE92198.1\|43677_44109_+\|Peroxiredoxin-OsmC	unknown	unknown	gnl\|CDD\|274650
CP027725.1\|AZE92196.1\|42089_42314_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369019

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE92211.1\|55741_56473_+\|Carbonic-anhydrase,-beta-class	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	6.37145e-101
CP027725.1\|AZE92202.1\|46205_46865_-\|Phosphoglycolate-phosphatase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.75987e-104
CP027725.1\|AZE92201.1\|45077_46121_+\|aminopeptidase	gnl\|CDD\|378359	pfam10023, Aminopep, Putative aminopeptidase. This family of bacterial proteins has a conserved HEXXH motif, suggesting that members are putative peptidases of zincin fold.	0
CP027725.1\|AZE92214.1\|59329_60376_+\|Cytochrome-c-oxidase-polypeptide-II	gnl\|CDD\|224537	COG1622, CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion].	6.26234e-73
CP027725.1\|AZE92207.1\|50534_51287_+\|Gluconate-2-dehydrogenase,-membrane-bound,-gamma-subunit	gnl\|CDD\|379295	pfam13618, Gluconate_2-dh3, Gluconate 2-dehydrogenase subunit 3. This family corresponds to subunit 3 of the Gluconate 2-dehydrogenase enzyme that catalyzes the conversion of gluconate to 2-dehydro-D-gluconate EC:1.1.99.3.	1.15083e-38
CP027725.1\|AZE92197.1\|42461_43463_-\|Luciferase-like-monooxygenase-YhbW	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	0
CP027725.1\|AZE92204.1\|47505_49557_+\|Oligopeptidase-A	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
CP027725.1\|AZE92209.1\|53086_54385_+\|Gluconate-2-dehydrogenase,-membrane-bound,-cytochrome-c	gnl\|CDD\|224921	COG2010, CccA, Cytochrome c, mono- and diheme variants [Energy production and conversion].	7.15146e-14
CP027725.1\|AZE92215.1\|60434_62021_+\|Cytochrome-c-oxidase-polypeptide-I	gnl\|CDD\|238833	cd01663, Cyt_c_Oxidase_I, Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.	0
CP027725.1\|AZE92205.1\|49553_49829_+\|hypothetical-protein	gnl\|CDD\|312883	pfam09526, DUF2387, Probable metal-binding protein (DUF2387). Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.	1.03404e-40
CP027725.1\|AZE92208.1\|51283_53074_+\|Gluconate-2-dehydrogenase,-membrane-bound,-flavoprotein	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	9.14833e-82
CP027725.1\|AZE92199.1\|44312_44552_+\|hypothetical-protein	gnl\|CDD\|369019	pfam06649, DUF1161, Protein of unknown function (DUF1161). This family consists of several short, hypothetical bacterial proteins of unknown function.	3.91624e-17
CP027725.1\|AZE92212.1\|56558_58106_+\|Na(+)-dependent-bicarbonate-transporter-BicA	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	6.59718e-104
CP027725.1\|AZE92203.1\|46861_47404_-\|Protein-YrdA	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	7.20027e-80
CP027725.1\|AZE92210.1\|54455_55514_+\|Radical-SAM-domain-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	5.07649e-22
CP027725.1\|AZE92198.1\|43677_44109_+\|Peroxiredoxin-OsmC	gnl\|CDD\|274650	TIGR03562, osmo_induc_OsmC, peroxiredoxin, OsmC subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein OsmC, or osmotically induced protein C. The member from Thermus thermophilus was shown to have hydroperoxide peroxidase activity. In many species, this protein is induced by stress and helps resist oxidative stress. [Cellular processes, Detoxification].	1.78109e-79
CP027725.1\|AZE92196.1\|42089_42314_+\|hypothetical-protein	gnl\|CDD\|369019	pfam06649, DUF1161, Protein of unknown function (DUF1161). This family consists of several short, hypothetical bacterial proteins of unknown function.	3.49804e-22

>CP027725.1|AZE92205.1|49553_49829_+|hypothetical-protein
MSEGPVITKKQFIAGAVCPACSEPDKLKMWTEDNVPHRECVACGYTDTLNDQGLSVPKELGTRVNTSALKAPADPKVQAVQFFPNPKLKKD
>CP027725.1|AZE92204.1|47505_49557_+|Oligopeptidase-A
MSANNPLLQPYDLPPFSAIRAEHVQPAIEQILADNRAAIADILQSQGKNPTWAGLVLAMDELNDRLGAAWSPVSHLNAVCNSAELREAYEACLPALSAYSTEMGQNRELFQAFEALANSPEAAGFDVAQKTILEHSLRDFRLSGIDLPPEQQKRYAEVQSKLSELGSTFSNQLLDATQAWTKHVTDQATLAGLTDSAKAQMAAAAQAKGLDGWLITLEFPSYYAVMTYAQDRALREEVYAAYCTRASDQGPNAGQNDNGPVMEQILDLRQELAQLLGYASFAELSLATKMAESSDQVLSFLRDLARRSKPFATQDLQQLKAYAAEQGCADLQSWDSGFYGEKLREQRYSVSQEALRAYFPIDKVLGGLFAIVQRLYGIEIAEQKGFDAWHPDVRLFEIKENGQHVGRFFFDLYARANKRGGAWMDGARDRRRTLDGVLQSPVANLVCNFTPADSGKPALLTHDEVTTLFHEFGHGLHHLLTRVEHAGVSGINGVAWDAVELPSQFMENWCWEPEGLALISGHYETGEPLPQDLLEKMLAAKNFQSGLMMVRQLEFSLFDFELHATHGDGRSAAQVLEGVRDEVSVMRPPAYNRFPNSFAHIFAGGYAAGYYSYKWAEVLSADAFSKFEEDGVLNAQTGRAFREAILARGGSQEPMVLFVDFRGRAPSIDALLRHSGLSEDAAA
>CP027725.1|AZE92203.1|46861_47404_-|Protein-YrdA
MTLRTYQNHTPTLGAGAFVDVSAVVIGDVDIGADSSVWPLTVIRGDMHRIRIGARTSVQDGCVLHITHAGPFNPDGFPLLIGDDVTIAHKVMLHGCTVGSRILIGMGSIVMDGAVVEDDVIIGAGSLVPPGKKLDSGFLYVGSPVKQVRPLTDKERAFFTYSAANYVKLKDLHIAQGFAQ
>CP027725.1|AZE92202.1|46205_46865_-|Phosphoglycolate-phosphatase
MTLHHQTVLFDLDGTLTDPREGITRSIQYALGKLGIDEPDLTRLEHFIGPPLLQAFMQFYGFDEARAWEAVNFYRERFKVTGLYENQVFDGVMPLLEELNSQGRQLYVATSKPWEFAREIARHFDFVKHFKVIYGSELDGTRTNKVELIAHLMREEGLDPASTLMIGDRKHDLIGARSNGLDSVAVGYGFGSFEELNAEAPTWHFETLAQMHQAFLQRI
>CP027725.1|AZE92201.1|45077_46121_+|aminopeptidase
MIRRFLPGLMVMLLSGCSSVSYYGQLASGQWHLLRAREPVAEVVADPARPQSLREHLVQSQKARRFASEQLHLPDNQSYRLYADIGRPYVVWNVFATQEFSLSAQNHCFPIAGCVAYRGYYSQGAARGEAALLRQQGMDVAIGGVEAYSTLGWFDDPIISSMMNWGDERLATLIFHELAHQRFYVKDDTEFNESFASFVEQEGTRQWRAWRGLAPLSDATLQQRDQFTRLILDTRKRLEHLYAQPLAADVMRQAKAAQFERLRSEYRHLRDSQWGGDKRYDAWINQPMNNARLLPFGLYDQWVPAFAALFAQEGRDWVRFYGAVEKLGGLPVEQRKAALRQLEKAAL
>CP027725.1|AZE92200.1|44552_44975_-|Phosphonate-ABC-transporter-phosphate-binding-periplasmic-component
MRQLLYPIAALLLSACASTPIPPVDPQQAWVDFTTPTPGAKLVMAQRLDGKNLEDGRYFQMPPGAHELMVRFDFEVPAGGGLGGLSQMMYRTCFMTLQYDHFQAGQRYVLEGRSLAFTPNIRLYDSARQLLAEERSVNCI
>CP027725.1|AZE92199.1|44312_44552_+|hypothetical-protein
MKRFALAVICGVLATSAVAAPKDCEELRKEIEVNIQAKAIPSYTLEIITAEEAKNHDSAMIVGSCENGTKRIIYQKNND
>CP027725.1|AZE92198.1|43677_44109_+|Peroxiredoxin-OsmC
MSIVKKASAHWEGDLKTGLGSISTETGVLREAPYGFKARFEGGKGTNPEELIGAAHAGCFSMAFSMILGDAGLKADSIDTEAQVTLDQVEGGFAITAVHLVLKAKIPGASQAQFDELSKKAKEGCPVSKVLNATITLDATLLN
>CP027725.1|AZE92197.1|42461_43463_-|Luciferase-like-monooxygenase-YhbW
MKSLSDVKFSTLDLVPVRANGSAAQSLRNSLDLAQHVEKLGYNRFWVAEHHNMDGIASSATSVLLGYLAGGTSTIRVGSGGVMLPNHAPLVIAEQFGTLESLYPGRIDLGLGRAPGSDQMTARALRRERSGSADDFPQDVAELMAYLGPRTPDQRVIAVPGTGTNVPVWLLGSSLFSAQLAGERGLPYAFASHFAPRLMHEAIRVYRNHFKPSPVLDKPYVMLGIPLVAADTDEQADYLATSVYQRILALMRGQSLVQRPPVNTMDGLWLPHEKEAVGSFLGLAMVGSPAKIRAKLEVLIEQTGADELIFTCDLYEHADRIHSYELLAQVMKG
>CP027725.1|AZE92196.1|42089_42314_+|hypothetical-protein
MKKFLLAAGLLSLAGTALAAGKPCEDLKSEIAAKIDAKGASGYSLEVVDKGAAAGGDVVGSCEGGTKEIVYKRG
>CP027725.1|AZE92207.1|50534_51287_+|Gluconate-2-dehydrogenase,-membrane-bound,-gamma-subunit
MSDQDQDNPRRDFLRKSLTLIPVVTVASTGFGGSMLMATPEPAQAAPAKPAPSDKAYEPTYFTAEEWAFINAAVERLIPADAQGPGALEAGAPEYIDRQMNTPYASGALWFMQGPFNADAAPEMGWQSKLVPKEIYRLGIAATDAWSKAFNGKAFAAQDSATRDDMLRRLEAGGSEVSAHFDAVPPKMFFNLLLQNTKEGFFCDPIHGGNKGMVGWTMIGFPGARADFMDWVERNEPYPFPAVSIRGERA
>CP027725.1|AZE92208.1|51283_53074_+|Gluconate-2-dehydrogenase,-membrane-bound,-flavoprotein
MSVAIIMKKVDAVIVGFGWTGAIMAKELTEAGLNVVALERGPMQDTYPDGNYPQVIDELTYSVRKKLFQDISKETVTIRHSVNDVALPNRQLGAFLPGNGVGGAGLHWSGVHFRVDPIELRMRSHYEERYGKNFIPKDMTIQDFGVSYEELEPFFDYAEKVFGTSGQPWTVKGQLVGEGRGGNPYAPDRSNPFPLEAQKNTVSAQLFQKAAADVGYKPYNLPSANTSGPYTNPYGAQMGPCNFCGFCSGYVCYMYSKASPNVNILPALRQVPNFELRPNSHVLKVNLDSTGKKATGVSYVDGQGRECEQPADLVILGAFQFHNVRLMLLSGIGKPYDPITNEGVVGRNFAYQNMGTIKAFFDKDTHTNNFIGAGGNGVAIDDFNADNFDHGPHGFVGGSPMWVNQAGSRPIAGTSNPPGTPAWGSAWKRATADYYTHQVSMDSHGAHQSYRSNYLDLDPVYRDAYGLPLLRMTFDWQENDIKMNRFMMEKMGKVAQAMNPKAIAVLGKKVGEHFNTASYQTTHLNGGAIMGTDPKTSALNRYLQSWDVHNVFVPGASAFPQGLGYNPTGLVAALTYWSARAIREQYLKNPGPLVQA
>CP027725.1|AZE92209.1|53086_54385_+|Gluconate-2-dehydrogenase,-membrane-bound,-cytochrome-c
MKALVIASLALFSSCSVSAAETDLIKQGEYLARAGDCVACHTAKGGKPFAGGLPMETPIGVIYSTNITPDKTGLGDYSFEDFDKAVRHGVAKNGSTLYPAMPYPSYARVSDSDMQALYAYFMKGVEPVAQENKDSDIPWPLSMRWPLAAWRWMFAPSVEEHQVQTTADPVVSRGAYLVEGLGHCGACHTPRALTMQEKALSAADGSAFLSGSAPLEGWIAKSLRGDHKDGLGNWSEEQLVQFLKTGRSDRSAVFGGMSDVVVHSMQYMSQDDLTAIARYLKSLPAVDPKDQPHQYDKQVAQALWKGDDSKPGASVYIDNCAACHRTDGHGYTRVFPALAGNPVLQTADATSLINIVLNGGTLPATHAAPSTFTMPAFAWRLSDQEVADVVSFIRSSWGNQGAPVSAGDVADLRKNDMRTTSGDDLGQVTQKH
>CP027725.1|AZE92210.1|54455_55514_+|Radical-SAM-domain-protein
MTTALPPRGRGTATNLHNRFAPTVSVAEDDGWFQEVPPTQGTEVRIETAKTIITRNNSPDLPFDRSINPYRGCEHGCIYCYARPSHAYWDMSPGLDFETRLIAKSNAADVLEQQLSKPGYVCAPINLGSNTDPYQPIEREYRITRQTLEVLLRYRHPVTIITKGSLILRDLDLLAELARQRLVAVMISLTSLDDELKRILEPRTAAPKARLRAIRVMREAGIPVGVLCSPMIPMINDMELESLLTEAHAAGAQSAAYMMLRLPLEVAPLFEEWLAAHYPQRAAHVMSLVRQVRGGEVYDSRFGVRMRGEGPFADLLAQRFSKAIKRLGLNRREGFNLDCTAFCPPGRQMALL
>CP027725.1|AZE92211.1|55741_56473_+|Carbonic-anhydrase,-beta-class
MSDKDKQPLAASASAPQVAETADAALQHIVDGFLHFHHDVFPQQEELFKKLATAQSPRAMFITCADSRIVPELITQSSPGDLFVTRNVGNVVPPYGQMNGGVSTAIEYAVLALGVQHIIVCGHSDCGAMRAVLNPDSLEKMPTVKAWLRHAEVAKAMVHDNCDCANEGESMKVLTEENVIAQLQHLRTHPSVASRMANGQLFIHGWIYNIETSEIRAYDADQSAFRPLGGEGPIPSATPKARF
>CP027725.1|AZE92212.1|56558_58106_+|Na(+)-dependent-bicarbonate-transporter-BicA
MRAAQLKAVLPRELLASVVVFLVALPLCMGIAIASGMPPAKGLITGIIGGLVVGWLAGSPLQVSGPAAGLAVLVFELVRQHGMLMLGPILLLAGFLQLVAGRLRLGCWFRVTAPAVVYGMLAGIGVLIVLSQIHVMLDGAPKPSGLDNLAGFPAALIEAIPTLGGGLGWQAGLLGVSTMLVMYLWEKFRPQKLRFVPGALLGVGLATVTSLVLALQVKRVEVPENLSDAIDWLRPSDLLNLADPQLLIAAFAVAFIASAETLLSAAAVDRMHSGQRSDFDKELSAQGVGNMLCGLVGALPMTGVIVRSSANVQAGATTRLSAMFHGLWLLGFVLLLSSVLQSIPVASLAGVLVYTGIKLVDVKAFKALGRYGRMPMFTYAATALAIIFTDLLTGVLVGFGLTLVKLAFKASRLKVSLIDLPQDGEMELRLTGAATFLKVPALTQVLSTVPMGTTLHVPLNNLSYIDHSCLELLEEWGRANAAKGSKLVIEARGLKRRLEGRVRTTVGIGSAPSTT
>CP027725.1|AZE92213.1|58242_58878_-|hypothetical-protein
MNTAALREQISRAHQHEETTGQLARQLEKQLPHLHSAISLADGDRNIVMTRFVTAYIDLVPELLDAANDVAREAGIESQIKPVLKIAEHFFLQPPAILAGHEGLDGLLDEAYLAHRLVEEVNDLYIKHFGQPLIPADTTVANLIAHQLIGEAFANQLDEAVHLAVDEMLNEESFALESVEAYRETLKSPNTEAAWKRWPCLSRQLGVELAL
>CP027725.1|AZE92214.1|59329_60376_+|Cytochrome-c-oxidase-polypeptide-II
MAPGATEVSHAVFDLHMTIFWICVVIGIVVFGAMFWSMILHRRSTGQVAAKFHESTTVEILWTVVPLLILVAMAIPATKTLINIYDSSESDIDIQVTGYQWKWHYKYLGQDVEFFSNLATPAEQIHNQATKGEHYLLEVDQPLVLPVGAKVRFLVTAADVIHSWWVPAFAVKRDAIPGFVNEAWTRVEKPGIYRGQCAELCGKDHGFMPIVVEVKSKADYDTWLGERKQEAAKLKELTSKEWTLEELVARGDKVYHTTCVACHQAEGQGLPPMFPALKGSKIATGPAADHLNIVYHGKPGTAMAAFGKQLSEVDIAAVVTYERNAWGNNKGDMVTPKDVLTLKQAQSK
>CP027725.1|AZE92215.1|60434_62021_+|Cytochrome-c-oxidase-polypeptide-I
MSTAIDDHGHADHAHGPAKGLMRWVLTTNHKDIGTMYLWFAFTMFLLGGSFAMVIRAELFQPGLQIVEPAFFNQMTTMHGLIMVFGAVMPAFVGLANWMIPLMIGAPDMALPRMNNFSFWLLPAAFLLLVSTLFSPGGGPNFGWTFYAPLSTTYAPESVTFFIFAIHLMGISSIMGAINVVATILNLRAPGMTLMKMPLFVWTWLITAFLLIAVMPVLAGCVTMMLMDIHFGTSFFSASGGGDPVLFQHVFWFFGHPEVYIMILPAFGAVSSIIPTFSRKPLFGYTSMVYATASIAFLSFIVWAHHMFVVGIPLVGELFFMYATLLIAVPTGVKVFNWVSTMWQGSLTFETPMLFAVAFVILFTIGGFSGLMLAIAPADFQYHDTYFVVAHFHYVLVPGAIFGIFASAYYWLPKWTGHMYDETLGKLHFWLSFVGMNMAFFPMHFVGLAGMPRRVPDYNLQFADFNMVSSIGAFMFGATQIFFLFIVIKCIRGGPPAPAKPWDGAEGLEWSVPSPAPYHTFTTPPEVK
>CP027725.1|AZE92216.1|62017_62167_+|hypothetical-protein
MSSPAQFSCGRELAPDSYLTANESVDRYTAIGGKPPPTLIVSALGGCHG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: CP027725_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_3

2286195-2286288

Orphan

Consensus_repeat	Method
TCCAAATGTGGAAGGGGGCTTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_3

>merge|CP027725|3|2286195-2286288|CRISPRCasFinder
TCCAAATGTGGAAGGGGGCTTGCTCCCGTGACGGCCGGACAGCCAACGCGTATCTACCTGATGCTGCGAGGTCCAAATGTGGGAGGGGGCTTGC

>CP027725|3|3|2286195-2286288|CRISPRCasFinder
TCCAAATGTGGAAGGGGGCTTGC	TCCCGTGACGGCCGGACAGCCAACGCGTATCTACCTGATGCTGCGAGG
TCCAAATGTGGGAGGGGGCTTGC

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE94205.1\|2284688_2286188_+\|Two-component-transcriptional-response-regulator,-LuxR-family	unknown	unknown	gnl\|CDD\|143635
CP027725.1\|AZE94212.1\|2293318_2294176_+\|Oxidoreductase,-short-chain-dehydrogenase/reductase-family	unknown	unknown	gnl\|CDD\|187613
CP027725.1\|AZE94203.1\|2283422_2283773_-\|Uncharacterized-protein-YmdF	unknown	unknown	gnl\|CDD\|226252
CP027725.1\|AZE94215.1\|2294940_2295222_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94204.1\|2284063_2284240_-\|Uncharacterized-protein-YmdF	unknown	unknown	gnl\|CDD\|226252
CP027725.1\|AZE94198.1\|2279543_2280713_-\|Zn-dependent-dehydrogenase	unknown	unknown	gnl\|CDD\|176243
CP027725.1\|AZE94213.1\|2294356_2294596_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94208.1\|2287652_2287874_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379161
CP027725.1\|AZE94202.1\|2282817_2283369_-\|Protease-subunit-of-ATP-dependent-Clp	unknown	unknown	gnl\|CDD\|223811
CP027725.1\|AZE94207.1\|2287141_2287441_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94210.1\|2288412_2288856_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225205
CP027725.1\|AZE94206.1\|2286923_2287142_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94196.1\|2277493_2278204_-\|Phosphoglycerate-mutase-family-protein	unknown	unknown	gnl\|CDD\|366010
CP027725.1\|AZE94199.1\|2280712_2281546_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176859
CP027725.1\|AZE94201.1\|2282107_2282377_+\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94200.1\|2281937_2282063_+\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94214.1\|2294592_2294850_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94197.1\|2278396_2279422_+\|putative-protease-sohB	unknown	unknown	gnl\|CDD\|236978
CP027725.1\|AZE94211.1\|2288852_2293010_-\|Chemotaxis-protein-methyltransferase-CheR	unknown	unknown	gnl\|CDD\|214534
CP027725.1\|AZE94209.1\|2287887_2288403_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE94205.1\|2284688_2286188_+\|Two-component-transcriptional-response-regulator,-LuxR-family	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.7113e-53
CP027725.1\|AZE94203.1\|2283422_2283773_-\|Uncharacterized-protein-YmdF	gnl\|CDD\|226252	COG3729, GsiB, General stress protein [General function prediction only].	3.89798e-06
CP027725.1\|AZE94204.1\|2284063_2284240_-\|Uncharacterized-protein-YmdF	gnl\|CDD\|226252	COG3729, GsiB, General stress protein [General function prediction only].	0.000257897
CP027725.1\|AZE94198.1\|2279543_2280713_-\|Zn-dependent-dehydrogenase	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
CP027725.1\|AZE94202.1\|2282817_2283369_-\|Protease-subunit-of-ATP-dependent-Clp	gnl\|CDD\|223811	COG0740, ClpP, Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	3.79588e-30
CP027725.1\|AZE94210.1\|2288412_2288856_+\|hypothetical-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	3.19006e-39
CP027725.1\|AZE94212.1\|2293318_2294176_+\|Oxidoreductase,-short-chain-dehydrogenase/reductase-family	gnl\|CDD\|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.41077e-150
CP027725.1\|AZE94196.1\|2277493_2278204_-\|Phosphoglycerate-mutase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.77026e-28
CP027725.1\|AZE94199.1\|2280712_2281546_-\|hypothetical-protein	gnl\|CDD\|176859	cd07817, SRPBCC_8, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.72409e-16
CP027725.1\|AZE94208.1\|2287652_2287874_+\|hypothetical-protein	gnl\|CDD\|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	0.000632882
CP027725.1\|AZE94197.1\|2278396_2279422_+\|putative-protease-sohB	gnl\|CDD\|236978	PRK11778, PRK11778, putative inner membrane peptidase; Provisional.	0
CP027725.1\|AZE94211.1\|2288852_2293010_-\|Chemotaxis-protein-methyltransferase-CheR	gnl\|CDD\|214534	smart00138, MeTrc, Methyltransferase, chemotaxis proteins. Methylates methyl-accepting chemotaxis proteins to form gamma-glutamyl methyl ester residues.	1.2451e-103

>CP027725.1|AZE94205.1|2284688_2286188_+|Two-component-transcriptional-response-regulator,-LuxR-family
MKRDTRLVMLLLLVIGCSLTSLTIWKVLSSRERALAEVDVHGLNLTQALTTYTEGIVRQSALILLGLVERLETDGSGPAQIQRISTLIRRQQPLMPQLSGITIYDRQGGWLMSSNRVIPAGANSSARAYFIHHRDDPSREPFIGPPIQSHTNREWVVTISRRFDDAAGNFAGVVAVTLGVENFLRVFGKLDVGQDGAIGLSYTDGTLLVRYPFREQDMGRNFSKSPIYSQHLVDRSVGTASYTSSLDGVERLYAFRKSESLPLITTVALGKHESLAAWRIEAALSAVVVAGLLGLTGLIGWFLILDIRRRTLVEEALRIAQQQLLDSNRQLELLAMKDALTGLANRRCFDDTLALEARRAQRDGTSLALLMIDIDYFKRYNDALGHVAGDACLQRVSQLLETCVRRPSDLVARYGGEEIAIIMPATDREGAAVVAQLIIDRLLRENIEHPGSPFGCVSVSIGVAAAAGVELEPVLGLIEAADKALYGAKSAGRNGFALN
>CP027725.1|AZE94204.1|2284063_2284240_-|Uncharacterized-protein-YmdF
MTTSNKNPGNFANDREKASEAGKKGGQASGGNFANDREKASEAGRKGGQNSHGGGRKS
>CP027725.1|AZE94203.1|2283422_2283773_-|Uncharacterized-protein-YmdF
MSTQDKQGQMSVNEAGKKGGEATSASHDKEFYQEIGSKGGQNSGGNFKNDPERAAEAGSKGGQNSGGNFKNDPERASEAGRKGGQNSGGNFANDREKASEAGRKGGENSHGGGRNS
>CP027725.1|AZE94202.1|2282817_2283369_-|Protease-subunit-of-ATP-dependent-Clp
MPLHIINFTGPVTASTCSQLIEKASLAVQQDASGLVLNIATMGGECSYGFTMYNFLLSLPIPVHTHNLGTVESMGNIIFLAGERRTACIHSKFLFHPFHWHVQGAVDHSRMSEYAMSLDYDLQLYARIVAERTAGASETLETEKYLIAAPRILNPHQAMAAGLIHAIELPVIKAEFVSSFIHS
>CP027725.1|AZE94201.1|2282107_2282377_+|hypothetical-protein
MKNSLYIIEYDYHKEPKSFIIRAEVMNNAEAWHWACCDAGIGVIPRSRNERIKRISKPLAERYGLENVRWRPSGSVPFVAQPYVPPPPE
>CP027725.1|AZE94200.1|2281937_2282063_+|hypothetical-protein
MNRLTIENQKKGGRFIFFRGLPTNGRLLLKMQNLSFGLEKF
>CP027725.1|AZE94199.1|2280712_2281546_-|hypothetical-protein
MPEQPLIANHTPQDTHRRGTLTKAERALSLTAGAALLLQGWRKGGLGGALHSAAGAYAVFRGYAGHCSLKRALTPTPFEQQFSREHHWPISEAITRSITIARPLEEVSAFIARPEQIGPLLRWVDSVEQLAPDTTLWALRAPAGKRVQCTLIQTQSQEPSVLHWKTPGDARWAHDITVSLTPAPAGRGTQVKAVVVCKPAMGKLGYGLARAISLFSDKALLNALQAVKQQLETGEVSNNRLRPEQDDDFFYVHAAAEDVATDHPTVKTGVALEGGPH
>CP027725.1|AZE94198.1|2279543_2280713_-|Zn-dependent-dehydrogenase
MRALTWQAPNLLQVDNVPDPTILNPRDAIIRVTLSSVCGSDLHLLGGYVPAMKPGDIIGHEFMGEVVEVGKGITDLRQGDKVVTISIIGCGNCEPCQRSDFSCCDNSNPNPSATDLLYGQPCCGILGYSHAFGGYPGSHATYVRVPFADVNLFKVPEGVSDEQALFVSDAAPTGYFAADNAGIQPGDTVAVWGCGGVGQMAICSAYLLGAERVIAIDRYPDRLRLAEERGKAIPINYEKTNVHEALLELTGGRGPDRCIDCVGMEAHGTEIDYAYDKAKQLLRLHTERGTVLRQAIRACRKGGTVSVAGVYGGLLDKFPMGAIVNKALTLKSGQQPGQRYATTLFEHIQKGELDPAYLLTHPMSLEDGAQGYKLFKEKSDQCLRAVFKP
>CP027725.1|AZE94197.1|2278396_2279422_+|putative-protease-sohB
MDFLAEYASFLAKTVTLVVAILVVLISFAALRSKGRRKAAGQLQVSKLNDFYKGLRERLESSLLDKDQLKALRKAESKADKKQGKHKPEAKPRVFVLDFDGDIKASATESLRHEITALLSLATPKDEVVLRLESGGGMVHSYGLASSQLARIRQAGVPLTVCIDKVAASGGYMMACIGEKIISAPFAILGSIGVVAQLPNVNRLLKKHDIDFEVLTAGEYKRTLTVFGENTEKGREKFQEDLDITHQLFKNFVSRYRPQLAIDEVATGEVWLGVAALDKQLVDELQTSDEYLATKAKTAEVFHLHYAERKSLQERVGLAASGSVDRVLLTWWSRLTQQRFW
>CP027725.1|AZE94196.1|2277493_2278204_-|Phosphoglycerate-mutase-family-protein
MGSIYLIRHGQASFGADDYDVLSPVGVEQAQVLGRHLADLGLTFDRCLSGDLRRQQHTATAAFDQYSALGLPVPPLEIDSAFNEFDGEAIIRGLLPDLLGAEPNAMHVLRNGTQNRSEFQRIFALIIERWLAGTYDPPGLESWQGFVERVEAGLQRILEAADNSHRIAVFTSGGTITALLHLITRMPVAQAFELNWQIVNTSLNQLKFRGREVALASFNSHAHLQLLKAPQLITFR
>CP027725.1|AZE94206.1|2286923_2287142_-|hypothetical-protein
MNTSKQAWELAMVLVANGKIPFDPANPSGSVKILSRHLEALETALHEEAMANTPVERLRKLGNRRSALACAD
>CP027725.1|AZE94207.1|2287141_2287441_-|hypothetical-protein
MHHTDTYAKRMACRQLAMEQNQKLFDEANALSRSAFDLLECADFDSEKFDHYLRLRAKAEALFREAIEHLGVLNTHFPTPASSVANEGATVVIREQEVA
>CP027725.1|AZE94208.1|2287652_2287874_+|hypothetical-protein
METTYFWIGLMIILLLLDLWVLNSVWRSENSSGSKAGWTAVVVLLPFLGAVIWAVSGPRGVTKGPSSPEHSKG
>CP027725.1|AZE94209.1|2287887_2288403_+|hypothetical-protein
MSESGPDDLHSRDYPVREDMALQRKVWRFERLGWYGLVVLIGLTLAGLFSKGPLSTSEVRSANGHVRVEYQRFLRNGSSDALVIHLQGPARTPLEVAISGELLRGFNVEMLQPQPLKASTAGEGVKLWTLSDNQGRATLYLTLRSDGVGSFDTQVSLGNGATVALSQFIYP
>CP027725.1|AZE94210.1|2288412_2288856_+|hypothetical-protein
MDSVLRAAAIYLVLLVLFKIAGRRSLAELTTFDLVLLMVIGEATQQALLGDDFSLTNAVLVIVTLIAIDIGFSLVKQRSLWFSRLLDGGPTVVVEQGRVLHERLKRARLDEDDILEAARSSQGILEIRQIRFAILERNGKISVIPYD
>CP027725.1|AZE94211.1|2288852_2293010_-|Chemotaxis-protein-methyltransferase-CheR
MKSAPPRSPNVPQRKDLIPSTLNFPVVGIGASAGGLQAVKAFFEHMPQDCGMAFVVILHLSPDHQSVADKIIQESTRMPVQQVNEATPIEKNRVYVISPAQHLLMNDGYLAVAPSAREGGSHIAIDLFFRDLADTHKEHAFCLILSGTGSDGAVGLSRIKEQGGVTLVQSPEDAEFDGMPLAAIETQMADLVLPVVEMPQKLLELWRNAQSIILPTANDPEIKTTPPATERDAAVAEQLLLDILIQLRLSTGHDFKHYKRATVLRRIERRLQVTAQPDLASYYEYLQTHPEETKALLGDMLIGVTNFFRDREAFEALERDVIPNLVKSLEDSVPKREEVRIWSAGCSTGEEAYSLAMLVAEQLALDASDAKMQVFATDIDERAINHGRNGAYPEAIITDVPPPRLRQYFAKEKNQHYRVRKEIREKVLFAKHSLLSDPPFSQIDLIVCRNLLIYLDREVQRDILQMFHFALRPGGYLFLGSSESADGCLDLFVPVDKRNRIFRVRAGSAAMRRAPTMPRGGYLRPNASAAAAQIKIPNKISFADIHLRALEKAAPPSVIVDMQADILHMSEGAGRFLRHVAGEMTRNLLALVHPDLRLDIRTTLFQVQQSSLAVTSRKVRIERDHAQYLVDITALPYRDEATESDYVLVIFQETEVDPQHAEETAIGHAENQMMSNLERELQRTKLHLQDTIEQAEVSSEELKASNEEMQAVNEELRSATEELETSKEELQSINEELLTVNFELKTKVEETDKVNDYLTNLIASTDIATVFVDRNMRIRWFTPRATDLFNMLPVDTGRSLMDITHRLTYPEMIDDASTVFESLSMIEREISSKDDRWYIARLLPYRSSEDHIDGTVLTFIDITKRRQAEEELRLGEERMRLVADSTHDFAIIILDDHGAITDWNTGAELIFGYTKQEVLGAYYDLIFSPEDRTAGIPENELRAAREHGRGEDERWHVRKDGSRFYCSGEVTLLTGNSLQGYVKIARDLTGHKRTQDEQSQRLMETQTNSHLKDEFFAVMSHELKHPLNLIQLNAELLRRLPATKATGPAIKAVNTICEAVSSQARIIDDLLDVARVRTGKLKLKKQRVDLIRTLEDIHAVVLADGHRCQVTLNKPTTPAALFVDADPTRLEQVVWNLVNNALKFTPEQGRVQLVVSRTEGFARLDVIDSGAGLAEDSLEKIFDLFGQAENQHQTHQREGLGIGLSLVRQLVEAHGGTVSVYSKGLGFGCTFSVSLPLSQQQDLPSSSDAAQSSDERLSGVKVLLVDDSEDVLEVLNMLLEMEGAEVSAFDDPLNALEVAADKPYDLIISDIGMPKMNGHELMRKLRQMSHLQQVPAIALTGYGASSDQKKTADSGFSTHVSKPVTHDALISLIETLCRSRRSVGG
>CP027725.1|AZE94212.1|2293318_2294176_+|Oxidoreductase,-short-chain-dehydrogenase/reductase-family
MTHYPKPPFKPQQQPVPGDQRKMEPMPDCGEQSYKGSGRMANKIALITGADSGIGRAVAIAFAREGADVAVSYLDEHEDAKETARWVEAAGRQCLLLPGDLGEAAQCSAIVNETVKQFGRIDVLVNNAAFQMTYKSLEDIPDEDWVKTFNVNITAMFRICKAALPHMAEGSSIINTTSVNSDMPNPSLLPYAATKGAIANFTAGLAQMLGERGIRVNSVAPGPIWTPLIVSTMTDDMVKEFGGNTPLGRPGQPVEVAPIYVLLASDEGSYISGERYGVTGGKPIL
>CP027725.1|AZE94213.1|2294356_2294596_-|hypothetical-protein
MNSQVLGFTKRQAVDDEIAQNTQMFFEADRLDALAYKIIESYSGDAATWARFTEAKKVADAQRTAAYREWMRIHRARKK
>CP027725.1|AZE94214.1|2294592_2294850_-|hypothetical-protein
MNKSELFTINYQLHGKPRSFIVRAARMNNAEAWHWASCDAGVAVIPRFGQNNLKRVSKPMAEKYGITDVRWCGAAAIQWAEGVTS
>CP027725.1|AZE94215.1|2294940_2295222_-|hypothetical-protein
MSYDHQGTVSVITASRHLGTEDDEVLNENVDIKMTSSGKPTIVRVDFPTPLQWPGHPNFVTVNLPDGTSVGGVVVALERPADGPGWVTFTVDD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: CP027725_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_4

2378969-2379063

Orphan

Consensus_repeat	Method
AATGTGGGAGGGGGCTTGCTCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_4

>merge|CP027725|4|2378969-2379063|CRISPRCasFinder
AATGTGGGAGGGGGCTTGCTCCCGTGACGGCCGGACAGTCAACGCGTATTTACCTGACGTTCCGAGGTAAAAATGTGGGAGGGGGCTTGCCCCCG

>CP027725|4|4|2378969-2379063|CRISPRCasFinder
AATGTGGGAGGGGGCTTGCTCCCG	TGACGGCCGGACAGTCAACGCGTATTTACCTGACGTTCCGAGGTAAA
AATGTGGGAGGGGGCTTGCCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE94287.1\|2375042_2375822_-\|Hydroxypyruvate-isomerase	unknown	unknown	gnl\|CDD\|226149
CP027725.1\|AZE94288.1\|2375818_2376823_-\|Myo-inositol-2-dehydrogenase	unknown	unknown	gnl\|CDD\|275173
CP027725.1\|AZE94286.1\|2374097_2375024_-\|Sugar-ABC-transporter,-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380524
CP027725.1\|AZE94283.1\|2371484_2372711_+\|putative-MFS-type-transporter	unknown	unknown	gnl\|CDD\|182309
CP027725.1\|AZE94291.1\|2380813_2381905_+\|MocD	unknown	unknown	gnl\|CDD\|239588
CP027725.1\|AZE94299.1\|2388368_2389496_+\|N-ethylmaleimide-reductase	unknown	unknown	gnl\|CDD\|239243
CP027725.1\|AZE94298.1\|2387596_2388274_+\|ThiJ/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153235
CP027725.1\|AZE94292.1\|2381936_2382260_+\|MocE	unknown	unknown	gnl\|CDD\|131430
CP027725.1\|AZE94295.1\|2385207_2385846_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227915
CP027725.1\|AZE94293.1\|2382259_2383459_+\|Ferredoxin-reductase	unknown	unknown	gnl\|CDD\|170080
CP027725.1\|AZE94290.1\|2379602_2380652_-\|Transcriptional-regulator,-LacI-family	unknown	unknown	gnl\|CDD\|380530
CP027725.1\|AZE94284.1\|2372755_2373583_+\|Glutathione-S-transferase	unknown	unknown	gnl\|CDD\|183298
CP027725.1\|AZE94279.1\|2367153_2368122_+\|L-arabinose-transport-system-permease-protein	unknown	unknown	gnl\|CDD\|183076
CP027725.1\|AZE94294.1\|2383460_2384348_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366542
CP027725.1\|AZE94296.1\|2385834_2386797_-\|Transcriptional-regulator,-AraC-family	unknown	unknown	gnl\|CDD\|227311
CP027725.1\|AZE94285.1\|2373842_2373977_+\|Threonine-synthase	unknown	unknown	unknown
CP027725.1\|AZE94281.1\|2369523_2370291_+\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|212491
CP027725.1\|AZE94280.1\|2368236_2369385_-\|Aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185696
CP027725.1\|AZE94282.1\|2370433_2371423_-\|Transcriptional-regulator,-AraC-family	unknown	unknown	gnl\|CDD\|225117
CP027725.1\|AZE94297.1\|2386970_2387600_+\|Transcriptional-regulator,-AcrR-family	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE94287.1\|2375042_2375822_-\|Hydroxypyruvate-isomerase	gnl\|CDD\|226149	COG3622, Hfi, Hydroxypyruvate isomerase [Carbohydrate transport and metabolism].	8.94184e-84
CP027725.1\|AZE94288.1\|2375818_2376823_-\|Myo-inositol-2-dehydrogenase	gnl\|CDD\|275173	TIGR04380, hypothetical_protein_HOLDEFILI_04020, inositol 2-dehydrogenase. All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars].	6.56187e-117
CP027725.1\|AZE94286.1\|2374097_2375024_-\|Sugar-ABC-transporter,-substrate-binding-protein	gnl\|CDD\|380524	cd06301, PBP1_rhizopine_binding-like, periplasmic binding proteins specific to rhizopines. Periplasmic binding proteins specific to rhizopines, which are simple sugar-like compounds produced in the nodules induced by the symbiotic root nodule bacteria, such as Rhizobium and Sinorhizobium. Rhizopine-binding-like proteins from other bacteria are also included. Two inositol based rhizopine compounds are known to date: L-3-O-methly-scyllo-inosamine (3-O-MSI) and scyllo-inosamine. Bacterial strains that can metabolize rhizopine have a greater competitive advantage in nodulation and rhizopine synthesis is regulated by NifA/NtrA regulatory transcription activators which are maximally expressed at the onset of nitrogen fixation in bacteroids. The members of this group belong to the pentose/hexose sugar-binding protein family of the type 1 periplasmic binding protein superfamily.	1.00627e-117
CP027725.1\|AZE94283.1\|2371484_2372711_+\|putative-MFS-type-transporter	gnl\|CDD\|182309	PRK10213, nepI, purine ribonucleoside efflux pump NepI.	2.85231e-91
CP027725.1\|AZE94291.1\|2380813_2381905_+\|MocD	gnl\|CDD\|239588	cd03511, Rhizopine-oxygenase-like, This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase) under the regulation of MocR, act in concert to form a ferredoxin oxygenase system that demethylates 3-O-MSI to form scyllo-inosamine. This domain family appears to be structurally related to the membrane fatty acid desaturases and the alkane hydroxylases. They all share in common extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain eight histidine residues: HXXXH, HXXHH, and HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within homologs, stearoyl CoA desaturase and alkane hydroxylase.	1.97152e-140
CP027725.1\|AZE94299.1\|2388368_2389496_+\|N-ethylmaleimide-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	7.0109e-179
CP027725.1\|AZE94298.1\|2387596_2388274_+\|ThiJ/PfpI-family-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	2.11965e-103
CP027725.1\|AZE94292.1\|2381936_2382260_+\|MocE	gnl\|CDD\|131430	TIGR02377, putative_Rieske-like_ferredoxin_MocE, Rieske [2Fe-2S] domain protein, MocE subfamily. This model describes a subfamily of the Rieske-like [2Fe-2S] family of ferredoxins that includes MocE, part of the rhizopine (3-O-methyl-scyllo-inosamine) catabolic cluster in Rhizobium. Members of this family are related to, yet distinct from, the small subunit of nitrite reductase [NAD(P)H].	1.01423e-51
CP027725.1\|AZE94295.1\|2385207_2385846_+\|hypothetical-protein	gnl\|CDD\|227915	COG5628, COG5628, Predicted acetyltransferase [General function prediction only].	1.07875e-14
CP027725.1\|AZE94293.1\|2382259_2383459_+\|Ferredoxin-reductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.07902e-80
CP027725.1\|AZE94290.1\|2379602_2380652_-\|Transcriptional-regulator,-LacI-family	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	1.48911e-78
CP027725.1\|AZE94284.1\|2372755_2373583_+\|Glutathione-S-transferase	gnl\|CDD\|183298	PRK11752, PRK11752, putative S-transferase; Provisional.	0
CP027725.1\|AZE94279.1\|2367153_2368122_+\|L-arabinose-transport-system-permease-protein	gnl\|CDD\|183076	PRK11285, araH, L-arabinose transporter permease protein; Provisional.	5.89694e-172
CP027725.1\|AZE94294.1\|2383460_2384348_+\|hypothetical-protein	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	7.4846e-06
CP027725.1\|AZE94296.1\|2385834_2386797_-\|Transcriptional-regulator,-AraC-family	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	1.53704e-92
CP027725.1\|AZE94281.1\|2369523_2370291_+\|3-oxoacyl-ACP-reductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.43796e-65
CP027725.1\|AZE94280.1\|2368236_2369385_-\|Aldose-1-epimerase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	0
CP027725.1\|AZE94282.1\|2370433_2371423_-\|Transcriptional-regulator,-AraC-family	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.29834e-26
CP027725.1\|AZE94297.1\|2386970_2387600_+\|Transcriptional-regulator,-AcrR-family	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.70924e-13

>CP027725.1|AZE94288.1|2375818_2376823_-|Myo-inositol-2-dehydrogenase
MNTKHIRLGLIGAGRMGSFHGLTAARHIPGACLAAIADPTPGQAARLAQELGVDKVYTDPQQLLDDPDIDAILIAAPARSHAELVISAARAGKGIFCEKPMAITLEEADRAIAAAADARVTLQVGFNRRFAKSFRSAHLDVVAGRIGTPQLLRSLTRDPALNNPGASPQWVIFLETLIHDFDTLRYLNPGAEAVQVHVMADALIAPAYKSQGLLDTAVVTIRFDNGAIATAEASFQAVYGYDVRGEVFGSAGMLTMGGVQASDLVRYQAQGIQADTQRLDTELLRDAYIAELNHFVDCLRSGAKPLASGEDARAALAIARACIDSYEQGTAVSL
>CP027725.1|AZE94287.1|2375042_2375822_-|Hydroxypyruvate-isomerase
MIPFKLAVSAEMVFLDLPFVERVKRIHALGFSAEIWSWTDKDINALAATGADFTSMTGYISGTLTDPDGVRHLLDSARQSLSVAARLNCPSLNLHGTGLGDGGLPVQPVSRTIGRMWLGACKTLEKIARLGEDAGRVFLLENLNTEVDHPGTPFARADDTLALIEAVGSAHLKMNLDLYHAQIGEGNLIELIQRAGPAIGEIQVADVPGRQEPGTGEIHYPAIARALHAMGYSGVVGLEGWASGDSNMALERFRQAFTL
>CP027725.1|AZE94286.1|2374097_2375024_-|Sugar-ABC-transporter,-substrate-binding-protein
MHRYSLIVATLLLLFSQSSFAAYRIGVSIARVDDNFMTYVRTGLEAAATQQDVQIQFEDAQGDVVRQLNQVEGFLNQNVDAVIVLPVDTAATANITRAAVASKTPLVYVNRHPDERTLPKGVVTVASNDIEAGQLQMRYLAQKLGGKGNVAIIMGDLAQNATRDRTEGARQVLKDFPGIRIVEQQSAEWQRSKAMDLTSNWLLAGTQFDAIVANNDEMAIGAAMALHQAGKAKGEVAIVGIDGLPDGLAAIRRGELSASVFQDPKAQATQAVQAAVRMIKGETIEPEVWVPFELIKPEQVAVFEQRYK
>CP027725.1|AZE94285.1|2373842_2373977_+|Threonine-synthase
MGSVCPNAGLNPWAAAMGHPWPSAANPASCRVTHGFKPAFGQRG
>CP027725.1|AZE94284.1|2372755_2373583_+|Glutathione-S-transferase
MADYVPPKVWTWDAESGGTFASINRPIAGATHERALPVGKHPLQLYSLATPNGQKVTILLEELLALGHTGAEYDAWLIKIGDGDQFGSGFVGVNPNSKIPALMDHSGAAPIRVFESGAILQYLAEKFAAFFPTEPAARAECLSWLFWQMGSAPYLGGGFGHFYAYAPSKMEYPINRFAMEAKRQLDVLDKRLAVSEYIAGDEYTIADIAIWPWYGGLVKGRLYGAAEFLSVQEYKHVLRWADAIDARPAVQRGRRVNRVSGDDQLAERHDARDLD
>CP027725.1|AZE94283.1|2371484_2372711_+|putative-MFS-type-transporter
MTDCAARAPAGMVAEPAWLAVFSLAMGVFGLLTAEYLPASLLTPMALDLGVTEALAGQAVTVTAVVALFAGLLVPGLTRGIDRRIVLLGFSTLMIASNLLVALSSSLTVLLLMRILLGIALGGFWSMAAAVAMRLVPAASLPRALSIIFSGIALGTVVAVPLGSYLGGLYGWRSAFIAAAAVGLVTLAFQSFTLPRLAPNGTARLRTVLHVLQRPGIAMGMFGCVLVHTAHFALFTYIRPFLESTTGVGTEGLALMLLGFGVANFAGTLFAGWLLVRHPRATLVLMPVLVGIAALALVWLPASLPTQALLLALWGMAFGGVPVAWSNWVARAVPDQAESAGGMVVASVQSAIAAGAAGGGLMFSVSGIGGVFVGAGVLMLLAALLIALRVQVPGPEGDRSVTRHQSLV
>CP027725.1|AZE94282.1|2370433_2371423_-|Transcriptional-regulator,-AraC-family
MMQNLESLTETPNMTAMDAFTASSDLINELLRGMRLRGVQYRRIQAGPTFGIGFDAKPGHAYFHFLAAGNATLRAEDGSLFALSAGNAVFVSHGGAHALLSSADAAVQDISQFDSAPLGDTVCAVDASPDTVPDRLLFSACMEFELGSLQGLGNLMPALMLIDTAGQRYPGLMPILAVMEREVSTARVGYAGILARLADVVAAMIVRGWVECACGNASGLAAALRDPRLARALLALHQQPGHDWSVAELAAQCHTSRSVFADRFQAVLGVPPLRYATQLRMRLASQWLTLERMPIETVAQRLGYTSQAAFSRAFKRITGQPPGAARRSI
>CP027725.1|AZE94281.1|2369523_2370291_+|3-oxoacyl-ACP-reductase
MSTEHALYPDLKGKTVLISGGASGIGEFMVRAFAAQGAKVAFVDRAQSQGERLAALLNSKGHTVEFECCDITDEIGYRAAIGRFEHSLGPITVLVNNAANDVRHTLEEIDSEMFDRLIAVNLKHAFFAAKAVVPMMKHAGGGSIINLGSVGWMMASAGYPVYAASKAAAHGMTRGLARELGPHRIRVNTLVPGWVMTEKQLAMWVDDAARELIARSQCLPGSVMPEHIANMALFLASDASAMCSAQNFIVDGGWV
>CP027725.1|AZE94280.1|2368236_2369385_-|Aldose-1-epimerase
MKHPRYLLSGLALSMLIASGGAQAAGLSSEHKPFGKTNDGTPVEQYVLRNSHGMQATVITYGGVLQSLKVPDKHGKVDDVVLGFDDVQGYQAGTAFFGATIGRFGNRLAGGAFELDGKRYQVPLNDGPNSLHGGAQGFDKQVWKAESVKDKDSVGVKLSYLSKDGEMGFPGNLKTEVTYRLNDKNELHIDYTATTDKPTVLNLTNHSYFNLAGAGNGDILKQVATLHASHYTPVNATLIPTGELAPVKGTPMDFLKPTAIGQHIKDDHPQLKFAEPKQGGFDFNWALDTKGDVKQLAAEVHDPESGRRLQLYTSEPGVQFYTSNFLDGSMKGKGGKAYQHWSGFTLETQHFPDAPNQPGFASTRLNPGQTYTQNTVFKFTAN
>CP027725.1|AZE94279.1|2367153_2368122_+|L-arabinose-transport-system-permease-protein
MTIQDNALPSARKPLDLRALLDNWAMLLAAVGIFVLCALLIDNFLSPLNMRGLGLAISTVGIAACTMLFCLASGHFDLSVGSVIACAGVVAAIVMRDTDSVMLGIGAALLMGLMVGLINGIVIAKLRVNALITTLATMQIVRGLAYIFADGKAVGVSQDQFFVFGNGQLFGVPVPILITIVCFLFFGWLLNYTTYGRNTMAIGGNPEAALLAGVNVDRTKILIFAVHGLIGALAGVILASRMTSGQPMIGQGFELTVISACVLGGVSLSGGIGMIRHVIAGVLILAIIENAMNLKNIDTFYQYVIRGSILLLAVVIDRMKQR
>CP027725.1|AZE94290.1|2379602_2380652_-|Transcriptional-regulator,-LacI-family
MTNHKRPTIATVAAQAGLSVATVDRVLNARAPVNPQTAEQVFQAAEAVGYFAARLIGQRIRERRPTYRFGILLLGTAQAFYANLAQSIGDAAQHHATANLSCQFDYINDRTPSAIVAQIEQLAVQCDALAVVSFAHPLINACLAQIREAGVPVVALLSDIHEQALEPYVGQDNHVVGRTMGWLLARTCGARKGSVGILLGGHRFLGHQARVEGLHRYLAEHAPGLKPLEPLINLDNCDITEEATLDLLSRHTDLRGLCVVGGGGDGVISALAQLPKRPALCCILQESTELSRQALSQGLIDVVMDSQPRQTAVALVELLVQLQSAEGFDAMRHRVHIAPHIVTSENMGN
>CP027725.1|AZE94291.1|2380813_2381905_+|MocD
MPEHTAHRARRDYSLTGPEAARAAEKGLVSACWYQSPVPRKRMKELMQRRDGPALVDTAIWFAALFVSGFGGYWFWGSWACVPFFLAYGVLYGTASNPRWHETGHGTAFKTRWMNDALYQVACFMCLFEPHVWRWSHARHHTDTIVVGRDPEIVEPRPPSFLMMFLSLFNLPLAWKTFSGVARHAIGRMSAQERDFIPESEWTKVFRAARIWVVLYGVIIGSASYLHSWLPLMLVGLPSIYGAWLGYLFGLTQHVGLAEDVLDHRSNCRTIYMNRVLRFIYMNMNYHLEHHMYPMVPYHALAQLHEEIRRDCPPPYANLWAAYKEILPTVWKQRSDPTYFVQRPIRRQPESAPASLHAEISAG
>CP027725.1|AZE94292.1|2381936_2382260_+|MocE
MNDQWIDVCAVGDIDEEDVLRFDHGAHTYAVFRSAENEFFATAGLCTHEKIHLADGLVMDHVIECPKHNGRFDYRSGKALGAPVCVNLQTYPVRVEAGRVLLAVTAC
>CP027725.1|AZE94293.1|2382259_2383459_+|Ferredoxin-reductase
MDASLIIVGAGHAGGRAALTLREEGYSGRLILIGDEPHVPYERPPLSKGLLQGSQDLAGYSLCDSVRLAELGIEHIAGNAVSRLAPPQHRLQLADGRWLPYSALLLATGGRARRLPQAQPNVLYLRTHDEALALREQLRPGTRLVVVGGGFIGLEVAAAARGLGCAVTVLEAGPRLAGRVLPAIISDALLALHRERGVDVRLNVALASIEAQAVHLADGQTLPCDLVVVGIGMQPNLELAAAAGLEVGQGIRVDAQLRTSAADIYAAGDVCEFRLGGLYQRQETWRNAEAQGRHAALNLLGRALPFEALPGFWSDQYDWGLQTVGVMTPSVVSRPLSDGGLLLFYLDDHGLLQGACGWAPGNRVARDIKLCERLIAARVPLSSAALADPAVSLKQWLRG
>CP027725.1|AZE94294.1|2383460_2384348_+|hypothetical-protein
MRQLLVFQSLWAMQTEPGPLEAQLDRIAAAGFDGITDHYWQAAEVARLHAATAARGLQIEGQLFPQTVDDLGRALEMISRYGCHHLTLQADVRPRTQAEAGRLIEGWQRLAEQVDFPILLETHRYRLTSDLLFTLDLLAQMPDLKLLADLSHYVVGRELPEPGAADDDEQIRTILRHSWGFHGRVASSEQGQVALDFPQHQPWVERFLGWWRYGIEDWLTRAETPRSLSFTCELGPPPYAITGADGRELSDRWAEALKLKALIRQVWDRSLATTQHQASNPVLTATIKNTPSSAR
>CP027725.1|AZE94295.1|2385207_2385846_+|hypothetical-protein
MFQDFGQGRSLSAIGSANRKVGQCIGLACAFVNNGALRFFTESPMPETTVELIQTGPEHAELIRNLYQYYAYESSDWEQEDVEADGRFYIHDEHLARYWQDPQWSANLLLVDGYIAGFLLIEGSELPGIDALELADLFILKRYRRKGIGRAIATQVLCSGEDNWLVRFYDQDEVSQAFWRTVLDNLPRPVQTLELDDEQQLVSYLVTRASLH
>CP027725.1|AZE94296.1|2385834_2386797_-|Transcriptional-regulator,-AraC-family
MHSVALMVYPNFQSLSLSLGSVFECANLLRGEPAYAFHLVSESGGAVMTSQGFSVNTTAIRPEGYDTLIVSGYLEFRLPEANLMEMVKAASAQSRRVASLCMGIFVLAEAGLLDGKRTTTHWIHAPAFRKRYPHIHLEEDKLFVVDGQVWTGAGMSAGVDLALAMVENDLGSDLARRIARKLVIAQRRGSEQSQLSALLELDPKSDRVQLALAYARENLKHDLSVDALADVARLSPRQFSRVFREETGQTPAKAIEALRVEAARAMMETSRHPVEVVARETGFGDRERMRQAFLRAFGQPPQAMQQVLFSPAPAQGRSMQ
>CP027725.1|AZE94297.1|2386970_2387600_+|Transcriptional-regulator,-AcrR-family
MSSETRSARQTILDRAQAIVGAKGFSAVGLNEILQAAEVPKGSFYHYFTSKDAFGVVLLDTYFDHYIEGMQQLFSQPGLSHYARLMRYWQGWIDNHTGCTDAGKCLAVKLGAEVSDLSEPMRLALQRGTSRTIELLAMALQHGVQDGSLMLEHSPESLARRLYALWLGTSVMGKITRTTAPFDEALGLTRQLLGHPENPVIHHDRGTGK
>CP027725.1|AZE94298.1|2387596_2388274_+|ThiJ/PfpI-family-protein
MKVLMVLTSHDQLGDTGRKTGFWLEEFAAPYYAFKDAGAEVVLASPAGGQPPLDPVSDQPDFQTEQTHRFAADPAAQQALATTLKLESVNADDFDTVFYPGGHGPLWDLAELPVSIALIESFERAGKPIGFVCHAPGALRHVKAVNGEPLVKGRRVTGFSNSEEAAVELTDVVPFLIEDEFKKLGGKYEKGADWQSFVIVDGLLVTGQNPGSSSEVAKALLKLTA
>CP027725.1|AZE94299.1|2388368_2389496_+|N-ethylmaleimide-reductase
MAHPLNTPVKLGHHTLNNRIVLPPLTRQRSAQPGDIATDLMATYYRQRASAGFMVSEGTQIEPRGQGYAWTPGIYTPAQIDGWRKVTEAVHAEGGVIFAQLWHVGRVSHNALQPDGAAPVAPSAIQALQAKAFIETAPGLGELKQPPVPRALTVLEIEELVGHYAQAARNALDAGFDGVEIHSANGYLVNQFISAHSNQRDDEYGGTLDNRLRFLREIVEAVCRVVGPERVGVRFSPLFSGTDQERVYIGLVEEDPHHTYIEAIKVLEQSGIAYVSIAEADWDNAPDLPDSFRQAVRSTFSGRIIYAGRYTAERGAKLVQAGLADLIAFGRPFIANPDLPQRIFNGWPLNALKAEGLYGGTEAGYVDYPEYATPD

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Crispr_ID: CP027725_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_5

2555909-2556014

Orphan

Consensus_repeat	Method
ATCCTGGTCGGCCCTAAGGCCGCCATCGGGGGCAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_5

>merge|CP027725|5|2555909-2556014|CRISPRCasFinder
ATCCTGGTCGGCCCTAAGGCCGCCATCGGGGGCAAGCCCCCTCCCACATTTGGGCCGGAATCGACACAAAATCCTGGTCGGCCCTGAGGCCGCCATCGGGGGCAAG

>CP027725|5|5|2555909-2556014|CRISPRCasFinder
ATCCTGGTCGGCCCTAAGGCCGCCATCGGGGGCAAG	CCCCCTCCCACATTTGGGCCGGAATCGACACAAA
ATCCTGGTCGGCCCTGAGGCCGCCATCGGGGGCAAG

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE94437.1\|2567782_2568814_+\|Delta-1-piperideine-2-carboxylate-reductase	unknown	unknown	gnl\|CDD\|376860
CP027725.1\|AZE94434.1\|2561035_2562037_-\|Putative-transmembrane-sensor	unknown	unknown	gnl\|CDD\|226235
CP027725.1\|AZE94423.1\|2550178_2551162_+\|6-phosphogluconate-dehydrogenase,-decarboxylating	unknown	unknown	gnl\|CDD\|236582
CP027725.1\|AZE94422.1\|2549742_2549919_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94421.1\|2547845_2549582_-\|Phosphoethanolamine-transferase-EptC	unknown	unknown	gnl\|CDD\|333729
CP027725.1\|AZE94433.1\|2560286_2560736_-\|Fap	unknown	unknown	unknown
CP027725.1\|AZE94418.1\|2545124_2545337_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94429.1\|2557406_2558150_-\|Fap-system-putative-outer-membrane-protein	unknown	unknown	unknown
CP027725.1\|AZE94428.1\|2556064_2557357_-\|TolA-like-membrane-protein	unknown	unknown	unknown
CP027725.1\|AZE94426.1\|2553557_2553818_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94425.1\|2552678_2553503_+\|Hydrolase,-HAD-superfamily	unknown	unknown	gnl\|CDD\|369792
CP027725.1\|AZE94430.1\|2558187_2558868_-\|Bacteriocin-resistance-protein	unknown	unknown	gnl\|CDD\|239103
CP027725.1\|AZE94427.1\|2554146_2555472_+\|sigma-54-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
CP027725.1\|AZE94431.1\|2558928_2559666_-\|filamentous-hemagglutinin	unknown	unknown	unknown
CP027725.1\|AZE94419.1\|2545480_2547526_-\|Outer-membrane-receptor-for-ferric-coprogen-and-ferric-rhodotorulic-acid	unknown	unknown	gnl\|CDD\|227114
CP027725.1\|AZE94432.1\|2559735_2560287_-\|Fap-amyloid-fibril-minor-component	unknown	unknown	unknown
CP027725.1\|AZE94435.1\|2562184_2562454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379323
CP027725.1\|AZE94436.1\|2562474_2567613_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|199913
CP027725.1\|AZE94424.1\|2551158_2552682_+\|Glucose-6-phosphate-1-dehydrogenase	unknown	unknown	gnl\|CDD\|237233
CP027725.1\|AZE94420.1\|2547522_2547717_-\|Outer-membrane-receptor-for-ferric-coprogen-and-ferric-rhodotorulic-acid	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE94425.1\|2552678_2553503_+\|Hydrolase,-HAD-superfamily	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	2.72008e-68
CP027725.1\|AZE94430.1\|2558187_2558868_-\|Bacteriocin-resistance-protein	gnl\|CDD\|239103	cd02423, Peptidase_C39G, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature.	1.07439e-56
CP027725.1\|AZE94427.1\|2554146_2555472_+\|sigma-54-dependent-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	3.58085e-160
CP027725.1\|AZE94423.1\|2550178_2551162_+\|6-phosphogluconate-dehydrogenase,-decarboxylating	gnl\|CDD\|236582	PRK09599, PRK09599, NADP-dependent phosphogluconate dehydrogenase.	0
CP027725.1\|AZE94421.1\|2547845_2549582_-\|Phosphoethanolamine-transferase-EptC	gnl\|CDD\|333729	NF012179, CptA, phosphoethanolamine transferase CptA.	0
CP027725.1\|AZE94436.1\|2562474_2567613_-\|hypothetical-protein	gnl\|CDD\|199913	cd11007, M35_like_1, Peptidase M35-like domain of uncharacterized proteins. This family contains proteins similar to the M35 Zn2+-metallopeptidases, also known as the deuterolysin family, presumably these are bacterial metalloendopeptidases that have yet to be characterized. Typically, members of this family of extracellular peptidases contain a unique zinc-binding motif (the aspzincin motif), defined by the HExxH + D motif where an aspartic acid is the third zinc ligand; however, members of this family do not contain the GTXDXXYG motif C-terminal to the His zinc ligands that is typical for the M35 proteases. Deuterolysins are highly active towards basic nuclear proteins such as histones and protamines, with a preference for a Lys or Arg residue in the P1' subsite. MEPs specifically cleave peptidyl-lysine bonds (-X-Lys-) in proteins and peptides. Many members of the M35 peptidases display unusual thermostabilities.	1.10887e-10
CP027725.1\|AZE94435.1\|2562184_2562454_+\|hypothetical-protein	gnl\|CDD\|379323	pfam13670, PepSY_2, Peptidase propeptide and YPEB domain. This region is likely to have a protease inhibitory function (personal obs:C Yeats). The name is derived from Peptidase & Bacillus subtilis YPEB.	1.1122e-10
CP027725.1\|AZE94419.1\|2545480_2547526_-\|Outer-membrane-receptor-for-ferric-coprogen-and-ferric-rhodotorulic-acid	gnl\|CDD\|227114	COG4773, FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism].	0
CP027725.1\|AZE94424.1\|2551158_2552682_+\|Glucose-6-phosphate-1-dehydrogenase	gnl\|CDD\|237233	PRK12853, PRK12853, glucose-6-phosphate dehydrogenase.	0
CP027725.1\|AZE94434.1\|2561035_2562037_-\|Putative-transmembrane-sensor	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	8.47324e-73
CP027725.1\|AZE94437.1\|2567782_2568814_+\|Delta-1-piperideine-2-carboxylate-reductase	gnl\|CDD\|376860	pfam02615, Ldh_2, Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	5.46078e-131

>CP027725.1|AZE94427.1|2554146_2555472_+|sigma-54-dependent-transcriptional-regulator
MLVTPAQRRLLVVDPCEDCHGLLPGLRTVGWEVDSCALEAVGERSCDVGLLRLQPCHLERPEAVKELIGRSGTEWIAVISQDVLRLQNVGDFVCEWFFDFHTLPFDVARVQVTLGRAFGMARLRGRGHTPESGPGHELLGDSRPIRELRKLLSKLAPTESPVLIRGDSGTGKELVAKTLHRQSQRHARPFVAINCGAIPEHLIQSELFGHEKGAFTGAHQRKVGRIEAAHGGTLFLDEIGDLPMELQANLLRFLQEKQIERVGGSQPIPVDVRVLAATHVDLEAAVEKGTFREDLYYRLNVLQVVTAPLRERHGDVAMLANHFSRFYSQETGRRPRSFSEAALVAMGQHPWPGNVRELANRVRRGLVLAEGRQIEAVDLGLQGAQAVSPSMATLEDYKHRAERQALCDVLHRHSDNLSVAARVLGISRPTFYRLLHKHQIR
>CP027725.1|AZE94426.1|2553557_2553818_-|hypothetical-protein
MNAPLRINEALLIADRAFQPFQCVAWHDGHGALSLSVIDRTNTRIGSKQLSSTTYTDPAQLEDLLLQARAELDKDGYQLQQWAMPK
>CP027725.1|AZE94425.1|2552678_2553503_+|Hydrolase,-HAD-superfamily
MSDAAIHPIGFILSDVDGTLLHPDHSLSQRTADAVRALREAGVLFSLASGRPPKAMMHLIDTFGIDVPVAGFNGGTLINPDGSILVAHHLPAEAALVTLALFSAEPDVEVWVFADGDWLRRDPPGPMAQREAEGLGYGPVVVESFEPYLDRVDKIVAASNNTQLLVELEARLHPKVQGLAQVSRSQPVYLDVTAMLANKGEALKTLAAHLGVPLEQTAAIGDGGNDPAMFHVAGLSIAMGQAEETVKRQASVVTGSNVEDGAAEAFERFILNVR
>CP027725.1|AZE94424.1|2551158_2552682_+|Glucose-6-phosphate-1-dehydrogenase
MTANGKKPKAEPAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLLGDGLRIVGVDHNAISDADFAKKLEDFIRTEAAGKVRGNAENALDPQLWAQLAKGISYVEGDFLDDSTYAAIAQKIADSGTANAVFYLATAPRFFSDVVQRLGSAGLLNETDEGFRRVVIEKPFGSDLATAEALNACLLKVMSEKQIYRIDHYLGKETVQNILISRFSNVLFEAFWNNHYIDHVQITAAETVGVETRGNFFEKTGTLRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWSLEDARANSVRGQYTAGEIAGKQLPGYREEANVAPDSSTETFVALKVMIDNWRWVGVPFYLRTGKRMSIRDTEIVICFKQAPYAQFRDTDVDELKPTYLKIQIQPNEGMWFDLLAKKPGPTLEMANIELGFDYKDFFEMQPSTGYETLIYDCMTGDQTLFQRADNIENGWRAVQPFLDAWKEDDGIQAYKAGEDGPAAADALLARDGRTWHSLG
>CP027725.1|AZE94423.1|2550178_2551162_+|6-phosphogluconate-dehydrogenase,-decarboxylating
MQLGIIGLGRMGGNIARRLMLNGHTTVVYDRNEAFVKGLSEEGATGVADLKALVAGLQKPRAVWVMLPAGAPTEDTINELSGLLESGDVIIDGGNTNYKDDVRRGRALAEKGLHYVDVGTSGGVWGLERGYCMMIGGDVETVQRLDPIFKSLAPGIGSIPRTKDRSAAADPRAEQGYIHAGPAGSGHFVKMIHNGIEYGMMQAFAEGFDILKTKNSENLPEDQRFDLNVADIAEVWRRGSVVSSWLLDLTADALATDPKLDGYSGSVADSGEGRWTIEAAMEQAVPVPVLSTSLFARFRSRQQSTYGDKMLSAMRFGFGGHVETSKK
>CP027725.1|AZE94422.1|2549742_2549919_-|hypothetical-protein
MSTAQMTRPPQTLYVSIRRDELRQLKDERDQLQQEVLRLRSHLQAQLELPSGAKPALC
>CP027725.1|AZE94421.1|2547845_2549582_-|Phosphoethanolamine-transferase-EptC
MFKRSTTTAKGFDWAGLGWLFLFFWYFSGITQLLIQLTGTSGFSGFRQAFFMSALWLAPMLLFPRQTRVLAAVIGVVLWACSMASLGYFFIYQQEFSQSVIFIMFESNISEAGEYATQYFAWWIVLAFLAHTAFAVFLWTRLRPVYLPRGQSIVAAIAIVLAIVGYPLVKQIATSDTMEQAIDRFETRIEPAVPWQMIVAYRRYTEQLDNMQGMLTSASQIPPLKNLKDSMAGQPSTLVLVIGESTNRQRMSLYGYPRNTTPELDKLRDQLAVFDNVITPRPYTIEALQQVLTFADEENPDLYLKTPSIVSVMKQAGYKTFWITNQQTMTKRNTMLTTFSEQADEQVYLNNNRNQNARQYDGDVLAPFSKALADTAERKFIVVHLLGTHMSYQYRYPQTFDKFTDRQGVPPGVSDAQLPTYNSYDNAVLYNDFVVSSLIKDYAKTDPNGFLLYLSDHGEDVFDSAGHDTLGRNEGKPTAPMYTIPFMAYASPKWRENHDWSFAGDLQRPYSSSQLIHTWADLAGLSFDELDRSKSLVSDSFKPRPLLIGNPYETKQKALIDFSLIKPKKADSTDVVVK
>CP027725.1|AZE94420.1|2547522_2547717_-|Outer-membrane-receptor-for-ferric-coprogen-and-ferric-rhodotorulic-acid
MLAPFTRSISVTLGLFSLALSPELLAETDPEQPPPAPSNWTPPASLPKAWARPPSTPAPTPQAR
>CP027725.1|AZE94419.1|2545480_2547526_-|Outer-membrane-receptor-for-ferric-coprogen-and-ferric-rhodotorulic-acid
MSTATRLNLSVKETPQSISVITRQQMDDFNLNTLTDVLRQTTGINVQHNDSDRVSYTSRGYGINNFQIDGMLNTFGYMKSDADTIIYDRIEVVRGATGLTTGAGDPSATVNMVRKRPTAQWQAKTGISGATHDNYYSYLDVGGPLAFDGRLRGRSVLAYRDSQSFRDNYALQRAVGYGILEGDLSDDTVLAVGFDYQDKQVQGTSWGTVPYWNSQGGKARLSRSTNMAAHWSSWPLTDKTTFATLDHRLGGDWHLKAAYTHRQSDTDGKVYYGGAGFPNADRSGMTAWASHMRGTSRMEAIDLNLAGSYALLGREHQLMMGYGEAAQRDSSPFMRSNLPKGYYTIEDWKHMGGIGKFTDDVTDLKGEHSKKQQKAGYLATRLSLTDRLHAVLGSRYGSWELESATPQYDANDQLTASGKTGQTHNDMWTPYAGLLYDITPQYTVYASYTDIFKPQSARDVNKKYLEPVVGSNYEIGLKGSVLNERLNLAAAYFWSTQDNVAERDDSVPPNPATGEEFYKSGGKGNKVKGFELEAAGEIAPDWNLTAGYTYTHSVNGAGQRNNTGQPLNLLKLSSAYRLPGAWRNLTVGGAVTWQSDIFDFGNRPTGQRDDQGDPITTRAKIEQQGYTVVNLMSRYQFDEQLTASINVNNLFDKKYYERVGFYNGVYWGDPRSITLALDWRL
>CP027725.1|AZE94418.1|2545124_2545337_-|hypothetical-protein
MKLSTLMLASLMTLTSAAAFAEGGSERSKEFYNNFSFIQETTHGKAEQQVVSADGKPVKATTAEPAQPNS
>CP027725.1|AZE94428.1|2556064_2557357_-|TolA-like-membrane-protein
MHRSLSLRAMVCLSTLLPTSVLYAAPDADIETLKQELLELKQRYDVQQKALAVLEQRVRQVEDQPAAPEPRRLAKSPADFKKGATTVAGAAASGGAGGGGSSYGQSLKDDSAPAQSVSNLYNEASGFFGNGKFSVETGITYARYDARQLTLNGFLALDSIFLGNINLDRIKSDSWTLDLTGRYNVDNRWQFDLNVPVVYRESTYQSGGAGNDATATSEASVTRDPTIGDVNVGVAYKFLDETPTLPDAVVSVRVKAPTGKEPFGIKLVRQPNNDNLYLPESLPTGNGVWSVTPGISLVKTFDPAVLFGSLSYTHNFEDSFDDISSEVNQKVGGKVRLGDSFQFGVGVAFALNEKMSMSFSVSDLVQRKSKLKPDGGDWQSVVSSDANAGYFNVGMTIAASDNLTIVPNLAIGMTDDAPDFTFSLKFPYYF
>CP027725.1|AZE94429.1|2557406_2558150_-|Fap-system-putative-outer-membrane-protein
MNTSRWLTVVCLAASMPAYASSGFKPIELNDAQMAELRGRYVMPGRIISFGIVMSSTWTNAVGDSITGKASMQLDKTTVTPQFYVQTSGAAGSGTPTTGSGNVIGGAGLGSGQGVIQSVRTAGDGNTAYNSVGINVTQDGFAPANALQSGQVLVAGGTVTGDSQAGHVSVSADNGGLQMTIQANHNQGNSLQQIGGGNVLQGTVLTGDTNVVSNMTQLNVVMNPNGMNSGALNCNLDQLKGLRTLGY
>CP027725.1|AZE94430.1|2558187_2558868_-|Bacteriocin-resistance-protein
MRLATLTLLMMLTGPAWAGTMAISAMPGGAVIFKKVESIRERRFANLVEQKTDFSCGAAALATILRQAYWLDVDEDHIIKGMLVTADQDLVRTQGFSMLDMKRYLESIGMRARGYKIAPDTLVTVKIPVVVLLEIRGYKHFVVMQRADKDWVYVGDPVLGHKRYSRDDFVKGWNGIVFAVLGEGYDKANVLLDPPAPLTAKNRLNEFRPVGDAELMDFGFIQSDFF
>CP027725.1|AZE94431.1|2558928_2559666_-|filamentous-hemagglutinin
MKPQMALKPLVFALAALMAAAAQAGGGWHPAPQPTGTVAAVVTDVQKSEHNKFDDSNTENNASADNSVTGNSGNVGVNVQSGSGNQADNAGAISSAKGDFASVFAVIDVNQASTNNNLINKGTQNNASLDSSVNGNSGNVGYNGQAGQGNQGKNNLAITTADGKNIAAASNTEQNSLNNSYLNTAVSSHGYGKPQYVSNNSSLDNSVNRNSGNVGVNLQSGAGNQGSNSLSIGQGCSVCSSGVRF
>CP027725.1|AZE94432.1|2559735_2560287_-|Fap-amyloid-fibril-minor-component
MRRLLLIFALLGSASSMADNTAVIDSSGKQYEGVLSINQAAGSRQQMSNSRAIVLAGQATTVNIQKLDGKVDPSLNAKAAILGTSFTNGNGVLGINQSAGANNQSINAVRISLNPGPQSIDDSVLLQQNTTTLATDSGLTATTGSRQVVTSDQAFTGSRGVIQVNQSAGVGNRVANTLGITIK
>CP027725.1|AZE94433.1|2560286_2560736_-|Fap
MNTFTHTSINALLISCVLSAGACLPSHAGDGVIVTGRTVQGHMYGRTSLPDPYPNTANANPSKEVISAITGELSDRDIGSISSGSSLARSVQPNGNLSGPGATPTGMSTLGSGANAGHGSGSAMGGQISDSIQRGMAPLNNLGSMLGGK
>CP027725.1|AZE94434.1|2561035_2562037_-|Putative-transmembrane-sensor
MSEQPLSEAEYDAITDAAAHWCMRLHAEDCSAAERQAFEKWHDAHPLHAFEYAAMLEIWDVADHLPRNTSAPAPAVLPFKPRRRWRTYAAAAAICLGALPLAAFTGWEAGWLPSAYKHYEATDGLRKVTLGDGSQVELNLGTELVYSDYKDRRQVSLKKGEAFFKVSHDGDHPFIVRAGEGQVRVTGTQFNVWTYADQVRVMLLEGSVQIASDSVHGSVPLTPGMQASYQRGDATPHVAAIKPDDTALAWRTGKLVLDNLALADALPLINRYLDKPAMLADAGTGSIRIGGIYNLSEVNNLIPSLPKVLPVYLTQNQDGNPVLNAIPRKTPKG
>CP027725.1|AZE94435.1|2562184_2562454_+|hypothetical-protein
MLKKTLAALCATTALLSAGAALADKPGAGWITIEKAIEVAKTKAGYIEVYAAEADDNGYWEVKGRKSDGTVYEARIDGASGNILRDQKD
>CP027725.1|AZE94436.1|2562474_2567613_-|hypothetical-protein
MTRVTPPYFFDEFLLPVNRSVLSERERALGLTVKDLEWLHGVYYASDASRQDTRLQSHPMRVEKLLINAVGHAAIPLAGAFVMSPTPDGAKALLYTPYGGIQVFDSHAAMLGEVGEALADAVQRVDLISFLSIAQRNSLSAVTDLTLTTSPVPGPVMEDQERTLQACQRANVRSMLEHLQKTPTLSDMLDTLLGIMAHPYFPGLDQRDTRVNCFIQSPTDIDRRWIDSLTLREAFLKFYVKHAWPLGQTREFINPRHVTTHFNQTQLQHDSERWETLIEQTSGTLSKLLDSLLQTYWNKDIDNGTSRLELFAQVLADKFRLDVLLKRQTGILSADESHMLQALCLSDQDARSAYAADLSVEKVRIHARYQHYVELASTLMMHQSHAYLYTQSRGVQVLADLDDLKDTLLTMLTAAGHEDELLNFLSLDERDTFIGLDQINIAARPVTGHVFTGMIEDIAAKQTSNMNHALGLYRSSAGQLDLEALLDYALDIRAMLDSRLADLDTDGRWTIHPVSSGNGRPSTVQAERAKLHQQRLQTAEEGLQIERLKHPTLRSMATLALNTELQTQRLDLKADEVYVNTYASRAEQLEERAPVSSLSMVEHFIERLRPESQPLAVSSRTGFYQNRDRRVALKLNNMTLKTFNNVIERVLKVFAGHELRDLPRLFLDNNRDKHAHSMLLGLRSEAELRLLGKTLPADSHAILDTVLRNDSLVRLTRHGINGFLPDAYALALQQGTSDALLPLANLFVLTERGGLDPRHSGQAILWTPRRGHEVFPSISALREALTQRLAHPVKRLTLLENLRLSHRAPHQVYRLAPLQRIDDNVLDNRLKAYGDNVMDAVDHLLAMDLPARAVQDRLDAILETPAPTNLARAKALADAMITQQLLPVWLAMAPAKEQIYHAELLEQYRNSAPEEEDYLHGIPTLREHAFSALLKLLQARFPGQTISPDDVLIPMHQALNIHEFSLTDFALRHWPDLNNQIIRPRSRTATLLPDALDANAVIQMVRQLDLKSVYQKRVQTELDAGTEAARKRRRRFCRQLPWQVLQYAHEQHLQERLSTQALGWVQQVFDMPDALARAALTGVSTLIRPVELVATEGATAAKVLGMYLISGEDKHPGPVVLYAPYSEHHVLKQYDSEQALLDEVQRPGELQDWVIRHLEDPHQAVYRHLLQNNPHRPSDISLASSAVTGNLLHYLFSENVLVLLKMLACQFEEGAKLLWDKAVGLFGKGIPTAVHFMAGKLAYPLVVWRAYKLVKRSMEALQLHQWKAAMKDFILAVVQMATLYRELDGSEPPPPGHPDAVDLPEDKLPLVAIPGLHDATATSRTRLQRFENHDIALKELELGNASHVYADKARAKAYIPLAGKVYPVTKTKKHWRLGTDDQQGPYVGRNSDGQWVLDLSLHKPRFGQTWTRQRAQRAQRREINIQAQGIKAIAAVSRWKAQAIDEALNVATYYAVNCKRNIRHFAQLLTPDSRVGLFLCDLFGTINLTPDQVRKIETIIDGILDELSDPTLIGPDSMRLVSGESLKDPTNDYAMVLADDSERKVFLFDRFFDPDLTEYANLLNAPFDMFAHARASTLIHELTHLRFKTEDIAYLRSMEPFRDLIDTAKPGAQALRTRQDDLQTTALSTLTPASMLFKTWDDISDTWEDYGVFTTTHYLKRKVLGITGAKTLNEARQIFMSNIDKRIDVILTNADSVTYLITHLGRMLDVGA
>CP027725.1|AZE94437.1|2567782_2568814_+|Delta-1-piperideine-2-carboxylate-reductase
MSAQSPAVVTASISFKELVGLLQRIFVRHGTSPEVAAILAHNCASAERDGAHSHGIFRIPGYLSTLASGWVDGAAVPTVSDVASGFVRVDAGNGFAQPALAAARGLLVSKARSAGIALLAIHNSHHFAALWPDVEPFAEEGLVALSVVNSMTCVVPHGADRPLFGTNPIAFAAPQANGAPIVFDLATSAIAHGDVQIAARKGERLPPGMGVDSLGQPTQDPKAILEGGALLPFGGHKGSALSMMVELLAAALTGGNFSFEFNWADHPGARTPWTGQLLIVIDPSKTAGQSFAERSHELVRQMHAAGLRRLPGDRRHRARAKALETGIELPVQELNQLQEWAGD

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Crispr_ID: CP027725_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_6

3090924-3091014

Orphan

Consensus_repeat	Method
GGGCAAGCCCCCTCCCACATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_6

>merge|CP027725|6|3090924-3091014|CRISPRCasFinder
GGGCAAGCCCCCTCCCACATTTGATCTTCGCTGCTTAAGCATTTCGTTCGCTTAACTGACTGGCATTAGGGCAAGCCCCCTCCCACATTGG

>CP027725|6|6|3090924-3091014|CRISPRCasFinder
GGGCAAGCCCCCTCCCACATTTG	ATCTTCGCTGCTTAAGCATTTCGTTCGCTTAACTGACTGGCATTA
GGGCAAGCCCCCTCCCACATTGG

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE94887.1\|3084835_3084979_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94890.1\|3086978_3088046_+\|putative-ACYL-COA-DEHYDROGENASE-FADE36	unknown	unknown	gnl\|CDD\|270703
CP027725.1\|AZE94892.1\|3088905_3090339_+\|Transcriptional-regulator,-GntR-family-domain	unknown	unknown	gnl\|CDD\|224089
CP027725.1\|AZE94897.1\|3094807_3095677_-\|Rhomboid-protease-GlpG	unknown	unknown	gnl\|CDD\|275075
CP027725.1\|AZE94900.1\|3097692_3098640_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378094
CP027725.1\|AZE94903.1\|3100402_3104164_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235663
CP027725.1\|AZE94901.1\|3098748_3099207_-\|magnesium-chelatase,-subunit-ChlD	unknown	unknown	gnl\|CDD\|224161
CP027725.1\|AZE94896.1\|3094532_3094793_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225681
CP027725.1\|AZE94885.1\|3082768_3084046_-\|Serine-transporter	unknown	unknown	gnl\|CDD\|273283
CP027725.1\|AZE94898.1\|3095673_3096645_-\|Diadenosine-tetraphosphatase	unknown	unknown	gnl\|CDD\|277358
CP027725.1\|AZE94895.1\|3093705_3094536_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378524
CP027725.1\|AZE94886.1\|3084222_3084747_-\|Isochorismatase	unknown	unknown	gnl\|CDD\|238496
CP027725.1\|AZE94902.1\|3099404_3100403_-\|magnesium-chelatase,-subunit-ChlI	unknown	unknown	gnl\|CDD\|274135
CP027725.1\|AZE94889.1\|3085895_3086849_+\|D-3-phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240633
CP027725.1\|AZE94893.1\|3090421_3090823_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380362
CP027725.1\|AZE94894.1\|3091034_3093692_-\|Membrane-alanine-aminopeptidase-N	unknown	unknown	gnl\|CDD\|237585
CP027725.1\|AZE94888.1\|3085506_3085755_+\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE94891.1\|3088068_3088836_+\|Oxidoreductase,-short-chain-dehydrogenase/reductase-family	unknown	unknown	gnl\|CDD\|180802
CP027725.1\|AZE94899.1\|3096644_3097535_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|179257
CP027725.1\|AZE94884.1\|3079916_3082541_+\|Aconitate-hydratase-2	unknown	unknown	gnl\|CDD\|236424

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE94890.1\|3086978_3088046_+\|putative-ACYL-COA-DEHYDROGENASE-FADE36	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	4.40275e-96
CP027725.1\|AZE94892.1\|3088905_3090339_+\|Transcriptional-regulator,-GntR-family-domain	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.16716e-132
CP027725.1\|AZE94897.1\|3094807_3095677_-\|Rhomboid-protease-GlpG	gnl\|CDD\|275075	TIGR04239, GlpG_protein, rhomboid family protease GlpG. GlpG in E. coli is a rhomboid family intramembrane serine protease that has been extensively characterized as a proxy for rhomboid family proteases in animals. It efficiently cleaves eukaryote-derived model substrates. This multiple membrane-spanning protein excludes inappropriate substrates from access to its cleavage site, and shows activity against truncated versions, but not full-length versions, of the E. coli multidrug transporter MdfA. This finding suggests a housekeeping function in removing faulty proteins. In contrast, several eukaryotic rhomboid family proteases release peptide hormones for signaling functions, and the Shewanella and Vibrio protein rhombosortase appears to be part of a protein-sorting system, cleaving a C-terminal anchoring helix domain.	4.27651e-46
CP027725.1\|AZE94900.1\|3097692_3098640_+\|hypothetical-protein	gnl\|CDD\|378094	pfam08907, DUF1853, Domain of unknown function (DUF1853). This family of proteins are functionally uncharacterized.	2.17344e-111
CP027725.1\|AZE94903.1\|3100402_3104164_-\|hypothetical-protein	gnl\|CDD\|235663	PRK05989, cobN, cobaltochelatase subunit CobN; Reviewed.	0
CP027725.1\|AZE94896.1\|3094532_3094793_-\|hypothetical-protein	gnl\|CDD\|225681	COG3139, COG3139, Uncharacterized protein conserved in bacteria [Function unknown].	4.0993e-30
CP027725.1\|AZE94885.1\|3082768_3084046_-\|Serine-transporter	gnl\|CDD\|273283	TIGR00814, membrane_transport_protein_YhjV, serine transporter. The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family- serine/threonine subfamily (TC 2.A.42.2) The HAAAP family includes well characterized aromatic amino acid:H+ symport permeases and hydroxy amino acid permeases. This subfamily is specific for hydroxy amino acid transporters and includes the serine permease, SdaC, of E. coli, and the threonine permease, TdcC, of E. coli.//added GO terms, none avaialbelf or ser/thr specifically [SS 2/6/05] [Transport and binding proteins, Amino acids, peptides and amines].	6.72253e-174
CP027725.1\|AZE94898.1\|3095673_3096645_-\|Diadenosine-tetraphosphatase	gnl\|CDD\|277358	cd07413, MPP_PA3087, Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain. PA3087 is an uncharacterized protein from Pseudomonas aeruginosa with a metallophosphatase domain that belongs to the phosphoprotein phosphatase (PPP) family. The PPP family also includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.03112e-110
CP027725.1\|AZE94895.1\|3093705_3094536_-\|hypothetical-protein	gnl\|CDD\|378524	pfam10977, DUF2797, Protein of unknown function (DUF2797). This family of proteins has no known function.	1.7381e-144
CP027725.1\|AZE94886.1\|3084222_3084747_-\|Isochorismatase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	1.00183e-50
CP027725.1\|AZE94902.1\|3099404_3100403_-\|magnesium-chelatase,-subunit-ChlI	gnl\|CDD\|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	5.43994e-122
CP027725.1\|AZE94889.1\|3085895_3086849_+\|D-3-phosphoglycerate-dehydrogenase	gnl\|CDD\|240633	cd12156, HPPR, Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase. Hydroxy(phenyl)pyruvate reductase (HPPR) catalyzes the NADP-dependent reduction of hydroxyphenylpyruvates, hydroxypyruvate, or pyruvate to its respective lactate. HPPR acts as a dimer and is related to D-isomer-specific 2-hydroxyacid dehydrogenases, a superfamily that includes groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.1246e-134
CP027725.1\|AZE94893.1\|3090421_3090823_+\|hypothetical-protein	gnl\|CDD\|380362	cd02234, cupin_BLR7677-like, Bradyrhizobium japonicum BLR7677 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLR7677, a Bradyrhizobium japonicum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.20522e-46
CP027725.1\|AZE94894.1\|3091034_3093692_-\|Membrane-alanine-aminopeptidase-N	gnl\|CDD\|237585	PRK14015, pepN, aminopeptidase N; Provisional.	0
CP027725.1\|AZE94901.1\|3098748_3099207_-\|magnesium-chelatase,-subunit-ChlD	gnl\|CDD\|224161	COG1240, ChlD, Mg-chelatase subunit ChlD [Coenzyme metabolism].	7.10937e-31
CP027725.1\|AZE94891.1\|3088068_3088836_+\|Oxidoreductase,-short-chain-dehydrogenase/reductase-family	gnl\|CDD\|180802	PRK07035, PRK07035, SDR family oxidoreductase.	0
CP027725.1\|AZE94899.1\|3096644_3097535_-\|NAD-kinase	gnl\|CDD\|179257	PRK01231, ppnK, NAD(+) kinase.	0
CP027725.1\|AZE94884.1\|3079916_3082541_+\|Aconitate-hydratase-2	gnl\|CDD\|236424	PRK09238, PRK09238, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated.	0

>CP027725.1|AZE94893.1|3090421_3090823_+|hypothetical-protein
MKRLLATAAILASLNAYAHEPVYHQETLKVLQEHALANVPGKKTIMLTVDYAPGQATVPHSHTGTAVAYVLEGEITSRVNDEKAITYKAGDSFYEPAGSRHFESSNASQTRPARLLVVMVLDDKAEVLTPLAQ
>CP027725.1|AZE94892.1|3088905_3090339_+|Transcriptional-regulator,-GntR-family-domain
MELHLVINGRKDLAAQLYQQLREAITCGRLSAGAQLPPSRLLAEQLGVSRKTVSDTYATLTYEGLLVGRIGRGTFVNAWAPRPDRVQTATDLACAANLGKWAALPSPMHHPANDEILRYEFIGGATTRNQFPQEEWRRCTLDALRRIARNSGFYSQPEGLPALREAIAGHIAFSRGVKGRAGDIVVTNGAQQALDLIARVVLEPGSIVAMEDPGYSPARQLFVAMGARVASVPVDAQGIQVDQIPDGTRLIYVTPSHQFPLGMPMSLARREALLDRAIALGAIIIEDDYDSEFRYEGRPTDSLQSMDTQGVVTYVGTFSKTLLPELRLGYAVLPPAIHGAVLKAKQLTDQHSSTLPQWALAKFISEGYLLKHIRRCHSVYAGRRERILQRLAGDLSPWFEAVPTVAGFHLAALCKVPVDIPLLMELARKAQVGLYPLDVFFHDTAPRPGLILGFGAIETLDIDPALDKVRDILRQIG
>CP027725.1|AZE94891.1|3088068_3088836_+|Oxidoreductase,-short-chain-dehydrogenase/reductase-family
MSKTHLFDLDGKIAFVSGASRGIGEAIAKLLAQQGAHVIVSSRKLEGCQHVADAIIADGGKATAVACHIGEMEQIAQVFAGIREQFGRLDILVNNAATNPQFCNVLDTDLGAFQKTVDVNIRGYFFMSVEAGKLMRDNGGGSIINVASINGISPGVFQGIYSVTKAAVINMTKVFAKECAAFGIRCNALLPGLTDTKFASALVKNDAILKMALAQIPLKRVADPSEMAGAVLFLASDASSYTTGVSLNVDGGFLS
>CP027725.1|AZE94890.1|3086978_3088046_+|putative-ACYL-COA-DEHYDROGENASE-FADE36
MALNDQSTQIRPGEELDASLIDPYLKAHIPGLHGTVKISQFPGGASNLTYLLEYPDQEFVLRRPPFGHKAKSAHDMGREYRILNQLKDGFPYCPKAYVHCTDESVIGAEFYVMERVNGIILRSDLPAELGLDATRTEALCKSFIDMFVELHQVDYTACGLADLGKPHGYVERQIRGWSERYEKALTPDAPRWEAVRAWLNDKMPADHPTSSIVHNDYRFDNVILDPHNPMQIIGVLDWELTTVGDPLMDLGNTLAYWIEAADPAPVQLMRRQPSNAPGMLTRRQFVDYYAERSGIRIDNFDFYYTYGLFRLAGIVQQIYYRFFHGQTQDKRFAQFIHMNTLLEQMSLAVIGKSAL
>CP027725.1|AZE94889.1|3085895_3086849_+|D-3-phosphoglycerate-dehydrogenase
MPTTVLVLVETINEYLQIIESNDFHVILAPTPAERAQAIKAHGKQIKAVLTRGPLGLHAEEIAALPLLEIICVIGAGYEHVDLQAAANRGIVVTNGAGVNAPSVADHAMALLLSLVRGIPQTDAAVRRDEWPKVMRPSLGGKQLGILGLGAVGLEIARRAALGFGMEVSYHNRQPRDDVDYTYCSTAVELARTSDFLILATPGGAGTRHLIDRHALDALGPNGFLVNIGRGSVVVTADLVAALEQRRIGGAALDVFDDEPKVPDALKRLGNTVLTSHVAGLSPEATHDTVQRVADNLVEYFAGRPVLTPVALPAPDK
>CP027725.1|AZE94888.1|3085506_3085755_+|hypothetical-protein
MAEQEFFKAFPPEGVEIVSWNIAMGIGHVIVLRFPASRLTEVNLAVERSAWGPFKTEFFPTYDYMHIVSAEQAKVRKPAPAK
>CP027725.1|AZE94887.1|3084835_3084979_-|hypothetical-protein
MTGLLKKLTAPGVSLHDRPMSRIPLNLTRTTTTTAFGGLCGCRVGMS
>CP027725.1|AZE94886.1|3084222_3084747_-|Isochorismatase
MAEALLIIDMQTGLYDGPDRPFDRERLLTNINQLARRARRVNVPIFFARHTGPAGSPIEAGSPAWQLWHELDVDETRDQFFNKTRPSCFLGTELAQQLAAAQVDELVIVGMKTQFCIDTTCRVAVELGFSVVLPEDGHTCMDTPALSARAIIDHHNATLAGAFVRRVKLADIWS
>CP027725.1|AZE94885.1|3082768_3084046_-|Serine-transporter
MNDQANSVDERYATTPATLTSWSRQDTTWMLGLFGTAIGAGTLFLPINAGLGGFWPLVILALLAFPMTFFAHRGLTRFVLSGREGSDITDVVEEHFGLKAGALITLLYFFAIFPILLIYSVALTNTVSSFMEHQLHIMPPPRAVLAFVLILGLLAVVRCGEQAIVKAMSLMVYPFIVALLFLAVYLVPHWNGGILSTASEIPAPSALLSTLWLAIPVMVFSFNHSPIISAFAVDQKRQYGAHADERSSQILCRAHLLMVAMVLFFVFSCVLTLSPAQLAEAKAQNLSILSYLANHFDNPTIAFAAPLIAFVAIAKSFLGHYIGASEGLKGLVLKTGRRPAAKSLDRMTAAFMLVVCWIVATLNPSILGMIETLGGPVIASILFLMPMYAIRKVPAMARYRGQASNVFVTAVGLVAITALVYSLVA
>CP027725.1|AZE94884.1|3079916_3082541_+|Aconitate-hydratase-2
MRVITVLEAYRKHIEERAALGIVPQPLNAEQTAGLVELLKNPPAGEEEFLVDLITNRIPPGVDEAAYVKAGFLSALAKGEATSPLIDKKRAVELLGTMQGGYNIVTLVELLDDAELAPVAAAQLKHTLLMFDAFHDVAEKARNGNEHAKGVIQSWADGEWFRNRPVLADKISLRVFKVTGETNTDDLSPAPDAWSRPDIPLHALAMLKMAREGIVPDEQGKTGPMKQIEEMRGQGFPIAYVGDVVGTGSSRKSATNSVLWFFGDDVPYVPNKRAGGFCFGSKIAPIFYNTMEDAGALPIEFDVTNMNMGDVIDLYPHAGKVCKHGTDEVITTFEMKTPVLLDEVRAGGRIPLIIGRGLTDKARAELGLGPTDLFKLPEAPVDTGKGFTLAQKMVGKACGLPEGKGVRPGTYCEPKMTTVGSQDTTGPMTRDELKDLACLGFSTDLVMQSFCHTAAYPKPIDVTTHHTLPDFIMTRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPMGISFPAGSGLVAFAAATGVMPLDMPESILVRFKGKMKPGITLRDLVHAIPYYAIQAGLLTVEKKGKKNAFSGRILEIEGLNDLTLEQAFELSDASAERSAAGCTIKLSKDSVTEYLNSNITLLRWMIGEGYGDARTLERRAQAMEAWVANPELMEADADAEYAEIIEIDLSEINEPILCAPNDPDDARLLSSVAGEKIDEVFIGSCMTNIGHFRAAGKLLEQVKGQLPTRLWLSPPTKMDAHQLTEEGYYGIYGKAGARMEMPGCSLCMGNQARVEPNSTVVSTSTRNFPNRLGDGANVYLASAELAAVASTLGRLPTVEEYMGYAAKLDTMASDVYRYLNFDQIAEFRKIAASANIPVIQA
>CP027725.1|AZE94894.1|3091034_3093692_-|Membrane-alanine-aminopeptidase-N
MRTEQPKMIYLKDYQAPDYLIDETHLTFELFEDHSLVHAQLVMRRNPERGAGLPPLVLDGQQLELLSVNLADQPLTDAAYQLTDSHLTVHPRSETFTLDTTVKIHPETNTALEGLYKSGGMFCTQCEAEGFRKITYYLDRPDVMSVFTTTVIAEQHRYPVLLSNGNPIASGPGEDGRHWATWEDPFKKPAYLFALVAGDLWCVEDSFTTMTDREVALRIYVEPENIDKCQHAMTSLKKSMRWDEQAYGREYDLDIFMIVAVNDFNMGAMENKGLNIFNSSAVLARAETATDAAHQRVEAIVAHEYFHNWSGNRVTCRDWFQLSLKEGFTVFRDSGFSADMNSATVKRIQDVAYLRTHQFAEDAGPMAHAVRPDSFIEISNFYTLTVYEKGSEVVGMLHTLLGAEGFRKGSDLYFERHDGQAVTCDDFIKAMEDANGVDLTQFKRWYSQAGTPRLAVSESYDAAARTYSLTFRQSCPPTPDKVEKLPFVIPVELGLLDAAGAGIALRLAGEATVGATSRVISVTEAEQTFTFVDVAEKPLPSLLRGFSAPVKLSFPYDRDQLMFLMQHDSDGFNRWDAGQQLSVQVLQELIGQHQAGQPLKLDQRLIDALRTVLSDESLDQAMVAEMLSLPSEAYLTEISDVADVEAIHAAREYARKQLAENLFEGLWLRYQANRDLSRQTPYVAEAEHFARRALQNIALSYLMLSGKPEVLAATLDQFDTSDNMTERLTALAVLVNSPFDAEKAQALAVFAENFKDNPLVMDQWFSVQAGSTLPGGLARVKALMEHPAFTIKNPNKVRALIGAFAGQNLINFHAADGSGYRFLADLVIQLNTLNPQIASRQLAPLTRWRKYDAARQALMKAQLERILGSGELSSDVFEVVSKSLA
>CP027725.1|AZE94895.1|3093705_3094536_-|hypothetical-protein
MIEIGRGAVSKMSAKLGEPTVQYAFRLGDTEVPVNPLIGTHIRLEYLGAIHCSHCGRKTKNSFSQGYCYPCMTKLAQCDLCIMSPERCHYDAGTCRDPGWGETFCMTDHVVYLANSSGIKVGITRATQLPTRWLDQGASQALPIMRVATRQQSGFVEDLFRSQVADKTNWRALLKGDAQSVDLKQVRDELFAACAEGLLGLQERFGLQAIQTIADVEPIEIRYPVEQYPAKIVSFNLDKNPIAEGTLLGIKGQYLIFDTGVINIRKYTAYQLAVHQ
>CP027725.1|AZE94896.1|3094532_3094793_-|hypothetical-protein
MSSFAEMIENITPDIYESLKLAVEIGKWSDGRKLSAEQRELSLQAMIAWELQNLPEDQRTGYMGPQECASKSAPVPNILFKSDAIH
>CP027725.1|AZE94897.1|3094807_3095677_-|Rhomboid-protease-GlpG
MSTVAVLRLPLSVDLGGFVKLLQRMQVPHRVSEEAGEQVLWVPETISDDVRVLYQRFPAGDPDQQLDIPEQAPVARPGFIQQVRHSPVTALVLLASLIVGAVTLLGENLQTMAWLTFLPFRVLGEYIQFTPLADSLASGQWWRLVTPMLIHFGILHLAMNGMWYWELGRRIEARQGGINLLGLTLLFSLASNYAQYAYGGPGLFGGLSGVLYGLLGHCWIFQLLSPNPAYRLPRGVLVMMLVWLLLCLSGLVSMIGFGEIANAAHVGGLVIGCLTGLLGGLYNRRKSSI
>CP027725.1|AZE94898.1|3095673_3096645_-|Diadenosine-tetraphosphatase
MLDPARSYDLIGDVHGCAHTLEHLLEQMGYHKQGGTWRHPSRMAVFLGDIIDRGPRIREALHIVHDMTEAGQALCIMGNHEFNALGWSTPAPPGSGKQFVREHNPRHARLIQETLTQFEQHPADWHDFLGWFYDMPLFVDAGRFRVVHACWDEGFIQPLRATFPDGCIDQHFLQAAAVPGSFACNAFDRLLRGTDMRLPHGLTLTGGDGLTRSFFRTKFWEDDPKTYGDIVFQPDALPEPVARTPLSSTEKNSLLRYGVDEPLLFVGHYWRSGKPAPIRPNLACLDYSAVLYGKLVAYRLDQEARLDPHKFVWVDVERPEVIQ
>CP027725.1|AZE94899.1|3096644_3097535_-|NAD-kinase
MEQFRNIGIIGRLGSTQVLDTVRRLKKFLLERHLHVILEDTIGEILPGHGLQTSSRKMLGEVCDMVIVVGGDGSLLGAARALARHNVPVLGINRGSLGFLTDIRPDELEVEVAKVLDGHYLVENRFLLQAEVRRHGEAIGQGDALNDVVLHPGKSTRMIEFELYIDGQFVCSQKADGLIVATPTGSTAYALSAGGPIMHPKLDAIVIVPMYPHMLSSRPIVVDGNSELKIVVSKDMQIYPQVSCDGQNHFTCAPGDTITVSKKAQKLRLIHPLDHNYYEVCRTKLGWGSRLGGGGD
>CP027725.1|AZE94900.1|3097692_3098640_+|hypothetical-protein
MTLFPDLHALPRQLRHPEVRDLAWVMLAPPMLAQTPWPQRHPLAGSDWVQAPKVLEAWLRALDQDSRALQQWLSLSRTRRLGLYYERLWQFAVQHAPGVELLAANLPIRRAGHTLGELDMLLRDRDGVHHLELAIKLYLGPQHGNGQDTAQWLGPGCHDRLDRKLTHLAQHQLPISARPESREALAALDIQQFDAHLWLGGYLLYPWPGQADPPLGAHPQHLRGRWLHQRDWPDFASTRPAGRWQPLPRHAWLAPAHYPADEVWSEERMEGWLADLDPMAPAQLLVRLVENGEDWEEAERLFLVADLWPNVPGAG
>CP027725.1|AZE94901.1|3098748_3099207_-|magnesium-chelatase,-subunit-ChlD
MIVDASASTRRHRALSDAKGLLAQLFDDAYRQRARLALLTASGQAPKWQVQGLKAAKSLAHWLEQLGAGGGTPLLAALTEAGHWLVARRKRYPAEQQRLMVITDGRLKAIDGLPLLGCPGLLVDIERGPIRLGRARELAMGLQLDYRHIDDV
>CP027725.1|AZE94902.1|3099404_3100403_-|magnesium-chelatase,-subunit-ChlI
MTDSAHFPLAAVVGADELKLALCLNAIDPRIGGVLIEGPRGMAKSTLARGLADLLGSGQFVTLPLGATEERLVGTLDLDAALGEGRAQFSPGVLAKANGGVLYVDEVNLLPDHLVDLLLDVAASGTNLIERDGISHRHAARFVLIGTMNPEEGELRPQLLDRFGFNVALSGQTLPAERGQIIRRRLDFDSDPVAFCEQWAEPQAALRERCIQARACLDGIELDDQALAQITQRCFAAGVDGMRADLVWLRGARAHAAWRGAGAIAEQDIDAVAEFALRHRRQEQAPAASPPSQAQAPQSSNPSPGQGQWGDMPAPALPTGARRDVPAWPKKP
>CP027725.1|AZE94903.1|3100402_3104164_-|hypothetical-protein
MHLLRTQPGGFVADDNIADLGQTPAELVILCSGDSSLALLAEAAQQLPEDYPSLRLANPMQVQNHASVDLYVDEVLRHAKVILISLHGGIGYWRYGIERLVELAERGITLILVPGDDRPDPELSGLSTVDAAQRDRLWQFLRQGGLGNALDFYRCLASGYLGRDYPWTEPQSLPRTSIYHPRTANAELGHWQADWHADFPVAAVLFYRSHLQAANTGFIDVFCQRLQAAGLNPLPIAVASLKEPGCLAVVEDWLDEVQAAVILNTTGFAQSSPEAPHLRPFRRNIPVIQAICAQDNQPGWQASAQGLGPRDLAMHIALPELDGRIISRPISFKDLAWRSERSQSDVVCYRAAPERMDFVADLARRWVELARLPNAHKRVALILANYPTRDGRIGNGVGLDTPAAALNILRALQAEGYPVPSTLPDSGTALIHALLGGVTNDLDSLDLRPCHQSLGLDDYAVMFQRLPEANRQAVLERWGAPHQDPMCRDGRLMIAGLRLDQTFVGIQPARGYQVDQSAVYHDPDLVPPHGYLAFYFWLRQTYGAHALIHVGKHGNLEWLPGKGVGLSENCWPDVLLGPLPNIYPFIVNDPGEGAQAKRRTQAVIIDHLMPPLTRAETYGPLRDLELLADEYYEAQLLDPRRARELQKDILKLVRETRIDQELELDGEADADVWLPRLDTYLCDLKESQIRDGLHVFGESPAGRLRIDTLLALLRIPRGDGRGAQSSLLRVLAKAFELGFDPLDCALAEPWTGRRPEVLRQLDAQVWRTAGDTRERLELYATRLIEQALEGPLEQLEEAGWEEVKAVVESLRMVVAPRLDACGPAEMRGLLDALGGRFVPAGPSGAPSRGRLDVLPTGRNFFTVDVRNLPTTTAWRIGFQSANLLLERHLQDHGDHLRQLGLSVWGTATMRTGGDDIAQAMALMGVRPVWATGSQRVDDFEILPISLLDRPRVDVTLRVSGFFRDAFANLIRLFDAAVQAVAALDEPDDMNPLAAKVRSERLALLESGLDAEAAAKQAGWRIFGAKPGAYGAGVQGAIDGRLWQSREDLAEVYLNWGGYAYGGADEGTAARGQFAQRLSQVQAVLQNQDNREHDVLDSNDYYQFQGGMLAAVETLSGDKAASYHGDHSQPDLPRIRTLKEELNRVVRSRAANPKWIEGVKRHGYKGAFEMAATVDNLFAFDATTALIDDHQYALLADAYLLDPDTRAFVQQHNPDALRDMTERMLEAQQRGLWQEPGAYREALENLLLDMEEDS

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Crispr_ID: CP027725_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_7

3555193-3555288

Orphan

Consensus_repeat	Method
GAGGCCGCCATCGGGGGCAAGCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_7

>merge|CP027725|7|3555193-3555288|CRISPRCasFinder
GAGGCCGCCATCGGGGGCAAGCCCCCTCCCACATTTGGACCGGGATCGACACAAAAGCCCGGTCGGCCCAGAGGCCGCCATCGGGGGCAAGCCCCC

>CP027725|7|7|3555193-3555288|CRISPRCasFinder
GAGGCCGCCATCGGGGGCAAGCCCCC	TCCCACATTTGGACCGGGATCGACACAAAAGCCCGGTCGGCCCA
GAGGCCGCCATCGGGGGCAAGCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE95315.1\|3559029_3560193_+\|Isovaleryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173845
CP027725.1\|AZE95303.1\|3541534_3542986_-\|Outer-membrane-factor-(OMF)-lipoprotein-associated-wth-EmrAB-OMF-efflux-system	unknown	unknown	gnl\|CDD\|273830
CP027725.1\|AZE95307.1\|3549171_3549822_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|379228
CP027725.1\|AZE95321.1\|3565934_3566150_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE95311.1\|3553851_3554787_+\|Transcriptional-regulator,-LysR-family	unknown	unknown	gnl\|CDD\|176109
CP027725.1\|AZE95319.1\|3564670_3565363_-\|cI	unknown	unknown	gnl\|CDD\|224885
CP027725.1\|AZE95305.1\|3543693_3547380_-\|Inner-membrane-component-of-TAM-transport-system	unknown	unknown	gnl\|CDD\|225463
CP027725.1\|AZE95318.1\|3562748_3564674_+\|Methylcrotonyl-CoA-carboxylase-biotin-containing-subunit	unknown	unknown	gnl\|CDD\|227111
CP027725.1\|AZE95310.1\|3552454_3553684_-\|Acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173844
CP027725.1\|AZE95320.1\|3565492_3565786_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371447
CP027725.1\|AZE95316.1\|3560204_3561812_+\|Methylcrotonyl-CoA-carboxylase-carboxyl-transferase-subunit	unknown	unknown	gnl\|CDD\|178415
CP027725.1\|AZE95309.1\|3551000_3552332_+\|Phosphate-binding-protein	unknown	unknown	gnl\|CDD\|270371
CP027725.1\|AZE95317.1\|3561945_3562752_+\|Methylglutaconyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|168168
CP027725.1\|AZE95314.1\|3557233_3558871_-\|Acetoacetyl-CoA-synthetase-(leucine)	unknown	unknown	gnl\|CDD\|236236
CP027725.1\|AZE95304.1\|3542982_3543456_-\|Transcriptional-regulator,-MarR-family	unknown	unknown	gnl\|CDD\|183170
CP027725.1\|AZE95308.1\|3549990_3550803_+\|Exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|236970
CP027725.1\|AZE95313.1\|3555794_3556694_+\|Hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|180206
CP027725.1\|AZE95306.1\|3547379_3549107_-\|Outer-membrane-component-of-TAM-transport-system	unknown	unknown	gnl\|CDD\|223801
CP027725.1\|AZE95302.1\|3540319_3541519_-\|Multidrug-efflux-system-EmrAB-OMF,-membrane-fusion-component-EmrA	unknown	unknown	gnl\|CDD\|185090
CP027725.1\|AZE95312.1\|3555385_3555778_+\|putative-transcriptional-regulator-LiuR-of-leucine-degradation-pathway,-MerR-family	unknown	unknown	gnl\|CDD\|133403

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE95315.1\|3559029_3560193_+\|Isovaleryl-CoA-dehydrogenase	gnl\|CDD\|173845	cd01156, IVD, Isovaleryl-CoA dehydrogenase. Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates.	0
CP027725.1\|AZE95303.1\|3541534_3542986_-\|Outer-membrane-factor-(OMF)-lipoprotein-associated-wth-EmrAB-OMF-efflux-system	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	2.19681e-108
CP027725.1\|AZE95307.1\|3549171_3549822_-\|acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.17553e-05
CP027725.1\|AZE95311.1\|3553851_3554787_+\|Transcriptional-regulator,-LysR-family	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.3821e-68
CP027725.1\|AZE95319.1\|3564670_3565363_-\|cI	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	2.0891e-23
CP027725.1\|AZE95305.1\|3543693_3547380_-\|Inner-membrane-component-of-TAM-transport-system	gnl\|CDD\|225463	COG2911, COG2911, Uncharacterized protein conserved in bacteria [Function unknown].	0
CP027725.1\|AZE95318.1\|3562748_3564674_+\|Methylcrotonyl-CoA-carboxylase-biotin-containing-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
CP027725.1\|AZE95310.1\|3552454_3553684_-\|Acyl-CoA-dehydrogenase	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
CP027725.1\|AZE95320.1\|3565492_3565786_+\|hypothetical-protein	gnl\|CDD\|371447	pfam11275, DUF3077, Protein of unknown function (DUF3077). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	0.000223052
CP027725.1\|AZE95316.1\|3560204_3561812_+\|Methylcrotonyl-CoA-carboxylase-carboxyl-transferase-subunit	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
CP027725.1\|AZE95309.1\|3551000_3552332_+\|Phosphate-binding-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.23052e-68
CP027725.1\|AZE95317.1\|3561945_3562752_+\|Methylglutaconyl-CoA-hydratase	gnl\|CDD\|168168	PRK05674, PRK05674, gamma-carboxygeranoyl-CoA hydratase; Validated.	0
CP027725.1\|AZE95314.1\|3557233_3558871_-\|Acetoacetyl-CoA-synthetase-(leucine)	gnl\|CDD\|236236	PRK08315, PRK08315, AMP-binding domain protein; Validated.	0
CP027725.1\|AZE95304.1\|3542982_3543456_-\|Transcriptional-regulator,-MarR-family	gnl\|CDD\|183170	PRK11512, PRK11512, multiple antibiotic resistance transcriptional regulator MarR.	8.43199e-21
CP027725.1\|AZE95308.1\|3549990_3550803_+\|Exodeoxyribonuclease-III	gnl\|CDD\|236970	PRK11756, PRK11756, exonuclease III; Provisional.	0
CP027725.1\|AZE95313.1\|3555794_3556694_+\|Hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|180206	PRK05692, PRK05692, hydroxymethylglutaryl-CoA lyase; Provisional.	0
CP027725.1\|AZE95306.1\|3547379_3549107_-\|Outer-membrane-component-of-TAM-transport-system	gnl\|CDD\|223801	COG0729, COG0729, Outer membrane protein [Cell envelope biogenesis, outer membrane].	1.12468e-162
CP027725.1\|AZE95302.1\|3540319_3541519_-\|Multidrug-efflux-system-EmrAB-OMF,-membrane-fusion-component-EmrA	gnl\|CDD\|185090	PRK15136, PRK15136, multidrug efflux MFS transporter periplasmic adaptor subunit EmrA.	3.77412e-137
CP027725.1\|AZE95312.1\|3555385_3555778_+\|putative-transcriptional-regulator-LiuR-of-leucine-degradation-pathway,-MerR-family	gnl\|CDD\|133403	cd04776, HTH_GnyR, Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR. Putative helix-turn-helix (HTH) regulatory protein, GnyR, and other related proteins. GnyR belongs to the gnyRDBHAL cluster, which is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	5.87959e-54

>CP027725.1|AZE95311.1|3553851_3554787_+|Transcriptional-regulator,-LysR-family
MNLSKVDLNLFIVFDAIYTEANLTRAGQIVGITQPAVSNALARLRETFNDPLFVRTAQGMVPTPMAQNIIGPVRNALSLLRVSVQESRIFNPQQAAKTYRISMTDLTEAVILPLLFQRLRRLAPTVVIESFLSKRRETTKELAAGRLDFAVDAPLNTDPQVRHVKLMEDRYVCAMRKGHPMAGKDKFSLDDYLSLTHIHISSRRNGLGHVDLALGKMGIQRKIALRSQHYLMASQVLQQTDMVMTVPERFARRHELHWFNLPVNDVPPVETHLYWHESTDQDPANRWMREQMIELCQQVTAHEKKLDKQQA
>CP027725.1|AZE95310.1|3552454_3553684_-|Acyl-CoA-dehydrogenase
MDFAYSPKVQELRERVSAFMDAYVYPAEPVFERQVSEGDRWQPTAIMEELKAKAKAEGLWNLFLPESELGAGLTNLEYAPLAEIMGRSLLGPEPFNCSAPDTGNMEVLVRYANEEQKQRWLEPLLRGEIRSAFAMTEPDVASSDATNMAARAERQGDEWVINGKKWWTSGACDPRCKILIFMGLSNPDAPRHQQHSMILVPVDTPGVKILRPLPVFGYDDAPHGHAEVLFDNVRVPYENVLLGEGRGFEIAQGRLGPGRIHHCMRSIGMAERALELMCKRSVNRSAFGKPLARLGGNIDKIADSRMEIDMARLLTLKAAYMMDTVGNKVAKSEIAQIKVVAPNVALKVIDRAIQIHGGAGVSNDFPLAYMYAMQRTLRLADGPDEVHRAAIGKFEIGKYVPKELMRGGQ
>CP027725.1|AZE95309.1|3551000_3552332_+|Phosphate-binding-protein
MRLCVLLLLILFPLFAVSVPLPLPDQGPALRIQGSNTIGAALGPALVKGLMEHQGLQGVHSEPAEGANEQRVIGRTRQGKTVIIDVAAHGSSTGFAALKNNSADLAASSRPINDNELVDLEPLGDMKSPGAEQVIAIDGLAIILNPQNRLNTLNTEQLAQIFNGQISSWEALGGSGGAIHVYARDDRSGTYDTFKELVLNRRDKPLAASARRFESSEALSDAVSQDPQGIGFIGLPYVRQAKAVAVVDGDSQPMLPLGSLIATEDYPLSRRLYFYLPLATHNPWAKALVDFAQSSQGQAIVAANGFIAQHVQAIGVEPRASMPEEYQAIVRNAQRLTVNFRFEEGSASLDNKARQDVQRVVAYLKSHGKLHKQVTLVGFGDARNDPQRAALLSKLRAMAVRRELVKSGVILRDIRGFGAQMPVAANTADEGRIKNRRVEVWVY
>CP027725.1|AZE95308.1|3549990_3550803_+|Exodeoxyribonuclease-III
MKIVSFNINGLRARPHQLAALIEKHQPDVIGLQETKVHDDQFPLAEVQALGYHVYYHGQKGHYGVALLSRKEALDVHKGFATDEEDAQRRFIWGTFADENGNPVIIMNGYFPQGESRDHPTKFPAKQRFYEDLQQLLESRFSNDQPLVVMGDVNISPQDCDIGIGADNAKRWLKTGKCSFLPEEREWMARLKNWGLVDSFRHLNPEVTDRFSWFDYRSRGFEDEPKRGLRIDVIMASNGLLPRVKDAGVDYDLRALEKPSDHAPIWLELS
>CP027725.1|AZE95307.1|3549171_3549822_-|acetyltransferase
MPDTSTAAAEIRVLNSGYSREARSLLYQAYRHEPTFAYIFEAERPGYEQRVRATVRELVKQHFFQKLPAIGLFVNDRLIGVALIAPPQRRLGITESWAWQIRMWLSTGVRGTRRYLEYHQAVLACLPAVSVHVLPLLGIHPQLQGQHYGEQLLEAVHNWCAEDPHSSGVVLDTGNSRYLDFYKRQGYEEIGEIAVGPVLEHVFFHPNPQALNAATA
>CP027725.1|AZE95306.1|3547379_3549107_-|Outer-membrane-component-of-TAM-transport-system
MKFPGRFTSGLILLFTSCGAWAQSELDVRIKPSNDALKANIEGYIGGVGDRDEEALLRFSRGAEEQARKAAQALGFYQPRIASDVKGGKNPRLTLTIDPGEPVHLRNVTLRVDGPAASLKAFRVPASDDLKPGAVLNHGHYDDAKRLIQNQASRYGFFSGRFTRQTLSVDPQAGVADIELVYDSGPRYSMGKVSFTGDTPFDEELLQRMVPFKPGTPYDSELVAELNQNLQASGFFDSVRVDASPAASTNDVIPVAVQLDTRKPRTMGLGLGFSTDVGPRGRANWTRHWVNPQGHSYGWEAELSAPRQNVGLWYDIPLDPPLTDKLRFAGGYQNEEIANTDTLSKLLTLGPEWHSKLPSGWTRVISLKYQREEYRLGNDSGLSNLVMPGISYSYLRSDNRIDPHNGYRLMFDSKVAKEGLGSDTNLLYGTATIKGLTTLWDNHRFLGRAQVGGSATNGYKSVPPSLRFFAGGDQSVRGYEYQTLSPENDRGDRIGGRYMVALSAEYQYSITEKWRIATFIDQGNSFNTLDMPSLKTGVGVGVRWVSPVGPIRLDLAHALEDPGGVRLHFSMGPEL
>CP027725.1|AZE95305.1|3543693_3547380_-|Inner-membrane-component-of-TAM-transport-system
MRGLKIAGLALVAILALLLLALWSVLGTQAGSRWALGQVPGLSVENFQGRLGGQWRADHLLWQQDGSRVELNAPIFDWSPGCLLRMTLCINRLDVEQVSLEFAPSAEESDSGPIQLPDLKLPVALQLGDVRIGSLLFNGSEELKGLQLAAHWTSAGLQIDSVRLQRDDLVLDLAGLLQPTGDWPLNATGNLSLPYAPGGAPWTIALKLDGDLLKTLKLDADSSGYLPAKLTGELQPLVENLPAQVHITSESFKPSADLPDTLQLNQLDLSAKGDLSKGYQLLGKAVLPAEKGPVDLQLKGKVNAKGAQIAGLDLRAGDKQSLKLSANLDWQQGFSADAKIDWLDFPWHRLYPVIDEPQVALRSFNGEISYKDGNYLGNLKADLDGPAGKFNVVTPFSGDLKQVFLPELKLSAGQGKAEGHLNLQFADGIAWDTALDLSALNPAYWVAELPGTLAGPLRSKGEFKNEQLKLNADLDLKGRLRGQTAVLAAKAEGAGEQWTLANLDIRLGDNRINGSGSLQQRLAGQIDIKLARLAQLWPQLRGQVNGRVEVAGTLKAPQGKLDLKGQQLAFADNRLQSLNLDANLDSAQRAKLDLKANDIQSGETQVGNLTASAQGDIKNQKVQLALTGPLVKLALALDGNLDKDNWRGRLASGDVQAGGQDWRLQAPAKIERLADGKLTFAAHCWVSGGASLCGEDQRLMPEPKLRYHLKQFPIDSLAAFLPKDFAWQGRLNADVQLDLPASGPKGVVSVDAGGGTLRVRDKGQWLDFPYDTLKLETTLNPKRIDTQLNFRGGKLGELLLQAQINPLPANKPITGNFSLTGLDLAVARPFVPMVEKLNGKLNGNGRISGGLLTPLVNGNVNLVDGEVSGPELPISLEGLNLQAQIAGESVQLNGGWHSGKAGQGSLKGQIDWGRALVVDLSLKGSQLPVTVEPYAVLEVAPDLNISLKDDKLAIAGKVHIPRGDITVRELPPSTVKVSDDTVIVGSQTEAGKPPMAMAMDIDVEVGEDQLNFAGFGLTAKVQGHVHIGDNMDTRGELWLNDGRYRAYGQRLSVRRARLLFAGPLDQPFLDIEAVRVTTEASRTVTAGIRLSGSAEQPTTQIFSEPAMAQEDALSYLVLGRSRTNNGEDNNMLAEAALGLGLMGSAGVTSDIAHKLGIQDFDLDTQGTGNSTAVVASGKINEKLSLRYGVGVFEPANTIALRYLLSKKVYLEVATGVASSLDIFYKRDF
>CP027725.1|AZE95304.1|3542982_3543456_-|Transcriptional-regulator,-MarR-family
MPHFTPDNFHNCHLGLLLGRAAILKDRIIDTHMEPHGITAAQFKVLIIMAQFGVDTPAELCRHLSLDSGSMTRMLDRLEQKDLLSRKRSELDRRQVQLVLTADGQRLADMLPHIGAQALNQLAGVLETGELETLERILKKILIAAGDPITIQRVGNQ
>CP027725.1|AZE95303.1|3541534_3542986_-|Outer-membrane-factor-(OMF)-lipoprotein-associated-wth-EmrAB-OMF-efflux-system
MNKRALSLVLAAMTLAGCANYSGLDTQGQRLDANALQTGKSLSGVTLSSAAWPSADWWKSLGDPQLDGLIQEALQNSPDMQVADARAHQAEAAAYAANAARMPTLDASAGVSRSRLARDQDPRGQGDAYSTVRNIGASFNYNFDLWGGQRAAWEAALGQARAAEVDQQAARLTLAANVAKAYSDLGQAHIVRDLAVDDLKRTRQMLDLSKRRLSSGIDSEYQYQQTESLEASSQSQLIDAEKQLQSARIALAVLLGKGPDRGNELARPAVLKPAAVAVPSVLPAELLGRRPDLIAARWRVEAASKDIAASKTRFYPNLNLSASAGAESLLGDAMFGSASRFFNIAPTVSLPIFDGGRLRADLDARDADYDLAVAQYNKTLVQALGDIGTTLSQMRDTGRQIQAQQHAADIAQQSYDTGVQRYSSGIGNYLDVLSIEQQLLQAQRQLASLNAAQIDLSIQLMQALGGGFDANNVAATAPATRTE
>CP027725.1|AZE95302.1|3540319_3541519_-|Multidrug-efflux-system-EmrAB-OMF,-membrane-fusion-component-EmrA
MATADNNNATEQPKDNNPRKRKVMLIGLALIVILGVVGVWAWYELYGRFNESTDDAYVNGNVVEITPLVTGTVVSIGADDGDLVHEGQVLVNFDPNDAAVGLQSAQANLARTVRQVRGLYSNVDGMKAQVNAQKADVQTAQDNYNRRKTLAQGGAISQEELSHARDSLTAAKNALTNLEQQLKTTNALVDDTVISSHPDVQAAAAQLRQAYLTNARSTLIAPVTGYVAKRTVQLGQRVQPGTALMAVIPLDQLWIDANFKETQLRDMRIGQPVDIESDIYGSDVKYSGTVDSLGAGTGSAFALLPAQNATGNWIKIVQRVPVRIHINAEELAKHPLRVGLSTVVNVDLHDQSGPVLAQQPPQKASFTTNVYDRQLAEADAMINQLIHDNSVAAPKAAQR
>CP027725.1|AZE95312.1|3555385_3555778_+|putative-transcriptional-regulator-LiuR-of-leucine-degradation-pathway,-MerR-family
MSTTYSISDLARELDITTRAIRFYEEQGLLAPERRGQERIYSARDKVSLKLILRGKRIGFSLAECRELIELYDPTSGNHIQLNSMLAKIAERREQLEQQLLDIEQMKLELDTAEERCTQALAHTMRQAGH
>CP027725.1|AZE95313.1|3555794_3556694_+|Hydroxymethylglutaryl-CoA-lyase
MSLPSHVRLVEVGPRDGLQNEAQPISVADKVRLVDALSAAGLGYIEVGSFVSPKWVPQMAGSAEVFAQIQRKPGVTYGALAPNLRGFEDALAAGVKEVAVFAAASEAFSQRNINCSISESLERFAPIMAAARQHGVSVRGYVSCVLGCPYEGDIAAEQVAAVARELYAMGCYEVSLGDTIGTGTAGATRRLFEVVGAQVPRDKLAGHFHDTYGQAIANIYASLLEGIQVFDSSIAGLGGCPYAKGASGNVATEDVVYLLNGLGIDTGIDLERLIGAGQQISQVVGRASGSRVAKARNLG
>CP027725.1|AZE95314.1|3557233_3558871_-|Acetoacetyl-CoA-synthetase-(leucine)
MDQPNQSYSRGSQDKALLAMTIGEAFDRTAAQYPDGEALVVRHQQRRYTWRELAETVDLHARAFLALGMQTGDRLGIWAPNCAEWLVCQVASAKLGVILVNINPAYRSSELDYVLKQSGCQWLVCAGAFKASDYHAMLQELKPDLRGLISLDPNPPPAFMPWSQLSALGADVPPWQLHSRQASLHFDQPVNIQYTSGTTGFPKGATLSHHNILNNGYMVGESLGLAAQDRLVIPVPLYHCFGMVMGNLGCITHGTTMIYPNDGFDPLLTLTAVAEERASGLYGVPTMFIALLDHPRRAEFDLSSLRTGIMAGSTCPIEVMRRVIGELHMREVQIAYGMTETSPVSLQTGADDDLERRVTTVGRTQPQLENRIIDADGNTVPRGEIGELCTRGYSVMLGYWNNPEGTRDAVDEEGWMHTGDLATMDEHGYVCIVGRNKDMIIRGGENVYPRELEEFFFTHPAVADVQIIGIPDERYGEEIVAWIKFHPGQVASELELQTWCKGRIAHFKMPRHFKFVDAFPMTVTGKIQKFRMREISIEELQTLSQ
>CP027725.1|AZE95315.1|3559029_3560193_+|Isovaleryl-CoA-dehydrogenase
MSYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDIDNLFPADLWRKFGDMGLLGITVPEEYGGAGLGYLAHVVSMEEISRGSASVALSYGAHSNLCVNQINRNGTHAQKLKYLPKLISGEHIGALAMSEPNAGSDVVSMRLRADKRGDVYVLNGSKTWITNGPDANTYVIYAKTDVEKGAHGITAFIVERDWAGFSRSNKFDKLGMRGSNTCELFFDDVEVPEENILGVLNGGVKVLMSGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACERGETTRKDAAGVILYSAERATQMALDAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR
>CP027725.1|AZE95316.1|3560204_3561812_+|Methylcrotonyl-CoA-carboxylase-carboxyl-transferase-subunit
MATLHTQLNPRSTEFVANSAAMRQQVDALHALLAQVQQGGGAKAQERHTSRGKLLPRERINRLLDPGSPFLELSQLAAHQVYGEDVPAAGVIAGIGRVEGVECMIVANDATVKGGSYYPLTVKKHLRAQTIAEQNRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAQGIPQIAVVMGSCTAGGAYVPAMADEAIMVRQQATIFLAGPPLVKAATGEVVSAEDLGGADVHCRISGVADHYADNDEHALALARRSVANLNWRKLGELRQRPPVAPLYSGEELYGVIPADAKQPFDVREVIARLVDASVFDEFKALFGTTLVCGFAHLHGYPVAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACAKVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVKREQAERAGNAFSAEEEAAIKQPILDQYETQGHPYYSSARLWDDGVIDPLQTRDVLALALSAALNAPIEPSRFGVFRM
>CP027725.1|AZE95317.1|3561945_3562752_+|Methylglutaconyl-CoA-hydratase
MSDFNTLELITDSRGFATLWLSREAKHNAFNAQMIRELIIALDHVQGDPSLRFLVVRGRGKHFSAGADLAWMQQSAELDYHTNLDDARELAELMYNLAKLKIPTLAVVQGAAYGGALGLISCCDMAIGADDAQFCLSEVRIGLAPAVISPFVVQAIGERAARRYALTAERFDGRRAREIGLLAESYPAETLDQRVDEWIANLLHNSPAAMRSSKDLLREVGNGALTPALRRYCENAIARIRVSAEGQEGLRAFLQKRTPSWQTKEPHP
>CP027725.1|AZE95318.1|3562748_3564674_+|Methylcrotonyl-CoA-carboxylase-biotin-containing-subunit
MSTLTSVLVANRGEIACRVMRTAKAMGLTTVAVHSAIDRDARHSREADIRVDLGGSKATDSYLQIDKLIAAAHASGAQAIHPGYGFLSENAGFARAVEAAGLIFLGPPAAAIDAMGSKSAAKALMETAGVPLVPGYHGEAQDLETFREACARIGYPVLLKATAGGGGKGMKVVEDVSQLAEALASAQREALSSFGNGQMLVEKYLLKPRHVEIQVFADQHGNCLYLNERDCSIQRRHQKVVEEAPAPGLSAEQRKAMGEAAVRAAQAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEAITGLDLVAWQIRVAQGDVLPITQAQVPLRGHAIEVRLYAEDPANDFLPATGRLALYRESRPGPGRRVDSGVEQGDSVSPFYDPMLGKLIAWGEDREQARLRLLSMLDECAVGGLKTNLGFLRRIIGHPAFAAAELDTGFIPRYQAELLPVAGALSDEFWQAAGSAFMQTLPIGDGPWAATHGFRAGLPALVSLHLSCNGQDRLVTLAGQSSPLTDEQLIIEHQGIRRAHLAVRTEGTVYLRWDGEMQAVSLFDPIAAAEAGHSPQGGLTAPMNGSIVRVLVDIGQRVEAGAQLVVLEAMKMEHSIRAPEAGVVKALFCQEGEMVAEGSALVELEPAH
>CP027725.1|AZE95319.1|3564670_3565363_-|cI
MDYYKLFIALENTQRIVSAMDNWIALVRTNMKDRKVTQDELAERLGMSQGGVGHWLNKRRVPSIADMNRVLAELGLGYLEVALEIRERADTQATLEHHYNPYFRYPVNDWNGVCELREARASYGPERFELTDYHAHGDAFWLPVIGDAMTAPSGLSISAGMLILVDPAVQAQPGKLVVAQWLDNPQATFRQLQADSGQLYLVPLNPTYPKLLFTDDCRILGVVVQATAKF
>CP027725.1|AZE95320.1|3565492_3565786_+|hypothetical-protein
MRCSGAAQRALDYYLKEEMSAPASDTAFFTLKPGISQEEALVHASDLLRSAAATAYESASSHQGNQRDLAFSVVYLIDMAKAMVERSLRTSNAQANG
>CP027725.1|AZE95321.1|3565934_3566150_-|hypothetical-protein
MTPPQLRVYEIDSQALNREDIGLGLAAAFFSQWSFATIRAIKQHTVFISLKPPETTGKKKTRPKSRVKNRD

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Crispr_ID: CP027725_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_8

3880184-3880278

Orphan

Consensus_repeat	Method
TCGGGGGCAAGCCCCCTCCCACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_8

>merge|CP027725|8|3880184-3880278|CRISPRCasFinder
TCGGGGGCAAGCCCCCTCCCACATTTGGACCAAGGTGTATCAGATGGGTAACCGTTGGTTGACAGGCCGCCATCGGGAGCAAGCCCCCTCCCACA

>CP027725|8|8|3880184-3880278|CRISPRCasFinder
TCGGGGGCAAGCCCCCTCCCACA	TTTGGACCAAGGTGTATCAGATGGGTAACCGTTGGTTGACAGGCCGCCA
TCGGGAGCAAGCCCCCTCCCACA

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE95588.1\|3868204_3868933_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE95592.1\|3873523_3874930_-\|gamma-aminobutyrate-(GABA)-permease	unknown	unknown	gnl\|CDD\|273797
CP027725.1\|AZE95595.1\|3878258_3879992_-\|Oligopeptide-transporter,-OPT-family	unknown	unknown	gnl\|CDD\|367370
CP027725.1\|AZE95598.1\|3883332_3884028_-\|tRNA-(adenine(22)-N(1))-methyltransferase	unknown	unknown	gnl\|CDD\|225258
CP027725.1\|AZE95593.1\|3875082_3877647_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE95601.1\|3886457_3887783_+\|Glucarate-dehydratase	unknown	unknown	gnl\|CDD\|211799
CP027725.1\|AZE95600.1\|3885077_3886439_+\|putative-MFS-type-transporter	unknown	unknown	gnl\|CDD\|340877
CP027725.1\|AZE95605.1\|3890909_3892202_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379114
CP027725.1\|AZE95604.1\|3890262_3890598_+\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE95591.1\|3872415_3873501_-\|Transcriptional-regulator,-AraC-family	unknown	unknown	gnl\|CDD\|227311
CP027725.1\|AZE95596.1\|3880319_3880946_-\|Glutathione-S-transferase	unknown	unknown	gnl\|CDD\|198298
CP027725.1\|AZE95594.1\|3877696_3878098_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341118
CP027725.1\|AZE95603.1\|3888958_3889921_+\|Transcriptional-regulator,-AraC-family	unknown	unknown	gnl\|CDD\|181818
CP027725.1\|AZE95590.1\|3870600_3872367_+\|Subtilisin-like-serine-protease	unknown	unknown	gnl\|CDD\|173787
CP027725.1\|AZE95602.1\|3887951_3888833_-\|Beta-lactamase-like	unknown	unknown	gnl\|CDD\|225130
CP027725.1\|AZE95586.1\|3867000_3867414_+\|D-mannonate-oxidoreductase	unknown	unknown	unknown
CP027725.1\|AZE95587.1\|3867830_3868064_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE95597.1\|3881013_3883071_-\|Methyl-accepting-chemotaxis-sensor/transducer-protein	unknown	unknown	gnl\|CDD\|223910
CP027725.1\|AZE95589.1\|3869014_3870484_-\|putative-MFS-type-transporter	unknown	unknown	gnl\|CDD\|340929
CP027725.1\|AZE95599.1\|3884040_3884751_-\|Transcriptional-regulator,-GntR-family	unknown	unknown	gnl\|CDD\|225097

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE95592.1\|3873523_3874930_-\|gamma-aminobutyrate-(GABA)-permease	gnl\|CDD\|273797	TIGR01773, GABA_permease, gamma-aminobutyrate permease. GABA permease (gabP) catalyzes the translocation of 4-aminobutyrate (GABA) across the plasma membrane, with homologues expressed in Gram-negative and Gram-positive organisms. This permease is a highly hydrophobic transmembrane protein consisting of 12 transmembrane domains with hydrophilic N- and C-terminal ends. Induced by nitrogen-limited culture conditions in both Escherichia coli and Bacillus subtilis, gabP is an energy dependent transport system stimulated by membrane potential and has been observed adjacent and distant from other GABA degradation proteins. GabP is highly homologous to amino acid permeases from B. subtilis, E. coli, as well as to other members of the amino acid permease family (pfam00324). A member of the APC (amine-polyamine-choline) transporter superfamily, GABA permease possesses a "consensus amphiphatic region" (CAR) found to be evolutionarily conserved within this transport family. This amphiphatic region is located between helix 8 and cytoplasmic loop 8-9, forming a potential channel domain and suggested to play a significant role in ligand recognition and translocation. Unique to GABA permeases, a conserved cysteine residue (CYS-300, E.coli) located at the beginning of the amphiphatic domain, has been determined to be critical for catalytic specificity. [Transport and binding proteins, Amino acids, peptides and amines].	0
CP027725.1\|AZE95595.1\|3878258_3879992_-\|Oligopeptide-transporter,-OPT-family	gnl\|CDD\|367370	pfam03169, OPT, OPT oligopeptide transporter protein. The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.	1.10198e-92
CP027725.1\|AZE95598.1\|3883332_3884028_-\|tRNA-(adenine(22)-N(1))-methyltransferase	gnl\|CDD\|225258	COG2384, COG2384, Predicted SAM-dependent methyltransferase [General function prediction only].	2.84526e-70
CP027725.1\|AZE95600.1\|3885077_3886439_+\|putative-MFS-type-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.49413e-94
CP027725.1\|AZE95605.1\|3890909_3892202_+\|hypothetical-protein	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	1.13963e-12
CP027725.1\|AZE95590.1\|3870600_3872367_+\|Subtilisin-like-serine-protease	gnl\|CDD\|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	2.31949e-26
CP027725.1\|AZE95596.1\|3880319_3880946_-\|Glutathione-S-transferase	gnl\|CDD\|198298	cd03189, GST_C_GTT1_like, C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain. GTT1, a homodimer, exhibits GST activity with standard substrates and associates with the endoplasmic reticulum. Its expression is induced after diauxic shift and remains high throughout the stationary phase. S. pombe GST-III is implicated in the detoxification of various metals.	4.87175e-41
CP027725.1\|AZE95594.1\|3877696_3878098_-\|hypothetical-protein	gnl\|CDD\|341118	cd17035, T3SC_IB_Spa15-like, Class IB type III secretion system chaperone protein, similar to Shigella flexneri Spa15. This family includes type III secretion system (T3SS) chaperone proteins similar to Shigella flexneri Spa15, Salmonella enterica InvB, and similar proteins. In S. flexineri, which is a facultative intracellular pathogen that invades the colonic epithelium and causes bacillary dysentery, the T3SS allows injection of a number of effectors to ensure their stabilization prior to secretion. Spa15 is the chaperone for several TTS effectors, including IpaA, IpgB1, OspC3, OspB and OspD1. Effector IpgB that chaperone Spa15 is a mimic of the human Ras-like Rho guanosine triphosphatase RhoG, thus activating Rac1 guanosine triphosphatase and setting off membrane ruffling of the cell, assisting the internalization of Shigella. Also, Spa15 is a chaperone for secreted anti-activator OspD1 which is involved in the control of transcription by the type III secretion apparatus (T3SA) activity in Shigella flexneri.	1.68216e-34
CP027725.1\|AZE95603.1\|3888958_3889921_+\|Transcriptional-regulator,-AraC-family	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	1.04168e-110
CP027725.1\|AZE95591.1\|3872415_3873501_-\|Transcriptional-regulator,-AraC-family	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	2.53969e-131
CP027725.1\|AZE95602.1\|3887951_3888833_-\|Beta-lactamase-like	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	3.28068e-17
CP027725.1\|AZE95601.1\|3886457_3887783_+\|Glucarate-dehydratase	gnl\|CDD\|211799	TIGR03247, glucar-dehydr, glucarate dehydratase. Glucarate dehydratase converts D-glucarate (and L-idarate, a stereoisomer) to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase (GenProp0716). The E. coli enzyme has been well-characterized.	0
CP027725.1\|AZE95597.1\|3881013_3883071_-\|Methyl-accepting-chemotaxis-sensor/transducer-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	8.20839e-62
CP027725.1\|AZE95589.1\|3869014_3870484_-\|putative-MFS-type-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.67423e-37
CP027725.1\|AZE95599.1\|3884040_3884751_-\|Transcriptional-regulator,-GntR-family	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	3.53763e-57

>CP027725.1|AZE95595.1|3878258_3879992_-|Oligopeptide-transporter,-OPT-family
MHPTSATTSVERELSLRAVITGILLGILLTPSNVYAGLKIGWSFNMSIIALLIGYAIWQGLAKRSAAPLPWTLHESNINQTVASAAASIISGGLVAPIPAYTLLTGNQLEAIPMIAWVFSVSFLGIWIAWYLRPSLLNDKALKFPEGMATLETLLHIYNHGREAATRLKVLLGAALLSGSVKWLDTFLWAFPRWSPTAQLERLTFTTDPSLLLLGFGGIIGIRVGLTLLLGALLAWGGLGPWLLAHGLVNVAPDSSGPQFAALVEWLLWPGVSLMVCSTLASLAIRLWALHRTTRADGGTPWTLPKPGPAAGFALAIILVVSLQAVLFGINPWMALLTIPLAICLAAVAARVVGATGIPPIGAIGQLSQLSFGIVAPGQVPINLMSANTAGGSAGQCTDLMNDFKVGKAIGATPHKQVIAQILGIFVGSIVGVFAYLALIPDPQTMLLTEQWPAPAVATWKAVAQTLTHGLDSLSPSIRWAIAIAGLLGVVLGVLDSTLPAHRSRYLPSAAALGLAFVLPASISLMMALGAVLTWSVSQRWPSLTERFAITAAAGLIAGESITGVGASLWQMMVQAS
>CP027725.1|AZE95594.1|3877696_3878098_-|hypothetical-protein
MNADIAKTLRETLLDLGVPQEQIGYFDRHASIALNFKTISPIMLTADRHGVWMWSELNNLNSATLNIHAEKLLRLLQHALPSVVTGQPVLGKGLRGYEVKALLDDACMGSAKTLQGALDGFFRLMTSLHSIFK
>CP027725.1|AZE95593.1|3875082_3877647_-|hypothetical-protein
MPITNDNVSSAVAELQANADSRVLKNVEFVKNFDYIKNKPIEVTSNALPTVTLKADGQERPVSFLYGDTQVAQIRNGAIYNAVIDSDIVEKHSQDRIAPGKASIKDGALSLGLNRFRIAGPAETETQKILTRLRGITDPEQRKAELTKLVANGSTQSAEGSMRLKMVNDPVRRAFESYYAKHALQDYFHSPDTYKTFVDISNNQVKYIKDNYVSAPLFEKYEAAWKNQSFDTRIVGLDQLQGFYTRAEKTLETLNISPEARTALFDIYKHRYLSYALKNEPDTEAKLPAGHWDGVFDPIKAPGKGRIELNAREGNLFRQADSHNVGILRNIDATPRDLRLNEPFNIKYENDYQSQLLASASTRCPDRLEMQDPAHPDASKPGSYLKTFFEKGTGTYVNGPSGSIVIEQGAVRACKDVHANTRPDDLETYLAIQALLFIYVDGGHSMDEISYALTHPTVQDKLHQAFSEKPGFEHIGDKLFMNHGALENAAKDAAVFNDVLKAKDAAHQQITHGNPAGQAARTATKALALAQTVAARNVLYKPSDVLTQELAGAASVLHRVVSNLSPQHQNLLGAHLLGEGRLLAGQTTDHLLAALARAGSGAASAIDRAVVIALMGDIGGFYTTPGNADQGLMTALNRQLQAQGLKVPDAAAVQRMREHGGSAAVGPDKRAERTVRAFDSPADMPFRAGVHNSGREADKALNVPASERIPENRWAVFDIGTARIKETTEPLVGHMSASPAEILQAWDMLRGVSANDQYVGALLAQDGSRLTPMSDLTPAEQEQRYARAAGAGALLVGLGYHSAVEVLEGTLVYTGQSIRGEGTLAASQRDSAHVFGHGAATELMSELFKAGTAT
>CP027725.1|AZE95592.1|3873523_3874930_-|gamma-aminobutyrate-(GABA)-permease
MNSLNSNDSNGQLAQGFKPRHVTMLSIAGIIGAGLFVGSGHAIAAAGPAVLLAYLFSGLLVVLVMRMLGEMAVARPDTGSFSTYADQAIGRWAGFTIGWLYWWFWVLVIPIEALAAGHVLNQWFPQVDAWLFALLSIILLVITNLFSVAKYGEFEFWFAMAKVIAIIGFIGLGFSVLMGWMPDHQASGLSRLMEENGGFAPNGLSAVVGAFITIMFSFIGTEAVTIAAAESSNPAQNIARATRSVIWRIGVFYLLSIFVVISVVPWNDPLLASVGSYQRALELMNIPNAKFMVDVVVLIAVASCMNSSIYISSRMLFSLGKRGDAPPALKRTSAAGVPRAAVIASTIIGAGVTLLSYFMPAGLFQFLLASSGAIALLVYLVIAISQLRMRRLLVRQNVELVFRMWLFPWLTYLVIVFICAALAVMMVTPEHRTEVSSTIGLALVISLIGVVTARQHGQSAKAVVVEPS
>CP027725.1|AZE95591.1|3872415_3873501_-|Transcriptional-regulator,-AraC-family
MEADAPACKTLGFLLLDQFTLISLSCAVEPLRIANQLAGEELYRWRTLSLNGEPVWASDGVSVTPDAVAHEQRDLDAVIVCGGVGIQQAATPAHLTWLRNQARLYCNRLGAVCTGSWALAKAGLLDGFQCSVHWELMASLQEAFPRVTVSASVFCLDGNRFTSSGGTAPLDMMLHLIGRDHGHELAAAISQMFVYERIRNERDTQRVPLKHLLGTQQPKLQEVVALMEANLEEPIDLDQLAAYVQVSRRQLERMFQRYLYCTPSRYYLKLRLTRARQLLMQTPISMVELAAICGFVSTPHFSKCYRDFFGVAPSDERSDMRLRLPITPRPVARPGAPAKPRNILEQAREESTFASVKIQRR
>CP027725.1|AZE95590.1|3870600_3872367_+|Subtilisin-like-serine-protease
MPLNPAAFAMLLTLAAGTALASQEPLRLEQLKRCGDLLENQQQDWCLRVRGLGDATAHLKLGGKVLPQDAVQRDGDQLRLRLDSRRYQSGPLWLEDGPRTSNAAWLSLRDSQVVAAGPGEVAKNMDGLTTYVDLVSVLIEEDQDGRQEAERLARKYGAKVVGSIAPLNVFQLRLPATDLIQRDALVLRLGSETSVDAVVIEESAAEEAEQAAPRREAPKKPSPDSDEWAANRFLDAVAYYQRRIPGQRSPIVAQPVRIGVIERGVDFDTADFADYLGACAPRRTCVYAGDTGSADSHGTTVAGILAAGWNNGGNTGFLRGLDKAGGGFDVIVERNSDAGITANIAASVNLVEDGVRVLNWSWGIHRVGTKDVNGQDVDSLVRSGIAMSGYEELLEEFFLWLRKEHPDVIVVNSAGNGSAFSGSDEYRLPSSFITEQLLVVGGHQRNERDGVAIDDPAYAVTRSSSNVDMRVDITAAACAHASTPGADQEGAVHCGTSYATPMVAGLLAAMLSINPQLQPEQLRTLLRRSALAIGDNHDFERSDAQDLTAPILPSERNYQLNDKDVGRSARLDMQKALDLAVQSRTRVR
>CP027725.1|AZE95589.1|3869014_3870484_-|putative-MFS-type-transporter
MTDVTMTQPHSNTPGALFETDLPARLDRLPWGRFHTLLVFALGITWLLDGLEVTLAGSVSGALKSSTGLNFSNVDIGLAGGVYIAGAVLGALLFGWLTDRLGRRKLFFITLWLYVGATAATAFSFNLESFLLFRFLTGMGIGGEYTAINSTIQEFTPARYRGWVDLTINGTFWLGAALGAGGAIVLLDPQIVGGDLGWRLCFGIGAALGLLILVMRLWLPESPRWLLIHGRHAEAQRIVDGIEARLCEQGHALAPVTSPPLRLHARDHTPLAEIFHTLFVSFRRRALVGMTLLTAQAFFYNAIFFTYALVLTDFYQVPAERVGWYVLPLALGNFCGPLLLGRLFDVIGRRVMISFTYATSGVLLALSGYAFQLGWFDVTQQAIAWMVIFFFASAAASSAYLTVAETFPLEIRALAIAVFYAFGTGLGGIIGPTLFGELIQTQQRGSLLIGYLIGATLMLVAAVVQAIWGVAAERKALERVARPLSQAVE
>CP027725.1|AZE95588.1|3868204_3868933_-|hypothetical-protein
MSFSVSAAHIAPANTRLALSEQTLTPQAPPEAASQALANAGPAAVYHPSEAAQTLREPLQVTDTWVGRSESPEYPRFVERFHGAQAVLKSVFTAFESTLASTAPDLAGADYGFTVEADGRLKVLDKAGQLSEANIKRLTDLLNGSADLKTAAVAYRNATIDMTDASSPWSGSVMGYYSLTNENFANSIDLAPLLRTYDPSDLTDIKDRFLVTQLAYKGERATEETERAMFERRGGQGVNVQV
>CP027725.1|AZE95587.1|3867830_3868064_-|hypothetical-protein
MSIDQISLPKGVGPHAAKLLDAITGASTHEELNRAGGKAEGFVLGLESTKAIKSQIAESLYVAYDDAASNRAGELKG
>CP027725.1|AZE95586.1|3867000_3867414_+|D-mannonate-oxidoreductase
MKLKVVLLSSILLVSPLYQAYADSCNKNIFDGYDCKYDDGTTSSSRANIFGGQDTRYSDGRTSESSANIFGGQDTRNSNGTTSQSNANIFDGQDTRNSDGTTSRSNANIFGGQDTRYSDGRTSKSRANIFGGQDTEN
>CP027725.1|AZE95596.1|3880319_3880946_-|Glutathione-S-transferase
MITVHHLNNSRSQRILWLLEELGLPYQIKRYQRDPKTNLAPAELKAIHPLGKSPVIEDGSRVLIESAAIIDYLIRHHGNGRLQPDPASASYDQYVQWLHFAEGSAMLPLMLNLYVGRLGEAGAPLHPRIESELANYLGYLNGVLGQTPYLVGDELTGADIQMSFIGEIAKAQGKLQAYPNLAAWVDKLQQRPAYRKAVEQGGEYAFAK
>CP027725.1|AZE95597.1|3881013_3883071_-|Methyl-accepting-chemotaxis-sensor/transducer-protein
MQRLLSPGIRLLGRFGFARKFQVLFLLFMLPLAGSLWMIGQDYHDKLAVITSEQSGVRQLLALDPLDAQLSAQRNLAARWKALDILHTPTPAAQAAMARVDAGSPLIQQGLQTLGDTLKTHNASAATQARFDTLQAAVRGMDTQALRTVGWWPDGYDRFTAALTAMQSLREQITLDAGLILDPWLETYLLMQISSQHTPDLIERIGRTASVGQSSIASGQFTLQSRLQMRDLRGRIGDARDQLVKAATALKAKQYPGLEPWTEQYDASLQRLDSELKTLDDGVFGGTIKLDTAAFDQSVDAMLAALGALRSQSLDSLDARLDYYRERSLQHFIPVAATFSLLALAALYLFICLQASIRRSASGITTLAESLRDGNLHVEVAVQGRDELAAISTALNVAVVQLRTSLLGVNHETQQLGATVLTLSAQSGSTLTDVEDQRHQISQIAAAATQLAATSLGVAKSCEQAADSAQHTRRIAEDSSRDSQRTTASIQQLNQRLTDTANALEQVSQQGQQIQSVVDTIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLSQRTQASTAQIAGTVDSLRATVSQAVSLMGAACEQALSDAESVTGLGARLGEIAGAVQHVTDTLAHIAAAVEEQAATADEVSGNIQQVDQAAGRLLDGARAVNQAADSLSQGSRALSDNTARFRLG
>CP027725.1|AZE95598.1|3883332_3884028_-|tRNA-(adenine(22)-N(1))-methyltransferase
MNPQTLSLRLERVAAQVPAGARLADIGSDHGYLPVALMRRGAIAGAVAGEAATTPFQAARRTVRDHGLEAHISVRLADGLAALEPGDAITAISLCGMGGETIRDILDRGKAQLSGQERLILQPNGGEYPLRHWLMGNGYRIVHEELLHENRFFYEIIVAERTGPVSYTEEQLYFGPLHLLERRPAFVAKWQRLLREKQKTRVSFAKARQSVPAEKIHEIHRHIQWITQLLT
>CP027725.1|AZE95599.1|3884040_3884751_-|Transcriptional-regulator,-GntR-family
MPIENAPPVRRRSTNLAQGVVDALTRRILLGQLKPGEKLPSESTIVLEHGVSRTVVREAISKLQASGLVETRHGIGTFVLAQHARQGLRLHVDTVASVRNMLELRLGLEVQAVALAALRRTDAQLAHMRQALDDYQASLANNDSCVEEDKRFHQLIAEATGNTFFSEIMQHLGTAMIPRTQVKADERGGADFAQLGQLASLEHEAIFNALKRQDPDAARAAMVLHLTNSRDRFSGE
>CP027725.1|AZE95600.1|3885077_3886439_+|putative-MFS-type-transporter
MDNSSHASAASQTDSVLTRAVSKVKGHVLPLFVIMFILNYIDRVNIGFVRTHMEHDLGIGAAAYGFGAGLFFIGYAIFEVPSNMLLQKVGARIWLTRIMFTWGIVATLMAFIQNETHFYILRFLLGVAEAGFFPGVIYYFTRWLPGVERGKAIAIFLSGSAVASLISGPLSGALLQIEGFGLHGWQWMFAIEGLASVALGFFVWFWLDSKPHDAKWLSREEQDALVAAIDQEQRDREALTTVKPTLGKLLRDRQILLFCVLYFCIQLTIYAATFWLPSIIKKMGDLSDIQVGFFNSIPWLISIIAMYAFATLSGKFKFQQAWVAAALLIAAAGMFMSTTGGPIFAFVAICFAAIGFKSASSLFWPIPQGYLDVRIAAAVIALINSIGNLGGFVAPTTFGFLEQTTGSIQGGLYGLAGTSVLAAILVFFARTSPAAGLMSPGIAPTANAISKPL
>CP027725.1|AZE95601.1|3886457_3887783_+|Glucarate-dehydratase
MNTPVITHLHVIPVAGHDSMLLNLSGAHGPYFTRNIVIIKDSSGNTGVGEVPGGERIRETLEDARSLVIGQPIGQYQRILNQMRSTFASRDAGGRGLQTFDLRITIHAVTAIEAALLDLLGQFLEVPVAALLGEGQQRDAVKMLGYLFYVGDRTATDLAYRNEAESDDDWLRLRHEKALTADAVVRLAEAAKARYGFNDFKLKGGVLSGDAEIEAVTALAERFPDARITLDPNGAWSLKEAIRLCRDQHHVLAYAEDPCGAENGYSGREVMAEFRRATGLKTATNMIATDWREMGHAIQLQSVDIPLADPHFWTMQGSVRVAQMCHEWGLTWGSHSNNHFDISLAMFTQVAAAAPGEITAIDTHWIWQDGQRLTRQPLKIEGGYVKVPAKPGLGVDIDMDAVAKAHELYKGMGLGARDDSVAMQFLMPGWRFNNKQPCLVR
>CP027725.1|AZE95602.1|3887951_3888833_-|Beta-lactamase-like
MKFTTLPLTLGIVCGAAAVPAFAGSSTPEAAHKVHLQQVRNATVKITYGGTTFLIDPMLAKKGTYPGFENTYRSELRNPLVELTESPAEVISGVDAVIVTHTHLDHWDDAAQQALPKDIPLFAQHEEDAQLIRSQGFKNVRVLTDEAQFGGVKITRTGGQHGTDEMYAVPALAKPLGEAMGVVFQAPGYKTLYLAGDTVWRKEVDQAIETFHPEVIVLNAGKAMMAGYKGSIIMGEEDVLRAAQTAKNAKIVAVHMDAINHMSLTREALRSYVKQHGIEGRVDIPEDGASLAF
>CP027725.1|AZE95603.1|3888958_3889921_+|Transcriptional-regulator,-AraC-family
MPPIRVAVLAFDGVSLFHLSVPGMVLGTAQSRPDEPHYQVDYCAQVPGMISSDQGLELSVSLGLELMHTADVIIIPAWGDQSVTASPTLINALQLADAQGKLIVGLCLGAFVLGDAGLLDNKEATTHWAARDEFARRFPDARFRPEVLYVCDGNIITSAGTVAAIDCCLHLVRQRLGADVANRTAKMLVTPPHRQGGQAQYVEHPVPQLSRETHLSQVLAWARAHLAEDLSLDVLADRARMSRRTFTRRFKEATGTTVSKWLSAERVARAQALLETTDLAVECIAGEVGFGTALSLRQHFGRQLGTSPSEYRKMFCLGLE
>CP027725.1|AZE95604.1|3890262_3890598_+|hypothetical-protein
MYKVTPNPPNDPDLKLNQAAHRAIDHYLNTGAEPPAPPSSTLFCVAEDASSETLIANSYETFTSVTALLLDLSDELTGKQRDVALAIHQLSELGVLLVDKLMEREGAQADN
>CP027725.1|AZE95605.1|3890909_3892202_+|hypothetical-protein
MLKKLDLKGVGPAPEMNLEFSSRLNFLTGDNGLGKSFVLDTAWWVLTRTWARNIKAVPSEQASKPSIGFSYTKASAGDVTDSSIFVRRTQTWGLKQGRPTIPGIVIYAGVDGSFSVWDPARNYWKNDDEGGSERPKSFDFTPEQVWKGLVGPNGVTHCVGLVRDWVLWQRGRQPAFDDLVRVLEVLSPCEAERLVPGEPTQIGDDVEEVPSLKMPYGQEVPLPLASAGMRRICALAYLLVWTWREHTKASKKYRVKPAREIVFLIDEIECHLHPQWQRRIVPALLSVMSELTQSEKIPIQLLAATHSPLVLASVEPLYETGKDCILDFDLVENHVEVRNLPFTRKGDVNGWLASDIFNLKEPRSVEAEIALTAAYTLLRNLNNAIHEKKLTLNDKAAIRATDKALRESLSDVDRFWVRWSSFRDSLLEKQ

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Crispr_ID: CP027725_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_9

4647838-4647942

Orphan

Consensus_repeat	Method
CTGAGGCCGCCATCGGGGGCAAGCCCCCTCCCACA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP027725_9

>merge|CP027725|9|4647838-4647942|CRISPRCasFinder
CTGAGGCCGCCATCGGGGGCAAGCCCCCTCCCACATTTGGGCCAGGATCGACACAAAATCCTGGTCGGTTCTGAGGCCGCCATCGGGAGCAAGCCCCCTCCCACA

>CP027725|9|9|4647838-4647942|CRISPRCasFinder
CTGAGGCCGCCATCGGGGGCAAGCCCCCTCCCACA	TTTGGGCCAGGATCGACACAAAATCCTGGTCGGTT
CTGAGGCCGCCATCGGGAGCAAGCCCCCTCCCACA

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE96310.1\|4645395_4645770_-\|putative-lipoprotein	unknown	unknown	unknown
CP027725.1\|AZE96309.1\|4644832_4645192_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377796
CP027725.1\|AZE96311.1\|4645943_4647395_+\|Pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
CP027725.1\|AZE96318.1\|4655684_4656317_+\|Flavin-reductase-like,-FMN-binding-domain-protein	unknown	unknown	gnl\|CDD\|224766
CP027725.1\|AZE96302.1\|4636516_4637944_-\|Exodeoxyribonuclease-I	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236979
CP027725.1\|AZE96320.1\|4656638_4656980_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367760
CP027725.1\|AZE96317.1\|4654207_4655533_+\|Alpha-ketoglutarate-permease	unknown	unknown	gnl\|CDD\|340925
CP027725.1\|AZE96308.1\|4643449_4644781_+\|putative-membrane-protein	unknown	unknown	gnl\|CDD\|224635
CP027725.1\|AZE96316.1\|4652611_4653937_+\|C4-dicarboxylate-transport-transcriptional-regulatory-protein	unknown	unknown	gnl\|CDD\|225114
CP027725.1\|AZE96321.1\|4657307_4658237_+\|Transcriptional-regulator,-AraC-family	unknown	unknown	gnl\|CDD\|377694
CP027725.1\|AZE96305.1\|4639760_4641293_+\|5'-nucleotidase/2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|379261
CP027725.1\|AZE96313.1\|4648884_4649061_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE96307.1\|4642443_4643442_+\|MoxR-protein	unknown	unknown	gnl\|CDD\|223786
CP027725.1\|AZE96314.1\|4649106_4650630_+\|Fumarate-hydratase-class-I,-aerobic	unknown	unknown	gnl\|CDD\|224862
CP027725.1\|AZE96306.1\|4641289_4642447_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379527
CP027725.1\|AZE96319.1\|4656363_4656597_-\|hypothetical-protein	unknown	unknown	unknown
CP027725.1\|AZE96303.1\|4638110_4638803_+\|Integral-membrane-protein	unknown	unknown	gnl\|CDD\|377640
CP027725.1\|AZE96304.1\|4638799_4639774_+\|putative-membrane-protein	unknown	unknown	gnl\|CDD\|224219
CP027725.1\|AZE96312.1\|4647959_4648892_-\|2-polyprenylphenol-hydroxylase-like	unknown	unknown	gnl\|CDD\|235575
CP027725.1\|AZE96315.1\|4650851_4652618_+\|C4-dicarboxylate-transport-sensor-protein-dctB	unknown	unknown	gnl\|CDD\|226654

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE96309.1\|4644832_4645192_-\|hypothetical-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	0.000117261
CP027725.1\|AZE96311.1\|4645943_4647395_+\|Pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
CP027725.1\|AZE96318.1\|4655684_4656317_+\|Flavin-reductase-like,-FMN-binding-domain-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	1.91529e-40
CP027725.1\|AZE96302.1\|4636516_4637944_-\|Exodeoxyribonuclease-I	gnl\|CDD\|236979	PRK11779, sbcB, exonuclease I; Provisional.	0
CP027725.1\|AZE96320.1\|4656638_4656980_-\|hypothetical-protein	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	1.20262e-11
CP027725.1\|AZE96317.1\|4654207_4655533_+\|Alpha-ketoglutarate-permease	gnl\|CDD\|340925	cd17367, MFS_KgtP, Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters. This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0
CP027725.1\|AZE96308.1\|4643449_4644781_+\|putative-membrane-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	5.36454e-71
CP027725.1\|AZE96316.1\|4652611_4653937_+\|C4-dicarboxylate-transport-transcriptional-regulatory-protein	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
CP027725.1\|AZE96321.1\|4657307_4658237_+\|Transcriptional-regulator,-AraC-family	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	1.49631e-57
CP027725.1\|AZE96305.1\|4639760_4641293_+\|5'-nucleotidase/2',3'-cyclic-phosphodiesterase	gnl\|CDD\|379261	pfam13559, DUF4129, Domain of unknown function (DUF4129). This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	0.000671409
CP027725.1\|AZE96307.1\|4642443_4643442_+\|MoxR-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.95799e-97
CP027725.1\|AZE96314.1\|4649106_4650630_+\|Fumarate-hydratase-class-I,-aerobic	gnl\|CDD\|224862	COG1951, TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion].	8.16493e-145
CP027725.1\|AZE96306.1\|4641289_4642447_+\|hypothetical-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	3.01945e-08
CP027725.1\|AZE96303.1\|4638110_4638803_+\|Integral-membrane-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.34337e-17
CP027725.1\|AZE96304.1\|4638799_4639774_+\|putative-membrane-protein	gnl\|CDD\|224219	COG1300, SpoIIM, Uncharacterized membrane protein [Function unknown].	6.14763e-46
CP027725.1\|AZE96312.1\|4647959_4648892_-\|2-polyprenylphenol-hydroxylase-like	gnl\|CDD\|235575	PRK05713, PRK05713, iron-sulfur-binding ferredoxin reductase.	0
CP027725.1\|AZE96315.1\|4650851_4652618_+\|C4-dicarboxylate-transport-sensor-protein-dctB	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	0

>CP027725.1|AZE96311.1|4645943_4647395_+|Pyruvate-kinase
MSVRRTKIVATLGPASNSPEVLEQLILAGLDVARLNFSHGTPDEHKARAKLVRDLAAKHGRFVALLGDLQGPKIRIAKFTNKRIELKIGDKFTFSTSHPLTDGTQEVVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTATPTELHCTVIIGGPLSDHKGINRRGGGLTAPALTEKDKADIKLAAEMEVDYLAVSFPRDAADMEYARKLRDEAGGTAWLVAKIERAEAVADDETLDGLIKASDAVMVARGDLGVEIGDAELIGIQKKIILHARRHNKAVIVATQMMESMIQNPMPTRAEVSDVANAVLDYTDAVMLSAESAAGPYPLEAVQAMARICVGAEKHPTSKTSSHRIGKVFESCDQSIALAAMYTANHFPGVKAIIALTESGYTPLIMSRIRSSVPIYAFTPHREAQARAAMFRGVYTIPFDPASLAPNEVSQKAIDELVKRGVVEKGDWVILTKGDSYHTTGGTNGMKILHVGDPQF
>CP027725.1|AZE96310.1|4645395_4645770_-|putative-lipoprotein
MRILLVAALAVSVVGCTRWSMDHHLNNAYRAYGVGDCARVTLELSQVDRESRTRRYVQPEVSMLRGQCLERQKLFVDAAQTYQFIISQYPSSEYAYRARARLDTLRQLGHYSGASVAQPRPASL
>CP027725.1|AZE96309.1|4644832_4645192_-|hypothetical-protein
MFIERRIERHQLPYFLQVFNRLTDKPIGFLGDVSEDGLMLISQLPMMIGADFELRLKIPGPHGEFQAVDLTATCLWSLEDVNPQHYDSGFRVLQACEEYAQLISALLHYFSFDPLQASV
>CP027725.1|AZE96308.1|4643449_4644781_+|putative-membrane-protein
MKPTRLLLTWLGVLLALNILLGASMALQFKVPDTLHSIAWGLLLALLLLAILDAIRLRRRPSARVHRTLPGSLALGRWGEVRLSLEHDFPQPLTVQVFDHVPDGLVVDNLPQSITLRPGERGELGYRVRPVRRGHFSFSRCEIHLPSPLGLWSARRWLDVADATRVYPDFARLSGAQLQGVDNWLSQLGVRQHQRRGPGLEFHQLREFREGDSLRQIDWKATARQRTPIAREYEDERDQQIVFMLDCGRRMRSQDDELSHFDHALDACLLLSYVALRQGDAVGLCTFASDQPRYLAPTKGNGQLNVLLNAVYDLQSTRKTADYEAAASQLLARQKRRALVIVVTNLRDEDDDTLVSAIKRIGRHHRVLIASLREEVLDQLRQAPVQTLPEALAYSGAIDYLNRRNQLHDRLGAHGLSVLDSLPSTLGAALVTRYLRWKKAGVF
>CP027725.1|AZE96307.1|4642443_4643442_+|MoxR-protein
MSDSPMATTLNAENTIQTASQQAQALRVELRKAVIGQDAVIDDVLTALIAGGHVLLEGVPGLGKTLLVRALARCFGGDFARIQFTPDLMPSDVTGHAVYDLQTEQFKLRKGPLFTHLLLADEINRAPAKTQAALLEAMQERQVTLEGEALPIGAPFMVLATQNPIEQEGTYPLPEAELDRFMLKVRMDYPDARQEVDMVRQVTRSSRADMLDVQPLRTVLQAEDVVQMQQIASGMPLDEQVLDYAVRLARATRSWPGLTIGAGPRASIALIRGARARALLRGGEFVTPDDVKGCALAVLRHRVRLAPELDIDGLEVDQVLKQLLDQIAAPRQ
>CP027725.1|AZE96306.1|4641289_4642447_+|hypothetical-protein
MNRPLLWIAALLACVLGAGGLYAWHKAIPYEEVVDRGPSPEALANPYLAAEHFLRQQGLAVAHANGLERLADLPAPGHSLLLLGERGNMTPRQVEQLLAWAEAGGHLLLVAEALWDDETGKSGDLLLDRLNLRQTLSDDLDEPAPPRKKSAPDLTKLYVDNETAPAYFSFDTDFNLTDPGHLAQFSANSAKSSHLMQRDLGQGRVTVITDSDLWKTPGIGKHDNAWLLWYLNQGTDVTLLFNSDTDDLLTLLVRYFPQALVALAALVALALWHAGMRQGPIQAPASKARRQLQEHLRASADFLLRRSGQRTLLQALQHDLLRAARRRHPGFEHLDTAEQWQVLEHLTRQPSPIIRQALGAPALKRLSNADFSRQVACLQTLRNAL
>CP027725.1|AZE96305.1|4639760_4641293_+|5'-nucleotidase/2',3'-cyclic-phosphodiesterase
MRLTDASVVIRPRTSWEAMDLGVLMARKHRVLLMSSWALVSLPVFMLLTALLWQYPSYALFLFWWLKPAFERLPLYILSKALFGETPSLKQAARQWPRLLKGQLFASLTWRRLSLSRSFLLPVSQLEGLDGPVRQQRLGVLQQRNAGAARWLTIIGVHLEIGLWFGCMALFYLFIPEQVELDWDWQRLVLATGPQGLWLEHLSNAFYALVLVFWEPIYVACGFSLYLNRRTVLEAWDLELVFRRLRQRLGSVVPLLLLLAASLTLVQLSPSALADQTADPKPLSTQAASQSIKALLEKPPFKNPETVTRYRFGEEKPATARKVHGDGKLPGWLQQLLDNLNSNTFKYVAQGLEVLLWSLVIGGLALVVWRYREWLRTFVSRRRRPQARIARPAPAQLFGLELGVETLPDDIASVAEQLWPTQPREALGLLYRGLLSRLLHEFNLPLKSADTEGQVLERVHHLQQPQLLAFSRELTGHWQNLAYGHRLPPGAAQQKLCSDWRALFSSGASQ
>CP027725.1|AZE96304.1|4638799_4639774_+|putative-membrane-protein
MKQNLFESRHQPQWQAFAEQLDQLERGKAIDVADFPYHYRRLCQHLALAQARGYSSYLVDRLQQLALRGHQQLYRHRSQTTASALAFILADFPRLVREQWRFVLIASLLFFGSLLGIAVLVYLFPDLIYSIVSPQQVAEMHSMYDPAASRLGRAAERASSEDWMMFGYYVMHNIGIAFQTFAAGLLFGLGSVFFLVFNGLIIGAVSGHLSEIGYGQTFWSFVIGHGAFELSAIALAGAAGLQLGWSLIAPGRLARSESLRLAARKSVQMLCGVMVFLLIAAFIEAYWSSTTTIAPWIKYLVGSALWLLVAAYLIFAGRTRHAPD
>CP027725.1|AZE96303.1|4638110_4638803_+|Integral-membrane-protein
MPTAPLDTCYQIETPEGIDLPLRPAGLAPRALAYAFDLLARGVIMGLLLVPLALLGNLGLGLGSLLLFLVSWWYMVLFEVLNQGCSPGKQVMGLRVVQDDGTAIGWSASLIRNLLRFVDMLPFGYSFGAISCLQHPHFKRLGDLAAGTLVVYREQSLARPPLPQAAALRLPFALELSEQWAILGFAERQADLSAERAHELAAILAAPLQVPAARAVEQLNGVARGLLGPT
>CP027725.1|AZE96302.1|4636516_4637944_-|Exodeoxyribonuclease-I
MTSIFWYDYETTGINPRSDRPLQVAGIRTDLELNEVGPPINLYCQPSDDILPHPAACAITGITPQVLAQQGLAEADFMTRVHAELAAPGTCGAGYNTLRFDDEMTRYSLYRNFFDPYAREWQGGNSRWDLIDVMRTAYALRPEGIVWPEQDGRVTLKLERLTQANGIDHGQAHDALSDVRATIGLARLVREKQPRLYEWLFQLRSKQRVMDQVRLLQPLVHISGRFSAERHYLGVVLPLAWHPRNRNALIVCDLGLDPQALLELDAETLRERLYTRRDALAEGELPVPLKLLHINRCPVVAPLKVLRAQDRERLQLDMEVCQARALRLTDAQEVWRDKLASIYAEEEYAPNADPEQQLYEGFIGDRDRRLCEQVRLAEPAQLGRQQWPFDDHRLPELLFRYRARNFPETLNNEEQERWRLFCQQRLSDPVWGAPNTLEAFKLAHKELENSATSFQCQVLGEWQDYADSLAARLNL
>CP027725.1|AZE96312.1|4647959_4648892_-|2-polyprenylphenol-hydroxylase-like
MPELHVGERHWSVATGSNLLDALNQAGVAVPYSCRAGSCHACLVRCRGEVQDRRPEALSPAQRQDGWRLACQCQVVGDLRVEAFDPMRDGLAAQVVGADWLTSTVLRLRLQPERGLRYRAGQHLVLWAGQVARPYSLASLPQEDPYLEFHLDCRLPGEFSNAARQLNIGDRLRLGELRGGALHYDPDWHARPLWLLASGTGLGPLWGVLREALRQDHQGAIRVIHLAHDAEGHYLAGPLAALAASHSSLTVELWTGAQLDQALAQLRLVSRQTLALVCGHPDSVEAFSKRLFLAGLPRNQLLADVFVPRG
>CP027725.1|AZE96313.1|4648884_4649061_-|hypothetical-protein
MLHRSAEATFHRHAIGAGATLKRRGSITRGGGRYTRLWSNCRRHDSLCASLLIEPLYA
>CP027725.1|AZE96314.1|4649106_4650630_+|Fumarate-hydratase-class-I,-aerobic
MTVIKQDDLIQSVADALQFISYYHPVDFIQAMHEAYLREESPAARDSIAQILINSRMCATGHRPICQDTGIVTVFVRVGMDVRWDGATMGLDDMINEGVRRAYNLPENVLRASILADPAGARKNTKDNTPAVIHYSIVPGNTVEVDVAAKGGGSENKSKMAMLNPSDSIVDWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAAVMAKEVLMESIDIHELKQRGPQNRIEEMRLELFEKVNQLGIGAQGLGGLTTVLDVKIMDYPTHAASLPVCMIPNCAATRHAHFVLDGSGPASLEAPPLDAYPEIVWEAGPSARRVNLDTLTPEDVQSWKPGETVLLNGKMLTGRDAAHKRMVEMLNKGETLPVDLKGRFIYYVGPVDPVREEVVGPAGPTTATRMDKFTRQILEQTGLLGMIGKSERGPTAIEAIKDHKAVYLMAVGGAAYLVAQAIKQSRVVAFAELGMEAIYEFDVKDMPVTVAVDSNGESVHITGPAIWQKKISESLAVEVQ
>CP027725.1|AZE96315.1|4650851_4652618_+|C4-dicarboxylate-transport-sensor-protein-dctB
MIAIPRPLRLTFYSLLIIAGAVLAAALATRHAERQALVDDAARANQQLTLYGNSLHTLIERYRALPAVLALDSEMINALKGPLDASTQDLLNRKLERINSAAQSSTLELMDRTGLAVAASNWKLPSSYVGHNYAFRPYFSQTLSQGTGRFYAVGVTTGIPGYFLSSAVVDEREQFLGAMVVKLEFPELEREWAQGNDLLLVSDARGIVFIANQPGWRYRNLRPLSASDLTELKATRQYDKKQLQPLETRTLQRFNDNSHLMRVNGPDGSANYIWESLPLKAEGWTLHLLRKPQFPFEDQRNAGLAAAGSWLALVFLVLFLSQRWRLARLRQRSREELEQLVEERTQALRTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDHGRVDDAYKAITPLDDMLTRMAALTGHLKTFARKSPSGLRERLDLTTVVDQSLHLLDARLRDEHIDVALDLTRPAWVRGDAIRLEQVLINLLRNALDAMVDKPRKRLEIRLHADQQLWQLSVSDSGGGIAEEHLNNVFDPFFTTKPVGDGLGLGLAVSYAIVHELGGRLIAGNRGDGAVFTLTLPVALETPDLC
>CP027725.1|AZE96316.1|4652611_4653937_+|C4-dicarboxylate-transport-transcriptional-regulatory-protein
MLNAVIVVDDEASIRTAVEQWLSLSGFAVQLFSRAEECLAQLPRDFPGVILSDVRMPGLSGLELLAEVQRRDADLPVILLTGHGDVPMAVDAMRDGAYDFLEKPFSPDALLNGLRRALDKRGLVLENRRLHQQADHRAHLESSLLGVSRSLQNLRRQVLDLATLPVNVLIRGETGSGKELVARCLHDFGPRAKKPFVALNCAAIPEQLFEAELFGHESGAFTGAQGKRIGKLEYAHGGTLFLDEIESMPLAQQVKLLRVLQEQKLERLGSNQSINVDLRIIAATKPDLLEEARAGRFREDLAYRLNVAQLRLPPLRERREDIPLLYEHFAQSAAERLGRPIEPLSGPQLGRLLSHDWPGNVRELANVAERQVLGLGEPEPEGVEAGQSLAAQQEAFEAHCLKAALTRHKGDIKAVLAELQLPRRTLNEKMQRHGLVREMFL
>CP027725.1|AZE96317.1|4654207_4655533_+|Alpha-ketoglutarate-permease
MDNSNTLPLGSGSAAAPAKERTTSSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKTFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPSYELIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALGVLIVLQQTLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKESAMRTLMRHPKELLTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPLVGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQTWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIAVSLLVYVTMKDTRKHSRITTD
>CP027725.1|AZE96318.1|4655684_4656317_+|Flavin-reductase-like,-FMN-binding-domain-protein
MSDDIHFYEPANGHGLPHDPFNAIVGPRPIGWISSHDREGRLNLAPYSFFNAFNYIPPIIGFSSVGRKDSLNNIEQTGEFVWNLATRPLAEQMNQSCAAVSPHVNEFELAGLTPVASKIVGVPRVGESPVSFECKVTQIIQLQRADKELVPSWLVLGEVVAVHIAKWLLKDGIYDTAAAEPILRGGGPADYFQLGPEALFKMYRPGATKP
>CP027725.1|AZE96319.1|4656363_4656597_-|hypothetical-protein
MARKQFVHHEAVSAVVPGESGYSAAVAVKALDGMGALKFHTILEGQTFKTASDADDAAAAQLECLVDVDAEGQLIWD
>CP027725.1|AZE96320.1|4656638_4656980_-|hypothetical-protein
MSTPIPASHMAFIRARTGCSTELGARLSSLIEPGRQAQGCLQFSLQHSQSDPDVWLISGFWSSEQAMSAYFNSPALMIFTELLNDMVVRSMDFQTFTDASAVQAYGEYLQLAG
>CP027725.1|AZE96321.1|4657307_4658237_+|Transcriptional-regulator,-AraC-family
MSSPDLKPTPLDTEMEKQRAELASIVHRHTWEDGSYGTAITSLYLNRHNTPRDFMPVLVEPALCILASGSKEVRLADEIFAYDPLNYLVFSVAMPVAGRIIDATPQDPNLSVRINIDPAQLTALIAEAGPMGVPSRPTSRGMYVDRIDNQLLDAVLRLTRLLDTPKDIAMLAPLINREILYRLLRGPQGYRLYEIAVANSQSHRVSQAITWLNRNYEQPLRIDDLAREVNLSVSTLHHRFKAITAMSPLQYQKQLRLQEARRLMIAEGLEASAAGYRVGYESPSQFSREYSRLFGAPPLRDLARLRQSI

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Crispr_ID: CP027725_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027725_10

5232924-5233021

Orphan

Consensus_repeat	Method
ATCGGGAGCAAGCCCCCTCCCACATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027725_10

>merge|CP027725|10|5232924-5233021|CRISPRCasFinder
ATCGGGAGCAAGCCCCCTCCCACATTTGGACCGGGATCGACACAAAATCCTGGTCGGCTCGGAGCCCGCCATCGGGGGCAAGCCCCCTCCCACATTTG

>CP027725|10|10|5232924-5233021|CRISPRCasFinder
ATCGGGAGCAAGCCCCCTCCCACATTTG	GACCGGGATCGACACAAAATCCTGGTCGGCTCGGAGCCCGCC
ATCGGGGGCAAGCCCCCTCCCACATTTG

Protein	Signature genes	Signature genes Name	Protein_function
CP027725.1\|AZE96855.1\|5233065_5233851_-\|Vitamin-B12-ABC-transporter,-B12-binding-component-BtuF	unknown	unknown	gnl\|CDD\|238564
CP027725.1\|AZE96851.1\|5228494_5229634_+\|Fic-domain-protein	unknown	unknown	gnl\|CDD\|225718
CP027725.1\|AZE96846.1\|5224581_5225226_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373093
CP027725.1\|AZE96849.1\|5226753_5227518_-\|Ynd	unknown	unknown	gnl\|CDD\|371541
CP027725.1\|AZE96863.1\|5238943_5239606_-\|Riboflavin-synthase-eubacterial/eukaryotic	unknown	unknown	gnl\|CDD\|236455
CP027725.1\|AZE96859.1\|5235790_5236756_-\|Thiamine-monophosphate-kinase	unknown	unknown	gnl\|CDD\|235583
CP027725.1\|AZE96845.1\|5224012_5224585_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373093
CP027725.1\|AZE96864.1\|5239653_5240781_-\|Diaminohydroxyphosphoribosylaminopyrimidine-deaminase	unknown	unknown	gnl\|CDD\|182729
CP027725.1\|AZE96853.1\|5229947_5230835_+\|(2E,6E)-farnesyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|182567
CP027725.1\|AZE96847.1\|5225222_5226317_+\|ADP-ribose-1-phosphate-phophatase-like-protein	unknown	unknown	gnl\|CDD\|394873
CP027725.1\|AZE96861.1\|5237271_5237748_-\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
CP027725.1\|AZE96860.1\|5236774_5237275_-\|Transcription-termination-protein-NusB	unknown	unknown	gnl\|CDD\|234686
CP027725.1\|AZE96852.1\|5229708_5229951_+\|Exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|179195
CP027725.1\|AZE96848.1\|5226365_5226764_-\|Ync	unknown	unknown	gnl\|CDD\|378065
CP027725.1\|AZE96850.1\|5227725_5228358_+\|Nicotinamidase-family-protein-YcaC	unknown	unknown	gnl\|CDD\|238494
CP027725.1\|AZE96854.1\|5230945_5232844_+\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470
CP027725.1\|AZE96857.1\|5234263_5234881_-\|GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|234745
CP027725.1\|AZE96858.1\|5235010_5235736_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366132
CP027725.1\|AZE96862.1\|5237836_5238928_-\|3,4-dihydroxy-2-butanone-4-phosphate-synthase	unknown	unknown	gnl\|CDD\|237587
CP027725.1\|AZE96856.1\|5233847_5234267_-\|putative-MFS-type-transporter	unknown	unknown	gnl\|CDD\|371064

Protein	Function_ID	Function_description	E-value
CP027725.1\|AZE96855.1\|5233065_5233851_-\|Vitamin-B12-ABC-transporter,-B12-binding-component-BtuF	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	7.37989e-70
CP027725.1\|AZE96851.1\|5228494_5229634_+\|Fic-domain-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.54651e-75
CP027725.1\|AZE96846.1\|5224581_5225226_+\|hypothetical-protein	gnl\|CDD\|373093	pfam14487, DUF4433, Domain of unknown function (DUF4433). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 201 and 230 amino acids in length. There is a single completely conserved residue E that may be functionally important. This family is distantly similar to pfam01885 suggesting these may be ADP-ribosylases.	1.38114e-70
CP027725.1\|AZE96849.1\|5226753_5227518_-\|Ynd	gnl\|CDD\|371541	pfam11459, AbiEi_3, Transcriptional regulator, AbiEi antitoxin, Type IV TA system. AbiEi_3 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.03752e-52
CP027725.1\|AZE96863.1\|5238943_5239606_-\|Riboflavin-synthase-eubacterial/eukaryotic	gnl\|CDD\|236455	PRK09289, PRK09289, riboflavin synthase.	1.67292e-115
CP027725.1\|AZE96859.1\|5235790_5236756_-\|Thiamine-monophosphate-kinase	gnl\|CDD\|235583	PRK05731, PRK05731, thiamine monophosphate kinase; Provisional.	1.4937e-137
CP027725.1\|AZE96845.1\|5224012_5224585_+\|hypothetical-protein	gnl\|CDD\|373093	pfam14487, DUF4433, Domain of unknown function (DUF4433). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 201 and 230 amino acids in length. There is a single completely conserved residue E that may be functionally important. This family is distantly similar to pfam01885 suggesting these may be ADP-ribosylases.	8.40151e-17
CP027725.1\|AZE96864.1\|5239653_5240781_-\|Diaminohydroxyphosphoribosylaminopyrimidine-deaminase	gnl\|CDD\|182729	PRK10786, ribD, bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD.	4.55897e-159
CP027725.1\|AZE96853.1\|5229947_5230835_+\|(2E,6E)-farnesyl-diphosphate-synthase	gnl\|CDD\|182567	PRK10581, PRK10581, (2E,6E)-farnesyl diphosphate synthase.	2.09184e-97
CP027725.1\|AZE96847.1\|5225222_5226317_+\|ADP-ribose-1-phosphate-phophatase-like-protein	gnl\|CDD\|394873	cd02901, Macro_Poa1p-like, macrodomain, Poa1p-like family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family show similarity to the yeast protein Poa1p, reported to be a phosphatase specific for Appr-1"-p, a tRNA splicing metabolite. Poa1p may play a role in tRNA splicing regulation.	1.91608e-37
CP027725.1\|AZE96861.1\|5237271_5237748_-\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	1.04252e-81
CP027725.1\|AZE96860.1\|5236774_5237275_-\|Transcription-termination-protein-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	7.93191e-62
CP027725.1\|AZE96852.1\|5229708_5229951_+\|Exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	1.45944e-21
CP027725.1\|AZE96848.1\|5226365_5226764_-\|Ync	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	3.54571e-11
CP027725.1\|AZE96850.1\|5227725_5228358_+\|Nicotinamidase-family-protein-YcaC	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	2.80859e-69
CP027725.1\|AZE96854.1\|5230945_5232844_+\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
CP027725.1\|AZE96857.1\|5234263_5234881_-\|GTP-cyclohydrolase-II	gnl\|CDD\|234745	PRK00393, ribA, GTP cyclohydrolase II RibA.	7.47264e-138
CP027725.1\|AZE96858.1\|5235010_5235736_-\|hypothetical-protein	gnl\|CDD\|366132	pfam00497, SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3.	3.1331e-09
CP027725.1\|AZE96862.1\|5237836_5238928_-\|3,4-dihydroxy-2-butanone-4-phosphate-synthase	gnl\|CDD\|237587	PRK14019, PRK14019, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
CP027725.1\|AZE96856.1\|5233847_5234267_-\|putative-MFS-type-transporter	gnl\|CDD\|371064	pfam10453, NUFIP1, Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1). Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.	6.02234e-05

>CP027725.1|AZE96854.1|5230945_5232844_+|1-deoxy-D-xylulose-5-phosphate-synthase
MPTTFQEIPRKRPSTPLLDRAATPDGLRRLGEAELETLADELRLELLYTVGQTGGHFGAGLGVIELTIALHYVFDTPDDRLVWDVGHQAYPHKILTGRRERMASLRQKDGIAAFPRRSESEYDTFGVGHSSTSISAALGMAIAARLQGSERKAIAVIGDGALTAGMAFEALNHAPEVDANMLVILNDNDMSISRNVGGLSNYLAKILSSRTYASMREGSKKVLSRLPGAWEIARRTEEYAKGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHIVTKKGKGFAPAEVDPIGYHAITKLEPLDAPAAAPKKASGPKYSGVFGEWLCDMAAADPRLVGITPAMKEGSDLVAFSERFPLRYFDVAIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRGYDQLVHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKMLSTGHLYNGPAAVRYPRGNGPNAVIEKDLEPIEIGKGILRRQGSKTAFLVFGVQLAEVLKVAEKLDATVVDMRFVKPLDEALVREIAGSHELLVTVEENAIMGGAGAAVSEFLARENILKSVLHLGLPDMYVEHAKPAQMLAECGLDEVGIEASVRQRMALLAL
>CP027725.1|AZE96853.1|5229947_5230835_+|(2E,6E)-farnesyl-diphosphate-synthase
MIDAYQASSQARVNAALEPLFVAPSPEMNRLYAAMRYSVMNGGKRVRPLLAYAACEALGAPAEQANGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKAFDEAYAILAGDGLQSLAFSALLDPALSSVNAEIRLRMVTVLALAAGPAGMVGGQAIDMGSVSLKLDQHALEHMHRHKTGALIEAAVQLGALASGRAEAAQLAALHTYSRAIGLAFQVQDDILDVESDTATLGKRQGADVARDKPTYPALLGLAAAKGYALELRDQALDALRPFDAAAEPLRDLARYIVERRH
>CP027725.1|AZE96852.1|5229708_5229951_+|Exodeoxyribonuclease-VII-small-subunit
MARKKVALDFEQSLADLQTLVERLENGELSLEDSLTAFEQGIGLTRDCQSALAQAEQKVQVLLERDGELAEEPFDAEQPE
>CP027725.1|AZE96851.1|5228494_5229634_+|Fic-domain-protein
MDHPHWIWQHLDWPHFHWQPGRLGPLLRECGQAQGRLLGMLGTDSQAVNAQNELDALLQNILTSSAIEGEQLNVDSVRSSLARRLGLQPLKNASVSRRSEGLAELMMNATQQYSQPFTLDRLLNWHHLLFPTPDAGYIAQALNVGALRGDEPMQVVSGRLDRPTVHFEAPPREGLEHALGEFLEWFETSRDQPELDSLVRAGVAHFWFVTLHPFDDGNGRLTRAITDLALAQAEHQAIRFYAMSASILEDRTGYYEALESSQKATLDITDWLEWFLKTLLRSVQQAMARIDRVLHKSRFWQRRRDLVLSAEQIKVLNRLLDGGERGFEQGISAAQYQAVAKVSKATATRHLGDLLEKNCLIRLPGGGRSTRYQINTAGE
>CP027725.1|AZE96850.1|5227725_5228358_+|Nicotinamidase-family-protein-YcaC
MSAPTYNRLNKDDAIVLLVDHQTGLISLVQDFSPNEFKNNVLALADLAKFFNLPTILTTSFEQGPNGPLVPELKEMFPDAPYIARPGQINAWDNEDFVKAIKATGRKQIIIAGVVTDVCVAFPTLSALAEGFEVFVVTDASGTFNTTVQQAAWSRMTQAGAQLMNWFSVACELHRDWRNDIEGLGNLLSQRIPNYRNLMNGYAALTAQQK
>CP027725.1|AZE96849.1|5226753_5227518_-|Ynd
MKINRLLANWPSGTIVTQAWLHEQGVGPNLIQKYQQTGWVERVGHGAWKRCGDSIDWHAGVFALQQGATVQIWPGGATALSLAGYSHYLTFGKENVDLFGTSGAVLPGWFRKHEWEAQMNFHPGALFTGLEDMALQVFQMPYRQFALKISTPERAVLELIHQSADEMLFSGVADVMNGLATLSPRRLQKLLEACNSIRVKRVFFVLARNAAHAWYARIDRSSIELGKGKRQIIRGGRLDKEFLITVPERFAHAT
>CP027725.1|AZE96848.1|5226365_5226764_-|Ync
MPLDPRYAAQVRLLVQVIPYVAAERCFALKGGTAINLFVRDLPRLSVDIDLAYLPSADRQQALVDVRQALKRIADAIGRGLPGAVATVQRNREYELRILVRSAHAQISNSHATENQFINCTPVWVVYLWGSS
>CP027725.1|AZE96847.1|5225222_5226317_+|ADP-ribose-1-phosphate-phophatase-like-protein
MIRFTQGNLLQANTEVLVNTVNTVGVMGKGIALMFKERFAENYRLYAAACKAGEVETGKVHVTAVNELDGPRWIVNFPTKRHWRSPSQMAWITEGLHDLRRFLIENHVKSVAVPPLGAGNGGLKWLDVREQIEDVLSDLDVDVLVFEPSNQYLNVAKRSGVEQLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIEKRPGLKNPLDLKFVAHKYGPYANRLEHLLNNLDGSYLHCDKRISDAENSDVIWFDQDRRAFLQTYLRTEAKEYSQALELTAALIDGFESPFGMELLATVDWLLTQEDVAPTVPAVREALKRWDGGVAAAARKNKLFDDQALDIALKRLTSSSFSHQMASCHI
>CP027725.1|AZE96846.1|5224581_5225226_+|hypothetical-protein
MIYNNLNPEKALIWRIVHRDNLPWILDNGLHCASSEVQAAQYVNIGNVDLIDKRRTRCVPIAPSGFLSDYVPFYFTPFSVMMKNIHSGWSVQQRNNDEIVILVSSLHRVAELGLPFVFTNAHAYPDWTDYYSDLADLHEIDWSILQRRDFKRDPDDPRKMERYQAEALIHHHLPITGLLGIMCYTDAMKERIEQDVAARGLTLPVYARPGWYFP
>CP027725.1|AZE96845.1|5224012_5224585_+|hypothetical-protein
MPDIKEQKLLYHLTSLENLSGIFQHGLKPRAQLRAFEDVADADILKKRQGLALDQYVPFHWFAANPFDGSVQRRRPDTQFVVITVHRNVAIRKQWKVIPRHPLANDAIQLLDYADGFESINWELMNARDYHDPQCKSICMAECLSPDVVSPNDFFKVFVSNAEVEALCESKMREAGVNVQIGVNRGMFLR
>CP027725.1|AZE96855.1|5233065_5233851_-|Vitamin-B12-ABC-transporter,-B12-binding-component-BtuF
MKRYWLALLLVFSAQAWAVERVVSLAPSLSEIVVELGAADVLVGVLDGGDRPAALVNLPSVGRYGQLDMERLLSLKPDLILLWPGSVGPAQREQLQRLKIPVYVAEPHNLEQLTTQVQAIAEQLDRADAGLALADQLRQRLAELRQRYRRAEPLRVFYQVWNQPLYTVGGGQIISDALQVCGARNVFDDLKLPAPQVSIESVLQRDPQLILVGDQAQREAWKVWPTMFERVRLVPDKGLERPSGQMLEAVARLCQVIAPDL
>CP027725.1|AZE96856.1|5233847_5234267_-|putative-MFS-type-transporter
MTRGQVKRRLSFNWWQYLALALLPLFVINLVFGRAESLLPVLAMPFFIAGVASMFLSLRYFHAYKHALIATSKALDTPEEPAAWITLAARRRTALLVAALPAWIGALAVFVGLEAVPLFLLALSTTVLFYLYRIPRQLG
>CP027725.1|AZE96857.1|5234263_5234881_-|GTP-cyclohydrolase-II
MPVVFVAASKLPTPFATFTMHGFLEEATGREHVVLSLGDIADGAPVLGRVHSECLTGDALFSQRCDCGSQLEAALQAIAREGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANERLGFAADQRDYAICLPMLEHLGVKSLRLMTNNPRKVKALTEMGITVAERVPLHTGHNPHNKLYLATKASKLDHMMGNEHQGEVDRA
>CP027725.1|AZE96858.1|5235010_5235736_-|hypothetical-protein
MSVRCWLLIMLCVLTSVLEADEARVPDKIVLASEEWNDYTNNDGSGLAWDVLRRVFEPAGVTLQTRSVPYTRSIGLAQRGEVDGWVGSYRDEAEHVLYPQWPFDADHIYALGLATLPTPNLATLGDYRLAWVRGYKYEQYLPNVRRFNQVQRRSGILSMLQYGHADFYIEALTEARYVLSQADEPSRYRLTHLMDLPLYIGFVDNERGRALVAVFDQRMTALVKNGELRPIFERWKQPYPF
>CP027725.1|AZE96859.1|5235790_5236756_-|Thiamine-monophosphate-kinase
MGEFELIRNYFAAAPCAQGGEGITLGIGDDCALLALPAGEQLAVSTDTLVAGVHFADPCDPFLLGQRSLAVAVSDLAAMGAHPLAFTLALTTPTVDADWLQRYAQGLNAMAQRCGVGLVGGDTTRGPLSLTLTVFGRVPAGLALTRSGARPGDLLCVGGELGNAAGALPLVLGQRSAQAAIAEPLLAHYWSPQPQLGLGLALRGKATSAMDISDGLLADCGHIARASTVSLVIERDILPLSAALRAFVGDDEARVAALSGGDDYVLVFTLPQAELAALRAGGWPIHVIGRVEAGQGVTLLDTHGQDVTPAVHGYQHFHELP
>CP027725.1|AZE96860.1|5236774_5237275_-|Transcription-termination-protein-NusB
MISDESDRFNPRDERPADAGKPSKSEKRRAARQLATQALYQRHMAGTSLNEIEAQFRVDNDFTFADQSYFHDILHGVPANLDEIDAALTPCLDLTLEELDPVELAVLRLSTWELLKRVDVPYRVVINEGIELAKVYGSTDGHKFVNGVLDKLAPRLREAEVKEHKR
>CP027725.1|AZE96861.1|5237271_5237748_-|6,7-dimethyl-8-ribityllumazine-synthase
MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVIESDITLIRAPGAFEIPLVAQKVAQQGEYAAIIALGAVIRGGTPHFEYVAGECTKGLAQVSMEFGVPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLSQLEAK
>CP027725.1|AZE96862.1|5237836_5238928_-|3,4-dihydroxy-2-butanone-4-phosphate-synthase
MALNSIEELVEDIRQGKMVILMDDEDRENEGDIIMAAEACKPEHINFMAKHARGLICMPMSRERCELLKLPLMAPRNGSGFGTKFTVSIEATTGVTTGISAADRARTVQAAAAKDAKAEDIVSPGHIFPLMAQPGGTLARAGHTEAACDLARMAGFEPSGVICEVMNDDGTMARRSELEAFAAEHNIKVGTIADLIHYRMIHERTVQRIAEQPLDSELGQFNLVTYRDSVEGDVHMALTLGNICADEPTLVRVHNMDPLRDLLMVKQPGRWSLRAAMAAVSEAGSGVVLLLGHPVDGDALLAHIRETADHVPVKKPTTYSIVGAGSQILRDLGVRKMRLMSAPMKFNAISGFDLEVVEYVPSE
>CP027725.1|AZE96863.1|5238943_5239606_-|Riboflavin-synthase-eubacterial/eukaryotic
MFTGIIESIGSIRAMTPKGGDIRLLVETGKLDLGDVKLGDSIAVSGVCLTVVELPGNGFAADVSRETLDCTAMSDLAAGSPVNLEKALTPTTRLGGHLVSGHVDGVGEVVARSENARAVEFRIRAPKELAKYIAHKGSITVDGTSLTVNAVNGAEFELTIIPHTLSETIMASYQPGRRVNLEVDLLARYLERLLLGEKAAEPASGNITESFLAANGYLKS
>CP027725.1|AZE96864.1|5239653_5240781_-|Diaminohydroxyphosphoribosylaminopyrimidine-deaminase
MTAEQAVLDAHYMARALELARKGLYTTHPNPRVGCVIVRDGQIVGEGWHERTGEPHAEPNALRAAGDKARGATVYVTLEPCSHHGRTPPCADALVSAGVARVVAGMQDPNPEVAGRGMQRLAQAGIDIRSGVLESQARALNPGFLKRMEHGLPFVRVKLAMSLDGRTAMASGESQWITGPAARAAVQRLRAEASVVLTGADTVLADGARLTVRAAELGLDEETTALVMSRPPLRVLIDGRLRVPLNAPFFKAGPALVITCVTPENQFPRGPECLVVPGVEGQVDLRSALMALAARGVNDVLVEAGPSLAGAFAQQGLVDEYVIFVAGKFLGSAARPLLDWPLEKLADAPQLKITDMRAVGDDWRVTAIPVPAASV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	3018655-3018688	1	0.971
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	706952-706985	2	0.941
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	707022-707055	2	0.941
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	718003-718036	2	0.941
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	1260797-1260830	2	0.941
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	1260867-1260900	2	0.941
CP027725_5	5.1\|2555945\|34\|CP027725\|CRISPRCasFinder	2555945-2555978	34	CP027725.1	2571713-2571746	2	0.941
CP027725_7	7.1\|3555219\|44\|CP027725\|CRISPRCasFinder	3555219-3555262	44	CP027725.1	3169964-3170007	2	0.955

1. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 3018655-3018688, mismatch: 1, identity: 0.971

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttgggccgggatcgacacaaa	Protospacer
**********************.***********

2. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 706952-706985, mismatch: 2, identity: 0.941

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttggaccgggatcgacacaaa	Protospacer
*****************.****.***********

3. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 707022-707055, mismatch: 2, identity: 0.941

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttggaccgggatcgacacaaa	Protospacer
*****************.****.***********

4. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 718003-718036, mismatch: 2, identity: 0.941

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttggaccgggatcgacacaaa	Protospacer
*****************.****.***********

5. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 1260797-1260830, mismatch: 2, identity: 0.941

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttggaccgggatcgacacaaa	Protospacer
*****************.****.***********

6. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 1260867-1260900, mismatch: 2, identity: 0.941

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttggaccgggatcgacacaaa	Protospacer
*****************.****.***********

7. spacer 5.1|2555945|34|CP027725|CRISPRCasFinder matches to position: 2571713-2571746, mismatch: 2, identity: 0.941

ccccctcccacatttgggccggaatcgacacaaa	CRISPR spacer
ccccctcccacatttgagccgggatcgacacaaa	Protospacer
****************.*****.***********

8. spacer 7.1|3555219|44|CP027725|CRISPRCasFinder matches to position: 3169964-3170007, mismatch: 2, identity: 0.955

tcccacatttggaccgggatcgacacaaaagcccggtcggccca	CRISPR spacer
tcccacatttggaccaggatcgacacaaaatcccggtcggccca	Protospacer
***************.************** *************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1305416 : 1344509

uncultured_Caudovirales_phage(31.82%)

tail,tRNA,plate

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZE93282.1\|1305416_1305887_+\|tRNA	Cys-tRNA(Pro) deacylase YbaK	NA	NA	NA	NA
AZE93283.1\|1306018_1307074_-	Ferric iron ABC transporter, ATP-binding protein	Q6GZ03	Mycoplasma_phage	3.9e-21	37.7
AZE93284.1\|1307070_1307994_-	Ornithine carbamoyltransferase	A0A1J0F9B8	Only_Syngen_Nebraska_virus	2.7e-18	27.4
AZE93285.1\|1308235_1308397_+	hypothetical protein	NA	NA	NA	NA
AZE93286.1\|1308424_1310533_+	Formate dehydrogenase-O, major subunit	NA	NA	NA	NA
AZE93287.1\|1310632_1310971_+	Glutaredoxin-related protein	NA	NA	NA	NA
AZE93288.1\|1311038_1311509_-	Bacterioferritin	NA	NA	NA	NA
AZE93289.1\|1311709_1311928_-	Bacterioferritin-associated ferredoxin	NA	NA	NA	NA
AZE93290.1\|1312172_1312775_+	Alkyl hydroperoxide reductase subunit C-like protein	NA	NA	NA	NA
AZE93291.1\|1312839_1313514_-	Ribonuclease T	NA	NA	NA	NA
AZE93292.1\|1313510_1314557_-	Dihydroorotase	NA	NA	NA	NA
AZE93293.1\|1314713_1315622_+	Sodium-type flagellar protein motY precursor	NA	NA	NA	NA
AZE93294.1\|1315751_1316969_+	Argininosuccinate synthase	NA	NA	NA	NA
AZE93295.1\|1317596_1318229_+	Two-component transcriptional response regulator, LuxR family	NA	NA	NA	NA
AZE93296.1\|1318317_1318500_-	hypothetical protein	NA	NA	NA	NA
AZE93297.1\|1318608_1319247_-	Endonuclease III	NA	NA	NA	NA
AZE93298.1\|1319315_1320296_-	Electron transport complex protein RnfB	NA	NA	NA	NA
AZE93299.1\|1320383_1322435_-\|tRNA	Methionyl-tRNA synthetase	NA	NA	NA	NA
AZE93300.1\|1322606_1323701_+	[4Fe-4S] cluster assembly scaffold protein Mrp (ApbC)	NA	NA	NA	NA
AZE93301.1\|1324162_1324486_-	4Fe-4S dicluster domain	NA	NA	NA	NA
AZE93302.1\|1324628_1327220_-	DNA mismatch repair protein MutS	A0A1V0SJ67	Klosneuvirus	2.8e-28	21.5
AZE93303.1\|1327574_1327946_-	hypothetical protein	NA	NA	NA	NA
AZE93304.1\|1327938_1328427_-	GepA protein	D0UIM3	Aggregatibacter_phage	6.4e-27	43.8
AZE93305.1\|1328659_1329394_+	Transcriptional regulator	B5TK58	Pseudomonas_phage	4.1e-118	86.5
AZE93306.1\|1329560_1329683_-	hypothetical protein	NA	NA	NA	NA
AZE93307.1\|1329988_1330327_+	Holin	B5TK61	Pseudomonas_phage	9.5e-46	81.2
AZE93308.1\|1330346_1330862_+	hypothetical protein	NA	NA	NA	NA
AZE93309.1\|1330865_1331474_+\|plate	Baseplate assembly protein V	A0A2H4JBW8	uncultured_Caudovirales_phage	5.5e-44	51.7
AZE93310.1\|1331486_1331819_+\|plate	Baseplate assembly protein W	A0A2H4JI46	uncultured_Caudovirales_phage	3.9e-36	68.2
AZE93311.1\|1331815_1332811_+\|plate	Phage-related baseplate assembly protein	A0A2H4JC04	uncultured_Caudovirales_phage	1.5e-110	63.5
AZE93312.1\|1332807_1333536_+\|tail	Phage tail fiber	A0A2H4JDK0	uncultured_Caudovirales_phage	9.3e-38	51.2
AZE93313.1\|1333532_1334063_+\|tail	Phage tail fiber protein	B0ZSG1	Halomonas_phage	1.9e-48	56.3
AZE93314.1\|1334110_1334896_+	hypothetical protein	NA	NA	NA	NA
AZE93315.1\|1334896_1335199_+	Phage protein	Q8H9M8	Vibrio_phage	5.6e-13	48.0
AZE93316.1\|1335284_1335458_+	hypothetical protein	NA	NA	NA	NA
AZE93317.1\|1335460_1336627_+\|tail	Major tail sheath protein	B0ZSG8	Halomonas_phage	1.6e-124	56.7
AZE93318.1\|1336626_1337133_+	hypothetical protein	Q6R4W3	Vibrio_virus	6.5e-22	35.1
AZE93319.1\|1337185_1337767_+	hypothetical protein	B0ZSH0	Halomonas_phage	5.3e-28	37.7
AZE93320.1\|1337763_1337889_+	hypothetical protein	NA	NA	NA	NA
AZE93321.1\|1337895_1340118_+\|tail	Phage tail length tape-measure protein	NA	NA	NA	NA
AZE93322.1\|1340117_1340501_+\|tail	Unclassified tail protein	A0A2H4JAC8	uncultured_Caudovirales_phage	6.6e-35	57.5
AZE93323.1\|1340493_1340706_+\|tail	P2-like prophage tail protein X	A0A2H4JGD9	uncultured_Caudovirales_phage	9.0e-18	64.3
AZE93324.1\|1340715_1341717_+\|tail	Phage tail protein D	A0A2H4JH05	uncultured_Caudovirales_phage	1.2e-96	53.3
AZE93325.1\|1341739_1342297_+	Lytic enzyme	B5TK83	Pseudomonas_phage	1.0e-73	71.0
AZE93326.1\|1342284_1342785_+	hypothetical protein	B5TK84	Pseudomonas_phage	2.0e-31	50.3
AZE93327.1\|1342866_1343367_+	Nicotinamide-nucleotide amidase	B5TK85	Pseudomonas_phage	5.7e-71	83.7
AZE93328.1\|1343450_1344509_+	RecA protein	A0A0S2MVG1	Bacillus_phage	2.4e-111	62.4

DBSCAN-SWA_2

1448429 : 1453391

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZE93430.1\|1448429_1449179_+	5'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	3.3e-62	49.8
AZE93431.1\|1449178_1449856_+	Protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	3.1e-43	53.1
AZE93432.1\|1450064_1450901_+	Murein hydrolase activator NlpD	A0A0S2SXL7	Bacillus_phage	8.2e-06	33.3
AZE93433.1\|1451006_1452014_+	RNA polymerase sigma factor RpoS	G8CLC7	Synechococcus_phage	1.3e-34	36.2
AZE93434.1\|1452226_1452436_-	Cold shock protein of CSP family	Q9AZD3	Lactococcus_phage	2.2e-16	66.7
AZE93435.1\|1452662_1452803_-	hypothetical protein	NA	NA	NA	NA
AZE93436.1\|1452824_1453391_+	Deoxycytidine triphosphate deaminase	S5VM63	Pseudomonas_phage	6.2e-74	73.3

DBSCAN-SWA_3

3367921 : 3404769

Pseudomonas_phage(71.79%)

terminase,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZE95111.1\|3367921_3368131_+	hypothetical protein	A0A2D1GNR5	Pseudomonas_phage	1.8e-10	57.1
AZE95112.1\|3368134_3369409_-	Error-prone, lesion bypass DNA polymerase V (UmuC)	I6RSM4	Salmonella_phage	5.5e-110	50.4
AZE95113.1\|3369401_3369566_-	Error-prone repair protein UmuD	NA	NA	NA	NA
AZE95114.1\|3369572_3369695_+	hypothetical protein	NA	NA	NA	NA
AZE95115.1\|3369928_3370609_+	Gifsy-2 prophage protein	A0A2H4J991	uncultured_Caudovirales_phage	1.9e-122	90.5
AZE95116.1\|3370785_3371328_-	hypothetical protein	A0A2H4IZW4	uncultured_Caudovirales_phage	2.4e-43	60.3
AZE95117.1\|3371324_3371858_-	Phage endolysin	A0A059VA40	Pseudomonas_phage	1.1e-75	79.7
AZE95118.1\|3371914_3372469_-\|tail	tail fiber assembly domain protein	A0A2H4J9Z7	uncultured_Caudovirales_phage	9.3e-14	58.7
AZE95119.1\|3372469_3373243_-	hypothetical protein	G8C7R8	Escherichia_phage	1.6e-11	26.2
AZE95120.1\|3373292_3373973_-	hypothetical protein	A0A059VF40	Pseudomonas_phage	3.5e-23	34.6
AZE95121.1\|3374301_3378264_-\|tail	Phage tail fiber protein	A0A1B0VMH5	Pseudomonas_phage	0.0e+00	67.3
AZE95122.1\|3378323_3378917_-\|tail	Phage tail assembly protein I	A0A1B0VMI5	Pseudomonas_phage	4.2e-97	94.4
AZE95123.1\|3378974_3379397_-	putative lipoprotein	A0A1B0VMH3	Pseudomonas_phage	3.8e-68	95.7
AZE95124.1\|3380277_3380433_-	hypothetical protein	NA	NA	NA	NA
AZE95125.1\|3380572_3380830_+	hypothetical protein	NA	NA	NA	NA
AZE95126.1\|3381145_3381298_-	hypothetical protein	NA	NA	NA	NA
AZE95127.1\|3381323_3382088_-\|tail	Phage tail assembly protein	A0A1B0VP68	Pseudomonas_phage	1.1e-137	87.6
AZE95128.1\|3382090_3382843_-\|tail	Phage minor tail protein	A0A1B0VNE0	Pseudomonas_phage	1.1e-139	92.8
AZE95129.1\|3382854_3383193_-\|tail	Phage minor tail protein	A0A1B0VMG7	Pseudomonas_phage	3.9e-55	84.8
AZE95130.1\|3383192_3386237_-\|tail	Phage tail length tape-measure protein 1	A0A1B0VMG8	Pseudomonas_phage	1.2e-195	41.9
AZE95131.1\|3386264_3386585_-	hypothetical protein	A0A1B0VMG9	Pseudomonas_phage	2.4e-22	55.2
AZE95132.1\|3386584_3386884_-	hypothetical protein	A0A2H4IYQ5	uncultured_Caudovirales_phage	1.5e-18	49.0
AZE95133.1\|3386967_3387639_-	hypothetical protein	A0A0H5BBY3	Pseudomonas_phage	8.5e-46	44.2
AZE95134.1\|3387708_3388128_-	hypothetical protein	A0A1B0VMI0	Pseudomonas_phage	2.9e-60	83.9
AZE95135.1\|3388124_3388781_-	hypothetical protein	A0A1B0VMI1	Pseudomonas_phage	2.2e-83	72.9
AZE95136.1\|3388777_3389149_-	phage-related conserved hypothetical protein	A0A1B0VRJ4	Pseudomonas_phage	4.0e-61	95.1
AZE95137.1\|3389166_3389667_-	phage-related conserved hypothetical protein	A0A1B0VND3	Pseudomonas_phage	1.7e-75	86.7
AZE95138.1\|3389669_3390119_-	hypothetical protein	NA	NA	NA	NA
AZE95139.1\|3390165_3391128_-	putative phage protein	A0A1B0VMF8	Pseudomonas_phage	3.7e-167	93.1
AZE95140.1\|3391140_3391869_-	hypothetical protein	A0A1B0VMG1	Pseudomonas_phage	2.3e-121	94.6
AZE95141.1\|3391951_3393037_-	Phage protein	A0A1B0VMF3	Pseudomonas_phage	3.8e-189	95.6
AZE95142.1\|3393011_3394430_-	structural protein	A0A1B0VMH0	Pseudomonas_phage	3.0e-258	91.1
AZE95143.1\|3394426_3395728_-\|terminase	Phage terminase	A0A1B1P9C9	Acinetobacter_phage	3.0e-148	59.9
AZE95144.1\|3395714_3396176_-	Phage protein	A0A0S2SY97	Pseudomonas_phage	5.5e-44	69.9
AZE95145.1\|3396207_3396810_-	hypothetical protein	A0A1B0VRJ1	Pseudomonas_phage	1.2e-107	93.1
AZE95146.1\|3396897_3397230_+	hypothetical protein	NA	NA	NA	NA
AZE95147.1\|3397296_3397641_-	hypothetical protein	A0A193GYR7	Enterobacter_phage	1.6e-08	37.9
AZE95148.1\|3397637_3397967_-	hypothetical protein	A0A088FVG2	Escherichia_phage	5.5e-22	48.6
AZE95149.1\|3398034_3398637_+	hypothetical protein	NA	NA	NA	NA
AZE95150.1\|3399084_3399630_-	hypothetical protein	A0A0H5AWB8	Pseudomonas_phage	1.1e-56	61.9
AZE95151.1\|3399626_3400202_-	NinG recombination protein	A0A125RNK9	Pseudomonas_phage	1.5e-67	63.2
AZE95152.1\|3400198_3400669_-	hypothetical protein	A0A2H4J106	uncultured_Caudovirales_phage	7.3e-52	60.3
AZE95153.1\|3400665_3401463_-	hypothetical protein	A0A1B0VMD9	Pseudomonas_phage	2.2e-93	65.4
AZE95154.1\|3401449_3401848_-	Primosomal protein I	A0A1B0VME0	Pseudomonas_phage	8.3e-41	63.3
AZE95155.1\|3402357_3402945_-	hypothetical protein	A0A1B0VME0	Pseudomonas_phage	1.5e-38	67.5
AZE95156.1\|3403121_3403736_-	hypothetical protein	NA	NA	NA	NA
AZE95157.1\|3403790_3404018_-	Cro repressor-like protein	A0A127KNT2	Pseudomonas_phage	6.9e-08	40.9
AZE95158.1\|3404124_3404769_+	Putative cI prophage repressor protein	K7PH71	Enterobacterial_phage	5.8e-52	51.6

DBSCAN-SWA_4

3410479 : 3426909

Pseudomonas_phage(31.25%)

integrase

attL 3404970:3404989|attR 3431734:3431753

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3404970:3404989	attL	NA	NA	NA	NA
AZE95165.1\|3410479_3410917_+	hypothetical protein	A0A1B0VMC3	Pseudomonas_phage	1.2e-61	78.6
AZE95166.1\|3410913_3411105_+	hypothetical protein	A0A1B0VMB8	Pseudomonas_phage	8.6e-20	76.2
AZE95167.1\|3411101_3411296_+	hypothetical protein	NA	NA	NA	NA
AZE95168.1\|3411319_3411409_+	hypothetical protein	NA	NA	NA	NA
AZE95169.1\|3411454_3412549_+	hypothetical protein	A0A0A1IUM6	Pseudomonas_phage	4.4e-92	49.4
AZE95170.1\|3412548_3413292_+	Phage exonuclease	H2BDF8	Pseudomonas_virus	2.6e-43	39.6
AZE95171.1\|3413288_3413852_+	hypothetical protein	A0A2H4IZG3	uncultured_Caudovirales_phage	1.9e-67	71.1
AZE95172.1\|3413859_3414102_+	hypothetical protein	NA	NA	NA	NA
AZE95173.1\|3414098_3414569_+	hypothetical protein	A0A2H4J101	uncultured_Caudovirales_phage	8.3e-72	86.1
AZE95174.1\|3414556_3415057_+	hypothetical protein	A0A1B0VMB5	Pseudomonas_phage	1.6e-60	73.4
AZE95175.1\|3415096_3415366_-	hypothetical protein	NA	NA	NA	NA
AZE95176.1\|3415476_3416484_+	Nucleoid-associated protein	L7TI92	Pseudomonas_virus	9.0e-124	65.4
AZE95177.1\|3416535_3417165_+	Phage protein	NA	NA	NA	NA
AZE95178.1\|3417245_3418052_-	hypothetical protein	NA	NA	NA	NA
AZE95179.1\|3418113_3420336_+	C-5 cytosine-specific DNA methylase family protein	Q5QF27	Pseudomonas_virus	4.4e-248	59.4
AZE95180.1\|3420579_3421011_+	hypothetical protein	NA	NA	NA	NA
AZE95181.1\|3421007_3421253_+	hypothetical protein	A0A1B0YZW9	Pseudomonas_phage	5.9e-13	47.1
AZE95182.1\|3421304_3421592_-	hypothetical protein	NA	NA	NA	NA
AZE95183.1\|3422062_3422554_+	hypothetical protein	NA	NA	NA	NA
AZE95184.1\|3422534_3422921_+	Phage-associated homing endonuclease	K7P7B7	Enterobacteria_phage	3.0e-27	46.4
AZE95185.1\|3422917_3423667_+	Phage protein	Q5QF30	Pseudomonas_virus	5.9e-72	59.8
AZE95186.1\|3423716_3423983_+	hypothetical protein	NA	NA	NA	NA
AZE95187.1\|3424031_3424526_+	hypothetical protein	L7TI83	Pseudomonas_virus	1.6e-33	46.2
AZE95188.1\|3424562_3424799_+	hypothetical protein	A0A2H4JF29	uncultured_Caudovirales_phage	4.8e-28	74.4
AZE95189.1\|3424803_3425868_+\|integrase	Phage integrase family protein	A0A2H4JDJ8	uncultured_Caudovirales_phage	1.1e-148	76.3
AZE95190.1\|3426237_3426909_+	Putative TEGT family carrier/transport protein	A0A2H4JFM9	uncultured_Caudovirales_phage	3.0e-107	93.7
3431734:3431753	attR	NA	NA	NA	NA

DBSCAN-SWA_5

3448254 : 3454480

uncultured_Caudovirales_phage(83.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZE95216.1\|3448254_3448647_+\|tRNA	tRNA 5-methylaminomethyl-2-thiouridine synthase subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	2.9e-54	81.4
AZE95217.1\|3448648_3448999_+\|tRNA	tRNA 5-methylaminomethyl-2-thiouridine synthase subunit TusC	A0A2H4J8C0	uncultured_Caudovirales_phage	8.9e-39	71.1
AZE95218.1\|3448998_3449277_+\|tRNA	tRNA 5-methylaminomethyl-2-thiouridine synthase TusB	A0A2H4JG28	uncultured_Caudovirales_phage	3.4e-25	59.6
AZE95219.1\|3449273_3449609_+\|tRNA	tRNA 2-thiouridine synthesis protein TusE	A0A2H4J8B6	uncultured_Caudovirales_phage	1.5e-43	75.7
AZE95220.1\|3449605_3450607_+	Anthranilate phosphoribosyltransferase like	A0A2H4JBY5	uncultured_Caudovirales_phage	1.6e-165	85.7
AZE95221.1\|3450695_3451691_+	Glutathione S-transferase, omega	NA	NA	NA	NA
AZE95222.1\|3451804_3453199_-	Precorrin-2 oxidase	NA	NA	NA	NA
AZE95223.1\|3453199_3454480_-\|tRNA	Seryl-tRNA synthetase	A0A1B1IVT2	uncultured_Mediterranean_phage	5.3e-97	53.0

DBSCAN-SWA_6

4305566 : 4337516

Pseudomonas_phage(75.0%)

integrase,head,terminase,tail,capsid

attL 4300186:4300202|attR 4344278:4344294

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4300186:4300202	attL	NA	NA	NA	NA
AZE95979.1\|4305566_4305947_+\|integrase	Phage integrase, site-specific tyrosine recombinase	Q76UT6	Pseudomonas_virus	4.1e-29	37.4
AZE95980.1\|4305976_4306588_+	hypothetical protein	NA	NA	NA	NA
AZE95981.1\|4307356_4307572_+	hypothetical protein	A0A2H4J177	uncultured_Caudovirales_phage	6.1e-22	81.8
AZE95982.1\|4308192_4309767_+	hypothetical protein	NA	NA	NA	NA
AZE95983.1\|4309943_4310915_-	hypothetical protein	A0A0U4IBV2	Pseudomonas_phage	1.7e-116	64.6
AZE95984.1\|4310887_4311592_-	hypothetical protein	A0A1D9CA29	Salinivibrio_phage	2.3e-41	38.3
AZE95985.1\|4311588_4312140_-	hypothetical protein	A0A0U4J942	Pseudomonas_phage	4.8e-55	64.1
AZE95986.1\|4312136_4313039_-	hypothetical protein	NA	NA	NA	NA
AZE95987.1\|4313061_4313700_-	hypothetical protein	NA	NA	NA	NA
AZE95988.1\|4313702_4316339_-\|tail	Phage tail fiber protein	A0A0U4K5K2	Pseudomonas_phage	2.4e-104	63.2
AZE95989.1\|4316348_4316873_-	hypothetical protein	A0A0U4JVX3	Pseudomonas_phage	1.5e-82	81.6
AZE95990.1\|4316869_4318042_-	Phage protein	A0A0U4JJ14	Pseudomonas_phage	1.0e-166	74.3
AZE95991.1\|4318038_4318356_-	hypothetical protein	A0A0U4B0N5	Pseudomonas_phage	1.1e-35	79.4
AZE95992.1\|4318352_4320665_-	Phage tape measure	A0A0U4IJ81	Pseudomonas_phage	2.7e-147	41.9
AZE95993.1\|4320671_4320812_-	hypothetical protein	A0A0U4B0S4	Pseudomonas_phage	9.4e-16	82.6
AZE95994.1\|4320835_4321123_-	hypothetical protein	A0A0U4B0P2	Pseudomonas_phage	1.5e-28	68.4
AZE95995.1\|4321136_4321613_-	Endopeptidase	A0A0U4JXC2	Pseudomonas_phage	2.2e-27	51.6
AZE95996.1\|4321612_4322146_-	putative phage lysozyme	NA	NA	NA	NA
AZE95997.1\|4322142_4322349_-	hypothetical protein	NA	NA	NA	NA
AZE95998.1\|4322345_4322564_-	putative Zinc-finger containing protein	A0A0U4IIN4	Pseudomonas_phage	6.8e-13	58.5
AZE95999.1\|4322563_4323013_-	hypothetical protein	A0A0U3TH58	Pseudomonas_phage	1.5e-59	75.0
AZE96000.1\|4323019_4324141_-	Phage protein	A0A0U4KLE6	Pseudomonas_phage	4.0e-141	68.6
AZE96001.1\|4324152_4324833_-	hypothetical protein	A0A0U4ISN1	Pseudomonas_phage	3.2e-64	61.1
AZE96002.1\|4324822_4325272_-	hypothetical protein	A0A0U4IBS7	Pseudomonas_phage	2.5e-49	66.7
AZE96003.1\|4325268_4325739_-\|head	putative head completion/stabilization protein	A0A0U4J933	Pseudomonas_phage	1.5e-36	57.1
AZE96004.1\|4325837_4326563_-\|terminase	putative terminase, endonuclease subunit	A0A0U4JEJ1	Pseudomonas_phage	2.6e-72	64.7
AZE96005.1\|4326559_4327579_-\|capsid	Phage capsid protein	A0A0U4K5I9	Pseudomonas_phage	2.5e-126	68.5
AZE96006.1\|4327580_4328495_-\|capsid	Phage capsid scaffolding protein	A0A0U4JVV6	Pseudomonas_phage	1.1e-59	45.3
AZE96007.1\|4328658_4330710_+\|terminase	Phage terminase, ATPase subunit	A0A0U4JIZ9	Pseudomonas_phage	6.4e-262	67.8
AZE96008.1\|4330744_4331500_+\|capsid	Phage capsid and scaffold	A0A0U4B0L9	Pseudomonas_phage	9.4e-102	76.9
AZE96009.1\|4331908_4332454_+	hypothetical protein	NA	NA	NA	NA
AZE96010.1\|4332620_4332797_-	hypothetical protein	NA	NA	NA	NA
AZE96011.1\|4333335_4333539_+	hypothetical protein	A0A2H4JE67	uncultured_Caudovirales_phage	1.3e-10	54.0
AZE96012.1\|4333568_4334048_+	Phage protein	A0A2H4JG61	uncultured_Caudovirales_phage	1.4e-42	54.3
AZE96013.1\|4334044_4334407_+	hypothetical protein	A0A2H4J947	uncultured_Caudovirales_phage	1.9e-07	45.5
AZE96014.1\|4334479_4334713_+	Adenylate kinase	NA	NA	NA	NA
AZE96015.1\|4334717_4337516_+	Phage protein	A0A2H4J936	uncultured_Caudovirales_phage	0.0e+00	65.5
4344278:4344294	attR	NA	NA	NA	NA

DBSCAN-SWA_7

4934185 : 5050548

118

Pseudomonas_phage(47.92%)

protease,terminase,tail,transposase,tRNA,capsid,portal,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZE96570.1\|4934185_4935073_+\|tRNA	Glutamyl-Q tRNA(Asp) synthetase	NA	NA	NA	NA
AZE96571.1\|4935135_4935312_+	hypothetical protein	NA	NA	NA	NA
AZE96572.1\|4935295_4938250_+	Two-component sensor CbrA: intrcellular carbon:nitrogen balance	NA	NA	NA	NA
AZE96573.1\|4938272_4939703_+	Two-component sensor CbrB: intrcellular carbon:nitrogen balance	NA	NA	NA	NA
AZE96574.1\|4940416_4941820_+	Poly(A) polymerase	G3MAR3	Bacillus_virus	1.8e-29	38.9
AZE96575.1\|4941822_4942308_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase	NA	NA	NA	NA
AZE96576.1\|4942432_4942639_-	hypothetical protein	NA	NA	NA	NA
AZE96577.1\|4942723_4943524_+	3-methyl-2-oxobutanoate hydroxymethyltransferase	NA	NA	NA	NA
AZE96578.1\|4943520_4944372_+	Pantoate--beta-alanine ligase	NA	NA	NA	NA
AZE96579.1\|4944597_4946262_+	Glucose-6-phosphate isomerase	NA	NA	NA	NA
AZE96580.1\|4946370_4947387_+	putative methyltransferase	W6LLI2	Streptococcus_phage	1.2e-14	28.1
AZE96581.1\|4947475_4950409_+	ClpB protein	NA	NA	NA	NA
AZE96582.1\|4950506_4950725_-	hypothetical protein	NA	NA	NA	NA
AZE96583.1\|4951128_4951749_-	Osmotically inducible protein Y precursor	NA	NA	NA	NA
AZE96584.1\|4952046_4954152_-	Polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
AZE96585.1\|4954346_4954616_-	SSU ribosomal protein S15p (S13e)	NA	NA	NA	NA
AZE96586.1\|4954732_4955650_-\|tRNA	tRNA pseudouridine(55) synthase	NA	NA	NA	NA
AZE96587.1\|4955653_4956049_-	Ribosome-binding factor A	NA	NA	NA	NA
AZE96588.1\|4956208_4958722_-	Translation initiation factor 2	A0A2H4UTS4	Bodo_saltans_virus	3.2e-21	23.5
AZE96589.1\|4958749_4960231_-	Transcription termination protein NusA	NA	NA	NA	NA
AZE96590.1\|4960278_4960737_-	Bacterial ribosome SSU maturation protein RimP	NA	NA	NA	NA
AZE96591.1\|4961545_4962301_-	Triosephosphate isomerase	NA	NA	NA	NA
AZE96592.1\|4962367_4963705_-	Phosphoglucosamine mutase	NA	NA	NA	NA
AZE96593.1\|4963721_4964573_-	Dihydropteroate synthase	NA	NA	NA	NA
AZE96594.1\|4964581_4966501_-	Cell division protein FtsH	I3UL75	Ostreococcus_lucimarinus_virus	6.5e-115	48.7
AZE96595.1\|4966692_4967343_-	23S rRNA (uridine(2552)-2'-O)-methyltransferase	NA	NA	NA	NA
AZE96596.1\|4967449_4967758_+	RNA-binding protein YhbY	NA	NA	NA	NA
AZE96597.1\|4967767_4968172_-	Permease of the major facilitator superfamily	NA	NA	NA	NA
AZE96598.1\|4968200_4968683_-	Transcription elongation factor GreA	NA	NA	NA	NA
AZE96599.1\|4968679_4971901_-	Carbamoyl-phosphate synthase large chain	NA	NA	NA	NA
AZE96600.1\|4972003_4973140_-	Carbamoyl-phosphate synthase small chain	R4TGJ8	Halovirus	2.4e-48	34.0
AZE96601.1\|4973398_4974205_-	4-hydroxy-tetrahydrodipicolinate reductase	NA	NA	NA	NA
AZE96602.1\|4974215_4975340_-	Chaperone protein DnaJ	A0A0P0YNN4	Yellowstone_lake_phycodnavirus	2.7e-28	32.1
AZE96603.1\|4975658_4977575_-	Chaperone protein DnaK	E5ESM6	Bathycoccus_sp._RCC1105_virus	2.4e-146	47.9
AZE96604.1\|4977677_4978238_-	Heat shock protein GrpE	NA	NA	NA	NA
AZE96605.1\|4978492_4980166_+	DNA repair protein RecN	NA	NA	NA	NA
AZE96606.1\|4980252_4980657_-	Ferric uptake regulation protein FUR	NA	NA	NA	NA
AZE96607.1\|4980755_4981283_+	Outer membrane beta-barrel assembly protein BamE	NA	NA	NA	NA
AZE96608.1\|4981342_4981546_-	protein YfjF	NA	NA	NA	NA
AZE96609.1\|4981634_4982069_-	Putative oligoketide cyclase/dehydratase or lipid transport protein YfjG	NA	NA	NA	NA
AZE96610.1\|4982238_4982721_+	tmRNA-binding protein SmpB	W5RAM5	Staphylococcus_phage	2.5e-23	41.3
AZE96611.1\|4982758_4983526_-	Lactate-responsive regulator LldR in Enterobacteria, GntR family	NA	NA	NA	NA
AZE96612.1\|4983564_4983777_-	hypothetical protein	NA	NA	NA	NA
AZE96613.1\|4983777_4985472_+	L-lactate permease	NA	NA	NA	NA
AZE96614.1\|4985542_4988353_+	putative D-lactate dehydrogenase, Fe-S protein, FAD/FMN-containing	NA	NA	NA	NA
AZE96615.1\|4988491_4988770_+	hypothetical protein	NA	NA	NA	NA
AZE96616.1\|4989378_4990131_+	hypothetical protein	NA	NA	NA	NA
AZE96617.1\|4990959_4991493_-	Phage endolysin	A0A059VA40	Pseudomonas_phage	2.8e-76	80.8
AZE96618.1\|4991549_4992104_-\|tail	tail fiber assembly domain protein	A0A2H4J9Z7	uncultured_Caudovirales_phage	8.7e-12	54.0
AZE96619.1\|4992104_4992878_-	hypothetical protein	K7PM99	Enterobacterial_phage	3.4e-14	30.6
AZE96620.1\|4992926_4993607_-	hypothetical protein	A0A059VF40	Pseudomonas_phage	1.8e-22	35.6
AZE96621.1\|4993947_4997970_-\|tail	Phage tail fiber protein	A0A2D1GNE3	Pseudomonas_phage	0.0e+00	66.2
AZE96622.1\|4998105_4998468_+	hypothetical protein	A0A2D1GNS8	Pseudomonas_phage	2.0e-09	45.6
AZE96623.1\|4998464_4999052_-	Phage protein	A0A2D1GNM2	Pseudomonas_phage	6.0e-88	82.9
AZE96624.1\|4999048_4999831_-\|tail	Phage tail assembly protein	A0A2D1GNP8	Pseudomonas_phage	7.9e-144	87.7
AZE96625.1\|4999833_5000538_-\|tail	Phage minor tail protein	A0A2D1GNF3	Pseudomonas_phage	1.1e-133	96.2
AZE96626.1\|5000587_5000938_-\|tail	Phage minor tail protein	A0A2D1GNJ1	Pseudomonas_phage	3.9e-58	89.6
AZE96627.1\|5000937_5004372_-\|tail	Phage tail length tape-measure protein 1	A0A2D1GNQ1	Pseudomonas_phage	4.9e-307	62.8
AZE96628.1\|5004427_5004946_-	hypothetical protein	NA	NA	NA	NA
AZE96629.1\|5004990_5005149_-	hypothetical protein	A0A2D1GNK2	Pseudomonas_phage	6.2e-16	84.3
AZE96630.1\|5005241_5005571_-	hypothetical protein	A0A2D1GNT5	Pseudomonas_phage	4.4e-48	91.7
AZE96631.1\|5005609_5006110_-	hypothetical protein	A0A2D1GNF2	Pseudomonas_phage	6.7e-80	90.9
AZE96632.1\|5006165_5006552_-	hypothetical protein	A0A2D1GNT4	Pseudomonas_phage	4.6e-60	92.2
AZE96633.1\|5006544_5007123_-	Phage protein, HK97, gp10	A0A2D1GNN2	Pseudomonas_phage	4.7e-61	63.5
AZE96634.1\|5007126_5007297_-	hypothetical protein	A0A2D1GNQ5	Pseudomonas_phage	2.1e-17	83.9
AZE96635.1\|5007306_5007639_-	hypothetical protein	A0A2D1GNG1	Pseudomonas_phage	2.4e-33	71.1
AZE96636.1\|5007638_5007938_-	hypothetical protein	A0A2H4J8C5	uncultured_Caudovirales_phage	3.9e-35	72.7
AZE96637.1\|5007938_5008139_-	hypothetical protein	NA	NA	NA	NA
AZE96638.1\|5008192_5009401_-\|capsid	Phage major capsid protein	A0A2H4J8D1	uncultured_Caudovirales_phage	6.4e-169	75.3
AZE96639.1\|5009397_5010003_-\|protease	GTA protease	A0A2H4JA51	uncultured_Caudovirales_phage	5.4e-84	77.4
AZE96640.1\|5010025_5011234_-\|portal	Phage portal protein	A0A2H4JFN7	uncultured_Caudovirales_phage	8.4e-177	75.2
AZE96641.1\|5011241_5012783_-\|terminase	Phage terminase, large subunit	Q9MCT1	Enterobacteria_phage	1.1e-194	68.0
AZE96642.1\|5012782_5013259_-	hypothetical protein	A0A0F7L441	uncultured_marine_virus	8.5e-32	51.0
AZE96643.1\|5013438_5013753_-\|holin	Phage holin	A0A286N2R3	Klebsiella_phage	5.4e-27	58.7
AZE96644.1\|5013752_5013914_-	hypothetical protein	NA	NA	NA	NA
AZE96645.1\|5013913_5014153_-	hypothetical protein	NA	NA	NA	NA
AZE96646.1\|5014155_5014386_-	hypothetical protein	NA	NA	NA	NA
AZE96647.1\|5014435_5014621_-	hypothetical protein	NA	NA	NA	NA
AZE96648.1\|5014592_5014970_-	Glutamate synthase [NADPH] large chain	NA	NA	NA	NA
AZE96649.1\|5014966_5015293_-\|holin	phage holin, lambda family	Q8SBE1	Shigella_phage	3.5e-13	41.1
AZE96650.1\|5015402_5015951_+	hypothetical protein	NA	NA	NA	NA
AZE96651.1\|5016103_5016955_-	hypothetical protein	NA	NA	NA	NA
AZE96652.1\|5017428_5017974_-	Phage protein	A0A1B0VMF2	Pseudomonas_phage	8.5e-12	26.9
AZE96653.1\|5017973_5018273_-	Phage protein	A0A1W6JTC1	Pseudomonas_phage	3.3e-18	52.9
AZE96654.1\|5018265_5018445_-	hypothetical protein	NA	NA	NA	NA
AZE96655.1\|5018441_5019815_-	Replicative DNA helicase (DnaB)	A0A2H4J8N1	uncultured_Caudovirales_phage	5.6e-169	65.2
AZE96656.1\|5019811_5020609_-	IstB domain protein ATP-binding protein	A0A1W6JTD8	Pseudomonas_phage	9.4e-68	55.6
AZE96657.1\|5020592_5021390_-	Primosomal protein I	A0A1W6JTD5	Pseudomonas_phage	4.7e-43	56.3
AZE96658.1\|5021386_5021623_-	Phage protein	NA	NA	NA	NA
AZE96659.1\|5021619_5022222_-	hypothetical protein	NA	NA	NA	NA
AZE96660.1\|5022218_5022953_-	putative phage-related protein	A0A2H4J111	uncultured_Caudovirales_phage	3.6e-21	65.1
AZE96661.1\|5022949_5023240_-	hypothetical protein	NA	NA	NA	NA
AZE96662.1\|5023236_5023629_-	hypothetical protein	NA	NA	NA	NA
AZE96663.1\|5023729_5024101_-	hypothetical protein	NA	NA	NA	NA
AZE96664.1\|5024872_5025601_+	Putative cI prophage repressor protein	F1C599	Cronobacter_phage	9.9e-56	50.8
AZE96665.1\|5025735_5026119_+	Phage protein	A0A1W6JTA9	Pseudomonas_phage	3.4e-31	64.7
AZE96666.1\|5026183_5026399_+	hypothetical protein	NA	NA	NA	NA
AZE96667.1\|5026401_5026836_+	hypothetical protein	A0A222YXQ0	Escherichia_phage	1.4e-25	43.1
AZE96668.1\|5026838_5027006_+	hypothetical protein	NA	NA	NA	NA
AZE96669.1\|5027061_5027487_+	Alginate biosynthesis transcriptional activator	A0A1W6JTB4	Pseudomonas_phage	4.3e-11	65.5
AZE96670.1\|5027474_5027744_+	hypothetical protein	A0A2H4J399	uncultured_Caudovirales_phage	6.7e-10	68.1
AZE96671.1\|5027740_5027908_+	hypothetical protein	NA	NA	NA	NA
AZE96672.1\|5028128_5029334_+\|transposase	putative transposase	A0A1W6JTA0	Pseudomonas_phage	3.5e-175	79.9
AZE96673.1\|5029359_5030478_+	RelA/SpoT domain protein	A0A1B0VBT5	Salmonella_phage	2.8e-33	32.0
AZE96674.1\|5030824_5030938_+	hypothetical protein	NA	NA	NA	NA
AZE96675.1\|5031189_5034654_+	Type I restriction-modification system, restriction subunit R	G9FI19	Nocardia_phage	7.9e-10	22.1
AZE96676.1\|5034749_5036261_+	hypothetical protein	NA	NA	NA	NA
AZE96677.1\|5036327_5037878_+	Type I restriction-modification system, DNA-methyltransferase subunit M	NA	NA	NA	NA
AZE96678.1\|5037870_5039289_+	Type I restriction-modification system, specificity subunit S	NA	NA	NA	NA
AZE96679.1\|5039315_5040251_+	Mrr restriction system protein	NA	NA	NA	NA
AZE96680.1\|5040772_5041039_+	hypothetical protein	NA	NA	NA	NA
AZE96681.1\|5041295_5042294_+	Cyclic pyranopterin phosphate synthase (MoaA)	NA	NA	NA	NA
AZE96682.1\|5042518_5043415_+	LysR family transcriptional regulator	NA	NA	NA	NA
AZE96683.1\|5043508_5044990_+	Melittin resistance protein PqaB	NA	NA	NA	NA
AZE96684.1\|5045005_5045494_-	putative membrane protein	NA	NA	NA	NA
AZE96685.1\|5045659_5047480_+	hypothetical protein	NA	NA	NA	NA
AZE96686.1\|5047487_5047805_-	hypothetical protein	NA	NA	NA	NA
AZE96687.1\|5048109_5050548_-\|protease	ATP-dependent protease La Type II	NA	NA	NA	NA

DBSCAN-SWA_8

5359228 : 5368500

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZE96981.1\|5359228_5361199_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	9.8e-74	38.5
AZE96982.1\|5361266_5363117_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	3.1e-37	34.5
AZE96983.1\|5363252_5366624_+	Sensory box/GGDEF family protein	A0A127AWB9	Bacillus_phage	1.1e-13	35.4
AZE96984.1\|5366896_5367319_-	Arsenate reductase	A0A2H4J8T1	uncultured_Caudovirales_phage	2.8e-71	94.3
AZE96985.1\|5367339_5368053_-	Arsenic resistance protein ArsH	A0A2H4J5V6	uncultured_Caudovirales_phage	9.4e-128	96.2
AZE96986.1\|5368143_5368500_-	Arsenical resistance operon repressor	A0A2H4J145	uncultured_Caudovirales_phage	2.5e-57	95.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP027725

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection