CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
CP032651	Lactobacillus plantarum strain ZFM4 plasmid unnamed3, complete sequence	0 crisprs	NA	0	0
CP032649	Lactobacillus plantarum strain ZFM4 plasmid unnamed1, complete sequence	0 crisprs	NA	0	1
CP032650	Lactobacillus plantarum strain ZFM4 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0
CP032648	Lactobacillus plantarum strain ZFM4 chromosome, complete genome	2 crisprs	cas3,DinG,csa3,csn2,cas2,cas1,cas9,WYL,DEDDh	3	9

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

30031 : 37755

Enterococcus_phage(28.57%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG29405.1\|30031_32200_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	5.2e-254	60.3
AYG29406.1\|32306_33233_+	ribonucleoside-diphosphate reductase	A0A2H4P8A9	Corynebacterium_phage	1.2e-34	31.1
AYG29407.1\|33247_34198_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	9.4e-99	54.6
AYG29408.1\|34325_35138_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	9.4e-15	29.0
AYG29409.1\|35251_35884_+	recombinase family protein	A0A286S1P7	Klebsiella_phage	3.6e-14	33.2
AYG29410.1\|35970_36873_+	YitT family protein	M1Q1P6	Streptococcus_phage	8.2e-52	40.3
AYG29411.1\|36980_37755_+\|transposase	IS5-like element ISLpl3 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.1e-27	53.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP032648

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CRISPR-Cas detection and classification

Crispr_ID: CP032648_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP032648_1

1344789-1345286

TypeII

Consensus_repeat	Method
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	CRT
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	PILER-CR
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	CRISPRCasFinder

7 spacers

csa3,csn2,cas2,cas1,cas9

The CRISPR arrays of CP032648_1

>merge|CP032648|1|1344789-1345286|CRT,PILER-CR,CRISPRCasFinder
CGTGAAACTGTTTTTGATGTGGCCGCTATTCAAGACAAACGTTCTATGCTTCGTTTCCTCAGCATCGTTCTAAACCTGTTTGATATGACTACTATTCAAGACCGTAAATAGGTTGTAAACGTTCAGGTCTGAGTTCTAAACCTGTTTGATATGACTACTATTCAAGACTAATACGATCCATTGACTCCGCTAGTGACAGTTCTAAACCTGTTTGATATGACTACTATTCAAGACTATTCTCGTTTATCGCTTTTAGACGTGTTAGTTCTAAACCTGTTTGATATGACTACTATTCAAGACGTTTGGACTGGTTTATCAAGCAACAAGTTGGTTCTAAACCTGTTTGATATGACTACTATTCAAGACAAGCGCGGGATCACGTGCAACAGCACCATCGTTCTAAACCTGTTTGATATGACTACTATTCAAGACACGTCGGCAAACTGTTCCAATCCTTGACATGTTCTAAACCTGTTTGATATGACTACTATTCAAGAC

>CP032648|1|1|1344789-1345286|CRT
CGTGAAACTGTTTTTGATGTGGCCGCTATTCAAGAC	AAACGTTCTATGCTTCGTTTCCTCAGCATC
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	CGTAAATAGGTTGTAAACGTTCAGGTCTGA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	TAATACGATCCATTGACTCCGCTAGTGACA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	TATTCTCGTTTATCGCTTTTAGACGTGTTA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	GTTTGGACTGGTTTATCAAGCAACAAGTTG
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	AAGCGCGGGATCACGTGCAACAGCACCATC
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	ACGTCGGCAAACTGTTCCAATCCTTGACAT
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC

>CP032648|1|1|1344855-1345286|PILER-CR
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	CGTAAATAGGTTGTAAACGTTCAGGTCTGA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	TAATACGATCCATTGACTCCGCTAGTGACA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	TATTCTCGTTTATCGCTTTTAGACGTGTTA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	GTTTGGACTGGTTTATCAAGCAACAAGTTG
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	AAGCGCGGGATCACGTGCAACAGCACCATC
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	ACGTCGGCAAACTGTTCCAATCCTTGACAT
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC

>CP032648|1|1|1344855-1345286|CRISPRCasFinder
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	CGTAAATAGGTTGTAAACGTTCAGGTCTGA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	TAATACGATCCATTGACTCCGCTAGTGACA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	TATTCTCGTTTATCGCTTTTAGACGTGTTA
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	GTTTGGACTGGTTTATCAAGCAACAAGTTG
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	AAGCGCGGGATCACGTGCAACAGCACCATC
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC	ACGTCGGCAAACTGTTCCAATCCTTGACAT
GTTCTAAACCTGTTTGATATGACTACTATTCAAGAC

Protein	Signature genes	Signature genes Name	Protein_function
CP032648.1\|AYG27650.1\|1345310_1345988_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
CP032648.1\|AYG27654.1\|1351731_1352514_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP032648.1\|AYG27643.1\|1338339_1338795_+\|DUF3021-domain-containing-protein	unknown	unknown	gnl\|CDD\|378668
CP032648.1\|AYG27655.1\|1352538_1353246_-\|hypothetical-protein	unknown	unknown	unknown
CP032648.1\|AYG27658.1\|1357363_1358104_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
CP032648.1\|AYG27657.1\|1354942_1355413_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240033
CP032648.1\|AYG27653.1\|1347366_1351443_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
CP032648.1\|AYG27646.1\|1340037_1340640_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
CP032648.1\|AYG27641.1\|1336137_1336503_-\|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
CP032648.1\|AYG27659.1\|1358185_1359385_-\|putative-hydroxymethylpyrimidine-transporter-CytX	unknown	unknown	gnl\|CDD\|274096
CP032648.1\|AYG27648.1\|1340942_1341701_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350158
CP032648.1\|AYG27647.1\|1340705_1340900_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
CP032648.1\|AYG27651.1\|1345984_1346290_-\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
CP032648.1\|AYG27652.1\|1346267_1347173_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
CP032648.1\|AYG27649.1\|1341985_1344724_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
CP032648.1\|AYG27644.1\|1338882_1339305_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107228
CP032648.1\|AYG27645.1\|1339450_1339924_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
CP032648.1\|AYG27656.1\|1353345_1354710_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|182694
CP032648.1\|AYG27642.1\|1336527_1337760_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340949
CP032648.1\|AYG27640.1\|1333788_1334637_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297

Protein	Function_ID	Function_description	E-value
CP032648.1\|AYG27650.1\|1345310_1345988_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	4.14563e-81
CP032648.1\|AYG27654.1\|1351731_1352514_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.96404e-26
CP032648.1\|AYG27643.1\|1338339_1338795_+\|DUF3021-domain-containing-protein	gnl\|CDD\|378668	pfam11457, DUF3021, Protein of unknown function (DUF3021). This is a bacterial family of uncharacterized proteins.	7.07627e-26
CP032648.1\|AYG27658.1\|1357363_1358104_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	4.48973e-88
CP032648.1\|AYG27657.1\|1354942_1355413_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240033	cd04677, Nudix_Hydrolase_18, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.14377e-57
CP032648.1\|AYG27653.1\|1347366_1351443_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	4.86297e-128
CP032648.1\|AYG27646.1\|1340037_1340640_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	3.18179e-31
CP032648.1\|AYG27641.1\|1336137_1336503_-\|ArsR-family-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	7.3086e-14
CP032648.1\|AYG27659.1\|1358185_1359385_-\|putative-hydroxymethylpyrimidine-transporter-CytX	gnl\|CDD\|274096	TIGR02358, purine-cytosine_transport_protein, putative hydroxymethylpyrimidine transporter CytX. On the basis of a phylogenomic study of thiamine biosythetic, salvage, and transporter genes and a highly conserved RNA element THI, this protein family has been identified as a probable transporter of hydroxymethylpyrimidine (HMP), the phosphorylated (by ThiD) form of which gets joined (by ThiE) to hydroxyethylthiazole phosphate to make thiamine phosphate. [Transport and binding proteins, Nucleosides, purines and pyrimidines, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	1.14314e-146
CP032648.1\|AYG27648.1\|1340942_1341701_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|350158	cd09007, NP-I_spr0068, uncharacterized subfamily of the nucleoside phosphorylase-I family. This subfamily is composed of uncharacterized members including Streptococcus pneumoniae hypothetical protein spr0068. The nucleoside phosphorylase-I (NP-I) family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases such as purine nucleoside phosphorylase (PNP, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases such as AMP nucleosidase (AMN, EC 3.2.2.4) and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Members of the NP-I family display different physiologically relevant quaternary structures: hexameric (trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP); homotrimeric (human PNP and Escherichia coli PNPII or XapA); hexameric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD); or homodimeric such as human and Trypanosoma brucei UP. The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	7.37287e-90
CP032648.1\|AYG27647.1\|1340705_1340900_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	2.12668e-17
CP032648.1\|AYG27651.1\|1345984_1346290_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.01798e-25
CP032648.1\|AYG27652.1\|1346267_1347173_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.7681e-88
CP032648.1\|AYG27649.1\|1341985_1344724_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
CP032648.1\|AYG27644.1\|1338882_1339305_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107228	cd06471, ACD_LpsHSP_like, Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.	2.47416e-43
CP032648.1\|AYG27645.1\|1339450_1339924_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	0.000122978
CP032648.1\|AYG27656.1\|1353345_1354710_-\|amino-acid-permease	gnl\|CDD\|182694	PRK10746, PRK10746, putative transport protein YifK; Provisional.	0
CP032648.1\|AYG27642.1\|1336527_1337760_-\|MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.1962e-140
CP032648.1\|AYG27640.1\|1333788_1334637_-\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	1.59711e-120

>CP032648.1|AYG27649.1|1341985_1344724_+|cation-transporting-P-type-ATPase
MIKDDNQSLTSNEEQNDTQNPPDADNLWQLDESALAAKYATDPENGLSTAEAAERLQHNGRNELETKRTSRFVQFIKQFNNSIIYILAAAAVLTFFMHHYSDSIVIGLVIIANAIIGYVQERQAGNALERIREMLISKNFVIRDGKKLEIDARELVVGDLVNLEAGDAVPADMRLISADNFNVQESVLTGETNPVEKQEEPITETTPALADRKNMVYASTAVTSGSAVGIVTATAEDTEIGHIQQSVSDVKQTTTPLMRNLNSLGVDLSIAIVVAAVLLFLLGMVMDTYSLPTLLIAVITMVVGSMPEGLPASTSVVLAMGTRQMTKKNVIVKSLPAVETLGAVDIVNTDKTGTLTKNEMTVTKVVTPEHTFDVTGVGYDDNGGVNFDGHLKLNGNKVDWHQDNAMEWLVKIAGQTTDAELHFENNRWELTGEPTDGALTTLYRKMTGHDPEVEEVDSLPFDSAFRFSARLADLDGQRLLMVKGSPATVLRLTDQANQTAYWDDAMDDLTADGLRVVALAYQEVDDDVTTIDAQAIGGLHLAGLVGIIDPPREEAATAIAELRQAGVQVKMITGDHPDTAMAIANKLNLAANVKAITGPEIDAMDDQQLQAHIDDYNVFARATPNNKLRIVRAQQANNHVVSMTGDGVNDAPALKQADIGVAMGIKGTEVAKESADMVLADDDFADIVAAVREGRHVFDNIRKTIRFLLPTSFAEGLVVIISILMGHELPLYPTQLLWINMVSALTIQFAFIFEPPEAGIMARGPRNVKSGLLSKLDYFEIGYVSFLISGLGIFAYDYLTALGLPNVVGSTMSLNIIIFGKIFYLFNLRNDHPVISKYFFQNKMAFYIIGILILLQLGIIYLPFMQSVFHTTSINFWYGWGIPIICGIVVLIVTEVGKSIRFRWMGKDGVID
>CP032648.1|AYG27648.1|1340942_1341701_-|purine-nucleoside-phosphorylase
MTDKLTLLQYDPNPTAMVGPDVDGRFTVPAKLLYIFSGDDYFQQFVTRYHGHRLGQFNTITKVSWVYQIGYRGQKLAVAQAPLGSPAATMYLEMLIDFGARTVIAVGSCGALTALPEEQLLIPTVALRDEGTSFHYLAAADWVPLDPKVIQVLGTTLTKACLPWQMVKTWTTDAFFRETVSKVKAARQQGCQVVEMECSALAACSAFRQVSFGQLLYTADTLAQLEHYDPRHWGAGGVLVAIELATESLAAY
>CP032648.1|AYG27647.1|1340705_1340900_+|PspC-domain-containing-protein
MKIDIHRSATDRVIAGVIGGIAEHFNWNTNVTRLLFVVLAITPMFPGIIAYLILWLLMKDPIKD
>CP032648.1|AYG27646.1|1340037_1340640_+|NADPH-dependent-oxidoreductase
MFKIAIILGSTRSQANGRALFNHLKLIIDQLPTHSTIHYQFLDLANYQLPLFDEPEPPMANPHRELPANQQQWLTDMASADGYIILTPEYNHAMPAGLKNAFDFLAFEGARKPAKIISYSDNMRGGQFGAAALVPVLQRLGMVVLPKPTPIGNVPQTLQSNGHFIDNAPLSKRYDHALHQALTEITYYTTVLTTTPFPTD
>CP032648.1|AYG27645.1|1339450_1339924_-|MarR-family-transcriptional-regulator
MTTPLVSQLMTELNQFLTQDSVDDQEKRWAMQQTTDPQLQAALKQLSTTDIKIIAYLGRRGASRAKSLPAPTELSQATISRGLTKLSRLKLATKYRDLTNNKEILVRLTTLGEAVADLHTQLDAAIAAKAQAIADDYSDAELRRFVSLMRRIREIKI
>CP032648.1|AYG27644.1|1338882_1339305_-|Hsp20/alpha-crystallin-family-protein
MANTLMNRNDFGMLDPFERMARSFWAPLENMDQVLKTDINETDDQYQVKVDVPGIDKQDVKLDYRDNVLSIKVQKDSFVDHEDQDQNIVMNERHTGTLQRQYMLPNVAADKITASQADGVLTITLPKTQPSANDGQIEIQ
>CP032648.1|AYG27643.1|1338339_1338795_+|DUF3021-domain-containing-protein
MKRLWHTLLIGAIGGIVIGYLMALGFSTFFNTTYLFPSNPTFVSHWSSPLAATQLSTLLWILIGEVWAFSSWLFEIETWSITKQTIAHCLCSYLGMTPLAILCGWFPLNVRWFGFYTLVYTGAYIGLWLIEMALARIKVIQLNQQLTNHRS
>CP032648.1|AYG27642.1|1336527_1337760_-|MFS-transporter
MDDAERERGPWHRNLIVLWFCTFVAGMAFSEIMPFLSLFVSQLGDFTKAQITFYSGLAFAADYAISAISAPLWGIIADKKGRKIMLLRASLGMAVAMGLMGFVTNVWQLVALRALQGVFAGFISNAQALVASQTPRKYSGRALSTLITGAVSGQLFGPVIGGLLAQLFSIRNTFFITAGLLMVAFLLSLFFVQEHFKPVAHHREPGDSRNPLAAFQNPRLIIVMLCSTAIVQFGNASIAPIISLYVRELMHYRGPITVVAGIIAALPGISNIFSAPRLGRYGDQHGSGKVLLFGYIFAVIMYFPQGIVTSVVALGILRFAIGISDGALYPEIQTVLTKNTPVHLTSTIFSYNQSFQAIGNMFGALLGGLVAGWFNYNAVFIMTALLLLINLGLILWLVPDIWKNGKRAVS
>CP032648.1|AYG27641.1|1336137_1336503_-|ArsR-family-transcriptional-regulator
MASCLFCYLSLNMMLIQCIVSFMNIEISKQDQADQQRVAIFKALADANRLRIIRVLYQAQREMTCSEVGAQLNISKSTVSYHFKTLRLVGLTNTRRKAQTKYLSLQLATFDRFLPGFLATL
>CP032648.1|AYG27640.1|1333788_1334637_-|aldo/keto-reductase
MTVLTTMYQLANGVNIPKVVFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVGQAIRDSGIPREQIFVTTKLPAETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVGRVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNILNQATIPPMVNQIQYYLGFTEPKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPKAVNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG
>CP032648.1|AYG27650.1|1345310_1345988_-|type-II-A-CRISPR-associated-protein-Csn2
MNITYYPFPPFKIDAGKVNVLDLGNSNMYAEVCQGFRDRIDSVRISNDDLELQTISSQCNWYGDLMLSVDLNRLFLKKVQTQIIKLMADDRQVAVLDENRKVVSQVMEASFLLDLPLDVDESPSLEQILKFTGIHFPTALMNDPRAILEALVQTHVELGLKQKLVLTNVSHYLNQKQWASFEQLVHDLGATVIVIEYSEINRMEKFKNSCYYYVDEDLVDWRDMN
>CP032648.1|AYG27651.1|1345984_1346290_-|CRISPR-associated-endonuclease-Cas2
MRLIVMFDVPMDTSEERRAYRHFHKALVREGFLMMQYSTYVRVCVNKKAAEFVEKRIAPLAPKGGKVQTMTVTEKQYQAMHYIQGTPSNDILNSAERTIVI
>CP032648.1|AYG27652.1|1346267_1347173_-|type-II-CRISPR-associated-endonuclease-Cas1
MGWRNVIITQHAKVSYSMNRILVQTSSDKYAVPISDIQLLLVGTTQAVITSAALCALTEAHVKVIFTDHQGEPISETNDYYPTRRTADLVRQQVTWPEARIATLWTKNVGSKILNQIQVIDFVGGDTQTLVDELDKLELNDVTNREAVVANKYFSLLFGDQFYRRDFSPINAALNYGYAVLLSMVNREIVLNGYLTCIGIHHENNENEFNLGSDLMEPFRPIVDQWVSQQRFKDFTPDIKIGLVSLLDLEIGFNGHQTIVSHAITEYVAACLHYLSGETEELKIEVKLPNEVSSDAINSHV
>CP032648.1|AYG27653.1|1347366_1351443_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKEPYGVGLDIGTNSVGWTVVDASGHVRKIKGQTGIGVRLFKEGAAAADRRGFRTTRRRLKRVKWRLRLLREFFDQPISKVDINFFARRKYSDVSPRDPNYNGLEKTLFNDRSDQDFYHDYPTIYHLREALMTQHRKFDVREIYLAIHHIVKYRGNFLRNDAATAYRSGTLDLQQHFETLNHLFSQADLELNLNLTTDVALLDSIKQTLVRTDISRSDRQKLIMPLLAVLTGATTAEKKRQKAVVTEFAKALVGNKTKIDVLTLTDIDATEAKDWAFSLEENQDKLPGIEDRFSEVGQQIIDEVIRLYASVNLAQLIPEGKRFSQSMVEKYKRHGEDLKLLKAYIRSQSDAKRGRAIRATYDQYIDGVKSKQVTQEAFQKALGKFVDADVDLNSWAAQIKQAIDSEQFMPKLRTKQNGAIPYQVQQNELDQIISNQKEYYPWLGEENPVIKRRGKFPYKLDELVGFRVPYYVGPLITKEMQAATANAGFAWMVRKADGPITPWNFDDKVDRVASATAFIQRMQTTDTYLIGEEVLPARSLIYQRFMVLNELNNIRVDDGQLTPRQKQRLYNQVFKKHKRVTAKNIQDNLVAAREFPTAPRITGLADPKVFNSSLSTYHDLKQVLPEAMSDVRKQADIEKIILWSTIFEDSTIFKQKLTEISWLTAAQLKQLGQLRYRGWGQLSRKLLTGLKDDNNRSIMDGLWETNANFMQLRSQPAIENQIKSANQANLTTADLQDTINELYTSPQNKKAIREVMVVLADIKDAMHGQTPNWIFVEAARGGGVAGRRTQSRSKQIVAAYQGTAQAIVRDQVQRELKEKIKNKANFNTRLVLYFLQNGRDLYTGDAINIDRLSEYDIDHILPQSLVKDDSLDNRVLTNARINREKNDTFASEKFGKKMGAKWKEMHRMGLMTKRKLDHLLMRPDEISKYATGFINRQLVETRQVIKLVEELINAEYPSTAIVSVKANLTHQFRQTFDFPKIREVNDYHHAFDAALTAFIGTYLLKRYPKLERFFVYGKFAKQPVNLTRFNVIRKLAKTDTPITDIDTGEVLWDKLTDIKYFETLYDYKRLLVTREVSENYGAMFDQTLLKASDNGKRLIRKKQSFDTAIYGGYTGKTLAYMAIVKVSTKKDVQYQVVGVPTTMVTQIEQLEQQGMTNKQAVTKVIEPLIAANNKKMLTYEVLLPKVRFEQVVRDRIKGQTHRFALGTDTYYHNIQELYLPLTLQRAFLGKQNESEVQLNQNLLTVFDATLAQVNRYFPLYEMNKFKKILNSARDQIELLEAKNQFVKNKLVLGKQGILTNMFIGLHANASYGDLKVLGVKIDFGKLQVPGGIKLTGDAEIIYQSPTGLFERKIALKDL
>CP032648.1|AYG27654.1|1351731_1352514_-|alpha/beta-hydrolase
MRFITSDHVQLDYTDEGQGQPIVILTGFGGAKDIWRAQIPVLIQAGYRVINLDGRCQGLSEHTAKGLRMSRRAVDAHELIEKLQLEQPILLGNSMGAATWFAYVSLYGDTGIKALIDVDQTPRMINTPHWQYGFKQVQWQDIPDYFRMPLGHSTFKHIDDATYARVKAVEAQAPFDAKLMFPLLVNHAVQDWRDVIRQLTVPFLIIAGAKSPFFNPDFAAVTAQMALRGQSVVIPEAGHIVMAEQSAAFNKALLEFLATC
>CP032648.1|AYG27655.1|1352538_1353246_-|hypothetical-protein
MVKQGHYAKVSKQKRLRQLKQRRQAQEKRAIMPEMVSEFLQVRYHLTQAAKQRPVMRQMMQRFMAQWLAAGQAELSDNGQTTWSVVALTKQTLQTFNRQLPWQGYALVDQEMARWTAFLNKEVPAVPLSERITLTEALSPATWQACLSEQLAINALLALTGDSRQLGQITTEQVRQLQTSIQTATGIDWEKVAQLLDSTVIAQNTLSEAGLDDKTRQWLEKLKKLTPQDFNDHVE
>CP032648.1|AYG27656.1|1353345_1354710_-|amino-acid-permease
MQRKLSTGQMQMIALGGTIGVGLFMGSSSTIKWTGPSVLIAYIVSGAFLYLIMRALGEMLYVDPNTGSFAKFASEYIHPVFGYLTAWSNIFQFVVVGMSEMIALGGYCRYWWPNLPDWIPGLIAIVFLCAANLISVKMFGTLETWFSLIKVVTIILMIIAGLGLIIFGIGNGGHPIGISNLWTHGGFFTGGVKGFVFALAIVLASYQGIELIGVTAGEAENPQSTIVKAIRSTVARILIFYVGAIFVIVSIYPWDKLSQIGSPFVQTFAKIGITAAASIINFVVITASLSGTNSGIYSASRMTYTLAESHQLPRKMTLLNRHGVPFYSVIAIATGILIGVVLNVVLPMFFKDASEIFVMVYSSSVLPGMVPWFVILVSQIAFRKQNAAKMANHPFKMPLSPYSNYLTLAFLALTLVFMFINPETRYSILVGVVFLVIMTLIYFRKYAGNKEETL
>CP032648.1|AYG27657.1|1354942_1355413_+|NUDIX-domain-containing-protein
MANYIKEIRALVGHKPIILNTAAGILVNDQQQILLNLRTDTHNWSLPGGYLEYGETYATACVREYKEDSGIDVEVVDRIGIFDKGETAYPNGDVAQTISALFLVKPIGGHVLTQATDETLKLDYFDFDNLPPLLNQQNADMIHAAQEYLQTHSATK
>CP032648.1|AYG27658.1|1357363_1358104_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MVKPIIGIAPGVVTVNSQMFPGRVRDYVNRDYLKSVTDNGGVPLVLPVTTDATTIERYVGMIDGLLLCGGADVAPLTYGEEPQPKLGGVDPERDQYEIALIRATHAVGKPVLGICRGLQILNVCYGGNLYQDMSELPAGQGTLKHMQGQLAAYGMHHVKVVPGTTLAEYLGTTSDAITVNSFHHQAVKQVATGFQVVAQSADQVVEAIEATAGGLQLGVQWHPEMMQQVNSVQARLFAAFMRACVA
>CP032648.1|AYG27659.1|1358185_1359385_-|putative-hydroxymethylpyrimidine-transporter-CytX
MKHDGIFRSQFLLWLGAAISIAEILTGTLMAPLGLTRGLAAIVLGHMIGCGLFLVPAGYLGAKLHQSALASAQLAFGRGGVLLASGLNALQLVGWTAVMIVNAQLAMNSISGKLFGFRSPLLMATIVAILIIAWLLMGSQLLFKINNAVVGLLVLGTVLMLVMVFMAPTTSQSVSTTSMTFGQAVELNVTMALSWLPLIGDYTQRVDRPLPVALVSAGGYMLGSLVMFVTGLLVVLRTGQTDITALLTRSGLGLVALLIIVFSTVTTTFLDTYSAATSLANLTGSRHVNRLAVGVTVVGLLIALTVAMTYYQNFLYLIGSVFTPLYAIIFVTYFVRHATLPYWLNFCWWVVGIVAYYQLQAIDFIGGTTLLVLVGLSIAVWLTGIIVKPTELEYRELSH

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Crispr_ID: CP032648_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP032648_2

1962139-1962279

Orphan

Consensus_repeat	Method
GAGCAACCAAGTCAACCGGAAGAACCGGGTCAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of CP032648_2

>merge|CP032648|2|1962139-1962279|CRISPRCasFinder
AAATCGGCAATCCAACCGGAAGAACCGGGTCAACCTGAGCAACCAAGTCAACCGGAAGAACCGGGTCAACCTGAGCAACCAAGTCAACCAGAAGAGCCGGGGCAACACGAGCAACCGAGTCAACCGGAAGAACCGGGTCAA

>CP032648|2|2|1962139-1962279|CRISPRCasFinder
AAATCGGCAATCCAACCGGAAGAACCGGGTCAA	CCTGAGCAACCAAGTCAACCG
GAAGAACCGGGTCAACCTGAGCAACCAAGTCAA	CCAGAAGAGCCGGGGCAACAC
GAGCAACCGAGTCAACCGGAAGAACCGGGTCAA

Protein	Signature genes	Signature genes Name	Protein_function
CP032648.1\|AYG29354.1\|1955857_1957126_+\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225827
CP032648.1\|AYG28164.1\|1953682_1954108_+\|cell-surface-protein	unknown	unknown	unknown
CP032648.1\|AYG28175.1\|1970346_1971831_+\|glutamate/gamma-aminobutyrate-family-transporter-YjeM	unknown	unknown	gnl\|CDD\|237929
CP032648.1\|AYG28160.1\|1949716_1950112_+\|iron-sulfur-cluster-biosynthesis-family-protein	unknown	unknown	gnl\|CDD\|366687
CP032648.1\|AYG28173.1\|1968186_1969359_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341467
CP032648.1\|AYG28167.1\|1957471_1957606_-\|4-hydroxybenzoyl-CoA-thioesterase	unknown	unknown	unknown
CP032648.1\|AYG28172.1\|1965995_1967117_+\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176239
CP032648.1\|AYG28162.1\|1951829_1952534_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
CP032648.1\|AYG28170.1\|1963435_1963705_+\|cupredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379208
CP032648.1\|AYG28169.1\|1963045_1963420_+\|cupredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|226980
CP032648.1\|AYG28171.1\|1963704_1965630_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
CP032648.1\|AYG28168.1\|1957744_1958506_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP032648.1\|AYG28178.1\|1973614_1974505_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187613
CP032648.1\|AYG28166.1\|1957129_1957414_+\|TfoX-domain-protein	unknown	unknown	gnl\|CDD\|377439
CP032648.1\|AYG28177.1\|1972935_1973361_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176863
CP032648.1\|AYG28163.1\|1952590_1953655_+\|DUF916-and-DUF3324-domain-containing-protein	unknown	unknown	gnl\|CDD\|368712
CP032648.1\|AYG28165.1\|1954100_1955588_+\|cell-surface-protein	unknown	unknown	gnl\|CDD\|375438
CP032648.1\|AYG28161.1\|1950136_1951105_+\|NADPH:quinone-reductase	unknown	unknown	gnl\|CDD\|176215
CP032648.1\|AYG28174.1\|1969654_1970050_-\|transglycosylase	unknown	unknown	unknown
CP032648.1\|AYG28176.1\|1971957_1972779_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045

Protein	Function_ID	Function_description	E-value
CP032648.1\|AYG29354.1\|1955857_1957126_+\|GHKL-domain-containing-protein	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	5.50653e-09
CP032648.1\|AYG28178.1\|1973614_1974505_+\|SDR-family-oxidoreductase	gnl\|CDD\|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.18063e-138
CP032648.1\|AYG28175.1\|1970346_1971831_+\|glutamate/gamma-aminobutyrate-family-transporter-YjeM	gnl\|CDD\|237929	PRK15238, PRK15238, inner membrane transporter YjeM; Provisional.	0
CP032648.1\|AYG28160.1\|1949716_1950112_+\|iron-sulfur-cluster-biosynthesis-family-protein	gnl\|CDD\|366687	pfam01521, Fe-S_biosyn, Iron-sulphur cluster biosynthesis. This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.	3.55441e-20
CP032648.1\|AYG28173.1\|1968186_1969359_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341467	cd08188, PDDH, 1,3-Propanediol (1,3-PD) dehydrogenase. This family includes 1,3-propanediol (1,3-PD) dehydrogenase, a key enzyme in the microbial production of 1,3-PD that has been previously characterized as the product of dhaT gene in Klebsiella pneumoniae. 1,3-PD dehydrogenase is a member of the family III metal-dependent polyol dehydrogenases, which are shown to require a divalent metal ion for catalysis. However, some members of this family showed a dependence on Fe(2+) or Zn(2+) for activity.	0
CP032648.1\|AYG28172.1\|1965995_1967117_+\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176239	cd08278, benzyl_alcohol_DH, Benzyl alcohol dehydrogenase. Benzyl alcohol dehydrogenase is similar to liver alcohol dehydrogenase, but has some amino acid substitutions near the active site, which may determine the enzyme's specificity of oxidizing aromatic substrates. Also known as aryl-alcohol dehydrogenases, they catalyze the conversion of an aromatic alcohol + NAD+ to an aromatic aldehyde + NADH + H+. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
CP032648.1\|AYG28162.1\|1951829_1952534_+\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	1.74207e-32
CP032648.1\|AYG28170.1\|1963435_1963705_+\|cupredoxin-domain-containing-protein	gnl\|CDD\|379208	pfam13473, Cupredoxin_1, Cupredoxin-like domain. The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.	3.9659e-20
CP032648.1\|AYG28171.1\|1963704_1965630_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
CP032648.1\|AYG28169.1\|1963045_1963420_+\|cupredoxin-domain-containing-protein	gnl\|CDD\|226980	COG4633, COG4633, Plastocyanin domain containing protein [General function prediction only].	1.52584e-33
CP032648.1\|AYG28168.1\|1957744_1958506_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	5.00029e-17
CP032648.1\|AYG28166.1\|1957129_1957414_+\|TfoX-domain-protein	gnl\|CDD\|377439	pfam04994, TfoX_C, TfoX C-terminal domain. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with pfam00383 in Neisseria meningitidis TadA. It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.	1.71819e-21
CP032648.1\|AYG28177.1\|1972935_1973361_+\|SRPBCC-family-protein	gnl\|CDD\|176863	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins. The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.	0.000351798
CP032648.1\|AYG28163.1\|1952590_1953655_+\|DUF916-and-DUF3324-domain-containing-protein	gnl\|CDD\|368712	pfam06030, DUF916, Bacterial protein of unknown function (DUF916). This family consists of several hypothetical bacterial proteins of unknown function.	1.17785e-47
CP032648.1\|AYG28165.1\|1954100_1955588_+\|cell-surface-protein	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	0.00941488
CP032648.1\|AYG28161.1\|1950136_1951105_+\|NADPH:quinone-reductase	gnl\|CDD\|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	3.40416e-66
CP032648.1\|AYG28176.1\|1971957_1972779_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.65267e-09

>CP032648.1|AYG28168.1|1957744_1958506_+|AraC-family-transcriptional-regulator
MGTELQFVQYLHQMRDYNDQHPTTKGLILLGYLERDFIRFYRAGKIEEGIQFAKKNLTRSRDLLNKLSSEEKQLQLSALVDVLAFEGIQNHAEIYEFVKLRNDYHRWLVKLPVTTERYQPLVVQIIRDFAAIAKPNALAYNAHLESTLDVMYYTNAHLHDQLSVKKVLAHVNARCNPESVRRSFSQEMHMSIRDYINAKKIQEAEHMLLATDLTIRAIAAELCFYDAADFSKRFKKETGQTPLEFRQLNTRTD
>CP032648.1|AYG28167.1|1957471_1957606_-|4-hydroxybenzoyl-CoA-thioesterase
MILTNIFYLTINTQKRLSLVIWDNRFKAIIFMLTNSHKVKKVWS
>CP032648.1|AYG28166.1|1957129_1957414_+|TfoX-domain-protein
MIMNRKDLNLVALLTTLPNIGPTLAKQLQAVAITTPEQLKSTGSKVAFTAIKKANPHACIQLLYSLQGAIENCAYPQLSPATREDLKQFFRSLL
>CP032648.1|AYG29354.1|1955857_1957126_+|GHKL-domain-containing-protein
MIGFREYVTWRIAIIWLSLVIITMSLGEVASNLWPQVPLAYFWIIPIVCVTTFMSSRLLYTQWILMLPVAIFLNALKRLVGAIMGVIAKAVAQSASPMLLRQAIGLHSTADINLFLASIMMLPVIIILGMLAHRWLVQVSAADFLQRARVNISDYLLVILFFAIYIIAYVFAMEWSVNAQTYMAIAAIVTFGIIGSYLISNKNSHLNDAQLLLQVSNYNELLSHHNRDLHLFKHDYENILLSMSAFIQNNDMAGLKRYFTTEVMPARVTLNRQSGLSDLSRLDMPTVSGLIYAKYEAANGQNVHLVVTILEKVTLADIPQIKVVRILGNLLDNATDAAARANHQVALTVKNRDAHTTVFSITNQIPTHEAVDLSVIKKSRFTTKPGHLGYGLSSIEQLTTDQLVVNYCIEEGNFIAELIIKH
>CP032648.1|AYG28165.1|1954100_1955588_+|cell-surface-protein
MRNRRVKWLLILVFGILGLLNLLPLEGNAATLTSKMTDVKANAAFQAVPGGNSVGSNVDNGLQAYPALGNVSANYADNGRITRQTTQITMTMTGSITLKSSNSMSKAYFDIMAGPASGSYTGATLVTATPTSLGSGNSIMISSSKQTQTLSVNFQNIKSELPIYIGFRITVNGEEGTYQLGRFNAQTLSPKITGTLYSTDTTIKGTGTPGNTISSNVNGVTTTVGSDGTYTLNLGTALGTLSNVTVTEVDEITGDKGTATAAVTLKKLNITSSKTAVDLYPGDLDSLTSDSAVVAWLVKQAGIVATNPDSATDTITYAADETSLASKLSSLAVGSSTTINIYGKGSSGLKSDAKAITVTMRDGTLSLGTLPASLTFGTLTIPFKETLYQPTNAWNITVNDTRKTGSQWYLRATATAMKSSTRTMSGNLIYLNAGNKQVLTNTSVTVSSGKKIAGTTSTNAASGWSSSQGILLDVQPSVQIDSYSGTINWTLQDTP
>CP032648.1|AYG28164.1|1953682_1954108_+|cell-surface-protein
MPNKWWRLILGVMLVLSWAIPVRAATHGRTEISVGFYETKYSADRIIPARVIPDGGHPYVIRPADPGTQGQRNQSERKPIRRQLIIDGWLRGQSRNGQQLPQTSERLVIGSILGGMGLLASVLAGALYRILKRQDGGERNA
>CP032648.1|AYG28163.1|1952590_1953655_+|DUF916-and-DUF3324-domain-containing-protein
MQLLKRIMVIVGTLILGLQVSSVSGLAASNASSSSSKTTQSNDIGFSVAAKIPNNQIDQHNSYFDLKMTRGRQQQIQTTIYNVTNADIKVQTAIHTAYTNGNGIIEYVTPTKSYDPSLKYRMDQITKIQGPTTITIPANGSKVVTATVTMPKQAVNGVILGGWYFKRVANKVTGSVKGSMNIANQYSYVIGLKYTAGIVPQPQLKLDTITAGMQNYRRGVFPQLRNVTAVIVPKLTITARLTSKNSGKVIKNFTQKNVQLAPNSVYKVPILTGTNRLQAGSYHVRLVAKNTDHRWVFDKDFVISTAAADKYNQASVDDSGMSVGWFILFGALGMLIIGLIGLLIFFWIKKRRRA
>CP032648.1|AYG28162.1|1951829_1952534_+|WxL-domain-containing-protein
MKPMLGHLLMAGTLLLAGSTPIVANAAENRSGNTDIKAEFTKSTSTVTPVDPSNPDVPSTDGDGDNGAAAGGDLSLIFVSKSLGYGTHELDVLNDQQYKVDPTSSYTLLWQDKMVVEVSDVRGTNAGWKLTVTGSNLTGTDGTAAKGATLSLPKGDVVNSGSEANGAVATASEVALNGTVGSSAVLNADKGGGSGVTVSRLDPKALTLNIKANTVKAQAYSANLNWTLSDLPTN
>CP032648.1|AYG28161.1|1950136_1951105_+|NADPH:quinone-reductase
MKSVIFDDFGSPDVLRIADVQRPVATTATVLVKVMAVAVNHVDTFVRSGAFKTALAAPHVAGRDLVGEVVASSQPDFQIGDQVWTNSMGYEGRMGATAEYVAVPTDRLYHVPDGVAPMPLVAAVHSAATAAIVLNDVMEIRRGQTLLIEGAAGNVGRKLIQLAHQMGVTAVITASPRDFARCQQLGSTACYDYHAGFADQLTTDQWTFDHVIDTSGRVPLAINLALLRLGGQVTLITAPQDNQFEFPVRQFYMSQQRITGFVISHATVDQLAQAASRLNRAFSAGLLLDDQVSQRYFKDAAQCHAQLEAGTDHHQRFVLLPS
>CP032648.1|AYG28160.1|1949716_1950112_+|iron-sulfur-cluster-biosynthesis-family-protein
MTQIEISDRLKALLVAKGFDKKQLVLVTDDGGGKYSLHGGACSIGTKFTIIVLDQPDPEYNVTVVNDQGLALWTSTYDLIFFNDGIKMDYDQGRIAIKDNAHMLDNAVQIAKGAEVLAAFEQGVPADNLTC
>CP032648.1|AYG28169.1|1963045_1963420_+|cupredoxin-domain-containing-protein
MMIKVLVLLIGGLAIGFILWWFFGKHATTTVTASAVDDLQQVDVEVKGGYSPEQIVLKKGVPAVLNFTRKDASGCLDHVVFSDFGINQELPQNQVEAITIDTSKSGEYQWACGMDMFHGKLIIK
>CP032648.1|AYG28170.1|1963435_1963705_+|cupredoxin-domain-containing-protein
MSARQQINITVDGHYDPAEVTLQQGVPAQLTFTRTSTQGCLEQVHSTDLHFTTELPLDQPQTVTVPTDRAGEFHFSCGMDMVSGKVVIA
>CP032648.1|AYG28171.1|1963704_1965630_+|copper-translocating-P-type-ATPase
MSTTKRFWISLIFSLPLLANMILMPFGWMLPGGDWTQLILTTIIMAVSARPFLQSSWASFTKHHANMDTLVAIGTATAYFYSLYAMATGQAVFFESAALVTTFVLLGQVFEERMRHNASSAVAKLVGLQAKEAEVLRNQEFVKVPLDQVVVGDIIRVKPGEKIPVDGVITTGRSTVDESMVTGESMPVQKTVADAVIGSTINSNGTFQFKASKVGDQTMLAQIVELVKKAQNSHAPIQKLTDKVSDIFVPIVLIIAIVTFLTWYVFLNASLANALIFAVAVVVIACPCALGLATPTALMVGTGRGAKMGILIKNGEVLEAVNDVKTVIFDKTGTITVGHPQVTDVIGDEAQVLRVATSLEAASEHPLAAAILKRGTARGIQAPTATNFQAIEGKGVTAQVEGQLAVVGNHKLLTDEPISAELQRQATELQDAAKTVVYVGLNHEIIGLIAIQDVAKSTSEVAIASLKARGLKTVMLTGDNERVAQAVADQVGIDEVIADVLPGDKADHVHAFQKAGKVAFVGDGINDAPALTTADVGIAMGSGTDIAIDAGGIVLVKNDLRDVDRALALSKKTFNRIKLNLFWAFVYNVLGIPVAAGLFFAIGLTLSPELAGLAMAFSSLSVVTSSVLLNKAKISSNAQPA
>CP032648.1|AYG28172.1|1965995_1967117_+|NAD(P)-dependent-alcohol-dehydrogenase
MKIKAAVVDKVNDPFVIKDDIELAEMKATDLQIKMVATGICHSDEAIRRGDASLGYPVILGHEGSGIVEKVGSEVTNFEVGDHVILSFYADGTCDNCLKGMPTKCRNYADYNLSGTRPDGSDHFQENGHHISDMFDQSSFTTHTVVDQRNAVKVPKELDLRRLGPLGCGYVTGSGTVLNSLQPRPGQTIAVFGTGAVGLAAMMAGKISGCTEVIAVDIVDSRLELAKELGATHAINSKKEDPVEAIKKLTHGYGVDFAVDTTGVEPVMVSAIHALAQGGTAALIAVTAKNITISSWNDLCVDDKKVIGVNMGDAIPGVDIPRLIDFYQHGMFPFEKTEKFYKFEDINQANADSGSGKTIKPVLIIDEDYQPGK
>CP032648.1|AYG28173.1|1968186_1969359_-|iron-containing-alcohol-dehydrogenase
MTERNFDFLMPSVNFFGPGVISKIGERAKTLGMHKPVIVTDKFLESLPDGAVAQVRRSLDAAGIDYVIYNQVEPNPKIHNIQAVKALYQANQADSLITIGGGSAHDTGKGAGIIMTNGDDITKLAGIETLKNALPPLIAVNTTAGTGSELTRHCVITNEETHYKFVVASWRNMPLVSFNDPTLMLDVPKGLTAATGMDAFVQAIEPFVSVDHNPITDSQCIQAIKLIETSLREAVANGHNLEARTHMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNLIACPERFAELAKIMGENTDGLSTRDAAELAIKAMKQLSEDVGIPHSIKEIGAKIEDFEHMATNALKDGNAFSNPRKGTKEDIIKIFQAAYDAK
>CP032648.1|AYG28174.1|1969654_1970050_-|transglycosylase
MKKFNFKTMLLLVLASCVFGVVVNVTTSLGPQTTITAQASKKLSQAQQIAKINAKLSKANRAAKNWIAYRESGYSYTARNGRCYGRYQLLRSYLHGNLSPVNQEKRANTYVASRYGSWVKAKRFWQHHHWY
>CP032648.1|AYG28175.1|1970346_1971831_+|glutamate/gamma-aminobutyrate-family-transporter-YjeM
MATKDNEKITLMALVMMIFTTVFGFANSTVAYYLMGYSSILFYLVAAVLFFIPFALMMAEFGAAVKSDSSGMYKWLEVSVNAKFAFVGTFMWFASYIIWLVSTSAKVWIPFTTIFFGSDQTQRFAMFGLNATQMIGILSCLWMVLVTFVSIKGMKGIVRVTSLGGLAVTSLTAILLVVSGVVLALNHGQFAQPLQHVMTSPNPSYQHPVGLLGFAVFAIFAYGGLEVLGGMVDKTKNPEKTFPRGIIISAIVITLGYGLGIFCWGISTNWQAVLSNPTTNLGNISYVMMQNLGYVLGQALGLSTAAAKTMGLWFARYTGLGMFLAYSGAFFTLTYSPLKTLILGTPKELWPKKFTKLNKAGMPSYAMMVQCAIVIVIILVASFATADASAFYNVLTLMANVSMTLPYLFLLYAFPKFKENQNIVKPFEVYKSLAWTKIISWVVFIVVLGANVFTLIQPILETGQIQNTIWMLVGPIVFGVAGIIWYQVRERHVN
>CP032648.1|AYG28176.1|1971957_1972779_+|XRE-family-transcriptional-regulator
MTLGTALKQARKAKQLNQKQAARGICAQSMLSAIENDRYVPNARLLLALCQRLGVAVSTLSLADDFEISAEQAFNDRVRQMCNAHQYQQLKDWLLQPTTLEHVQTDEQTQAYYYYLGVACWQVDRTSDAAQQNLRLAIGMAAPSSPPTTLTRLALISLAVVKAHHHPQVPVAALVTRALADIDASAYEENANIVFYLAGLVAYEQHDSQLAVARLTQGLAFATTHDSHYMLANIYQLMAQLAMAAGETATAQVASQRSQVFKDLFKEQINDRL
>CP032648.1|AYG28177.1|1972935_1973361_+|SRPBCC-family-protein
MTTALFTNQVLTQATPATVRALLADPLNLPAWATAITTVKPTATGYVLQRSGSAFDQPEQLQVTVGADQVVYHSEGGQLGYEIVFTMTPLAERTAVQEEVSLTTTPPSWLPLPLVKPVMQRDFQRKLGQLATLAEEQPNDD
>CP032648.1|AYG28178.1|1973614_1974505_+|SDR-family-oxidoreductase
MNQPELRDPRYLYKTDGFDKQDQETPALQAKMRPEPDCGEKSYQGHDKLLNRRVLITGGDSGIGRATAIAFAREGADVAIQYLPGEEPDAEAVAELVRAAGRQALLLPCDFKDVDVVTDLVDRTIAEFGGIDTLVLNAGQQISQPSLAKLPIEQVRATFEVNIVAMFALAQAALPKMPAGGSIVTTTSIQAYAPSGHLLDYAATKAAIKNFTINLAAEAAEKGIRVNGVAPGPIWTPLQLDQGQPIEALPKFGQDTLLKRAGQPAELAPVYVFLASNDASYVTAQIYGVTGGGVIN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP032648_1	1.2\|1344891\|30\|CP032648\|CRT,PILER-CR,CRISPRCasFinder	1344891-1344920	30	JX486087	Lactobacillus phage ATCC 8014-B1, complete genome	790-819	1	0.967
CP032648_1	1.2\|1344891\|30\|CP032648\|CRT,PILER-CR,CRISPRCasFinder	1344891-1344920	30	JN051154	Pediococcus phage clP1, complete genome	6473-6502	1	0.967
CP032648_1	1.6\|1345155\|30\|CP032648\|CRT,PILER-CR,CRISPRCasFinder	1345155-1345184	30	NZ_CP015089	Pelagibaca abyssi strain JLT2014 plasmid pPABY5, complete sequence	37190-37219	7	0.767
CP032648_1	1.5\|1345089\|30\|CP032648\|CRT,PILER-CR,CRISPRCasFinder	1345089-1345118	30	NZ_CP040048	Acinetobacter baumannii strain VB1190 plasmid unnamed1, complete sequence	611914-611943	8	0.733
CP032648_1	1.5\|1345089\|30\|CP032648\|CRT,PILER-CR,CRISPRCasFinder	1345089-1345118	30	MK721187	Enterococcus phage vB_EfaS_Ef6.1, complete genome	161-190	8	0.733

1. spacer 1.2|1344891|30|CP032648|CRT,PILER-CR,CRISPRCasFinder matches to JX486087 (Lactobacillus phage ATCC 8014-B1, complete genome) position: , mismatch: 1, identity: 0.967

cgtaaataggttgtaaacgttcaggtctga	CRISPR spacer
cgtgaataggttgtaaacgttcaggtctga	Protospacer
***.**************************

2. spacer 1.2|1344891|30|CP032648|CRT,PILER-CR,CRISPRCasFinder matches to JN051154 (Pediococcus phage clP1, complete genome) position: , mismatch: 1, identity: 0.967

cgtaaataggttgtaaacgttcaggtctga	CRISPR spacer
cgtgaataggttgtaaacgttcaggtctga	Protospacer
***.**************************

3. spacer 1.6|1345155|30|CP032648|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP015089 (Pelagibaca abyssi strain JLT2014 plasmid pPABY5, complete sequence) position: , mismatch: 7, identity: 0.767

aagcgcgggatcacgtgcaacagcaccatc	CRISPR spacer
aagcgcgggatcacctggaacagctcggag	Protospacer
************** ** ****** * .

4. spacer 1.5|1345089|30|CP032648|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP040048 (Acinetobacter baumannii strain VB1190 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gtttggactggtttatcaagcaacaagttg	CRISPR spacer
tggtggacaggtttatcaagcaacaaagat	Protospacer
   ***** *****************.

5. spacer 1.5|1345089|30|CP032648|CRT,PILER-CR,CRISPRCasFinder matches to MK721187 (Enterococcus phage vB_EfaS_Ef6.1, complete genome) position: , mismatch: 8, identity: 0.733

gtttggactggtttatcaagcaacaagttg	CRISPR spacer
atcaaaactggtttctcaaacaacaagttt	Protospacer
.*. ..******** ****.*********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

169100 : 178938

Lactobacillus_phage(87.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG26630.1\|169100_170096_-	glycosyltransferase	S5FKN0	Shigella_phage	3.1e-52	38.8
AYG26631.1\|170722_170860_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
AYG26632.1\|170955_171396_+	nucleoside 2-deoxyribosyltransferase	A0A2P0ZL88	Lactobacillus_phage	8.0e-77	99.3
AYG26633.1\|171466_172027_-	hypothetical protein	A0A2P0ZL75	Lactobacillus_phage	2.7e-101	100.0
AYG26634.1\|172114_174553_-	flavocytochrome c	A0A2P0ZL82	Lactobacillus_phage	0.0e+00	99.5
AYG26635.1\|174555_175170_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	6.3e-112	100.0
AYG26636.1\|175513_176461_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	2.7e-178	100.0
AYG26637.1\|176646_177618_+	peptidase S41	A0A2P0ZL68	Lactobacillus_phage	2.9e-180	98.5
AYG26638.1\|177708_178938_-	hypothetical protein	A0A2P0ZL72	Lactobacillus_phage	2.7e-215	97.7

DBSCAN-SWA_2

579943 : 644373

Lactobacillus_phage(23.08%)

integrase,transposase,protease,bacteriocin,tRNA

attL 618004:618025|attR 620838:620859

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG26982.1\|579943_580273_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
AYG26983.1\|580408_581737_-	glucarate dehydratase	NA	NA	NA	NA
AYG26984.1\|581885_582779_+	LysR family transcriptional regulator	NA	NA	NA	NA
AYG26985.1\|582927_583905_+	4-phosphoerythronate dehydrogenase	A0A285PXZ1	Cedratvirus	2.1e-32	32.3
AYG26986.1\|583919_585317_+	hypothetical protein	NA	NA	NA	NA
AYG26987.1\|585619_586395_-\|transposase	IS5-like element ISLpl3 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.1e-27	53.2
AYG26988.1\|586728_588063_-	gluconate permease	NA	NA	NA	NA
AYG26989.1\|588312_589527_+	mandelate racemase/muconate lactonizing enzyme family protein	Q6A202	Oenococcus_phage	2.5e-48	33.8
AYG26990.1\|589542_590685_+	lactonase family protein	NA	NA	NA	NA
AYG26991.1\|590777_591446_-	histidine phosphatase family protein	NA	NA	NA	NA
AYG29319.1\|591577_592147_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
AYG26992.1\|592197_592962_-	YibE/F family protein	NA	NA	NA	NA
AYG26993.1\|592958_594209_-	YibE/F family protein	NA	NA	NA	NA
AYG26994.1\|594172_595174_-	hypothetical protein	NA	NA	NA	NA
AYG26995.1\|595593_596358_-	NADPH-dependent oxidoreductase	NA	NA	NA	NA
AYG26996.1\|596710_597037_+	ArsR family transcriptional regulator	NA	NA	NA	NA
AYG26997.1\|597228_598110_-	RluA family pseudouridine synthase	NA	NA	NA	NA
AYG26998.1\|598152_599961_-	DNA helicase RecQ	M1PGQ0	Moumouvirus	1.0e-77	36.1
AYG26999.1\|600218_600434_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AYG27000.1\|600635_600902_+	hypothetical protein	NA	NA	NA	NA
AYG27001.1\|600952_602185_+	hypothetical protein	NA	NA	NA	NA
AYG27002.1\|602220_603627_+	C69 family dipeptidase	NA	NA	NA	NA
AYG27003.1\|604078_605086_+	aspartate--ammonia ligase	A0A1C9C5F0	Heterosigma_akashiwo_virus	1.4e-63	43.0
AYG27004.1\|605124_606420_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	7.1e-57	31.2
AYG27005.1\|606480_607098_+	FMN-dependent NADH-azoreductase	NA	NA	NA	NA
AYG27006.1\|607206_607680_+	MarR family transcriptional regulator	NA	NA	NA	NA
AYG27007.1\|607955_609845_-	FAD-binding protein	A0A2P0ZL82	Lactobacillus_phage	5.2e-16	26.2
AYG27008.1\|610031_610958_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	3.2e-19	25.8
AYG27009.1\|611028_611580_-	helix-turn-helix domain-containing protein	X2CXD8	Lactobacillus_phage	8.4e-07	48.4
AYG27010.1\|611679_612432_-	XRE family transcriptional regulator	NA	NA	NA	NA
AYG27011.1\|613081_613204_-	hypothetical protein	NA	NA	NA	NA
AYG27012.1\|617093_617624_+	histidine phosphatase family protein	NA	NA	NA	NA
AYG27013.1\|617937_618171_-	hypothetical protein	NA	NA	NA	NA
618004:618025	attL	NA	NA	NA	NA
AYG27014.1\|618137_618542_-	restriction endonuclease subunit S	NA	NA	NA	NA
AYG27015.1\|618546_619128_+	restriction endonuclease subunit S	NA	NA	NA	NA
AYG27016.1\|619138_620056_-\|integrase	site-specific integrase	A8ATM2	Listeria_phage	2.7e-74	44.7
AYG27017.1\|626095_628630_-	M1 family peptidase	A0A0P0IY26	Acinetobacter_phage	3.5e-68	27.4
620838:620859	attR	NA	NA	NA	NA
AYG27018.1\|628811_629384_-	alpha-L-rhamnosidase	NA	NA	NA	NA
AYG27019.1\|629489_629822_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
AYG27020.1\|630183_631194_-	DUF4767 domain-containing protein	NA	NA	NA	NA
AYG27021.1\|631325_632156_-	FAA hydrolase family protein	NA	NA	NA	NA
AYG27022.1\|632329_632770_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
AYG27023.1\|632830_633253_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
AYG27024.1\|633267_633450_-	hypothetical protein	NA	NA	NA	NA
AYG27025.1\|633462_634008_-	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
AYG27026.1\|634019_634274_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
AYG27027.1\|634514_636362_-	acetyltransferase	A0A1R3Y5Q6	Salmonella_virus	5.8e-20	23.7
AYG27028.1\|636351_636735_-	hypothetical protein	NA	NA	NA	NA
AYG27029.1\|637219_639727_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
AYG27030.1\|640000_641299_+	MFS transporter	NA	NA	NA	NA
AYG27031.1\|641375_642251_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.8e-20	28.9
AYG27032.1\|642259_642967_-\|transposase	transposase	NA	NA	NA	NA
AYG27033.1\|643122_643467_-	transcriptional regulator	NA	NA	NA	NA
AYG27034.1\|643686_644373_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

843746 : 852370

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG27199.1\|843746_844742_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	7.7e-51	37.9
AYG27200.1\|844880_845666_-	acyl-ACP thioesterase	NA	NA	NA	NA
AYG27201.1\|845669_846566_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.9e-80	55.3
AYG27202.1\|846664_847012_-	initiation-control protein YabA	M1PFV3	Streptococcus_phage	2.4e-12	33.3
AYG27203.1\|847036_848056_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.1e-32	33.5
AYG27204.1\|848072_848402_-	hypothetical protein	NA	NA	NA	NA
AYG27205.1\|848398_849064_-	thymidylate kinase	M1PSC7	Streptococcus_phage	1.4e-53	52.7
AYG27206.1\|849461_849713_-	DUF2508 family protein	NA	NA	NA	NA
AYG27207.1\|849727_850327_-	recombination protein RecR	NA	NA	NA	NA
AYG27208.1\|850342_850651_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
AYG27209.1\|850672_852370_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	3.9e-55	37.0

DBSCAN-SWA_4

871890 : 943465

Lactobacillus_phage(89.36%)

integrase,portal,protease,lysis,terminase,capsid,tRNA,tail

attL 938960:938975|attR 947059:947074

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG27232.1\|871890_873303_-\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	3.1e-45	30.0
AYG27233.1\|873580_875071_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
AYG27234.1\|875396_876572_-	PIN/TRAM domain-containing protein	NA	NA	NA	NA
AYG27235.1\|876587_877967_-	DNA repair protein RadA	NA	NA	NA	NA
AYG27236.1\|878108_878315_+	hypothetical protein	NA	NA	NA	NA
AYG27237.1\|879093_879630_-	dUTP diphosphatase	J9PV85	Bacillus_phage	2.4e-35	45.8
AYG27238.1\|879768_880065_+	N-acetyltransferase	NA	NA	NA	NA
AYG27239.1\|880073_880757_+	ribose-5-phosphate isomerase RpiA	NA	NA	NA	NA
AYG27240.1\|880832_882164_+	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	5.4e-68	33.3
AYG29327.1\|884124_884817_-	peptidase M10	NA	NA	NA	NA
AYG27241.1\|885235_885913_-	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	NA	NA	NA	NA
AYG27242.1\|886062_887088_-	EamA family transporter	NA	NA	NA	NA
AYG27243.1\|887520_888483_-	AEC family transporter	NA	NA	NA	NA
AYG27244.1\|888792_889986_+	LytR family transcriptional regulator	NA	NA	NA	NA
AYG27245.1\|890053_890827_-	hypothetical protein	NA	NA	NA	NA
AYG27246.1\|890819_891623_-	acetyl-CoA carboxyl transferase	NA	NA	NA	NA
AYG27247.1\|891619_892942_-	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
AYG27248.1\|892944_893346_-	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit	NA	NA	NA	NA
AYG27249.1\|893356_894328_-	3-oxoacyl-ACP synthase III	NA	NA	NA	NA
AYG27250.1\|894491_895010_-	PTS fructose transporter subunit IIB	NA	NA	NA	NA
AYG27251.1\|895006_895426_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
AYG27252.1\|895496_898346_-	sigma-54-dependent transcriptional regulator	NA	NA	NA	NA
AYG27253.1\|898652_899039_-	DUF956 family protein	NA	NA	NA	NA
AYG27254.1\|899167_900100_-	PTS mannose/fructose/sorbose transporter family subunit IID	NA	NA	NA	NA
AYG27255.1\|900118_900928_-	PTS mannose/fructose/sorbose transporter subunit IIC	NA	NA	NA	NA
AYG27256.1\|900963_901938_-	PTS mannose transporter subunit IIAB	NA	NA	NA	NA
AYG27257.1\|902228_903083_-	hypothetical protein	NA	NA	NA	NA
AYG27258.1\|903510_904443_-	lysin	A0A2P0ZLG2	Lactobacillus_phage	6.9e-171	92.3
AYG27259.1\|904442_904727_-\|lysis	lysis protein	A0A2P0ZLE8	Lactobacillus_phage	4.1e-42	97.9
AYG27260.1\|904726_904936_-	hypothetical protein	A0A2P0ZLG4	Lactobacillus_phage	9.8e-09	58.0
AYG27261.1\|904941_905322_-	hypothetical protein	A0A2P0ZLF7	Lactobacillus_phage	3.2e-50	76.0
AYG27262.1\|905338_905773_-	hypothetical protein	A0A2P0ZLE9	Lactobacillus_phage	9.7e-59	79.9
AYG27263.1\|905774_906266_-	DUF1617 family protein	A0A2P0ZLE0	Lactobacillus_phage	2.8e-46	62.5
AYG27264.1\|906289_911155_-	hypothetical protein	A0A2P0ZLE1	Lactobacillus_phage	0.0e+00	52.0
AYG27265.1\|911174_911996_-\|tail	phage tail protein	A0A2P0ZLE2	Lactobacillus_phage	1.3e-149	95.6
AYG27266.1\|911999_916592_-\|tail	phage tail tape measure protein	A0A2P0ZLF1	Lactobacillus_phage	0.0e+00	78.6
AYG27267.1\|916610_916853_-\|tail	phage tail tape measure protein	A0A2P0ZLD9	Lactobacillus_phage	3.3e-32	98.6
AYG27268.1\|916855_917170_-	hypothetical protein	A0A2P0ZLF3	Lactobacillus_phage	2.4e-51	96.2
AYG27269.1\|917263_917875_-\|tail	phage tail protein	A0A2P0ZLF5	Lactobacillus_phage	9.6e-105	96.1
AYG27270.1\|917889_918312_-	hypothetical protein	A0A2P0ZLE4	Lactobacillus_phage	2.8e-71	97.9
AYG27271.1\|918308_918716_-	hypothetical protein	A0A2P0ZLD7	Lactobacillus_phage	1.0e-65	93.3
AYG27272.1\|918712_919102_-	hypothetical protein	A0A2P0ZLD1	Lactobacillus_phage	1.5e-63	90.7
AYG27273.1\|919082_919388_-	hypothetical protein	A0A2P0ZLD5	Lactobacillus_phage	1.2e-47	95.0
AYG27274.1\|919526_920699_-\|capsid	phage major capsid protein	A0A2P0ZLD6	Lactobacillus_phage	6.6e-110	54.5
AYG27275.1\|920721_921444_-\|protease	Clp protease ClpP	A0A2P0ZLE3	Lactobacillus_phage	9.7e-96	75.4
AYG27276.1\|921430_922573_-\|portal	phage portal protein	A0A2P0ZLC9	Lactobacillus_phage	4.0e-213	97.6
AYG27277.1\|922591_924271_-\|terminase	terminase large subunit	A0A2P0ZLE5	Lactobacillus_phage	0.0e+00	98.0
AYG29328.1\|924267_924555_-	hypothetical protein	A0A2P0ZLC8	Lactobacillus_phage	1.1e-42	95.8
AYG27278.1\|924664_924907_-	hypothetical protein	A0A2P0ZLD2	Lactobacillus_phage	5.6e-40	100.0
AYG27279.1\|924924_925167_-	hypothetical protein	A0A2P0ZLD3	Lactobacillus_phage	8.6e-33	83.8
AYG27280.1\|925166_925505_-	HNH endonuclease	A0A2P0ZLC6	Lactobacillus_phage	2.8e-61	96.4
AYG27281.1\|925488_925725_-	hypothetical protein	A0A2P0ZLC2	Lactobacillus_phage	1.8e-19	72.9
AYG27282.1\|926108_927380_-	hypothetical protein	NA	NA	NA	NA
AYG27283.1\|927395_928265_-	DNA adenine methylase	A0A1S5PRR3	Streptococcus_phage	8.9e-80	51.4
AYG27284.1\|928600_929032_-	hypothetical protein	A0A2P0ZLC0	Lactobacillus_phage	2.5e-67	93.4
AYG27285.1\|929043_929352_-	hypothetical protein	A0A2P0ZLD0	Lactobacillus_phage	1.7e-46	90.1
AYG29329.1\|929483_929969_-	adenine methyltransferase	A0A2P0ZL79	Lactobacillus_phage	2.1e-78	93.8
AYG27286.1\|930036_930528_-	methyltransferase domain-containing protein	O03918	Lactobacillus_phage	5.8e-84	89.9
AYG27287.1\|930926_931124_-	hypothetical protein	A0A2P0ZLB7	Lactobacillus_phage	7.3e-30	95.4
AYG27288.1\|931104_931446_-	VRR-NUC domain-containing protein	A0A2P0ZLB6	Lactobacillus_phage	1.5e-59	95.6
AYG27289.1\|931700_932966_-	helicase	A0A2P0ZLC4	Lactobacillus_phage	5.8e-229	94.1
AYG27290.1\|932962_933757_-	DNA primase	A0A2P0ZLB0	Lactobacillus_phage	2.1e-136	92.0
AYG27291.1\|933827_934460_-	hypothetical protein	A0A2P0ZLB9	Lactobacillus_phage	4.6e-102	97.3
AYG27292.1\|934462_935179_-	NTP-binding protein	A0A2P0ZLB2	Lactobacillus_phage	1.5e-112	97.7
AYG27293.1\|935175_936435_-	DEAD/DEAH box helicase	A0A2P0ZLA5	Lactobacillus_phage	8.0e-231	96.7
AYG27294.1\|936586_937066_-	RNA helicase	A0A2P0ZLB3	Lactobacillus_phage	1.8e-77	89.9
AYG27295.1\|937336_937567_-	XRE family transcriptional regulator	NA	NA	NA	NA
AYG27296.1\|937873_938155_-	hypothetical protein	NA	NA	NA	NA
AYG27297.1\|938292_938565_-	hypothetical protein	A0A2P0ZLA9	Lactobacillus_phage	1.2e-43	100.0
AYG27298.1\|938564_938768_-	hypothetical protein	A0A2P0ZLA4	Lactobacillus_phage	1.5e-30	98.5
AYG27299.1\|938839_939328_+	DUF2321 domain-containing protein	Q6SEF3	Lactobacillus_prophage	2.7e-33	43.5
938960:938975	attL	NA	NA	NA	NA
AYG27300.1\|939455_939665_-	XRE family transcriptional regulator	NA	NA	NA	NA
AYG27301.1\|939916_940324_+	XRE family transcriptional regulator	Q9T1J3	Lactobacillus_phage	1.2e-10	36.0
AYG27302.1\|940333_940807_+	hypothetical protein	NA	NA	NA	NA
AYG27303.1\|940897_941578_+	hypothetical protein	NA	NA	NA	NA
AYG27304.1\|941774_942137_+	hypothetical protein	E9LUS2	Lactobacillus_phage	1.4e-58	94.2
AYG27305.1\|942307_943465_+\|integrase	site-specific integrase	A0A2P0ZL94	Lactobacillus_phage	3.6e-217	98.2
947059:947074	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1028924 : 1089534

uncultured_Mediterranean_phage(20.0%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG27371.1\|1028924_1030196_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	4.5e-96	43.7
AYG27372.1\|1030662_1032276_-	CTP synthetase	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.2e-143	49.9
AYG27373.1\|1032448_1033057_-	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
AYG27374.1\|1033101_1033542_-	DUF1934 domain-containing protein	NA	NA	NA	NA
AYG27375.1\|1033904_1034837_+	lipoate--protein ligase family protein	NA	NA	NA	NA
AYG27376.1\|1034851_1036204_+	HD domain-containing protein	A0A1B1ISR1	uncultured_Mediterranean_phage	5.2e-26	32.9
AYG27377.1\|1036223_1037033_+	sugar-phosphatase	NA	NA	NA	NA
AYG27378.1\|1037202_1038189_-	hypothetical protein	NA	NA	NA	NA
AYG27379.1\|1038271_1039294_-	YdcF family protein	NA	NA	NA	NA
AYG27380.1\|1039582_1040563_-	ribose-phosphate diphosphokinase	A0A2K9L8D8	Tupanvirus	4.9e-42	36.3
AYG27381.1\|1040928_1041753_-	serine hydrolase	NA	NA	NA	NA
AYG27382.1\|1041988_1043371_-	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	A0A2K9L140	Tupanvirus	5.7e-28	33.2
AYG27383.1\|1043439_1044276_-	pur operon repressor	NA	NA	NA	NA
AYG27384.1\|1044768_1045032_-	hypothetical protein	NA	NA	NA	NA
AYG27385.1\|1045046_1045589_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
AYG27386.1\|1046138_1046414_-	hypothetical protein	NA	NA	NA	NA
AYG27387.1\|1046769_1047573_-	metal ABC transporter permease	NA	NA	NA	NA
AYG27388.1\|1047559_1048258_-	ABC transporter ATP-binding protein	A0A1V0SGN0	Hokovirus	1.2e-15	27.8
AYG27389.1\|1048525_1049470_-	alpha/beta hydrolase	NA	NA	NA	NA
AYG27390.1\|1049779_1050646_-	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
AYG27391.1\|1050778_1051030_-	hypothetical protein	NA	NA	NA	NA
AYG27392.1\|1051134_1052025_-	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	NA	NA	NA	NA
AYG27393.1\|1052021_1052585_-	ribonuclease M5	NA	NA	NA	NA
AYG27394.1\|1052571_1053348_-	TatD family deoxyribonuclease	NA	NA	NA	NA
AYG27395.1\|1053732_1054508_-\|transposase	IS5-like element ISLpl3 family transposase	A0A0N9SHJ4	Paenibacillus_phage	2.1e-27	53.2
AYG27396.1\|1054532_1054943_-	hypothetical protein	NA	NA	NA	NA
AYG27397.1\|1055505_1056396_+	transcriptional regulator	NA	NA	NA	NA
AYG27398.1\|1056429_1057614_-	Bcr/CflA family efflux MFS transporter	NA	NA	NA	NA
AYG27399.1\|1057943_1058270_-	hypothetical protein	NA	NA	NA	NA
AYG27400.1\|1058748_1060800_-\|tRNA	methionine--tRNA ligase	A0A1V0SHR2	Klosneuvirus	2.7e-90	35.8
AYG27401.1\|1061121_1061511_-	NUDIX domain-containing protein	NA	NA	NA	NA
AYG27402.1\|1062105_1062948_-	DUF72 domain-containing protein	NA	NA	NA	NA
AYG27403.1\|1062947_1063652_-	NAD-dependent protein deacetylase	NA	NA	NA	NA
AYG27404.1\|1063673_1064633_-	IpaB/EvcA family protein	NA	NA	NA	NA
AYG27405.1\|1064625_1065900_-	hydroxymethylglutaryl-CoA reductase, degradative	NA	NA	NA	NA
AYG27406.1\|1065945_1066863_-	Ppx/GppA family phosphatase	NA	NA	NA	NA
AYG27407.1\|1067262_1068276_-\|tRNA	tRNA-dihydrouridine synthase family protein	NA	NA	NA	NA
AYG27408.1\|1068388_1069135_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
AYG27409.1\|1069284_1070181_-	ROK family protein	NA	NA	NA	NA
AYG27410.1\|1070301_1071738_-	glycosyl hydrolase family protein	A0A0B5JD41	Pandoravirus	9.7e-31	25.5
AYG29332.1\|1071755_1073111_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
AYG27411.1\|1073333_1073756_-	DUF3284 domain-containing protein	NA	NA	NA	NA
AYG27412.1\|1073745_1073934_-	hypothetical protein	NA	NA	NA	NA
AYG27413.1\|1073940_1075302_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
AYG27414.1\|1075374_1076085_-	GntR family transcriptional regulator	NA	NA	NA	NA
AYG27415.1\|1076490_1077507_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
AYG27416.1\|1077940_1078717_-	carbon-nitrogen family hydrolase	NA	NA	NA	NA
AYG27417.1\|1078975_1081285_+	ATP-dependent DNA helicase	NA	NA	NA	NA
AYG27418.1\|1081379_1081583_-	hypothetical protein	NA	NA	NA	NA
AYG27419.1\|1081720_1082407_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AYG27420.1\|1082500_1083181_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AYG27421.1\|1083267_1083936_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AYG27422.1\|1084003_1084693_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AYG27423.1\|1084779_1086159_-	HlyD family secretion protein	NA	NA	NA	NA
AYG27424.1\|1088610_1089534_+\|transposase	IS30 family transposase	H7BVY4	unidentified_phage	6.7e-33	31.9

DBSCAN-SWA_6

1772706 : 1782074

Planktothrix_phage(16.67%)

bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG28017.1\|1772706_1774728_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.5e-18	30.5
AYG28018.1\|1774820_1775798_-	guanosine monophosphate reductase	Q4ZCY7	Staphylococcus_virus	1.4e-137	71.2
AYG28019.1\|1775840_1777130_-	adenylosuccinate synthetase	L7Y4J5	Megavirus	3.5e-72	37.0
AYG28020.1\|1777446_1778745_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.8e-18	33.6
AYG28021.1\|1778967_1779297_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
AYG28022.1\|1779491_1780826_-	NAD(P)/FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	7.9e-27	27.1
AYG28023.1\|1780961_1782074_+	glycerate kinase	W6LM47	Streptococcus_phage	1.3e-35	35.3

DBSCAN-SWA_7

2265831 : 2274345

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG28432.1\|2265831_2266317_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.3e-16	41.0
AYG28433.1\|2266300_2267431_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AYG28434.1\|2267433_2268165_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4SM18	Cyanophage	1.2e-37	38.6
AYG28435.1\|2268166_2268421_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AYG28436.1\|2268420_2269101_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AYG28437.1\|2269093_2271313_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-143	38.9
AYG28438.1\|2271297_2272752_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	7.3e-50	33.8
AYG28439.1\|2272748_2273774_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	1.2e-59	41.0
AYG28440.1\|2273766_2274345_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-21	33.9

DBSCAN-SWA_8

2470562 : 2509575

Lactobacillus_phage(54.17%)

integrase,portal,holin,plate,terminase,capsid,tail

attL 2467854:2467871|attR 2477628:2477645

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2467854:2467871	attL	NA	NA	NA	NA
AYG28618.1\|2470562_2471684_-\|integrase	site-specific integrase	D6PSS4	Lactobacillus_phage	9.9e-47	32.4
AYG28619.1\|2471932_2473126_-	hypothetical protein	A0A141E0C6	Streptococcus_phage	5.4e-19	25.9
AYG28620.1\|2473745_2474447_-	DUF3862 domain-containing protein	A0A0P0IXE0	Lactobacillus_phage	2.0e-05	80.8
AYG28621.1\|2474554_2474809_-	hypothetical protein	NA	NA	NA	NA
AYG28622.1\|2474818_2475610_-	hypothetical protein	NA	NA	NA	NA
AYG29363.1\|2476081_2476780_-	hypothetical protein	NA	NA	NA	NA
AYG28623.1\|2476964_2477933_-	DUF5067 domain-containing protein	NA	NA	NA	NA
2477628:2477645	attR	NA	NA	NA	NA
AYG28624.1\|2477988_2478411_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
AYG28625.1\|2478425_2478944_-	XRE family transcriptional regulator	S6C481	Thermus_phage	1.6e-15	34.1
AYG28626.1\|2479085_2479274_+	XRE family transcriptional regulator	NA	NA	NA	NA
AYG28627.1\|2479355_2480168_+	hypothetical protein	A0A0P0IZH9	Lactobacillus_phage	1.2e-73	49.6
AYG28628.1\|2480248_2481157_+	DnaD domain protein	NA	NA	NA	NA
AYG28629.1\|2481153_2481441_+	hypothetical protein	NA	NA	NA	NA
AYG28630.1\|2481437_2481956_+	hypothetical protein	O03915	Lactobacillus_phage	3.5e-55	68.4
AYG28631.1\|2481952_2482333_+	hypothetical protein	NA	NA	NA	NA
AYG28632.1\|2482543_2483005_+	transcriptional regulator	D6PSV8	Lactobacillus_phage	1.1e-39	57.0
AYG28633.1\|2483269_2483887_-	hypothetical protein	NA	NA	NA	NA
AYG28634.1\|2484782_2484980_+	hypothetical protein	NA	NA	NA	NA
AYG28635.1\|2484957_2485134_+	hypothetical protein	E9LUP6	Lactobacillus_phage	9.1e-08	57.4
AYG28636.1\|2485102_2485360_+	hypothetical protein	A0A0N9SKC5	Staphylococcus_phage	1.3e-15	47.6
AYG28637.1\|2485413_2485953_+\|terminase	terminase small subunit	O03926	Lactobacillus_phage	1.0e-49	75.3
AYG28638.1\|2485933_2487259_+\|terminase	PBSX family phage terminase large subunit	A0A1S5SA45	Streptococcus_phage	4.5e-139	55.7
AYG28639.1\|2487306_2488857_+\|portal	phage portal protein	B5LPR1	Bacillus_virus	8.2e-84	38.2
AYG28640.1\|2488849_2489044_+	hypothetical protein	NA	NA	NA	NA
AYG28641.1\|2489040_2489934_+	hypothetical protein	A0A1B1P858	Bacillus_phage	2.1e-36	35.3
AYG28642.1\|2489997_2490609_+	hypothetical protein	NA	NA	NA	NA
AYG28643.1\|2490622_2491570_+\|capsid	N4-gp56 family major capsid protein	A8ASJ6	Listeria_phage	4.4e-88	59.1
AYG28644.1\|2491929_2492334_+	hypothetical protein	A5GYM1	Lactococcus_phage	2.0e-05	27.5
AYG28645.1\|2492334_2492724_+	hypothetical protein	NA	NA	NA	NA
AYG28646.1\|2492720_2493122_+	hypothetical protein	NA	NA	NA	NA
AYG28647.1\|2493121_2493547_+	hypothetical protein	NA	NA	NA	NA
AYG28648.1\|2493564_2494173_+	hypothetical protein	NA	NA	NA	NA
AYG28649.1\|2494291_2494810_+	hypothetical protein	NA	NA	NA	NA
AYG28650.1\|2494806_2495448_+	hypothetical protein	U3PFU8	Lactobacillus_phage	1.3e-06	27.5
AYG28651.1\|2495463_2501112_+\|tail	phage tail tape measure protein	Q5ULL6	Lactobacillus_virus	3.6e-36	70.0
AYG28652.1\|2501112_2501931_+\|tail	phage tail family protein	NA	NA	NA	NA
AYG28653.1\|2501942_2503070_+	hypothetical protein	O03938	Lactobacillus_phage	3.1e-72	42.0
AYG28654.1\|2503062_2503311_+	hypothetical protein	NA	NA	NA	NA
AYG28655.1\|2503285_2503639_+	hypothetical protein	NA	NA	NA	NA
AYG29364.1\|2504135_2504939_+	SGNH/GDSL hydrolase family protein	Q597U1	Lactobacillus_virus	1.4e-127	84.3
AYG28656.1\|2504952_2505507_+\|plate	phage baseplate upper protein	O03968	Lactobacillus_phage	4.9e-55	61.8
AYG28657.1\|2505503_2507339_+	hypothetical protein	Q597U3	Lactobacillus_virus	7.5e-185	52.4
AYG28658.1\|2507350_2507620_+	hypothetical protein	NA	NA	NA	NA
AYG28659.1\|2507612_2507744_+	XkdX family protein	NA	NA	NA	NA
AYG28660.1\|2507759_2508914_+	LysM peptidoglycan-binding domain-containing protein	O03950	Lactobacillus_phage	2.6e-42	37.5
AYG28661.1\|2508914_2509211_+	hypothetical protein	A0A1I9KK55	Lactobacillus_phage	1.2e-39	77.6
AYG28662.1\|2509197_2509575_+\|holin	holin	A0A2K9VCG4	Lactobacillus_phage	4.1e-21	77.5

DBSCAN-SWA_9

2798863 : 2881183

Lactobacillus_phage(79.59%)

portal,tail,protease,holin,terminase,head,tRNA,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYG28922.1\|2798863_2799226_-	hypothetical protein	E9LUS2	Lactobacillus_phage	2.1e-59	95.8
AYG28923.1\|2799382_2799571_-	hypothetical protein	E9LUS5	Lactobacillus_phage	2.1e-26	100.0
AYG28924.1\|2799888_2800089_-	hypothetical protein	E9LUS6	Lactobacillus_phage	5.5e-25	97.0
AYG28925.1\|2800270_2800969_-	hypothetical protein	Q9AZW5	Lactococcus_phage	2.1e-18	36.8
AYG28926.1\|2800977_2801364_-	hypothetical protein	NA	NA	NA	NA
AYG29374.1\|2801421_2801700_-	hypothetical protein	D2KRD5	Lactobacillus_phage	1.3e-21	59.3
AYG28927.1\|2801709_2802048_-	XRE family transcriptional regulator	Q8W5Y0	Listeria_phage	1.0e-15	42.2
AYG28928.1\|2802293_2802515_+	hypothetical protein	NA	NA	NA	NA
AYG29375.1\|2802520_2803228_+	phage regulatory protein	D2IYT0	Enterococcus_phage	6.8e-70	62.2
AYG28929.1\|2803239_2803449_+	hypothetical protein	NA	NA	NA	NA
AYG28930.1\|2803564_2803891_-	RNA polymerase III	E9LUT2	Lactobacillus_phage	2.7e-53	98.1
AYG28931.1\|2803948_2804209_+	hypothetical protein	NA	NA	NA	NA
AYG28932.1\|2804351_2804600_+	tagatose-bisphosphate aldolase	E9LUT6	Lactobacillus_phage	1.9e-35	84.1
AYG28933.1\|2804602_2804803_+	hypothetical protein	E9LUT7	Lactobacillus_phage	1.7e-26	89.4
AYG28934.1\|2804814_2805039_+	hypothetical protein	E9LUT8	Lactobacillus_phage	1.2e-28	86.3
AYG28935.1\|2805257_2805515_+	hypothetical protein	NA	NA	NA	NA
AYG28936.1\|2805619_2806423_+	replisome organizer	E9LUM6	Lactobacillus_phage	6.4e-40	56.9
AYG28937.1\|2806416_2807292_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	2.2e-49	41.6
AYG28938.1\|2807754_2808066_+	hypothetical protein	A0A2P0ZLB4	Lactobacillus_phage	3.0e-46	87.4
AYG28939.1\|2809027_2809429_+	hypothetical protein	K4I239	Lactobacillus_phage	5.5e-32	54.5
AYG28940.1\|2809501_2809927_+	DUF1642 domain-containing protein	E9LUP3	Lactobacillus_phage	2.2e-39	61.7
AYG28941.1\|2810429_2810858_+	transcriptional regulator	E9LUP5	Lactobacillus_phage	1.1e-65	86.5
AYG28942.1\|2811191_2811371_+	hypothetical protein	E9LUP6	Lactobacillus_phage	3.1e-19	86.4
AYG28943.1\|2811339_2811849_+	HNH endonuclease	E9LUP7	Lactobacillus_phage	2.2e-78	91.5
AYG28944.1\|2812045_2812501_+\|terminase	phage terminase small subunit P27 family	E9LUP8	Lactobacillus_phage	9.4e-81	97.4
AYG28945.1\|2812510_2814409_+\|terminase	terminase large subunit	E9LUP9	Lactobacillus_phage	0.0e+00	94.0
AYG28946.1\|2814398_2814593_+	DUF1056 family protein	E9LUQ0	Lactobacillus_phage	3.7e-26	93.8
AYG28947.1\|2814595_2815789_+\|portal	phage portal protein	E9LUQ1	Lactobacillus_phage	3.1e-224	98.7
AYG28948.1\|2815766_2816522_+\|protease	Clp protease ClpP	E9LUQ2	Lactobacillus_phage	3.9e-124	93.2
AYG28949.1\|2816521_2817754_+\|capsid	phage major capsid protein	E9LUQ3	Lactobacillus_phage	4.3e-213	94.1
AYG28950.1\|2817826_2818165_+\|head,tail	phage gp6-like head-tail connector protein	E9LUQ4	Lactobacillus_phage	5.8e-51	91.1
AYG28951.1\|2818148_2818511_+\|head,tail	head-tail adaptor protein	E9LUQ5	Lactobacillus_phage	6.4e-64	97.5
AYG28952.1\|2818500_2818941_+\|tail	phage tail protein	E9LUQ6	Lactobacillus_phage	4.2e-78	97.9
AYG28953.1\|2818937_2819321_+	DUF806 family protein	E9LUQ7	Lactobacillus_phage	1.0e-64	96.9
AYG28954.1\|2819321_2819960_+\|tail	phage tail protein	E9LUQ8	Lactobacillus_phage	1.4e-109	93.9
AYG28955.1\|2820161_2820545_+	hypothetical protein	E9LUQ9	Lactobacillus_phage	2.0e-63	99.2
AYG28956.1\|2820541_2820733_+	hypothetical protein	E9LUR0	Lactobacillus_phage	1.5e-27	98.4
AYG28957.1\|2820745_2825968_+\|tail	phage tail protein	E9LUR1	Lactobacillus_phage	0.0e+00	76.9
AYG28958.1\|2826039_2827812_+\|tail	phage tail protein	E9LUR2	Lactobacillus_phage	0.0e+00	96.6
AYG28959.1\|2827878_2830248_+	hypothetical protein	E9LUR3	Lactobacillus_phage	0.0e+00	92.9
AYG28960.1\|2830264_2833063_+\|tail	phage tail protein	E9LUR4	Lactobacillus_phage	3.1e-222	73.2
AYG28961.1\|2833055_2833298_+	hypothetical protein	A0A2K9VDF6	Lactobacillus_phage	6.2e-31	92.5
AYG28962.1\|2833446_2834544_+	collagen-like protein	A0A2P0ZLF6	Lactobacillus_phage	8.1e-62	87.1
AYG28963.1\|2834540_2834753_+	hypothetical protein	A0A0A1ENR9	Lactobacillus_phage	2.0e-17	80.3
AYG28964.1\|2834764_2835943_+	LysM peptidoglycan-binding domain-containing protein	E9LUR8	Lactobacillus_phage	6.9e-200	89.0
AYG28965.1\|2835942_2836206_+\|holin	holin	E9LUR9	Lactobacillus_phage	2.0e-38	100.0
AYG28966.1\|2836215_2836590_+\|holin	holin	A0A2K9VCG4	Lactobacillus_phage	2.6e-20	76.2
AYG28967.1\|2837377_2838589_+	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
AYG28968.1\|2840828_2841620_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.5e-30	36.8
AYG28969.1\|2841600_2842785_+	LytR family transcriptional regulator	NA	NA	NA	NA
AYG28970.1\|2842936_2843509_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AYG28971.1\|2844208_2845150_-	glycosyltransferase	V9QJB1	Oenococcus_phage	3.1e-78	48.7
AYG28972.1\|2845595_2845988_-	hypothetical protein	NA	NA	NA	NA
AYG28973.1\|2846151_2846544_+	hypothetical protein	NA	NA	NA	NA
AYG28974.1\|2846579_2847749_+	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
AYG28975.1\|2847798_2848428_-	hypothetical protein	NA	NA	NA	NA
AYG28976.1\|2848731_2848962_+	hypothetical protein	NA	NA	NA	NA
AYG28977.1\|2849051_2849684_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	2.3e-16	56.2
AYG28978.1\|2849835_2850075_+	DUF896 domain-containing protein	NA	NA	NA	NA
AYG28979.1\|2850172_2850409_+	YneF family protein	NA	NA	NA	NA
AYG28980.1\|2850465_2851101_-	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
AYG28981.1\|2851212_2851971_+\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
AYG28982.1\|2851954_2852260_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
AYG28983.1\|2852344_2853343_+	D-2-hydroxyacid dehydrogenase	M1HKI4	Acanthocystis_turfacea_Chlorella_virus	2.3e-47	34.9
AYG28984.1\|2853632_2854355_-	HAD family hydrolase	NA	NA	NA	NA
AYG28985.1\|2854579_2855383_+	30S ribosomal protein S2	NA	NA	NA	NA
AYG28986.1\|2855485_2856364_+	elongation factor Ts	NA	NA	NA	NA
AYG28987.1\|2856563_2857286_+	UMP kinase	NA	NA	NA	NA
AYG28988.1\|2857287_2857851_+	ribosome-recycling factor	NA	NA	NA	NA
AYG28989.1\|2857970_2858750_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	1.8e-23	43.1
AYG28990.1\|2858765_2859551_+	CDP-archaeol synthase	NA	NA	NA	NA
AYG28991.1\|2859588_2860866_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
AYG28992.1\|2860905_2862615_+\|tRNA	proline--tRNA ligase	NA	NA	NA	NA
AYG28993.1\|2863108_2867422_+	DNA polymerase III subunit alpha	A0A1X9SH08	Bradyrhizobium_phage	1.0e-14	34.0
AYG28994.1\|2867717_2868194_+	ribosome maturation factor RimP	NA	NA	NA	NA
AYG28995.1\|2868214_2869432_+	transcription termination/antitermination protein NusA	NA	NA	NA	NA
AYG28996.1\|2869476_2869776_+	YlxR family protein	NA	NA	NA	NA
AYG28997.1\|2869765_2870071_+	hypothetical protein	NA	NA	NA	NA
AYG28998.1\|2870085_2872662_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	9.6e-21	23.3
AYG28999.1\|2872684_2873038_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
AYG29000.1\|2873686_2875141_+	MFS transporter	NA	NA	NA	NA
AYG29001.1\|2875133_2876303_+	chorismate synthase	NA	NA	NA	NA
AYG29002.1\|2876311_2876839_+	amino acid biosynthesis protein	NA	NA	NA	NA
AYG29003.1\|2876852_2878151_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
AYG29004.1\|2878153_2879251_+	prephenate dehydrogenase	NA	NA	NA	NA
AYG29005.1\|2879253_2879775_+	shikimate kinase	NA	NA	NA	NA
AYG29006.1\|2880259_2881183_+\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP032649

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP032648

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection