CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP018196	Fusobacterium necrophorum subsp. funduliforme strain F1291 chromosome, complete genome	3 crisprs	cas6,cas8b2,cas7,cas5,cas3,cas4,cas1,cas2,DEDDh,csa3,PD-DExK,cas13c,DinG,RT,WYL	4	5	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP018196_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP018196_1

547874-549232

TypeV

Consensus_repeat	Method
ATTAGAGTATTACTAGAGTAGAATGTAAAT	PILER-CR
ATTAGAGTATTACTAGAGTAGAATGTAAATT	CRISPRCasFinder
ATTAGAGTATTACTAGAGTAGAATGTAAAT	CRT

20 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,cas14j

The CRISPR arrays of CP018196_1

>merge|CP018196|1|547874-549232|PILER-CR,CRISPRCasFinder,CRT
ATTAGAGTATTACTAGAGTAGAATGTAAATCTGGATTATAGATTTAACAGGATGATGGATGGAAAAAATTAGAGTATTACTAGAGTAGAATGTAAATGCAGGAAGAATTCATCATATGATAGTCCATCAACATTAGAGTATTACTAGAGTAGAATGTAAATTTCCTTCGTGTCCGATGTTTGTATTTCGTCTTGAAGTTATTAGAGTATTACTAGAGTAGAATGTAAATTGATTTTTTGCTTGCAATCTAAAAAAATATTGTATAATTAGAGTATTACTAGAGTAGAATGTAAATGTCAAAAGAGAGAATAAGAAAGAAAAGAAGAAGCTATATTAGAGTATTACTAGAGTAGAATGTAAATAACTTTGAAACGGTTTTGAGTTCAATTTCTGAAAAAGATTAGAGTATTACTAGAGTAGAATGTAAATAATGTAAAAAAAGATTTTTACAAGCACGAGTATAGATTAGAGTATTACTAGAGTAGAATGTAAATTTTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAAATTAGAGTATTACTAGAGTAGAATGTAAATTTGCATCTGTCGAGGCGGCTAGAATTATGAAGCGTTATTAGAGTATTACTAGAGTAGAATGTAAATTCACATTCACAGTCGCTTGATTGACTGCTGTGGGCATTAGAGTATTACTAGAGTAGAATGTAAATTTTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAAATTAGAGTATTACTAGAGTAGAATGTAAATTCACATTCACAGTCGCTTGATTGACTGCTGTGGGCATTAGAGTATTACTAGAGTAGAATGTAAATTTTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAAATTAGAGTATTACTAGAGTAGAATGTAAATTCAATTTTTTCTTGATGGTTAGAGCAATACTTATAACCATTAGAGTATTACTAGAGTAGAATGTAAATTTTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAAATTAGAGTATTACTAGAGTAGAATGTAAATAACGTCCAAAGGCTTTCAAGCGTAGGACTTCTAAACAAATTAGAGTATTACTAGAGTAGAATGTAAATGAAGCAAGGAGACATACATAGACAAAGAAAAATATTTATTAGAGTATTACTAGAGTAGAATGTAAATTTTAAACTTCCAAACTTCTCTCCCTCATTTAACAAAATTAGAGTATTACTAAAGTAGAATGTAAATTTTAACATCCCAATACTTCTTCCGCCGTCTTGTAGAATTAGAGTATTACTAGAGTAGAATATAAATTTTCTTACTATCTGGAAACATGCTATTTTTTCAACAAATCAGAGTATTTTTAGAATTTATATTAAAAT

>CP018196|1|1|547874-549164|PILER-CR
ATTAGAGTATTACTAGAGTAGAATGTAAAT	CTGGATTATAGATTTAACAGGATGATGGATGGAAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	GCAGGAAGAATTCATCATATGATAGTCCATCAAC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTCCTTCGTGTCCGATGTTTGTATTTCGTCTTGAAGTT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TGATTTTTTGCTTGCAATCTAAAAAAATATTGTATA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	GTCAAAAGAGAGAATAAGAAAGAAAAGAAGAAGCTAT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	AACTTTGAAACGGTTTTGAGTTCAATTTCTGAAAAAG
ATTAGAGTATTACTAGAGTAGAATGTAAAT	AATGTAAAAAAAGATTTTTACAAGCACGAGTATAG
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTGCATCTGTCGAGGCGGCTAGAATTATGAAGCGTT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TCACATTCACAGTCGCTTGATTGACTGCTGTGGGC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TCACATTCACAGTCGCTTGATTGACTGCTGTGGGC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TCAATTTTTTCTTGATGGTTAGAGCAATACTTATAACC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	AACGTCCAAAGGCTTTCAAGCGTAGGACTTCTAAACAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	GAAGCAAGGAGACATACATAGACAAAGAAAAATATTT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTAAACTTCCAAACTTCTCTCCCTCATTTAACAAA
ATTAGAGTATTACTAAAGTAGAATGTAAAT	TTTAACATCCCAATACTTCTTCCGCCGTCTTGTAGA
ATTAGAGTATTACTAGAGTAGAATATAAAT

>CP018196|1|1|547874-549232|CRISPRCasFinder
ATTAGAGTATTACTAGAGTAGAATGTAAATC	TGGATTATAGATTTAACAGGATGATGGATGGAAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAATG	CAGGAAGAATTCATCATATGATAGTCCATCAAC
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TCCTTCGTGTCCGATGTTTGTATTTCGTCTTGAAGTT
ATTAGAGTATTACTAGAGTAGAATGTAAATT	GATTTTTTGCTTGCAATCTAAAAAAATATTGTATA
ATTAGAGTATTACTAGAGTAGAATGTAAATG	TCAAAAGAGAGAATAAGAAAGAAAAGAAGAAGCTAT
ATTAGAGTATTACTAGAGTAGAATGTAAATA	ACTTTGAAACGGTTTTGAGTTCAATTTCTGAAAAAG
ATTAGAGTATTACTAGAGTAGAATGTAAATA	ATGTAAAAAAAGATTTTTACAAGCACGAGTATAG
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TGCATCTGTCGAGGCGGCTAGAATTATGAAGCGTT
ATTAGAGTATTACTAGAGTAGAATGTAAATT	CACATTCACAGTCGCTTGATTGACTGCTGTGGGC
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAA
ATTAGAGTATTACTAGAGTAGAATGTAAATT	CACATTCACAGTCGCTTGATTGACTGCTGTGGGC
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAA
ATTAGAGTATTACTAGAGTAGAATGTAAATT	CAATTTTTTCTTGATGGTTAGAGCAATACTTATAACC
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAATA	ACGTCCAAAGGCTTTCAAGCGTAGGACTTCTAAACAA
ATTAGAGTATTACTAGAGTAGAATGTAAATG	AAGCAAGGAGACATACATAGACAAAGAAAAATATTT
ATTAGAGTATTACTAGAGTAGAATGTAAATT	TTAAACTTCCAAACTTCTCTCCCTCATTTAACAAA
ATTAGAGTATTACTAAAGTAGAATGTAAATT	TTAACATCCCAATACTTCTTCCGCCGTCTTGTAGA
ATTAGAGTATTACTAGAGTAGAATATAAATT	TTCTTACTATCTGGAAACATGCTATTTTTTCAACAA
ATCAGAGTATTTTTAGAATTTATATTAAAAT

>CP018196|1|1|547874-549231|CRT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	CTGGATTATAGATTTAACAGGATGATGGATGGAAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	GCAGGAAGAATTCATCATATGATAGTCCATCAAC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTCCTTCGTGTCCGATGTTTGTATTTCGTCTTGAAGTT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TGATTTTTTGCTTGCAATCTAAAAAAATATTGTATA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	GTCAAAAGAGAGAATAAGAAAGAAAAGAAGAAGCTAT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	AACTTTGAAACGGTTTTGAGTTCAATTTCTGAAAAAG
ATTAGAGTATTACTAGAGTAGAATGTAAAT	AATGTAAAAAAAGATTTTTACAAGCACGAGTATAG
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTGCATCTGTCGAGGCGGCTAGAATTATGAAGCGTT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TCACATTCACAGTCGCTTGATTGACTGCTGTGGGC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TCACATTCACAGTCGCTTGATTGACTGCTGTGGGC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTTTCCCTCTCTTGCAGCCATTCTTTGATTAGAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TCAATTTTTTCTTGATGGTTAGAGCAATACTTATAACC
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTTCCCTCCTAGATGTTTCTTTTCATTTTTTCAAAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	AACGTCCAAAGGCTTTCAAGCGTAGGACTTCTAAACAA
ATTAGAGTATTACTAGAGTAGAATGTAAAT	GAAGCAAGGAGACATACATAGACAAAGAAAAATATTT
ATTAGAGTATTACTAGAGTAGAATGTAAAT	TTTAAACTTCCAAACTTCTCTCCCTCATTTAACAAA
ATTAGAGTATTACTAAAGTAGAATGTAAAT	TTTAACATCCCAATACTTCTTCCGCCGTCTTGTAGA
ATTAGAGTATTACTAGAGTAGAATATAAAT	TTTCTTACTATCTGGAAACATGCTATTTTTTCAACAA
ATCAGAGTATTTTTAGAATTTATATTAAAA

Protein	Signature genes	Signature genes Name	Protein_function
CP018196.1\|AYV92658.1\|545893_546388_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
CP018196.1\|AYV92652.1\|538596_538998_-\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|376616
CP018196.1\|AYV92651.1\|537188_538586_-\|transposase	cas14j	-	unknown
CP018196.1\|AYV92657.1\|543671_545873_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
CP018196.1\|AYV92667.1\|557013_557730_+\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
CP018196.1\|AYV92663.1\|553107_554076_+\|thiamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270263
CP018196.1\|AYV92656.1\|542551_543661_+\|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|274218
CP018196.1\|AYV92666.1\|556088_557009_+\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
CP018196.1\|AYV92659.1\|546398_547391_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
CP018196.1\|AYV92655.1\|541656_542538_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
CP018196.1\|AYV92661.1\|549423_549666_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377122
CP018196.1\|AYV92653.1\|539462_540215_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
CP018196.1\|AYV92654.1\|540204_541635_+\|type-I-CRISPR-associated-protein-Cas8a1/Csx8	cas8b2	cd09697_cas8b2_CAS-I-B	gnl\|CDD\|274253
CP018196.1\|AYV92664.1\|554363_555269_+\|aspartate-carbamoyltransferase	unknown	unknown	gnl\|CDD\|223614
CP018196.1\|AYV92669.1\|558933_559557_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
CP018196.1\|AYV92665.1\|555278_556079_+\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|99814
CP018196.1\|AYV92668.1\|557723_558941_+\|dihydroorotase	unknown	unknown	gnl\|CDD\|223122
CP018196.1\|AYV92670.1\|559657_560560_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|376787
CP018196.1\|AYV92662.1\|550706_552419_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223097
CP018196.1\|AYV92660.1\|547397_547676_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|224262

Protein	Function_ID	Function_description	E-value
CP018196.1\|AYV92658.1\|545893_546388_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.18237e-61
CP018196.1\|AYV92652.1\|538596_538998_-\|IS200/IS605-family-transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	2.88098e-45
CP018196.1\|AYV92657.1\|543671_545873_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.29452e-68
CP018196.1\|AYV92667.1\|557013_557730_+\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	1.97211e-109
CP018196.1\|AYV92663.1\|553107_554076_+\|thiamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270263	cd13545, PBP2_TbpA, Substrate binding domain of thiamin transporter, a member of the type 2 periplasmic binding fold superfamily. Thiamin-binding protein TbpA is the periplasmic component of ABC-type transporter in E. coli, while the transmembrane permease and ATPase are ThiP and ThiQ, respectively. Thiamin (vitamin B1) is an essential confactor in all living systems that most prokaryotes, plants, and fungi can synthesized thiamin. However, in vertebrates, thiamine cannot be synthesized and must therefore be obtained through dietary absorption. In addition to thiamin biosynthesis, most organisms can import thiamin using specific transporters. After binding thiamine with high affinity, TbpA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The thiamine-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.64028e-72
CP018196.1\|AYV92656.1\|542551_543661_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|274218	TIGR02593, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5, N-terminal domain. This model represents a shared N-terminal domain, about 43 amino acids in length, common to a number of related protein families each of which is associated with a distinct subtype of CRISPR/cas system, where CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeat and Cas is an abbreviation for CRISPR-associated. Members of this family are widely distributed enough that we designated the family Cas5. Homology appears remote, or absent, between the more C-terminal regions different subfamilies of these proteins, which typically are 210 to 265 amino acids in total length. Cas5 proteins of six different CRISPR/cas subtypes so far defined are described by respective full-length models TIGR01868, TIGR01876, TIGR01895, TIGR01874, TIGR02586, and TIGR02592. The best characterized protein in this family is DevS or Myxococcus xanthus, a Cas protein that appears to participate in a species-specific developmental pathway.	1.10771e-07
CP018196.1\|AYV92666.1\|556088_557009_+\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	1.02554e-157
CP018196.1\|AYV92659.1\|546398_547391_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	8.50131e-169
CP018196.1\|AYV92655.1\|541656_542538_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	2.61934e-48
CP018196.1\|AYV92661.1\|549423_549666_+\|hypothetical-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	0.000172581
CP018196.1\|AYV92653.1\|539462_540215_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.67749e-15
CP018196.1\|AYV92654.1\|540204_541635_+\|type-I-CRISPR-associated-protein-Cas8a1/Csx8	gnl\|CDD\|274253	TIGR02670, Hypothetical_protein_FN1182, CRISPR-associated protein Cas8a1/Csx8, subtype I. In three genomes so far, a member of this protein appears in the midst of a CRISPR-associated (cas) gene operon, immediately upstream of a member of family TIGR01875 (CRISPR-associated autoregulator, DevR family). The genomes so far are Nocardia farcinica IFM10152, Clostridium perfringens SM101, and Clostridium tetani E88.	2.90968e-130
CP018196.1\|AYV92664.1\|554363_555269_+\|aspartate-carbamoyltransferase	gnl\|CDD\|223614	COG0540, PyrB, Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism].	3.38317e-142
CP018196.1\|AYV92669.1\|558933_559557_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	2.13879e-54
CP018196.1\|AYV92665.1\|555278_556079_+\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|99814	cd06218, DHOD_e_trans, FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.	1.67364e-96
CP018196.1\|AYV92668.1\|557723_558941_+\|dihydroorotase	gnl\|CDD\|223122	COG0044, PyrC, Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism].	2.68785e-131
CP018196.1\|AYV92670.1\|559657_560560_+\|quinolinate-synthase-NadA	gnl\|CDD\|376787	pfam02445, NadA, Quinolinate synthetase A protein. Quinolinate synthetase catalyzes the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid. This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein".	1.40453e-152
CP018196.1\|AYV92662.1\|550706_552419_+\|arginine--tRNA-ligase	gnl\|CDD\|223097	COG0018, ArgS, Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	0
CP018196.1\|AYV92660.1\|547397_547676_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|224262	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms].	9.62475e-29

>CP018196.1|AYV92660.1|547397_547676_+|CRISPR-associated-endonuclease-Cas2
MYVVVVYDISLDEKGTYHWKKIFQICKRYLHHIQNSVFEGELSEVDIERLKYEVSNYIRDNLDSFIIFKSRNERWMEKEMLGIQEDKTDNFL
>CP018196.1|AYV92659.1|546398_547391_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKRSYFLYSNGTLKRKDNTITFVNEKEEKKDIPIEMIGDFYIMSEMNFNTKFINYISQFGIPIHFFNYYTFYTGSFYPRETMVSGQLLVKQVEHYLNEEKRIEIAREFIEGASFNIYRNLRYYNGRGKDVSTYMHQIEELRKQLPNVTKVDELMGYEGNIRKIYYEAWNIIINQDIQFEKRVKNPPDNMINSLISFVNTLFYTKVLGEIYKTQLNSTVSYLHQPSTKRFSLSLDISEIFKPLIVDRLIFSLLNKKQITEKSFIKDFEYLRLKEDASKLIVQELEERLKQVIQHKDLNRKVSYQYLIRLECYKLIKHLLGEKKYLSFQMWW
>CP018196.1|AYV92658.1|545893_546388_+|CRISPR-associated-protein-Cas4
MKKEITGIMVYYYVVCQRKLWYFLHEIQMEADNSNVILGRLLEENTYTRDEKKIAIDGVINIDFFRAKKILHEIKKSKVMEEASILQVQYYLYYLEKKGLTGMKGILDYPLLKQKVEVELTEMDRKNLEKILSGIEKIMKSSVPPDLEKKSICKKCAYFDLCFV
>CP018196.1|AYV92657.1|543671_545873_+|CRISPR-associated-helicase/endonuclease-Cas3
MEYYAKPNKTIEEHNQDLQCARELLWKLGYIKSQEENKIVHEAIEHHDLGKKNEYFQRRVLSLKKKKFNPEMEVEHNVLSIYMINPKNYSKEEYESILYAVLFHHHYSDVVVTIDERKKDIARLLEGFSSYRLPMGFKIANLHTLKNQKLLGFLMKCDYAASGNYQIEYPNDFSEEKLERWRTSHSGFSWNPLQEFCYEYRMENIIAIADTGMGKTEAALRWIGNDKAFFTLPIRTAINAIYDRVSRDILHYENLEERLSLLHSSALEYYAKNLKDHELDIFDYHHRGKHLFLPLTICTADQIFNFVLKYKGYEMKLATLSYSKIVLDEIQMYDPNLLAAIILGMKTILELGGKIGIVTATFPPIVEYLMKKEIPDFSFQKEVFTSEDKIRHHVLTYEKRMGVDEITELFLKNRALGKSNKILVVCNTIKDAQKLYEHLLEKEELKEALFMLHSRFIKEDRAKKEKEILSFGKTDYIGEGIWISTQLVEASLDIDFDYLFTELQDLSSLFQRFGRCNRKGTKSVEEANCFVYLETEEGYLKEKDSSYGFIDKVLHTLSKEALIGYHGQISEKRKMKLVEEYLSYEKLENSSFLDEFEKAIKEYKNVLNVNKNEVSDLTRLRDIQNTTIIPFPVFQEYEEEIRELEEKLQKAEIPKEEKIHLREEMLKYTVEVPTYMLRDYEKALKSGNVDFMPVSPVKISQYDKIVILESLYDEMRGFQAKKFIEKNITFEFM
>CP018196.1|AYV92656.1|542551_543661_+|CRISPR-associated-protein-Cas5
MKALRIVLRQTSANYRKAGCLENKMTYPLPIPSTIIGALHNACGYTEYHPMDVSIQGKFSGLSKRAYTDYCFLNSVMDDRGILVKMANADCLSNSFVRVASSKKPQGNSFKKRISIQVHDEKLFEEYCRLKDISMEIKEQKDTVYKEKVAEFKQKKTELGNRKKKLEKNSEEYKRILEEEKKIKTEEKKYLDDFKEYEEKNYSIPIKAYRSLVTSLKFYEILHDIFLIIHIRAEEKILHDIHENIYELRSLGRSEDFVEVEDCNFIELQDFQEDIYSKETLNTSMYLNRRDVEEGKIFNLEVDLDHASGGTKYYLDKEYSIQENKRIFTKIPVLYSSHFGAQESSENVKLDFWGKDEEGNKIPVIVNFL
>CP018196.1|AYV92655.1|541656_542538_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKKNSLTLTVIANMTSNYSEGLGNISSVQKVYKNRAVYSIRSRESLKNALMVQSGMYEDLRTVVSGVTQKNVTPELNASNCRALEGGYMCTVADTYVRNSSFYLTDAISTESFVNETRFHNNLYLATNYAKANGLNVQVNAGTVGLMPYQYEYEKSPKVYSITIDLEKIGKDENFKQEAGAVEKYERVKCILEAVQNLSLVVKGNLDNAEPMFIIGGLSERKTHYFENVVKTEQGALILGEDLITKKKKGFRCALLRGDNFTNEEEILKTLQPISMEEFFDSLIREVKEYYQV
>CP018196.1|AYV92654.1|540204_541635_+|type-I-CRISPR-associated-protein-Cas8a1/Csx8
MKHSIDPKVYSGFDTAISASDWRYSAAIVGLQYYLEKMKKTYKIEKNIEIDKILDDFFLYHSQDITEKEYLQFVERFYGEELAHKALENKLNSKSTFHEEEVKWIKEKMAANTTLKKIFSKVKFIGENKQEILNLIEENRDFMIKETFRNKKNLYDNYCQSGVLLTEASKDSVCRVKGYYIDTGKKGKSMAYNFKTDTIVYEDDLIFDFIPFAFNGSSFETVFLNDNVDLELLIKMNYNVQVLWKRKEEERIEIPRNLMELLQSKTHQLKYGMEIIYKDREKTHFDSWYLRNESIEIFQKVNISKIQLNLKEGEIYRNILKETFKNIMNLSRVDDTIHFLLKEKEKKINTIGINLAIEELLEINNRIKNGGEKMTGNIKAAKACAREVVKEFKKKNIEKKLDSYRQKLISSLVFRDYKGTLDILMQLSNYSGVSFGFVFDFIENPSQNDDLVRAFVFKLNSTEYEPNGKEKKTEDK
>CP018196.1|AYV92653.1|539462_540215_+|CRISPR-associated-endoribonuclease-Cas6
MRFILKFSLHSTFLPIEIRRAVVSFIKKSLTEAHDAKYYEKFFKDTQLKDYCFSTIYSLEKFHSDCIELKKPEMSVVLSCTEKENIGFLLMNVFLLQRYKKFPLPNQNFMILQEIRPVKEKEIQGETALFRSTLGGGITVREHLQEENKDIYYSVGDENFLEKLDWIMKKRFERLGYPKDMIKFSSKLISGKKVIVKHFGLKFPVTNGIFEIQAPKVLLKEVYRTGLGSRLSQGLGLLEYLGPGGDINEA
>CP018196.1|AYV92652.1|538596_538998_-|IS200/IS605-family-transposase
MANINFGRGYVYSIQYHMVWCVKYRHEILVADIEKDLKEILRNISEELEIKIVEMETDKDHIHLLMECSPQHFIPRIIKILKGSSARKLFVKYPELKKRLWGGHLWNPSYFVATVSENIEEQIKKYIQTQKIK
>CP018196.1|AYV92651.1|537188_538586_-|transposase
MANYVLTLPLKTEKWQEDILDKRLNIARLLYNASLNEILKRYRKMQNDVEYKHMKHLDPKEQSKKYKEFDNKYGISKFDLNQYIKPMTQKFKKNIGSQMGQEIAERAYLAFEKLKYGKAKKVYFKRYGDFYSVREKGNKTGLRLFKEENCISWLGFKIPLIIRKNDSYAQKCFLDNLLFCKLLKKVIRGKNKYYVQITFEGVPPKKHEVRNHAEVGLDIGTSTIAIVSDKEVKLQILAENIGINEKEKTRLQRKLDRQRRANNPNKYNTDGTIKSNNKEKWKKSKSYLKTQLKFSDMQRKIAEKRKQSHTILANSILEIGTIVKVENMSFKGLQKRSKKNEISEKTGKFKKKKRFGKSLSNRAPALLIEIIDRKLRYIGKNIIKINTFKVKASQLNHETEEYEKKSLSKRWVEIVGNKIQRDLYSAFLIKNGKENLEEVDIEKAQKEFKNFVKLHNKEMERIKKK
>CP018196.1|AYV92661.1|549423_549666_+|hypothetical-protein
MLTTLDSLKQSEREINMEDMKKRFSNCTNDEIDKSSEITHVHSISKEACRIYVEIVKSLIINKNLKDILENLECTKNFQD
>CP018196.1|AYV92662.1|550706_552419_+|arginine--tRNA-ligase
MLLVNKELSKILTSTVEKLYADKEMKEVEIAPATNEKFGDFQCNFAMMNSKIIGKNPRMIAEEIQKNLVENEVIEKLEIAGPGFINIFLKEAYLSTFIKKIGKEKFDFSFLNRKGDVVIDFSSPNIAKRMHIGHLRSTIIGDSICRIYRYLGYHVIGDNHIGDWGTQFGKLIIGYRKWLDQDAYKKNAIEELERVYVKFSQESEEHPELEEEARLELKKLQDGDEENYNLWKEFIQVSMEEYEKLYSRLDIHFDTFYGESFYHPIMPEVVKELVERGIAKEDDGAKVVFFPEEENLFPCIVQKKDGAFLYATSDIATVKFRLHTYDVNRLIYLTDERQQDHFKQFFRITEMLGWNVEKYHVWFGIMRFADGVFSTRKGNVIRLEELLDEGKRRAYEIVQEKNPSLPEEEKQHIAEVVGVGAIKYADLSQNRQSPIIFEWDKILSFEGNTAPYLQYSYARVQSILDKAKNLGKEATEDVVLVLQDKYERSLANYMTIFPSSVLKAAETCKPNLIADYLYDLSKKLNSFYNNCPILNQEEEILKSRAYLAKQAGEVIKQGLNLLGIQTLDRM
>CP018196.1|AYV92663.1|553107_554076_+|thiamine-ABC-transporter-substrate-binding-protein
MKKIIAGSLLLLSSGVFAEEIVVYGPSTSKWIGKKYGPVFEKMTGDTIKYVSLDGVVQRLTLEKINPKADIVVGLTPVDIEVAKKHGVIQKYKPQNVEKIKKEIQYDKEYYAVPYDYGMLAINYDKTKIKNPPKNLEALGRMKKQLLIENPNTSNTGAEILQWSLALYGKNWKKFWTTIQPAIYNVEPGWEEAFAKFTAGEAPMMVGYATSDIWFAQDDSQKDRYASFYLEDGNYQYVESAALVAKKEVKAGAKKFMEAVLGEEFQTMTAAKNYMFPVTAVTLGKEFDSVPRTEKKVQFMANKEVVEHLANYKKEAVQILKK
>CP018196.1|AYV92664.1|554363_555269_+|aspartate-carbamoyltransferase
MRNFIFIQDLSRQDILDLLVLAKELKEKPEPDLLKGKIVATLFFEPSTRTRLSFTSAAYRIGANVLGFDSIQGTSVMKGESFEDTIRMVSSYSDVIVIRHPQDGTAQRAANISSVPVINAGDGKNEHPSQTLLDLYTIQEELGSLEEKKIAFVGDLKYGRTVHSLTGAMKHFRAKFYFVAPDSIQMPQYLLQELEEAGLEYSLHRHYEEILSEIDILYMTRIQKERFEDPKEFEKVESAYRIEKEDIVGRCQEHMIILHPLPRVDEIAVSVDECKHARYFQQAANGVPVREAMIALAVGKK
>CP018196.1|AYV92665.1|555278_556079_+|dihydroorotate-dehydrogenase-electron-transfer-subunit
MYLRDCIVRENSCIASSYYRMVIEIPEELLESKPGQFFMLKSLQDSFSLRRPISIHQLNKKERTMEFYYEVKGRGTKSLSMFKEGESISLQGPLGHGFSLVKKKKVLVLGGGMGIAPMKYLLDALKEENEVTFVAGGRNQEAIEILDSFSFQKLRAYITTDDGSVGMKGNVVMKLKELLESSSYDQIYVCGPHGMMLAAAEVAQEKEVSCEISLENRMACGVKACVGCSIQTVEGMKKVCHDGPVFDSKMIVNYEPKEKSTICCRN
>CP018196.1|AYV92666.1|556088_557009_+|dihydroorotate-dehydrogenase
MSCLETKFLGISMKNPLVTSSGCFGFGKEYQDYFDPNQLGGIVLKGITLEAREGNHGVRIAETPGGMLNCVGLENPGIDVFEREIIPNLRREGVTTSLIANINGKTMEEYMEIAKRVDNIEEVAMIELNISCPNVKDGGMAFGANPEVAGAVTREVRKITKKPLIVKLSPNVTDIAMIAKIVEENGADAVSLINTVLGMAIDVKSKKPLLGNTFGGMSGGAVKPIALRMIYQVYEAVTIPIVGMGGILNGTDALEFLMAGASLLSIGTGFFINPMVSVEVEKTLRDYCQQENIKNIQEIVGIAHRR
>CP018196.1|AYV92667.1|557013_557730_+|orotidine-5'-phosphate-decarboxylase
MDAREKIIIALDFPTEEKAIACVESLGEEAIFYKVGLELFLNSQGRILEYLREKQKKIFLDLKFHDIPNTTAMASVFAAKEEVAMFNVHASGGKKMMKKVMEETKKINEAASVIAVTVLTSFSEEDIQTLFQSKLSLQELAIHFASLAKEAGLSGVVCSPWEASEIKKACGERFQTVCPGVRPKWSANNDQERIMTPKEAVQHGCDYLVIGRPVTKHENPKEAMRLIVKEVKEGLQLC
>CP018196.1|AYV92668.1|557723_558941_+|dihydroorotase
MLVKNAKIIMGTEEIIVDILIQDGKFAKVGRNLSEHSEEEILDAKGHYVLPGIIDVHTHMRTPGFTQKEDVSSGSKAAIRGGVTSFFDMPNTNPATVTKEALEEKRKIYEGNSYADYAFYFGGTRFDNHVEVQKTVEETVATKIFLNVSTGDMLIEDDRILENIFRASNRVAVHAEEDMVAKAIQLARKTKKPLYLCHISLEKELEYIREAKEMGVEVYGEVTPHHLFLNEEDREQTEETKLFLRTKPELKTRKDNEALWKALQYGILDTIGTDHAPHLLEEKKAKLTFGMPSVEHSLEMMWKGVQEGKITVSRLQEVMCENPAKIFGLKKKGKIAVGYDADFVIVDETDHSEIQQEEIISKAAWSPYIKQKRGCKVLTTVLRGEIIYQEGKFGEKRGREILKYD
>CP018196.1|AYV92669.1|558933_559557_+|orotate-phosphoribosyltransferase
MTRKEAIAQVLLSTGAVKLNVKEPFTFVSGIKSPIYCDNRQMIAYPEEREVIIQGFQEALEGKEYDVLAGTATAGIPWAAFLAHSLQKPMSYIRGEKKSHGAGKQIEGVSVEGKRVIVIEDLISTGGSSIKAVEAAYAEGAVSVEVIAIFSYEFPKAYQQFGEKKIAWQSLSNFEVLIHKAEEMNYVTEEERNIAADWNQHADTWGK
>CP018196.1|AYV92670.1|559657_560560_+|quinolinate-synthase-NadA
MKEKIEKWKEETDSILLAHYYVPKEIQELADYVGDSFYLASLSKKVRQKQIVMAGVYFMGESIKILNPEKKVIMLHESADCPMAHMIQKEKIQEMREQYDDLAVVCYINSTAEIKALSDVCVTSSNAVSIVKQLSEKNIFFIPDGNLARYVASFVPEKNMIPNDGYCPVHHQITREELLEWKQKYPQAKIVSHPECQQDILSLSDFVGSTKQIIQKIKEYKGKEYIIVTEMGIAHELKRSSPDKKFYFLPSLSCQDMKYSTLEAFSKLLQNPLKEIILEKGTIEMAKKSLQRMLELGEGQ

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Crispr_ID: CP018196_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP018196_3

892277-893099

TypeVI-C

VI-C

Consensus_repeat	Method
GACTAAATCCAAGTAGATTGGAATTTTAAC	PILER-CR
GACTAAATCCAAGTAGATTGGAATTTTAAC	CRISPRCasFinder
GACTAAATCCAAGTAGATTGGAATTTTAAC	CRT

12 spacers

cas13c

The CRISPR arrays of CP018196_3

>merge|CP018196|3|892277-893099|PILER-CR,CRISPRCasFinder,CRT
GACTAAATCCAAGTAGATTGGAATTTTAACCCTTGTAAGATTGGTTTTATACTCATAAGAAAAGCGAGACTAAATCCAAGTAGATTGGAATTTTAACGCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAGGACTAAATCCAAGTAGATTGGAATTTTAACATTTCTTCTGATAATTCTTTCATAACATCAATTTTTGACTAAATCCAAGTAGATTGGAATTTTAACGCAACTCCTCTAACATCGCCCCTAATTTCACACGAGACTAAATCCAAGTAGATTGGAATTTTAACGAAAAATGGCTTATTTGCAATATAGAAGCATATTTGACTAAATCCAAGTAGATTGGAATTTTAACTATGGAATAACAGTGATCCGTTTTTAATTAATGATACGACTAAATCCAAGTAGATTGGAATTTTAACGCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAGGACTAAATCCAAGTAGATTGGAATTTTAACATTTCTTCTGATAATTCTTTCATAACATCAATTTTTGACTAAATCCAAGTAGATTGGAATTTTAACAACTCAGGAAATCAACGTCAGGAACTAAACGGAAAAGACTAAATCCAAGTAGATTGGAATTTTAACGCAACTCCTCTAACATCGCCCCTAATTTCACACGAGACTAAATCCAAGTAGATTGGAATTTTAACGAAAAATGGCTTATTTGCAATATAGAAGCATATTTGACTAAATCCAAGTAGATTGGAATTTTAACTTTTATAGTTTACATAACTATTATCTAAGTCACTAAAGACTAAATCCAAGTAGATTGGAATTTAATA

>CP018196|3|2|892277-893032|PILER-CR
GACTAAATCCAAGTAGATTGGAATTTTAAC	CCTTGTAAGATTGGTTTTATACTCATAAGAAAAGCGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAG
GACTAAATCCAAGTAGATTGGAATTTTAAC	ATTTCTTCTGATAATTCTTTCATAACATCAATTTTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAACTCCTCTAACATCGCCCCTAATTTCACACGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GAAAAATGGCTTATTTGCAATATAGAAGCATATTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	TATGGAATAACAGTGATCCGTTTTTAATTAATGATAC
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAG
GACTAAATCCAAGTAGATTGGAATTTTAAC	ATTTCTTCTGATAATTCTTTCATAACATCAATTTTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	AACTCAGGAAATCAACGTCAGGAACTAAACGGAAAA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAACTCCTCTAACATCGCCCCTAATTTCACACGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GAAAAATGGCTTATTTGCAATATAGAAGCATATTT
GACTAAATCCAAGTAGATTGGAATTTTAAC

>CP018196|3|3|892277-893099|CRISPRCasFinder
GACTAAATCCAAGTAGATTGGAATTTTAAC	CCTTGTAAGATTGGTTTTATACTCATAAGAAAAGCGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAG
GACTAAATCCAAGTAGATTGGAATTTTAAC	ATTTCTTCTGATAATTCTTTCATAACATCAATTTTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAACTCCTCTAACATCGCCCCTAATTTCACACGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GAAAAATGGCTTATTTGCAATATAGAAGCATATTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	TATGGAATAACAGTGATCCGTTTTTAATTAATGATAC
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAG
GACTAAATCCAAGTAGATTGGAATTTTAAC	ATTTCTTCTGATAATTCTTTCATAACATCAATTTTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	AACTCAGGAAATCAACGTCAGGAACTAAACGGAAAA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAACTCCTCTAACATCGCCCCTAATTTCACACGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GAAAAATGGCTTATTTGCAATATAGAAGCATATTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	TTTTATAGTTTACATAACTATTATCTAAGTCACTAAA
GACTAAATCCAAGTAGATTGGAATTTAATA

>CP018196|3|2|892277-893099|CRT
GACTAAATCCAAGTAGATTGGAATTTTAAC	CCTTGTAAGATTGGTTTTATACTCATAAGAAAAGCGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAG
GACTAAATCCAAGTAGATTGGAATTTTAAC	ATTTCTTCTGATAATTCTTTCATAACATCAATTTTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAACTCCTCTAACATCGCCCCTAATTTCACACGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GAAAAATGGCTTATTTGCAATATAGAAGCATATTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	TATGGAATAACAGTGATCCGTTTTTAATTAATGATAC
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAGACCAAGCAACTGAAAAAATTGGTTTTTTTACAG
GACTAAATCCAAGTAGATTGGAATTTTAAC	ATTTCTTCTGATAATTCTTTCATAACATCAATTTTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	AACTCAGGAAATCAACGTCAGGAACTAAACGGAAAA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GCAACTCCTCTAACATCGCCCCTAATTTCACACGA
GACTAAATCCAAGTAGATTGGAATTTTAAC	GAAAAATGGCTTATTTGCAATATAGAAGCATATTT
GACTAAATCCAAGTAGATTGGAATTTTAAC	TTTTATAGTTTACATAACTATTATCTAAGTCACTAAA
GACTAAATCCAAGTAGATTGGAATTTAATA

Protein	Signature genes	Signature genes Name	Protein_function
CP018196.1\|AYV92943.1\|875988_876645_+\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|234579
CP018196.1\|AYV92953.1\|895810_896407_+\|DUF1819-family-protein	unknown	unknown	gnl\|CDD\|378066
CP018196.1\|AYV92950.1\|885011_888653_+\|BREX-1-system-adenine-specific-DNA-methyltransferase-PglX	unknown	unknown	gnl\|CDD\|380294
CP018196.1\|AYV92949.1\|881205_884928_+\|BREX-system-P-loop-protein-BrxC	unknown	unknown	gnl\|CDD\|380283
CP018196.1\|AYV92959.1\|904876_906211_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|223694
CP018196.1\|AYV94059.1\|902736_904860_+\|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|236995
CP018196.1\|AYV94060.1\|901280_902681_+\|galactose-mutarotase	unknown	unknown	gnl\|CDD\|185696
CP018196.1\|AYV92956.1\|897638_897887_-\|hypothetical-protein	unknown	unknown	unknown
CP018196.1\|AYV92957.1\|898158_900399_+\|serine-protease	unknown	unknown	gnl\|CDD\|224666
CP018196.1\|AYV92954.1\|896427_896985_+\|DUF1788-domain-containing-protein	unknown	unknown	gnl\|CDD\|378040
CP018196.1\|AYV92955.1\|897071_897620_-\|DJ-1-family-protein	unknown	unknown	gnl\|CDD\|153229
CP018196.1\|AYV92947.1\|879939_880518_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
CP018196.1\|AYV92945.1\|877859_878564_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|223298
CP018196.1\|AYV92951.1\|888676_892090_+\|hypothetical-protein	cas13c	cas13c_CAS-VI-C	unknown
CP018196.1\|AYV92952.1\|893281_895792_+\|BREX-1-system-phosphatase-PglZ-type-A	unknown	unknown	gnl\|CDD\|274259
CP018196.1\|AYV92944.1\|876654_877884_+\|3-deoxy-D-manno-octulosonic-acid-transferase	unknown	unknown	gnl\|CDD\|224436
CP018196.1\|AYV92948.1\|880514_881075_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
CP018196.1\|AYV92958.1\|900401_901193_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182593
CP018196.1\|AYV92942.1\|875050_875980_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|225173
CP018196.1\|AYV92946.1\|878575_879853_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904

Protein	Function_ID	Function_description	E-value
CP018196.1\|AYV92943.1\|875988_876645_+\|(d)CMP-kinase	gnl\|CDD\|234579	PRK00023, cmk, (d)CMP kinase.	2.86602e-107
CP018196.1\|AYV92953.1\|895810_896407_+\|DUF1819-family-protein	gnl\|CDD\|378066	pfam08849, DUF1819, Putative inner membrane protein (DUF1819). These proteins are functionally uncharacterized. Several are annotated as putative inner membrane proteins.	1.25845e-32
CP018196.1\|AYV92950.1\|885011_888653_+\|BREX-1-system-adenine-specific-DNA-methyltransferase-PglX	gnl\|CDD\|380294	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX. This protein, PglX, is a site-specific DNA methyltransferase associated BREX (bacteriophage exclusion) type 1 systems. The phage resistance appears not to be through restriction-modification, as phage DNA appears not to get degraded, but it does manage to inhibit phage replication.	0
CP018196.1\|AYV92949.1\|881205_884928_+\|BREX-system-P-loop-protein-BrxC	gnl\|CDD\|380283	NF033441, BREX_BrxC, BREX system P-loop protein BrxC. BrxC is a P-loop-containing protein, and probable ATPase, from BREX (bacteriophage exclusion) systems of type 1.	0
CP018196.1\|AYV92959.1\|904876_906211_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	2.04535e-163
CP018196.1\|AYV94060.1\|901280_902681_+\|galactose-mutarotase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	7.60393e-111
CP018196.1\|AYV92957.1\|898158_900399_+\|serine-protease	gnl\|CDD\|224666	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only].	1.89267e-52
CP018196.1\|AYV92954.1\|896427_896985_+\|DUF1788-domain-containing-protein	gnl\|CDD\|378040	pfam08747, DUF1788, Domain of unknown function (DUF1788). Putative uncharacterized domain in proteins of length around 200 amino acids.	2.64096e-39
CP018196.1\|AYV92955.1\|897071_897620_-\|DJ-1-family-protein	gnl\|CDD\|153229	cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1. DJ-1 is involved in multiple physiological processes including cancer, Parkinson's disease and male fertility. It is unclear how DJ-1 functions in these. DJ-1 has been shown to possess chaperone activity. DJ-1 is preferentially expressed in the testis and moderately in other tissues; it is induced together with genes involved in oxidative stress response. The Drosophila homologue (DJ-1A) plays an essential role in oxidative stress response and neuronal maintenance. Inhibition of DJ-1A function through RNAi, results in the cellular accumulation of reactive oxygen species, organismal hypersensitivity to oxidative stress, and dysfunction and degeneration of dopaminergic and photoreceptor neurons. DJ-1 has lacks enzymatic activity and the catalytic triad of typical GATase1 domains, however it does contain the highly conserved cysteine located at the nucelophile elbow region typical of these domains. This cysteine been proposed to be a site of regulation of DJ-1 activity by oxidation. DJ-1 is a dimeric enzyme.	5.62595e-48
CP018196.1\|AYV92947.1\|879939_880518_+\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	4.55617e-42
CP018196.1\|AYV92945.1\|877859_878564_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|223298	COG0220, COG0220, Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only].	2.12889e-46
CP018196.1\|AYV94059.1\|902736_904860_+\|polyribonucleotide-nucleotidyltransferase	gnl\|CDD\|236995	PRK11824, PRK11824, polynucleotide phosphorylase/polyadenylase; Provisional.	0
CP018196.1\|AYV92952.1\|893281_895792_+\|BREX-1-system-phosphatase-PglZ-type-A	gnl\|CDD\|274259	TIGR02687, conserved_hypothetical_protein, TIGR02687 family protein. Members of this family are uncharacterized proteins sporadically distributed in bacteria and archaea, about 880 amino acids in length. This protein is repeatedly found upstream of another uncharacterized protein of about 470 amino acids in length, modeled by TIGR02688.	1.4442e-122
CP018196.1\|AYV92944.1\|876654_877884_+\|3-deoxy-D-manno-octulosonic-acid-transferase	gnl\|CDD\|224436	COG1519, KdtA, 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane].	8.9707e-114
CP018196.1\|AYV92948.1\|880514_881075_+\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	2.03571e-35
CP018196.1\|AYV92958.1\|900401_901193_-\|hypothetical-protein	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.48231e-38
CP018196.1\|AYV92942.1\|875050_875980_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|225173	COG2264, PrmA, Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis].	6.43732e-95
CP018196.1\|AYV92946.1\|878575_879853_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0

>CP018196.1|AYV92951.1|888676_892090_+|hypothetical-protein
MEKFRRQNRNSIIKIIISNYDTKGIKELKVRYRKQAQLDTFIIKTEIVNNDIFIKSIIEKAREKYRYSFLFDGEEKYHFKNKSSVEIVKKDIFSQTPDNMIRNYKITLKISEKNPRVVEAEIEDLMNSTILKDGRRSARREKSMTERKLIEEKVAKNYSLLANCPMEEVDSIKIYKIKRFLTYRSNMLLYFASINSFLCEGIKGKDNETEEIWHLKDNDVRKEKVRENFKNKLIQSTENYNSSLKNQIEEKEKLLRKEFKKGAFYRTIIKKLQQERIKELSEKSLTEDCEKIIKLYSKLRHSLMHYDYQYFENLFENKKNDDLMKDLNLDLFKSLPLIRKMKLNNKVNYLEDGDTLFVLQKTKKAKTLYQIYDALCEQKNGFNKFINDFFVSDGEENTVFKQIINEKFQSEMEFLEKRISESEKKNEKLKKKLDSMKAHFRNINSEDTKEAYFWDIHSSRNYKTKYNERKNLVNEYTELLGSSKEKKLLREEITKINRQLLKLKQEMEEITKKNSLFRLEYKMKIAFGFLFCEFDGNISKFKDEFDASNQEKIIQYHKNGEKYLTSFLKEEEKEKFNLEKMQKIIQKTEEEDWLLPETKNNLFKFYLLTYLLLPYELKGDFLGFVKKHYYDIKNVDFIDENQNNIQVSQTVEKQEDYFYHKIRLFEKNTKKYEIVKYSIVPNEKLKQYFEDLGIDIKYLTGSVESGEKWLGENLGIDIKYLTVEQKSEVSEEKNKKVSLKNNGMFNKTILLFVFKYYQIAFKLFNDIELYSLFFLREKSGKPLEIFRKELESKMKDGYLNFGQLLYVVYEVLVKNKDLDKILSKKIDYRKDKSFSPEIAYLRNFLSHLNYSKFLDNFMKINTNKSDENKEVLIPSIKIQKMIQFIEKCNLQNQIDFDFNFVNDFYMRKEKMFFIQLKQIFPDINSTEKQKMNEKEEILRNRYHLTDKKNEQIKDEHEAQSQLYEKILSLQKIYSSDKNNFYGRLKEEKLLFLEKQGKKKLSMEEIKDKIAGDISDLLGILKKEITRDIKDKLTEKFRYCEEKLLNLSFYNHQDKKKEESIRVFLIRDKNSDNFKFESILDDGSNKIFISKNGKEITIQCCDKVLETLIIEKNTLKISSNGKIISLIPHYSYSIDVKY
>CP018196.1|AYV92950.1|885011_888653_+|BREX-1-system-adenine-specific-DNA-methyltransferase-PglX
MNKSNLKKFAIEARQELREKTKAQLKRLGIEEKKIEEGKDMGSQVEIYGKLYSKSSYQHLLVKYHSLGYEELVEESAYLWFNRLTALAYMELHDCFTEHMIFSKGNKGEPDILDEYFQADFFQKMPLEKQEELHQLRDKNTSDSLETLYSILMEEKCEELSKIMPFLFSKKGKYADILFPSGLLMQDSVLKKLQVILLEIQEEDQSIPVEILGWLYQYYNSERREVVYDGSMKKSKIKREFIPAATQLFTPDWIVRYIVDNTVGRLAEEQFSISKDIIKKWQYYIAPEIVSKNEKMQIESLKILDPAMGSGHMLTYAFDILFDVYQELGWSKKESVLSILQNNLYGLEIDDRAGQLAAFALLMKGKEKFPRLFQVLEREENFEMPVISLQESNAISKRMYTMLEECPTLQDLLKGFEDTKEYGSILKIDSFEESILQEEYHKLQEKIQNQGQFSLLNNNEFLEGDLEEDLERLEHIIRQYKIMIQKYDVVITNPPYMGNARMNPKLKTYIEKYYPNVKTDLFSVFFIKCCEMTTEKGYLGFMSPFVWMFIKSYEELRTLFIHSKTIISLVQLEYSGFEDATVPICTFILQNTVIKKIGEYIKLSDFKGVKNQPIKTLEAIQNENCTWRYQANQKDFTKIPGSPIAYWVSDRIREIFEKEKKLGEVGDAKVGLQTGDNNKFVRLWHEINFNKIGFGMQNSEEALKSKKKWFPYNKGGEKRKWYGNQEYVVNWERDGYEIKHFCDTNGKLRSRPQNTEYYFKKSISWGLITSSGSSFRFYPEGFIYDVSGMSYFIEDKFLTYLGILNTKIYSKLTKLINPTINLQIGDILNLPVANIQNPLFEQLVSLILWISFEEWASRETSWDFERLTLLNGENLSKAYKKYCTYWESKFFSVHSSEEDLNRILLESYSLQEEMDEKVDFSDITLLKKEASIVENTDSAASCGYLENRGVRLEFHSLELVKQFLSYAIGCIMGRYSLDKPGLIMANSDDVLTMSSNKITVSGVNGAIRHEILNPSFFPEEFGILSVTTEERFENDVVSRVIAFISAAYGKEHLAENLEFITEVLGKKAGESHEEVLRNYFIKDFYTDHCQRYQKRPIYWMLHSGKKNGFSALIYLHRYEKDTIARMRSDYLLPYQEFMEQQEAHYSKIASDEISTPKEKKDAQKKVKELHDILKELKDYANKVKHIAEQRISLDLDDGVKVNYEKLGSILKKI
>CP018196.1|AYV92949.1|881205_884928_+|BREX-system-P-loop-protein-BrxC
MKNCLIQSTFQKDITRKINGVIKADSKEEDVIVTELSEYVVTEEIQKYLNIFFNRYVDSLQSPTEDIGVWISGFFGSGKSHFLKMIGRILENKEYQGKKVIDFFEEKIQDAILQKNIEKAAEVPTDVILFNIDNVSDQNTQQNKDTIPIAFLKKFNEYLGFSRDNIKIADFERMLWEKGKFEIFQKTFAEISGKIWKEEYRNLDFDADDFLDTIEKLEIMSREAAIRWLEKESDISISAESLADLLEQYLKKQSKEHRIVFLVDEIGQYIGENSQLMLNLQTLVETLGVKFKGRIWVGVTSQQDLGNILGKARERSNDFSKIQDRFKTMLPLSSANIDEVIKKRLLEKKQLQQEELESLYDKTRIYIENAITFDKTGMTLALFEDRKDFAESYPFVGYQFNLLQKVFEKVRNMGYSGQHMSRGERSLLSSFQEAGIRVKDMEVGSLVPFQYFYQSIEQFLEDNVRRPFIHAKNERGIDEFGLEVLKLLFLLKGIKGITPNINNLVSFMVDSVDCDRLALEEKIKKALGKLEQQVLIQKDGEGYYFLTNEEQDINKEINQELINEQDVYKELNTYIFGQIFTSPTVTMEDTKNKYNFSQKIDEIPFGKIGGQLDILILTPRSDEYDNIAILGYRDGYDLILRLPEEMTYWKEIQQSLRIASYVQKTLRGSIREVVHQILQMKQQENSKRKQRIQSEVERMLSEAEIYIQGQKVNITTTQADKRIAEALKAVARHRFNKAKLIQKPYYESEIRNVLSYEYDAGTNLFDIKKDMSTNPNYEALQEILTYITLHTSRGNVITLKHIVEYFSKKPYGWEIFSIHGLVAELWIYKQIQIEESKNPIHNAEELKILLVKSQSKTEERLVISLREEIDTELLQKVNNLLKKLFGPEKEVSVDQPKKDILEILKKKIDLPKMYSRECESGVYPGKKELQEWIDLLEEILFSKEKTEKLLKHFLEMEEELLEAYDNQGVVLDFFRSSKKKKFDEGLEKRKKIKEYEAVIGSIQETKPYQDLVDILTNKSPYNQIKHIDALLEEIQVEEEKLILEEKNMLLQRIEEKAKEFSILFQERDAMLEKTIEKLKAFKNKIEKTDDLSIFFSLSDWNKVLSSIEMEYRKNIQEELRSFEKAAFEVTEDKTDVKELVEDIRNTFHAYQEEAKSNDVDQLEQLIQKAKKDQEGFILQGNGRAKKKERVQFRKIRVAEKSNIETIEAVEEYISKLENEIQSLKEKMLQAIRENKIVDIQ
>CP018196.1|AYV92948.1|880514_881075_+|chromate-transporter
MIYINLVIGFLKVGCFAFGGAYGAIPLIREIVLSYAWLTEEELTYMIAVSESTPGPIMVNLATYIGSSQAGFWGAVLSTIAVILPSFFMVLLLMIVLKNMLENKYVRAILRGVKPCMIGIIFATGMYMILTNTGLHGEKKLDIRALLLVLFLFLLSFLPQKIVGKKLSSMNLIMLSAVFGIVFYGF
>CP018196.1|AYV92947.1|879939_880518_+|chromate-transporter
MKLLLELFITFCKIGFFTFGGGYAMISFIEENCIEKKKWISHEDMMNVTVIAESTPGPIAINCATFIGYKQAGLIGAVISTLGMVFPSFIVIFIISIFFDNFLKIQWIAHALKGIKIYVGILILNAAVTMLKKMPKNKLSRGIVFCAAMMMLLIFLFSLRISSVLLMLFFGVFSLVFMLITENKRGKRGDKK
>CP018196.1|AYV92946.1|878575_879853_+|adenylosuccinate-synthase
MAGYVVVGTQWGDEGKGKIIDVLADRADYVVRFQGGNNAGHTVVVNGEKFILKLLPSGVLHGGTCVIGPGVVVDPKVLLEELASLETRGAKTDHVIISDRAQVIMPYHVKLDELREAKEGGLKIGTTKKGIGPCYEDKISRYGIRMADLLDMPQFEEKLKRNLAMKNEIFTKIYGVEPLDYDKILADYKGYIEKIKHRIKDTIPIVNKALDENKLVLFEGAQAMMLDINYGTYPYVTSSSPTTGGVTTGAGVSPRKIDKGIGVMKAYTTRVGEGPFVTELLGEFGEKVRQIGGEYGAVTGRPRRCGWLDLVVGRYATMINGLTDIVITKIDVLSGLGKLKICTAYEIDGERYESVPANTDLLYRAKPIYEELDGWDEDITKVQKYEDLPENCKKYLKRIEEIVKCKISVVSVGPDRTQNIHIHEI
>CP018196.1|AYV92945.1|877859_878564_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MEHKEKEIEELWSYFFKKPRNNYNPYMLRLLDFPDYILFKKKMMNDYKGKWKEFFKNENPIYLEIGTGSGNFTKEIAKRHPERNFIGLELRFKRLCLAASKCQKESLNNVVFLRRRGEELSEFLGKEELSGLYINFPDPWEGNEKNRMIQEKLFSSLDSILKVGGVLFFKTDHDQYYQDVLALVGSLEHYQVIYHTSDLHQSEKAENNIKTEFEHLFLYKHNKNINYIEIQKVK
>CP018196.1|AYV92944.1|876654_877884_+|3-deoxy-D-manno-octulosonic-acid-transferase
MYSRCHRFLLTMISILGSRKQKEFIRSRLLQNYNALSKNIHIWIHASSVGEVNLLEQFLQTCLENFEGDILLTVFTDTGRETSLQKYGKEERVHILYFPLDDKTSIQKILDKISLQNLYLIETELWPNLITFCHQEARVVVVNGRISGKSFRRYQKIKFLLKAVLQKIESFYVQTEEDKKRYISLGAKKEDCYTVGNLKFDIPMPSYSEEEREAYRREFCLQAHRVWVAGSTRTGEYDILLDAFQKLKNYRLVLVPRHLERVPEVETVLQERKISYQKYSDFKREEEFSVLLVDRMGVLRKLYSIADVTFVGATLVDIGGHSLLEPLSYEKTPIFGPYTQNVKEIAKTVLERGIGYQVRNSEEIVEAIDKIEKQSQSIREEVRNFLQENKEVGKKILEREAQWNIKKKK
>CP018196.1|AYV92943.1|875988_876645_+|(d)CMP-kinase
MKEFIVALDGPAGSGKSTIAKEIAKQYHFTYVDTGAMYRMITWFFLEHSIAWNKEEVCRKALQGVRLDMKEETFFVNGQDVSEEIRGPKVSSHVSEIAALKAVREQLVYLQREIAKGKEVILDGRDIGTVVFPEANVKIFLLASAEERAKRRFLEYQAKGERISYEEVLQSIQERDHIDSTRKESPLRKAEDAIEIDSSTMSIDEVVARVSKEIDQKR
>CP018196.1|AYV92942.1|875050_875980_+|50S-ribosomal-protein-L11-methyltransferase
MKVVEVKVIFESDEIQKYQKQICDIFYEFGVTGLQIEEPLEKKHPLDYYREESSFLMRNHSVSAYFPMNFYAKKRQETLIQVFEEKFGQDEEVVYSIDFYEHEEEDYQNSWKKYLYPEKISSQFVVKPTWREYEAAEGEKVIELDPGRAFGTGSHPTTSLCVDLMEEKIKVGETVLDVGTGSGILMIVAEKLGARFVCGVDIDELAVEVAHENLELNAVPKEKYEVLHGNLIEKIETKSYDVVVANILADVLLLLLKDISSVVKTGGKIIFSGIIEDKVNEVIAAVEGAGMKVEKVLAKGEWRALAIRA
>CP018196.1|AYV92952.1|893281_895792_+|BREX-1-system-phosphatase-PglZ-type-A
MEKEKIKEMLEERFQVIPAYPRKRHILFWYDGQKAFQDIIEELQLDKVKILRLQKGVNRNGEEIDTNLFKIKYTLEILDTDSHYLIYSANPRPSKHENYLLDIESYSDFFEADKSAILVDDFGFDRKNHGIHDTIREYSEFFASKERREKLRKLLENPLHTSEEKLKLSVLAVIVGAKTAELQEILKNIIFDSSKLEQIKKWMGLSFLYEQILRKFHLSIESWEEFLKILVVVHFYREVQQKPSIHLESYYLGKTNELFIFTSSLFQNQNDSKHIQEIFYEVGKELNMKDRIEELEFEKMLLGNSFEYFEKRILQELVDRLQLGVVDYSQYISWIQERSHYSFWKEKYFYFYETLLSVAHLLKEKEQLEIQDRKTLSKILEDYTAHYYKIDQAYRNFYYSYDQIKSSELASIFDSFHSKISHFYEVEYLEVLLALWNEHLEERNSLAQQKDFYERYIKNSNTRVAVIISDALRYEVGEEITRQLEKEGNAKEIRIFPLLTNLPSITSVGMTQLLPPGKDRSIDLFHNKMTVNGISTFSTENREKILKESCLESSAISYDTFKNKSRGEQEAYVKGKKVLYFYHDSIDAIGDKAKTEHRTFDACKMAMQDILSLTKILSSLGIVNIFISSDHGFLYERKEIEEYNKLELQEEYFLLGKRYAFSTKKVEEKGCITIPIEDFFGVFPQKNQRIKVGGSGLQFVHGGSSPQEMIIPCIHYRGGAKVKKAKKVGVRIKEMGEKITSHFRKFAIYQLEPVNPQEKLLERTVVAALYDGNICISNEFKILLCAETENTEYSFSLTLSGEHEKVILRVTDAESKDILDQKEYQVKIGIASEFDF
>CP018196.1|AYV92953.1|895810_896407_+|DUF1819-family-protein
MLMKYRAITGENFYVQELKNACQFLLQHPELENKRQAFQERDILNCVSESNFNKKFQTIQKRLQVFTPKLMELFLKVDYTTTKFINLYAILSQERFFAEFMDEVIKEKYFLLDFELTNYDFYEFMERKKEQSEIIQQWSDAGCHKMIHKLKNFLVEANFLEKSPSGELYLIKRPLVDMAVIEEIEKHGNAKILKLMLY
>CP018196.1|AYV92954.1|896427_896985_+|DUF1788-domain-containing-protein
MKELDIRFQNLIQKVKSDEFYYNKGLANEVPFYIFDYNPKEELEVREYIHSLFLPEIQKEDRLQVVEIDMFELLLESMKNDNILEKAFLMEEQKGTQFLYEKLKKSFNVEVILRYISQKSKGKNFMILTGVGKVFPIVRTHTILNNLQNILEDTKVLLFFPGEYTSTDLRLFGFEDNNYYRAFRI
>CP018196.1|AYV92955.1|897071_897620_-|DJ-1-family-protein
MKKVFVLLANGFELIEAMTPVDVLRRCGAEVNTVSTGEDLWLNSSNGVTLKADIYWEEADFEQGDILILPGGYPGYVHLRENRLVVSQVKNYLSQGKYVAAICGAPSLFSEHELALHYRLTGHSSIQEDLKKQHDYTGENTTIDRNLITGIGAGHSLEFSFQIASLLFEKEIVEKVKEGMEL
>CP018196.1|AYV92956.1|897638_897887_-|hypothetical-protein
MFEDWQDNLYDSTFDSIFNALIAEYKEGKLDVEELKVNIAEQQQILLNAFTEGEAKSTYCNAMIDAHQFVLSLITTGKIVNY
>CP018196.1|AYV92957.1|898158_900399_+|serine-protease
MKHQVKIFFLFSYCLFSLNTLAVSSKEEEISNLKKQIASLQQRLQELEKEKEMENPKKENQKIGLVLSGGGAKGYAHLSLLRFLEKEHIHIDYITGTSIGAFIGSLYSIGYSADEIEKCLNSLNYNDLVKNIAYKRNPHDIITVNYDKKLNFSYPKALASNEFLYLVLKDILKPVEGIQDFDKLPIPLRIIATDLNSGEAKAFSSGDLARVLTASMAIPTLLEPVKIGGISYVDGLISRNFPVQDVIEMGATLVIGSDVGNELKDNLDYNILSVLNQLIAIQSSSSHAEQKKLVHILIEPDIQQYSALDVQKKEEILKLGEEAVEKKKEALLSLAKKEEENIEKNISATPILFFEKLNLSPNFEGKSRIVVEEFLSDIIGKEIGEEELRQKILRVYRLPFISKVYYERRGKELFLDGEVIPENTLGIGFHYQKDYGTAFRLGSTLHHIGKFGNTTNINAKIGDYLGLDLYSLFHYGISDEVGLFSRLAYNERPFYLYEKNHRLASYKKEILKGELGVFTRYQDDLFLSAGMSTNYAKLKLEAGDTDYKYFEYSKNFNNAFLRFRFDNVRNRKSGVKAEAEYKFSTSSTKKNSNIYGPSYQINGYLPISSKLTGLYHLSGGIMQGNRIPVDQYFKIGGLQNNIELNEFSFYGYRPHQKIVDKFMIGNLGIQYEVLNNVYWTGNWNVMAYHSPIDDFEESSKKWRKYIHGFASSFLYESPLGPIELSISRNNQEKEFLTTFSIGYYFE
>CP018196.1|AYV92958.1|900401_901193_-|hypothetical-protein
MSSMLHWVGDMSPESFLLLSILCFLAAFIDSIAGGGGMISLPAFMAVGLPPHIALGTNKVSAAIGTLASSLNFLRSNKIIIPLVTRFAPLALIGAIFGVKTALLIPPNYFQPISFFLLICVFIYSLMNKNLGESYSYSGIHSADIKWGCAFAFVIGFYDGFLGPGTGSFLIFMLIKIFHLDFAHATATTKFINLASNVISAALYFYAGKLNLPLGLIMAVIMIVGAFVGSSLAIYKGSKFIKPVFLLVTITLIGKMGYSFLFI
>CP018196.1|AYV94060.1|901280_902681_+|galactose-mutarotase
MCIRKGSYKAVLCFSKFVIKYPRINQNTLKNIKSILTEEYGYMTCGKMAKEFLLPIYFIPGIPILLQRRCQVYEEGNPKDEEKQKTFIESIQKKNFWRFEVFTDMENIINLGEYQGKIYKHDYDYLDYNFKREWKYFKTKRQQRKRKMKEFVLQNEKLRVTLLSYGAIIQKIEMPDREGNWQNIVLGFEKKEEYLDKNSAYFGAVIGRTAGRTKNGVLKIGEQEYALDKNASGKHSIHGGSHNLSQKYWKGEQEENRVRFSIESPHLENGYPGNAKIEIEYSLEDDSLKLHYRACSDQDTYFNLTNHSYFSLSGNSEEEIGEQYLTLKAEEYGEVDEDTLPIRLASVENTSFDFRVRKQLQELFNSREEQVRIVGQGIDHPFVGNYAKLEDEKSGRCLEVRTNNKAMVIYTANWFREIGRKNHTGIAFEAQELPCLSELKPKEYKVGRVYERETSFRFYIDFQKNK
>CP018196.1|AYV94059.1|902736_904860_+|polyribonucleotide-nucleotidyltransferase
MFDEKTLEMELAGRSLKVSTGKIARQSCGAIMIQYGDTVLLSTVNRSKEARKGVDFFPLTVDYIEKFYAAGKFPGGFNKRESRPSTDATLIARLIDRPIRPMFPEGFTYDVHIVNTVFSFDEKNTPDYLGIIASSLALSISDIPFLGPVAGVVVGYIDGEFVLNPTPEQLEKSLLDLSVAGTKEAVNMVEAGAKELDEETMLKAILFAHENIKKVCAFQEEFVKICGKEKITFEKEEVDPMISSFIEEHGHERLQQAVLTLGKKNREEAVDSLEEELLEAFVAKHYPEIPEEELPEEPILAFKKYYHDLMKTLVREAILYKKHRVDGRSTTEIRPLDAQINVLPIPHGSALFTRGETQSLATATLGTKEDEQLVDNLEKEYYKKFYLHYNFPPYSVGETGRMGAPGRRELGHGSLAERALRYVIPTEEEFPYTIRVVSDITESNGSSSQASICGGSLALMSAGVPIKEHVAGIAMGLIKEGEEFTVLTDIMGLEDHLGDMDFKVAGTKSGITALQMDIKITGITEEIMRIALSQAHVARQQILEVMNAAISSPADLKPNVPRIQQIMIPKDKIAILIGPAGKNIKGIIEETGSTIDITDDGKVSIFSKDADILEHTLRLVNNYVKDVELNEVYEGKVVGIQKFGAFMEILPGKEGLLHISEISKERVSNVEDVLKIGDVFKVKVISMENGKIALSKKKLDVEYKVAE
>CP018196.1|AYV92959.1|904876_906211_+|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MNFAFISLGCSKNLVDSENLTGILVNRKGFQLTNDIEEADMVLINTCGFIGDAKKESIETILEVAEYKQQNLKKIVVCGCLAQRYAEELLQEIPEIDAVIGTGEIDKIERVVDEILQDKKVVETKSFDFLPNADTDRLLTTPPHTAYLKISEGCNRRCTYCIIPQLRGNLRSRSKEDILEEARHLVAGGVRELNLLAQETTEYGIDRYGKKALPDLLRELVKIEELDWIRSYYMFPKSITDELIAVMKTEEKICKYFDIPIQHISSNVLRRMGRAITGEQTKELLYKIRREIPDAVFRTSLIVGFPGETEEEFEELKSFVEEFQFDYIGVFQYSREEDTLAYTMEAQVPEEIKARRQAELINLQNEIAEAKNRKLLGREVEVLIDGISSESEYMLEGRLKTQALDIDGKVLTSEGTAQVGEIVHVVLEQNFEYDFIGRIVQNEK

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Crispr_ID: CP018196_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP018196_4

1372244-1372337

Orphan

Consensus_repeat	Method
AGTTATTCTTTTACAATATTTTAAATTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP018196_4

>merge|CP018196|4|1372244-1372337|CRISPRCasFinder
AGTTATTCTTTTACAATATTTTAAATTCTACGTTTTTTAAATTTGTCGTATTCCCCCTCCAACAAAAGTTATTCTTTTACAATATTTTAAATTC

>CP018196|4|4|1372244-1372337|CRISPRCasFinder
AGTTATTCTTTTACAATATTTTAAATTC	TACGTTTTTTAAATTTGTCGTATTCCCCCTCCAACAAA
AGTTATTCTTTTACAATATTTTAAATTC

Protein	Signature genes	Signature genes Name	Protein_function
CP018196.1\|AYV93318.1\|1363573_1364746_+\|hypothetical-protein	unknown	unknown	unknown
CP018196.1\|AYV93332.1\|1381295_1382303_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
CP018196.1\|AYV93320.1\|1365891_1367430_-\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
CP018196.1\|AYV93326.1\|1375350_1375812_-\|DUF386-family-protein	unknown	unknown	gnl\|CDD\|225345
CP018196.1\|AYV93325.1\|1373798_1375217_-\|pyruvate-kinase-PykF	unknown	unknown	gnl\|CDD\|181699
CP018196.1\|AYV93328.1\|1376646_1377519_-\|N-acetylneuraminate-lyase	unknown	unknown	gnl\|CDD\|179749
CP018196.1\|AYV94081.1\|1369052_1369496_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
CP018196.1\|AYV93317.1\|1363243_1363423_-\|hypothetical-protein	unknown	unknown	unknown
CP018196.1\|AYV93330.1\|1378421_1380275_-\|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl\|CDD\|224509
CP018196.1\|AYV93319.1\|1364759_1365698_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|379118
CP018196.1\|AYV93324.1\|1372457_1373765_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
CP018196.1\|AYV93327.1\|1375958_1376636_-\|N-acetylmannosamine-6-phosphate-2-epimerase	unknown	unknown	gnl\|CDD\|234907
CP018196.1\|AYV94080.1\|1362159_1362759_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
CP018196.1\|AYV93321.1\|1367658_1368189_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP018196.1\|AYV93322.1\|1370093_1371446_-\|cell-envelope-integrity-protein-CreD	unknown	unknown	gnl\|CDD\|377608
CP018196.1\|AYV93323.1\|1371461_1372175_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
CP018196.1\|AYV93316.1\|1361783_1362167_-\|hypothetical-protein	unknown	unknown	unknown
CP018196.1\|AYV93331.1\|1380292_1381282_-\|DctP-family-TRAP-transporter-solute-binding-subunit	unknown	unknown	gnl\|CDD\|270390
CP018196.1\|AYV93333.1\|1382306_1383416_-\|cyclically-permuted-mutarotase-family-protein	unknown	unknown	gnl\|CDD\|274642
CP018196.1\|AYV93329.1\|1377515_1378418_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851

Protein	Function_ID	Function_description	E-value
CP018196.1\|AYV93332.1\|1381295_1382303_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.22428e-29
CP018196.1\|AYV93320.1\|1365891_1367430_-\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
CP018196.1\|AYV93325.1\|1373798_1375217_-\|pyruvate-kinase-PykF	gnl\|CDD\|181699	PRK09206, PRK09206, pyruvate kinase PykF.	0
CP018196.1\|AYV93328.1\|1376646_1377519_-\|N-acetylneuraminate-lyase	gnl\|CDD\|179749	PRK04147, PRK04147, N-acetylneuraminate lyase; Provisional.	3.31159e-177
CP018196.1\|AYV94081.1\|1369052_1369496_-\|N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.97261e-09
CP018196.1\|AYV93330.1\|1378421_1380275_-\|TRAP-transporter-large-permease-subunit	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	6.89984e-148
CP018196.1\|AYV93321.1\|1367658_1368189_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.38288e-14
CP018196.1\|AYV93319.1\|1364759_1365698_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|379118	pfam13310, Virulence_RhuM, Virulence protein RhuM family. There are currently no experimental data for members of this group or their homologs. However, these proteins are implicated in virulence/pathogenicity because RhuM is encoded in the SPI-3 pathogenicity island in Salmonella typhimurium.	1.23384e-30
CP018196.1\|AYV93324.1\|1372457_1373765_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
CP018196.1\|AYV93327.1\|1375958_1376636_-\|N-acetylmannosamine-6-phosphate-2-epimerase	gnl\|CDD\|234907	PRK01130, PRK01130, putative N-acetylmannosamine-6-phosphate 2-epimerase.	7.23168e-124
CP018196.1\|AYV94080.1\|1362159_1362759_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.11459e-37
CP018196.1\|AYV93326.1\|1375350_1375812_-\|DUF386-family-protein	gnl\|CDD\|225345	COG2731, EbgC, Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism].	2.53604e-34
CP018196.1\|AYV93323.1\|1371461_1372175_-\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	5.87052e-05
CP018196.1\|AYV93322.1\|1370093_1371446_-\|cell-envelope-integrity-protein-CreD	gnl\|CDD\|377608	pfam06123, CreD, Inner membrane protein CreD. This family consists of several bacterial CreD or Cet inner membrane proteins. Dominant mutations of the cet gene of Escherichia coli result in tolerance to colicin E2 and increased amounts of an inner membrane protein with an Mr of 42,000. The cet gene is shown to be in the same operon as the phoM gene, which is required in a phoR background for expression of the structural gene for alkaline phosphatase, phoA. Although the Cet protein is not required for phoA expression, it has been suggested that the Cet protein has an enhancing effect on the transcription of phoA.	1.79421e-149
CP018196.1\|AYV93331.1\|1380292_1381282_-\|DctP-family-TRAP-transporter-solute-binding-subunit	gnl\|CDD\|270390	cd13672, PBP2_TRAP_Siap, Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP); the type 2 periplasmic-binding protein fold. This subfamily represents the periplasmic-binding component of TRAP transport system SiaP, a sialic acid binding virulence factor. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.87523e-131
CP018196.1\|AYV93333.1\|1382306_1383416_-\|cyclically-permuted-mutarotase-family-protein	gnl\|CDD\|274642	TIGR03548, mutarot_permut, cyclically-permuted mutarotase family protein. Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.	1.9416e-135
CP018196.1\|AYV93329.1\|1377515_1378418_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	8.12512e-66

>CP018196.1|AYV93323.1|1371461_1372175_-|VWA-domain-containing-protein
MKKVIAGILVVFSLVACANVNLEKGKKNRSMELVFILDRSGSMSGLEKDTIGGYNSMLKKQKEQKGEVFVTTVLFDDKYEMLYHHKPIEELSNMTEKEYFVRGSTALYDAIGKTIVAVNREESVAEKKVDQVLFVITTDGMENASQEFTAKKVKDLIETQKKEKKWEFLFLGANIDAIKTAESFGIEKEKAVNYHADSLGTQKNYKVLGEAVLQMRAEQELKGNWKQEIEEDYKNRK
>CP018196.1|AYV93322.1|1370093_1371446_-|cell-envelope-integrity-protein-CreD
MQNSEMKSNRLLKNPLLTKVFALFIMIVLLQIPLYMVGDLIRERGYLYEETSAKIGNEWGKEQRIAAPFLTVVYPKKSNTEKIQKTVILPDTLEANISLKNEERKRGIYRATVYNANASIQGYFDRNKIPKDPNVEIYLSFGLTDTKAILKVNQYSIGKDQNLKLESGTRAEPFIAKGISSPLSKEDWKEHENIPFHIDIDFRGSGEISVLPFGEMNTVNVSSSWTSPSFTGILPSSREITKEGFYGKWEVTHLVRNYPQVIPVSEEMNYFDFVSEGERKDFESYGVYETKDTNAIRVELFNPVTNYTQVARACKYGILFIMLSIIIVYIFEVASRQFTHYIQYGVVGISLVLFYLLLLSLSEHFPFGISYLLSSLAIIVPNSLYMMSLTRNKKFALGMFVFLTGVYAVLYSILRMEQYALLTGTILILGVLYVIMYLTRRLDIYFKEEE
>CP018196.1|AYV94081.1|1369052_1369496_-|N-acetyltransferase
MEIKEIKENKKQFLSLLLLADEQENMIEQYIDRGIMYILDDSGIKCECVVTDEGNNILEIKNIATVPAYQRQGYAKILIDFIAKTYRKKYSILQVGTGDSPSTIAFYEKCGFIRSHSIPNFFIDNYDHLIYEEGVLLVDMIYLQKKL
>CP018196.1|AYV93321.1|1367658_1368189_-|GNAT-family-N-acetyltransferase
MQIRKAKLEDLDSLVNIHSLTWQAAYKHIFSDTLLKSLRQDNKFLERKEKFKKDIEKNSSIDIFLLETFFNGKMEKVGFLVLSSLKLQKRNNHIAEIIALYILPEFWGQGFGKVMMEFSIERFRRFHAKEIILWVLKDNKRARSFYKKFGFVSTGEEKELPMEHVPEIEYKLIIKN
>CP018196.1|AYV93320.1|1365891_1367430_-|glutamine-hydrolyzing-GMP-synthase
MKECSIVILDFGSQYNQLIARRVREMGVYAEVVPFYEPVDKILARKPKGIILSGGPASVYAEGAPTLDKTLFDHNIPVLGLCYGMQLVTHLFGGEVARAEKQEFGKAELIIDEKEAALFRNIPNNTKVWMSHGDHVTRIADGFHAIAHTDSCIAAVVNPEKNIYAFQFHPEVTHSEHGRDMLQNFVLEVAKCEKNWSMDNYIESTIKVIQEKVGDKKVILGLSGGVDSSVAATLIHKAIGDQLTCIFVDTGLLRKNEAKTVMEVYSEHFHMNIKCVNAEERFLSKLKGVSDPEQKRKIIGKEFIEVFNEEAKKFEDAEFLAQGTIYPDVIESVSVKGPSVTIKSHHNVGGLPEDMKFQLLEPLRELFKDEVREVGRQLGIPHHMIDRHPFPGPGLGVRILGDITKEKADILREADDIFIEELRKAGLYGKVSQAFVVLLPVQSVGVMGDERTYEYVAALRSVNTIDFMTATWSHLPFEFLEKVSNRILNEVKGINRLTYDISSKPPATIEWE
>CP018196.1|AYV93319.1|1364759_1365698_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MHNEIIIYKNGELELPVEVTPDKETVWLNRNQLAVLFDRDVKTIGKHINNALKEELDSSVVAKFATTASDGKTYKVEYYNLDMIISVGYRVKSTRGVEFRRWANKILKDYIVQGYAINERRLAALNRVVEIQSNIIAGVLDLDAEKVLGVVKKYSLALEMLDDYDHQTITKPKISSDEVYKLTYEECRNLISKMSYSETSDIFGKEKGKGLLKGIIDSIYQSAFGEEAYPSIEEKAANLLYFIIKDHPFVDGCKRIAATTFLYFLDMNQILYKNNKKILSDSTLVALTLLIAESKPQEKEIMINIVMNFLTW
>CP018196.1|AYV93318.1|1363573_1364746_+|hypothetical-protein
MFSYNDITSSKLLQSSFYTLSQNKEGIYFEYLPTDFNEMMEQNMIYESEEFSLLLNLFGLDVTSEKLPFSEIRKLLFIEKEKDEINELDLDESDFDLTKDTKKFISSYLKFFNELTEVYPILYILFGDVWTILRYLICKEGLYNGKYKIDFDSASTAYVNLYNDISYILAHREQMKQELLDIFNISSEYKVKLPTSEIALIYQAYNQNRGYDLILNELNPYIKDAENQLMNSWEDIIKILPSKLNEELSFPTCDSLTKFVKQMVQVLIHKEQTLRKCKNCDRYFASRYSSLAEYCTRKVTGTNSTCQEYASKKIYKKKQAENPLYQVFTTYYNRIYGRIRRGSLDKDTTLLDDIKLLHQEFSSKYDTSNDSESKEKIIESFIIEADKLFS
>CP018196.1|AYV93317.1|1363243_1363423_-|hypothetical-protein
MSQITMLSAKDVQKILQVSQAKAYEIIRSLNAELKEKGFYVLQGKINKDYFEERFYGKG
>CP018196.1|AYV94080.1|1362159_1362759_-|site-specific-integrase
MGKKESEEVEFWTVEEFNQFVVAVEDKPHSSLAFRILFWGGLRLGEMLALTVKDFNFDDNTININKSYQRIDQKDIITTSKTPKAVRVVSMPKTVMEEAQNLIACTYGVGKEDRVFTFSKSFLHHEMKRGCKATGVKKIKIHALRHSAISLLIEKGFSVVDIGNRVGHESSEITFRYAHMFPNKQQEMREMLEEVIENV
>CP018196.1|AYV93316.1|1361783_1362167_-|hypothetical-protein
MFRSKSSRETMRQMAKRTEKERLDKLKKKEKNRKRPNTIAFRMSDEERRLFEDRVAMSGLLKQDFIIQSLLFSNVQFLGSTIAIKKIEERLVEIEMMIKSVLKKKELDSVLVEELSTIIELMQNKSL
>CP018196.1|AYV93324.1|1372457_1373765_-|phosphopyruvate-hydratase
MTRIYDVVAREILDSRGNPTVEVDVVLECGAKGRAAVPSGASTGSHEAVELRDGDKARYLGKGVLKAVQNVNTEIKECLVGMNALDQVAVDKAMIALDGTPNKGRLGANAILGVSLAVAKAAAEALGQPLYKYLGGVNAKELPLPMMNILNGGSHADSAVDVQEFMIQPVGAKTFAEAMQMGCEVFHHLGKLLKANGDSTNVGNEGGYAPAKIQGTEGALDLISEAVKAAGYELGKDITFAMDAASSEFAKEADGKYSYHFEREGGIVRSTEEMVAWYQSLVEKYPIVSIEDGLAEDDWAGWQKLTEVLGEKVQLVGDDLFVTNTERLQKGIEFKAGNSILIKLNQIGTLTETLDAIEMAKRAGMTAVISHRSGETEDATIADIAVATNAGQIKTGSTSRTDRMAKYNQLLRIEQELGDMAQYRGMKVFYNIDRK
>CP018196.1|AYV93325.1|1373798_1375217_-|pyruvate-kinase-PykF
MKKTKIVCTIGPKTEAKETLKSLLQSGMNVMRLNFSHGDYAEHGTRIVNFREAMKETGIRAALLLDTKGPEIRTIKLEGGKDVSITAGQTFTFTTDKSVIGNQNKVAVTYEGFPKDLKVGDIVLVDDGLLSMRVTKISGNEVECIAENSGDLGENKGINLPNVKVNLPALAEKDIQDLKFGCEQGVDFIAASFIRKADDVKAVRKVLEENGGAGIQIISKIENQEGLDNFEEILEASDGIMVARGDLGVEIPVEEVPFAQKMMIQRCNAVGKVVITATQMLDSMIKNPRPTRAEANDVANAIIDGTDAVMLSGETAKGKYPLEAVTVMKRIAEKTDPLILPVEDAHLEEEEITVTTAVAKGTADVAEMIGAKVIVVATASGRAARDMRRYFPSADILAITNNEKTANQLVLTRGVTSYVDGTATSLDEFYALAEKAVRELGLATAGDVIIATCGEQVYINGTTNSVKVIHIK
>CP018196.1|AYV93326.1|1375350_1375812_-|DUF386-family-protein
MIYDKIENIGRYLGMSEYLDQAIRYIMTGNYRKAKYGKNIVFGEHIYYNCPEGAMAKNIEGMDYEYHRTYIDIHIPLQGKENIAFFSMETGKEVKAYDQENDYGLYSGKAEGKLCIEEGEFLMLFPEEVHLALMKVEEEVTPIEKVIFKVRAK
>CP018196.1|AYV93327.1|1375958_1376636_-|N-acetylmannosamine-6-phosphate-2-epimerase
MKERMEALRGKLIVSCQALPEEPLHSSYIMSRMAYAAYVGGASGIRANTVSDIREIKKTVDLPIIGIIKEVYGENPVYITPTMKEISALVAEGVDIIAIDATKRERPDGNTLENLMKAAKEKYPNQLFMADISSVEEAIEAERLGFDFVGTTLVGYTEYTKGNLPLVELEKVIQAVSLPVIGEGNLDTPEKAKKALDLGAFAVVVGGAITRPQQITKKFVDEMSK
>CP018196.1|AYV93328.1|1376646_1377519_-|N-acetylneuraminate-lyase
MKGIFSALMVPYNLDGTINEKGLRELVRHNIDVMKVDGLYVGGSTGENFMISTEEKKEVFRIAMEEAKNEVQMMAQVGSINVKESVELGKYATELGYPCLSAVTPFYYKFSFEEIKEYYETIVRETQNNMVIYSIPFLTGVNMDVAQFGELFANPKIIGVKFTAGDFYLLERMRKAYPDKLILSGFDEMLLPAVVMGVDGAIGSTYNVNGIRAKEIFRLGKEGNIAEALELQHVTNDLIEGILGNGLYPTIKEILKCQGVHAGICRKPMAATTEEQTKVAKELYQKYLAK
>CP018196.1|AYV93329.1|1377515_1378418_-|ROK-family-protein
MKQDKIIAIDIGGTNIKYALVSSGGEILSSGNLPTEAEKGIETLLFKLDELIQTYLSEEILGLAVSATGQIDSMQGKVVGGNPIIPGWIGCKLVKILEEKYHLPCVLENDVNCAALGEAWLGAGKGKKDFLCLTIGTGIGGGIILNHQLYRGASSVAGEFGKLYLQNKQEVYEKYASMSALVQKVQEKTGKHWNGKKIFDVYWQGEENIVSIVDEWIHDIVEGLKVLLYLWNPGCIILGGAVTHQGEAFQKKIEEELQKQITPNYLECLELKFANLGNHAGLLGAAFLLLDKMKQEEVKE
>CP018196.1|AYV93330.1|1378421_1380275_-|TRAP-transporter-large-permease-subunit
MKFFNKLEEWIGGTLFVGMFIVLVLQIISRQILDDPLIWSEELARLFFVYVGMLGISMGIRTQSHVMIDFVYARLPKKLQKVIFTGIQIIIFLCITSFSYFGYLLIEKKADIELVSLGISAKWMYIALPVISILMLIRFFQAYQENWEKEKVLISPKIILGFMILFMALLIFQPSVFKIFKMTQYFKLRGNSVYVALVLWLILIFAGVPVGWSLLASSMAYFSMTKWAVAYFASSKFVDSVDSFSLLSVPFFILTGILMNGSGITERIFYFAKASLGHYTGGMGHVNVAASLIFSGMSGSAIADAGGLGQLEIKAMRDEGYDDDICGGITAASCIIGPLVPPSISMIIYGVIANQSIAKLFLAGFVPGVLTTIALMIMNYFVCKKRGYKKAKKCTPKERWEAFKKAFWALLTPIIIIGGIFSGMFTPTEAAVVAALYSVILGMFIYKELTWKGLFQHCVEAMAISGVTVLMIITVTFFGDMIAREQVAMKIAELFIQFASSPLTVLVMINLLLLFLGMFIDALALQFLVLPMLIPVAEQVGIDLVFFGVMTTLNMMIGILTPPMGMALFVVAQVGKMPVSTVTKGVLPFLLPIFITLVVITLFPQIIIFLPNLIMGA
>CP018196.1|AYV93331.1|1380292_1381282_-|DctP-family-TRAP-transporter-solute-binding-subunit
MNLKKLVAMGLVFGAMATAALAAEYELKMGMTAGTSSNEYKAAQFFAKQLKEKSKGEIELKLYPDAQLGKNDLDMMGQLEGGVLDFTFAEMGRFSTFYPEAEVYTLPYMIKNFKHMQNATFNTKFGKDLLKKIETKKNIIVLSQAYNGTRQTSSNKAINSIKDMKGLKLRVPNAPANLAFAKYSGAAPTPMAFSEVYLALQTNSVDAQENPLSAVKAQKFYEVQKYIAMTNHILNDQLYLVSASTMEDLPANLQKVVKEAAIEAAKYHTQLFEKEEASLKDFFKQKGVKITEPKLDEFRAAMKPFYDQYTKKNGKIGQEALKEIQAAAK
>CP018196.1|AYV93332.1|1381295_1382303_-|LacI-family-transcriptional-regulator
MMTQKKIAEMLGISRTTVARALQENSSIKEETRKKVLDLIQETKYEKNYLGSSLAGRKKIVHAFVVKSKNEFYTGEIQRGMQKIQQKYAKYRLEIEVHLHDIHQAQEQVAALENILSQEKQVDGILIVPLEKKKIYHVIKPHLKKIPVISLTMQLHSDIAHIGTDYHRQGRIVANILAHCLRRGESLVILDNGDDKLSTQDYLEGFCERISEEELDILGPYSCQGIQESVELLKKLSQEKKIQGVFSNRYAQDIMKELPDSWFVGKHIVVNGMSEEIEQLLLEKKIIATVTEEVYEEASFAGKLLFQTLYQNKKIPKIWSKTNSKIIYLENLEKK
>CP018196.1|AYV93333.1|1382306_1383416_-|cyclically-permuted-mutarotase-family-protein
MKKLLSILFLTCSCFSFAEHRISWEAVGALPAQKSYDKNIGTAGLLQGMIDDYVIVGGGANFPIKPLTEGGSKVTHKDIYLLKESKNGLDLVEQIQWNTPIGYGASVSTGKEIYYLGGSPEAAHNKDVLKVSVKNGKMKIEKVAELTHGFENGVATYQNGKIYYGVGKIEHEEGKLKNSNRFFVLDLKTGENKELAAFPGEARQQTVGQVLSGKFYVFSGGSSVSYIDGYAYDFEKNVWEKVADVVVNGEKILLLGANSVKISEDEMLVIGGFNHDLWNEASDKLSNLKDKELADYKAQYFGKEPFRYGWNRKILVFNAKENRWRSIGEVPFDAPCGAALLKHGNILYSINGEIKPGVRTPRIFRGEFR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP018196_1	1.2\|547971\|34\|CP018196\|PILER-CR,CRT	547971-548004	34	CP018196.1	20570-20603	0	1.0
CP018196_1	1.21\|547972\|33\|CP018196\|CRISPRCasFinder	547972-548004	33	CP018196.1	20570-20602	0	1.0
CP018196_1	1.17\|548966\|37\|CP018196\|PILER-CR,CRT	548966-549002	37	CP018196.1	1900935-1900971	1	0.973
CP018196_1	1.36\|548967\|36\|CP018196\|CRISPRCasFinder	548967-549002	36	CP018196.1	1900935-1900970	1	0.972

1. spacer 1.2|547971|34|CP018196|PILER-CR,CRT matches to position: 20570-20603, mismatch: 0, identity: 1.0

gcaggaagaattcatcatatgatagtccatcaac	CRISPR spacer
gcaggaagaattcatcatatgatagtccatcaac	Protospacer
**********************************

2. spacer 1.21|547972|33|CP018196|CRISPRCasFinder matches to position: 20570-20602, mismatch: 0, identity: 1.0

caggaagaattcatcatatgatagtccatcaac	CRISPR spacer
caggaagaattcatcatatgatagtccatcaac	Protospacer
*********************************

3. spacer 1.17|548966|37|CP018196|PILER-CR,CRT matches to position: 1900935-1900971, mismatch: 1, identity: 0.973

gaagcaaggagacatacatagacaaagaaaaatattt	CRISPR spacer
gaagcaaggagacgtacatagacaaagaaaaatattt	Protospacer
*************.***********************

4. spacer 1.36|548967|36|CP018196|CRISPRCasFinder matches to position: 1900935-1900970, mismatch: 1, identity: 0.972

aagcaaggagacatacatagacaaagaaaaatattt	CRISPR spacer
aagcaaggagacgtacatagacaaagaaaaatattt	Protospacer
************.***********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP018196_1	1.26\|548304\|34\|CP018196\|CRISPRCasFinder	548304-548337	34	KX077890	Streptococcus phage phiLP081102, complete genome	21757-21790	8	0.765
CP018196_1	1.26\|548304\|34\|CP018196\|CRISPRCasFinder	548304-548337	34	KC413987	Streptococcus phage phiSS12, complete genome	20883-20916	8	0.765
CP018196_1	1.7\|548303\|35\|CP018196\|PILER-CR,CRT	548303-548337	35	KX077890	Streptococcus phage phiLP081102, complete genome	21757-21791	9	0.743
CP018196_1	1.7\|548303\|35\|CP018196\|PILER-CR,CRT	548303-548337	35	KC413987	Streptococcus phage phiSS12, complete genome	20883-20917	9	0.743
CP018196_1	1.7\|548303\|35\|CP018196\|PILER-CR,CRT	548303-548337	35	AP018320	Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome	40287-40321	9	0.743
CP018196_1	1.26\|548304\|34\|CP018196\|CRISPRCasFinder	548304-548337	34	AP018320	Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome	40288-40321	9	0.735
CP018196_3	3.3\|892441\|36\|CP018196\|PILER-CR,CRISPRCasFinder,CRT	892441-892476	36	NZ_CP045275	Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence	90056-90091	9	0.75
CP018196_3	3.8\|892771\|36\|CP018196\|PILER-CR,CRISPRCasFinder,CRT	892771-892806	36	NZ_CP045275	Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence	90056-90091	9	0.75
CP018196_1	1.23\|548104\|35\|CP018196\|CRISPRCasFinder	548104-548138	35	MK448534	Streptococcus satellite phage Javan547, complete genome	2874-2908	10	0.714

1. spacer 1.26|548304|34|CP018196|CRISPRCasFinder matches to KX077890 (Streptococcus phage phiLP081102, complete genome) position: , mismatch: 8, identity: 0.765

atgtaaaaaaagatttttacaagcacgagtatag	CRISPR spacer
atcaaaaacaagatttttacaaccacgagaaagc	Protospacer
**  **** ************* ****** * .

2. spacer 1.26|548304|34|CP018196|CRISPRCasFinder matches to KC413987 (Streptococcus phage phiSS12, complete genome) position: , mismatch: 8, identity: 0.765

atgtaaaaaaagatttttacaagcacgagtatag	CRISPR spacer
atcaaaaacaagatttttacaaccacgagaaagc	Protospacer
**  **** ************* ****** * .

3. spacer 1.7|548303|35|CP018196|PILER-CR,CRT matches to KX077890 (Streptococcus phage phiLP081102, complete genome) position: , mismatch: 9, identity: 0.743

aatgtaaaaaaagatttttacaagcacgagtatag	CRISPR spacer
tatcaaaaacaagatttttacaaccacgagaaagc	Protospacer
 **  **** ************* ****** * .

4. spacer 1.7|548303|35|CP018196|PILER-CR,CRT matches to KC413987 (Streptococcus phage phiSS12, complete genome) position: , mismatch: 9, identity: 0.743

aatgtaaaaaaagatttttacaagcacgagtatag	CRISPR spacer
tatcaaaaacaagatttttacaaccacgagaaagc	Protospacer
 **  **** ************* ****** * .

5. spacer 1.7|548303|35|CP018196|PILER-CR,CRT matches to AP018320 (Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome) position: , mismatch: 9, identity: 0.743

aatgtaaaaaaagatttttacaagcacgagtatag	CRISPR spacer
aagctggtaaaagaattttacaagcacgagaattt	Protospacer
**  *.. ****** *************** **

6. spacer 1.26|548304|34|CP018196|CRISPRCasFinder matches to AP018320 (Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome) position: , mismatch: 9, identity: 0.735

atgtaaaaaaagatttttacaagcacgagtatag	CRISPR spacer
agctggtaaaagaattttacaagcacgagaattt	Protospacer
*  *.. ****** *************** **

7. spacer 3.3|892441|36|CP018196|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045275 (Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence) position: , mismatch: 9, identity: 0.75

atttcttctgataattctttcataacatcaattttt	CRISPR spacer
tcttctcctgataattctttcataaaatacttcatt	Protospacer
 .****.****************** **   *. **

8. spacer 3.8|892771|36|CP018196|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045275 (Bacillus megaterium strain FDU301 plasmid pFDU301C, complete sequence) position: , mismatch: 9, identity: 0.75

atttcttctgataattctttcataacatcaattttt	CRISPR spacer
tcttctcctgataattctttcataaaatacttcatt	Protospacer
 .****.****************** **   *. **

9. spacer 1.23|548104|35|CP018196|CRISPRCasFinder matches to MK448534 (Streptococcus satellite phage Javan547, complete genome) position: , mismatch: 10, identity: 0.714

gattttttgcttgcaatctaaaaaaatattgtata	CRISPR spacer
tcctttttgctttcaatctgaaaaaatacattttt	Protospacer
  .********* ******.********.  * *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

350533 : 355155

Enterobacteria_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYV92482.1\|350533_351238_+	acylneuraminate cytidylyltransferase family protein	A0A1B1IVD3	uncultured_Mediterranean_phage	1.1e-14	30.1
AYV92483.1\|351388_352282_+	glucose-1-phosphate thymidylyltransferase	I7I009	Enterobacteria_phage	3.2e-101	61.5
AYV92484.1\|352260_352836_+	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A291LA62	Escherichia_phage	2.9e-34	40.7
AYV92485.1\|352832_353672_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	7.7e-20	29.7
AYV92486.1\|353668_354769_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	9.9e-68	40.4
AYV92487.1\|354786_355155_-	M15 family peptidase	A9DET4	Yersinia_phage	8.3e-27	47.9

DBSCAN-SWA_2

415950 : 439576

Clostridium_phage(29.41%)

portal,terminase,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYV92541.1\|415950_416556_+	transcriptional regulator	A0A1I9KFA9	Aeromonas_phage	1.3e-08	33.6
AYV92542.1\|416769_417006_+	hypothetical protein	NA	NA	NA	NA
AYV92543.1\|417173_417371_+	DNA-binding protein	NA	NA	NA	NA
AYV92544.1\|417489_417756_+	hypothetical protein	NA	NA	NA	NA
AYV92545.1\|417906_418680_+	hypothetical protein	NA	NA	NA	NA
AYV92546.1\|418681_419137_+	hypothetical protein	NA	NA	NA	NA
AYV92547.1\|419136_420306_+	DUF2800 domain-containing protein	H7BVP9	unidentified_phage	2.0e-87	45.3
AYV92548.1\|420329_420908_+	DUF2815 family protein	S5MC21	Brevibacillus_phage	4.3e-38	47.5
AYV92549.1\|420953_422924_+	hypothetical protein	H7BVQ1	unidentified_phage	1.1e-207	55.1
AYV92550.1\|422933_423176_+	hypothetical protein	A0A2H4JCC5	uncultured_Caudovirales_phage	5.6e-16	56.4
AYV92551.1\|423178_423826_+	HNH endonuclease	A0A2H4JIA5	uncultured_Caudovirales_phage	3.6e-25	32.0
AYV92552.1\|423782_424370_+	hypothetical protein	A0A0E3U2M3	Fusobacterium_phage	4.4e-30	36.3
AYV92553.1\|424366_425020_+	DUF3310 domain-containing protein	Q7Y4J5	Streptococcus_phage	2.5e-10	46.8
AYV92554.1\|425041_427486_+	virulence-associated protein E	A0A0A7RTG3	Clostridium_phage	1.5e-185	42.6
AYV92555.1\|427792_428086_+	VRR-NUC domain-containing protein	A0A2I7QIL0	Bacillus_phage	2.6e-15	50.6
AYV92556.1\|428099_429479_+	DEAD/DEAH box helicase	S5MA26	Brevibacillus_phage	2.4e-143	54.9
AYV92557.1\|429475_429688_+	hypothetical protein	NA	NA	NA	NA
AYV92558.1\|429698_430223_+	hypothetical protein	NA	NA	NA	NA
AYV92559.1\|430380_431205_+	LuxR family transcriptional regulator	NA	NA	NA	NA
AYV92560.1\|431412_431931_+\|terminase	terminase small subunit	A0A0A0RSW5	Bacillus_phage	3.2e-24	37.8
AYV92561.1\|431917_433324_+\|terminase	terminase	A0A090EUA8	Clostridium_phage	3.0e-194	73.7
AYV92562.1\|433336_434731_+\|portal	phage portal protein	A0A0A7S074	Clostridium_phage	1.2e-89	39.4
AYV92563.1\|434717_436307_+\|head	phage head morphogenesis protein	A0A0A8WIE7	Clostridium_phage	3.9e-73	44.2
AYV92564.1\|436299_436581_+	hypothetical protein	NA	NA	NA	NA
AYV92565.1\|436555_437062_+	hypothetical protein	NA	NA	NA	NA
AYV92566.1\|437373_437979_+	hypothetical protein	I1TLE1	Bacillus_phage	3.2e-20	39.0
AYV92567.1\|439186_439576_+	hypothetical protein	A0A0A8WIE8	Clostridium_phage	8.8e-19	40.6

DBSCAN-SWA_3

1060129 : 1067843

Prochlorococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYV93076.1\|1060129_1060750_+	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	4.3e-20	36.0
AYV93077.1\|1060919_1062146_-	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
AYV93078.1\|1062163_1063666_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH	Q58MG4	Prochlorococcus_phage	9.4e-69	46.2
AYV93079.1\|1063667_1064228_-	phosphoribosylglycinamide formyltransferase	R9S626	Prochlorococcus_phage	5.0e-23	35.7
AYV93080.1\|1064215_1065232_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.4e-68	46.2
AYV93081.1\|1065245_1066595_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.5e-45	32.5
AYV93082.1\|1066622_1067339_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3HI61	Synechococcus_phage	5.2e-41	41.9
AYV93083.1\|1067366_1067843_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	5.1e-29	47.4

DBSCAN-SWA_4

1657941 : 1730625

Clostridium_phage(32.0%)

head,integrase,tRNA,tail,capsid,protease,portal,terminase,plate

attL 1677831:1677877|attR 1712108:1712154

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYV93543.1\|1657941_1659216_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	3.6e-93	46.0
AYV93544.1\|1659209_1659824_-	DUF2344 domain-containing protein	NA	NA	NA	NA
AYV93545.1\|1659896_1660898_-	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	NA	NA	NA	NA
AYV93546.1\|1660919_1661399_-	OmpH family outer membrane protein	NA	NA	NA	NA
AYV93547.1\|1661439_1663563_-	outer membrane protein assembly factor	NA	NA	NA	NA
AYV93548.1\|1663633_1667653_-	hypothetical protein	NA	NA	NA	NA
AYV93549.1\|1667668_1668373_-	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
AYV93550.1\|1668374_1670267_-\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
AYV93551.1\|1670284_1670944_-	TrkA family potassium uptake protein	NA	NA	NA	NA
AYV93552.1\|1670957_1672292_-	potassium transporter KtrB	NA	NA	NA	NA
AYV93553.1\|1672306_1673533_-	peptidase T	NA	NA	NA	NA
AYV93554.1\|1673529_1674909_-	MATE family efflux transporter	NA	NA	NA	NA
AYV93555.1\|1674923_1676504_-	ClC family H(+)/Cl(-) exchange transporter	NA	NA	NA	NA
AYV93556.1\|1676496_1677300_-	diaminopimelate epimerase	NA	NA	NA	NA
AYV93557.1\|1677454_1677700_+	hypothetical protein	NA	NA	NA	NA
1677831:1677877	attL	NA	NA	NA	NA
AYV93558.1\|1678027_1679053_-\|integrase	site-specific integrase	A0A0E3Y5J2	Fusobacterium_phage	3.1e-47	35.8
AYV93559.1\|1679185_1679458_-	hypothetical protein	NA	NA	NA	NA
AYV94088.1\|1679690_1680206_-	hypothetical protein	A0A0F6N4L7	Staphylococcus_phage	7.5e-10	31.2
AYV93560.1\|1680228_1680660_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
AYV93561.1\|1680669_1681290_-	XRE family transcriptional regulator	B5WZL2	Staphylococcus_phage	1.1e-18	74.2
AYV93562.1\|1681469_1681670_+	XRE family transcriptional regulator	NA	NA	NA	NA
AYV93563.1\|1681705_1681894_+	hypothetical protein	NA	NA	NA	NA
AYV93564.1\|1682296_1683085_+	phage antirepressor Ant	A0A0A8WIE3	Clostridium_phage	4.7e-35	39.8
AYV93565.1\|1683140_1683377_+	hypothetical protein	NA	NA	NA	NA
AYV93566.1\|1683411_1683669_+	hypothetical protein	NA	NA	NA	NA
AYV93567.1\|1683816_1684029_+	hypothetical protein	NA	NA	NA	NA
AYV93568.1\|1684103_1684289_+	hypothetical protein	NA	NA	NA	NA
AYV93569.1\|1684290_1685382_+	hypothetical protein	A0A139ZPJ9	Marinitoga_camini_virus	2.1e-33	40.6
AYV93570.1\|1686374_1686857_+	hypothetical protein	NA	NA	NA	NA
AYV93571.1\|1686958_1687684_+	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	Q24LD4	Clostridium_phage	4.9e-23	42.2
AYV93572.1\|1687670_1688075_+	hypothetical protein	A0A0E3Y6C4	Fusobacterium_phage	2.0e-13	33.3
AYV93573.1\|1688074_1688293_+	hypothetical protein	NA	NA	NA	NA
AYV93574.1\|1688285_1688558_+	hypothetical protein	NA	NA	NA	NA
AYV93575.1\|1688811_1689036_+	hypothetical protein	NA	NA	NA	NA
AYV93576.1\|1689032_1689332_+	hypothetical protein	NA	NA	NA	NA
AYV93577.1\|1689328_1689757_+	hypothetical protein	NA	NA	NA	NA
AYV93578.1\|1689740_1689968_+	hypothetical protein	NA	NA	NA	NA
AYV93579.1\|1690529_1691216_+	hypothetical protein	NA	NA	NA	NA
AYV93580.1\|1691217_1692027_+	AAA family ATPase	A0A2K9V3L7	Faecalibacterium_phage	3.0e-21	33.3
AYV93581.1\|1692023_1692407_+	hypothetical protein	A0A2I2L3K7	Orpheovirus	1.7e-22	48.4
AYV93582.1\|1692406_1692829_+	DUF1492 domain-containing protein	A0A2K5B275	Erysipelothrix_phage	8.3e-07	31.5
AYV93583.1\|1693108_1693513_+	endonuclease	I2E8Y8	Clostridium_phage	2.7e-07	33.3
AYV93584.1\|1693687_1694179_+\|terminase	phage terminase small subunit P27 family	NA	NA	NA	NA
AYV93585.1\|1694182_1695889_+\|terminase	terminase large subunit	A0A0A7RVS5	Clostridium_phage	1.8e-156	48.9
AYV93586.1\|1695913_1697137_+\|portal	phage portal protein	A6M949	Geobacillus_virus	2.5e-96	46.5
AYV93587.1\|1697129_1697870_+\|protease	Clp protease ClpP	J9QE31	Clostridium_phage	1.6e-37	38.5
AYV93588.1\|1697872_1698988_+\|capsid	phage major capsid protein	A0A288WGE9	Bacillus_phage	4.3e-42	33.1
AYV93589.1\|1698998_1699280_+\|head,tail	phage gp6-like head-tail connector protein	A0A0A7RUM3	Clostridium_phage	7.5e-12	44.4
AYV93590.1\|1699280_1699616_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
AYV93591.1\|1699619_1700051_+	HK97 gp10 family phage protein	NA	NA	NA	NA
AYV93592.1\|1700050_1700485_+	hypothetical protein	NA	NA	NA	NA
AYV93593.1\|1700495_1701563_+\|tail	phage tail sheath protein	A0A0A8WJL8	Clostridium_phage	1.6e-54	35.1
AYV93594.1\|1701575_1702010_+\|terminase	terminase	NA	NA	NA	NA
AYV93595.1\|1702028_1702442_+\|portal	phage portal protein	NA	NA	NA	NA
AYV93596.1\|1703150_1703333_+	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
AYV93597.1\|1703383_1705252_+	hypothetical protein	A0A0E3Y5G6	Fusobacterium_phage	3.2e-26	32.2
AYV93598.1\|1705264_1705705_+\|portal	phage portal protein	NA	NA	NA	NA
AYV93599.1\|1705697_1706678_+\|terminase	terminase	NA	NA	NA	NA
AYV93600.1\|1706670_1707207_+	DUF2577 domain-containing protein	NA	NA	NA	NA
AYV93601.1\|1707185_1707638_+	DUF2634 domain-containing protein	NA	NA	NA	NA
AYV93602.1\|1707634_1708693_+\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	9.0e-66	42.0
AYV93603.1\|1708693_1709263_+	DUF2313 domain-containing protein	A0A2H4J1P4	uncultured_Caudovirales_phage	1.8e-12	35.8
AYV93604.1\|1709255_1709996_+	hypothetical protein	NA	NA	NA	NA
AYV93605.1\|1710011_1710542_+	DUF2977 domain-containing protein	NA	NA	NA	NA
AYV93606.1\|1710615_1710987_+	M15 family peptidase	A9DET4	Yersinia_phage	9.2e-34	54.6
AYV93607.1\|1710991_1711468_+	hypothetical protein	NA	NA	NA	NA
AYV93608.1\|1711477_1711735_+	hypothetical protein	NA	NA	NA	NA
AYV93609.1\|1712340_1713117_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	1.8e-15	30.1
1712108:1712154	attR	NA	NA	NA	NA
AYV93610.1\|1713116_1714151_-	iron ABC transporter permease	NA	NA	NA	NA
AYV93611.1\|1714204_1715668_-	FMN-binding protein	A0A2P0ZL82	Lactobacillus_phage	7.4e-10	35.4
AYV93612.1\|1715839_1716601_-	hypothetical protein	NA	NA	NA	NA
AYV94089.1\|1716597_1717986_-	Na+/H+ antiporter NhaC	NA	NA	NA	NA
AYV93613.1\|1718514_1722096_-	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
AYV93614.1\|1722217_1723420_-	acetate kinase	NA	NA	NA	NA
AYV93615.1\|1723444_1724458_-	phosphate acetyltransferase	NA	NA	NA	NA
AYV93616.1\|1724552_1725596_-	signal recognition particle-docking protein FtsY	D6PHS7	uncultured_phage	1.2e-14	36.4
AYV93617.1\|1725579_1727004_-	pyridine nucleotide-disulfide oxidoreductase	NA	NA	NA	NA
AYV93618.1\|1727018_1727411_-	hypothetical protein	NA	NA	NA	NA
AYV93619.1\|1727407_1728496_-	ribosome biogenesis GTPase YqeH	NA	NA	NA	NA
AYV93620.1\|1728510_1729299_-	recombinase XerD	NA	NA	NA	NA
AYV93621.1\|1729317_1730625_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA

DBSCAN-SWA_5

1746115 : 1755459

uncultured_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYV93638.1\|1746115_1750333_-	filamentous hemagglutinin N-terminal domain-containing protein	A0A0R6PJK4	Moraxella_phage	7.1e-21	29.4
AYV93639.1\|1750441_1751233_-	M48 family peptidase	NA	NA	NA	NA
AYV93640.1\|1751565_1752009_+	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	1.4e-07	30.2
AYV93641.1\|1751995_1752664_+	putative 7-carboxy-7-deazaguanine synthase QueE	S4TZT1	uncultured_phage	1.2e-44	47.9
AYV93642.1\|1752664_1753240_+	GTP cyclohydrolase I FolE	S4U0J3	uncultured_phage	3.6e-45	52.3
AYV93643.1\|1753248_1753944_+	7-cyano-7-deazaguanine synthase QueC	A0A1U9WRB5	Streptococcus_virus	2.9e-65	56.0
AYV93644.1\|1753944_1754427_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	6.3e-51	72.9
AYV93645.1\|1754490_1755459_-	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	2.3e-31	31.8

DBSCAN-SWA_6

1913554 : 1921810

Listeria_phage(12.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYV93808.1\|1913554_1913872_-	ImmA/IrrE family metallo-endopeptidase	A8ATJ8	Listeria_phage	2.0e-05	44.3
AYV93809.1\|1913977_1914415_-	XRE family transcriptional regulator	I3VYZ1	Thermoanaerobacterium_phage	1.6e-05	32.2
AYV93810.1\|1914594_1914798_+	hypothetical protein	NA	NA	NA	NA
AYV93811.1\|1914809_1915046_+	hypothetical protein	NA	NA	NA	NA
AYV93812.1\|1915230_1915743_+	polymer-forming cytoskeletal protein	K4JTL7	Streptococcus_phage	3.3e-05	52.0
AYV93813.1\|1915926_1916703_+	hypothetical protein	F7V9C4	Lactobacillus_virus	3.9e-18	44.5
AYV93814.1\|1916885_1917617_+	hypothetical protein	NA	NA	NA	NA
AYV93815.1\|1917773_1917953_+	hypothetical protein	NA	NA	NA	NA
AYV93816.1\|1917962_1918427_+	hypothetical protein	NA	NA	NA	NA
AYV93817.1\|1918528_1919254_+	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	Q24LD4	Clostridium_phage	4.9e-23	42.2
AYV93818.1\|1919240_1919645_+	hypothetical protein	A0A0E3Y6C4	Fusobacterium_phage	2.0e-13	33.3
AYV93819.1\|1919644_1919863_+	hypothetical protein	NA	NA	NA	NA
AYV93820.1\|1919855_1920128_+	hypothetical protein	NA	NA	NA	NA
AYV93821.1\|1920209_1920623_+	hypothetical protein	B4XYT8	Lactobacillus_phage	6.5e-12	36.7
AYV93822.1\|1920606_1920819_+	hypothetical protein	NA	NA	NA	NA
AYV93823.1\|1920815_1921022_+	hypothetical protein	NA	NA	NA	NA
AYV93824.1\|1921018_1921294_+	hypothetical protein	NA	NA	NA	NA
AYV94091.1\|1921495_1921810_+	hypothetical protein	A0A1L2JY27	Aeribacillus_phage	5.2e-06	29.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP018196

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection