CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP019857	Clostridioides difficile strain DSM 29745 chromosome, complete genome	12 crisprs	WYL,cas3,DEDDh,cas14j,DinG,csa3,c2c9_V-U4,RT,cas14k,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2,PD-DExK	0	33	12	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP019857_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_1

146625-146703

Orphan

Consensus_repeat	Method
TGTTTATAATGTGGATAATATTTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP019857_1

>merge|CP019857|1|146625-146703|CRISPRCasFinder
TGTTTATAATGTGGATAATATTTAATGTAATAAGTTAAAGCAATATGAATCAACTGTTTATAATGTGGATAATATTATA

>CP019857|1|1|146625-146703|CRISPRCasFinder
TGTTTATAATGTGGATAATATTTAA	TGTAATAAGTTAAAGCAATATGAATCAAC
TGTTTATAATGTGGATAATATTATA

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU85096.1\|167107_168454_+\|phosphoglucomutase/phosphomannomutase-mutase	unknown	unknown	gnl\|CDD\|237670
CP019857.1\|AXU85089.1\|161591_162494_+\|phosphate-butyryltransferase	unknown	unknown	gnl\|CDD\|180267
CP019857.1\|AXU85093.1\|164548_165628_+\|2-ketoisovalerate-ferredoxin-reductase	unknown	unknown	gnl\|CDD\|235942
CP019857.1\|AXU85078.1\|124534_125401_+\|cobalt-transporter-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|237455
CP019857.1\|AXU85082.1\|127540_127933_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
CP019857.1\|AXU85091.1\|163584_164262_+\|ATP/GTP-binding-protein	unknown	unknown	unknown
CP019857.1\|AXU85088.1\|160106_161288_+\|membrane-associated-protein	unknown	unknown	gnl\|CDD\|227193
CP019857.1\|AXU85095.1\|166380_166938_+\|subunit-of-oxidoreductase	unknown	unknown	gnl\|CDD\|376567
CP019857.1\|AXU85085.1\|143231_145583_+\|anaerobic-ribonucleoside-triphosphate-reductase	unknown	unknown	gnl\|CDD\|235937
CP019857.1\|AXU85087.1\|159270_160110_+\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|224539
CP019857.1\|AXU85090.1\|162515_163595_+\|butyrate-kinase	unknown	unknown	gnl\|CDD\|235099
CP019857.1\|AXU85086.1\|145604_146144_+\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	unknown	unknown	gnl\|CDD\|274161
CP019857.1\|AXU85084.1\|141674_142859_-\|aspartate-aminotransferase	unknown	unknown	gnl\|CDD\|235596
CP019857.1\|AXU85081.1\|127080_127512_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
CP019857.1\|AXU85080.1\|126229_126961_+\|tRNA-pseudouridine-synthase-1	unknown	unknown	gnl\|CDD\|234577
CP019857.1\|AXU85083.1\|128391_129144_+\|germination-specific-N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|274337
CP019857.1\|AXU85077.1\|123713_124547_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|275313
CP019857.1\|AXU85092.1\|164304_164520_+\|ferredoxin	unknown	unknown	gnl\|CDD\|225131
CP019857.1\|AXU85094.1\|165627_166380_+\|subunit-of-oxidoreductase	unknown	unknown	gnl\|CDD\|239470
CP019857.1\|AXU85079.1\|125394_126198_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223692

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU85096.1\|167107_168454_+\|phosphoglucomutase/phosphomannomutase-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
CP019857.1\|AXU85089.1\|161591_162494_+\|phosphate-butyryltransferase	gnl\|CDD\|180267	PRK05805, PRK05805, phosphate butyryltransferase; Validated.	1.26101e-179
CP019857.1\|AXU85093.1\|164548_165628_+\|2-ketoisovalerate-ferredoxin-reductase	gnl\|CDD\|235942	PRK07119, PRK07119, 2-ketoisovalerate ferredoxin reductase; Validated.	0
CP019857.1\|AXU85078.1\|124534_125401_+\|cobalt-transporter-ATP-binding-subunit	gnl\|CDD\|237455	PRK13637, cbiO, energy-coupling factor transporter ATPase.	0
CP019857.1\|AXU85082.1\|127540_127933_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	3.31674e-84
CP019857.1\|AXU85094.1\|165627_166380_+\|subunit-of-oxidoreductase	gnl\|CDD\|239470	cd03375, TPP_OGFOR, Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA. In the reductive tricarboxylic acid cycle found in the anaerobic autotroph Hydrogenobacter thermophilus, OGFOR catalyzes the reductive carboxylation of succinyl-CoA to produce 2-oxoglutarate. Thauera aromatica OGFOR has been shown to provide reduced ferredoxin to benzoyl-CoA reductase, a key enzyme in the anaerobic metabolism of aromatic compounds. OGFOR is dependent on TPP and a divalent metal cation for activity.	1.15077e-77
CP019857.1\|AXU85088.1\|160106_161288_+\|membrane-associated-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	1.22215e-23
CP019857.1\|AXU85095.1\|166380_166938_+\|subunit-of-oxidoreductase	gnl\|CDD\|376567	pfam01558, POR, Pyruvate ferredoxin/flavodoxin oxidoreductase. This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyzes the final step in the fermentation of carbohydrates in anaerobic microorganisms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited.	1.49735e-43
CP019857.1\|AXU85085.1\|143231_145583_+\|anaerobic-ribonucleoside-triphosphate-reductase	gnl\|CDD\|235937	PRK07111, PRK07111, anaerobic ribonucleoside triphosphate reductase; Provisional.	0
CP019857.1\|AXU85087.1\|159270_160110_+\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	1.4029e-80
CP019857.1\|AXU85090.1\|162515_163595_+\|butyrate-kinase	gnl\|CDD\|235099	PRK03011, PRK03011, butyrate kinase; Provisional.	0
CP019857.1\|AXU85086.1\|145604_146144_+\|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein	gnl\|CDD\|274161	TIGR02491, Anaerobic_ribonucleoside-triphosphate_reductase, anaerobic ribonucleoside-triphosphate reductase activating protein. This enzyme is a member of the radical-SAM family (pfam04055) and utilizes S-adenosyl methionine, an iron-sulfur cluster and a reductant (dihydroflavodoxin) to produce a glycine-centered radical in the class III (anaerobic) ribonucleotide triphosphate reductase (NrdD, TIGR02487). The two components form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism, Protein fate, Protein modification and repair].	3.78376e-50
CP019857.1\|AXU85084.1\|141674_142859_-\|aspartate-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	2.82682e-180
CP019857.1\|AXU85081.1\|127080_127512_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	1.05591e-98
CP019857.1\|AXU85080.1\|126229_126961_+\|tRNA-pseudouridine-synthase-1	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	6.63504e-129
CP019857.1\|AXU85083.1\|128391_129144_+\|germination-specific-N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|274337	TIGR02883, spore_cwlD, N-acetylmuramoyl-L-alanine amidase CwlD. Members of this protein family are the CwlD family of N-acetylmuramoyl-L-alanine amidase. This family has been called the germination-specific N-acetylmuramoyl-L-alanine amidase. CwlD is required, along with the putative deactylase PdaA, to make muramic delta-lactam, a novel peptidoglycan constituent found only in spores. CwlD mutants show a germination defect. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	1.1235e-78
CP019857.1\|AXU85077.1\|123713_124547_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|275313	TIGR04520, ECF_ATPase_1, energy-coupling factor transporter ATPase. Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate].	2.34653e-173
CP019857.1\|AXU85092.1\|164304_164520_+\|ferredoxin	gnl\|CDD\|225131	COG2221, DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion].	6.6539e-10
CP019857.1\|AXU85079.1\|125394_126198_+\|ABC-transporter-permease	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.3503e-50

>CP019857.1|AXU85086.1|145604_146144_+|anaerobic-ribonucleoside-triphosphate-reductase-activating-protein
MKIRMSSTISYDSIVDGPGLRMVIWTQGCIHNCKECHNPQTHDLCGGFYMDTEEIINKVKSLKLQKGITLSGGEPFLQPEPLEEIAREAKINGLDVWSYTGFTFEQLLDKKNRAYFKNLNLLKQIDILVDGKFIAEKKDISLKFRGSSNQRIIDVQKSLKYKKVFLVEQYMKDDLSIAE
>CP019857.1|AXU85085.1|143231_145583_+|anaerobic-ribonucleoside-triphosphate-reductase
MVEFVKKRDGRVIPFNEDRITRAIFLAATNVAEREGIVPDYKLSEQLTQEVIKFLNHKYSESVPSVEDIQDSVVKVLIETGHAKTSEEYIIYRTERSRIRNSKTRLMKAIEEITFEDAEDADIKRENANINGNTAMGTMLQYGSTVSKEFCKTHILKPEHSFAHDNGDIHIHDMDFLNMGTLTCCQIDVKKLFNGGFSTGHGFLREPQDIISYGALAAIAIQSNQNDQHGGQSIPFFDYGLAEGVYKTFKKFYIGNLAKALKLFKGIENNDVIKNIVYNTEKETNQKVGLKRDELYLNLEKEKLIQTFDIDDELVNKMQNFAFEESYRETDKKTYQSMEAFIHNLNTMHSRAGAQVPFSSVNFGTDTSEEGRMVTKNLLLSQERGLGNGETPIFPILIFKVKEGINLNPEDPNYDLFKLSCRVSAKRLFPNFSFLDAPFNAKYYKKGEPDTEATYMGCRTRVLSNVCGSETVSGRGNISFTTVNLPRLGIKHGIINNEKANLDGFFEELDEKINLIIEQLLERLEVQGNKKMKNFPFLMGQGVWKGSDNLGPEDTLKEVIKQGTLTIGFIGLAECLIALIGKHHGESKEAQELGLKIVSHMRHKMDEATDKYKLNFSLMGTPAEGLSGRFTKIDKKVYGEIKGITDKEYYTNSFHVPVYYNISAYDKIEIEAPYHELTNAGHITYVELDGDPSDNLEAFETVIKAMKDLGIGYGSINHPVDRDPICGFSGVITSNICPVCGRNEDESDIKFERIRRITGYLVGTVDRFNNAKKAEVRDRVKHR
>CP019857.1|AXU85084.1|141674_142859_-|aspartate-aminotransferase
MLSKRLNFITPSYTIGISSKVKEMESNGVKVINLSIGEPDFNVPNNAKSYGIDSLNKDYTKYDLVPGLKILREEICKKLIEENNCNYSIDEIVVSSGAKNSITNTLLALTDEGDEVLLPKPYWVSYPEMIKLVNAVPVFIDTKKENGFKLTKEELEKSITDKTKILVINNPSNPTGSVYTKDELIEIVDVCIQNKIYILADEIYEKICYTGEFTSIASLSEEAKDITITINGFSKSAAMTGLRLGYTASNKTIAKAMSSIQGHLISHPSLTAQYIAYGALKDCSIDIDNMVKTYKSRRDLIKSKLDSIDNVGYVNPNGAFYIFIDLSKVSEKFEYKDSFSIEFCNQFLEEYNVAVVPGIAFGMDKYIRISYACSENTFLSGLDKLKEFVYKIMA
>CP019857.1|AXU85083.1|128391_129144_+|germination-specific-N-acetylmuramoyl-L-alanine-amidase
MEYYGVFISIHIQGDVVRKYIKHIIFSFAMICLVVVSIFEIKNISEDVIKYMPVTNKTIILDAGHGGIDPGALNKDKSTSEKDINLAITLKLRELIESSGGLVILTREDDSSLYKEENNKTTRQKYNENLKNRKEIISNSNANMFVSIHLNAFEQSKYYGAQTFYPKDKQDSKALSKCIQEELKRVVDKTNNREVKPRDDIYLLKENNIPSVLIECGFLSNEKECKLLTDETYQEKIAWAIYIGIQKYLS
>CP019857.1|AXU85082.1|127540_127933_+|30S-ribosomal-protein-S9
MANVQYYGTGRRKSSVARVRLVAGEGNILVNGRALENYFNYETLIRDVKQPLVLTGNENKYDVIVKVEGGGFTGQAGAIRHGISRALLKADLDLRPALKKEGFLTRDARMKERKKYGLKAARRAPQFSKR
>CP019857.1|AXU85081.1|127080_127512_+|50S-ribosomal-protein-L13
MKSYIAKPADVQRKWYLVDAEGKTLGRLATEIATVLRGKHKPTFTPHVDGGDFVVVVNAEKIVLSGKKLDQKYYRYHTGYVGGLKEISYRDMMDKKPEEVISHAVSGMLPKNKLRSRMMTRLRVFAGAEHTHAAQNPEVLNFK
>CP019857.1|AXU85080.1|126229_126961_+|tRNA-pseudouridine-synthase-1
MRNIKIKIQYNGKNYCGWQKQPDSLGIQGTIERAIYDITKEETSLIGSGRTDSGVHAIGQIANFKINSGISIESIPMALNAKLPKDISVIEACEVNDDFHSRYSAKGKTYKYLVYNSKFRNPILSEISYQVKYELDFDKMCSEAKSLLGTHDFKGFMSSGSSVKDTVRTIYDIDISKKDDLITFEISGNGFLYNMVRIIVGTLVDMGRGRINEPFLDIIQSKTRSRCGHTAPAQGLFLKKVHY
>CP019857.1|AXU85079.1|125394_126198_+|ABC-transporter-permease
MLKDITIGQYYPTSSAIHKLDPRIKLVATIVFMVSIFVVNKFWPYIVVLLCLLAMIKLANIPVKYIVKGVKPLKWIILFTFLINIFFLPGDEIWSFGFLAITKQGLRQAIFMAIRLIFLVVGTSLLTLTTSPIELTDGIERLLNPFKKIGLPVHELAMMMTIALRFIPTLLDETDKIMKAQMSRGADFESKNLINRAKNLVPLLVPLFVSAFRRADELAMAMEARCYRGGHNRTKMRESVISRRDYMACVFQVVYLGAIIATRFIAI
>CP019857.1|AXU85078.1|124534_125401_+|cobalt-transporter-ATP-binding-subunit
MSIIVKNLTHIYNEGMPFASKALDDVSFEIKDRDFVGLIGHTGSGKSTLIQHLNGLLKPSSGEIFINDFNITDKNLNLTEIRKRVGVVFQYPEYQLFEETIDKDIAFGPSNLGLEESEIHNRVKASMEAVGLDYEGFKDKSPFELSGGQKRRVAIAGVIAMNPEVLILDEPTAGLDPGGRDEIFNLIKDLHEKKNMTIILSSHSMDDMAKLAKTLIVMNHGSVEFMGTPREVFKSNASKLKDIGLDIPQVLELALKLREKGFDISEDILTLEEAKQEILKVVRGRGLC
>CP019857.1|AXU85077.1|123713_124547_+|ABC-transporter-ATP-binding-protein
MDNIVKVNNISFEYITDEAKLKAIDNLSLDVKKGEFVAIIGHNGSGKSTLSKNLNAILMPTEGNILIDDMDTKEEERLWDIRQTAGMVFQNPDNQIVATIVEEDVAFGPENLGIEPKEIRRIVEESLKSVGMYDLRDRQPHLLSGGQKQRVAIAGIIAMRPKCIIFDEATAMLDPSGRKEVMKTIKRLNKEENITVIHITHFMEEAVEADRVVVMEKGKKILEGTPREVFSKIKMLKEIGLDVPCMTELSSLLIEEGINISSDILTVDEMVMELCQL
>CP019857.1|AXU85087.1|159270_160110_+|DNA-integrity-scanning-protein-DisA
MLDINSFLNGFFNIILRMSIYDLIDISIVAYIFYKIFMFIKDTRAEQVFKGIIFLLLATQLSNTFKLHTVYWISLKALDYGVIAALIIFQPEFRAGLEHIGRAKFNLFGKNVNTSEETLNRNIEEIVEALYSLSRQKIGALIIMERETRISDIINTGTIIDAEISRQLLINIFIPNTPLHDGAVVIRDSKVKAAACFLPLTESKDLSKDLGTRHRAGIGVSEVSDCITLIVSEETGGVSIAKAGKLYRDISRERMMNILRSNLKTNTETRSFFKGGIFK
>CP019857.1|AXU85088.1|160106_161288_+|membrane-associated-protein
MINRLKNNTKIKIISFLSAIALWMYVMAVVDPEETKGFEDIPVSISNMSDLKDKNLVIYPDEKLTADVYIKGSLSKVQSVKKEDIHVYGTIEDPIQGQKEVYLKANIPQGVTLEFKHDVLVVNLEKNIKEKRDIKVEVSGNSKRNINKIELSKEFVDVSGPRTLVKEVKSVRANLDVGNETDDFSKKLQLIPLNSDGTKVEGVTLSSSFVTAKIELLKEKIVPIRVSLNDNKDNDVLKNYKLSKEQVTIKGKKEDIDKISYIKTKPIDLADLANGEEKEVSLEIPEGITLEDSSITIKLNDTKQLSAEFLYNAGDIELRNIPTNMDNPNVISDVDIKVVVESTEDLSKLNKKDISLYIDLSQGPEEDSKYKIKYETTYQFKKINIEPNIVEVE
>CP019857.1|AXU85089.1|161591_162494_+|phosphate-butyryltransferase
MRSFEEVIKFAKERGPKTISVACCQDKEVLMAVEMARKEKIANAILVGDIEKTKEIAKSIDMDIENYELIDIKDLAEASLKSVELVSQGKADMVMKGLVDTSIILKAVLNKEVGLRTGNVLSHVAVFDVEGYDRLFFVTDAAMNLAPDTNTKKQIIENACTVAHSLDISEPKVAAICAKEKVNPKMKDTVEAKELEEMYERGEIKGCMVGGPFAIDNAVSLEAAKHKGINHPVAGRADILLAPDIEGGNILYKALVFFSKSKNAGVIVGAKAPIILTSRADSEETKLNSIALGVLMAAKA
>CP019857.1|AXU85090.1|162515_163595_+|butyrate-kinase
MSKIFKILTINPGSTSTKIAVFDNEDLVFEKTLRHSSEEIGKYEKVSDQFEFRKQVIEEALKEGGVKTSELDAVVGRGGLLKPIKGGTYSVSAAMIEDLKVGVLGEHASNLGGIIAKQIGEEVNVPSYIVDPVVVDELEDVARISGMPEISRASVVHALNQKAIARRYAREINKKYEDINLIVAHMGGGVSVGAHKNGKIVDVANALDGEGPFSPERSGGLPVGALVKMCFSGKYTQDEIKKKIKGNGGLVAYLNTNDAREVEERIEAGDEKAKLVYEAMAYQISKEIGASAAVLKGDVKAILLTGGIAYSKMFTEMIADRVKFIADVKVYPGEDEMIALAQGGLRVLTGEEEAQVYDN
>CP019857.1|AXU85091.1|163584_164262_+|ATP/GTP-binding-protein
MITNDKRIRIITGHYGSGKSEFAMNYVVKLRDMVSGKVAIADLDVVNVYFRTREKKELMKSLGIQPIDSSINAPTLDLPAVSAEVMSPMVDHSYNSVIDLGGDNVGARVIGRFSHLLKEGDYDMLFVINANREKTQTSEEVIQYIKEIEKSSKLKVTGLINNTHLIRFTTIDDVLRGQKVAKEVSEKCNIPIRYVACLENLVEQLPKDLEGEIFPIKLYMREDWM
>CP019857.1|AXU85092.1|164304_164520_+|ferredoxin
MAKGKVSFNQERCKGCGLCVEACPVKIIQLDSNVINKKGYNPATVFEMEKCIGCASCATMCPDVVITVERD
>CP019857.1|AXU85093.1|164548_165628_+|2-ketoisovalerate-ferredoxin-reductase
MAKILMKGNEAFGKAAIEAGCKYFFGYPITPQSELPEYLSRELPKIGGAFVQAESEVSAINMVYGGAGAGARVMTSSSSPGVALKQEGITYAVGAEVPCVVLNVMRGGPGLGSIQPSQADYFMSTRGGGNGDYRTPVFAPATVQEAVDMIMEAFDVADYYRSPVMVVADGMIGQMMEPVEFRAPEKKRELPPKDWATVGTKGKRKPNVINSLYLEPEVLEDHCWHLQEKFDAMEKNEVQYEMYKTEDAEFVFAAYGTTSRVVKSAIDILREEGIKAGLIRPKVLWPFPFEAFNQIPNARNILTVEMSMGQMVEDVKMAVEGKLPVYFHGRPGGMTPTPAEIVEKAKKIIAGELVAGGAR
>CP019857.1|AXU85094.1|165627_166380_+|subunit-of-oxidoreductase
MAVVFKKTEGLQDTQTHYCPGCTHGIIHRLVGEVLEELGVLGDAVGVVPVGCSVLGYKYFNCDTQEAAHGRAPAAATGIKRVHPENTVFTYQGDGDLASIGTAEIVHAAARGEKITTIFVNNTTYGMTGGQMAPTTLVGQRATTAQSGRNAETQGYPIRVSEMLATLTGAVFVERVAVDTPAHVRQAKKAIKKAFQVQQAGLGFGIVEVLSTCPTNWGLAPNDALQWLRDNMIPYYPLGNFKNVEVEEVK
>CP019857.1|AXU85095.1|166380_166938_+|subunit-of-oxidoreductase
MSTARVICAGFGGQGVMSMGQLLTYAGMLEGKEVSWLPSYGPEMRGGTANCAVTVSNEPVGSPLITDDATAAILLNIPAFEKFKDDVIPGGKIIVNSSLIKEKVDRTDVDVYYIPANELAAELGNDKVANMIMLGAYLKVSDTVDIESVLEAFKKVFGPRKEKFVPLNREALQKGMDATCSKATN
>CP019857.1|AXU85096.1|167107_168454_+|phosphoglucomutase/phosphomannomutase-mutase
MRKYFGTDGVRGVANTELTCDLAYKLGRAGGFVLAQGDHRVKVVVGKDTRISGDMLEASLIAGLMSVGCDVITVGIIPTPAVAYLTRKYGADCGVVISASHNPVEYNGIKFFNKNGYKLDDEIELKIEEYIDDIDKIDCLPIGENVGRKLHEHCAQRDYVDYLKSIISTDFKGLKVVLDCANGASYKVAPIVFDELGASVISINSLPDGNNINYKCGSTHPEQLQRAVLEHNADLGLAYDGDADRLIAVNEKGQIVDGDHIMILSALNLKKNNKLAQDTLVVTVMSNIGLTIAAKENGINLSTTAVGDRYVLEDMVKNGYNLGGEQSGHMIFLDYNTTGDGVLSSLILANIILQEKKPLSEIASIMSQYPQVLVNATIKNENKNKYMEYPEIKTEIERIESILDGNGRVLIRPSGTEPLVRVMLEGKEEGQIKELATDLANLIQEKLS

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Crispr_ID: CP019857_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_2

1290628-1290855

Orphan

I-A

Consensus_repeat	Method
GTTTTATATTAACTATGTGGTATGTAAAT	PILER-CR
GTTTTATATTAACTATGTGGTATGTAAAT	CRISPRCasFinder
GTTTTATATTAACTATGTGGTATGTAAAT	CRT

3 spacers

The CRISPR arrays of CP019857_2

>merge|CP019857|2|1290628-1290855|PILER-CR,CRISPRCasFinder,CRT
GTTTTATATTAACTATGTGGTATGTAAATACCTTAAAATCGTCAGATATATAACCTTTTTCTTTATGTTTTATATTAACTATGTGGTATGTAAATTTTATATTAATAAAATCATTTACATTTAAACTCAACAGTTTTATATTAACTATATGGTATGTAAATGACCAAGATACTTGAAAAAATATCGCTGACTATTTTGAGTTTTATATTAACTATGTGGACAAGAATA

>CP019857|2|1|1290628-1290788|PILER-CR
GTTTTATATTAACTATGTGGTATGTAAAT	ACCTTAAAATCGTCAGATATATAACCTTTTTCTTTAT
GTTTTATATTAACTATGTGGTATGTAAAT	TTTATATTAATAAAATCATTTACATTTAAACTCAACA
GTTTTATATTAACTATATGGTATGTAAAT

>CP019857|2|2|1290628-1290855|CRISPRCasFinder
GTTTTATATTAACTATGTGGTATGTAAAT	ACCTTAAAATCGTCAGATATATAACCTTTTTCTTTAT
GTTTTATATTAACTATGTGGTATGTAAAT	TTTATATTAATAAAATCATTTACATTTAAACTCAACA
GTTTTATATTAACTATATGGTATGTAAAT	GACCAAGATACTTGAAAAAATATCGCTGACTATTTTGA
GTTTTATATTAACTATGTGGACAAGAATA

>CP019857|2|1|1290628-1290855|CRT
GTTTTATATTAACTATGTGGTATGTAAAT	ACCTTAAAATCGTCAGATATATAACCTTTTTCTTTAT
GTTTTATATTAACTATGTGGTATGTAAAT	TTTATATTAATAAAATCATTTACATTTAAACTCAACA
GTTTTATATTAACTATATGGTATGTAAAT	GACCAAGATACTTGAAAAAATATCGCTGACTATTTTGA
GTTTTATATTAACTATGTGGACAAGAATA

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86064.1\|1295058_1295301_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86049.1\|1280656_1281736_+\|exported-aminodeoxychorismate-lyase	unknown	unknown	gnl\|CDD\|376862
CP019857.1\|AXU86054.1\|1287597_1288419_-\|lipoprotein	unknown	unknown	gnl\|CDD\|276809
CP019857.1\|AXU86055.1\|1288609_1290037_+\|cell-surface-protein	unknown	unknown	gnl\|CDD\|380277
CP019857.1\|AXU86061.1\|1293493_1294309_+\|phage-anti-repressor	unknown	unknown	gnl\|CDD\|378443
CP019857.1\|AXU86050.1\|1281907_1282582_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
CP019857.1\|AXU86052.1\|1283887_1285552_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223839
CP019857.1\|AXU86057.1\|1291871_1292048_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86060.1\|1293057_1293384_+\|prophage-antirepressor	unknown	unknown	gnl\|CDD\|226144
CP019857.1\|AXU86053.1\|1285955_1287473_-\|site-specific-recombinase	unknown	unknown	gnl\|CDD\|238206
CP019857.1\|AXU86063.1\|1294694_1294856_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86051.1\|1282568_1283816_+\|protease	unknown	unknown	gnl\|CDD\|223896
CP019857.1\|AXU86059.1\|1292531_1292756_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376971
CP019857.1\|AXU86048.1\|1279128_1280454_+\|pyrimidine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|274244
CP019857.1\|AXU86062.1\|1294361_1294580_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86065.1\|1295431_1295749_+\|putative-replication-initiation-and-membrane-attachment	unknown	unknown	unknown
CP019857.1\|AXU86056.1\|1290896_1291115_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|197775
CP019857.1\|AXU86046.1\|1276893_1278066_+\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
CP019857.1\|AXU86047.1\|1278112_1278925_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350160
CP019857.1\|AXU86058.1\|1292053_1292374_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|238045

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86049.1\|1280656_1281736_+\|exported-aminodeoxychorismate-lyase	gnl\|CDD\|376862	pfam02618, YceG, YceG-like family. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of YceG was solved by X-ray crystallography.	3.18128e-117
CP019857.1\|AXU86054.1\|1287597_1288419_-\|lipoprotein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.11852e-08
CP019857.1\|AXU86055.1\|1288609_1290037_+\|cell-surface-protein	gnl\|CDD\|380277	NF033435, S-layer_Clost, S-layer protein SlpA. In Clostridiodes difficile, the S-layer protein precursor, SlpA, is one member of a large paralogous family of protein that share several cell wall-binding repeats. SlpA is cleaved into a larger and smaller protein. The S-layer protein itself is important to adhesion, and portions of it are highly variable, and then N-terminal and C-terminal are well-conserved.	3.57747e-18
CP019857.1\|AXU86061.1\|1293493_1294309_+\|phage-anti-repressor	gnl\|CDD\|378443	pfam10543, ORF6N, ORF6N domain. This domain was identified by Iyer and colleagues.	4.02e-24
CP019857.1\|AXU86050.1\|1281907_1282582_+\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	2.98869e-60
CP019857.1\|AXU86052.1\|1283887_1285552_+\|penicillin-binding-protein	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	5.28831e-97
CP019857.1\|AXU86060.1\|1293057_1293384_+\|prophage-antirepressor	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	9.47499e-34
CP019857.1\|AXU86053.1\|1285955_1287473_-\|site-specific-recombinase	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	1.86731e-29
CP019857.1\|AXU86051.1\|1282568_1283816_+\|protease	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	4.69627e-145
CP019857.1\|AXU86059.1\|1292531_1292756_+\|hypothetical-protein	gnl\|CDD\|376971	pfam02954, HTH_8, Bacterial regulatory protein, Fis family.	0.00775968
CP019857.1\|AXU86048.1\|1279128_1280454_+\|pyrimidine-nucleoside-phosphorylase	gnl\|CDD\|274244	TIGR02644, Thymidine_phosphorylase, pyrimidine-nucleoside phosphorylase. In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff. [Purines, pyrimidines, nucleosides, and nucleotides, Other].	0
CP019857.1\|AXU86056.1\|1290896_1291115_-\|DNA-binding-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.02404e-11
CP019857.1\|AXU86046.1\|1276893_1278066_+\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
CP019857.1\|AXU86047.1\|1278112_1278925_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|350160	cd09009, PNP-EcPNPII_like, purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA). Human PNP catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. Patients with PNP deficiency typically present with severe immunodeficiency, neurological dysfunction, and autoimmunity. Escherichia coli PNPII, product of the xapA/pndA gene, catalyzes the phosphorolysis of xanthosine, inosine and guanosine with equal efficiency and has been referred to as xanthosine phosphorylase and inosine-guanosine phosphorylase. E. coli PNPII is also capable of converting nicotinamide to nicotinamide riboside, and may be involved in the NAD+ salvage pathway. It is one of two purine nucleoside phosphorylases found in E. coli, which also contains PNPI, which displays a different substrate specificity and belongs to a different subgroup of the nucleoside phosphorylase-I (NP-I) family than PNPII. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	9.46657e-176
CP019857.1\|AXU86058.1\|1292053_1292374_-\|DNA-binding-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.84305e-11

>CP019857.1|AXU86055.1|1288609_1290037_+|cell-surface-protein
MKIKKLLIIGLSLSIFIASCPISANALDKIESIKGADKYETAGIIADKQNYTTAILINADSTMADGLSASGLAGAINAPILLTKKNNIPNATLKRLEKAKKVYIIGGENSIDKYTETVLKGKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAFKGEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTRLGGTDRYDTNKKIINKFYSGVKEFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSVLKSTIKLTAIGNLSDSILQQCLNVTKNIGDSNTGREYTVEDAANAVKKLLGVKKFYYEPNYSEDEDLIFLLDKNFDFSGKEYYVFAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGNMKVCNPDDYKNKGSITEEQAKQIALKECAKRHKVSINNLVVDMIDFRDDIYSGNVYAVKINSKNSNGTFGWFFIDIETGKVYN
>CP019857.1|AXU86054.1|1287597_1288419_-|lipoprotein
MIISKKITAILVSFLIMISMVGCAPKESATEVAKKYLDSIEIKDYEVAYNLLSKDSKESVSLEKFEEYQDTLFKLQTLKDYKLGEENKVEKYKYSNKEYTNLVKIKETDTIKYITENKEDTANFDRYFIIEDNEYKLLWHKDFKRALSSNYVKIARSETEKDEDKDYNKAAIDIKKAIEIDDKNPLAYYTQSYIYIELQRYDEALKSIDKYLEYLDKNNEAYKIDASDAYNLRGVIFMSKSEFNKARESYNKALELNPDNEYAKTNLNDIKGL
>CP019857.1|AXU86053.1|1285955_1287473_-|site-specific-recombinase
MSVAIYLRKSRADEEAEKQGEFETLSRHKSTLLKLAKEQNLDVIEIKEELVSGESIIHRPKMLELLKEVEENKYDAVLVMDLDRLGRGDMKDQGIILETFKESKTKIITPRKTYDLTDEFDEEYSEFEAFMARKELKLISRRMQRGRIKSVEEGNFIGTSAPFGYDAVTTGRKERILVPNKDADVVRTIFDLYINEDMGCSKISKYLNNLGIKTATGANWYNSAITNIIKNKVYCGYIQWQKKDYKKSKNPNKIKTVKLRPKDEWIEAKGKHEPLISEITWKKAQNILKKNGHVSYGNQIKNPLAGIVICKNCGRPLVYRPYADHDYIICYHPGCNKSSRFEFIEAAILKSLEDTVKKYQLKASDIDLDKNNKDSNIEFQKRVLKGLETELKELGKQKNKLYDLLERGIYDEDTFIERSNNISSRTEEIKDSIKTVKNRLNTVKKDNSKIIEDIKTVLSLYHDSDSLGKNKLLKSVIDKAVYYKSKEQKLDSFELMVHLKLHEDQ
>CP019857.1|AXU86052.1|1283887_1285552_+|penicillin-binding-protein
MSKKKTPFLKKVGKRSWCIFTIILIIYSVLIYRLVDIQVLKGDKYKQSVESQSVEKVELNSGRGIIYDRNNKKLTDTSKSQILIVEKEKLNNNYKILELIKKATKMNDLDIYKAVQEQLTRPIIQIQTKNIDKSMKKELEKNGIMVEEKTMRYAKDGLLSHTIGYIKEDDKSGQSGIEKSMDSVLRNSNEKYISAFKAGDAGNEKSLNILKGSVKTVDNKDKDRHLKTTIDYNIQKKLEQILNKEENPTAAIISEASTGEILAMCSRPNFDQNDISKSLKGKNGEFENRVIKATYPPGSVFKMVVLFSALENGVIDENYTYNCTGKTKVGNTNEILRCNKRDGHGFQNLRQAFSNSCNPAFLDIAMKLGKEKILKSAEKLHLFEKVDIGLDEEKIREAPKNISIRNLAIGQENIEFTPLQINQMTQIIANNGTFKPLYLYKSLVDNNMNTIKTYKSSKKEELISPYVCTQVKEYMKSVSRTGTAKDLKDIEGGCGVKTGTAQSSLNKKAIDHGWITGFYPEERPKYVITVLVEGTQKGNKSATPIFKEICESIK
>CP019857.1|AXU86051.1|1282568_1283816_+|protease
MELNKVELLAPAGDLERLKIAITYGADAVYIGGEIFGMRSAAKNFSKEDMAEGVAFAHERGKKVFVTVNIIPHNEDFLQLEDYLLELEEIGIDAVIIADPGVLSVIKKVIPNMEIHLSTQANTTNYLSANFWYEHGIKRVVVARELSFDEISEIRAKTPLDMDIEAFMHGAMCISYSGRCLISNYMTGRDANKGSCAQSCRWQYHLVEEKRPGEYFPIYEDERGTFFFNSKDLCMIEYIPELIKSGITSLKIEGRMKTAYYVATVVRAYRMAIDEFYRDPENWKFNPMWMEELKKGSHRHFTSGFYLNKPTTEDQNYQSASYVRNYDFIGIVRETEDEDGLIVVEQRNKMCVGDEIEVMGPYKETMFTKIEEMYNEEGEAIESAPHPRQIVKLKLSVKVGKDYMLRKVIEEKVEE
>CP019857.1|AXU86050.1|1281907_1282582_+|O-methyltransferase
MSNIVNDLVEDYIRVTLKEKEGFLKDLEIYAEENSVPIIHKEVSDLLKVLLKVQKPKRILEVGCAIGYSSIFFATIIGKDADIITVERNEKMIEKAKENIKLAGFDNNITILEGDAEEKLSQVQGEFDLIFIDAAKGQYKLFFDLVIDKLKDGGLLVSDNILYKGMVAHDDFVVRRKKTIVKRMRNYLDYICNCDYLSTSLVPIGDGVALSYKESKRGDVDGIK
>CP019857.1|AXU86049.1|1280656_1281736_+|exported-aminodeoxychorismate-lyase
MNFKENRLKIAVLIIVILIILAGIFVFIQIGPYDKNNKKDVIIDVPSGASVGKISDILYENKLIKNELLFKLLVKVSNKAPSIKSGTYLLNQSYSNNDIISLLVSGKIYQDGIKVTIPEGATSKEIIAMLVSKNLGDKATFENLIKKPQEFYDKFPYLKEDGITSLEGFLYPETYYFNSKKQSEEDILSEMLKVFDSKYTDKFKKKQKELNMTLQEVMEMASIIEKEAVLDKDRPIIASVFYNRLKVGMPLQSDATIQYIFEERKKIVTYDDLKIDSPYNSYKNKGLPPTPISNPGIKSIEAALYPEKTDYLYFVAKIDGGNNYSTNYQDHLKYVKEYKEARDKQSKDTKATNKENTKK
>CP019857.1|AXU86048.1|1279128_1280454_+|pyrimidine-nucleoside-phosphorylase
MRMYDIIKKKRDNLELSKKEINYFIENYSKGDIPDYQASALLMSIYLNKMNKQETVHLTEAMMNSGDMINLSEIDGIKVDKHSTGGVGDKTTIALIPLVASCGAPVAKMSGRGLGHTGGTIDKLESIPGFSTEMEISKFIDSVNKSKIAVCGQSAKVAIADKKIYALRDVTATVDNISLISSSVMSKKLASGADAIVLDVKTGDGAFMKTLEESFELAKSMVDIGTGMNRDTIGIVTDMDEPLGFAVGNSLEVIEAIETLKGNGPKDLVELCEVLGAYMLVLSKVAHDFEDGVEKIRESIKSGTAIQKLKEFIENQGGNKDVVDDYSLFKKSKYKYPVKSTKSGYISKIKAEDVGVSAMILGAGRETKDDILDLSAGIILEKKVGDYVNEGEVLAYMYYNDEQKLSLAKGRFIDSYSIVDSKIEKNKLIYGIVTKEEIKKF
>CP019857.1|AXU86047.1|1278112_1278925_+|purine-nucleoside-phosphorylase
MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIKYSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRFHYYEGYSQKEATFPVRVMKELGVEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSSKYVDVVKNCAKECNIDVKEGVYMFFSGPNYETPAEVRMAQILGADAVGMSTVPEVIVASHSNIGVIGISCITNMAAGILNQPLSHEEVIETTQKVKSEFMNLVKTTVKNL
>CP019857.1|AXU86046.1|1276893_1278066_+|phosphopentomutase
MSRVIWIVIDSVGIGALPDAEKFGDSKDVSTLGNIFKEYPDIQIPNMRNLGIGNIDGIDFFESIKEPIGCFGKCKEMSQGKDTTTGHWEMTGIIVDKPFKTFEHGFSKEIIEEFEKKTGRKVVGNKPASGTVIIDEYGEHQIKTGDVIVYTSADSVFQIAANEEVIPLEELYNMCKIAREIMMGDNAVARVIARPFIGKKKGEFVRTSNRRDYSLDPFEPTVLDNIKESGLDVLAVGKIEDIFNGKGITDAIHTKSNMDGVDETLNYMKQDNKGLIYSNLVDFDSKYGHRRDPEGYKKALEEFDSRLPEIMANMREDDILIINADHGNDPTYKGTDHTREYIPVMIYGNKIKKGFNLGVKDTFADIGATVADILNVKLPKHGSSFKEDLF
>CP019857.1|AXU86056.1|1290896_1291115_-|DNA-binding-protein
MLKKLRKERGMTQNELAEKANYSRAYISDLENKRYKNINISTIIDLSLALEIDFLELCRYYCEEELRKRKLM
>CP019857.1|AXU86057.1|1291871_1292048_+|hypothetical-protein
MDEMGKNKIITINLEDEIKSLDLDIFIKYIEIFKKKDNDSFLKTLDYMKYSIKKNKAL
>CP019857.1|AXU86058.1|1292053_1292374_-|DNA-binding-protein
MGLEKINELRKERGLTSEQLSKLSGVPKGTLDKILTGVTKDPKLETLKSIARVLDCTLDDFDDKPNLNKLDDINNKEIKEFAQLFLEVDDETKEYVIGLMKKTLKK
>CP019857.1|AXU86059.1|1292531_1292756_+|hypothetical-protein
MRELYRELLGEMARNDLNRKKLASKLGVSPKTLSNKLKGNTEFTWKEVKQIRDIVAPNKTLEELFRHEKESVNN
>CP019857.1|AXU86060.1|1293057_1293384_+|prophage-antirepressor
MSNNLQIFKNNDFGEIRTVEIDGKLYFVATDIARCLGYKDTTNAIKQHCKWVVKHHIPHPQSKTKTLEVNVIPAGDMYRLITNSELPSAEKFERWVFDEVLPSIRKTG
>CP019857.1|AXU86061.1|1293493_1294309_+|phage-anti-repressor
MNNLQVIERNNKRVLTTQQLADVYETDVRNISNNFNNNKDRFIEGKHYFLLQGDDLKNFKGIHTEYENLKFTSKMYLWTERGANRHCKILDTDKAWEQFDNLEESYFNKKKDTLITNQLSPELQMFKQIFDTVAKQEIEQKQIKQEITETKQEIQSIKDVVTLNTTDWREETRRLLVSMSQNLGGNEYINTLRKESYEFLCKRFNVDLKRRLNNRRRKMAEEGVCKSRREKFNYLDVIQEQNYLIEGYVIVIKDMALKYGISSDLSKNCNN
>CP019857.1|AXU86062.1|1294361_1294580_+|hypothetical-protein
MKILQQFKPYKYDEEKNIEYDEKIIANQNTEVYIVYPRISDEENRRRWKEFDEVAKEVAINIAMKKAETVES
>CP019857.1|AXU86063.1|1294694_1294856_+|hypothetical-protein
MLSLDISKKNVMTLKKDGKFLADIVFKDIKTGKKISVGTLNKKSAGQSNQHNK
>CP019857.1|AXU86064.1|1295058_1295301_+|hypothetical-protein
METARLIAIGQIKQAEKEISRLQGTKNNSSLMWWEAVKFASQNILEGLEHDIELEASTEFREFMIIQEELERDRPIDVQL
>CP019857.1|AXU86065.1|1295431_1295749_+|putative-replication-initiation-and-membrane-attachment
MNVVKGCNKQLHVTLNSTCLQDNNLSWQAKGLHLYLMTKAENETIYLEDLKNKSSNGRDSTANILNELIEKGYVSREIRRDALTGKVLGGYEYKIYEESLKNIEK

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Crispr_ID: CP019857_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_3

1314698-1315056

Orphan

I-A

Consensus_repeat	Method
GTTTTAGATTAACTATATGGAATGTAAAT	PILER-CR
GTTTTAGATTAACTATATGGAATGTAAAT	CRISPRCasFinder
GTTTTAGATTAACTATATGGAATGTAAAT	CRT

5 spacers

The CRISPR arrays of CP019857_3

>merge|CP019857|3|1314698-1315056|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGATTAACTATATGGAATGTAAATAATTTTTCGAGAGTCTCAATTTACAGAAGAAATTGGAGTTTTAGATTAACTATATGGAATGTAAATCAAATTGTCTAATCCTAATTTTTTCTTTGCATCTTCTGTTTTAGATTAACTATATGGAATGTAAATTGTAATTAAGTTAGATATGGCAAAAGAAATAGCTATGAGTTTTAGATTAACTATATGGAATGTAAATTTTAATGATTCTACAACTCTTACAGACTCAGATGATGTTTTAGATTAACTATATGGAATGTAAATGGGTGGGAGATATGGCAACTATCCACACATGAAATTGGTTTTAGATTAACTATGTGGATTCAAAAT

>CP019857|3|2|1314698-1314990|PILER-CR
GTTTTAGATTAACTATATGGAATGTAAAT	AATTTTTCGAGAGTCTCAATTTACAGAAGAAATTGGA
GTTTTAGATTAACTATATGGAATGTAAAT	CAAATTGTCTAATCCTAATTTTTTCTTTGCATCTTCT
GTTTTAGATTAACTATATGGAATGTAAAT	TGTAATTAAGTTAGATATGGCAAAAGAAATAGCTATGA
GTTTTAGATTAACTATATGGAATGTAAAT	TTTAATGATTCTACAACTCTTACAGACTCAGATGAT
GTTTTAGATTAACTATATGGAATGTAAAT

>CP019857|3|3|1314698-1315056|CRISPRCasFinder
GTTTTAGATTAACTATATGGAATGTAAAT	AATTTTTCGAGAGTCTCAATTTACAGAAGAAATTGGA
GTTTTAGATTAACTATATGGAATGTAAAT	CAAATTGTCTAATCCTAATTTTTTCTTTGCATCTTCT
GTTTTAGATTAACTATATGGAATGTAAAT	TGTAATTAAGTTAGATATGGCAAAAGAAATAGCTATGA
GTTTTAGATTAACTATATGGAATGTAAAT	TTTAATGATTCTACAACTCTTACAGACTCAGATGAT
GTTTTAGATTAACTATATGGAATGTAAAT	GGGTGGGAGATATGGCAACTATCCACACATGAAATTG
GTTTTAGATTAACTATGTGGATTCAAAAT

>CP019857|3|2|1314698-1315056|CRT
GTTTTAGATTAACTATATGGAATGTAAAT	AATTTTTCGAGAGTCTCAATTTACAGAAGAAATTGGA
GTTTTAGATTAACTATATGGAATGTAAAT	CAAATTGTCTAATCCTAATTTTTTCTTTGCATCTTCT
GTTTTAGATTAACTATATGGAATGTAAAT	TGTAATTAAGTTAGATATGGCAAAAGAAATAGCTATGA
GTTTTAGATTAACTATATGGAATGTAAAT	TTTAATGATTCTACAACTCTTACAGACTCAGATGAT
GTTTTAGATTAACTATATGGAATGTAAAT	GGGTGGGAGATATGGCAACTATCCACACATGAAATTG
GTTTTAGATTAACTATGTGGATTCAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86095.1\|1315297_1315663_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378481
CP019857.1\|AXU86091.1\|1313471_1313912_+\|phage-protein	unknown	unknown	gnl\|CDD\|378084
CP019857.1\|AXU86100.1\|1319134_1319956_+\|prophage-antirepressor-related-protein	unknown	unknown	gnl\|CDD\|226144
CP019857.1\|AXU86097.1\|1316459_1317326_+\|prophage-antirepressor-related-protein	unknown	unknown	gnl\|CDD\|214989
CP019857.1\|AXU86092.1\|1313986_1314106_+\|phage-protein	unknown	unknown	unknown
CP019857.1\|AXU86098.1\|1317380_1317536_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86088.1\|1311417_1311603_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86096.1\|1316096_1316339_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86089.1\|1311603_1312914_+\|phage-protein	unknown	unknown	gnl\|CDD\|377435
CP019857.1\|AXU86090.1\|1312930_1313401_+\|phage-protein	unknown	unknown	gnl\|CDD\|378178
CP019857.1\|AXU86087.1\|1310996_1311434_+\|phage-protein	unknown	unknown	unknown
CP019857.1\|AXU86084.1\|1309094_1309442_+\|phage-protein	unknown	unknown	unknown
CP019857.1\|AXU86094.1\|1315125_1315323_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86085.1\|1309441_1309732_+\|phage-protein	unknown	unknown	gnl\|CDD\|377415
CP019857.1\|AXU86093.1\|1314254_1314416_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86101.1\|1320018_1320195_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86086.1\|1309841_1310648_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86099.1\|1318126_1318651_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86103.1\|1321400_1323689_+\|phage-tail-tape-measure-protein	unknown	unknown	gnl\|CDD\|131723
CP019857.1\|AXU86102.1\|1320560_1321334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373083

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86097.1\|1316459_1317326_+\|prophage-antirepressor-related-protein	gnl\|CDD\|214989	smart01040, Bro-N, BRO family, N-terminal domain. This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.	2.99127e-10
CP019857.1\|AXU86091.1\|1313471_1313912_+\|phage-protein	gnl\|CDD\|378084	pfam08890, Phage_TAC_5, Phage XkdN-like tail assembly chaperone protein, TAC. This is a family of phage tail assembly chaperone proteins, TACs, from Gram-positive bacteriophages, in particular PBSX from Firmicutes.	3.10409e-55
CP019857.1\|AXU86085.1\|1309441_1309732_+\|phage-protein	gnl\|CDD\|377415	pfam04883, HK97-gp10_like, Bacteriophage HK97-gp10, putative tail-component. This family of proteins is found in the caudovirales. It may be a tail component.	4.09969e-14
CP019857.1\|AXU86095.1\|1315297_1315663_-\|hypothetical-protein	gnl\|CDD\|378481	pfam10711, DUF2513, Hypothetical protein (DUF2513). This family is found in bacteria. The function is not known.	1.6383e-27
CP019857.1\|AXU86089.1\|1311603_1312914_+\|phage-protein	gnl\|CDD\|377435	pfam04984, Phage_sheath_1, Phage tail sheath protein subtilisin-like domain. This entry represents the second domain in a variety of phage tail sheath proteins. According to ECOD this domain has a subtilisin-like structure.	2.17301e-36
CP019857.1\|AXU86090.1\|1312930_1313401_+\|phage-protein	gnl\|CDD\|378178	pfam09393, DUF2001, Phage tail tube protein. This is a family of phage tail tube proteins including protein XkdM from phage-like element PBSX protein whose structure adopts a beta barrel flanked with alpha helical regions.	1.45311e-56
CP019857.1\|AXU86103.1\|1321400_1323689_+\|phage-tail-tape-measure-protein	gnl\|CDD\|131723	TIGR02675, Mu-like_prophage_FluMu_protein_gp42, tape measure domain. Proteins containing this domain are strictly bacterial, including bacteriophage and prophage regions of bacterial genomes. Most members are 800 to 1800 amino acids long, making them among the longest predicted proteins of their respective phage genomes, where they are encoded in tail protein regions. This roughly 80-residue domain described here usually begins between residue 100 and 250. Many members are known or predicted to act as phage tail tape measure proteins, a minor tail component that regulates tail length.	2.06458e-14
CP019857.1\|AXU86100.1\|1319134_1319956_+\|prophage-antirepressor-related-protein	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	1.12192e-18
CP019857.1\|AXU86102.1\|1320560_1321334_+\|hypothetical-protein	gnl\|CDD\|373083	pfam14471, DUF4428, Domain of unknown function (DUF4428). This putative zinc finger domain is found in uncharacterized bacterial proteins.	0.000598973

>CP019857.1|AXU86093.1|1314254_1314416_+|hypothetical-protein
MDNFLIGVLASLTASLIGYIVCLCIKKVKSHSVQESDLDVELKFSFKFKKNKH
>CP019857.1|AXU86092.1|1313986_1314106_+|phage-protein
MGLEINERALAAASILIKIEDEEEAMKEAERERKRGRRR
>CP019857.1|AXU86091.1|1313471_1313912_+|phage-protein
MSNLSAFLSQNAIKVDNVKYIASDRFLDEEGKPVEWELKVLSSEEDEVLRRNCTKRVKVIGNNGKPTGQFTSEIDYNSYVAELCVASTVFPDLKDAELQNSYGVMGEAQLLKTMLTAGEYVNYTVKVNEVNGFDTTFEDKVEEAKN
>CP019857.1|AXU86090.1|1312930_1313401_+|phage-protein
MFQQIKARDTISASKAECYVTIEGKRYNFMQAINLEAKMEKNKSEVPILGSTTKGNKSTGSKYTGSATFHYNTSIFRELLYRYKETGEDIYFDIQVTNEDPTSSAGRQTIILKDCNMDSGIIVKFDADGEYLDEDMDFTCEDWELVEKFNIINGME
>CP019857.1|AXU86089.1|1311603_1312914_+|phage-protein
MALGGGTFVTQNKVLPGAYINFVSATRATSSLSDRGIVAMPLELDWGIDEEIFTVTSDDFEKYSTKYFGYDYTHEKLKGLRDLFKNIRLGYFYKLNKGVKASCSIATAKYSGTRGNDLKVIVTTNIDDNTKFDVVTLLDNKKVDTQIAKVITDLQDNDYITWKKDTTLEASAGLVFTGGTNGESVTGAEYQAFLDKIESYSFNALGSLATTAEIKSLFVEFTKRMRDKVGAKFQTVLYKKNDADYEGVVSVENKVKDTGLLESSLVYWTTGAIAGCDINKSNTNKKYDGEFDVDVNYTQIQLEEALKSGKFIFHKVGDEVHVLEDINTFVSFTDDKNDDFSSNQSVRVLDQIANDIATLFNEKYLGKVPNDKAGRISFWNDVVKHHKELENIRAIEDFKTDDVSVELGNDKKTVIVSDAVKVINAMSKLYMTVSVS
>CP019857.1|AXU86088.1|1311417_1311603_+|hypothetical-protein
MIILNKTLSKEDDYKFTKEQIVNSKKYVNRKDLLNAILKENELYSFSEVEEIINNFMKGVS
>CP019857.1|AXU86087.1|1310996_1311434_+|phage-protein
MLNNIIDGISIKLDKTFGESYTIYSEDVEQGINEPCFFICPLNPSKTSYPNGRTLKKNSFDVHYFPRSKDKSFEINEVAEMLLEELEYIEIDGDLVRGTNMNFEIIDNVLHFFVDYNYFTIKSNDTEKMNDVELFGGLKRGDNFE
>CP019857.1|AXU86086.1|1309841_1310648_+|hypothetical-protein
MAKFLDITGKKFGRLRVIKFSKEIKSGKRNRKYWLCKCDCGNFKEIRTDSLTSGLVQSCGCLKKEQDKLNLTDKYQFKKKYKVQNKRLYSIWKGIISRCTDKNNKRYNRYGERNIIVCDEWFCYDNFANWALSNGYSEKLTIDRINNEGNYESSNCRWVDIKTQCRNRSTNILVKHEEKEITLIELSEKTGISYSCLRSRYSKGLVGNKLIEKVKIIEESRAKLSIEDVKEIRKKYSDGYTIKQLSEIYPVTYSSISNIVHRRTWKNI
>CP019857.1|AXU86085.1|1309441_1309732_+|phage-protein
MARWGSVDFREFKRVCKKMEKLTKIDLDKFCKDAARELAARLLGKVIRRTPVDTGFLRQGWNGVAYARSLPVYKQGNNYIIEVVNPTEYALTQWGI
>CP019857.1|AXU86084.1|1309094_1309442_+|phage-protein
MVSKTRKAIEMLYRDKCTIVEYQPIKDPVTKRTNNKEVIVLENQPCKLSYKNIVSATEGKLAKLEQTIKLFISPDIEIKAGSKLIINDKEYVRSGESAIYPNHQEIILELFKDKA
>CP019857.1|AXU86094.1|1315125_1315323_+|hypothetical-protein
MNKDIEFIACSMRLKILIQAREDLIENINKYSTKSYEKNIDNYKKLDMIFEDAIKFEAILLSSLK
>CP019857.1|AXU86095.1|1315297_1315663_-|hypothetical-protein
MKRDLELIRDILIKMEESDADRMSISDFMTDVYDERTISYHLQLLLDVGFIEATPMGVQRCLYKHYIVKRITSFGYDYLDNIRDDTVWNKTKKQLGNFASSASLKVIGSVASSVILKMIGV
>CP019857.1|AXU86096.1|1316096_1316339_+|hypothetical-protein
MTVTRYNVIINVTSYRKEVNKIATKSRAEYMKNRRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDEELEQKE
>CP019857.1|AXU86097.1|1316459_1317326_+|prophage-antirepressor-related-protein
MKNLIVKEFNGSQIYTFMWKEKSCWIANQIVGLFDYADVSKTIQDCIKAEDFEIEQEYDVLKGNEFNDFVTTLNVVANNIISNKARSITIFYEDGLYGFLQYTDKPIGVQFRKWLRREVLPAIRQHGAYITNNADPQALREKANEIESLDTVNKTIEILTPFLDNAGIDEKAKLLTAKTIYKKAGIELPLEIEEKEHFFDTVQIATKLNVYSKSNKPAFHAIGEIIKKLDIQDNEKLVVLESKRGWSGSVNKYSQSVIDKIRHWIEENNRPTKIQGEKKNFHVVYKIE
>CP019857.1|AXU86098.1|1317380_1317536_+|hypothetical-protein
MCENLLDMDRIELIRELGSIFEKMRNENPDKFYRFVSLVKEECRKKEEKNK
>CP019857.1|AXU86099.1|1318126_1318651_+|hypothetical-protein
MWGKFKKLSLLKKILVIFLIYFVVFTVSMMIHQAIRDSKNRDEVNEGNITKENIISEREKEDIYKQEMQAKVDSMIPEDLKDKTTYYVNILNPTKGEGYIVSIQVENSRFNDENECRNFTKEFVNNIKDMNDIHSVRISFIVDVTLTYNVFLDDWNNIKNNVNLIDDLDFSSGN
>CP019857.1|AXU86100.1|1319134_1319956_+|prophage-antirepressor-related-protein
MKNELMMFEEKKVEVLEYNGQVLFNPYDCGRCLELSDSAIRNHLSKMNDTQAVLLKNSNVLDKDFRKLHNTGEKFLTESGVYKLIFKSKKEEAERFQDWISDEVLPAIRQTGAYITNNADPDKLREKASEIEKLQLAYNSTSMLKELLDGAGFDNKSKLLTAKTLYKKAGIDLPIEINEEEHYFDTKQIASKLKIYSKSNKPAQMAVCEIIKKIDLEENEVKGVWETNGSWTGTVNKYTKSVIDKVRNWIEENNRPAKIAGEKKNYHVVYKIE
>CP019857.1|AXU86101.1|1320018_1320195_+|hypothetical-protein
MCENLLNEYNLKTDEDVEYFVKFATLLYKLKQDNEEKFQEYAEILRGILREQQERENK
>CP019857.1|AXU86102.1|1320560_1321334_+|hypothetical-protein
MGLFSGNESCCICGEKGKQKISDGVICSECLKKYKDTFSIVEPTDVIKKISSEEIKKSIRLTLENKKRFESFNASKKVGIYLLVDENKKQLIISDKISNLNKNKRVYDFRDIISFELLEDDESIIKSGLGGAIGGGLLFGETGAIAGSILGKKKIKTYVNSLKIKITINNIKNSTKYIYLINSKISTNSSLYKESYNYAQEILSTLSIITSSKSIEDKKESISSSTADEILKYKNLLNMEAITQEEFDAKKKELLNL
>CP019857.1|AXU86103.1|1321400_1323689_+|phage-tail-tape-measure-protein
MATIQTSIRIFDGMTPAFRHMTNAMNIVLSSFEQLQRTSSNAIDANSIRTAREELARAEAGFDRLEQQIREADEQQKRFNDDVRKGASSTDKLVENAKRLVATYIGLRSVGGLINLSDQMTSTNARLAMINDGQQSDGGLNKMIFQSAERARASYLDTAKIVSRVGMNAGKAFSSTKEIVAFAEQLNKKFVIAGATTEETNSVLLQLTQGLGSGVLRGEELNAVFESAPNIIQSIADYLEVDIGKIRGMASEGMLTADIVKNSLLSAAEQTNAEFEKMPYTFGQIWTSIKNNAVMIFGVIQKKIEQSMSSRGFRTFIDNFISGLYVLGNVFFNIFNGIISILGSPAFQSFSNTMIVGISLISQALGWIVTQALNLANIFAQNWSIIGPIIAGVVGILGTYLIALGSIWLWETLCKISKNALAIASAIHALAIHAELTETQMATVAQWGLNAAILACPIFWIVAGIIALVAVLFVGVAIFNHFAGTSVSAIGIVAGAISVAAAFVGNLFIATGNLIIDIVALIYNSLANFAEFFANFLDDPIGSVIRAVSRMADAVLGILRSIASAIDTIFGSNLANAVSGWQDKLQGWTDKVAGEAKIKVELMDPNKLHFDRFNCGKAWDAGYKWGDKLETNIKDKFDISKIAEKAKKDLGLDDLWDDKYGLGDGFGSAGLNSPLNDAAKGAKDTAGNTAKMAKTMDKSQEDLKYLRDIAEQETINRFTGVNIKIDMNNTNNISKDTDVDGIVNVLTEKLNDAMIVSAEGIV

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Crispr_ID: CP019857_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_4

1317634-1317993

Orphan

I-A

Consensus_repeat	Method
GTTTTAGATTAACTATATGGAATGTAAAT	CRISPRCasFinder
GTTTTAGATTAACTATATGGAATGTAAAT	PILER-CR

5 spacers

The CRISPR arrays of CP019857_4

>merge|CP019857|4|1317634-1317993|CRISPRCasFinder,PILER-CR
GTTTTATATTAACTAAGTGGTATGTAAATCGTACAGATAGTATTGCATTAGAGGAAAGTTTAAAAGCGTTTTAGATTAACTATATGGAATGTAAATGTTTTTAAAGCTTCTTCAAGTTGTATTTGTGTATAATGTTTTAGATTAACTATATGGAATGTAAATCCAACTGAATAAACAATAATTTTATCAATTTCTTTAGTTTTAGATTAACTATATGGAATGTAAATTATTTTACAGATGAACAATTACAATTACTTCTTGAATGTTTTATATTAACTAAGTGGTATGTAAATAAAGCAAAAGATAGGAATGATAATTTTAAAACTCCAAACTTTTATATTAACAATGTGGAGAAAAACT

>CP019857|4|4|1317634-1317993|CRISPRCasFinder
GTTTTATATTAACTAAGTGGTATGTAAAT	CGTACAGATAGTATTGCATTAGAGGAAAGTTTAAAAGC
GTTTTAGATTAACTATATGGAATGTAAAT	GTTTTTAAAGCTTCTTCAAGTTGTATTTGTGTATAAT
GTTTTAGATTAACTATATGGAATGTAAAT	CCAACTGAATAAACAATAATTTTATCAATTTCTTTA
GTTTTAGATTAACTATATGGAATGTAAAT	TATTTTACAGATGAACAATTACAATTACTTCTTGAAT
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAGCAAAAGATAGGAATGATAATTTTAAAACTCCAAA
CTTTTATATTAACAATGTGGAGAAAAACT

>CP019857|4|3|1317701-1317860|PILER-CR
GTTTTAGATTAACTATATGGAATGTAAAT	GTTTTTAAAGCTTCTTCAAGTTGTATTTGTGTATAAT
GTTTTAGATTAACTATATGGAATGTAAAT	CCAACTGAATAAACAATAATTTTATCAATTTCTTTA
GTTTTAGATTAACTATATGGAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86091.1\|1313471_1313912_+\|phage-protein	unknown	unknown	gnl\|CDD\|378084
CP019857.1\|AXU86094.1\|1315125_1315323_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86097.1\|1316459_1317326_+\|prophage-antirepressor-related-protein	unknown	unknown	gnl\|CDD\|214989
CP019857.1\|AXU86092.1\|1313986_1314106_+\|phage-protein	unknown	unknown	unknown
CP019857.1\|AXU86093.1\|1314254_1314416_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86107.1\|1326557_1326977_+\|phage-protein	unknown	unknown	gnl\|CDD\|378510
CP019857.1\|AXU86096.1\|1316096_1316339_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86089.1\|1311603_1312914_+\|phage-protein	unknown	unknown	gnl\|CDD\|377435
CP019857.1\|AXU86090.1\|1312930_1313401_+\|phage-protein	unknown	unknown	gnl\|CDD\|378178
CP019857.1\|AXU86100.1\|1319134_1319956_+\|prophage-antirepressor-related-protein	unknown	unknown	gnl\|CDD\|226144
CP019857.1\|AXU86102.1\|1320560_1321334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373083
CP019857.1\|AXU86098.1\|1317380_1317536_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86108.1\|1326977_1328027_+\|phage-protein	unknown	unknown	gnl\|CDD\|377414
CP019857.1\|AXU86105.1\|1324386_1326279_+\|phage-cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|366353
CP019857.1\|AXU86095.1\|1315297_1315663_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378481
CP019857.1\|AXU86101.1\|1320018_1320195_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86104.1\|1323704_1324394_+\|phage-cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|236880
CP019857.1\|AXU86099.1\|1318126_1318651_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86103.1\|1321400_1323689_+\|phage-tail-tape-measure-protein	unknown	unknown	gnl\|CDD\|131723
CP019857.1\|AXU86106.1\|1326292_1326553_+\|phage-protein	unknown	unknown	gnl\|CDD\|378501

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86091.1\|1313471_1313912_+\|phage-protein	gnl\|CDD\|378084	pfam08890, Phage_TAC_5, Phage XkdN-like tail assembly chaperone protein, TAC. This is a family of phage tail assembly chaperone proteins, TACs, from Gram-positive bacteriophages, in particular PBSX from Firmicutes.	3.10409e-55
CP019857.1\|AXU86100.1\|1319134_1319956_+\|prophage-antirepressor-related-protein	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	1.12192e-18
CP019857.1\|AXU86097.1\|1316459_1317326_+\|prophage-antirepressor-related-protein	gnl\|CDD\|214989	smart01040, Bro-N, BRO family, N-terminal domain. This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.	2.99127e-10
CP019857.1\|AXU86107.1\|1326557_1326977_+\|phage-protein	gnl\|CDD\|378510	pfam10934, DUF2634, Protein of unknown function (DUF2634). Some members in this family of proteins are annotated as phage related, xkdS however currently there is no known function.	2.99558e-36
CP019857.1\|AXU86089.1\|1311603_1312914_+\|phage-protein	gnl\|CDD\|377435	pfam04984, Phage_sheath_1, Phage tail sheath protein subtilisin-like domain. This entry represents the second domain in a variety of phage tail sheath proteins. According to ECOD this domain has a subtilisin-like structure.	2.17301e-36
CP019857.1\|AXU86090.1\|1312930_1313401_+\|phage-protein	gnl\|CDD\|378178	pfam09393, DUF2001, Phage tail tube protein. This is a family of phage tail tube proteins including protein XkdM from phage-like element PBSX protein whose structure adopts a beta barrel flanked with alpha helical regions.	1.45311e-56
CP019857.1\|AXU86102.1\|1320560_1321334_+\|hypothetical-protein	gnl\|CDD\|373083	pfam14471, DUF4428, Domain of unknown function (DUF4428). This putative zinc finger domain is found in uncharacterized bacterial proteins.	0.000598973
CP019857.1\|AXU86108.1\|1326977_1328027_+\|phage-protein	gnl\|CDD\|377414	pfam04865, Baseplate_J, Baseplate J-like protein. The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologs, which are thought to have been horizontally transferred.	8.97207e-52
CP019857.1\|AXU86104.1\|1323704_1324394_+\|phage-cell-wall-hydrolase	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	3.76553e-11
CP019857.1\|AXU86095.1\|1315297_1315663_-\|hypothetical-protein	gnl\|CDD\|378481	pfam10711, DUF2513, Hypothetical protein (DUF2513). This family is found in bacteria. The function is not known.	1.6383e-27
CP019857.1\|AXU86105.1\|1324386_1326279_+\|phage-cell-wall-hydrolase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.93424e-27
CP019857.1\|AXU86103.1\|1321400_1323689_+\|phage-tail-tape-measure-protein	gnl\|CDD\|131723	TIGR02675, Mu-like_prophage_FluMu_protein_gp42, tape measure domain. Proteins containing this domain are strictly bacterial, including bacteriophage and prophage regions of bacterial genomes. Most members are 800 to 1800 amino acids long, making them among the longest predicted proteins of their respective phage genomes, where they are encoded in tail protein regions. This roughly 80-residue domain described here usually begins between residue 100 and 250. Many members are known or predicted to act as phage tail tape measure proteins, a minor tail component that regulates tail length.	2.06458e-14
CP019857.1\|AXU86106.1\|1326292_1326553_+\|phage-protein	gnl\|CDD\|378501	pfam10844, DUF2577, Protein of unknown function (DUF2577). This family of proteins has no known function.	3.68145e-19

>CP019857.1|AXU86098.1|1317380_1317536_+|hypothetical-protein
MCENLLDMDRIELIRELGSIFEKMRNENPDKFYRFVSLVKEECRKKEEKNK
>CP019857.1|AXU86097.1|1316459_1317326_+|prophage-antirepressor-related-protein
MKNLIVKEFNGSQIYTFMWKEKSCWIANQIVGLFDYADVSKTIQDCIKAEDFEIEQEYDVLKGNEFNDFVTTLNVVANNIISNKARSITIFYEDGLYGFLQYTDKPIGVQFRKWLRREVLPAIRQHGAYITNNADPQALREKANEIESLDTVNKTIEILTPFLDNAGIDEKAKLLTAKTIYKKAGIELPLEIEEKEHFFDTVQIATKLNVYSKSNKPAFHAIGEIIKKLDIQDNEKLVVLESKRGWSGSVNKYSQSVIDKIRHWIEENNRPTKIQGEKKNFHVVYKIE
>CP019857.1|AXU86096.1|1316096_1316339_+|hypothetical-protein
MTVTRYNVIINVTSYRKEVNKIATKSRAEYMKNRRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDEELEQKE
>CP019857.1|AXU86095.1|1315297_1315663_-|hypothetical-protein
MKRDLELIRDILIKMEESDADRMSISDFMTDVYDERTISYHLQLLLDVGFIEATPMGVQRCLYKHYIVKRITSFGYDYLDNIRDDTVWNKTKKQLGNFASSASLKVIGSVASSVILKMIGV
>CP019857.1|AXU86094.1|1315125_1315323_+|hypothetical-protein
MNKDIEFIACSMRLKILIQAREDLIENINKYSTKSYEKNIDNYKKLDMIFEDAIKFEAILLSSLK
>CP019857.1|AXU86093.1|1314254_1314416_+|hypothetical-protein
MDNFLIGVLASLTASLIGYIVCLCIKKVKSHSVQESDLDVELKFSFKFKKNKH
>CP019857.1|AXU86092.1|1313986_1314106_+|phage-protein
MGLEINERALAAASILIKIEDEEEAMKEAERERKRGRRR
>CP019857.1|AXU86091.1|1313471_1313912_+|phage-protein
MSNLSAFLSQNAIKVDNVKYIASDRFLDEEGKPVEWELKVLSSEEDEVLRRNCTKRVKVIGNNGKPTGQFTSEIDYNSYVAELCVASTVFPDLKDAELQNSYGVMGEAQLLKTMLTAGEYVNYTVKVNEVNGFDTTFEDKVEEAKN
>CP019857.1|AXU86090.1|1312930_1313401_+|phage-protein
MFQQIKARDTISASKAECYVTIEGKRYNFMQAINLEAKMEKNKSEVPILGSTTKGNKSTGSKYTGSATFHYNTSIFRELLYRYKETGEDIYFDIQVTNEDPTSSAGRQTIILKDCNMDSGIIVKFDADGEYLDEDMDFTCEDWELVEKFNIINGME
>CP019857.1|AXU86089.1|1311603_1312914_+|phage-protein
MALGGGTFVTQNKVLPGAYINFVSATRATSSLSDRGIVAMPLELDWGIDEEIFTVTSDDFEKYSTKYFGYDYTHEKLKGLRDLFKNIRLGYFYKLNKGVKASCSIATAKYSGTRGNDLKVIVTTNIDDNTKFDVVTLLDNKKVDTQIAKVITDLQDNDYITWKKDTTLEASAGLVFTGGTNGESVTGAEYQAFLDKIESYSFNALGSLATTAEIKSLFVEFTKRMRDKVGAKFQTVLYKKNDADYEGVVSVENKVKDTGLLESSLVYWTTGAIAGCDINKSNTNKKYDGEFDVDVNYTQIQLEEALKSGKFIFHKVGDEVHVLEDINTFVSFTDDKNDDFSSNQSVRVLDQIANDIATLFNEKYLGKVPNDKAGRISFWNDVVKHHKELENIRAIEDFKTDDVSVELGNDKKTVIVSDAVKVINAMSKLYMTVSVS
>CP019857.1|AXU86099.1|1318126_1318651_+|hypothetical-protein
MWGKFKKLSLLKKILVIFLIYFVVFTVSMMIHQAIRDSKNRDEVNEGNITKENIISEREKEDIYKQEMQAKVDSMIPEDLKDKTTYYVNILNPTKGEGYIVSIQVENSRFNDENECRNFTKEFVNNIKDMNDIHSVRISFIVDVTLTYNVFLDDWNNIKNNVNLIDDLDFSSGN
>CP019857.1|AXU86100.1|1319134_1319956_+|prophage-antirepressor-related-protein
MKNELMMFEEKKVEVLEYNGQVLFNPYDCGRCLELSDSAIRNHLSKMNDTQAVLLKNSNVLDKDFRKLHNTGEKFLTESGVYKLIFKSKKEEAERFQDWISDEVLPAIRQTGAYITNNADPDKLREKASEIEKLQLAYNSTSMLKELLDGAGFDNKSKLLTAKTLYKKAGIDLPIEINEEEHYFDTKQIASKLKIYSKSNKPAQMAVCEIIKKIDLEENEVKGVWETNGSWTGTVNKYTKSVIDKVRNWIEENNRPAKIAGEKKNYHVVYKIE
>CP019857.1|AXU86101.1|1320018_1320195_+|hypothetical-protein
MCENLLNEYNLKTDEDVEYFVKFATLLYKLKQDNEEKFQEYAEILRGILREQQERENK
>CP019857.1|AXU86102.1|1320560_1321334_+|hypothetical-protein
MGLFSGNESCCICGEKGKQKISDGVICSECLKKYKDTFSIVEPTDVIKKISSEEIKKSIRLTLENKKRFESFNASKKVGIYLLVDENKKQLIISDKISNLNKNKRVYDFRDIISFELLEDDESIIKSGLGGAIGGGLLFGETGAIAGSILGKKKIKTYVNSLKIKITINNIKNSTKYIYLINSKISTNSSLYKESYNYAQEILSTLSIITSSKSIEDKKESISSSTADEILKYKNLLNMEAITQEEFDAKKKELLNL
>CP019857.1|AXU86103.1|1321400_1323689_+|phage-tail-tape-measure-protein
MATIQTSIRIFDGMTPAFRHMTNAMNIVLSSFEQLQRTSSNAIDANSIRTAREELARAEAGFDRLEQQIREADEQQKRFNDDVRKGASSTDKLVENAKRLVATYIGLRSVGGLINLSDQMTSTNARLAMINDGQQSDGGLNKMIFQSAERARASYLDTAKIVSRVGMNAGKAFSSTKEIVAFAEQLNKKFVIAGATTEETNSVLLQLTQGLGSGVLRGEELNAVFESAPNIIQSIADYLEVDIGKIRGMASEGMLTADIVKNSLLSAAEQTNAEFEKMPYTFGQIWTSIKNNAVMIFGVIQKKIEQSMSSRGFRTFIDNFISGLYVLGNVFFNIFNGIISILGSPAFQSFSNTMIVGISLISQALGWIVTQALNLANIFAQNWSIIGPIIAGVVGILGTYLIALGSIWLWETLCKISKNALAIASAIHALAIHAELTETQMATVAQWGLNAAILACPIFWIVAGIIALVAVLFVGVAIFNHFAGTSVSAIGIVAGAISVAAAFVGNLFIATGNLIIDIVALIYNSLANFAEFFANFLDDPIGSVIRAVSRMADAVLGILRSIASAIDTIFGSNLANAVSGWQDKLQGWTDKVAGEAKIKVELMDPNKLHFDRFNCGKAWDAGYKWGDKLETNIKDKFDISKIAEKAKKDLGLDDLWDDKYGLGDGFGSAGLNSPLNDAAKGAKDTAGNTAKMAKTMDKSQEDLKYLRDIAEQETINRFTGVNIKIDMNNTNNISKDTDVDGIVNVLTEKLNDAMIVSAEGIV
>CP019857.1|AXU86104.1|1323704_1324394_+|phage-cell-wall-hydrolase
MAYDFYLDGVQLPIPPPKLEIKVTNKNKTVDLINTGEVNILKKEGLSEISFEAEFTHNKLPFYRGAFRDVQFFLSKLELLKTDCKPFQFIVSRELGNKVLFNTNIKVSLEEYAISEDAENGSDTKVAIKLKQYRDYSTKKLVLAPPKNETGRPNVKIEPKRVDSVNATNTKTYTVKAGDSLWSICQKQLGNGSLYKKVYELNKSMMDKANKGKNLSKYTIYKGQVLKLG
>CP019857.1|AXU86105.1|1324386_1326279_+|phage-cell-wall-hydrolase
MVDELVLANDRDVRLVIAHWEDFYEPAVIDGITWEIERRGTPSKLEFTIVMDDILEFCEGNSVRLYYKGIGIFYGYIFQKKRDKENHIKIVAYDQLRYFKNKDTYVYNNQTASELVKMLAKDFNLKYNVIEDTKYKISRIEENKTLFDMILTALDDTLREKKEMYVLYDDFGRITLKNVASMKLDTVMNNDVIEDFDYNSSIDSDTYTKIKLVRDNEETGKRDVYIAQDSTHMRSWGILQMFDTVDKNMSEAEIKQKCDILLKLYNKKTKSLSLKNVLGDIRVRAGCLVPVFLNLGDIKLQNYMLVEKVKHTFENNSHFMDLTLVDGDEFASYSSSSYSSGNTNNKDEKKNGPAQSTTKKNTGKKVPAIFTAYYPGNNAMEGGKTDCNGKPLDVKSRTVAGPMNREGVKKTWYTDDFLKKHPVFEYGDKVKIILPGTAYDNKVYTVKDNGGRIYVETNGTYHIDILLANASECKKFGRKNGYIIIGGDEEQTYQVEGNNQSSTNNNSKEDKLISIAKSKLGCNYVYGAEGPNNFDCSGFTQWCYKQIGIKIPRTASAQSKAGKAVDLKDRSKWKAGDLLCRIGGGSSNHVVMYIGNNQIIHSPQTGDVVKIESVNSYRKGKAYTHVRRFI
>CP019857.1|AXU86106.1|1326292_1326553_+|phage-protein
MSQDLLQIIKKAAMDAVETSNPMRVVFGTIESISPLRVKIEQKLSIGEIFLIQTDTFKRYTDKKIGDKLVLIRMQGGQQYLILDRM
>CP019857.1|AXU86107.1|1326557_1326977_+|phage-protein
MLPSDNLDYDIEDVSIINFDVRQEPSKTFKLNIEKSKIDGICDDVEALKQTIFLILNTERYQHLIYSWNYGVELNDLIGEPISFVIPELERRIKEALIQDDRVENVDNFEFQNVKGKVHCKFTVYSKYGDIKAEKVVSV
>CP019857.1|AXU86108.1|1326977_1328027_+|phage-protein
MFELMTFENIIKRMLDSVPDTFDKREGSIIYNALAPVAVELTETYIAMDELLDQTFVDTASYYYLEKRCKERGITPLPATNTIAKGVFNIDIPIDSRFNLGEYNYVAIERISEKTYKMKCETAGPIFELGQLIPIEYIDGLETAELTEILINGEDEESEDSLRQRYYDSLNSQSFGGNIQNYKDEVNKLPDVGGVKVYPVWNGGGTVKLVIINSNFKVPSSDLVNLVQEEIDPLQNQGEGLGLAPIGHRVTVEGVTSTTINISAEITYKNGYTWENIKSIAEEAIDDYLNELNMSWEDEENLIVRISQIETRLLSIDGVLDITNTMINEVKSNLTINSNSIVVRCEVVG

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Crispr_ID: CP019857_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_5

1320277-1320431

Orphan

Consensus_repeat	Method
TTATATTAACTAAGTGGTATGTAAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of CP019857_5

>merge|CP019857|5|1320277-1320431|CRISPRCasFinder
TTATATTAACTAAGTGGTATGTAAAGGGAGTAGGCAAGTTTTATAAACAAATAACAGGAAGATTTTATATTAACTATGTGGTATGTAAATGCGTTTAGGAATATGACAGCATCTATTAATACGACAAGTTTTATATTAACTATGTGGACTTAAAA

>CP019857|5|5|1320277-1320431|CRISPRCasFinder
TTATATTAACTAAGTGGTATGTAAA	GGGAGTAGGCAAGTTTTATAAACAAATAACAGGAAGATT
TTATATTAACTATGTGGTATGTAAA	TGCGTTTAGGAATATGACAGCATCTATTAATACGACAAGTT
TTATATTAACTATGTGGACTTAAAA

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86110.1\|1328648_1329425_+\|phage-tail-fiber-protein	unknown	unknown	gnl\|CDD\|372197
CP019857.1\|AXU86100.1\|1319134_1319956_+\|prophage-antirepressor-related-protein	unknown	unknown	gnl\|CDD\|226144
CP019857.1\|AXU86097.1\|1316459_1317326_+\|prophage-antirepressor-related-protein	unknown	unknown	gnl\|CDD\|214989
CP019857.1\|AXU86092.1\|1313986_1314106_+\|phage-protein	unknown	unknown	unknown
CP019857.1\|AXU86093.1\|1314254_1314416_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86107.1\|1326557_1326977_+\|phage-protein	unknown	unknown	gnl\|CDD\|378510
CP019857.1\|AXU86096.1\|1316096_1316339_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86109.1\|1328019_1328637_+\|phage-protein	unknown	unknown	gnl\|CDD\|378379
CP019857.1\|AXU86098.1\|1317380_1317536_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86102.1\|1320560_1321334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373083
CP019857.1\|AXU86094.1\|1315125_1315323_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86108.1\|1326977_1328027_+\|phage-protein	unknown	unknown	gnl\|CDD\|377414
CP019857.1\|AXU86105.1\|1324386_1326279_+\|phage-cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|366353
CP019857.1\|AXU86095.1\|1315297_1315663_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378481
CP019857.1\|AXU86101.1\|1320018_1320195_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86111.1\|1329440_1330901_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86104.1\|1323704_1324394_+\|phage-cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|236880
CP019857.1\|AXU86099.1\|1318126_1318651_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86103.1\|1321400_1323689_+\|phage-tail-tape-measure-protein	unknown	unknown	gnl\|CDD\|131723
CP019857.1\|AXU86106.1\|1326292_1326553_+\|phage-protein	unknown	unknown	gnl\|CDD\|378501

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86110.1\|1328648_1329425_+\|phage-tail-fiber-protein	gnl\|CDD\|372197	pfam12571, DUF3751, Phage tail-collar fibre protein. This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two completely conserved residues (K and W) that may be functionally important. The members are annotated as being putative phage tail or tail-collar proteins.	1.09794e-58
CP019857.1\|AXU86100.1\|1319134_1319956_+\|prophage-antirepressor-related-protein	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	1.12192e-18
CP019857.1\|AXU86097.1\|1316459_1317326_+\|prophage-antirepressor-related-protein	gnl\|CDD\|214989	smart01040, Bro-N, BRO family, N-terminal domain. This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.	2.99127e-10
CP019857.1\|AXU86107.1\|1326557_1326977_+\|phage-protein	gnl\|CDD\|378510	pfam10934, DUF2634, Protein of unknown function (DUF2634). Some members in this family of proteins are annotated as phage related, xkdS however currently there is no known function.	2.99558e-36
CP019857.1\|AXU86109.1\|1328019_1328637_+\|phage-protein	gnl\|CDD\|378379	pfam10076, DUF2313, Uncharacterized protein conserved in bacteria (DUF2313). Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins.	2.4426e-42
CP019857.1\|AXU86102.1\|1320560_1321334_+\|hypothetical-protein	gnl\|CDD\|373083	pfam14471, DUF4428, Domain of unknown function (DUF4428). This putative zinc finger domain is found in uncharacterized bacterial proteins.	0.000598973
CP019857.1\|AXU86108.1\|1326977_1328027_+\|phage-protein	gnl\|CDD\|377414	pfam04865, Baseplate_J, Baseplate J-like protein. The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologs, which are thought to have been horizontally transferred.	8.97207e-52
CP019857.1\|AXU86104.1\|1323704_1324394_+\|phage-cell-wall-hydrolase	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	3.76553e-11
CP019857.1\|AXU86095.1\|1315297_1315663_-\|hypothetical-protein	gnl\|CDD\|378481	pfam10711, DUF2513, Hypothetical protein (DUF2513). This family is found in bacteria. The function is not known.	1.6383e-27
CP019857.1\|AXU86105.1\|1324386_1326279_+\|phage-cell-wall-hydrolase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.93424e-27
CP019857.1\|AXU86103.1\|1321400_1323689_+\|phage-tail-tape-measure-protein	gnl\|CDD\|131723	TIGR02675, Mu-like_prophage_FluMu_protein_gp42, tape measure domain. Proteins containing this domain are strictly bacterial, including bacteriophage and prophage regions of bacterial genomes. Most members are 800 to 1800 amino acids long, making them among the longest predicted proteins of their respective phage genomes, where they are encoded in tail protein regions. This roughly 80-residue domain described here usually begins between residue 100 and 250. Many members are known or predicted to act as phage tail tape measure proteins, a minor tail component that regulates tail length.	2.06458e-14
CP019857.1\|AXU86106.1\|1326292_1326553_+\|phage-protein	gnl\|CDD\|378501	pfam10844, DUF2577, Protein of unknown function (DUF2577). This family of proteins has no known function.	3.68145e-19

>CP019857.1|AXU86101.1|1320018_1320195_+|hypothetical-protein
MCENLLNEYNLKTDEDVEYFVKFATLLYKLKQDNEEKFQEYAEILRGILREQQERENK
>CP019857.1|AXU86100.1|1319134_1319956_+|prophage-antirepressor-related-protein
MKNELMMFEEKKVEVLEYNGQVLFNPYDCGRCLELSDSAIRNHLSKMNDTQAVLLKNSNVLDKDFRKLHNTGEKFLTESGVYKLIFKSKKEEAERFQDWISDEVLPAIRQTGAYITNNADPDKLREKASEIEKLQLAYNSTSMLKELLDGAGFDNKSKLLTAKTLYKKAGIDLPIEINEEEHYFDTKQIASKLKIYSKSNKPAQMAVCEIIKKIDLEENEVKGVWETNGSWTGTVNKYTKSVIDKVRNWIEENNRPAKIAGEKKNYHVVYKIE
>CP019857.1|AXU86099.1|1318126_1318651_+|hypothetical-protein
MWGKFKKLSLLKKILVIFLIYFVVFTVSMMIHQAIRDSKNRDEVNEGNITKENIISEREKEDIYKQEMQAKVDSMIPEDLKDKTTYYVNILNPTKGEGYIVSIQVENSRFNDENECRNFTKEFVNNIKDMNDIHSVRISFIVDVTLTYNVFLDDWNNIKNNVNLIDDLDFSSGN
>CP019857.1|AXU86098.1|1317380_1317536_+|hypothetical-protein
MCENLLDMDRIELIRELGSIFEKMRNENPDKFYRFVSLVKEECRKKEEKNK
>CP019857.1|AXU86097.1|1316459_1317326_+|prophage-antirepressor-related-protein
MKNLIVKEFNGSQIYTFMWKEKSCWIANQIVGLFDYADVSKTIQDCIKAEDFEIEQEYDVLKGNEFNDFVTTLNVVANNIISNKARSITIFYEDGLYGFLQYTDKPIGVQFRKWLRREVLPAIRQHGAYITNNADPQALREKANEIESLDTVNKTIEILTPFLDNAGIDEKAKLLTAKTIYKKAGIELPLEIEEKEHFFDTVQIATKLNVYSKSNKPAFHAIGEIIKKLDIQDNEKLVVLESKRGWSGSVNKYSQSVIDKIRHWIEENNRPTKIQGEKKNFHVVYKIE
>CP019857.1|AXU86096.1|1316096_1316339_+|hypothetical-protein
MTVTRYNVIINVTSYRKEVNKIATKSRAEYMKNRRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDEELEQKE
>CP019857.1|AXU86095.1|1315297_1315663_-|hypothetical-protein
MKRDLELIRDILIKMEESDADRMSISDFMTDVYDERTISYHLQLLLDVGFIEATPMGVQRCLYKHYIVKRITSFGYDYLDNIRDDTVWNKTKKQLGNFASSASLKVIGSVASSVILKMIGV
>CP019857.1|AXU86094.1|1315125_1315323_+|hypothetical-protein
MNKDIEFIACSMRLKILIQAREDLIENINKYSTKSYEKNIDNYKKLDMIFEDAIKFEAILLSSLK
>CP019857.1|AXU86093.1|1314254_1314416_+|hypothetical-protein
MDNFLIGVLASLTASLIGYIVCLCIKKVKSHSVQESDLDVELKFSFKFKKNKH
>CP019857.1|AXU86092.1|1313986_1314106_+|phage-protein
MGLEINERALAAASILIKIEDEEEAMKEAERERKRGRRR
>CP019857.1|AXU86102.1|1320560_1321334_+|hypothetical-protein
MGLFSGNESCCICGEKGKQKISDGVICSECLKKYKDTFSIVEPTDVIKKISSEEIKKSIRLTLENKKRFESFNASKKVGIYLLVDENKKQLIISDKISNLNKNKRVYDFRDIISFELLEDDESIIKSGLGGAIGGGLLFGETGAIAGSILGKKKIKTYVNSLKIKITINNIKNSTKYIYLINSKISTNSSLYKESYNYAQEILSTLSIITSSKSIEDKKESISSSTADEILKYKNLLNMEAITQEEFDAKKKELLNL
>CP019857.1|AXU86103.1|1321400_1323689_+|phage-tail-tape-measure-protein
MATIQTSIRIFDGMTPAFRHMTNAMNIVLSSFEQLQRTSSNAIDANSIRTAREELARAEAGFDRLEQQIREADEQQKRFNDDVRKGASSTDKLVENAKRLVATYIGLRSVGGLINLSDQMTSTNARLAMINDGQQSDGGLNKMIFQSAERARASYLDTAKIVSRVGMNAGKAFSSTKEIVAFAEQLNKKFVIAGATTEETNSVLLQLTQGLGSGVLRGEELNAVFESAPNIIQSIADYLEVDIGKIRGMASEGMLTADIVKNSLLSAAEQTNAEFEKMPYTFGQIWTSIKNNAVMIFGVIQKKIEQSMSSRGFRTFIDNFISGLYVLGNVFFNIFNGIISILGSPAFQSFSNTMIVGISLISQALGWIVTQALNLANIFAQNWSIIGPIIAGVVGILGTYLIALGSIWLWETLCKISKNALAIASAIHALAIHAELTETQMATVAQWGLNAAILACPIFWIVAGIIALVAVLFVGVAIFNHFAGTSVSAIGIVAGAISVAAAFVGNLFIATGNLIIDIVALIYNSLANFAEFFANFLDDPIGSVIRAVSRMADAVLGILRSIASAIDTIFGSNLANAVSGWQDKLQGWTDKVAGEAKIKVELMDPNKLHFDRFNCGKAWDAGYKWGDKLETNIKDKFDISKIAEKAKKDLGLDDLWDDKYGLGDGFGSAGLNSPLNDAAKGAKDTAGNTAKMAKTMDKSQEDLKYLRDIAEQETINRFTGVNIKIDMNNTNNISKDTDVDGIVNVLTEKLNDAMIVSAEGIV
>CP019857.1|AXU86104.1|1323704_1324394_+|phage-cell-wall-hydrolase
MAYDFYLDGVQLPIPPPKLEIKVTNKNKTVDLINTGEVNILKKEGLSEISFEAEFTHNKLPFYRGAFRDVQFFLSKLELLKTDCKPFQFIVSRELGNKVLFNTNIKVSLEEYAISEDAENGSDTKVAIKLKQYRDYSTKKLVLAPPKNETGRPNVKIEPKRVDSVNATNTKTYTVKAGDSLWSICQKQLGNGSLYKKVYELNKSMMDKANKGKNLSKYTIYKGQVLKLG
>CP019857.1|AXU86105.1|1324386_1326279_+|phage-cell-wall-hydrolase
MVDELVLANDRDVRLVIAHWEDFYEPAVIDGITWEIERRGTPSKLEFTIVMDDILEFCEGNSVRLYYKGIGIFYGYIFQKKRDKENHIKIVAYDQLRYFKNKDTYVYNNQTASELVKMLAKDFNLKYNVIEDTKYKISRIEENKTLFDMILTALDDTLREKKEMYVLYDDFGRITLKNVASMKLDTVMNNDVIEDFDYNSSIDSDTYTKIKLVRDNEETGKRDVYIAQDSTHMRSWGILQMFDTVDKNMSEAEIKQKCDILLKLYNKKTKSLSLKNVLGDIRVRAGCLVPVFLNLGDIKLQNYMLVEKVKHTFENNSHFMDLTLVDGDEFASYSSSSYSSGNTNNKDEKKNGPAQSTTKKNTGKKVPAIFTAYYPGNNAMEGGKTDCNGKPLDVKSRTVAGPMNREGVKKTWYTDDFLKKHPVFEYGDKVKIILPGTAYDNKVYTVKDNGGRIYVETNGTYHIDILLANASECKKFGRKNGYIIIGGDEEQTYQVEGNNQSSTNNNSKEDKLISIAKSKLGCNYVYGAEGPNNFDCSGFTQWCYKQIGIKIPRTASAQSKAGKAVDLKDRSKWKAGDLLCRIGGGSSNHVVMYIGNNQIIHSPQTGDVVKIESVNSYRKGKAYTHVRRFI
>CP019857.1|AXU86106.1|1326292_1326553_+|phage-protein
MSQDLLQIIKKAAMDAVETSNPMRVVFGTIESISPLRVKIEQKLSIGEIFLIQTDTFKRYTDKKIGDKLVLIRMQGGQQYLILDRM
>CP019857.1|AXU86107.1|1326557_1326977_+|phage-protein
MLPSDNLDYDIEDVSIINFDVRQEPSKTFKLNIEKSKIDGICDDVEALKQTIFLILNTERYQHLIYSWNYGVELNDLIGEPISFVIPELERRIKEALIQDDRVENVDNFEFQNVKGKVHCKFTVYSKYGDIKAEKVVSV
>CP019857.1|AXU86108.1|1326977_1328027_+|phage-protein
MFELMTFENIIKRMLDSVPDTFDKREGSIIYNALAPVAVELTETYIAMDELLDQTFVDTASYYYLEKRCKERGITPLPATNTIAKGVFNIDIPIDSRFNLGEYNYVAIERISEKTYKMKCETAGPIFELGQLIPIEYIDGLETAELTEILINGEDEESEDSLRQRYYDSLNSQSFGGNIQNYKDEVNKLPDVGGVKVYPVWNGGGTVKLVIINSNFKVPSSDLVNLVQEEIDPLQNQGEGLGLAPIGHRVTVEGVTSTTINISAEITYKNGYTWENIKSIAEEAIDDYLNELNMSWEDEENLIVRISQIETRLLSIDGVLDITNTMINEVKSNLTINSNSIVVRCEVVG
>CP019857.1|AXU86109.1|1328019_1328637_+|phage-protein
MDKEINLINYLPQILQDKEEYIKVFNVENKEIKTLHEKLNDLSNDQFLEDLTPSGIKRWEKIMSITPKSNESLEDRRFRIFSKYISKLPYSERFLRNWLDNVVGEGNYELTINNATYNIHLESDARNQDWFEEVHSFVSSIKPCNMTLDYTRVLVSKDNYMNFGITTLIGQEITIYPWSPPDIETYGEIDVLTGNGVGYQEITIF
>CP019857.1|AXU86110.1|1328648_1329425_+|phage-tail-fiber-protein
MAIDKSYYTIITDVGKAKIANASITGNKVGFVKIQLGDGGGSEYTPTESQTALKNVVWEGNIGNTTTDETAPNCIILESLIPSSVGGFMIREIGYLDDENNLIAISKYKECYKPSIEQGAVVDMKVKTVLIVSNVNNIELKIDPTIIFATLKDIQDLETKIGTVNTKIDTTKTELNSKVGDTTLLTTTDKTNIVNALNEVKKTSVDSIETTAEKTSYNNATSKLNATNVQGAIDEIVAEVRGNRSSIISSINDNLIPM
>CP019857.1|AXU86111.1|1329440_1330901_+|hypothetical-protein
MPPAETFICNRIVKKRRGYYSERDVFLSPCPYVYGEGGMYESTYYGEFDLSNSKYITVPTSTKYEKTATRVYFISGGNMITSSSGMKQAITLELIPDPNIIINDDLGVISDSCNINYRIPDSNTSVKFDVTEKLNGVVISKKNYALDGNYTLNLTDEHLSTLSFNSTNNITIELSTYQGGKFLEKTVTFTKGNTKPKLNITSYNSTTAIFTAIDIDNNLSKIEWFIDDVLKETITTDLYLEKTINYELTDNAIHTLKIVATDAENATVEKVLSISKEIMPLQEDASLSDISTKLAEIGEEFRNGKTSIINTLALKNIEASLNNTLVELSEKIKTSFDSSDASVQDLQNRITELNNQLSQRKKWATGRYTFTDLDISNFTLNSESIVQTKSIITDLSFTPSIIIIDSIQMKSGTDRVYFRSITNLDITIGAKYTNSSLPVGGSGYIYIQKPTPSNNFLLILTRLDGQGREISFSPIVGETLTWYAFE

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Crispr_ID: CP019857_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_6

1535237-1536121

Orphan

I-A

Consensus_repeat	Method
GTTTTATATTAACTAAGTGGTATGTAAAT	PILER-CR
GTTTTATATTAACTAAGTGGTATGTAAAT	CRISPRCasFinder
GTTTTATATTAACTAAGTGGTATGTAAAT	CRT

13 spacers

The CRISPR arrays of CP019857_6

>merge|CP019857|6|1535237-1536121|PILER-CR,CRISPRCasFinder,CRT
GTTTTATATTAACTAAGTGGTATGTAAATTGAAAATCTAGTTAAAAACTGCATCAAAGTATTGATGTTTTATATTAACTAAGTGGTATGTAAATCAGCAAGAGTCGCAACAACATTAACAACTTCGGGAGCGTTTTATATTAACTAAGTGGTATGTAAATTTGTATTATTACTTTTTATCAGAATAATCAAAAGATAGTTTTATATTAACTAAGTGGTATGTAAATGCAGAAGAAACAGGTTTCAAAACGATAAAAAAATAATGTTTTATATTAACTAAGTGGTATGTAAATAGAGAGAAGGGCTATTCTCTCTAGGCTTATCCTTACAAGTTTTATATTAACTAAGTGGTATGTAAATAAACCAATCTTTTTTCCTTGAATCTTTTAAAAGTTCCGTTTTATATTAACTAAGTGGTATGTAAATGATTTTAGAACTTCATCCACAAACGAGCTTTCTACAGTTTTATATTAACTAAGTGGTATGTAAATATAGTCCTTTTCTAAATTTAGAATCAAGTTTTGGAGTGTTTTATATTAACTAAGTGGTATGTAAATAGAGTAAAACAATAGTACAAGAACAAATAAATACATGTTTTATATTAACTAAGTGGTATGTAAATACTTTTTCACGACATTTTTTTATAAAAGGAGGTATTAGTTTTATATTAACTAAGTGGTATGTAAATAAAATTATAGACAGAATGATAAATGTATTTGATGCTTGTTTTATATTAACTAAGTGGTATGTAAATTAACTTTATAAAACCCAGTAATTGCAACACTTTTATAGTTTTATATTAACTAAGTGGTATGTAAATAGTATAATGTTGAAAAGTTAGAGAGTACAATCAAGGAATTTTACATTAACTAAAATGTATAGAATA

>CP019857|6|4|1535237-1536055|PILER-CR
GTTTTATATTAACTAAGTGGTATGTAAAT	TGAAAATCTAGTTAAAAACTGCATCAAAGTATTGAT
GTTTTATATTAACTAAGTGGTATGTAAAT	CAGCAAGAGTCGCAACAACATTAACAACTTCGGGAGC
GTTTTATATTAACTAAGTGGTATGTAAAT	TTGTATTATTACTTTTTATCAGAATAATCAAAAGATA
GTTTTATATTAACTAAGTGGTATGTAAAT	GCAGAAGAAACAGGTTTCAAAACGATAAAAAAATAAT
GTTTTATATTAACTAAGTGGTATGTAAAT	AGAGAGAAGGGCTATTCTCTCTAGGCTTATCCTTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAACCAATCTTTTTTCCTTGAATCTTTTAAAAGTTCC
GTTTTATATTAACTAAGTGGTATGTAAAT	GATTTTAGAACTTCATCCACAAACGAGCTTTCTACA
GTTTTATATTAACTAAGTGGTATGTAAAT	ATAGTCCTTTTCTAAATTTAGAATCAAGTTTTGGAGT
GTTTTATATTAACTAAGTGGTATGTAAAT	AGAGTAAAACAATAGTACAAGAACAAATAAATACAT
GTTTTATATTAACTAAGTGGTATGTAAAT	ACTTTTTCACGACATTTTTTTATAAAAGGAGGTATTA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAATTATAGACAGAATGATAAATGTATTTGATGCTT
GTTTTATATTAACTAAGTGGTATGTAAAT	TAACTTTATAAAACCCAGTAATTGCAACACTTTTATA
GTTTTATATTAACTAAGTGGTATGTAAAT

>CP019857|6|6|1535237-1536121|CRISPRCasFinder
GTTTTATATTAACTAAGTGGTATGTAAAT	TGAAAATCTAGTTAAAAACTGCATCAAAGTATTGAT
GTTTTATATTAACTAAGTGGTATGTAAAT	CAGCAAGAGTCGCAACAACATTAACAACTTCGGGAGC
GTTTTATATTAACTAAGTGGTATGTAAAT	TTGTATTATTACTTTTTATCAGAATAATCAAAAGATA
GTTTTATATTAACTAAGTGGTATGTAAAT	GCAGAAGAAACAGGTTTCAAAACGATAAAAAAATAAT
GTTTTATATTAACTAAGTGGTATGTAAAT	AGAGAGAAGGGCTATTCTCTCTAGGCTTATCCTTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAACCAATCTTTTTTCCTTGAATCTTTTAAAAGTTCC
GTTTTATATTAACTAAGTGGTATGTAAAT	GATTTTAGAACTTCATCCACAAACGAGCTTTCTACA
GTTTTATATTAACTAAGTGGTATGTAAAT	ATAGTCCTTTTCTAAATTTAGAATCAAGTTTTGGAGT
GTTTTATATTAACTAAGTGGTATGTAAAT	AGAGTAAAACAATAGTACAAGAACAAATAAATACAT
GTTTTATATTAACTAAGTGGTATGTAAAT	ACTTTTTCACGACATTTTTTTATAAAAGGAGGTATTA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAATTATAGACAGAATGATAAATGTATTTGATGCTT
GTTTTATATTAACTAAGTGGTATGTAAAT	TAACTTTATAAAACCCAGTAATTGCAACACTTTTATA
GTTTTATATTAACTAAGTGGTATGTAAAT	AGTATAATGTTGAAAAGTTAGAGAGTACAATCAAGGA
ATTTTACATTAACTAAAATGTATAGAATA

>CP019857|6|3|1535237-1536055|CRT
GTTTTATATTAACTAAGTGGTATGTAAAT	TGAAAATCTAGTTAAAAACTGCATCAAAGTATTGAT
GTTTTATATTAACTAAGTGGTATGTAAAT	CAGCAAGAGTCGCAACAACATTAACAACTTCGGGAGC
GTTTTATATTAACTAAGTGGTATGTAAAT	TTGTATTATTACTTTTTATCAGAATAATCAAAAGATA
GTTTTATATTAACTAAGTGGTATGTAAAT	GCAGAAGAAACAGGTTTCAAAACGATAAAAAAATAAT
GTTTTATATTAACTAAGTGGTATGTAAAT	AGAGAGAAGGGCTATTCTCTCTAGGCTTATCCTTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAACCAATCTTTTTTCCTTGAATCTTTTAAAAGTTCC
GTTTTATATTAACTAAGTGGTATGTAAAT	GATTTTAGAACTTCATCCACAAACGAGCTTTCTACA
GTTTTATATTAACTAAGTGGTATGTAAAT	ATAGTCCTTTTCTAAATTTAGAATCAAGTTTTGGAGT
GTTTTATATTAACTAAGTGGTATGTAAAT	AGAGTAAAACAATAGTACAAGAACAAATAAATACAT
GTTTTATATTAACTAAGTGGTATGTAAAT	ACTTTTTCACGACATTTTTTTATAAAAGGAGGTATTA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAATTATAGACAGAATGATAAATGTATTTGATGCTT
GTTTTATATTAACTAAGTGGTATGTAAAT	TAACTTTATAAAACCCAGTAATTGCAACACTTTTATA
GTTTTATATTAACTAAGTGGTATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86298.1\|1523410_1523995_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376406
CP019857.1\|AXU86307.1\|1533732_1533978_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86303.1\|1528911_1529340_+\|EamA-like-transporter-family-protein	unknown	unknown	gnl\|CDD\|377396
CP019857.1\|AXU86316.1\|1545900_1546266_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
CP019857.1\|AXU86311.1\|1542313_1543123_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
CP019857.1\|AXU86305.1\|1530192_1531548_-\|drug/sodium-antiporter	unknown	unknown	gnl\|CDD\|240548
CP019857.1\|AXU86312.1\|1543267_1543507_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86314.1\|1544374_1545049_-\|MgtC/SapB-transporter	unknown	unknown	gnl\|CDD\|224204
CP019857.1\|AXU86315.1\|1545268_1545823_-\|isochorismatase	unknown	unknown	gnl\|CDD\|238496
CP019857.1\|AXU86301.1\|1527157_1528144_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224163
CP019857.1\|AXU86302.1\|1528211_1528760_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86310.1\|1539295_1541530_-\|signaling-protein	unknown	unknown	gnl\|CDD\|238923
CP019857.1\|AXU86313.1\|1543693_1543870_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86317.1\|1546496_1546631_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86309.1\|1538419_1539265_-\|signaling-protein	unknown	unknown	gnl\|CDD\|143635
CP019857.1\|AXU86308.1\|1536446_1538180_-\|signaling-protein	unknown	unknown	gnl\|CDD\|143635
CP019857.1\|AXU86306.1\|1532456_1532684_-\|phage-integrase	unknown	unknown	gnl\|CDD\|379665
CP019857.1\|AXU86300.1\|1525942_1526887_+\|membrane-protein	unknown	unknown	gnl\|CDD\|273359
CP019857.1\|AXU86299.1\|1524194_1525625_-\|sigma-54-dependent-regulatory-protein	unknown	unknown	gnl\|CDD\|226350
CP019857.1\|AXU86304.1\|1529424_1530075_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|238952

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86298.1\|1523410_1523995_-\|hypothetical-protein	gnl\|CDD\|376406	pfam00882, Zn_dep_PLPC, Zinc dependent phospholipase C.	9.21275e-20
CP019857.1\|AXU86303.1\|1528911_1529340_+\|EamA-like-transporter-family-protein	gnl\|CDD\|377396	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ. DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.	2.2504e-17
CP019857.1\|AXU86316.1\|1545900_1546266_-\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.48025e-25
CP019857.1\|AXU86311.1\|1542313_1543123_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	4.54289e-25
CP019857.1\|AXU86305.1\|1530192_1531548_-\|drug/sodium-antiporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	8.22246e-115
CP019857.1\|AXU86314.1\|1544374_1545049_-\|MgtC/SapB-transporter	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.38574e-53
CP019857.1\|AXU86315.1\|1545268_1545823_-\|isochorismatase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	2.06279e-56
CP019857.1\|AXU86301.1\|1527157_1528144_-\|radical-SAM-protein	gnl\|CDD\|224163	COG1242, COG1242, Predicted Fe-S oxidoreductase [General function prediction only].	3.10212e-179
CP019857.1\|AXU86310.1\|1539295_1541530_-\|signaling-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	3.35915e-92
CP019857.1\|AXU86309.1\|1538419_1539265_-\|signaling-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.16166e-29
CP019857.1\|AXU86308.1\|1536446_1538180_-\|signaling-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.55542e-46
CP019857.1\|AXU86306.1\|1532456_1532684_-\|phage-integrase	gnl\|CDD\|379665	pfam14659, Phage_int_SAM_3, Phage integrase, N-terminal SAM-like domain. This domain is found in a variety of phage integrase proteins.	0.00489111
CP019857.1\|AXU86300.1\|1525942_1526887_+\|membrane-protein	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.85297e-26
CP019857.1\|AXU86299.1\|1524194_1525625_-\|sigma-54-dependent-regulatory-protein	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	8.37174e-137
CP019857.1\|AXU86304.1\|1529424_1530075_+\|ATP-binding-protein	gnl\|CDD\|238952	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins is predicted to bind ATP. This domainhas a strongly conserved motif SGGKD at the N terminus.	4.77904e-55

>CP019857.1|AXU86307.1|1533732_1533978_-|hypothetical-protein
MNQKKIKISIKMVIIGIFAVIISFVLSRLFVEYIDELLRSNWQYQLFESESSYIIFANCIMFSNILLEIFLIYICRKFRKI
>CP019857.1|AXU86306.1|1532456_1532684_-|phage-integrase
MIKNQIEVFFKDMKLIDITPSILQSYINNIYNEHMLNSTKNQVDFIKLVLKESYRLKEISENICDFVTTPIKKIV
>CP019857.1|AXU86305.1|1530192_1531548_-|drug/sodium-antiporter
MDTKISINENMSLGKRFFKYLAPSVVAMWVFSLYTMVDGIFVSKGVGELALAAVNISMPFINFIFAVSLLFSTGASTIIAIYLGKKDIKSANEVFSFNLVSIIILSIIILAITFFNLDRLALFLGATESTIGMVKDYLGIIIFFNGFFIVSYSLEVIIKTDGFPILATVGVIISALTNIILDYLFVIEFGWGVKGAGIATGLSQVFSTIFFLIHFLRKNSTLNFSKFRIDFKTLRKIVFIGFPDSTTELSCGIVVLLFNLSLTKYIGENALIYYSVINYINTLVLMTMMGITQGMQPLTSFYYGAGNIDNVKKLLKMGIKATIIASVAVFVICMAFSGPIVSLFIHPEETMLFNEGVRVFKIFSISFLLVGINVIISGFFVSVEKPSISTVISLGRGLVIVVLSLISMILIFGGQGIWMTTIVSEFICLILSLAFLKKNFSTLDSNLNKVA
>CP019857.1|AXU86304.1|1529424_1530075_+|ATP-binding-protein
MADEKFVMSFSGGKDSILALNRMLKKGYKPVALLTTISEEHGKSWTHNLEYNMLKQVSSNIGLPLLVAECGVEGYEESFERALIKAKNMGATICAYGDIDIESHRKWDTDRCEAVGMKVDLPLWQESREDLVYEFIDSGFCSVVTKVNLKHLGEEFLGKKLTRELVENIKNAGADPCGEHGEYHTFVVDGPIFKKPVEYEVKGTLIKDGYGYLEIK
>CP019857.1|AXU86303.1|1528911_1529340_+|EamA-like-transporter-family-protein
MTKLWAIIFALLAGGSTALEAFINGELGKSTTALVATFISLTVGAIFFLASIIVTGDLKCLVSINGFNYKLLLGGVFGGLIIYFTVKAIPNLGVSNTLILTLVSQVLVGFFIDSVILGQETMHLYKYIGVILLILGTFFIVN
>CP019857.1|AXU86302.1|1528211_1528760_-|hypothetical-protein
MYTNFNIDFNNFNKKENAIKFMLMGVLLIILGLLCLTFKTLGIKLISWTFGIALLFFAYLNLKNINELKRYATKEEIKPSINIQWVLIIACILLFVFPQKIQSIFSLFLGFYLIFNQLVALVNSKNNPYSKFTTWNIVKILFGICLILSPLFLSRFIVSIMSFFIILFGLVLFFSGNTARKY
>CP019857.1|AXU86301.1|1527157_1528144_-|radical-SAM-protein
MFFVQAQRTILLEIGDFLDKFKYAFDNKRYHTWNYYLRNTFGEKVFKVSINAGFTCPNIDGSLGYGGCTYCSKEGSGDFAGNPKDNLISQFYNIKEMMLKKWPHAKYIGYFQAYTNTYAPLEVLKEKYETILELEDVIGLSISTRPDCLPDDVVEYLSELNKRTNLWVELGLQTIHDSTSKIINRGHDYKTFVEGVEKLKSKNIKVVVHIINGLPGEDYNMMVETAKAVGKMGVDGIKIHLLHVIKDTPMEKMLQNGMLTLMEQDEYINLVCDQLEILPETMIIHRLTGDGKRDELVGPIWSLKKWEILNQIDDTLKARNSYQGCKFV
>CP019857.1|AXU86300.1|1525942_1526887_+|membrane-protein
MGEKSKGYVFIAIAGLLWATLGLFGKFLMGNGLTSEQVAFTRLFFGFIVLGVYSSIRTPQILKISKKGIIYSVIIGIICQAMFNLCYFKAIDIAGVSIAAVLLYTSPLFLAIFSKICYKENITRSKLFSLILCFIGAIMAVTGGRLDFQGLNAFGLLLGVLSAIAYALMPTISKNALKEFSSSTILVYSFLFGAIFMIPSSRPWEILNYAKDLDVLSCMLMLGIVPAALAYIFYAAGISKGVELSVAGVVASVELVGSVIIGCTILGESFSLGKLFGVMLMLISAVVALNLSYDEIRIFYKSNKLKQIEKTESI
>CP019857.1|AXU86299.1|1524194_1525625_-|sigma-54-dependent-regulatory-protein
MNLDLEFYQKILEASHDEICVSDDKGIIIYCNKAFEENYGLKKEDILGKNVSFLEDSGYSTKSPIPIVLKTKTKFSLEQDTQTGKKLIITATPIFDENGNLEFTVENCRDITELNNIKNKLEDTKKQVKKYKSEVETLYRTALRIEDTVIMDGIVMRPIINTVNHVSKTDVSVLLLGESGTGKSSLARYIHHNSNRSNGPFITINCATISPQLLESELFGYTSGAFTGASTKGKVGLVELANGGTLFLDEIGDIPQNLQAKFLQLIQDRTFTPVGSLKNKKVDIRIISATNVDLVSKVKEKKFREDLYYRLNVIEIKLPPLRERRDNLVEIIKYYFNRYSSDFNLNKTISKEAMDAIANYRFPGNIRELQNIIQKILLTCTDNHITIDDLPNILTKNIHITNNGNKTHISQINKVIISDSKSTNYKNKNFDTLIKEYEKNIILDAYEKFGSSYKVAKHLEISQSKANRLIRKYTNT
>CP019857.1|AXU86298.1|1523410_1523995_-|hypothetical-protein
MLMNTHFIMAKSILDNIDENKTFFISEKNFIYGNIKPDAFSKYKLKKHYLDESFNMIVSKINYLCSLNIDSLSKYFSVSRLSQELGVICHFLCDFFCVAHSERWEFKHSLNKHVTYERELGAFAKDVDLSKIKCGTINSSFEKFFTKLYSDYKKKTDYMNDLKFSAYTCNSVINYILDSILSNTIKSYHIANCG
>CP019857.1|AXU86308.1|1536446_1538180_-|signaling-protein
MSILLKKAPKLAKHIITSFYINRDIDEVLKYLCENVTWIGPGEQEFLTSFNEIKNYFYAGQDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENAQMILEVNQRCTFEIIEDRGKLLIKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTEVIEMITNNINGGLKGSNDDSTYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPDLPKALEDCERCFAKGPTYSSEYRIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDITQLKNIESELKLERERYRIALQNITDIMFEYDIENDTLIKYQRVEIDKKIELENFETKNYSKLLESGKIIHLDDIGKLLEVLHGNLRETIEIRQVNSLTKNEWRWIRVQCSVIYDSDHNPIKTIGVLKDITEDKSKLESLINQAQRDPLTQLYNQRVSQNLIEEYLCSSDSKNNDALLVIDIDDFKTVNDTFGHLEGNEVLVAVSKILLHNTHDKDIVARIGGDEFTIFIKSLTKDLIIKITNDILNDASKIKVKDNHKITLSIGIAFTDDSTKLYKDLFSKADKALYLSKADGKNCYSTYE
>CP019857.1|AXU86309.1|1538419_1539265_-|signaling-protein
MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLGMTNIEIAKKLPDNIAKFFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYKVDVDEKTYIITMANDITKLYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVLIDLDNFKMINDYEGHNVGDKILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKNYVYSQLEALRENFLKVFSKYKYLSFSYGVDTVKRNLKLTIVELDKKMYKNKEKNKKKFDKNDY
>CP019857.1|AXU86310.1|1539295_1541530_-|signaling-protein
MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNREFMYQHIDDCISKNIHIGIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKGIVAYLKGEGFLIVLPNVSNKELNNMGATIIESARELKIKLPNEKEIYSNVTFSIGSTIWNGEPNMTTLMLFNQVYSALKKAKSEGKNRYILFDFKDNSFYNKLENDKEFLSEISHVLQTKQIEVFYQPLYNIKNNTIVGCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDLHLFEENCKNIRRWIDNNDVFVPICCNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIEITENILIENTNTIIQQLAELRSYGFSVSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLSHNLNDFKNTTILYSIINIARALGMLTVCEGVETEQHVEFIKSINCDIAQGYYYAKPMECKEFEKLLSKENNSKKMFIKYSDIGKSLIEKIFDGFFIMQDMKKLRANVTEDIQWFDFYNKTEITSFPKVIEHFEKHIKGKKFSILYKSITPHNTESDSLLISGEAVLSDEASEHQKYSNFYFSANCIISENKLLLAKLHLDLIKTAGYINEFESYSIPKMTNTHLDESNILSQFYSMLPVGIIRYDLFGDMIITYMNEEMFDIIGYTKEQFFGEMGGNLRAIVHPDDLDFVYKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLSAIDGRSIAQGMYVDVNKIKNLTKI
>CP019857.1|AXU86311.1|1542313_1543123_+|MerR-family-transcriptional-regulator
MKDYYKIGEISKIYGIGRDSLMYYEEIGILRPVRDINGYRMYNISDIWKLNLIKEFRSLNFPMKKIKEYLDDRSIESTKNILNEELDLIDKKIAEFISHKENIIKRLSSIESVIQNTKIDEIEVVYIEKRKALELNADIKRDEDFDFLIQKLQKEYEDRFNILGNNNIGSAFSTEAINKGIFNEFKSVFCFLESNEKVYNIVFDEGYYVTLNYTGSNSNNKMYMEKVFKFIEENNYKIIADPIEIYKIDIHETGIVEEFVTEIQVPITK
>CP019857.1|AXU86312.1|1543267_1543507_+|hypothetical-protein
MKCSNCGSVNIEKGILTTGGIYAETIGLKYRGDGKLDKVINKTFPVQSTIYSDLCLDCGEIVRTYIKDNTDRNWCKDKK
>CP019857.1|AXU86313.1|1543693_1543870_-|hypothetical-protein
MFRDEMDKCTHMLTAYISSLYDYCDFIDTQLDDFILEYGENVVESCLHQVMVLVSKYN
>CP019857.1|AXU86314.1|1544374_1545049_-|MgtC/SapB-transporter
MNHHILIQFEYIARIITAGFCGALIGYERKNRLKEAGIRTHFIVALASALIIIVSKYGFNDIVGTPGIGLDPARVAAQVVSGIGFLGAGLIFIRNQSVSGLTTAAGIWATAGTGLAIGSGLYLVGIVSSIIIVIVQITLHRDRKWMKLPTAEQVSLKISNSTDSIEYIEGKFKKSNIEIINMNIKRLDGDWLEVVIYTKLPKGYKKTNLLKLFSDNPLIETLEI
>CP019857.1|AXU86315.1|1545268_1545823_-|isochorismatase
MSIALILIDIQNDYFKNGKCELFQSEETAENAKKILLFFRKNNLPVIHIQHISTDKTASFFLPNTHGSEINKIVFPLDNEEIIIKHTPDSFFETDLQSILDKKNITNLVICGMMSHMCIDTSVRTAKKLRYDITLISDACTTKNLSWNNIEINANTVHQVFMASLQNSFADVKNTDKFLSNYHK
>CP019857.1|AXU86316.1|1545900_1546266_-|transcriptional-regulator
MKIRAEYTCPLEIVHDIIKGKWKTILIFELRQSNKTFSELQHNIYGINQKMLIQQLKELRDFGIIDKISSAGYPLHVEYFLTNRGKKMLKAVEIMQEIGIEYMLEHGQQEILDNKGICYNK
>CP019857.1|AXU86317.1|1546496_1546631_+|hypothetical-protein
MNISRKAMKIIELAQKIANKRGISVEEAWSEAVTEYKNKYEHIA

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Crispr_ID: CP019857_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_7

1646383-1646874

TypeV

I-A

Consensus_repeat	Method
GTTTTATATTAACTATATGGAATGTAAAT	PILER-CR
GTTTTATATTAACTATATGGAATGTAAAT	CRISPRCasFinder
GTTTTATATTAACTATATGGAATGTAAAT	CRT

7 spacers

The CRISPR arrays of CP019857_7

>merge|CP019857|7|1646383-1646874|PILER-CR,CRISPRCasFinder,CRT
GTTTTATATTAACTATATGGAATGTAAATACGGGAAAGCTAGAGGGTGTTTGGACTTTAGAGGAAAGTTTTATATTAACTATATGGAATGTAAATCGTTCTTGGAATGATAAATATAGAATTGGTTGGATAGTTTTATATTAACTATATGGAATGTAAATTTTTAAGCTCCACCTTGTCTTAAAAGTTTAAGCAATAGTTTTATATTAACTATATGGAATGTAAATTATACTTATAGGAGTTGGAATTATAATATTAACTACAAGTTTTATATTAACTATATGGAATGTAAATATTTGATTTTAATGGTACGTTTTCGCTTTCTCTAAGGTTTTATATTAACTATATGGAATGTAAATTACAACGACTTATATTCTAAAATAAAAATGTAAACTTCGTTTTATATTAACTATATGGAATGTAAATCTATCTTTTGTTGCTTTACATAAATTTATATTACTTATGTTTTATATTAACTATACAGAATGTAAGT

>CP019857|7|5|1646383-1646807|PILER-CR
GTTTTATATTAACTATATGGAATGTAAAT	ACGGGAAAGCTAGAGGGTGTTTGGACTTTAGAGGAAA
GTTTTATATTAACTATATGGAATGTAAAT	CGTTCTTGGAATGATAAATATAGAATTGGTTGGATA
GTTTTATATTAACTATATGGAATGTAAAT	TTTTAAGCTCCACCTTGTCTTAAAAGTTTAAGCAATA
GTTTTATATTAACTATATGGAATGTAAAT	TATACTTATAGGAGTTGGAATTATAATATTAACTACAA
GTTTTATATTAACTATATGGAATGTAAAT	ATTTGATTTTAATGGTACGTTTTCGCTTTCTCTAAG
GTTTTATATTAACTATATGGAATGTAAAT	TACAACGACTTATATTCTAAAATAAAAATGTAAACTTC
GTTTTATATTAACTATATGGAATGTAAAT

>CP019857|7|7|1646383-1646874|CRISPRCasFinder
GTTTTATATTAACTATATGGAATGTAAAT	ACGGGAAAGCTAGAGGGTGTTTGGACTTTAGAGGAAA
GTTTTATATTAACTATATGGAATGTAAAT	CGTTCTTGGAATGATAAATATAGAATTGGTTGGATA
GTTTTATATTAACTATATGGAATGTAAAT	TTTTAAGCTCCACCTTGTCTTAAAAGTTTAAGCAATA
GTTTTATATTAACTATATGGAATGTAAAT	TATACTTATAGGAGTTGGAATTATAATATTAACTACAA
GTTTTATATTAACTATATGGAATGTAAAT	ATTTGATTTTAATGGTACGTTTTCGCTTTCTCTAAG
GTTTTATATTAACTATATGGAATGTAAAT	TACAACGACTTATATTCTAAAATAAAAATGTAAACTTC
GTTTTATATTAACTATATGGAATGTAAAT	CTATCTTTTGTTGCTTTACATAAATTTATATTACTTAT
GTTTTATATTAACTATACAGAATGTAAGT

>CP019857|7|4|1646383-1646874|CRT
GTTTTATATTAACTATATGGAATGTAAAT	ACGGGAAAGCTAGAGGGTGTTTGGACTTTAGAGGAAA
GTTTTATATTAACTATATGGAATGTAAAT	CGTTCTTGGAATGATAAATATAGAATTGGTTGGATA
GTTTTATATTAACTATATGGAATGTAAAT	TTTTAAGCTCCACCTTGTCTTAAAAGTTTAAGCAATA
GTTTTATATTAACTATATGGAATGTAAAT	TATACTTATAGGAGTTGGAATTATAATATTAACTACAA
GTTTTATATTAACTATATGGAATGTAAAT	ATTTGATTTTAATGGTACGTTTTCGCTTTCTCTAAG
GTTTTATATTAACTATATGGAATGTAAAT	TACAACGACTTATATTCTAAAATAAAAATGTAAACTTC
GTTTTATATTAACTATATGGAATGTAAAT	CTATCTTTTGTTGCTTTACATAAATTTATATTACTTAT
GTTTTATATTAACTATACAGAATGTAAGT

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86399.1\|1637009_1637657_-\|lactate-utilization-protein-B/C	unknown	unknown	gnl\|CDD\|376839
CP019857.1\|AXU86403.1\|1642054_1642951_-\|NADP-oxidoreductase,-coenzyme-F420-dependent	unknown	unknown	gnl\|CDD\|378484
CP019857.1\|AXU86404.1\|1643630_1645724_+\|signaling-protein	unknown	unknown	gnl\|CDD\|238923
CP019857.1\|AXU86396.1\|1634632_1635217_+\|thioredoxin	unknown	unknown	gnl\|CDD\|239264
CP019857.1\|AXU86395.1\|1632918_1634244_-\|drug/sodium-antiporter	unknown	unknown	gnl\|CDD\|240548
CP019857.1\|AXU86407.1\|1648483_1650604_-\|ferrous-ion-transport-protein	unknown	unknown	gnl\|CDD\|223447
CP019857.1\|AXU86402.1\|1641252_1642080_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
CP019857.1\|AXU86410.1\|1651796_1652765_+\|putative-membrane-protein	unknown	unknown	unknown
CP019857.1\|AXU86400.1\|1638046_1638961_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378573
CP019857.1\|AXU86408.1\|1650629_1650857_-\|ferrous-ion-transport-protein	unknown	unknown	gnl\|CDD\|377199
CP019857.1\|AXU86414.1\|1656944_1657490_+\|ruberythrin	unknown	unknown	gnl\|CDD\|153105
CP019857.1\|AXU86397.1\|1635369_1636269_+\|iron-sulfur-cluster-binding-protein	unknown	unknown	gnl\|CDD\|274004
CP019857.1\|AXU86398.1\|1636273_1636843_+\|lipoprotein	unknown	unknown	unknown
CP019857.1\|AXU86413.1\|1655807_1656722_+\|transporter	unknown	unknown	gnl\|CDD\|223769
CP019857.1\|AXU86409.1\|1651183_1651624_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|225064
CP019857.1\|AXU86401.1\|1640385_1641234_-\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|234741
CP019857.1\|AXU86406.1\|1647532_1648351_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133409
CP019857.1\|AXU86412.1\|1654510_1655392_-\|polysaccharide-deacetylase	unknown	unknown	gnl\|CDD\|200569
CP019857.1\|AXU86411.1\|1653241_1654450_+\|tyrosyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|237360
CP019857.1\|AXU86405.1\|1647041_1647314_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86399.1\|1637009_1637657_-\|lactate-utilization-protein-B/C	gnl\|CDD\|376839	pfam02589, LUD_dom, LUD domain. This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate.	3.25008e-55
CP019857.1\|AXU86403.1\|1642054_1642951_-\|NADP-oxidoreductase,-coenzyme-F420-dependent	gnl\|CDD\|378484	pfam10728, DUF2520, Domain of unknown function (DUF2520). This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.	5.88069e-41
CP019857.1\|AXU86404.1\|1643630_1645724_+\|signaling-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	8.63161e-89
CP019857.1\|AXU86396.1\|1634632_1635217_+\|thioredoxin	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.09388e-17
CP019857.1\|AXU86395.1\|1632918_1634244_-\|drug/sodium-antiporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	5.96602e-110
CP019857.1\|AXU86407.1\|1648483_1650604_-\|ferrous-ion-transport-protein	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	4.06427e-151
CP019857.1\|AXU86402.1\|1641252_1642080_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	5.69992e-171
CP019857.1\|AXU86400.1\|1638046_1638961_-\|hypothetical-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	2.79953e-33
CP019857.1\|AXU86408.1\|1650629_1650857_-\|ferrous-ion-transport-protein	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	1.57039e-13
CP019857.1\|AXU86414.1\|1656944_1657490_+\|ruberythrin	gnl\|CDD\|153105	cd01046, Rubrerythrin_like, rubrerythrin-like, diiron-binding domain. Rubrerythrin-like domain, similar to rubrerythrin, a nonheme iron binding domain found in many air-sensitive bacteria and archaea, and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system. The rubrerythrin protein has two domains, a binuclear metal center located within a four-helix bundle of the rubrerythrin domain, and a rubredoxin domain. The Rubrerythrin-like domains in this CD are singular domains (no C-terminus rubredoxin domain) and are phylogenetically distinct from rubrerythrin domains of rubrerythrin-rubredoxin proteins.	1.43332e-53
CP019857.1\|AXU86397.1\|1635369_1636269_+\|iron-sulfur-cluster-binding-protein	gnl\|CDD\|274004	TIGR02163, Ferredoxin-type_protein_NapH_homolog, ferredoxin-type protein, NapH/MauN family. Most members of this family are the NapH protein, found next to NapG,in operons that encode the periplasmic nitrate reductase. Some species with this reductase lack NapC but accomplish electron transfer to NapAB in some other manner, likely to involve NapH, NapG, and/or some other protein. A few members of this protein are designated MauN and are found in methylamine utilization operons in species that appear to lack a periplasmic nitrate reductase.	3.69407e-25
CP019857.1\|AXU86413.1\|1655807_1656722_+\|transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	5.13478e-11
CP019857.1\|AXU86409.1\|1651183_1651624_-\|acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	2.14803e-35
CP019857.1\|AXU86406.1\|1647532_1648351_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133409	cd04782, HTH_BltR, Helix-Turn-Helix DNA binding domain of the BltR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BltR (BmrR-like transporter) of Bacillus subtilis, and related proteins; N-terminal domain. Blt, like Bmr, is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. These regulators are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	3.3683e-41
CP019857.1\|AXU86412.1\|1654510_1655392_-\|polysaccharide-deacetylase	gnl\|CDD\|200569	cd10944, CE4_SmPgdA_like, Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins. This family is represented by a putative polysaccharide deacetylase PgdA from the oral pathogen Streptococcus mutans (SmPgdA) and Bacillus subtilis YheN (BsYheN), which are members of the carbohydrate esterase 4 (CE4) superfamily. SmPgdA is an extracellular metal-dependent polysaccharide deacetylase with a typical CE4 fold, with metal bound to a His-His-Asp triad. It possesses de-N-acetylase activity toward a hexamer of chitooligosaccharide N-acetylglucosamine, but not shorter chitooligosaccharides or a synthetic peptidoglycan tetrasaccharide. SmPgdA plays a role in tuning cell surface properties and in interactions with (salivary) agglutinin, an essential component of the innate immune system, most likely through deacetylation of an as-yet-unidentified polysaccharide. SmPgdA shows significant homology to the catalytic domains of peptidoglycan deacetylases from Streptococcus pneumoniae (SpPgdA) and Listeria monocytogenes (LmPgdA), both of which are involved in the bacterial defense mechanism against human mucosal lysozyme. The Bacillus subtilis genome contains six polysaccharide deacetylase gene homologs: pdaA, pdaB (previously known as ybaN), yheN, yjeA, yxkH and ylxY. The biological function of BsYheN is still unknown. This family also includes many uncharacterized polysaccharide deacetylases mainly found in bacteria.	3.30794e-75
CP019857.1\|AXU86411.1\|1653241_1654450_+\|tyrosyl-tRNA-synthetase	gnl\|CDD\|237360	PRK13354, PRK13354, tyrosyl-tRNA synthetase; Provisional.	0
CP019857.1\|AXU86401.1\|1640385_1641234_-\|pantoate--beta-alanine-ligase	gnl\|CDD\|234741	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed.	1.64756e-163

>CP019857.1|AXU86404.1|1643630_1645724_+|signaling-protein
MNKHNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPEGKVCWQVLYPEKNSTCSFCKVLELLKNDKKGVLIKWYEKCNKLNRVFENYDSLITWQDGTVVHMHQSIDIANSTSLNKPIKINEFHEISNNKEEKGVFNFSRDNFDYNSTLLYDALIRGTDEYIYICNMKTGVFRYSPSQVELFDLPGEIVKNPLVYWKKIVHPEDWNRFYKSNTEIGKNQMDYHTVEFRAKNRSGEYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKIDSLTQLLNYHEFMSVFEDKISNPMIEKLCIVLLDIDDFKNVNEMYDRDFGDNIIKTLAQSVQSILPDNAELYKLDGDEMGILVDNVEENEILTLYNQIQNMIIHLQLWRKYGLNITISAGCVIYPKHGDTVKELYKCASYSLQYAKEHGKNRLVFFSQEILKNKMYSLEMMRDLKASINDDFRGFSLRFQPQVDTESHKIIGVEVLLRWTNDKCKAISPLEFIPILEENDMINIVGAWVLRMALRTFRKWIDYYPFFKVSVNVSAVQILEDTFIEDIVKIIDDENFPYQNLVLELTESHTVQNMSILQFKFKALQDLGIYIAMDDFGTGYSSLEVLKFSPIDIVKIDRVFVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVETQEEYDLVKQIKPDYIQGYLFGKPQTATEIFDLLKLDN
>CP019857.1|AXU86403.1|1642054_1642951_-|NADP-oxidoreductase,-coenzyme-F420-dependent
MANYFLSKGYCVSGFYGRNQLSLLESTNLTKTKIYSNLKDIIYENDILFITTSDDSIEIIDKKLSKFNLKHKYICHTSGSLKSSILFCSKKAGALIYSIHPIFAFSNKNTNIKKMKDICFSIESDNEQDDLVIQNFIDDLGNQFFIRDKDTSATYHLANVLVSNLVLSLLDIGVSYFIKLGLSEEESLKAISPLVKKNIENILDNGFTKALTGPVSRGDITPIRKHLSVLDKKDEDIYKILSLNILKIIALGNDNSLKGIKNITIENAIENLISKSEKYKEIYKLLGGKNDEKYHTDF
>CP019857.1|AXU86402.1|1641252_1642080_-|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MKNTIQTFKNAKYEGKKLSMLTAYDYSIAKIMDECDINGILIGDSLGMVIKGEENTLSVTIDEIIYHTKAVKNGVKNALIVSDMPFLSYHVSIEDAVKNAGRLIKEGGAHAVKLEGGSNVIKQIESIVNAQIPVMGHLGLTPQSVNSFGGFKVQGNTSETARQLIEDAKLIEKAGAFSIVLEGVPTKIAEMVTNSISIPTIGIGAGINCDGQILVYQDMLGMFGDFVPKFVKQYANIGDIMKDSIKNYILEVNTGAFPQEKHSFSINESELEKLY
>CP019857.1|AXU86401.1|1640385_1641234_-|pantoate--beta-alanine-ligase
MLVKEIKLLRNIIKDWRKHGYSIGLVTTMGFLHEGHQSLIKKAIKENDKVVVSVFVNPTQFGPNEDFNSYPRDIDKDFKYCMDSGATVVFNPSPEEMYLKGNCTTINVSGLTDFLCGAKRPVHFGGVCLVVSKFLNIVTPDKAYFGEKDAQQLAVIKRMVKDLNIDTEIIGCPIIRENDGLAKSSRNTYLSEEERKSALILNKSLSLAKEELVKGNLNPENIKELITAKINSEHLAKIDYVEIVDSETLQPVKQIEHSILVAIAVFIGKTRLIDNFTFELNI
>CP019857.1|AXU86400.1|1638046_1638961_-|hypothetical-protein
MIDNQKYVILSLELHLFFSRIMKEHALFLEAGFTNKNYNLAMEADHYKKQFEDLLSYTVSASNGIIRPDILYSEELVTTLTSVAEQKTEEFTGIEINKNITTRELNLQSGVNPQVGQDLVNYVAQLNSDAIRLLDGLINFKERVLDGVLSCTIFTSNYPLLLEHIIHEANLYRSYVVDLENKIDIESKNAKEIELFWDHIMMEHALFMRGLLDPSEGELINTSNDFAIKFNELIEKTNEMTDSNIKNITEETLNETVEFKDFKEAGASGIEQCKIKSIILPLLADHVLREANHYIRILESYKNM
>CP019857.1|AXU86399.1|1637009_1637657_-|lactate-utilization-protein-B/C
MIRQTPLEKRYDKLGPHIVTALKKRYFDAYYCKTRNEALQQILDLIPQNHVVSWGGSETLKEMGVQTAVREKGFKVIDRDLAKTPEERTEIMRQALLCDTFLMSSNAISEDGQLFNIDGNGNRVAAMIFGPKNVIVVAGMNKIVKNIDDAIQRTRTIASPAVVQRFQDVNTPCYINGSCIDCTSPESICAYMVTTRISRPAKKIKVILVGENLGL
>CP019857.1|AXU86398.1|1636273_1636843_+|lipoprotein
MKKFIICIIMFAISVLVLAGCTNDNKIKNEVDSMFNSIKTQDADTVDKYFPKSGLGNLIYEDKEGFKMYSKNMTWEISDIKNNKDKVTVDLKINNTDMVSILKKNPPKLGEMMPNPTMKDIDSAKKKEFNITLELVKSGDNYVCKVNQESAMKLLNVITGGGIDYLADYNKDYYKQLDEEQKNYENKNS
>CP019857.1|AXU86397.1|1635369_1636269_+|iron-sulfur-cluster-binding-protein
MKLLSKVNNNIRLITQVAFTALTNGYVNGFLEGTIYGGESKKLCVPGLNCYSCPGALGACPIGSLQAVLSSREYKFSFYVVGFLMAFGAFFGRFVCGWLCPFGLVQDLLHKVPFPVKIKKVYGDKYLKYLKYIVLIMFVIILPVAIVNVAGGGNPWFCKWICPSGTLLGGIPLILGNENLRESIGFLFSWKLSILLLILLMSIITYRPFCKYICPLGAIYGFFNPISIYRFKIDKDKCTNCTACQTKCKLDIPIYKDVNSPDCIRCGECIKVCPQNAITTTFSKDKKENNICAKKYRGI
>CP019857.1|AXU86396.1|1634632_1635217_+|thioredoxin
MKRFFIVVLGCIFVLGMISGCSKKESKPVEKNKNNSEWFSNLDTEDVDGNKVTKEIFSNKELTLINVWTTWCGPCVGEMPELEALSKEYESNNSNVAIKGLVVEVDKTDMRTGLSNEEKNLVKDIMKKSDATYQQLTVSEELKKTDFKRVMEFPTTYFVDKKGNFVGEKVVGANSKEDWKKIIDERLKMVKANE
>CP019857.1|AXU86395.1|1632918_1634244_-|drug/sodium-antiporter
MENLFTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVSTLVGSDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSLIVGILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGNSKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKSTLKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLFNVVALKLAGENGLAALTIVLYAHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFAPFIVRVFVSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSRAFVFIIIGIIILPPMLNMTGLWLTVPFAEVITIFISILFIKKYKCRYKY
>CP019857.1|AXU86405.1|1647041_1647314_-|hypothetical-protein
MKIVIGATIRYLIKHKVNYCNKKSLDKLELKYGNIDREKAVKLEIFYQYLIELEYIEMSLLIRRLDTAITSLALVSIITIASYYLIRKNV
>CP019857.1|AXU86406.1|1647532_1648351_+|MerR-family-transcriptional-regulator
MEKQYFTTGEFAKLCGISKQTLIFYDKIGIFSPEYKDKNNYRYYSVYQYDTLDILQSLREIGMSLEEIKEYIQNRTPQLCVKMLKEEEKKIREKIKKLRKISSKMQNRINITVEGISKMNSEEIYISKKFEEYLVLSSDLSNMSNSDFMMELIDFTNYCKSKNLYQGYELGVIVSNENIKNGDYLSISSFYLKIDKKIKDKKLYVKPEGMYACIKHIGKYEDSYKSYEKLKKYIYENEYKIIGNSYEESILDFFCESNEDNYMTEISIQVSR
>CP019857.1|AXU86407.1|1648483_1650604_-|ferrous-ion-transport-protein
MGLTHNSTKMSSLKDMFDIDNKEDQFVIALAGNPNTGKSTVFNHLTGLRQHTGNWPGKTVATARGNFKYKNTEYALIDLPGTYSLFALSQEEIVARDFICFGNPDAVIVVCDATCLERNLNLVFQVMELTDKVILCINLIDEARKKGITIDKKLLEDSLGIPVILTAARNGSGMDELLDTLNDVSFDKYKLNNKPVRYNENIENVVKSIQPELDNIIPGINSRWLGLRLIDGDESIFESMSNYIDKDSIDAINEVKKKIPDNINKQKIRDEFTKINYDYAKKLSDECCSNVAKKSTDREEKVDKILTSKIFGLPIMLLLLGTILWITIEGANYPSTLLSNLLLGFEPSISGILNSINCPSWLNDMLVLGLYRTLAWVISVMLPPMAIFFPLFTLLEDFGYLPRVAFNLDHLFKKACAHGKQCLTMCMGFGCNAAGVIGCRIIDSPRERLIAILTNNFVPCNGRFPTLIAISTIFFSSVITNSFVSSVATALCITLLIILGVIITLLVSYTLSKTLLKGVPSTFTLELPPYRVPQIGRTLYTSIIDRTIFVLGRAVMVAIPAGVITWIFANIYIGDLSILSHVANFLDPLAKLIGLDGFILLAFILGFPANEIVVPILLMAYLATGSMIELDSFSALGQVLREHGWTYLTALNVMLFSLLHWPCATTLLTIKKETGSLKWTALGFLMPTILAFVVCFLTTTVYNLFI
>CP019857.1|AXU86408.1|1650629_1650857_-|ferrous-ion-transport-protein
MKNLNDIQVKKTVKVEDILSSGNLRERMLALGLTRGAVIDVVRKGPKNNLTVYKIRGSKIALRQEESSLILVSDI
>CP019857.1|AXU86409.1|1651183_1651624_-|acetyltransferase
MFKIKHFNDLSLDEFYEIAKSRYEVFACEQKIFSLNDYDDIDKSSYHIFLKENGLICAYARIIPKEYSSYNDVSIGRVLVLSSHRRKGLAKQMMDCAIDFIKVNLHENNITLSAQTYIKNLYLSCGFKEISEVYDEAGIEHIKMRL
>CP019857.1|AXU86410.1|1651796_1652765_+|putative-membrane-protein
MNTTKKLTEAALLSSLFIVVTIIAVSTGFGYAIYLDFIVPVFFCIICLKCDLKYTILSGITSLLIISLVLGNLGTAIWASQSVLLGIMCGYLINKPTMVMDDLVYGSVFGVIVMVFIDIYASTLIGYSFMKEFQGYSKWIYFNGYTNFIYYLMIALFPFGMVFCIYLLSLILGNKLHILDSNSLKKFLIFKNFRNLNQFLCCSKKAFYICVSYLAIFEVLKLLNVKVDSVYLKTIFISITYISVYFIIRDSCMSLQNFIIAKFRKLLYARILFLIIILLLFFIFDVTVISLIIINAFLNKKINIRLSQSNIVNKQINLLIEK
>CP019857.1|AXU86411.1|1653241_1654450_+|tyrosyl-tRNA-synthetase
MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGLDPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFTGKIGDPTGKSKARKALTTEQVLANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRYEGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIMMPLIEGLDGKEKMSKSLGNYIGIDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVNKIESQLKEGSVNPRDIKMNLAREIVTLYHGEESAKEAEERFKSVFQKGQIPEDIQTIQVKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGKKKFVKIELVK
>CP019857.1|AXU86412.1|1654510_1655392_-|polysaccharide-deacetylase
MVKKRKKKTVTLTILVVIVIGIFSMAWADMSRKKEMKETQERLKAERLEKERIEKEKNEPIIGAKKEAVKEYGYDAKIVWDKLNKYDYSNNGEKIVFLTFDDGPSTTNTPQVLDILKRHGVRGTFFIKGDSLERKGANEILKRTFDEGNAIAHHSYTHDYKKLYPNRSLNLDTFVNELNKTDEAMKKVLGKNFSSNVVRCPGGYMSWKNMEPLGNYLKEKNMASIDWNALNADAEGKKKNAQELFEHAKKSSEGKEMVVLLMHDTYGKQETVNALDQIITYFKDNGYQFKILI
>CP019857.1|AXU86413.1|1655807_1656722_+|transporter
MKKYFGEIGLIFIAIIWGSGFVATQFALDGGLTPLQIITLRFFLAAIIMNLLFFKQIRANMGKKLLKAGGILGIFLFLAFTVQTIGLMYTTPSKNAFITAANVVIVPFIGFILYRRKLDKIGIISSLVALIGIGILSLEADFSINFGDFLTLICSFGFAFHIFFTSEFAKDNNPMALTAIQFTVAFLMSVVVQTFAGQLKMEAELSGYMGTMYLAVFSTTIGFLFQTICQKRVDGTRTAIILSTEAVFGTIFSIIILKELITAKLVIGSILIFVAIITAETKLSFLKSKKVKLKDSEESSLESI
>CP019857.1|AXU86414.1|1656944_1657490_+|ruberythrin
MKKFVCTVCGYIHEGDAAPAQCPVCKVGADKFEEMKGEMVWADEHRIGVAQGVDAEIIEGLRANFTGECTEVGMYLAMSRQADREGYPEVAEAYKRIAFEEAEHAAKFAELLGEVVVADTKENLRVRVDAEYGATDGKLKLAKRAKELGLDAIHDTVHEMCKDEARHGKAFLGLLNRHFGK

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Crispr_ID: CP019857_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_8

1848004-1849414

Orphan

I-A

Consensus_repeat	Method
GTTTTATATTAACTAAGTGGTATGTAAAT	PILER-CR
GTTTTATATTAACTAAGTGGTATGTAAAT	CRISPRCasFinder
GTTTTATATTAACTAAGTGGTATGTAAAT	CRT

21 spacers

The CRISPR arrays of CP019857_8

>merge|CP019857|8|1848004-1849414|PILER-CR,CRISPRCasFinder,CRT
GTTTTATATTAACTAAGTGGTATGTAAATCAAAGAAGCTCCACCCCATCTGTTTTTTATTATAGCGTTTTATATTAACTAAGTGGTATGTAAATTGTTTTCCATGAACATTTCGAGCTGACTTTTATTGTGTTTTATATTAACTAAGTGGTATGTAAATAACTTCTTGTTTTTTCTTTAAAACACGTACTTGGTCGTTTTATATTAACTAAGTGGTATGTAAATAAATCAATGCCAACTATAGGAACGTCGGGATTAATTGGTTTTATATTAACTAAGTGGTATGTAAATGGAGTATAAGGTAAATCGTAAGCAACTCCAGAAAGAGGTTTTATATTAACTAAGTGGTATGTAAATGAATTACAATATTATCTCCAGCATCAAGACTAGGATGTTTTATATTAACTAAGTGGTATGTAAATCTGATAGAAAAAGAAGATTATTTGAAAGTTGAGACTAGTTTTATATTAACTAAGTGGTATGTAAATAAAGATTGCAATAGATTTCCTGTTAAAATAGGTACAGGTTTTATATTAACTAAGTGGTATGTAAATACTGAACCTACTAGCATTGTAGGGTTGAAGTCTACAAGTTTTATATTAACTAAGTGGTATGTAAATTCTTTTTCAAATTGCATAGTTGGTTATACTTATTATAAGTTTTATATTAACTAAGTGGTATGTAAATAAATATGTAAGTTTTAATTTAAAATGATATTCAACTGTTTTATATTAACTAAGTGGTATGTAAATAATATTTAGAGATGGCGTAGAGTGTTAAAAGTTTCAGTTTTATATTAACTAAGTGGTATGTAAATGAAATAATAAATAGCATTGTCGAATGGTTTGCAAGCCGTTTTATATTAACTAAGTGGTATGTAAATTATAGCTAATTATTAGATTCAATTTTAATTTCGTTAAGTTTTATATTAACTAAGTGGTATGTAAATATTGCAACACTTCATCAGTTGATAAATATAGTATATTGTTTTATATTAACTAAGTGGTATGTAAATTTATACATATTTGTAGCTCCTTGCTGAACTGTTGCAGTTTTATATTAACTAAGTGGTATGTAAATTGGTTAAATCTCCAACAGAACATTTATCTAAATTACAAGTTTTATATTAACTAAGTGGTATGTAAATCTTGTTAATGCAAATAAACAACATAGCACTATTAATAGTTTTATATTAACTATGCGGTATGTAAATAGGGTTTCTGATAAAATCTTCAAACATGTAAAATATGTGTTTTATATTAACTATGAGGTATGTAAATCTTATACTTAGTTAGAACTATATATCGACACAAATATGCTTTATATTAACTATATGGTATATAAATTGCAATTTTTATTCGTTGTCCAATCTCTTTGAAATTTGTTTTATATTAACTAAGTGGTATGTAAAT

>CP019857|8|6|1848004-1849082|PILER-CR
GTTTTATATTAACTAAGTGGTATGTAAAT	CAAAGAAGCTCCACCCCATCTGTTTTTTATTATAGC
GTTTTATATTAACTAAGTGGTATGTAAAT	TGTTTTCCATGAACATTTCGAGCTGACTTTTATTGT
GTTTTATATTAACTAAGTGGTATGTAAAT	AACTTCTTGTTTTTTCTTTAAAACACGTACTTGGTC
GTTTTATATTAACTAAGTGGTATGTAAAT	AAATCAATGCCAACTATAGGAACGTCGGGATTAATTG
GTTTTATATTAACTAAGTGGTATGTAAAT	GGAGTATAAGGTAAATCGTAAGCAACTCCAGAAAGAG
GTTTTATATTAACTAAGTGGTATGTAAAT	GAATTACAATATTATCTCCAGCATCAAGACTAGGAT
GTTTTATATTAACTAAGTGGTATGTAAAT	CTGATAGAAAAAGAAGATTATTTGAAAGTTGAGACTA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAGATTGCAATAGATTTCCTGTTAAAATAGGTACAG
GTTTTATATTAACTAAGTGGTATGTAAAT	ACTGAACCTACTAGCATTGTAGGGTTGAAGTCTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	TCTTTTTCAAATTGCATAGTTGGTTATACTTATTATAA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAATATGTAAGTTTTAATTTAAAATGATATTCAACT
GTTTTATATTAACTAAGTGGTATGTAAAT	AATATTTAGAGATGGCGTAGAGTGTTAAAAGTTTCA
GTTTTATATTAACTAAGTGGTATGTAAAT	GAAATAATAAATAGCATTGTCGAATGGTTTGCAAGCC
GTTTTATATTAACTAAGTGGTATGTAAAT	TATAGCTAATTATTAGATTCAATTTTAATTTCGTTAA
GTTTTATATTAACTAAGTGGTATGTAAAT	ATTGCAACACTTCATCAGTTGATAAATATAGTATATT
GTTTTATATTAACTAAGTGGTATGTAAAT	TTATACATATTTGTAGCTCCTTGCTGAACTGTTGCA
GTTTTATATTAACTAAGTGGTATGTAAAT

>CP019857|8|8|1848004-1849414|CRISPRCasFinder
GTTTTATATTAACTAAGTGGTATGTAAAT	CAAAGAAGCTCCACCCCATCTGTTTTTTATTATAGC
GTTTTATATTAACTAAGTGGTATGTAAAT	TGTTTTCCATGAACATTTCGAGCTGACTTTTATTGT
GTTTTATATTAACTAAGTGGTATGTAAAT	AACTTCTTGTTTTTTCTTTAAAACACGTACTTGGTC
GTTTTATATTAACTAAGTGGTATGTAAAT	AAATCAATGCCAACTATAGGAACGTCGGGATTAATTG
GTTTTATATTAACTAAGTGGTATGTAAAT	GGAGTATAAGGTAAATCGTAAGCAACTCCAGAAAGAG
GTTTTATATTAACTAAGTGGTATGTAAAT	GAATTACAATATTATCTCCAGCATCAAGACTAGGAT
GTTTTATATTAACTAAGTGGTATGTAAAT	CTGATAGAAAAAGAAGATTATTTGAAAGTTGAGACTA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAGATTGCAATAGATTTCCTGTTAAAATAGGTACAG
GTTTTATATTAACTAAGTGGTATGTAAAT	ACTGAACCTACTAGCATTGTAGGGTTGAAGTCTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	TCTTTTTCAAATTGCATAGTTGGTTATACTTATTATAA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAATATGTAAGTTTTAATTTAAAATGATATTCAACT
GTTTTATATTAACTAAGTGGTATGTAAAT	AATATTTAGAGATGGCGTAGAGTGTTAAAAGTTTCA
GTTTTATATTAACTAAGTGGTATGTAAAT	GAAATAATAAATAGCATTGTCGAATGGTTTGCAAGCC
GTTTTATATTAACTAAGTGGTATGTAAAT	TATAGCTAATTATTAGATTCAATTTTAATTTCGTTAA
GTTTTATATTAACTAAGTGGTATGTAAAT	ATTGCAACACTTCATCAGTTGATAAATATAGTATATT
GTTTTATATTAACTAAGTGGTATGTAAAT	TTATACATATTTGTAGCTCCTTGCTGAACTGTTGCA
GTTTTATATTAACTAAGTGGTATGTAAAT	TGGTTAAATCTCCAACAGAACATTTATCTAAATTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	CTTGTTAATGCAAATAAACAACATAGCACTATTAATA
GTTTTATATTAACTATGCGGTATGTAAAT	AGGGTTTCTGATAAAATCTTCAAACATGTAAAATATGT
GTTTTATATTAACTATGAGGTATGTAAAT	CTTATACTTAGTTAGAACTATATATCGACACAAATAT
GCTTTATATTAACTATATGGTATATAAAT	TGCAATTTTTATTCGTTGTCCAATCTCTTTGAAATTT
GTTTTATATTAACTAAGTGGTATGTAAAT

>CP019857|8|5|1848004-1849414|CRT
GTTTTATATTAACTAAGTGGTATGTAAAT	CAAAGAAGCTCCACCCCATCTGTTTTTTATTATAGC
GTTTTATATTAACTAAGTGGTATGTAAAT	TGTTTTCCATGAACATTTCGAGCTGACTTTTATTGT
GTTTTATATTAACTAAGTGGTATGTAAAT	AACTTCTTGTTTTTTCTTTAAAACACGTACTTGGTC
GTTTTATATTAACTAAGTGGTATGTAAAT	AAATCAATGCCAACTATAGGAACGTCGGGATTAATTG
GTTTTATATTAACTAAGTGGTATGTAAAT	GGAGTATAAGGTAAATCGTAAGCAACTCCAGAAAGAG
GTTTTATATTAACTAAGTGGTATGTAAAT	GAATTACAATATTATCTCCAGCATCAAGACTAGGAT
GTTTTATATTAACTAAGTGGTATGTAAAT	CTGATAGAAAAAGAAGATTATTTGAAAGTTGAGACTA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAAGATTGCAATAGATTTCCTGTTAAAATAGGTACAG
GTTTTATATTAACTAAGTGGTATGTAAAT	ACTGAACCTACTAGCATTGTAGGGTTGAAGTCTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	TCTTTTTCAAATTGCATAGTTGGTTATACTTATTATAA
GTTTTATATTAACTAAGTGGTATGTAAAT	AAATATGTAAGTTTTAATTTAAAATGATATTCAACT
GTTTTATATTAACTAAGTGGTATGTAAAT	AATATTTAGAGATGGCGTAGAGTGTTAAAAGTTTCA
GTTTTATATTAACTAAGTGGTATGTAAAT	GAAATAATAAATAGCATTGTCGAATGGTTTGCAAGCC
GTTTTATATTAACTAAGTGGTATGTAAAT	TATAGCTAATTATTAGATTCAATTTTAATTTCGTTAA
GTTTTATATTAACTAAGTGGTATGTAAAT	ATTGCAACACTTCATCAGTTGATAAATATAGTATATT
GTTTTATATTAACTAAGTGGTATGTAAAT	TTATACATATTTGTAGCTCCTTGCTGAACTGTTGCA
GTTTTATATTAACTAAGTGGTATGTAAAT	TGGTTAAATCTCCAACAGAACATTTATCTAAATTACAA
GTTTTATATTAACTAAGTGGTATGTAAAT	CTTGTTAATGCAAATAAACAACATAGCACTATTAATA
GTTTTATATTAACTATGCGGTATGTAAAT	AGGGTTTCTGATAAAATCTTCAAACATGTAAAATATGT
GTTTTATATTAACTATGAGGTATGTAAAT	CTTATACTTAGTTAGAACTATATATCGACACAAATAT
GCTTTATATTAACTATATGGTATATAAAT	TGCAATTTTTATTCGTTGTCCAATCTCTTTGAAATTT
GTTTTATATTAACTAAGTGGTATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU86590.1\|1856500_1856677_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86589.1\|1854813_1855398_+\|sugar-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
CP019857.1\|AXU86593.1\|1859180_1859954_+\|ABC-transporter-permease	unknown	unknown	unknown
CP019857.1\|AXU86580.1\|1840840_1842298_+\|glycine-dehydrogenase-subunit-2	unknown	unknown	gnl\|CDD\|235292
CP019857.1\|AXU86582.1\|1845184_1845502_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377724
CP019857.1\|AXU86588.1\|1852647_1854492_+\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176521
CP019857.1\|AXU86583.1\|1846085_1847357_-\|guanine-deaminase	unknown	unknown	gnl\|CDD\|238628
CP019857.1\|AXU86592.1\|1858287_1859175_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213231
CP019857.1\|AXU86578.1\|1837045_1837561_+\|CF-9-family-membrane-protein	unknown	unknown	gnl\|CDD\|379370
CP019857.1\|AXU86576.1\|1833320_1834307_-\|lipoate-protein-ligase	unknown	unknown	gnl\|CDD\|161920
CP019857.1\|AXU86575.1\|1832213_1833011_-\|lipoprotein	unknown	unknown	gnl\|CDD\|224381
CP019857.1\|AXU86587.1\|1851390_1852353_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|107204
CP019857.1\|AXU86591.1\|1857251_1858274_+\|ABC-type-transport-system-involved-in-multi-copper-enzyme-maturation,-permease-component	unknown	unknown	unknown
CP019857.1\|AXU86585.1\|1850134_1850233_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86574.1\|1831511_1832111_-\|tellurium-resistance-protein	unknown	unknown	gnl\|CDD\|226595
CP019857.1\|AXU86584.1\|1849822_1850110_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU86586.1\|1850648_1851200_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|380339
CP019857.1\|AXU86579.1\|1838366_1840841_+\|bifunctional-glycine-dehydrogenase/aminomethyl-transferase-protein	unknown	unknown	gnl\|CDD\|234769
CP019857.1\|AXU86581.1\|1842741_1845099_+\|cation-transporting-ATPase	unknown	unknown	gnl\|CDD\|319795
CP019857.1\|AXU86577.1\|1834790_1836521_+\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|224671

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU86589.1\|1854813_1855398_+\|sugar-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	6.50127e-94
CP019857.1\|AXU86580.1\|1840840_1842298_+\|glycine-dehydrogenase-subunit-2	gnl\|CDD\|235292	PRK04366, PRK04366, aminomethyl-transferring glycine dehydrogenase subunit GcvPB.	0
CP019857.1\|AXU86582.1\|1845184_1845502_-\|hypothetical-protein	gnl\|CDD\|377724	pfam06865, DUF1255, Protein of unknown function (DUF1255). This family consists of several conserved hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.	2.92347e-53
CP019857.1\|AXU86588.1\|1852647_1854492_+\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176521	cd08579, GDPD_memb_like, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized bacterial glycerophosphodiester phosphodiesterases. In addition to a C-terminal GDPD domain, most members in this family have an N-terminus that functions as a membrane anchor.	1.8838e-92
CP019857.1\|AXU86583.1\|1846085_1847357_-\|guanine-deaminase	gnl\|CDD\|238628	cd01303, GDEase, Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and therefore can play a role in the regulation of cellular GTP and the guanylate nucleotide pool.	4.70771e-169
CP019857.1\|AXU86592.1\|1858287_1859175_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	7.9427e-106
CP019857.1\|AXU86578.1\|1837045_1837561_+\|CF-9-family-membrane-protein	gnl\|CDD\|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	1.12252e-21
CP019857.1\|AXU86576.1\|1833320_1834307_-\|lipoate-protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	4.63204e-94
CP019857.1\|AXU86575.1\|1832213_1833011_-\|lipoprotein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	3.07907e-94
CP019857.1\|AXU86587.1\|1851390_1852353_+\|cysteine-synthase-A	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	5.91045e-107
CP019857.1\|AXU86574.1\|1831511_1832111_-\|tellurium-resistance-protein	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	2.68958e-79
CP019857.1\|AXU86586.1\|1850648_1851200_-\|transcriptional-regulator	gnl\|CDD\|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.10679e-17
CP019857.1\|AXU86579.1\|1838366_1840841_+\|bifunctional-glycine-dehydrogenase/aminomethyl-transferase-protein	gnl\|CDD\|234769	PRK00451, PRK00451, aminomethyl-transferring glycine dehydrogenase subunit GcvPA.	0
CP019857.1\|AXU86581.1\|1842741_1845099_+\|cation-transporting-ATPase	gnl\|CDD\|319795	cd02609, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7. This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	0
CP019857.1\|AXU86577.1\|1834790_1836521_+\|Na+/H+-antiporter	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	2.00354e-58

>CP019857.1|AXU86583.1|1846085_1847357_-|guanine-deaminase
MLKVLKGNIIFTKTSETFTVFENSYIILEKGKVKGIFKEIPKEYKNLKVVDYTDKLIIPGMNDLHAHASQFKNLGMAMDKELLPWLETYTFPEESNYKDIEYATKMYKKFVKELWKSGTTRIAVFATVHKEASMKLMDIFKEVGLGAYVGKVNMNMNCPDTLLENTQDSITDTEEIINKYSDTDSIVKPIITPRFIPSCTSELLKGLGDLCLKYNIPIQSHLSENYDEIEWVRSLEPESKFYGDAYNRYNLFGQTPTLMAHCVHCSQDEIDLMRENNVMAVHCPASNFNVGSGAMPIRKLIDNNIRLALGSDISGGHTLSIFKAMVSAIQLSKLYWVNSGKKYNFLSLSEAFYIATKSGGSFFGKVGSFEEGYDFDALIIDDSNLNHDNYSILERLERFIYVGDDRNIIHRYVCGKLIEEPNI
>CP019857.1|AXU86582.1|1845184_1845502_-|hypothetical-protein
MSEFKNVTAVKKANVYFDGKVSSRVIILPNGERKTLGLMLPGEYTFSTREEEIMEMLAGSMDVKLPGSNEFVTYKEGQKFNVPSDSSFDLKVNEVVDYCCSYIAD
>CP019857.1|AXU86581.1|1842741_1845099_+|cation-transporting-ATPase
MDKVNLERYSCDINVGLNKNQLQSRIDDNLINAFDNGKTKTYKQIFKDNIFTLFNLINIVLVCLLVSVGSFKNTLFIFIAVINTIIGVIQEIRAKRLLDNLSVIVSNKVSVIREKEKKEIDVQELVLDDIMILKTGNQICADSKVLNGKLEVNESLVTGESDIIIKNKGDFLYSGSFVVSGEAFVRVENIGKDNYANKIANDAKISKKHNSQLRNSLNAILKIVGIIIIPLGIILFAKQHFGNGDSIATSVVGTVAAVNGMIPEGLTLLTSIALAVGTIKLASHKTLVQELYCVETLARVDTLCLDKTGTITEGKMQVDDIVMLEEVDINEIMGNICNSLKDDNATLNAIRDKYNVLDTYKAKNLIPFSSERKYSGVTFENKGTYLLGAFEFIFKEKNKKLRIEVERYSKKGNRVIVLAHSDSYMEDNNIPEDIKPLAFILILDKIRDEAKETLEFFYNEGVDIKIISGDNPITVSEVARKAGLKTASNFIDATTLKNDSDIYKAVDKYSVFGRVSPQQKKQMILALKKQNHTVAMTGDGVNDVLALKEADCSIAMASGSDVTKNVSNLVLLDSNFASMPKVVMEGRKVINNIQRASSLFLVKTIFSFFLSLLTLFFFSRQYPFVPIQLSLIGAVTVGIPSFFLALEANKSRISGNFLLNILKNALPGALCVTVNVIIVYNIVEYLGYSSSVFSTMCAILTGVCGLLILRQQCLPFNKERLFLIVSMTIAFVIGILFLGGLFSFVALSRELILITMVLAILMPIMIKVMLFVLDEILETIVPDLN
>CP019857.1|AXU86580.1|1840840_1842298_+|glycine-dehydrogenase-subunit-2
MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDPDMARQSELNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCTMKYNPKINEDMAALPNFTGMHPYQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDHKRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINALKEVLNDEVAALMLTNPSTLGLFEKNIKEIATLVHEAGGLLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSIGKIKNFYGNFGVLVRAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEANIKTIDIAKRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEAKEEPELLKTAPHNTLVKRVDDARAVKKPILTWSQR
>CP019857.1|AXU86579.1|1838366_1840841_+|bifunctional-glycine-dehydrogenase/aminomethyl-transferase-protein
MNELKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKINDIIYTPMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQKITDIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGEDICPAGLGCRDTLRFEAALPLYGHEINEHISPIEGGLSIFVKTNKESFIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGCASPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKKDNIILNKENKFSYIPATSEDKSKMLKVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENLSLEDLTCFLGAGAYDHYIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRKSKIVVSKTIHPETLSVLRTYLQYKDCEIVEIDFCNEYGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIMSVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGKYKPIFKGKFFKEFAVQGNLNIETINDKLLEENILGGYNLEYNYPELKNSTLLCVTEKRSKEEIDKLVGIMEGL
>CP019857.1|AXU86578.1|1837045_1837561_+|CF-9-family-membrane-protein
MEKYIWLFPLLFIFHDMEEIIGFGIWLKKNKSMLDKKYPFISKVYKNYSTEGMAFAVFEEFILCIIFCILTVITENQYVYLLWLGSFIAYTLHLVIHIGQSIIIRKYIPSLITSIICLPISIWCISKSIYIVDCEMSTTILYSIIGIIIVALNLKFAQSLIGKFTKWMSNI
>CP019857.1|AXU86577.1|1834790_1836521_+|Na+/H+-antiporter
MRNKKINIIFLTTIMFIMSTVMVFAEEDIDTIALANAEKFGILTLIPPLVAIILAFITKNVIISLLIGILSGSFIIKASGINVFATFIQAFLDLVDRALVSLADPWNAGIILQVLAIGGVINLVAKMGGAKAIAEALAKRAKSAKGTQLITWFLGLLVFFDDYANSLIVGPMMRPVADKMKISREKLAFIIDATAAPVAGLAIISTWIGLEVGLIHDAFESISIDVDAFGIFLNTIPFRFYNILILAFIVISALLLKEFGPMRKAEIKSRSRKISIDLDEGVEELDDLAPKNGVKLSVWNAIIPIGTLIIVALASFYYSGYTSIMGGDDKALIQLFTNSPYSFEAIKEAFSASDASRALFQSALVASLVAIIMAVVKKIFTISEAIDVWIDGMKSLVITGVILILAWSLSSVIKELGTAKFLIHLLSGSLPPFLLPSLIFGLGAIISFATGTAYGTMGILMPLAIPLAYSLNPDMSYVIVSTSAVLTGAIFGDHCSPISDTTILSSMGAGCNHIDHVNTQMPYAIFTAVITIVFGYIPAGLGLPIYIVLPVAIAAIFVGIQIIGKKVDEAEIELVE
>CP019857.1|AXU86576.1|1833320_1834307_-|lipoate-protein-ligase
MLLIYNEKTNPYFNLAMEEYLLKNFDEDLFILWRNEPSIIVGKNQNTLSEINLEYIKEYSIPVVRRQSGGGAVFHDLGNINFTFIACNNNNFSDFRRFTQPIIDLLKTLDVNAEFSGRNDLLIDGKKFSGNAQYNYKNKVMHHGTLLFSSEINDLSKALKVKPIKFEGKGIKSVKSRVTNISEHLHSKMDILEFKDAIMDYLSKTNTDNTNYCLSEHDIKQIEKLTKSKYETWDWNFGNSPKYTLSNELKYSGGNVEFNLNVDKGIITSIKFFGDFFGKCDVAFVENKLIGIRHEENALRNTLDSIEINDYFLGADTDILVSGILGVK
>CP019857.1|AXU86575.1|1832213_1833011_-|lipoprotein
MKFKKLLCLLLCLVLTLAVVGCSKAKDDKKIVVGATLVPGGELLEELKPLIKEKGYTLEVKNFDDYILPNEALNNGEIDANLFQHEPYLKEAVKAKGYKIMAGKKLYVCPAILYSYKIKSVDEFKKGDTIAISNNPSSCSKNLRYLESIGLLTLPKGDGLVSPKDIIENPKGIQFKELDIAQIPSSLPDVTAAFIDTTYAVPAGLDAKKNGIYTAPINDEYANLLAFRTEDKDSEKIKVLQDVLTSDKARSLIEEKYKGIVIPTF
>CP019857.1|AXU86574.1|1831511_1832111_-|tellurium-resistance-protein
MAIELKKGQKINLTKKENSNLGEILVNLNWNQKVQKKGFFGSLRSSNIDLDLGCLFEMKNGVKGAVQALGNAFGSLDNPPFAQLDGDDRTGSNTQGENLRINGNKIKDIKRILIYAFIYEGVANWSEADGIVTIKQKQDSDLVVKLDEHKNGYNMCSIALIENVNDETFSVEKVVKYFKGHREMDTEFHWGLKWVAGRK
>CP019857.1|AXU86584.1|1849822_1850110_+|hypothetical-protein
MKKILYALYSFIVIIANFRLKEKNYNFILLAIFFILLLIQNGVLKTGYQNRATFYQDNYFNGEDKNDKIKFMTIKIFIFLSLPLCFNILFNYLTS
>CP019857.1|AXU86585.1|1850134_1850233_+|hypothetical-protein
MIKVSLCVICSKYKVHIVIKQKFHINEEKNIK
>CP019857.1|AXU86586.1|1850648_1851200_-|transcriptional-regulator
MSINTVIAKNLNRLRNERNLSLGQLAELSGVSKVMLSQIEKGDSNPTVNTIWKIASGLNVPYTAILEQPQNETFIVSKTDIDVQVSENKDYRLYCYYPNTPTRNFELFQMELEEGHSYTSVGHSEKSQEYIMIIEGQLKLEVNDSIYQLRENDSICFSAESIHTYHNQGEKTLKAVIINYYPV
>CP019857.1|AXU86587.1|1851390_1852353_+|cysteine-synthase-A
MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFSKKDRVALQMITEAENAGLLVPGQAVVELTSGNTGTGLAIACACKGYKFIACMSKGNSMERARMMKALGAEVVLVDQMPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEACNHAHEKYTAEEMWEQLDGNIDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETAAIYSGKEITDQGHKIQGGGYSMDLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFAGFSSGANVCAAIKLLKSSEKGKNIILTLNDSGLKYLSTDLYEEL
>CP019857.1|AXU86588.1|1852647_1854492_+|glycerophosphoryl-diester-phosphodiesterase
MQKRILRNFIFTGKNILNKLVFIIKYNFSTLILFELFHKGLALFFIWPSIRYIFDILIKSLHIVYLNMDNFIKVLTNPMSIVLIILSVIILAFYAFFEFTSVIICLNKSIKYEKIGLFELFKISFENSIKLLYPKNILLFIFVILIIPLVNTVLISGFIGKIQIPEYILDYIKSDIILNIIYMIFLLIIYISVIRWIFSIHEITLNTENFKRARKESVNLIKGKIIRTIIYSLILSLVVAIIGYAIYHSGIIFIGIWTKYCTDMEFLKNVFINRCIAFEEYFRLILSIFIFILDIGFISATYYQYKGVSISKNNIKKEKKSISKIVFNLVLILLISYIESVAFSSHINGMFNTSFSFYTTAIAHRAGAEMAPENTLAAIKEASHAKADYAEIDVQEAKDGELIVLHDSNFKRTTGVDKNVWDVNYNEVKTYDAGSFYYYGKGYYDEKFVGEKIPTLKEMIKYSKGKVKLLIEIKLNGHEKGDVVKKVVQLIKENNFENQCIVASMDKTILQKVKKLDENLLTCYFMAIAYGDFSKLNYVDMYGIESTFVNKTVVEKIHKMNKKIFVWTVNSDSLIEKMLDLNVDSIITDNPYLIESAIYWKKNGFISQVSDYLF
>CP019857.1|AXU86589.1|1854813_1855398_+|sugar-O-acetyltransferase
MTEREKMLAGELYDCGDIELLTQWHKAKDLVRDYNQTDSSDLEKKEKILNELLGGKGKNLWITAPYYVDYGNNIYFGNNCEVNMNCTFLDDNKIIIGDNALIAPNVQIYTAFHPTNAGDRFGNAKEDGSFEFCKTQTAPVTIGDNVWIGGGAIIMPGVTIGDNVVIGAGSIVTKDIPSNMIAYGNPCRIIRENK
>CP019857.1|AXU86590.1|1856500_1856677_-|hypothetical-protein
MFIGEIDKCTHILTAYISSSYDYCNFLDTQLDDFISEYGETVVETCLHQVLLLVSRYN
>CP019857.1|AXU86591.1|1857251_1858274_+|ABC-type-transport-system-involved-in-multi-copper-enzyme-maturation,-permease-component
MVNWEIKKLAKSKSMFISLGILVLILMISIFIAPVLETESYYIDKEKGRIEDTRSGIDIGNEKFQNKINVLKQFSNQTDTGEFSKKIELMSKKKLDNLSVNEYKDISFWKVFNYRVTNSLINVGMLIIISIIISNIYVDEVVTSVKDIILSSKEKKKALKSKIFVALLVPLVIYSVYLMGIFIITCMQQGVPVNGDLESFRIVDNVVALKTNLSITKYVILNIGIELLMFEGWAMIAIFGSFISKSSISSISFFIFIISITKIMSVIHILPKKLLSVVSNVNYYDLIFGFNKIIGNYLGDIMIFKVNIDIVNIAIGLLMAILIGTMSLCFLVIKSDYISR
>CP019857.1|AXU86592.1|1858287_1859175_+|ABC-transporter-ATP-binding-protein
MNKLEIENLSKIYGKKVANDKITVTLENGVYGLLGPNGAGKSTLMKQITTLIKPDEGQILYNGEDIFKMDADYRNILGYLPQEFGVYKNFTAKEFLQYIGALKGLRGKYLNSKIGELLDLVGLYDVRNKSIGKFSGGMKRRVGIAQVLLNDPKIIVLDEPTAGLDPQERARFRNLIAKMSRDKIIILSTHIISDIESVAKETIMIKDGKLLMKGTHKDILSHMENKVYNVQVKNECEVDDIQSKYKVVSIQSDINSIVLRIVSEDILSEDNIQPVQAKFEDVYMFYFDLEDAREV
>CP019857.1|AXU86593.1|1859180_1859954_+|ABC-transporter-permease
MMYLVKAEMIKILKSKSVWIIWLFLIFFGFFLIRKFDVLDTYADIFYKIEGSIPLIGLIMFIITSGNYIKEYDSNMTGLINTTKKGKKSVVLSKLVANGLILSIINISFILLVGIRGFSFFDFKNLNEPIHNLWYFGNSNLNLTVIQMYIIVILTTIFASFIFAQIGLTLSSIFKSAVIPFILGGLIMAIPYFSVGFIPDKAIKFMSVTPNWIMMSQQMVKYNVPSILIVFSIVISIILMIVLTKITYENFTSSKRF

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Crispr_ID: CP019857_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_9

2569851-2570337

TypeV-U4

Consensus_repeat	Method
TTTTACATTCCATATAGTTAATCTAAAAC	CRISPRCasFinder
TTTACATTCCATATAGTTAATCTAAAAC	CRT
GTTTTAGATTAACTATATGGAATGTAAA	PILER-CR

7 spacers

c2c9_V-U4

The CRISPR arrays of CP019857_9

>merge|CP019857|9|2569851-2570337|CRISPRCasFinder,CRT,PILER-CR
ATTTTGAATCCACATAGTTAATCTAAAACACAATTATTAATTGTTTTATTATTGAAATCACAGCAATTTACATTCCATATAGTTAATCTAAAATGTACCCTGCTAAATTTAATTTATACCGTTGTAGCCGATTTACATTCCATATAGTTAATCTAAAACAAGCATATACACATGTCAGAAGATATTTATAAAAGGATTTTACATTCCATATAGTTAATCTAAAACAAGACTTAACACAGTAACTAAACTGTACATAATTGGTTTTACATTCCATATAGTTAATCTAAAACGATATAATAATGAAACCTTTTTTTAAACTTATTTTCTTTTTTACATTCCATATAGTTAATCTAAAACGACAGCGAACAAGAGGTTTGGGAGGATGAAAAAAGTTTTTACATTCCATATAGTTAATCTAAAACAAATTTTGTAGTAAATTTCTTCATAGCGTCAAAAATTTTTACATTCCATATAGTTAATCTAAAAC

>CP019857|9|9|2569851-2570337|CRISPRCasFinder
ATTTTGAATCCACATAGTTAATCTAAAAC	ACAATTATTAATTGTTTTATTATTGAAATCACAGCA
ATTTACATTCCATATAGTTAATCTAAAAT	GTACCCTGCTAAATTTAATTTATACCGTTGTAGCCG
ATTTACATTCCATATAGTTAATCTAAAAC	AAGCATATACACATGTCAGAAGATATTTATAAAAGGA
TTTTACATTCCATATAGTTAATCTAAAAC	AAGACTTAACACAGTAACTAAACTGTACATAATTGG
TTTTACATTCCATATAGTTAATCTAAAAC	GATATAATAATGAAACCTTTTTTTAAACTTATTTTCTT
TTTTACATTCCATATAGTTAATCTAAAAC	GACAGCGAACAAGAGGTTTGGGAGGATGAAAAAAGT
TTTTACATTCCATATAGTTAATCTAAAAC	AAATTTTGTAGTAAATTTCTTCATAGCGTCAAAAAT
TTTTACATTCCATATAGTTAATCTAAAAC

>CP019857|9|6|2569852-2570337|CRT
TTTTGAATCCACATAGTTAATCTAAAAC	ACAATTATTAATTGTTTTATTATTGAAATCACAGCAA
TTTACATTCCATATAGTTAATCTAAAAT	GTACCCTGCTAAATTTAATTTATACCGTTGTAGCCGA
TTTACATTCCATATAGTTAATCTAAAAC	AAGCATATACACATGTCAGAAGATATTTATAAAAGGAT
TTTACATTCCATATAGTTAATCTAAAAC	AAGACTTAACACAGTAACTAAACTGTACATAATTGGT
TTTACATTCCATATAGTTAATCTAAAAC	GATATAATAATGAAACCTTTTTTTAAACTTATTTTCTTT
TTTACATTCCATATAGTTAATCTAAAAC	GACAGCGAACAAGAGGTTTGGGAGGATGAAAAAAGTT
TTTACATTCCATATAGTTAATCTAAAAC	AAATTTTGTAGTAAATTTCTTCATAGCGTCAAAAATT
TTTACATTCCATATAGTTAATCTAAAAC

>CP019857|9|7|2569917-2570337|PILER-CR
TTTACATTCCATATAGTTAATCTAAAAT	GTACCCTGCTAAATTTAATTTATACCGTTGTAGCCGA
TTTACATTCCATATAGTTAATCTAAAAC	AAGCATATACACATGTCAGAAGATATTTATAAAAGGAT
TTTACATTCCATATAGTTAATCTAAAAC	AAGACTTAACACAGTAACTAAACTGTACATAATTGGT
TTTACATTCCATATAGTTAATCTAAAAC	GATATAATAATGAAACCTTTTTTTAAACTTATTTTCTTT
TTTACATTCCATATAGTTAATCTAAAAC	GACAGCGAACAAGAGGTTTGGGAGGATGAAAAAAGTT
TTTACATTCCATATAGTTAATCTAAAAC	AAATTTTGTAGTAAATTTCTTCATAGCGTCAAAAATT
TTTACATTCCATATAGTTAATCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU87256.1\|2577135_2577369_-\|transposase-IS3/IS911-family-protein	unknown	unknown	gnl\|CDD\|225511
CP019857.1\|AXU87243.1\|2567568_2568033_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87246.1\|2569022_2569388_-\|phage-related-regulatory-protein	unknown	unknown	gnl\|CDD\|214989
CP019857.1\|AXU87244.1\|2568360_2568522_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87251.1\|2572505_2572760_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87250.1\|2572146_2572479_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87242.1\|2567115_2567433_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87255.1\|2575655_2576144_+\|pilin-protein	unknown	unknown	gnl\|CDD\|225076
CP019857.1\|AXU87240.1\|2566104_2566518_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87238.1\|2565294_2565669_-\|regulatory-protein	unknown	unknown	gnl\|CDD\|367747
CP019857.1\|AXU87249.1\|2571720_2571873_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87252.1\|2573191_2573485_-\|transposase-like-protein-B	c2c9_V-U4	-	gnl\|CDD\|284650
CP019857.1\|AXU87253.1\|2574181_2574373_-\|repressor	unknown	unknown	gnl\|CDD\|367747
CP019857.1\|AXU87257.1\|2577530_2577881_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372251
CP019857.1\|AXU87254.1\|2574477_2574852_-\|regulatory-protein	unknown	unknown	gnl\|CDD\|367747
CP019857.1\|AXU87248.1\|2570642_2571527_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225786
CP019857.1\|AXU87245.1\|2568573_2569026_-\|prophage-antirepressor-related-protein	unknown	unknown	unknown
CP019857.1\|AXU87247.1\|2569507_2569660_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87239.1\|2565887_2566121_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
CP019857.1\|AXU87241.1\|2566536_2566833_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU87257.1\|2577530_2577881_+\|hypothetical-protein	gnl\|CDD\|372251	pfam12676, DUF3796, Protein of unknown function (DUF3796). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	2.99688e-34
CP019857.1\|AXU87246.1\|2569022_2569388_-\|phage-related-regulatory-protein	gnl\|CDD\|214989	smart01040, Bro-N, BRO family, N-terminal domain. This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.	5.98757e-22
CP019857.1\|AXU87248.1\|2570642_2571527_-\|hypothetical-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	0.00863953
CP019857.1\|AXU87255.1\|2575655_2576144_+\|pilin-protein	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	4.78547e-13
CP019857.1\|AXU87254.1\|2574477_2574852_-\|regulatory-protein	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	2.10171e-07
CP019857.1\|AXU87256.1\|2577135_2577369_-\|transposase-IS3/IS911-family-protein	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	0.00317149
CP019857.1\|AXU87253.1\|2574181_2574373_-\|repressor	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	4.21367e-09
CP019857.1\|AXU87238.1\|2565294_2565669_-\|regulatory-protein	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	5.07494e-20
CP019857.1\|AXU87239.1\|2565887_2566121_+\|transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	1.08383e-19
CP019857.1\|AXU87252.1\|2573191_2573485_-\|transposase-like-protein-B	gnl\|CDD\|284650	pfam07282, OrfB_Zn_ribbon, Putative transposase DNA-binding domain. This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.	2.34496e-24

>CP019857.1|AXU87247.1|2569507_2569660_-|hypothetical-protein
MKNRRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDEELEQKE
>CP019857.1|AXU87246.1|2569022_2569388_-|phage-related-regulatory-protein
MKNELMMFEGKEIEVFEFEGRILFNSKDVVNCLDIKNVNENIRLMNEKQVVKLRNSDISNTDIRKLNNAGENFLTESGVYKLIFKSRKEEAERFQGWISDEVLPSIRQTGAYINNNAIPKS
>CP019857.1|AXU87245.1|2568573_2569026_-|prophage-antirepressor-related-protein
MREKASEIEKLQLVYNSTSMLKELLDDAGFDNKSKLLTAKTLYKKAGIDLPIEINEEEHYFDTKQIASKLKIYSKSNKPAQMAVCEIIKKIDLEDGEVKGVWEINGSWTGTVNKYTKSVIDKVRTWIEENNRPTKIAGEKKNYYVFYKIE
>CP019857.1|AXU87244.1|2568360_2568522_-|hypothetical-protein
MCENLLDNMYIEKRKEEYRIKLLKIRETDIDIYNKLESIVYKLSEKKLEKNNK
>CP019857.1|AXU87243.1|2567568_2568033_+|hypothetical-protein
MDFGEVKSELSDKDLKDNEEALNKYKKYYLKVYKYYSEMDSIKSIQDIEIEQSRLKGQLQKNSNPIFALYISIMAVVFSTTINLTFDLSDITNYFIRMIMTLLFIVLLIFLVNKGILPIAIPYRNNIQFYTTALDVFEDMKNKILRERKYKKRR
>CP019857.1|AXU87242.1|2567115_2567433_+|hypothetical-protein
MDFGNINLILIGIIVIIGTTIIYLIKPKTAFCSKKYFNKLESIYGNIDKKKTVKLEVLYRYVTGLEYIAIGLFTRRLDITIIAIILVAIITTALYYLIRKKYITI
>CP019857.1|AXU87241.1|2566536_2566833_+|hypothetical-protein
MYFKTYILKREVNNKQLEITRSFDLDNLICTATEILKDNEIDLIITDEVNNVVWRNEKSTPPARECLVIAIEVYWWYTSIFLLYHINYVIKKSYLNRF
>CP019857.1|AXU87240.1|2566104_2566518_+|hypothetical-protein
MKVKSKRSFIVGIIVCVLCCASLVIYCILKDKRFLISSFLLIVIAIFNFCNAFSRKGIVEELHDSTDERDLYLTMKTSHILVKIMNYTLFTFTFLFIIAYSAWKNQSLLVIAITLCVIEIFLFVAYLLINIFLEKKE
>CP019857.1|AXU87239.1|2565887_2566121_+|transcriptional-regulator
MKTKVREFRTNMGLTQQQLADLVHVSNRTIISIEKEQYSPSLMLAYRMAQVFGTTIEELCCLKENKEMEDKKHESKE
>CP019857.1|AXU87238.1|2565294_2565669_-|regulatory-protein
MKISKLPEAELKVMRYICEANKVLTSRELVAAMEEKYEWNESTTFTVLKRLERREFLSTEKIGKLTHYNILVKEKKYLRFETKEFLKNIHKNSISSLMSALHGEDDEVDEDKLSELEECFKNLK
>CP019857.1|AXU87248.1|2570642_2571527_-|hypothetical-protein
MVGAFVLPNYAIILSEMSNLWGNFIMWILVPIITIVLLIIAVSSMQYILVMIAFLLIIYSFIEKKIVMGLVSVLFFTYSIYLCATWEDKSLIADNKVETVKAQRETVEREKEMERRRIQEEVDKERYIEKHGMEISENDLKVKLEALVPQEYKGKKYELKVGKFKRYSMYFDLTVQNEKFSNSEECKKFVKEIANDLKKIKISKAYFKFHSKDDGGIYNSVYIDYFRNIQNNVDNVENLEFNEFELKTEEEEKREQEKIEQEKNSYNNYIQNRVVDPLDRIKKLKELLDSGAIT
>CP019857.1|AXU87249.1|2571720_2571873_-|hypothetical-protein
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK
>CP019857.1|AXU87250.1|2572146_2572479_-|hypothetical-protein
MNDMARDVFSVKMTPLEAQKMVEKNLEADLVSVDIYNLENNKSIIVTIFEKYYARSNSDAGLVVICENTTGKTLVKITSTGSAIGLFQIDWGTGNNLIKRVKKILIDYII
>CP019857.1|AXU87251.1|2572505_2572760_-|hypothetical-protein
MENKDIKLTICIFAFVIGIIVLFCCIGLGQFNMDCIIKQNGGSIATEQYNIYLEQSISQYRNFGSILVLLGGIGILFDKSVRKY
>CP019857.1|AXU87252.1|2573191_2573485_-|transposase-like-protein-B
MIRNRKLSRSISDVSWSEFIRQLEYKANWHGRQIVKVGKFFASSQICNKCGYKNEEVKDLNIREWIYPSCNETHDRDINASINILKEGLRLITIQNK
>CP019857.1|AXU87253.1|2574181_2574373_-|repressor
MKISKLPEAELKVMRYIWESEKVLISREITKSMEQKYEWKDTTIFTVLKRLLKKRVFRSGENR
>CP019857.1|AXU87254.1|2574477_2574852_-|regulatory-protein
MKEEILIEKLLRAELIVMEYLWKKDTLMPKKEIVKEIKQIYGWHKSTIKILLKRLVAKRYLARYIINSQSHYKIIDSKEYYTFKKKVLKSSKSIKIMRSLTTTHKNVSKEKLDLLDEYYRNLKE
>CP019857.1|AXU87255.1|2575655_2576144_+|pilin-protein
MKNKKGFTLVELLVVIAIIGILAIVALPALFKNIEKAKIAKLEADISAIKSASLSYYADESKYTEGNIIWWTKKDGKITVNSGIGDEDPLAHKIENLGMPYNGSYTLVSSNGSEEYLELNIIIDGEISKSGLDKLEEDYGSSITIPNDKNMIITFLSNKSDN
>CP019857.1|AXU87256.1|2577135_2577369_-|transposase-IS3/IS911-family-protein
MTKYDFNFKLKVAKFYLNREGRDILIVKQYGVYNHSQVERWVNILGECALKIKKIFYTIWFKLDVINYMMITKYSVQ
>CP019857.1|AXU87257.1|2577530_2577881_+|hypothetical-protein
MIQKKFFMGFCGFLGFLSLRYFSSGNVADLTYIGFFAFFSNFIIAKINGDKADERYVQDEKAAMAFTGQLAIIELFILWCITIVSRNIELMCVLLSITYAITLNVYAIKLYILEEK

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Crispr_ID: CP019857_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_10

2735581-2735738

Unclear

Consensus_repeat	Method
AGGTTTAAGATTAACTAAGTGGATTTCA	PILER-CR

2 spacers

cas3,cas5,cas7,cas6

The CRISPR arrays of CP019857_10

>merge|CP019857|10|2735581-2735738|PILER-CR
AAATCCGATTAGTTAATTTTAAACCTAATAATAAAACTTCTATTATATCTACTATATCAATATTTGAAATCCACTTAGTTAATCTTAAACATACAAAATCTCCAACTTATAATTATTTTCGCGATGTACCTGAAACCCACTTAGTTAATCTTAAACCT

>CP019857|10|8|2735581-2735738|PILER-CR
AAATCCGATTAGTTAATTTTAAACCTAA	TAATAAAACTTCTATTATATCTACTATATCAATATTTG
AAATCCACTTAGTTAATCTTAAACATAC	AAAATCTCCAACTTATAATTATTTTCGCGATGTACCTG
AAACCCACTTAGTTAATCTTAAACCT

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU87414.1\|2743775_2744543_+\|sugar-diacid-utilization-regulator	unknown	unknown	gnl\|CDD\|379258
CP019857.1\|AXU87415.1\|2744730_2746104_-\|transporter	unknown	unknown	gnl\|CDD\|129794
CP019857.1\|AXU87400.1\|2729842_2730406_-\|sigma-54-modulation-protein	unknown	unknown	gnl\|CDD\|238308
CP019857.1\|AXU87398.1\|2728037_2729381_-\|stage-IV-sporulation-protein	unknown	unknown	gnl\|CDD\|377731
CP019857.1\|AXU87399.1\|2729393_2729630_-\|sporulation-protein-YqfC	unknown	unknown	gnl\|CDD\|377934
CP019857.1\|AXU87417.1\|2748040_2749195_-\|chaperone-protein	unknown	unknown	gnl\|CDD\|236757
CP019857.1\|AXU87411.1\|2740161_2741637_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87403.1\|2731679_2731859_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
CP019857.1\|AXU87410.1\|2739128_2740142_-\|CRISPR-associated-autoregulator,-Cst2-family	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
CP019857.1\|AXU87404.1\|2732021_2732372_-\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
CP019857.1\|AXU87401.1\|2730598_2731096_-\|sensory-protein	unknown	unknown	gnl\|CDD\|320706
CP019857.1\|AXU87413.1\|2742636_2743746_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236947
CP019857.1\|AXU87408.1\|2735880_2738289_-\|ATP-dependent-helicase	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|273707
CP019857.1\|AXU87416.1\|2746139_2747075_-\|glucokinase	unknown	unknown	gnl\|CDD\|224851
CP019857.1\|AXU87412.1\|2741641_2742379_-\|CRISPR-associated-Cas-family-protein	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
CP019857.1\|AXU87402.1\|2731206_2731650_-\|tRNA-binding-protein	unknown	unknown	gnl\|CDD\|370480
CP019857.1\|AXU87406.1\|2733714_2734473_-\|16S-ribosomal-RNA-methyltransferase-RsmE	unknown	unknown	gnl\|CDD\|236959
CP019857.1\|AXU87405.1\|2732414_2733713_-\|radical-SAM-superfamily-protein	unknown	unknown	gnl\|CDD\|223694
CP019857.1\|AXU87407.1\|2734491_2735439_-\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|283886
CP019857.1\|AXU87409.1\|2738315_2739113_-\|CRISPR-associated-protein,-Cas5t-family	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU87414.1\|2743775_2744543_+\|sugar-diacid-utilization-regulator	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	3.71654e-15
CP019857.1\|AXU87415.1\|2744730_2746104_-\|transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.56544e-35
CP019857.1\|AXU87400.1\|2729842_2730406_-\|sigma-54-modulation-protein	gnl\|CDD\|238308	cd00552, RaiA, RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD).	1.43831e-27
CP019857.1\|AXU87398.1\|2728037_2729381_-\|stage-IV-sporulation-protein	gnl\|CDD\|377731	pfam06898, YqfD, Putative stage IV sporulation protein YqfD. This family consists of several putative bacterial stage IV sporulation (SpoIV) proteins. YqfD of Bacillus subtilis is known to be essential for efficient sporulation although its exact function is unknown.	1.7162e-105
CP019857.1\|AXU87399.1\|2729393_2729630_-\|sporulation-protein-YqfC	gnl\|CDD\|377934	pfam07873, YabP, YabP family. This family of proteins is involved in spore coat assembly during the process of sporulation.	1.14572e-12
CP019857.1\|AXU87417.1\|2748040_2749195_-\|chaperone-protein	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	0
CP019857.1\|AXU87416.1\|2746139_2747075_-\|glucokinase	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.61583e-66
CP019857.1\|AXU87403.1\|2731679_2731859_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	1.30053e-12
CP019857.1\|AXU87410.1\|2739128_2740142_-\|CRISPR-associated-autoregulator,-Cst2-family	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.39287e-19
CP019857.1\|AXU87404.1\|2732021_2732372_-\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.77543e-54
CP019857.1\|AXU87401.1\|2730598_2731096_-\|sensory-protein	gnl\|CDD\|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	1.41313e-43
CP019857.1\|AXU87413.1\|2742636_2743746_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	0
CP019857.1\|AXU87408.1\|2735880_2738289_-\|ATP-dependent-helicase	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	2.22644e-42
CP019857.1\|AXU87412.1\|2741641_2742379_-\|CRISPR-associated-Cas-family-protein	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	5.48382e-16
CP019857.1\|AXU87402.1\|2731206_2731650_-\|tRNA-binding-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	3.14843e-57
CP019857.1\|AXU87406.1\|2733714_2734473_-\|16S-ribosomal-RNA-methyltransferase-RsmE	gnl\|CDD\|236959	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional.	7.40285e-85
CP019857.1\|AXU87405.1\|2732414_2733713_-\|radical-SAM-superfamily-protein	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	3.32229e-179
CP019857.1\|AXU87407.1\|2734491_2735439_-\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|283886	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	5.34054e-110
CP019857.1\|AXU87409.1\|2738315_2739113_-\|CRISPR-associated-protein,-Cas5t-family	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	1.1843e-10

>CP019857.1|AXU87407.1|2734491_2735439_-|50S-ribosomal-protein-L11-methyltransferase
MNNWIEVTIKTTTEAVEPITNILYEQGAGGAVIEDPKDFLFQKKNELDWDYVEEEVFKKNEEDDVLIKTYVSEEKNVMEFVEIIKQKVLGLKDFGIDIGEGSVSLDQVNEADWANAWKAYYKPTKVGQRVVVKPTWEDYAMQEGDLIIELDPGMAFGTGTHETTSMCIRELEKYVNKDSKVFDIGCGSGILAIAAAKLGAKEVVAVDLDEVAVKVAKENVLENKVEKSVSVMHGNLTDVIKDKADVIVANIIADIIKILAKDVQNFMKEDAIFISSGIILDKVEEVKESLIENGFEIVEVQKLGEWSAIVSKLKK
>CP019857.1|AXU87406.1|2733714_2734473_-|16S-ribosomal-RNA-methyltransferase-RsmE
MDRFFVEKNNINLQDKTCTIEGEDVKHISKVLRCKLGEKLEICDKNNNEYICEIMNIDKSIVNLEILEKVDINRESELKVRLYQGLPKAPKMEMILQKLTEVGVEEIILVQTKRSVVKVDDKKEDKKFERWERIIYEAAKQSKRGKIPKLRGVLSFKEALEDMKKNNVNICPYENERTVSIKHALKKCDSNIDSVGIFIGPEGGFSEEEIEQIQKNNCNVVSLGPRILRTETASVVASTIALYELSDLGGEK
>CP019857.1|AXU87405.1|2732414_2733713_-|radical-SAM-superfamily-protein
MKKVAFYTLGCKVNQYETEAMLELFEKDGYEQVNSEEYADVYVINTCTVTHMSDRKSRQYIRRVKKKNPDAIIAVVGCYSQVSPEEILDIEEVNLVMGTNDRRKIVEEIKKINSSKKVSTVDDIMKVKAFEEIEISQTNGKTRAFMKIQDGCDRFCTYCIIPYARGRVRSRDIDSIVDEVKKLANNGYKEVVLTGIHVASYGKDLKDRDIKLLDVIKQINQIEKIERIRLSSVEPILFTDEFVNEVLKMDKVCPHYHLSLQSGCDETLKRMNRRYTTLEYKTIVDRLRSKMPDVAITTDVIVGFPGETNEEFKKTYEFLKEIELSQMHIFKYSPRKGTPAATMENQVDPQMKHFRSEQLLNLSKVNFNKFATKFIGRELDVLFEQNIEGNKYEGLTSNYIRVVVESDKNIQGQILKVKINDVKDEYVEGILL
>CP019857.1|AXU87404.1|2732021_2732372_-|histidine-triad-nucleotide-binding-protein
MDCIFCKIANGEIPSTKVYEDDRVLAFNDLNPVAPYHILVVPKKHYDSLIDIPDKEMDIVSHIHVVINKIAKEKGFDQTGFRVINNCGSDGGQEVKHLHYHILAGKKLPNYEAGQN
>CP019857.1|AXU87403.1|2731679_2731859_-|30S-ribosomal-protein-S21
MSEVRVRENETLDSALRRFKRQCAMSGIMSEVRKREHYDKPSVKRKKKAEAARRKNAKK
>CP019857.1|AXU87402.1|2731206_2731650_-|tRNA-binding-protein
MSLKQKLQEDLKSSMKNKDTVRKSVVTLIRASIKQYEVDNRVELDEDGIIDVIAKQLKQRRDALVEFEKAGREDLIKETEGEIEVLKEYLPQQLSEEELEEIVKSTISEVGATSMKDMGKIMSVIQPKVKGRADGKLINKLVKQNLQ
>CP019857.1|AXU87401.1|2730598_2731096_-|sensory-protein
MIISVKEIRNFLINIFIPLIIGYLSSILTMIISGTDISTYYLQLTKPSFAPPAFIFPIVWTILYILMGISSYLILRKGYNLPKVRDAIFYYGLQLVLNFIWSILFFGFGLRFTALIDIIIMILVSIIMISKFSKIDKRSGYINLIYLMWLVYAGFLNYFIWFINK
>CP019857.1|AXU87400.1|2729842_2730406_-|sigma-54-modulation-protein
MQIIVSGRQMKLTDGIKGYVDGKLSRLEKYLDPESEVKVTVSAKKDRQKVEVTIIPINGQIIRAEDVEDDLYAAIDIVCDKLSRQVVKYKTKVKDKVQNNKSIRFENLDFIDNSSEFDDYDYDDEEDENIVIERRKKFNVKPMSSEEAILQMELVGHNFYMFRNQDNFEINIVYKRKAGGYGLIEQD
>CP019857.1|AXU87399.1|2729393_2729630_-|sporulation-protein-YqfC
MLEISTDLQVNQPVITVTSNTFISIENYLSILEYEVDLIRIKTKVKTIKISGDKLSLKYITDSEIGIKGIIYNVEYVD
>CP019857.1|AXU87398.1|2728037_2729381_-|stage-IV-sporulation-protein
MISFIRGYYVIVVEGVRLEQFLNHLIRNGISVYNVTRIKNTKMEFHIDRQDIKEFKNVYRGSKFDIKVKQKTGVPFIIKRVYKHKGMWICALVSLFLLMSTSQFVTDVYIQSPEGIKKEALRNELYKVGVRPGVYKKSIDRKEVRDHMMSKFNDVAYLSINVKGTNIFVTVTKKAESLKSTDQSNYCNVIALKNGIIEKVIPRSGKSVIKSGDIVQKGDVLLNGANTKSIPEVWASTFYESTKKESYVDTVNKKTGEKKNIYTLSFYDKEFTMRKNIKYKDYVVENKEKKLSIGNYTFPIKIKTSTFYETKKVEVKRNKEELKKELSEKALKELEYIIPASARIIDVKHNFKVNKNMLEYLITVQTSENIAKIYPLSKSEAERFIKEESKPDEGEEEVPSNPEKRPLNDIRNEFDEDNKDNKDQNNSDENNSNQNSNNSQNNNSNNN
>CP019857.1|AXU87408.1|2735880_2738289_-|ATP-dependent-helicase
MKNIMQKEILAKSYNLRTNQQEQTLVEHIKDLFEVLESILELNLYSDKDVEILKICCALHDLGKINSIMQQKMEINNKISYSCSEEERKKLESDKKSLKKIARHNIFSGAFLKNILEKMNLSEEDKLYIYKSIMLHHGNYEDYMRLSTSKVQKEIYDYIEKGILEKEDFNLEDIEDYIKEILYVDFKFNEDVLDYDYIDKLSESMVIYSDYNNGQIEDSVLNYRKFKYILYKGMLNLIDHSASSRQKGIKFYNDFTDEEIDNMILNEIYKSQGNLEKNNIEFNTIQKRLRELSGRNVLTVAFTGSGKTAADYRKTFKRKFFLVPNKISAESFYRKNIFQNKNDLDTRSSNDYIGLLHGDINLYSENEDNGEHDFVLTLRDIDLSINFCKPCVIATVDQLLLSMFKFPGYEKIFAAVKNASITVDEVHLLEPKMFLILIYFMQFACKYLDVDFHLMTATLPKSYKEQMINKGIIFQEESNENVTDKGEIVFIESNKEEEICEGKDVKVSFIKEKEIKSIVEDALENKQKILIIKNTIDSVNRTYEFLKENLSDKYGGVDIDVLHSRFKFKDKKEKYSKILNGEGDIWISTQSVEISLDLDFNIIISDLATMDSLIQRMGRCNRNNKYEYGNFYILPSEDKIYDNKLKSTTKNILKDILKTNSIFTMGIRKTILDDYYDNSVVKKYFEENFISCDKEIKNIYGVNKEIFDGLDLIFNFEPYKNIVDSKKEAAKIFRDVDVSYKIILEEDFYKEDRELQQDSIQVSGFIFNRLYYYGLISKVEGYMVLKSSSKFEYNSTVGLILK
>CP019857.1|AXU87409.1|2738315_2739113_-|CRISPR-associated-protein,-Cas5t-family
MKVLQCKLKQPTAHYRDPKVFQNEYISTLNLPSKTTIMGMITYLCDRRLNSDIDIGIIGTHHHRELEFSRGENIDFWNEYTNMRKGKDKEKFLLQGNYYDYYKEHKAQNSILNYEVLKEVELTIFISCKDDEELEFIRKKLESPCKYANLGRKEDFVIPSEKGCFVKEVALKEVIPMNTRDAIKENIKLKNTYVRVDLRDKENVETIINQGVLIALPHKYKDLEANRDDRVYEFCHYIYVDNDGIYPKNIKVNVCIDTKEVFTWL
>CP019857.1|AXU87410.1|2739128_2740142_-|CRISPR-associated-autoregulator,-Cst2-family
MNEKRVKGVTLTILTESPVPLSYDQGYGNYTPIKKEQYREKIHAKTSIATITYDLRRMLHQEYGWNLSNIVFGKKGNIYPSIKKNVGCVDENGLETDVFGYLIPLKDKGSISKASPLRIIPFRSLNPYKGSTQLITNRGFLSSEFGRKYYDEKEENEVPRDENFPTSQALAIEETLSDYYVYTITLELDRIGVVEVEDGKLLLPEERKFMSKELREKAVKDILDAITVFTRNIKHSSVLLKPLAVMGGAFDKVVPFFWDDVDYNADSGEINLEGVIETIESYSLKESNTILAINDRLKISNKKELNKFNLSKYPVKEIKNLADRLEIGEDNMWYLKE
>CP019857.1|AXU87411.1|2740161_2741637_-|hypothetical-protein
MREIKAKFYRSGDIVRDIGIVYFYELLMDLKNELEKNDYKLKFTCELNRNYLSLESAEYIDPKYISDYILENQLFKVFKNGKKETLEKIFSNIDNLTYVNFIEELDKSSATAKQKEDIKKDFKNRRFPYVRNSGKYGLNTSLENMETNVKRIVDTVIKSNIEIDEIDKLDLTQYEEKDSVCNVCNINKTTKLDIDLRERKDSKYNFLFRGAEKSGFKRSGQVESNICFECEFFNLMCLLYINLKRPMVFAYTNDLRELAFLNHKIMLKRKMYSDKSFYKKLLHEKISSIRLYRFDIVKNKGIILKFDSIIEYKELLKKIELIDIIDNYNFSREPVNTKNLGKKMIDNGNLSNLKELLLDNISFLKQSTGTSREMDFVSSSYNIGLYIKLCWIVDGGEEYKMKNYMESNLIYSRVGKDLFNKMTDESRRKNFSMKVIQLLKSNDRTQLFQTIMHVLVSNGILIGEGFVEGLMQSSELELNTNVGLFIQEIMK
>CP019857.1|AXU87412.1|2741641_2742379_-|CRISPR-associated-Cas-family-protein
MSRISIFMESCNGKFPNENSMLSVSFIKNILNAENKDFAKNIFNYGEERKNNKQIKDINTAIYIPNLIRSKNELLVDGDIIFNISFYNYSMFSKLYNGILKVKELEYKGYRFKIKNIKIHKEHEIKENGVIFKTMSPIIVKNKEGKYLDVEDSNYIECLNYIANLTLESVRGSGLRKPLEFIPLNFKKRVLKEKIRGFKVREFYYINAYAGTFFLKGDMEDLNALYKMGIGYRRTENAGMVDILK
>CP019857.1|AXU87413.1|2742636_2743746_+|ABC-transporter-ATP-binding-protein
MSEVILKNISKLYSNGFNAVKNINIDIKDKEFIVLVGPSGCGKSTTLRMIAGLEEISEGELYIGDKLVNDIEPKDRDIAMVFQNYALYPHLSVYENMAFALKLRKLPKDEIDKKVKEAAKILDLLPLLNKKPKTLSGGQRQRVALGRAIVRNPKVFLMDEPLSNLDAKLRTAMRTEITKLHQQLGTTFIYVTHDQVEAMTMADRIVVMKDGVVQQIATPQDVYDYPANIFVAGFIGAPQMNFIDVILIEENDEIYAQNEHIKLKLNKEKHYDLIKDNYINNEVVIGIRPEDIHVEDTFIKSNPDTCFKSRIEIKELMGAETYAHLKLGENTITIRFDSKNRINVGDDLTLSVDNSRVHIFDKETTLAIR
>CP019857.1|AXU87414.1|2743775_2744543_+|sugar-diacid-utilization-regulator
MEELKDFLERQLNKKINIYPYENQKLDASSHLVTFNNAIYVIDFLDKNNLDNLKGNFYLIYQSHIDFEYLKNIFYNLFEDINIIQHNGFFIVNSKYNLDINVTTQNIIETETYQSTYIFYLGKLDSKADFDFRLQLCSDLLPHIIKDNAENKFLNLFDLIRYKTLDLINEDNILNKLIDFNKIKSIDEELLYTGIKFINNDLNISKTSTSMFLHRNTLVYRLEKINEILGFDLKNFENAMIFYLSVKSYFLYKKI
>CP019857.1|AXU87415.1|2744730_2746104_-|transporter
MGKTNARRTLFLIAIGSGTMLNPLNSSMISLALHSIQNDFHISFTTVSWIVSAFYLANAIAQPVSGKIGDLIGRKVLFLSGLMLVILSASIVPLVQSFFILIFIRVIQAIGTSTLYPSGVALIQNNIKERQSSALAVLTIFASTTAGLGPTLGGLLLDLGGWHAIFLVNIPVVLVSICLGYFLFPKEVKEKKSIKETLKNVLSRLDIIGILLFSIAMIFILLFLLSMKESFNLEQLVFGIILMCLFIWHELRTKLPFIDIKLFVSNPKLSKVYLQFIILNFFNYILFFGLPSYFQDALHYSAKSTGLFMLFMSGIGIFISPLTGKWIDKSGTRFPLVTSSIFMFISAVLLSVVFIHIPVIGKGIILSLAGISYGVGNVALQSSMFEESPRDSIGTASGLFQTSRYLGSILATVLLGMVFEVNITSEQFQILGYVMVVLGTISFLLNFILKKELRKVE
>CP019857.1|AXU87416.1|2746139_2747075_-|glucokinase
MYYIGVDIGGTGIQAGVVDNYGKIIFRSECKTVIEKGFEGILNDIKIMIYKLLEDNKLTMSDIKSIGFGVPGFINKEGLVTCVNLKWNKKAFNKELKRRFPDVEIHGENDATVAALGEAKFGSMKGANVGVLYTLGTGVGGGIVINQKVFSGAHGLGSEIGHQIIGENYFNCNCGNNGCVETFCSATAIIKYSQKLIEEGEKSRILDLAEGNLENVNAKMVFDAYRENDLVAIKVINRFKEYLAKTFANTINSLDPEIISIGGGISKSSDIILDGIEDLVRKFVLYKTEDIATITCATLGSDAGIIGAAFL
>CP019857.1|AXU87417.1|2748040_2749195_-|chaperone-protein
MSTKRDYYEVLGISKGAEAQEIKKAYRKLAMKYHPDRNPGDKEAEEKFKEINEAYEVLSDDTKRKTYDQFGHDGLNGQGGFGGQGGFGGQGFGGFEDMFGDIFGDMFGGSFGGGRARRRGPQRGADIRQSVTISFEEAAFGKKMSIKVNRSEECEECNGTGAKPGTSKKTCSTCNGTGQVRTVQRTPFGNIASSRPCSACNGTGEVIESPCSKCHGTGNTRKVKTIEVDIPAGIDDGQMIKLSGQGEVGEKGAPRGDLYIVVNVKSHPLFTRDGNDIYFEMPITFVQATLGDEIEVPTLDGKVKYSVPEGTQTGTVFRLKEKGIPRIRGNSRGDQYVKVVVEIPKKLNDKQKELLREFAKECGSNVHEKKKTFGQKIEDMFKKK

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Crispr_ID: CP019857_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_11

2817029-2817524

Orphan

I-A

Consensus_repeat	Method
GTTTTATATTAACTATATGGAATGTAAAT	PILER-CR
ATTTACATTCCATATAGTTAATATAAAAC	CRISPRCasFinder
ATTTACATTCCATATAGTTAATATAAAAC	CRT

7 spacers

The CRISPR arrays of CP019857_11

>merge|CP019857|11|2817029-2817524|PILER-CR,CRISPRCasFinder,CRT
ATTTACATTCCATATAGTTAATATAAAACTTGTGTTTATTGTGATAGTGCCGAACAGGTGTTAATACGATTTACATTCCATATAGTTAATATAAAGCTCTAATTTAATAGCTTTATTTTTAGCAAAATACCCAAATTTACATTCCATATAGTTAATATAAAACCGGTTCCCTCCGAAGTTCATAGAGATTCTTATCAGCATGATTTACATTCCATATAGTTAATATAAAACAAATGCTGAAAGATAATTCGGTTGGGGATTTAATGAAATTTACATTCCATATAGTTAATGTAAAACTAAATAGAGCAGATGAGGCTTTTCAAGAAGCCGATAGATTTACATTCCATATAGTTAATATAAAACTCTGATGTTGTGAGATTTGAAAAAAACGGTAAATTGAATTTACATTCCATATAGTTAATATAAAACGCTGATAAAGTTATTAAAAGTAAAATTGCTGAAATACTATTTACATTCCATATAGTTAATATAAAAC

>CP019857|11|9|2817029-2817524|PILER-CR
ATTTACATTCCATATAGTTAATATAAAAC	TTGTGTTTATTGTGATAGTGCCGAACAGGTGTTAATACG
ATTTACATTCCATATAGTTAATATAAAGC	TCTAATTTAATAGCTTTATTTTTAGCAAAATACCCAA
ATTTACATTCCATATAGTTAATATAAAAC	CGGTTCCCTCCGAAGTTCATAGAGATTCTTATCAGCATG
ATTTACATTCCATATAGTTAATATAAAAC	AAATGCTGAAAGATAATTCGGTTGGGGATTTAATGAA
ATTTACATTCCATATAGTTAATGTAAAAC	TAAATAGAGCAGATGAGGCTTTTCAAGAAGCCGATAG
ATTTACATTCCATATAGTTAATATAAAAC	TCTGATGTTGTGAGATTTGAAAAAAACGGTAAATTGA
ATTTACATTCCATATAGTTAATATAAAAC	GCTGATAAAGTTATTAAAAGTAAAATTGCTGAAATACT
ATTTACATTCCATATAGTTAATATAAAAC

>CP019857|11|10|2817029-2817524|CRISPRCasFinder
ATTTACATTCCATATAGTTAATATAAAAC	TTGTGTTTATTGTGATAGTGCCGAACAGGTGTTAATACG
ATTTACATTCCATATAGTTAATATAAAGC	TCTAATTTAATAGCTTTATTTTTAGCAAAATACCCAA
ATTTACATTCCATATAGTTAATATAAAAC	CGGTTCCCTCCGAAGTTCATAGAGATTCTTATCAGCATG
ATTTACATTCCATATAGTTAATATAAAAC	AAATGCTGAAAGATAATTCGGTTGGGGATTTAATGAA
ATTTACATTCCATATAGTTAATGTAAAAC	TAAATAGAGCAGATGAGGCTTTTCAAGAAGCCGATAG
ATTTACATTCCATATAGTTAATATAAAAC	TCTGATGTTGTGAGATTTGAAAAAAACGGTAAATTGA
ATTTACATTCCATATAGTTAATATAAAAC	GCTGATAAAGTTATTAAAAGTAAAATTGCTGAAATACT
ATTTACATTCCATATAGTTAATATAAAAC

>CP019857|11|7|2817029-2817524|CRT
ATTTACATTCCATATAGTTAATATAAAAC	TTGTGTTTATTGTGATAGTGCCGAACAGGTGTTAATACG
ATTTACATTCCATATAGTTAATATAAAGC	TCTAATTTAATAGCTTTATTTTTAGCAAAATACCCAA
ATTTACATTCCATATAGTTAATATAAAAC	CGGTTCCCTCCGAAGTTCATAGAGATTCTTATCAGCATG
ATTTACATTCCATATAGTTAATATAAAAC	AAATGCTGAAAGATAATTCGGTTGGGGATTTAATGAA
ATTTACATTCCATATAGTTAATGTAAAAC	TAAATAGAGCAGATGAGGCTTTTCAAGAAGCCGATAG
ATTTACATTCCATATAGTTAATATAAAAC	TCTGATGTTGTGAGATTTGAAAAAAACGGTAAATTGA
ATTTACATTCCATATAGTTAATATAAAAC	GCTGATAAAGTTATTAAAAGTAAAATTGCTGAAATACT
ATTTACATTCCATATAGTTAATATAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU87479.1\|2826248_2826821_-\|metal-dependent-phosphohydrolase	unknown	unknown	gnl\|CDD\|224627
CP019857.1\|AXU87474.1\|2817809_2817968_-\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87472.1\|2814996_2815992_+\|L-asparaginase	unknown	unknown	gnl\|CDD\|199208
CP019857.1\|AXU87476.1\|2821503_2822172_-\|vanZF-protein	unknown	unknown	gnl\|CDD\|377417
CP019857.1\|AXU87475.1\|2818326_2819697_-\|cell-surface-protein	unknown	unknown	gnl\|CDD\|380277
CP019857.1\|AXU87478.1\|2825781_2826132_-\|iojap-family-protein	unknown	unknown	gnl\|CDD\|376779
CP019857.1\|AXU87473.1\|2816465_2816564_-\|regulatory-protein	unknown	unknown	unknown
CP019857.1\|AXU87471.1\|2813247_2814876_+\|aspartate-aminotransferase	unknown	unknown	gnl\|CDD\|163513
CP019857.1\|AXU87467.1\|2809294_2810110_-\|transcriptional-antiterminator	unknown	unknown	gnl\|CDD\|170086
CP019857.1\|AXU87466.1\|2807691_2809242_-\|PTS-system-transporter-subunit-IIBC	unknown	unknown	gnl\|CDD\|273925
CP019857.1\|AXU87481.1\|2827786_2828425_+\|recombination-regulator-RecX	unknown	unknown	gnl\|CDD\|234646
CP019857.1\|AXU87469.1\|2810896_2811277_-\|translation-inhibitor-endoribonuclease	unknown	unknown	gnl\|CDD\|129116
CP019857.1\|AXU87480.1\|2826821_2827511_-\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
CP019857.1\|AXU87470.1\|2811371_2812589_-\|threonine-dehydratase-catabolic	unknown	unknown	gnl\|CDD\|236182
CP019857.1\|AXU87482.1\|2828577_2830581_+\|glycogen-branching-protein	unknown	unknown	gnl\|CDD\|215246
CP019857.1\|AXU87483.1\|2830754_2831396_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
CP019857.1\|AXU87464.1\|2805353_2806067_-\|AraC-family-transcription-regulator	unknown	unknown	gnl\|CDD\|225080
CP019857.1\|AXU87477.1\|2823007_2825428_-\|leucyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|234743
CP019857.1\|AXU87468.1\|2810130_2810613_-\|PTS-system-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376324
CP019857.1\|AXU87465.1\|2806242_2807595_-\|6-phospho-alpha-glucosidase	unknown	unknown	gnl\|CDD\|133434

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU87479.1\|2826248_2826821_-\|metal-dependent-phosphohydrolase	gnl\|CDD\|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	4.17724e-52
CP019857.1\|AXU87472.1\|2814996_2815992_+\|L-asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	8.27962e-141
CP019857.1\|AXU87476.1\|2821503_2822172_-\|vanZF-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	6.04707e-18
CP019857.1\|AXU87475.1\|2818326_2819697_-\|cell-surface-protein	gnl\|CDD\|380277	NF033435, S-layer_Clost, S-layer protein SlpA. In Clostridiodes difficile, the S-layer protein precursor, SlpA, is one member of a large paralogous family of protein that share several cell wall-binding repeats. SlpA is cleaved into a larger and smaller protein. The S-layer protein itself is important to adhesion, and portions of it are highly variable, and then N-terminal and C-terminal are well-conserved.	3.16421e-19
CP019857.1\|AXU87478.1\|2825781_2826132_-\|iojap-family-protein	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	7.43119e-49
CP019857.1\|AXU87469.1\|2810896_2811277_-\|translation-inhibitor-endoribonuclease	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	6.43782e-69
CP019857.1\|AXU87467.1\|2809294_2810110_-\|transcriptional-antiterminator	gnl\|CDD\|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	2.51602e-51
CP019857.1\|AXU87464.1\|2805353_2806067_-\|AraC-family-transcription-regulator	gnl\|CDD\|225080	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism].	5.57984e-15
CP019857.1\|AXU87481.1\|2827786_2828425_+\|recombination-regulator-RecX	gnl\|CDD\|234646	PRK00117, recX, recombination regulator RecX; Reviewed.	3.67554e-47
CP019857.1\|AXU87471.1\|2813247_2814876_+\|aspartate-aminotransferase	gnl\|CDD\|163513	TIGR03801, For_A_Pyridoxal-5-_Phosphate, aspartate 4-decarboxylase. This enzyme, aspartate 4-decarboxylase (EC 4.1.1.12), removes the side-chain carboxylate from L-aspartate, converting it to L-alanine plus carbon dioxide. It is a PLP-dependent enzyme, homologous to aspartate aminotransferase (EC 2.6.1.1). [Energy metabolism, Amino acids and amines].	0
CP019857.1\|AXU87480.1\|2826821_2827511_-\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	9.36329e-79
CP019857.1\|AXU87470.1\|2811371_2812589_-\|threonine-dehydratase-catabolic	gnl\|CDD\|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
CP019857.1\|AXU87482.1\|2828577_2830581_+\|glycogen-branching-protein	gnl\|CDD\|215246	PLN02447, PLN02447, 1,4-alpha-glucan-branching enzyme.	0
CP019857.1\|AXU87483.1\|2830754_2831396_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.10482e-19
CP019857.1\|AXU87466.1\|2807691_2809242_-\|PTS-system-transporter-subunit-IIBC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.41453e-101
CP019857.1\|AXU87477.1\|2823007_2825428_-\|leucyl-tRNA-synthetase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
CP019857.1\|AXU87468.1\|2810130_2810613_-\|PTS-system-transporter-subunit-IIA	gnl\|CDD\|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	7.48839e-57
CP019857.1\|AXU87465.1\|2806242_2807595_-\|6-phospho-alpha-glucosidase	gnl\|CDD\|133434	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases. Bacillus subtilis GlvA and Clostridium acetobutylicum pagL are 6-phospho-alpha-glucosidase, catalyzing the hydrolysis of alpha-glucopyranoside bonds to release glucose from oligosaccharides. The substrate specificities of other members of this subgroup are unknown. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP_PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases, which include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. Members of this subfamily are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0

>CP019857.1|AXU87473.1|2816465_2816564_-|regulatory-protein
MLNKKLPDAELKIMKYIWNTGYKTVISKDVAD
>CP019857.1|AXU87472.1|2814996_2815992_+|L-asparaginase
MSIKKKVAIVFTGGTISMTVDDKVGAAIPTLSGEQILSMVTNIDKVADVEVFNFDEIPGPHITPYRMMELKNYVNDLLARKDITGVVITHGTDSLEETAYFLDLTIDNIKPVIVTGAMRSSSELGYDGSSNLSASVCTAVSKDAMGKGVLVVLNNEVLLASEATKTNTLSLNTFKSLTSGPLGIIDCNELVLTRDIVNRTIIDTDKVESKVALFKAYVGENADFIRFAVDSGYKGIVIEAMGRGNIPPQMLSGVEYAREKGLPVVIVSRCHSGRVFDSYGYFGSGRDLKNLGCIFGGDLPGQKARIKLILALGKTDNLDEIKDFFEKGIYC
>CP019857.1|AXU87471.1|2813247_2814876_+|aspartate-aminotransferase
MKNHTYKEIKNIYGKISPFEFKDKLIDIAKYTAKENNRELLDAGRGNPNWTCSTAREAFFTFGHFAITETRSNWDLGHLAGMPQKKGIKERFFKFINENIDMPGAYLARDIINFGINELGFDGDEFVHELADGIIGDNYPLPDRMLPHMEKIVHDYLVQEMKYDISGKYGDVEIFAVEGATAAMCYIFDSLMANELLKKGDTIALMTPIFTPYLEIPNLPRYDFKVVNINANEVDEKGAHTWQYTKKELEKLRDKSIKALFVVNPNNPASIAMDETSCNNLIDVIENYNKDLMIISDDVYGTFVEDFSSLMSKLPYNTVGVYSYSKYFGVTGWRLGTFALHKKNVFDKKINDLTGELKKSVDKRYSDMSLNPSSLSFMERVVADSRLVALNHTAGLSTPQQVQMAFFSAFALIDKVDAYKKLNMSICHRRQKLLFEALELPINENKNNAAYYTQFDIEEWAKLNYGEGLFKFISKNASPVDVLYKLANDYSVVLLSGNGFYGPEWSIRISLANLYDEAYTKIGKAIREILNGYIVEWQKIKK
>CP019857.1|AXU87470.1|2811371_2812589_-|threonine-dehydratase-catabolic
MMNVTLTDVKEARETIKNIVKRTDLLESVKLSEKTGANVFYKCENLQKTGSFKLRGACNKIASLTDEEKANGVIASSAGNHAQGVALGAKMTGIKSTIVMPATAPLAKVSATKGYGAEVVLNGAVYDDAYAKAVEIQKETGATFLHPFNDKYVIAGQGTISLEIFEQLDNKVDTILCPVGGGGIISGVAVAAKALNPNVKIVGVQTANIPSMKESIKNGKVTTAFNDTTIADGIAVKTPGDLTFEIINELVDEIVVVEETEIAESILFMMESQKIVSEGAGAVCTAAILSGKYVPAKDENVVCIISGGNIDINTLYRIIGVALAKEGRRYSFSTIMEDKPGNFAELTRIISENGGNILSANQGKLSAGEALGKQSAEFILETIDYDHIARIKKAIEEKGFKIIEL
>CP019857.1|AXU87469.1|2810896_2811277_-|translation-inhibitor-endoribonuclease
MKHEVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIAVL
>CP019857.1|AXU87468.1|2810130_2810613_-|PTS-system-transporter-subunit-IIA
MLNFFKKNKSYKLHAVVSGNSINIEKVNDSVFSKKLMGDGVAIIPNSDVVVAPCNGKVTVLTESKHAFGMVSDEGVEILVHIGIDTVSLQGEGFKNEVSQGDTVKKGSPIISFEREKINSQGIDCTTIIIVLNHSEFSEINCMVENEVVAGQDTVIEIMK
>CP019857.1|AXU87467.1|2809294_2810110_-|transcriptional-antiterminator
MRVVKIFNNNALSTVTNDRKEAILLGLGIGFNKRPGDKVNEDKIEKIYYVQDHMQTKFLELLKNVSPEVMDASQQIISLIPGNEGKFNNKGILSLVEHISFAIDRMKNNVFLPNLMLLDIKMMYSKEFELGVKALEIIYRVCHIHLPEDEAGYIALHFVNLQSNDNLAYDTLKFVKGSIDLIKECYGLELDESSLSTLRFRTHLKFLAQRIFKNEICQDDKMIEMYDYLINNHPKNKEYLEKLNVYIEKEFRYKLDKPEKIYLLLHLTKIL
>CP019857.1|AXU87466.1|2807691_2809242_-|PTS-system-transporter-subunit-IIBC
MKEKLLGGLETFAKAMVQPLMYLSSAGILMVVGVLLTNDMLLGVLPFFKWEPIQIFGSLIYNCIMAIINNLAVIFAIGIPAALAKKEKHKAALIGFMSYIIYLTASNTMLTSLGQLAKESKMLGLIGTGQATILGIQVVDTSVFGGIILGCIAGYVFNRTSNKTFKGALQIYSGANFSFICMFFVSILIGVVSNFIWPLAQQGIASLANVIKDTGTFGLFLYGFLERILVPTGLHHLIYTPFQFSDLGGVLKVGADTVSGAYAIVMTEMNLPVERFSDSIYYMATGFTKMFGYIGIGAAFIYTAYKQNKKKVKATIIPLIITAVLASVTEPLDFMFVFCAPLLFFVHAVIAGLFIALLKIFDVTALCGGNLLVSIIMNTTVGVEKTHWPVMMILGLAQIIVYFVVFSFLIKKFNYKTPGREDESTATGEEQSKQLNLDAGIENIIDGLGGKENINTVENCITRLRVNVKDESKINEDIINLTPNSGIVRKGKDIQIIFGLHVHEVRRAVEDFLEAY
>CP019857.1|AXU87465.1|2806242_2807595_-|6-phospho-alpha-glucosidase
MIITIVGGGSTFTPGIVKSIALREKELELEEIRLFDIDKKRQDKVAVVVNWILKEDVKTDVKLTVTNCEKEAYTDATFIFAQMRVGKYEMREQDEKIPLKYGCVGQETCGCGGMAYGLRTIQPMIKVIDDVEKYAKKDYWILNYSNPAAIVSEACRKLRPNARIINICDMPIAIIDMIAGSLNINDVHNIRYDYFGLNHFGWFTSIDYKHRDLMEEIKEYIKENKILLPKSYIENLNKSRSTGNRHAVSSWIHVWESVYTMLESFPKYLPNTYLTYYLLSKETVEHSNINRTRANEVMESREKDLFEGVRHYLETGEISEKAFYAGLHGDWISDLAVSIKNDTRSRFLVITENRGAIPNMPYDAMVEIPAYIGKDGPEVIARGPIPLFQQGLMMQQLNSEKLIVEAYIENSYEKALQAFTLNKTIPSMNVAKEILDEMIEVNKEYWPELR
>CP019857.1|AXU87464.1|2805353_2806067_-|AraC-family-transcription-regulator
MITNNLEADTHSHCMLQLFLGIEDSIEITVNEKLVKCNCIIVDKNISHSFSARKKVYYSAIIEPTSIYAEQLTSKMNDFGYWICDNNGLEKLRQQGTFLIDNSSKEQYLRFMEMLNNYLNIPITLKHYDDRITELLNLLRTCNCDNHTISSFADKVSLSASRLSHLFKEQIGIPLKSYILFHQMECAFRELLSGKNVTEASMTAGFDTPSHFAGTVKRMMGMPVSLSLKDSEFLKVY
>CP019857.1|AXU87474.1|2817809_2817968_-|hypothetical-protein
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
>CP019857.1|AXU87475.1|2818326_2819697_-|cell-surface-protein
MKLKKLLSLGLAVSMFAAGPISANALDTIYTIQGKDKYETAALIADEQNYTTAILINADSTMADGLSASGLAGATNAPIFLTKKNNIPNATLKRVEKAKKVYIIGGESSIDKATETLLKDKGIEAKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAFKGEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMSDKLVNDTNSTRLGGVDRYDTNKKIVNKFYNGAKEFYIASGTDLVYALVASPMAKNNPIVLVDIGSNKDILKNAAKVTGIGNLSDKIMLECENTINNISLPSSNKNIICGLKIDFDSKHIIWQDKGSYLECYDDNLEYYTEKYKDPTVPINIENTSTQNLDVTKLKVYGEANSTLYMGQYAKIKMDFNSFGVLKPGEKCTIYLDIISLDPSRSMTLTFSYVGDKENYKYEQGLASRILFYNPDGEDFFEYK
>CP019857.1|AXU87476.1|2821503_2822172_-|vanZF-protein
METVTNNQSGVEIQLSLFEAIKDLLLINPIFLLGIILIGIFLVVIFKKNSDIPKVKTSILSLAMYYYLCLTLSHIVGIPTFGEYIRLSQLGETFFNPNINLIPFSDGFSLSFILNILLFVPLGFLCPLISKTFERLRNTFLIGFGLSLFIETIQLFTLHRATDIDDLLTNVIGTIIGYFCFKLIAKLRIVKLHSDDDSMEQDYTVCIPIAIIIVALILGFFS
>CP019857.1|AXU87477.1|2823007_2825428_-|leucyl-tRNA-synthetase
MSVYNFKEVESKWQKIWKDNNQYKMDTAQTEKPNYYTLEMFPYPSGKIHMGHVRNYSIGDVVARFKKMEGYNVLHPMGWDSFGLPAENAAIKHGIHPHKWTMENIEEMKEQLNLLGISYDWDKEVATSTPEYYRFTQEIFLKFLEHGLAYKKKSYVNWCPSCETVLANEQVVQGACERCKATVLKKDLEQWYFKTTEFAEELLNDLDTLDGWPEKVKTMQKNWIGKSTGADLVFDIDGTDKSMTVFTTRPDTTYGVTYMVLAPEHELVKELVAGTEYEADVETFVQKMHTMTEIERTAADVEKEGMFIGRYVINPLNGKKVPLWIANYVLVEYGTGAIMAVPAHDERDRDFAEKYNLDIIDVITEDNKMINSEEFNGLDASEGFEGIIDKLEKEGRGKRTINYRLRDWLVSRQRYWGCPIPVVYCDECGIVPVKKEDLPVLLPTDVEFTGKGESPLTTSKQFMSTTCPHCGKPARREVDTMDTFVDSSWYFLRYVDSNNENEPFSKELVNRWHPVDQYIGGVEHAIMHLLYARWFVKAFKSMGMVDFNEPFKNLLTQGMVLMDGSKMSKSKGNTVSPMDIIDEYGADTARLFVLFAAPPERDLDWSEQGVDGCFRFLNRVYRLVDELADVVKKDVEFGELNSQDKDMRYTIHSTLKKVTADLSEKFGFNTAISALMELINDMYKYKELDNINEAVIKEGVQTIVTIIAPFAPHLGEELWTMIGKEGSVFDIDWPKYDEKALVKDEIEVVVQVNGKVRGKLTVNSNISKDEMEKVALEDEKIKGLVEGKTIVKVVAVPKKLVNIVVK
>CP019857.1|AXU87478.1|2825781_2826132_-|iojap-family-protein
MTVEQMTKIAYDAIEDKLGQDTVIINIGKVSSLCDYFIITTASSQRQVKAIADNVEDELAKLGLEPRGKEGQGTQTWVLLDYGDIMVHVFNEENRGFYNLEKLWKDAPYIDIDTLA
>CP019857.1|AXU87479.1|2826248_2826821_-|metal-dependent-phosphohydrolase
MNLENINQRLNQMLPVGRLSHSKNVAKCAEKLCEIYGCDKEKAYLAGMIHDCAKYLSDKEIEDYVNKYEIYLDPIEDGNRSLSHSVIGAYICEYEFEVEDEDIINAIKYHTTGREDMSLLEKIIYIADLIEEGRKFPVVDTLRELAYGGKLDEALLTSFNNTLMFVINKKEEIHPRTVMARNYLIKEKLL
>CP019857.1|AXU87480.1|2826821_2827511_-|nicotinate-nucleotide-adenylyltransferase
MRSENLVKMAELKNTEKLEKFNRHKGKIKIGILGGTFDPIHYAHLATAEFIRDKYDIDKIIFIPSGNPPHKLCITTDKYDRYNMTLLATESNEDFLVSKVEIERKKRTYTIDTLKYLKKKYKNADIYFITGADAICSVEEWKDVKKNFELATFIAATRPGISLLRSQETIEKLTKKYNADIITVYVPSLDISSTYIREQLNEGKSIRYLVPENVENYLYENKLYQYGDD
>CP019857.1|AXU87481.1|2827786_2828425_+|recombination-regulator-RecX
MGIITKIEQQKRNDDRVNIYVDDKFFIAIFKELVYTFNLKKGNEINEEELKPILDDEMYIKAKNKALNILSHADQSEKKLKEKLSSEFDENIIERVIDFLKSYNLVNDSVLAQKIVNTNVNLNKCGKNRIKQNLYNKGINRSTINEAVSELDKDTEFENAMYLAKKRYERVKKEDKKKIYQKISQHLSYKGFDYDIIKRVLNKLLNFDEYDI
>CP019857.1|AXU87482.1|2828577_2830581_+|glycogen-branching-protein
MKSQKRFKILDIDVYLQPFESDIKKRMKHYEDMKSKTLKNYKDFSSFANAHLYYGFHQTNDGFFYREWAPNADSLSLIGDFNNWNRKSHPLRKIGSGNWEIFIPGQNSLPHKSEVKVQVTANGKTFDRIPLYIKRVIQKDFGGFNGQIWQPKTPFIWTDNNFDLKNITSPLIYECHIGMSTESESIGTYNEFTEKILPKIKKAGYNTIQLMAIMEHPYYASFGYQVSNFYAISSRFGTPEDLKNLINTAHSMGIAVLLDLVHSHAVKNTLEGINEFDGSEHQFFHSGSKGNHPAWGTKLFNYGKPEVIHFLLSNIKFWLNEYHFDGFRFDGVTSMLYHNHGLGVSFDSYEKYFSMNTDIEAITYLQFANELIKEIKPNSISIAEDMSGMPGMCIPIKDGGIGFDYRLAMGVPDFWIKTISNLSDEDWDLGKMWYELTTRRPGEKNIGYCESHDQALVGDKTIIFWLADKEMYWNMEINSNNHVINRAISLIKLIKLITFSLAGEGYLNFMGNEFGHPEWIDFPREGNNWSYKYARRQWSLSEDNNLKYKQLLNFDKSMLELTKYSDIFIQNSHELIHMDNDKKILVYSKGKYLFIFNFHPNLIQSVDISKFQNTNYKTILNTDMVEFGGNTKKENLRDYDVYFNSTPPSSKMPIASRTAIVLLDNGI
>CP019857.1|AXU87483.1|2830754_2831396_+|TetR-family-transcriptional-regulator
MGRKKEPDNTIQKILDISHKLFLEKGYEQTTIQDIVDNLDGLSRGAIYHHFKSKDEIIKAITSRLYNDGFYGYEVKNDEGKTALEKLQYRLLHAYEQHNKQDIFLMSSSLLRNPKYLATQFDEIINDIVPWIKALIEEGNQDNSMEVKNPEIAAQMFGFLLNTWCIPTVYPGNPQQMIERFTLFGEQAAFMGISFMNDKIMCEYQKFVNKFSK

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Crispr_ID: CP019857_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP019857_16

3314685-3315427

Unclear

I-A

Consensus_repeat	Method
ATTTACATACCACTTAGTTAATATAAAAC	CRISPRCasFinder
ATTTACATACCACTTAGTTAATATAAAAC	CRT
GTTTTATATTAACTAAGTGGTATGTAAAT	PILER-CR
ATTTACATACCACTTAGTTAATATAAAAC	CRISPRCasFinder

11 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,WYL

The CRISPR arrays of CP019857_16

>merge|CP019857|16|3314685-3315427|CRISPRCasFinder,CRT,PILER-CR,CRISPRCasFinder
ATTTAGATATGATTTAGTTAATATAAGGTGGATGTTTTAGTATATGCTATTGTTGATTCTACAATTTTATATACTGCTTTATTAATATAAAATAAGTTTCTAAATACTCGTTGATATTGCTAATATTCTACTTATCTACCCTTAGTTGATATAAAACCTGACACTGTGCCTTGTGTGAGTCTTTTCTTTATCCTATTTACATACCACTTAGTTAATATAAAACGTTGTTAGATAAATCATATGCTTTAGTTGCTTTAGATTTACATACCACTTAGTTAATATAAAACACTTCGAAATTGCAGTTTTCAGCATGTTATTGCGCAATTTACATACCACTTAGTTAATATAAAACAAATTCGAGGTCTTGATTTTGAAGTTTTTGGTTATGCATTTACATACCACTTAGTTAATATAAAACGGTTTCTACCAATCAAATCACGCATAATTATAGAATTTACATACCACTTAGTTAATATAAAACAATCATTTTGTATGATTGTTCCATTTTTTTTGAAAACATTTACATACCACTTAGTTAATATAAAACCTCTGTGACTCCATATTTTTTTGCAATATATAATTCATTTACATACCACTTAGTTAATATAAAACCATTTGTAAATCTTTATGATTATGTAATATATTCATAATTTACATACCACTTAGTTAATATAAAACTTTTTGAATGTTGAAGATTTTGTTAATGCAGGGAAAATTTACATACCACTTAGTTAATATAAAAC

>CP019857|16|15|3314685-3314778|CRISPRCasFinder
ATTTAGATATGATTTAGTTAATATAAGGT	GGATGTTTTAGTATATGCTATTGTTGATTCTACAA
TTTTATATACTGCTTTATTAATATAAAATAAGTTTCTAAATACTCGTTGATATTGCTAATATTCTACTTATCTACCCTTAGTTGATATAAAACCTGACACTGTGCCTTGTGTGAGTCTTTTCTTTATCCTATTTACATACCACTTAGTTAATATAAAAC	GTTGTTAGATAAATCATATGCTTTAGTTGCTTTAG
ATTTACATACCACTTAGTTAATATAAAAC	ACTTCGAAATTGCAGTTTTCAGCATGTTATTGCGCA
ATTTACATACCACTTAGTTAATATAAAAC	AAATTCGAGGTCTTGATTTTGAAGTTTTTGGTTATGC
ATTTACATACCACTTAGTTAATATAAAAC	GGTTTCTACCAATCAAATCACGCATAATTATAGA
ATTTACATACCACTTAGTTAATATAAAAC	AATCATTTTGTATGATTGTTCCATTTTTTTTGAAAAC
ATTTACATACCACTTAGTTAATATAAAAC	CTCTGTGACTCCATATTTTTTTGCAATATATAATTC
ATTTACATACCACTTAGTTAATATAAAAC	CATTTGTAAATCTTTATGATTATGTAATATATTCATA
ATTTACATACCACTTAGTTAATATAAAAC	TTTTTGAATGTTGAAGATTTTGTTAATGCAGGGAAA


>CP019857|16|8|3314685-3315427|CRT
ATTTAGATATGATTTAGTTAATATAAGGT	GGATGTTTTAGTATATGCTATTGTTGATTCTACAA
TTTTATATACTGCTTTATTAATATAAAAT	AAGTTTCTAAATACTCGTTGATATTGCTAATATTC
TACTTATCTACCCTTAGTTGATATAAAAC	CTGACACTGTGCCTTGTGTGAGTCTTTTCTTTATCCT
ATTTACATACCACTTAGTTAATATAAAAC	GTTGTTAGATAAATCATATGCTTTAGTTGCTTTAG
ATTTACATACCACTTAGTTAATATAAAAC	ACTTCGAAATTGCAGTTTTCAGCATGTTATTGCGCA
ATTTACATACCACTTAGTTAATATAAAAC	AAATTCGAGGTCTTGATTTTGAAGTTTTTGGTTATGC
ATTTACATACCACTTAGTTAATATAAAAC	GGTTTCTACCAATCAAATCACGCATAATTATAGA
ATTTACATACCACTTAGTTAATATAAAAC	AATCATTTTGTATGATTGTTCCATTTTTTTTGAAAAC
ATTTACATACCACTTAGTTAATATAAAAC	CTCTGTGACTCCATATTTTTTTGCAATATATAATTC
ATTTACATACCACTTAGTTAATATAAAAC	CATTTGTAAATCTTTATGATTATGTAATATATTCATA
ATTTACATACCACTTAGTTAATATAAAAC	TTTTTGAATGTTGAAGATTTTGTTAATGCAGGGAAA
ATTTACATACCACTTAGTTAATATAAAAC

>CP019857|16|10|3314879-3315427|PILER-CR
ATTTACATACCACTTAGTTAATATAAAAC	GTTGTTAGATAAATCATATGCTTTAGTTGCTTTAG
ATTTACATACCACTTAGTTAATATAAAAC	ACTTCGAAATTGCAGTTTTCAGCATGTTATTGCGCA
ATTTACATACCACTTAGTTAATATAAAAC	AAATTCGAGGTCTTGATTTTGAAGTTTTTGGTTATGC
ATTTACATACCACTTAGTTAATATAAAAC	GGTTTCTACCAATCAAATCACGCATAATTATAGA
ATTTACATACCACTTAGTTAATATAAAAC	AATCATTTTGTATGATTGTTCCATTTTTTTTGAAAAC
ATTTACATACCACTTAGTTAATATAAAAC	CTCTGTGACTCCATATTTTTTTGCAATATATAATTC
ATTTACATACCACTTAGTTAATATAAAAC	CATTTGTAAATCTTTATGATTATGTAATATATTCATA
ATTTACATACCACTTAGTTAATATAAAAC	TTTTTGAATGTTGAAGATTTTGTTAATGCAGGGAAA
ATTTACATACCACTTAGTTAATATAAAAC

>CP019857|16|16|3314879-3315427|CRISPRCasFinder
	GGATGTTTTAGTATATGCTATTGTTGATTCTACAA
TTTTATATACTGCTTTATTAATATAAAATAAGTTTCTAAATACTCGTTGATATTGCTAATATTCTACTTATCTACCCTTAGTTGATATAAAACCTGACACTGTGCCTTGTGTGAGTCTTTTCTTTATCCTATTTACATACCACTTAGTTAATATAAAAC	GTTGTTAGATAAATCATATGCTTTAGTTGCTTTAG
ATTTACATACCACTTAGTTAATATAAAAC	ACTTCGAAATTGCAGTTTTCAGCATGTTATTGCGCA
ATTTACATACCACTTAGTTAATATAAAAC	AAATTCGAGGTCTTGATTTTGAAGTTTTTGGTTATGC
ATTTACATACCACTTAGTTAATATAAAAC	GGTTTCTACCAATCAAATCACGCATAATTATAGA
ATTTACATACCACTTAGTTAATATAAAAC	AATCATTTTGTATGATTGTTCCATTTTTTTTGAAAAC
ATTTACATACCACTTAGTTAATATAAAAC	CTCTGTGACTCCATATTTTTTTGCAATATATAATTC
ATTTACATACCACTTAGTTAATATAAAAC	CATTTGTAAATCTTTATGATTATGTAATATATTCATA
ATTTACATACCACTTAGTTAATATAAAAC	TTTTTGAATGTTGAAGATTTTGTTAATGCAGGGAAA
ATTTACATACCACTTAGTTAATATAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP019857.1\|AXU87863.1\|3307578_3307779_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87880.1\|3325273_3327190_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
CP019857.1\|AXU87872.1\|3315879_3316860_-\|maturase-related-protein	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
CP019857.1\|AXU87870.1\|3314195_3314624_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|236715
CP019857.1\|AXU87871.1\|3315610_3315877_-\|CRISPR-associated-Cas2-family-protein	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
CP019857.1\|AXU87866.1\|3309529_3310921_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341288
CP019857.1\|AXU87861.1\|3301925_3304145_-\|signaling-protein	unknown	unknown	gnl\|CDD\|238923
CP019857.1\|AXU87868.1\|3312092_3312638_-\|biotin-synthase	unknown	unknown	gnl\|CDD\|376871
CP019857.1\|AXU87867.1\|3310924_3312061_-\|thiolase	unknown	unknown	gnl\|CDD\|238383
CP019857.1\|AXU87877.1\|3321379_3323257_-\|CRISPR-associated-protein-Cas8a1/Cst1,-subtype-I-B/TNEAP	cas8b2	cd09665_cas8b2_CAS-I-B	gnl\|CDD\|187796
CP019857.1\|AXU87864.1\|3307985_3308576_-\|dipicolinate-synthase-subunit-B	unknown	unknown	gnl\|CDD\|181370
CP019857.1\|AXU87878.1\|3323262_3324000_-\|CRISPR-associated-Cas-family-protein	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|187783
CP019857.1\|AXU87869.1\|3312961_3313741_+\|hypothetical-protein	unknown	unknown	unknown
CP019857.1\|AXU87879.1\|3324077_3324965_-\|putative-transcriptional-regulator	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
CP019857.1\|AXU87873.1\|3316943_3317432_-\|CRISPR-associated-Cas4-family-protein	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
CP019857.1\|AXU87874.1\|3317428_3319750_-\|CRISPR-associated-helicase,-Cas3-family	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|273707
CP019857.1\|AXU87862.1\|3304420_3307075_-\|bifunctional-acetaldehyde-CoA/alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|237515
CP019857.1\|AXU87875.1\|3319760_3320462_-\|CRISPR-associated-protein,-Cas5t-family	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789
CP019857.1\|AXU87876.1\|3320463_3321378_-\|CRISPR-associated-autoregulator,-Cst2-family	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
CP019857.1\|AXU87865.1\|3308578_3309454_-\|dipicolinate-synthase-subunit-A	unknown	unknown	gnl\|CDD\|181371

Protein	Function_ID	Function_description	E-value
CP019857.1\|AXU87862.1\|3304420_3307075_-\|bifunctional-acetaldehyde-CoA/alcohol-dehydrogenase	gnl\|CDD\|237515	PRK13805, PRK13805, bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional.	0
CP019857.1\|AXU87880.1\|3325273_3327190_-\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	3.53563e-09
CP019857.1\|AXU87867.1\|3310924_3312061_-\|thiolase	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.84043e-108
CP019857.1\|AXU87870.1\|3314195_3314624_-\|acetyltransferase	gnl\|CDD\|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	8.2844e-47
CP019857.1\|AXU87866.1\|3309529_3310921_-\|AMP-binding-protein	gnl\|CDD\|341288	cd17633, AFD_YhfT-like, fatty acid-CoA ligase VraA. This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain	2.3784e-145
CP019857.1\|AXU87861.1\|3301925_3304145_-\|signaling-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.85244e-106
CP019857.1\|AXU87868.1\|3312092_3312638_-\|biotin-synthase	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	2.43536e-36
CP019857.1\|AXU87872.1\|3315879_3316860_-\|maturase-related-protein	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	9.94583e-175
CP019857.1\|AXU87877.1\|3321379_3323257_-\|CRISPR-associated-protein-Cas8a1/Cst1,-subtype-I-B/TNEAP	gnl\|CDD\|187796	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	2.53731e-23
CP019857.1\|AXU87864.1\|3307985_3308576_-\|dipicolinate-synthase-subunit-B	gnl\|CDD\|181370	PRK08305, spoVFB, dipicolinate synthase subunit B; Reviewed.	6.40655e-126
CP019857.1\|AXU87878.1\|3323262_3324000_-\|CRISPR-associated-Cas-family-protein	gnl\|CDD\|187783	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold.	1.41962e-19
CP019857.1\|AXU87871.1\|3315610_3315877_-\|CRISPR-associated-Cas2-family-protein	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.64696e-28
CP019857.1\|AXU87879.1\|3324077_3324965_-\|putative-transcriptional-regulator	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.87001e-40
CP019857.1\|AXU87874.1\|3317428_3319750_-\|CRISPR-associated-helicase,-Cas3-family	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	4.96654e-56
CP019857.1\|AXU87873.1\|3316943_3317432_-\|CRISPR-associated-Cas4-family-protein	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	9.9377e-49
CP019857.1\|AXU87875.1\|3319760_3320462_-\|CRISPR-associated-protein,-Cas5t-family	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	4.25968e-66
CP019857.1\|AXU87876.1\|3320463_3321378_-\|CRISPR-associated-autoregulator,-Cst2-family	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	1.87967e-53
CP019857.1\|AXU87865.1\|3308578_3309454_-\|dipicolinate-synthase-subunit-A	gnl\|CDD\|181371	PRK08306, PRK08306, dipicolinate synthase subunit DpsA.	7.6011e-131

>CP019857.1|AXU87870.1|3314195_3314624_-|acetyltransferase
MIKKLNNKDINKIMEIWEKSTIKAHDFISKEYWQNNYNTVKNEYIPISDTFVYDDGDEIKGFISIIDKSFIGALFIKPKYQNLGIGGKLLDYATKKYKSLSLAVYKDNKKAVVFYNKKGFNIVKEQVNEDSGFKEYIMEYSK
>CP019857.1|AXU87869.1|3312961_3313741_+|hypothetical-protein
MKVNENNINNIDEELDELSRKVYLESPDFWISISDKIIDKVFDEMLLFFAVKYNYFNIVCFAIENNYLDLNMPSKNKKYTNIMEHLLDTSKQNEDKKIYNYLLSLNKGNNLDERPILDELNCNISSDTFEKKDIYLPKYLCPSCNSNIFDTGYKVSNDITYKFSSKEAEPIEMCSEVSSIRCCNCDELLEDITLDKLYNLCKIQNCNNCGSNLTKVGIIAKKKMNFDENTEKFKDVSTSYCCGNCDSEINLSQREHFKI
>CP019857.1|AXU87868.1|3312092_3312638_-|biotin-synthase
MKNTKVNIQDLTKMSICVALLCISSYIYIPLPFTPAGVTAQTIMINLIALILTPRQAFSTVGVYIMIGLIGIPVFGGGTSGIGKLLSPTGGFYFGFLFAALIISLLKGRNNDIKRYILITIFVGMPIIYFMGTVFMCYFNQMTVEAALFAAVVPFLIGDTIKSVIASFLGTKLNNVLRRNL
>CP019857.1|AXU87867.1|3310924_3312061_-|thiolase
MKEVFILGGLRSHIGLKNGIFQFVQPELLGASVLKDLIKKYEIDKIDEIICGNAVGTGGNIARLMTLTAGVSNEVPAFTVDMQCASAMMSIDIAFSKVKSGQCDLIIAGGFESSSLQPMRTYHKNDKRYNTNNPNYTVAQFSPDDNSQNSMLEGAERVAELYQIEKADLDFWVKESHKRAKEAREEKILEDIISPINNSTYDEGIRDKMSQRLLDRMPSILGKETITNAANSCLINDGASFIIICSKKYLEHVKKKPKAKIINTCTIGTDATLSPTSAIQAMDKLLEIESLNYLDVSAVEFNEAFAVIDVLFQRKYPELIDRYNIFGGALAYGHPYGASGAIIALHLLKALEETKGRYGICSIAAAGGLGSALLLERV
>CP019857.1|AXU87866.1|3309529_3310921_-|AMP-binding-protein
MNYYELLRIKKERHKNKNFLIIDGEKYTYENLLSYSEELGKQISLGENIPILIYSKNIMFQLISFFAINYSKNIPIICHYNLSKKVLDDILLKNNISIIISDESMDVIDLYDDNNNEVAKKVNFSIFNPKFNIYMYQYKKLINYLDKSICMGALSSGSTSVPKVLYRTYESWAGFFPIQNGIFNISGESILFVNGTLSFTGNLNSIMSVLYEGGSIVISSGLNCKSWIRTIKQYNVTNIYLIPTKLQLLVKHLKEPVLKVVSIFTGSQLLFEDTARNLKKYMPKSEIILYYGASELNYITYLCYDELIEKPLSVGRPFPGIDIYIREGKIFVNTEYAVYNATKPYSVNDIGYYDNDGYLIFEGRSDDILNIGGFKVSSTKIENEVKKIPQIEDAIVLPYSDTIRGNQIVLFVITIDKITKKDLLIKMKDNLMKNEIPKKIIFLNSFPYTSSEKIDRLALLKML
>CP019857.1|AXU87865.1|3308578_3309454_-|dipicolinate-synthase-subunit-A
MSNQYDITVIGGDLRQVYMVKKLINKGYSVVTYGISNEIINGIVGKSTSLAEALSKSSIILCPIPFTKNQVNIENTDDCLDATIDNLLINLSPNQILFGGNIPTKVCKFCEQHSIQIYDFMKMNDVAILNAVATAEGAIAEAIKRSIINIHQSNCLVLGYGRCAQILAKKLYTLDANVCVGARNNDARSTANAFGYSSISLSQLDEKLLQFDYIFNTIPECILTKERLEKVSQEVTIIDIASSPGGVDYSVVKEAGINATLCLGLPGKYSPKTSGEILVNAIENIINERRD
>CP019857.1|AXU87864.1|3307985_3308576_-|dipicolinate-synthase-subunit-B
MRLEGLTIGVGFTGSFCTYDKIFIELENLVKEGANVHTIFSDVSQNIDCRFGNSEEFMKKAYELTGNKPIVTIEEAEPFGPKGIADIIIIAPCTGNTAAKLANGITDSPVLMAAKGHLRNDKPLVISISTNDALSFNFKNIGILLNSKNIYFVPFGQDNCKAKPNSMIAHTELIIPTIELALENKQLQPVIKSPHQ
>CP019857.1|AXU87863.1|3307578_3307779_+|hypothetical-protein
MKKLKTISIFSLIISVILTIGGIGIVTYYVDNLFIRGLSVFVLIMSSSFVSTTVRLIFEESKRYKF
>CP019857.1|AXU87862.1|3304420_3307075_-|bifunctional-acetaldehyde-CoA/alcohol-dehydrogenase
MAHKEQVIIENKKENEVMSVGLDTVNNVESLVKKLAKIREAQKIFATYSQEQVDKIFLAASLAANKQRVPLAIMAQKETGMGIAEDKVIKNHYASEYIYNAYKETKTCGVIEKDEAFGMTKIAEPIGVIAAVVPTTNPTSTAIFKALLALKTRNGIIFSPHPRAKNSTIEAAKVVLEAAVLAGAPEGIIGWIDEPSLELTTTVMKEVDLTLATGGPGMVKSAYSSGKPAIGVGAGNTPAIIDDSADIKTAVNSILVSKTFDNGMICASEQSVIVLENIYNEVKKEFKERGAYLLDKDETEKIRNIILVNGGLNSKIVGQTACTIAKLAGFEVPVDTKVLIGEVESVEIEEAFAHEKLSPVLAMYKASDFDDAVRKAEKLVEDGGFGHTSSLYIDDVNQREKLDKFTSAMKTCRILINTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVSENVGVKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVALKELKDVMNKKRAFIVTDTFLYNNGYTKAVTDLLDEMNIKHTTFFEVEPDPTLECAKIGAKAMREFNPDVIISIGGGSAMDAGKIMWTLYEHPDVDFQDLAMRFMDIRKRVYTFPKMGEKANFVAIPTSAGTGSEVTPFAVITDQDTGVKYPLADYELMPNMAIVDSDMMMNMPKSLTSASGIDALTHALEAYVSMLATDYTNGLALQAIKSIFEYLPRAYDNGAKDPEAREKMANASTMAGMAFANAFLGVCHSMAHKLGAFHHVPHGVANALLITEVMKFNSSDAPKKMGAFSQYKYPEALKRYAEIASFLGLKGNSDEEKFQSLLVAIEDLKLKVGIPKSIKEFGVEESKFMDSIDEMVIQAFDDQCTGANPRYPLMNEIKDMYLNSYYGR
>CP019857.1|AXU87861.1|3301925_3304145_-|signaling-protein
MTGRNKSFTLITILFLTSLFLTMGYIYIEDTKHLLMSEAKIHIKEVAVQGSQLAQRQIEKDLDVLNIFSNYYASNPDIPNEEKMKNLLDEMENQKFYTMAIVDINGNAENTKGDKFSVKDREFFKNSIKGKKYVSSPYVDEVNKSIKKIAISVPLLNNDKVVGVLYCTYNINTLMKLINISFYENNSISYVVKNNGTIILHPQGDSLSKNIYKLLKQDNDIQEVNRLKKELQENKTGATVLNMLEERRYLGYATMDNGNSENNYIKDWNLIFSIPETVVFSNSKQIINRAVYAVLSIVLIFIAIIFYIIYIKKSNEKEILSLAYEDKVTYIGNQNKFYRECSKYLLDKPSLNYIIVYFDINNFKMINDTFGYEFGDNLLITIAKALKEELTEGEVYARLSSDYFAIFCDYKNGRNKIIRKLDNIRSNIESNLSIVFEISLCVGIYFVEEGEVDIQKAVNKANMARSVAKGKNINYAIYNEDVRNKLSEESMILDDIKIALVKNQFEVYYQPKFSLVTGEMIGSEALIRWNHPEHGFISPAVFIPIAEKSKLILKIGRFVFERVCNDLYEWKKQGKKIVPVSVNLSRVELYQPDIVKFINKTIKMYNLSSDFIEIEITETVAINELNILKNVLNELRTYGFSISMDDFGTGYSSISCLRDMPIDILKLDKSFLGGIEHDERSRNIAKSIVSLAKSLDLVVIIEGVESKEQAELMKQFGCDLVQGFYFARPMPAKNFLDLL
>CP019857.1|AXU87871.1|3315610_3315877_-|CRISPR-associated-Cas2-family-protein
MFVIVTYDIVEARSLNRIRRILRKYLTWTQNSVFEGNITEGKLHKCISEIENIIDNSEDSIYVYEIKNPNSIKKKCYGIDKYSDEMFI
>CP019857.1|AXU87872.1|3315879_3316860_-|maturase-related-protein
MYKDYYIISNGDIKRKENTIYYYNLEGEKKILPVEQVDDIHIYGEVDLNTKLINYISKYGVMLHFYNYYGYYSGTYYPRKKNVSGFSLVCQSACYLDKNERLYLAKSFVESASYHILRNMRYYKVDESLIDTIKDELNDLNDVKEISELMGKEGRIRKTYYKSFNQILKDDFEFYKREKRPPKDPVNALMSFGNSIMYTNVLSEIYKTQLDPTISFLHEPSTKRFSLSLDIAEIFKPIIVDTIIFSLINNKRINKNDFEYQDKICYLSEKGKKKFLQEFENKMQTTIKHRNLNRKVSYRMFIRLECYKLIKHFINDERYKVLKVWW
>CP019857.1|AXU87873.1|3316943_3317432_-|CRISPR-associated-Cas4-family-protein
MIFILTMWLKFTKEGDFVPIDLEVLKVQGVKINYYYVCKRKLWLFSKGITMEQNSSRVLSGKIVHEDSYKRMKNKEILIDDILKLDIIKDEYVKEVKISSKMKEADEMQLYYYLYYLKNSMGIEKKGTINYVKEKKQEELILTEEKERIIENTLININEINM
>CP019857.1|AXU87874.1|3317428_3319750_-|CRISPR-associated-helicase,-Cas3-family
MLYAKSNPVETLREHTDELLKQMNVLRESYGKNINSLDFLEEEIFWQLLDFVIEFHDIGKAFSPFQELIKSRMDTKINEPKIVTHLENNVGHNYLSPAFIDYSYIDRKKNKELRAVLNQVIVYHHERDIFIDKDFKNLIQKILDEDLINKVYELQHEFKVRYPIKTERLSKVYLQSVEKRIDKNHKYYNLYIMLKGILHRLDHSASAHEVVECNNVINIGEQTENYLMKEFGSLREAQSFAKSNRNKNIILIASTGMGKTETALIWIDKDKAFFTLPLRVSINALFDRAKNIVGVGESNDTFLGLLHSTAIDYLEESNQENSSEIVDLAKLLSCKLTFSTIDQIFKFPFLYRGYEKVYSTLAYSKVVIDEIQAYSPEIAAVLVKGIEMIHKIGGRFMIMTATMPTIYIDELKKRGVMNSNLADLTCNTEKIRHCVSIVENSIDENLGKIIQSGMNKKVLVIVNTVKSAVEKYELIEEIVKPKGIDVNLNLLHSMYIQEDRAKLEKYIKEFADSDSNGIWITTQLVEASLDIDFDELHTENSTLDSLFQRFGRCYRSREYEENSPNIFIYTEKATGIGSIYDKDIVEKGLELLKTFINGKECVKMKEKYKVEMVKILYSKESLEGTAFEKRFTSALNILDTITPYSLGSKDAQNILRNIEGYTVIPEDIYNKIEETLIKDYEELGQELINAYSNDDRQLINKIKSKRKKARREIIKKTVNLPIYKAKQNVIDIQVKGLEDLKILLYKYDIHENKHTKQIFGKGVLISNEIDQFI
>CP019857.1|AXU87875.1|3319760_3320462_-|CRISPR-associated-protein,-Cas5t-family
MKVLKLDLFQETACYKKPFAMKITETYPLPPYSTINGLIHKVLNATEYIPFNISVQGTYESIFNNYQTTYFYKKDSITSMPMNSHMLLNVNLIIHIGGDFDLLEEIYDSLLNYDEHLSLGRKEDLVRINDIRFVEVNKFEVDEDIQLDDYENYKLSECNIRMPIYIPKTSLQDTDIDGISYRLNNYYDNNAVEDKKRVWNKVDSYYVEDGNTISIGDILLDNEGDLLYFNNIN
>CP019857.1|AXU87876.1|3320463_3321378_-|CRISPR-associated-autoregulator,-Cst2-family
MKRGLTFTVIAQAQSLNYGEGIGNISELKKLSRADGNMYTFASRQCLRYDIVRLAAELFNWNLQVVDKEKGTIQFKDNISIRESEEMDLFGYMKTNKKDEKDKKGGSLTREATVRLSNAISLEPYRSDMDFLNNKGFADRIGEHPNLANIEQHLSYYTYTVTIDLSKIGKDGDIELDNKEKCRRVVEFLEIIKVLNRNIRGRQENLSPLFVVGGVYEIANPFFLGRIKLKGDKNGFKINKQAIEEVIQGTFLGKDLKEFTYVGMVDGVFINKEEFKGLFEDNFLSVDKFFGQLVKEVKEYYGVN
>CP019857.1|AXU87877.1|3321379_3323257_-|CRISPR-associated-protein-Cas8a1/Cst1,-subtype-I-B/TNEAP
MKLRVYRGDWFFNMGIVGFLNIIKKADKQAEIFIMEDYIEFDSLFLENFHEYYFNYFMDEYDVSKRIKKNIDYSINFIKSKPDRIKDGIKKIKDSVKQQNDKIKKFDEEKFNLIKEKLDSMSKIKSYDEFDSLESLVDETIDIFKIKSINDRLTANLYKYVVQDNYFGQVSFFNVAKAKLDLDGLKQVMFNDYLRQIIYFGELEDLLEENDYDKLKNYLNDRLNSIAKDINEKKVSKSSINTIEKIMKEINKNFIKKNKSIEDIKEYMDSLEVCEMCGLYKGILDEYSESNFAPLGVSTNNARNMFWNQEYVSSICDVCKLILFCTPAGATYTRKNYLINEENEFYLFVNMDTSINELFERNNSLKAQKSESSDSKDENPFNQLIKSIVEENTLKSEWQLRNILFVEFKASIDSKKCKINYFNIPTYLAKFFTDKYANKKIQSIYDYKLKSNVLDLLLKNRDLKHLTNNILRNKVKNDMESNNKSNISGIDCFRVVQLRVLINSYKKGVYKMDSKNLEKNDEKLKIIYYLGCDIHDYFVNKNSKNKIDGVSYKLLNSVKVGNKSDFMDTIIRVFMSAEKQIPAFILDIEIEKDLDFESIGHAFISGLISGKYEGKDKLPNEKEEK
>CP019857.1|AXU87878.1|3323262_3324000_-|CRISPR-associated-Cas-family-protein
MKMKIEFSTGCIPISYNSLFMSIIKEAIRKSNEDYYKNMYYYKEKNNKKTKNFTFSVYIKKYSIEGDNFIIEDKVILNISTPDLELGFHIYNGLMTSKKCLYKAYELTRIRIDLSREKKVTEERVLFNALSPICVKSKEGKFLEITDDRYIEELNYITNEVVKNYRGNGLKRKLEFENIGLKKVVVKESLREFKKITGKEYQYINGYKGKFILKGDIDDLNLIYNLGIGFRRAQGFGDVDILEWR
>CP019857.1|AXU87879.1|3324077_3324965_-|putative-transcriptional-regulator
MKCKELSEELEVSERQIKSYKMYLEQAGIFINSTPGIYGGYEIDKCNSISLIKLLDSEVSILDMINSQLEYNNDIYKNEFNNIVEKIKAVLNTGEKSDTYMDYFTVQAQRNCDYESEKNKCNEIIRAYTTKHKFWIEYYSLNSGNSERIVHPYGLFNYKSDTYMVAFCEKRFKFIDFKLCRIKDYKVLEEKYNVDKSFSWDEYSKNSIGIYKGEEINVVIKISHPFSTIIKEKVWVNNQQIIEYDDKSIMFKAKMRGYEEIKSWILSMGAYVEVVEPDRLRNDILSEIEKMKKIY
>CP019857.1|AXU87880.1|3325273_3327190_-|ABC-transporter-permease
MNIKQFAINNISRNIKAYLGYLASIVISSSLLFSFIMFTSHPDLDVSQFPDYLKEGLKMSKIIAYLFLFFFVFYSVSVFLKSRYKEFGILYITGISKRQVMKLIFIENMIINIVSSVIGIIIGLIFAKIFLVVMSTFLELSPLKFYIPFNAILSTLIYFMILAVLTSIFTSFIVKENQVLKLLKGTKTPKPEPKTSLMLAILSICLFIIAYYNAITSTDQYTTYLRLVPVTSLTIVATYLFFSQFSVFFMKKLKLNKRFYRKNTNMLWISNLIYKVKDNARIFFLITITSAVAFTAIGTVYSFWKDVERQINLIYPNTIYYSTMTLHNDPKKPDSKEKDKERMMFIENNLKKEDVDYTRTNGEFKTVFPKKSDFNVRIMKESKYLEITETIGVKPISFEDNECISLLSSSLPGNNNVKENIIVGNRGLKVAKQVEECVMPAYYKNMYVVKDNFYDSIESKFIVDRFTAFEVEDSSKTIEICREFENKFNNESGMQPYLFFSKELMIGTGKLMYSTFIFLAIFIGLIFFVTTSSFLYNKFYMDCQVDKKKYEQLNKLGMTYNEIKKASTIEIGIVFLFPYVVAVIHSIFALTALKNSFDIEVASSAVLVMGSLFLVQIVYFLIVRNNYLKEIRLNLVNF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP019857_1	1.1\|146650\|29\|CP019857\|CRISPRCasFinder	146650-146678	29	NZ_CP033215	Clostridioides difficile strain 12038 plasmid unnamed1, complete sequence	5105-5133	0	1.0
CP019857_4	4.2\|1317730\|37\|CP019857\|CRISPRCasFinder,PILER-CR	1317730-1317766	37	HG531805	Clostridium phage CDMH1 complete genome	9722-9758	0	1.0
CP019857_4	4.3\|1317796\|36\|CP019857\|CRISPRCasFinder,PILER-CR	1317796-1317831	36	NZ_CP029155	Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence	52281-52316	0	1.0
CP019857_4	4.3\|1317796\|36\|CP019857\|CRISPRCasFinder,PILER-CR	1317796-1317831	36	MF547662	Clostridioides phage LIBA6276, complete genome	133621-133656	0	1.0
CP019857_7	7.5\|1646676\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1646676-1646711	36	NZ_CP029155	Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence	39008-39043	0	1.0
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	NC_028958	Clostridium phage phiCD146, complete genome	14871-14907	0	1.0
CP019857_9	9.4\|2570076\|36\|CP019857\|CRISPRCasFinder	2570076-2570111	36	NZ_MF547664	Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence	25530-25565	0	1.0
CP019857_9	9.11\|2570076\|37\|CP019857\|CRT,PILER-CR	2570076-2570112	37	NZ_MF547664	Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence	25530-25566	0	1.0
CP019857_11	11.2\|2817126\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817126-2817162	37	LN680005	Clostridium phage phiCDHM4 gp01 gene for putative capsid protein	620-656	0	1.0
CP019857_16	16.9\|3315232\|36\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315232-3315267	36	NC_028958	Clostridium phage phiCD146, complete genome	3353-3388	0	1.0
CP019857_3	3.1\|1314727\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314727-1314763	37	KU057941	Clostridium phage CDSH1, complete genome	26166-26202	1	0.973
CP019857_3	3.1\|1314727\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314727-1314763	37	NC_028905	Clostridium phage phiCD111, complete genome	25940-25976	1	0.973
CP019857_3	3.1\|1314727\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314727-1314763	37	HM568888	Clostridium phage phiCD38-2, complete genome	25662-25698	1	0.973
CP019857_3	3.1\|1314727\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314727-1314763	37	NC_028958	Clostridium phage phiCD146, complete genome	25224-25260	1	0.973
CP019857_3	3.1\|1314727\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314727-1314763	37	LN881738	Escherichia phage slur17, complete genome	35854-35890	1	0.973
CP019857_4	4.5\|1317927\|38\|CP019857\|CRISPRCasFinder	1317927-1317964	38	NZ_MG973074	Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence	98918-98955	1	0.974
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	GU949551	Clostridium phage phiCD6356, complete genome	25335-25372	1	0.974
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	JX145342	Clostridium phage phiMMP04, complete genome	21201-21238	1	0.974
CP019857_6	6.9\|1535793\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535793-1535828	36	MF547662	Clostridioides phage LIBA6276, complete genome	122735-122770	1	0.972
CP019857_6	6.9\|1535793\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535793-1535828	36	MF547663	Clostridioides phage LIBA2945, complete genome	120998-121033	1	0.972
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	LN881738	Escherichia phage slur17, complete genome	5035-5071	1	0.973
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	KU057941	Clostridium phage CDSH1, complete genome	15366-15402	1	0.973
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	HM568888	Clostridium phage phiCD38-2, complete genome	14862-14898	1	0.973
CP019857_9	9.3\|2570010\|37\|CP019857\|CRISPRCasFinder	2570010-2570046	37	JX145342	Clostridium phage phiMMP04, complete genome	12593-12629	1	0.973
CP019857_9	9.5\|2570141\|38\|CP019857\|CRISPRCasFinder	2570141-2570178	38	NZ_MF547664	Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence	15483-15520	1	0.974
CP019857_11	11.4\|2817260\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817260-2817296	37	JX145341	Clostridium phage phiMMP02, complete genome	46771-46807	1	0.973
CP019857_11	11.4\|2817260\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817260-2817296	37	KX228400	Clostridium phage CDKM15, complete genome	49015-49051	1	0.973
CP019857_11	11.5\|2817326\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817326-2817362	37	NZ_CP029156	Clostridioides difficile strain CD161 plasmid unnamed2, complete sequence	27938-27974	1	0.973
CP019857_11	11.5\|2817326\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817326-2817362	37	NZ_CP029153	Clostridioides difficile strain CDT4 plasmid unnamed1, complete sequence	21982-22018	1	0.973
CP019857_11	11.5\|2817326\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817326-2817362	37	LN681541	Clostridium phage phiMMP01, complete genome	23007-23043	1	0.973
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	MK473382	Clostridium phage JD032, complete genome	12261-12297	1	0.973
CP019857_2	2.3\|1290789\|38\|CP019857\|CRISPRCasFinder,CRT	1290789-1290826	38	AY855346	Clostridium difficile bacteriophage phi CD119, complete genome	33007-33044	2	0.947
CP019857_2	2.3\|1290789\|38\|CP019857\|CRISPRCasFinder,CRT	1290789-1290826	38	NC_007917	Clostridium phage phi CD119, complete genome	33007-33044	2	0.947
CP019857_2	2.3\|1290789\|38\|CP019857\|CRISPRCasFinder,CRT	1290789-1290826	38	NC_028996	Clostridium phage phiCDHM19, complete genome	36695-36732	2	0.947
CP019857_4	4.3\|1317796\|36\|CP019857\|CRISPRCasFinder,PILER-CR	1317796-1317831	36	NZ_CP020426	Clostridioides difficile strain FDAARGOS_267 plasmid unnamed2, complete sequence	122581-122616	2	0.944
CP019857_4	4.3\|1317796\|36\|CP019857\|CRISPRCasFinder,PILER-CR	1317796-1317831	36	CP011970	Peptoclostridium phage phiCDIF1296T strain DSM 1296, complete sequence	130710-130745	2	0.944
CP019857_4	4.3\|1317796\|36\|CP019857\|CRISPRCasFinder,PILER-CR	1317796-1317831	36	LN681537	Clostridium phage phiCD211, complete genome	8246-8281	2	0.944
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	KU057941	Clostridium phage CDSH1, complete genome	30134-30171	2	0.947
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	LN881738	Escherichia phage slur17, complete genome	31885-31922	2	0.947
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	NC_028905	Clostridium phage phiCD111, complete genome	29929-29966	2	0.947
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	NC_028838	Clostridium phage phiCD506, complete genome	23555-23592	2	0.947
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	HM568888	Clostridium phage phiCD38-2, complete genome	29628-29665	2	0.947
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	NC_028958	Clostridium phage phiCD146, complete genome	29191-29228	2	0.947
CP019857_8	8.7\|1848425\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848425-1848461	37	FN668942	Clostridium difficile BI1 plasmid pCDBI1, complete sequence	28536-28572	2	0.946
CP019857_9	9.1\|2569880\|36\|CP019857\|CRISPRCasFinder	2569880-2569915	36	NZ_MG973074	Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence	22132-22167	2	0.944
CP019857_9	9.8\|2569880\|37\|CP019857\|CRT	2569880-2569916	37	NZ_MG973074	Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence	22132-22168	2	0.946
CP019857_9	9.10\|2570010\|38\|CP019857\|CRT,PILER-CR	2570010-2570047	38	JX145342	Clostridium phage phiMMP04, complete genome	12593-12630	2	0.947
CP019857_9	9.12\|2570141\|39\|CP019857\|CRT,PILER-CR	2570141-2570179	39	NZ_MF547664	Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence	15483-15521	2	0.949
CP019857_11	11.7\|2817458\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817458-2817495	38	NC_028905	Clostridium phage phiCD111, complete genome	3624-3661	2	0.947
CP019857_16	16.7\|3315103\|34\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315103-3315136	34	NC_028905	Clostridium phage phiCD111, complete genome	16242-16275	2	0.941
CP019857_16	16.7\|3315103\|34\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315103-3315136	34	NC_028958	Clostridium phage phiCD146, complete genome	15720-15753	2	0.941
CP019857_6	6.5\|1535529\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1535529-1535566	38	MK473382	Clostridium phage JD032, complete genome	10693-10730	3	0.921
CP019857_7	7.7\|1646808\|38\|CP019857\|CRISPRCasFinder,CRT	1646808-1646845	38	NZ_MG973074	Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence	94861-94898	4	0.895
CP019857_8	8.7\|1848425\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848425-1848461	37	NZ_CP020425	Clostridioides difficile strain FDAARGOS_267 plasmid unnamed1, complete sequence	29892-29928	4	0.892
CP019857_8	8.7\|1848425\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848425-1848461	37	NZ_CP011969	Clostridioides difficile ATCC 9689 = DSM 1296 plasmid unnamed, complete sequence	25214-25250	4	0.892
CP019857_8	8.12\|1848755\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848755-1848790	36	KU057941	Clostridium phage CDSH1, complete genome	26553-26588	4	0.889
CP019857_8	8.12\|1848755\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848755-1848790	36	NC_028905	Clostridium phage phiCD111, complete genome	26327-26362	4	0.889
CP019857_8	8.12\|1848755\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848755-1848790	36	HM568888	Clostridium phage phiCD38-2, complete genome	26049-26084	4	0.889
CP019857_8	8.12\|1848755\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848755-1848790	36	NC_028958	Clostridium phage phiCD146, complete genome	25611-25646	4	0.889
CP019857_8	8.12\|1848755\|36\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848755-1848790	36	LN881738	Escherichia phage slur17, complete genome	35468-35503	4	0.889
CP019857_3	3.2\|1314793\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314793-1314829	37	HG531805	Clostridium phage CDMH1 complete genome	16500-16536	5	0.865
CP019857_1	1.1\|146650\|29\|CP019857\|CRISPRCasFinder	146650-146678	29	KY971610	Pseudomonas phage PspYZU05, complete genome	134239-134267	6	0.793
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	KU057941	Clostridium phage CDSH1, complete genome	28567-28603	6	0.838
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	NC_028905	Clostridium phage phiCD111, complete genome	28341-28377	6	0.838
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	LN881738	Escherichia phage slur17, complete genome	33453-33489	6	0.838
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	NC_048665	Clostridium phage phiCDHM14, complete genome	22171-22207	7	0.811
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	HG796225	Clostridium phage phiCDHM13 complete genome	21671-21707	7	0.811
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	LN681538	Clostridium phage phiCD481-1, complete genome	21411-21447	7	0.811
CP019857_16	16.8\|3315166\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315166-3315202	37	HG798901	Clostridium phage phiCDHM11 complete genome	21671-21707	7	0.811
CP019857_11	11.7\|2817458\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817458-2817495	38	MK448895	Streptococcus phage Javan274, complete genome	1703-1740	9	0.763
CP019857_11	11.7\|2817458\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817458-2817495	38	MK448769	Streptococcus phage Javan471, complete genome	1703-1740	9	0.763
CP019857_11	11.7\|2817458\|38\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817458-2817495	38	MK448684	Streptococcus phage Javan151, complete genome	1703-1740	9	0.763
CP019857_16	16.11\|3315363\|36\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315363-3315398	36	MN693244	Marine virus AFVG_25M166, complete genome	11363-11398	9	0.75
CP019857_2	2.2\|1290723\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1290723-1290759	37	NZ_CP029750	Staphylococcus aureus strain Smith plasmid pSS41, complete sequence	5815-5851	10	0.73
CP019857_3	3.2\|1314793\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1314793-1314829	37	NZ_CP013332	Fusobacterium hwasookii ChDC F174 plasmid unnamed1, complete sequence	18389-18425	10	0.73
CP019857_4	4.1\|1317663\|38\|CP019857\|CRISPRCasFinder	1317663-1317700	38	LC168164	Tenacibaculum phage pT24 DNA, complete genome	82711-82748	10	0.737
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	NC_028958	Clostridium phage phiCD146, complete genome	14739-14775	10	0.73
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	LN881738	Escherichia phage slur17, complete genome	5167-5203	10	0.73
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	KU057941	Clostridium phage CDSH1, complete genome	15234-15270	10	0.73
CP019857_8	8.13\|1848820\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	1848820-1848856	37	HM568888	Clostridium phage phiCD38-2, complete genome	14730-14766	10	0.73
CP019857_16	16.9\|3315232\|36\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315232-3315267	36	MK448421	Streptococcus satellite phage Javan312, complete genome	4648-4683	10	0.722
CP019857_16	16.11\|3315363\|36\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315363-3315398	36	NC_019782	Lactobacillus phage AQ113, complete genome	9402-9437	10	0.722
CP019857_11	11.2\|2817126\|37\|CP019857\|PILER-CR,CRISPRCasFinder,CRT	2817126-2817162	37	MN693317	Marine virus AFVG_25M47, complete genome	11036-11072	11	0.703
CP019857_16	16.10\|3315297\|37\|CP019857\|CRT,PILER-CR,CRISPRCasFinder	3315297-3315333	37	NZ_CP023496	Staphylococcus simulans strain FDAARGOS_383 plasmid unnamed, complete sequence	97606-97642	11	0.703

1. spacer 1.1|146650|29|CP019857|CRISPRCasFinder matches to NZ_CP033215 (Clostridioides difficile strain 12038 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

tgtaataagttaaagcaatatgaatcaac	CRISPR spacer
tgtaataagttaaagcaatatgaatcaac	Protospacer
*****************************

2. spacer 4.2|1317730|37|CP019857|CRISPRCasFinder,PILER-CR matches to HG531805 (Clostridium phage CDMH1 complete genome) position: , mismatch: 0, identity: 1.0

gtttttaaagcttcttcaagttgtatttgtgtataat	CRISPR spacer
gtttttaaagcttcttcaagttgtatttgtgtataat	Protospacer
*************************************

3. spacer 4.3|1317796|36|CP019857|CRISPRCasFinder,PILER-CR matches to NZ_CP029155 (Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

ccaactgaataaacaataattttatcaatttcttta	CRISPR spacer
ccaactgaataaacaataattttatcaatttcttta	Protospacer
************************************

4. spacer 4.3|1317796|36|CP019857|CRISPRCasFinder,PILER-CR matches to MF547662 (Clostridioides phage LIBA6276, complete genome) position: , mismatch: 0, identity: 1.0

ccaactgaataaacaataattttatcaatttcttta	CRISPR spacer
ccaactgaataaacaataattttatcaatttcttta	Protospacer
************************************

5. spacer 7.5|1646676|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029155 (Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

atttgattttaatggtacgttttcgctttctctaag	CRISPR spacer
atttgattttaatggtacgttttcgctttctctaag	Protospacer
************************************

6. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 0, identity: 1.0

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gaaataataaatagcattgtcgaatggtttgcaagcc	Protospacer
*************************************

7. spacer 9.4|2570076|36|CP019857|CRISPRCasFinder matches to NZ_MF547664 (Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence) position: , mismatch: 0, identity: 1.0

aagacttaacacagtaactaaactgtacataattgg	CRISPR spacer
aagacttaacacagtaactaaactgtacataattgg	Protospacer
************************************

8. spacer 9.11|2570076|37|CP019857|CRT,PILER-CR matches to NZ_MF547664 (Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence) position: , mismatch: 0, identity: 1.0

aagacttaacacagtaactaaactgtacataattggt	CRISPR spacer
aagacttaacacagtaactaaactgtacataattggt	Protospacer
*************************************

9. spacer 11.2|2817126|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN680005 (Clostridium phage phiCDHM4 gp01 gene for putative capsid protein) position: , mismatch: 0, identity: 1.0

tctaatttaatagctttatttttagcaaaatacccaa	CRISPR spacer
tctaatttaatagctttatttttagcaaaatacccaa	Protospacer
*************************************

10. spacer 16.9|3315232|36|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 0, identity: 1.0

ctctgtgactccatatttttttgcaatatataattc	CRISPR spacer
ctctgtgactccatatttttttgcaatatataattc	Protospacer
************************************

11. spacer 3.1|1314727|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to KU057941 (Clostridium phage CDSH1, complete genome) position: , mismatch: 1, identity: 0.973

aatttttcgagagtctcaatttacagaagaaattgga	CRISPR spacer
gatttttcgagagtctcaatttacagaagaaattgga	Protospacer
.************************************

12. spacer 3.1|1314727|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028905 (Clostridium phage phiCD111, complete genome) position: , mismatch: 1, identity: 0.973

aatttttcgagagtctcaatttacagaagaaattgga	CRISPR spacer
gatttttcgagagtctcaatttacagaagaaattgga	Protospacer
.************************************

13. spacer 3.1|1314727|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to HM568888 (Clostridium phage phiCD38-2, complete genome) position: , mismatch: 1, identity: 0.973

aatttttcgagagtctcaatttacagaagaaattgga	CRISPR spacer
gatttttcgagagtctcaatttacagaagaaattgga	Protospacer
.************************************

14. spacer 3.1|1314727|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 1, identity: 0.973

aatttttcgagagtctcaatttacagaagaaattgga	CRISPR spacer
gatttttcgagagtctcaatttacagaagaaattgga	Protospacer
.************************************

15. spacer 3.1|1314727|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN881738 (Escherichia phage slur17, complete genome) position: , mismatch: 1, identity: 0.973

aatttttcgagagtctcaatttacagaagaaattgga	CRISPR spacer
gatttttcgagagtctcaatttacagaagaaattgga	Protospacer
.************************************

16. spacer 4.5|1317927|38|CP019857|CRISPRCasFinder matches to NZ_MG973074 (Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence) position: , mismatch: 1, identity: 0.974

aaagcaaaagataggaatgataattttaaaactccaaa	CRISPR spacer
aaagcaaaagacaggaatgataattttaaaactccaaa	Protospacer
***********.**************************

17. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to GU949551 (Clostridium phage phiCD6356, complete genome) position: , mismatch: 1, identity: 0.974

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattctctctaggcttatccttacag	Protospacer
*************************************.

18. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to JX145342 (Clostridium phage phiMMP04, complete genome) position: , mismatch: 1, identity: 0.974

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattctctctaggcttatccttacag	Protospacer
*************************************.

19. spacer 6.9|1535793|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MF547662 (Clostridioides phage LIBA6276, complete genome) position: , mismatch: 1, identity: 0.972

agagtaaaacaatagtacaagaacaaataaatacat	CRISPR spacer
aaagtaaaacaatagtacaagaacaaataaatacat	Protospacer
*.**********************************

20. spacer 6.9|1535793|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MF547663 (Clostridioides phage LIBA2945, complete genome) position: , mismatch: 1, identity: 0.972

agagtaaaacaatagtacaagaacaaataaatacat	CRISPR spacer
aaagtaaaacaatagtacaagaacaaataaatacat	Protospacer
*.**********************************

21. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN881738 (Escherichia phage slur17, complete genome) position: , mismatch: 1, identity: 0.973

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gaaataataaatagcattgtcgaatggtttgtaagcc	Protospacer
*******************************.*****

22. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to KU057941 (Clostridium phage CDSH1, complete genome) position: , mismatch: 1, identity: 0.973

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gaaataataaatagcattgtcgaatggtttgtaagcc	Protospacer
*******************************.*****

23. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to HM568888 (Clostridium phage phiCD38-2, complete genome) position: , mismatch: 1, identity: 0.973

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gaaataataaatagcattgtcgaatggtttgtaagcc	Protospacer
*******************************.*****

24. spacer 9.3|2570010|37|CP019857|CRISPRCasFinder matches to JX145342 (Clostridium phage phiMMP04, complete genome) position: , mismatch: 1, identity: 0.973

aagcatatacacatgtcagaagatatttataaaagga	CRISPR spacer
aagcatatacacatgtcagaagatatttataaaaggt	Protospacer
************************************

25. spacer 9.5|2570141|38|CP019857|CRISPRCasFinder matches to NZ_MF547664 (Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence) position: , mismatch: 1, identity: 0.974

gatataataatgaaacctttttttaaacttattttctt	CRISPR spacer
gatagaataatgaaacctttttttaaacttattttctt	Protospacer
**** *********************************

26. spacer 11.4|2817260|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to JX145341 (Clostridium phage phiMMP02, complete genome) position: , mismatch: 1, identity: 0.973

aaatgctgaaagataattcggttggggatttaatgaa	CRISPR spacer
aaatgttgaaagataattcggttggggatttaatgaa	Protospacer
*****.*******************************

27. spacer 11.4|2817260|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to KX228400 (Clostridium phage CDKM15, complete genome) position: , mismatch: 1, identity: 0.973

aaatgctgaaagataattcggttggggatttaatgaa	CRISPR spacer
aaatgttgaaagataattcggttggggatttaatgaa	Protospacer
*****.*******************************

28. spacer 11.5|2817326|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029156 (Clostridioides difficile strain CD161 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.973

taaatagagcagatgaggcttttcaagaagccgatag	CRISPR spacer
tagatagagcagatgaggcttttcaagaagccgatag	Protospacer
**.**********************************

29. spacer 11.5|2817326|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029153 (Clostridioides difficile strain CDT4 plasmid unnamed1, complete sequence) position: , mismatch: 1, identity: 0.973

taaatagagcagatgaggcttttcaagaagccgatag	CRISPR spacer
tagatagagcagatgaggcttttcaagaagccgatag	Protospacer
**.**********************************

30. spacer 11.5|2817326|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN681541 (Clostridium phage phiMMP01, complete genome) position: , mismatch: 1, identity: 0.973

taaatagagcagatgaggcttttcaagaagccgatag	CRISPR spacer
tagatagagcagatgaggcttttcaagaagccgatag	Protospacer
**.**********************************

31. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to MK473382 (Clostridium phage JD032, complete genome) position: , mismatch: 1, identity: 0.973

aatcattttgtatgattgttccattttttttgaaaac	CRISPR spacer
aatcattttgtatgattgttccattttttttaaaaac	Protospacer
*******************************.*****

32. spacer 2.3|1290789|38|CP019857|CRISPRCasFinder,CRT matches to AY855346 (Clostridium difficile bacteriophage phi CD119, complete genome) position: , mismatch: 2, identity: 0.947

gaccaagatacttgaaaaaatatcgctgactattttga	CRISPR spacer
gatcaagatactttaaaaaatatcgctgactattttga	Protospacer
**.********** ************************

33. spacer 2.3|1290789|38|CP019857|CRISPRCasFinder,CRT matches to NC_007917 (Clostridium phage phi CD119, complete genome) position: , mismatch: 2, identity: 0.947

gaccaagatacttgaaaaaatatcgctgactattttga	CRISPR spacer
gatcaagatactttaaaaaatatcgctgactattttga	Protospacer
**.********** ************************

34. spacer 2.3|1290789|38|CP019857|CRISPRCasFinder,CRT matches to NC_028996 (Clostridium phage phiCDHM19, complete genome) position: , mismatch: 2, identity: 0.947

gaccaagatacttgaaaaaatatcgctgactattttga	CRISPR spacer
gatcaagatactttaaaaaatatcgctgactattttga	Protospacer
**.********** ************************

35. spacer 4.3|1317796|36|CP019857|CRISPRCasFinder,PILER-CR matches to NZ_CP020426 (Clostridioides difficile strain FDAARGOS_267 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.944

ccaactgaataaacaataattttatcaatttcttta	CRISPR spacer
cctattgaataaacaataattttatcaatttcttta	Protospacer
** *.*******************************

36. spacer 4.3|1317796|36|CP019857|CRISPRCasFinder,PILER-CR matches to CP011970 (Peptoclostridium phage phiCDIF1296T strain DSM 1296, complete sequence) position: , mismatch: 2, identity: 0.944

ccaactgaataaacaataattttatcaatttcttta	CRISPR spacer
cctattgaataaacaataattttatcaatttcttta	Protospacer
** *.*******************************

37. spacer 4.3|1317796|36|CP019857|CRISPRCasFinder,PILER-CR matches to LN681537 (Clostridium phage phiCD211, complete genome) position: , mismatch: 2, identity: 0.944

ccaactgaataaacaataattttatcaatttcttta	CRISPR spacer
cctattgaataaacaataattttatcaatttcttta	Protospacer
** *.*******************************

38. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to KU057941 (Clostridium phage CDSH1, complete genome) position: , mismatch: 2, identity: 0.947

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattccctctaggcttatccttacag	Protospacer
*****************.*******************.

39. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN881738 (Escherichia phage slur17, complete genome) position: , mismatch: 2, identity: 0.947

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattccctctaggcttatccttacag	Protospacer
*****************.*******************.

40. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028905 (Clostridium phage phiCD111, complete genome) position: , mismatch: 2, identity: 0.947

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattccctctaggcttatccttacag	Protospacer
*****************.*******************.

41. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028838 (Clostridium phage phiCD506, complete genome) position: , mismatch: 2, identity: 0.947

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattccctctaggcttatccttacag	Protospacer
*****************.*******************.

42. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to HM568888 (Clostridium phage phiCD38-2, complete genome) position: , mismatch: 2, identity: 0.947

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattccctctaggcttatccttacag	Protospacer
*****************.*******************.

43. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 2, identity: 0.947

agagagaagggctattctctctaggcttatccttacaa	CRISPR spacer
agagagaagggctattccctctaggcttatccttacag	Protospacer
*****************.*******************.

44. spacer 8.7|1848425|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to FN668942 (Clostridium difficile BI1 plasmid pCDBI1, complete sequence) position: , mismatch: 2, identity: 0.946

ctgatagaaaaagaagattatttgaaagttgagacta	CRISPR spacer
ttggtagaaaaagaagattatttgaaagttgagacta	Protospacer
.**.*********************************

45. spacer 9.1|2569880|36|CP019857|CRISPRCasFinder matches to NZ_MG973074 (Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence) position: , mismatch: 2, identity: 0.944

acaattattaattgttttattattgaaatcacagca	CRISPR spacer
acaattattaattgttttattaataaaatcacagca	Protospacer
********************** *.***********

46. spacer 9.8|2569880|37|CP019857|CRT matches to NZ_MG973074 (Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence) position: , mismatch: 2, identity: 0.946

acaattattaattgttttattattgaaatcacagcaa	CRISPR spacer
acaattattaattgttttattaataaaatcacagcaa	Protospacer
********************** *.************

47. spacer 9.10|2570010|38|CP019857|CRT,PILER-CR matches to JX145342 (Clostridium phage phiMMP04, complete genome) position: , mismatch: 2, identity: 0.947

aagcatatacacatgtcagaagatatttataaaaggat	CRISPR spacer
aagcatatacacatgtcagaagatatttataaaaggtg	Protospacer
************************************

48. spacer 9.12|2570141|39|CP019857|CRT,PILER-CR matches to NZ_MF547664 (Clostridioides difficile strain LIBA-6289 plasmid LIBA6289, complete sequence) position: , mismatch: 2, identity: 0.949

gatataataatgaaacctttttttaaacttattttcttt	CRISPR spacer
gatagaataatgaaacctttttttaaacttattttctta	Protospacer
**** *********************************

49. spacer 11.7|2817458|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028905 (Clostridium phage phiCD111, complete genome) position: , mismatch: 2, identity: 0.947

gctgataaagttattaaaagtaaaattgctgaaatact	CRISPR spacer
gctgataaagttattaaaaggaaaattgctgaaacact	Protospacer
******************** *************.***

50. spacer 16.7|3315103|34|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NC_028905 (Clostridium phage phiCD111, complete genome) position: , mismatch: 2, identity: 0.941

ggtttctaccaatcaaatcacgcataattataga	CRISPR spacer
ggtttctaccaatcaaatcacgcatgattatgga	Protospacer
*************************.*****.**

51. spacer 16.7|3315103|34|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 2, identity: 0.941

ggtttctaccaatcaaatcacgcataattataga	CRISPR spacer
ggtttctaccaattaaatctcgcataattataga	Protospacer
*************.***** **************

52. spacer 6.5|1535529|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MK473382 (Clostridium phage JD032, complete genome) position: , mismatch: 3, identity: 0.921

agagagaagggctattctctctaggcttatccttacaa-	CRISPR spacer
agagagaagggttattctctctaggc-tatccttacagc	Protospacer
***********.************** **********.

53. spacer 7.7|1646808|38|CP019857|CRISPRCasFinder,CRT matches to NZ_MG973074 (Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence) position: , mismatch: 4, identity: 0.895

ctatcttttgttgctttacataaatttatattacttat	CRISPR spacer
ccatcttttgttgctttgcatagatttatattacttac	Protospacer
*.***************.****.**************.

54. spacer 8.7|1848425|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020425 (Clostridioides difficile strain FDAARGOS_267 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.892

ctgatagaaaaagaagattatttgaaagttgagacta	CRISPR spacer
ttaatagaaaaagaagaatatttaaaagttgagacta	Protospacer
.*.************** *****.*************

55. spacer 8.7|1848425|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011969 (Clostridioides difficile ATCC 9689 = DSM 1296 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

ctgatagaaaaagaagattatttgaaagttgagacta	CRISPR spacer
ttaatagaaaaagaagaatatttaaaagttgagacta	Protospacer
.*.************** *****.*************

56. spacer 8.12|1848755|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to KU057941 (Clostridium phage CDSH1, complete genome) position: , mismatch: 4, identity: 0.889

aatatttagagatggcgtagagtgttaaaagtttca	CRISPR spacer
aatatttagagatggtgtagagtgttaaaaattttg	Protospacer
***************.**************.***..

57. spacer 8.12|1848755|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028905 (Clostridium phage phiCD111, complete genome) position: , mismatch: 4, identity: 0.889

aatatttagagatggcgtagagtgttaaaagtttca	CRISPR spacer
aatatttagagatggtgtagagtgttaaaaattttg	Protospacer
***************.**************.***..

58. spacer 8.12|1848755|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to HM568888 (Clostridium phage phiCD38-2, complete genome) position: , mismatch: 4, identity: 0.889

aatatttagagatggcgtagagtgttaaaagtttca	CRISPR spacer
aatatttagagatggtgtagagtgttaaaaattttg	Protospacer
***************.**************.***..

59. spacer 8.12|1848755|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 4, identity: 0.889

aatatttagagatggcgtagagtgttaaaagtttca	CRISPR spacer
aatatttagagatggtgtagagtgttaaaaattttg	Protospacer
***************.**************.***..

60. spacer 8.12|1848755|36|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN881738 (Escherichia phage slur17, complete genome) position: , mismatch: 4, identity: 0.889

aatatttagagatggcgtagagtgttaaaagtttca	CRISPR spacer
aatatttagagatggtgtagagtgttaaaaattttg	Protospacer
***************.**************.***..

61. spacer 3.2|1314793|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to HG531805 (Clostridium phage CDMH1 complete genome) position: , mismatch: 5, identity: 0.865

caaattgtctaatcctaattttttctttgcatcttct	CRISPR spacer
aaggtcatctaatcctaattttttctttgcatcttct	Protospacer
 *..*..******************************

62. spacer 1.1|146650|29|CP019857|CRISPRCasFinder matches to KY971610 (Pseudomonas phage PspYZU05, complete genome) position: , mismatch: 6, identity: 0.793

tgtaataagttaaagcaatatgaatcaac	CRISPR spacer
tacgataagttacagcaatacgaatcatc	Protospacer
*...******** *******.****** *

63. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to KU057941 (Clostridium phage CDSH1, complete genome) position: , mismatch: 6, identity: 0.838

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtacgattgttccatttttc---aaaatcgg	Protospacer
************.***************.   ****.

64. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NC_028905 (Clostridium phage phiCD111, complete genome) position: , mismatch: 6, identity: 0.838

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtacgattgttccatttttc---aaaatcgg	Protospacer
************.***************.   ****.

65. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to LN881738 (Escherichia phage slur17, complete genome) position: , mismatch: 6, identity: 0.838

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtacgattgttccatttttc---aaaatcgg	Protospacer
************.***************.   ****.

66. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NC_048665 (Clostridium phage phiCDHM14, complete genome) position: , mismatch: 7, identity: 0.811

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtgcgattgttccatttttc---aaaatcgg	Protospacer
***********..***************.   ****.

67. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to HG796225 (Clostridium phage phiCDHM13 complete genome) position: , mismatch: 7, identity: 0.811

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtgcgattgttccatttttc---aaaatcgg	Protospacer
***********..***************.   ****.

68. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to LN681538 (Clostridium phage phiCD481-1, complete genome) position: , mismatch: 7, identity: 0.811

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtgcgattgttccatttttc---aaaatcgg	Protospacer
***********..***************.   ****.

69. spacer 16.8|3315166|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to HG798901 (Clostridium phage phiCDHM11 complete genome) position: , mismatch: 7, identity: 0.811

aatcattttgtatgattgttccattttttttgaaaac---	CRISPR spacer
aatcattttgtgcgattgttccatttttc---aaaatcgg	Protospacer
***********..***************.   ****.

70. spacer 11.7|2817458|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MK448895 (Streptococcus phage Javan274, complete genome) position: , mismatch: 9, identity: 0.763

gctgataaagttattaaaagtaaaattgctgaaatact--	CRISPR spacer
tctgataaagttactaaaagtaaaactg--aaatcaatag	Protospacer
 ************.***********.**  .** .* *

71. spacer 11.7|2817458|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MK448769 (Streptococcus phage Javan471, complete genome) position: , mismatch: 9, identity: 0.763

gctgataaagttattaaaagtaaaattgctgaaatact--	CRISPR spacer
tctgataaagttactaaaagtaaaactg--aaatcaatag	Protospacer
 ************.***********.**  .** .* *

72. spacer 11.7|2817458|38|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MK448684 (Streptococcus phage Javan151, complete genome) position: , mismatch: 9, identity: 0.763

gctgataaagttattaaaagtaaaattgctgaaatact--	CRISPR spacer
tctgataaagttactaaaagtaaaactg--aaatcaatag	Protospacer
 ************.***********.**  .** .* *

73. spacer 16.11|3315363|36|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to MN693244 (Marine virus AFVG_25M166, complete genome) position: , mismatch: 9, identity: 0.75

tttttgaatgttgaagattttgttaatgcagggaaa	CRISPR spacer
tttttgaatgatgaagattttgctaatggtatttat	Protospacer
********** ***********.*****  .   *

74. spacer 2.2|1290723|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029750 (Staphylococcus aureus strain Smith plasmid pSS41, complete sequence) position: , mismatch: 10, identity: 0.73

tttatattaataaaatcatttacatttaaactcaaca-----	CRISPR spacer
tttatattaataaattcatttaaatt-----ccgtcagtttt	Protospacer
************** ******* ***     .*. **

75. spacer 3.2|1314793|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013332 (Fusobacterium hwasookii ChDC F174 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.73

caaattgtctaatcctaattttttctttgcatcttct	CRISPR spacer
ctaattgtctaatattaattttttctttatcagctgt	Protospacer
* *********** .*************..   .* *

76. spacer 4.1|1317663|38|CP019857|CRISPRCasFinder matches to LC168164 (Tenacibaculum phage pT24 DNA, complete genome) position: , mismatch: 10, identity: 0.737

cgtacagatagtattgcattagaggaaagtttaaaagc	CRISPR spacer
actgtaattattatggcattagaggaaagtttaaatac	Protospacer
  *..*. ** *** ******************** .*

77. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to NC_028958 (Clostridium phage phiCD146, complete genome) position: , mismatch: 10, identity: 0.73

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gctataataaataatattgtcgaatggtttaaacaaa	Protospacer
*  **********..***************. * .

78. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to LN881738 (Escherichia phage slur17, complete genome) position: , mismatch: 10, identity: 0.73

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gctataataaataatattgtcgaatggtttaaacaaa	Protospacer
*  **********..***************. * .

79. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to KU057941 (Clostridium phage CDSH1, complete genome) position: , mismatch: 10, identity: 0.73

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gctataataaataatattgtcgaatggtttaaacaaa	Protospacer
*  **********..***************. * .

80. spacer 8.13|1848820|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to HM568888 (Clostridium phage phiCD38-2, complete genome) position: , mismatch: 10, identity: 0.73

gaaataataaatagcattgtcgaatggtttgcaagcc	CRISPR spacer
gctataataaataatattgtcgaatggtttaaacaaa	Protospacer
*  **********..***************. * .

81. spacer 16.9|3315232|36|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to MK448421 (Streptococcus satellite phage Javan312, complete genome) position: , mismatch: 10, identity: 0.722

---ctctgtgactccatatttttttgcaatatataattc	CRISPR spacer
aaaatcc---actttatatttttttgcaatatataaacg	Protospacer
    **.   ***..********************* .

82. spacer 16.11|3315363|36|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NC_019782 (Lactobacillus phage AQ113, complete genome) position: , mismatch: 10, identity: 0.722

tttttgaatgttgaagattttgttaatgcagggaaa	CRISPR spacer
aattttaatgttgaagattttattaatgttgaaagt	Protospacer
  *** ***************.******. *..*.

83. spacer 11.2|2817126|37|CP019857|PILER-CR,CRISPRCasFinder,CRT matches to MN693317 (Marine virus AFVG_25M47, complete genome) position: , mismatch: 11, identity: 0.703

tctaatttaatagctttatttttagcaaaatacccaa	CRISPR spacer
tctaatttaccagctttatttttagctctgctttcag	Protospacer
********* .***************   .. ..**.

84. spacer 16.10|3315297|37|CP019857|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP023496 (Staphylococcus simulans strain FDAARGOS_383 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.703

catttgtaaatctttatgattatgtaatatattcata	CRISPR spacer
ttatcttaaatctttgggattatgtaatatatcttaa	Protospacer
.  *. *********. ***************..  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

284406 : 300583

Synechococcus_phage(23.08%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU85192.1\|284406_284919_-	nitroreductase	A0A1V0E011	Clostridioides_phage	3.5e-84	87.6
AXU85193.1\|285368_285845_+	phosphoribosylaminoimidazole carboxylase catalytic subunit	A0A2P0VNU7	Tetraselmis_virus	6.9e-26	45.8
AXU85194.1\|285850_286549_+	phosphoribosylaminoimidazole-succinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	1.5e-45	43.9
AXU85195.1\|286560_287928_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.6e-49	31.0
AXU85196.1\|287921_288998_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	2.2e-64	42.2
AXU85197.1\|288991_289585_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.3e-25	40.4
AXU85198.1\|289577_291110_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	2.3e-38	49.7
AXU85199.1\|291120_292371_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
AXU85200.1\|292395_296202_+	formylglycinamidine ribonucleotide synthetase	A6N228	Microbacterium_phage	1.0e-31	24.5
AXU85201.1\|296407_297280_+	dtdp-4-dehydrorhamnose reductase	H9NCE8	Sphingomonas_phage	2.3e-14	30.0
AXU85202.1\|297388_298258_+	glucose-1-phosphate thymidylyltransferase	I7I009	Enterobacteria_phage	4.7e-97	61.5
AXU85203.1\|298306_298864_+	dtdp-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.3e-47	53.6
AXU85204.1\|298901_299885_+	dtdp-glucose 4,6-dehydratase	A0A291LAD7	Escherichia_phage	1.9e-78	46.7
AXU85205.1\|299914_300583_+	transglycosylase	A0A0H3V0Q1	Geobacillus_virus	4.1e-24	46.9

DBSCAN-SWA_2

1282568 : 1338364

Clostridium_phage(81.48%)

tail,portal,protease,capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU86051.1\|1282568_1283816_+\|protease	protease	Q6DW11	Phage_TP	2.1e-58	37.6
AXU86052.1\|1283887_1285552_+	penicillin-binding protein	NA	NA	NA	NA
AXU86053.1\|1285955_1287473_-	site-specific recombinase	I3VYZ3	Thermoanaerobacterium_phage	2.4e-128	49.7
AXU86054.1\|1287597_1288419_-	lipoprotein	NA	NA	NA	NA
AXU86055.1\|1288609_1290037_+	cell surface protein	A0A2R2ZGK6	Clostridioides_phage	2.2e-75	43.4
AXU86056.1\|1290896_1291115_-	DNA-binding protein	J9QEC2	Clostridium_phage	3.0e-16	65.2
AXU86057.1\|1291871_1292048_+	hypothetical protein	NA	NA	NA	NA
AXU86058.1\|1292053_1292374_-	DNA-binding protein	A0A0A7RTW0	Clostridium_phage	7.7e-21	58.8
AXU86059.1\|1292531_1292756_+	hypothetical protein	A0A0A7S0N3	Clostridium_phage	1.0e-11	50.7
AXU86060.1\|1293057_1293384_+	prophage antirepressor	A0A2R2ZGJ4	Clostridioides_phage	6.0e-45	83.2
AXU86061.1\|1293493_1294309_+	phage anti-repressor	X5JAW6	Clostridium_phage	8.3e-96	69.6
AXU86062.1\|1294361_1294580_+	hypothetical protein	NA	NA	NA	NA
AXU86063.1\|1294694_1294856_+	hypothetical protein	A0A0A8WIF8	Clostridium_phage	1.8e-10	79.1
AXU86064.1\|1295058_1295301_+	hypothetical protein	A0A0A8WFK1	Clostridium_phage	6.0e-34	91.2
AXU86065.1\|1295431_1295749_+	putative replication initiation and membrane attachment	A0A090DCV4	Clostridium_phage	5.1e-25	58.5
AXU86066.1\|1295757_1296693_+	phage replication protein	B6SBX9	Clostridium_virus	5.3e-94	67.4
AXU86067.1\|1296676_1297366_+	ATPase AAA	Q0H276	Geobacillus_phage	5.0e-41	42.7
AXU86068.1\|1297370_1298024_+	RNA polymerase factor sigma-70	NA	NA	NA	NA
AXU86069.1\|1298101_1299019_+	hypothetical protein	NA	NA	NA	NA
AXU86070.1\|1299061_1299541_+	sigma-70 region 4 type 2	I2E8Y5	Clostridium_phage	5.9e-33	48.7
AXU86071.1\|1299688_1299892_+	hypothetical protein	NA	NA	NA	NA
AXU86072.1\|1299963_1300314_+	hypothetical protein	NA	NA	NA	NA
AXU86073.1\|1300379_1300592_+	hypothetical protein	NA	NA	NA	NA
AXU86074.1\|1301113_1302133_+	hypothetical protein	NA	NA	NA	NA
AXU86075.1\|1302214_1302640_+	phage-like protein	A0A090DCM3	Clostridium_phage	3.7e-63	90.6
AXU86076.1\|1302620_1303871_+\|terminase	phage terminase large subunit, pbsx family	A0A0A7RTE7	Clostridium_phage	1.5e-205	83.2
AXU86077.1\|1303875_1305315_+\|portal	phage portal protein	X5J9Z4	Clostridium_phage	4.7e-259	91.2
AXU86078.1\|1305304_1306702_+	phage protein	A0A0A8WJ84	Clostridium_phage	5.7e-262	96.1
AXU86079.1\|1306716_1306917_+	hypothetical protein	A0A0A8WJ56	Clostridium_phage	2.3e-31	100.0
AXU86080.1\|1306982_1307546_+	phage scaffold protein	A0A0A8WFU8	Clostridium_phage	2.5e-83	87.2
AXU86081.1\|1307557_1308457_+\|capsid	phage major capsid protein	A0A0A8WFI8	Clostridium_phage	2.8e-169	100.0
AXU86082.1\|1308456_1308690_+	hypothetical protein	A0A0A8WFD0	Clostridium_phage	1.4e-32	97.4
AXU86083.1\|1308699_1309101_+	hypothetical protein	X5JAJ0	Clostridium_phage	8.1e-68	97.0
AXU86084.1\|1309094_1309442_+	phage protein	X5JAV9	Clostridium_phage	1.1e-57	99.1
AXU86085.1\|1309441_1309732_+	phage protein	A0A0A8WFV8	Clostridium_phage	2.1e-46	100.0
AXU86086.1\|1309841_1310648_+	hypothetical protein	F8UBL7	Clostridium_phage	2.4e-47	48.0
AXU86087.1\|1310996_1311434_+	phage protein	X5JAB5	Clostridium_phage	4.8e-74	92.4
AXU86088.1\|1311417_1311603_+	hypothetical protein	A0A0A8WFD8	Clostridium_phage	1.4e-19	87.9
AXU86089.1\|1311603_1312914_+	phage protein	A0A0A8WIF0	Clostridium_phage	9.3e-230	92.0
AXU86090.1\|1312930_1313401_+	phage protein	A0A0A8WJ62	Clostridium_phage	5.5e-76	89.7
AXU86091.1\|1313471_1313912_+	phage protein	X5JAB6	Clostridium_phage	1.0e-47	63.7
AXU86092.1\|1313986_1314106_+	phage protein	NA	NA	NA	NA
AXU86093.1\|1314254_1314416_+	hypothetical protein	A0A0A8WFE0	Clostridium_phage	2.0e-06	76.5
AXU86094.1\|1315125_1315323_+	hypothetical protein	A0A090EUD7	Clostridium_phage	1.3e-10	60.0
AXU86095.1\|1315297_1315663_-	hypothetical protein	NA	NA	NA	NA
AXU86096.1\|1316096_1316339_+	hypothetical protein	X5JAJ2	Clostridium_phage	3.2e-11	56.9
AXU86097.1\|1316459_1317326_+	prophage antirepressor-related protein	X5JAW1	Clostridium_phage	1.4e-104	65.4
AXU86098.1\|1317380_1317536_+	hypothetical protein	NA	NA	NA	NA
AXU86099.1\|1318126_1318651_+	hypothetical protein	NA	NA	NA	NA
AXU86100.1\|1319134_1319956_+	prophage antirepressor-related protein	X5JAW1	Clostridium_phage	3.2e-87	73.3
AXU86101.1\|1320018_1320195_+	hypothetical protein	NA	NA	NA	NA
AXU86102.1\|1320560_1321334_+	hypothetical protein	X5JB37	Clostridium_phage	1.0e-34	36.7
AXU86103.1\|1321400_1323689_+\|tail	phage tail tape measure protein	A0A0A8WJT6	Clostridium_phage	2.9e-279	78.1
AXU86104.1\|1323704_1324394_+	phage cell wall hydrolase	X5J9Z8	Clostridium_phage	3.7e-121	96.5
AXU86105.1\|1324386_1326279_+	phage cell wall hydrolase	A3QSB3	Clostridium_virus	0.0e+00	89.8
AXU86106.1\|1326292_1326553_+	phage protein	A0A0A8WJ65	Clostridium_phage	4.9e-34	87.2
AXU86107.1\|1326557_1326977_+	phage protein	X5JB38	Clostridium_phage	1.1e-72	98.6
AXU86108.1\|1326977_1328027_+	phage protein	A0A0A8WFK0	Clostridium_phage	3.6e-184	94.6
AXU86109.1\|1328019_1328637_+	phage protein	A0A0A8WFE8	Clostridium_phage	1.0e-114	98.0
AXU86110.1\|1328648_1329425_+\|tail	phage tail fiber protein	X5JAJ4	Clostridium_phage	2.5e-97	74.7
AXU86111.1\|1329440_1330901_+	hypothetical protein	J9QE87	Clostridium_phage	1.7e-99	54.1
AXU86112.1\|1330916_1331264_+	hypothetical protein	A3QSB8	Clostridium_virus	2.2e-45	81.7
AXU86113.1\|1331275_1331446_+	hypothetical protein	A0A0A8WEI9	Clostridium_phage	4.5e-12	68.0
AXU86114.1\|1331581_1333357_+	Glycine rich protein	A0A0A8WI57	Clostridium_phage	5.1e-130	60.9
AXU86115.1\|1333460_1333751_+	hypothetical protein	A0A0A8WIF5	Clostridium_phage	2.0e-44	96.9
AXU86116.1\|1333754_1334012_+	phage membrane protein	A0A0K2SUI8	Clostridium_phage	1.6e-37	85.9
AXU86117.1\|1334011_1334818_+	phage-related cell wall hydrolase	A0A0A8WE15	Clostridium_phage	9.0e-151	95.1
AXU86118.1\|1335070_1336330_+	ABC transporter	C7BGE8	Burkholderia_phage	3.6e-37	27.3
AXU86119.1\|1336326_1337085_+	hypothetical protein	NA	NA	NA	NA
AXU86120.1\|1337157_1337646_-	hypothetical protein	NA	NA	NA	NA
AXU86121.1\|1337980_1338364_-	hypothetical protein	A0A1V0E007	Clostridioides_phage	2.3e-43	73.2

DBSCAN-SWA_3

1466452 : 1484281

Clostridium_phage(52.63%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU86241.1\|1466452_1466653_+	cold shock protein	A0A1W6JNX5	Morganella_phage	2.7e-16	66.2
AXU86242.1\|1467073_1467502_+	regulatory protein	NA	NA	NA	NA
AXU86243.1\|1467644_1468400_-	peptidyl-prolyl isomerase	NA	NA	NA	NA
AXU86244.1\|1468520_1468937_-	hypothetical protein	NA	NA	NA	NA
AXU86245.1\|1469100_1469607_-	phage protein	A0A0A8WEK1	Clostridium_phage	4.0e-56	67.1
AXU86246.1\|1469688_1470009_-	phage repressor	A0A0A8WE28	Clostridium_phage	3.7e-23	54.5
AXU86247.1\|1470177_1470375_+	phage regulatory protein	NA	NA	NA	NA
AXU86248.1\|1470479_1470920_+	DNA-binding protein	A0A090EUN5	Clostridium_phage	6.0e-32	51.4
AXU86249.1\|1471168_1471612_+	hypothetical protein	A0A1V0DZX9	Clostridioides_phage	1.3e-18	35.4
AXU86250.1\|1471616_1472681_+	phage-like element pbsx protein xkdK	A0A1V0DZX4	Clostridioides_phage	1.6e-99	53.7
AXU86251.1\|1472694_1473123_+	phage-like element pbsx protein XkdM	A0A1V0DZX1	Clostridioides_phage	4.8e-34	51.8
AXU86252.1\|1473236_1473683_+	Phage XkdN-like protein	A0A0A7RTP2	Clostridium_phage	1.1e-12	36.4
AXU86253.1\|1473876_1476207_+	phage protein	A0A1V0DZX3	Clostridioides_phage	1.7e-16	59.7
AXU86254.1\|1476206_1476629_+	phage-like element pbsx protein xkdP	A0A1V0DZX0	Clostridioides_phage	9.4e-51	65.0
AXU86255.1\|1476897_1478415_+	phage cell wall hydrolase	A0A0A8WF62	Clostridium_phage	2.5e-247	83.4
AXU86256.1\|1478428_1478755_+	hypothetical protein	J9QE86	Clostridium_phage	1.3e-31	57.4
AXU86257.1\|1478754_1479186_+	phage protein	A0A0K2SUB3	Clostridium_phage	9.3e-62	82.3
AXU86258.1\|1479178_1480228_+	phage protein	J9QDY7	Clostridium_phage	1.2e-131	67.4
AXU86259.1\|1480227_1480845_+	phage protein	J9QD29	Clostridium_phage	4.1e-71	63.9
AXU86260.1\|1480846_1481659_+\|tail	phage tail fiber protein	A0A0A8WES5	Clostridium_phage	1.6e-75	62.6
AXU86261.1\|1481814_1482270_-	hypothetical protein	NA	NA	NA	NA
AXU86262.1\|1482497_1482917_-	phage regulatory protein	S5MUV6	Brevibacillus_phage	5.4e-06	37.2
AXU86263.1\|1483215_1483425_+	phage regulatory protein	Q5YAA3	Bacillus_phage	5.9e-06	47.2
AXU86264.1\|1483456_1483666_+	hypothetical protein	NA	NA	NA	NA
AXU86265.1\|1483882_1484281_-	phage regulatory protein	A0A1L2JY18	Aeribacillus_phage	2.7e-07	29.7

DBSCAN-SWA_4

1566252 : 1575979

Pandoravirus(37.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU86334.1\|1566252_1566837_+	para-aminobenzoate synthase glutamine amidotransferase component II	A0A0P0IKJ1	Acinetobacter_phage	1.4e-57	52.6
AXU86335.1\|1566838_1568188_+	para-aminobenzoate synthase component I	S4VNU7	Pandoravirus	2.2e-37	41.2
AXU86336.1\|1568177_1568921_+	aminodeoxychorismate lyase	NA	NA	NA	NA
AXU86337.1\|1568954_1569656_+	hypothetical protein	NA	NA	NA	NA
AXU86338.1\|1569681_1570254_+	GTP cyclohydrolase I	E7DN69	Pneumococcus_phage	3.0e-44	51.6
AXU86339.1\|1570317_1571109_+	dihydropteroate synthase	A0A0B5J4J5	Pandoravirus	3.7e-24	28.8
AXU86340.1\|1571119_1571485_+	dihydroneopterin aldolase	NA	NA	NA	NA
AXU86341.1\|1571477_1571984_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase	S4VNV0	Pandoravirus	2.7e-12	35.2
AXU86342.1\|1571964_1572750_+	chorismate biosynthesis-like protein	E3T537	Cafeteria_roenbergensis_virus	1.7e-13	27.9
AXU86343.1\|1573004_1574795_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.2e-51	32.6
AXU86344.1\|1574812_1575979_+	RNA polymerase sigma factor (sigma-43)	M4SMP8	Cyanophage	9.6e-37	36.8

DBSCAN-SWA_5

1710909 : 1725231

Streptococcus_phage(91.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU86465.1\|1710909_1711821_-	conjugative transposon protein	A0A1S5SF22	Streptococcus_phage	4.1e-83	52.1
AXU86466.1\|1711837_1712845_-	cell wall hydrolase	A0A1S5SEZ8	Streptococcus_phage	3.1e-132	68.8
AXU86467.1\|1712841_1715052_-	conjugative transposon protein	A0A1S5SF30	Streptococcus_phage	1.6e-186	59.9
AXU86468.1\|1715051_1717502_-	conjugative transposon protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.1
AXU86469.1\|1717479_1717878_-	conjugative transposon protein	A0A1S5SEX7	Streptococcus_phage	4.1e-48	73.0
AXU86470.1\|1717987_1718491_-	conjugative transposon protein	A0A1S5SF25	Streptococcus_phage	7.5e-55	60.8
AXU86471.1\|1718508_1718991_-	conjugative tansposon protein	NA	NA	NA	NA
AXU86472.1\|1718930_1719227_-	hypothetical protein	NA	NA	NA	NA
AXU86473.1\|1719327_1719801_-	N-acetyltransferase GCN5	NA	NA	NA	NA
AXU86474.1\|1719877_1720099_-	conjugative transposon protein	A0A1S5SEY0	Streptococcus_phage	9.0e-29	87.7
AXU86475.1\|1720099_1720234_-	conjugative transposon protein	NA	NA	NA	NA
AXU86476.1\|1720245_1721442_-	conjugative transposon replication initiation factor	A0A1S5SEX3	Streptococcus_phage	4.3e-149	62.8
AXU86477.1\|1721686_1722103_-	hypothetical protein	NA	NA	NA	NA
AXU86478.1\|1722106_1723489_-	conjugative transposon FtsK/SpoIIIE-like protein	A0A1S5SFB5	Streptococcus_phage	2.0e-174	66.7
AXU86479.1\|1723589_1723916_-	hypothetical protein	NA	NA	NA	NA
AXU86480.1\|1723931_1724339_-	DNA-binding protein	A0A0A7AQV8	Bacillus_phage	2.6e-05	42.3
AXU86481.1\|1724505_1724889_-	conjugative transposon protein	A0A1S5SF96	Streptococcus_phage	2.3e-32	55.9
AXU86482.1\|1724904_1725231_-	conjugative transposon protein	A0A1S5SF38	Streptococcus_phage	2.0e-24	51.5

DBSCAN-SWA_6

2007149 : 2027757

Streptococcus_phage(84.62%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU86739.1\|2007149_2007563_+	conjugative transposon protein	A0A1S5SF96	Streptococcus_phage	9.6e-40	76.4
AXU86740.1\|2007643_2008102_+	glyoxalase/bleomycin resistance protein/dioxygenase	NA	NA	NA	NA
AXU86741.1\|2008165_2008579_+	hypothetical protein	NA	NA	NA	NA
AXU86742.1\|2008633_2009236_+	hydrolase	NA	NA	NA	NA
AXU86743.1\|2009296_2009839_+	hypothetical protein	NA	NA	NA	NA
AXU86744.1\|2009835_2010402_+	hypothetical protein	NA	NA	NA	NA
AXU86745.1\|2010512_2011907_+	conjugative transposon FtsK/SpoIIIE-like protein	A0A1S5SFB5	Streptococcus_phage	8.2e-176	65.5
AXU86746.1\|2012174_2013287_+	conjugative transposon replication initiation factor	A0A1S5SEX3	Streptococcus_phage	6.4e-139	63.7
AXU86747.1\|2013438_2013660_+	conjugative transposon protein	A0A1S5SEY0	Streptococcus_phage	4.5e-28	84.9
AXU86748.1\|2013958_2014456_+	conjugative transposon protein	A0A1S5SF25	Streptococcus_phage	1.0e-27	42.7
AXU86749.1\|2014471_2014975_+	conjugative transposon protein	A0A1S5SF25	Streptococcus_phage	1.2e-52	57.9
AXU86750.1\|2015464_2017915_+	conjugative transposon protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.3
AXU86751.1\|2017915_2020087_+	conjugative transposon protein	A0A1S5SF30	Streptococcus_phage	8.8e-177	58.1
AXU86752.1\|2020083_2020515_+	cell wall hydrolase	A0A1S5SEZ8	Streptococcus_phage	1.1e-35	60.4
AXU86753.1\|2021282_2023058_+	group II intron reverse transcriptase/mutarase	A0A0U4J920	Pseudomonas_phage	1.8e-34	27.9
AXU86754.1\|2023258_2023750_+	cell wall hydrolase	A0A1S5SEZ8	Streptococcus_phage	1.1e-77	78.5
AXU86755.1\|2023766_2024669_+	conjugative transposon protein	A0A1S5SF22	Streptococcus_phage	6.9e-83	51.8
AXU86756.1\|2024842_2025211_+	hypothetical protein	NA	NA	NA	NA
AXU86757.1\|2025366_2025957_+	transcriptional regulator	NA	NA	NA	NA
AXU86758.1\|2025984_2027757_+	ABC transporter	W8CYL7	Bacillus_phage	3.7e-40	28.7

DBSCAN-SWA_7

2239728 : 2259923

Streptococcus_phage(100.0%)

integrase

attL 2230282:2230301|attR 2252638:2252657

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2230282:2230301	attL	NA	NA	NA	NA
AXU86956.1\|2239728_2240997_-\|integrase	integrase	A0A1S5SEW7	Streptococcus_phage	1.5e-155	67.3
AXU86957.1\|2240996_2241200_-	excisionase	A0A1S5SF07	Streptococcus_phage	2.5e-25	82.1
AXU86958.1\|2241574_2241814_-	conjugative transposon excisionase	NA	NA	NA	NA
AXU86959.1\|2241806_2242487_-	conjugative transposon protein	A0A1S5SEW0	Streptococcus_phage	3.9e-22	43.1
AXU86960.1\|2242514_2242739_-	hypothetical protein	NA	NA	NA	NA
AXU86961.1\|2242770_2243196_-	hypothetical protein	NA	NA	NA	NA
AXU86962.1\|2243594_2243858_+	plasmid protein	A0A1X9I6D5	Streptococcus_phage	4.4e-22	83.1
AXU86963.1\|2244086_2244824_+	rRNA adenine N-6-methyltransferase	E4ZFQ0	Streptococcus_phage	7.0e-134	99.2
AXU86964.1\|2245431_2245848_-	hypothetical protein	NA	NA	NA	NA
AXU86965.1\|2245844_2246048_-	XRE family transcriptional regulator	NA	NA	NA	NA
AXU86966.1\|2246148_2247060_-	conjugative transposon protein	A0A1S5SF22	Streptococcus_phage	2.2e-84	53.6
AXU86967.1\|2247077_2248085_-	cell wall hydrolase	A0A1S5SEZ8	Streptococcus_phage	6.4e-130	67.6
AXU86968.1\|2248081_2250286_-	conjugative transposon protein	A0A1S5SF30	Streptococcus_phage	1.6e-181	51.1
AXU86969.1\|2250285_2252736_-	conjugative transposon protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.4
2252638:2252657	attR	NA	NA	NA	NA
AXU86970.1\|2252713_2253112_-	conjugative transposon protein	A0A1S5SEX7	Streptococcus_phage	4.1e-48	73.0
AXU86971.1\|2253228_2253732_-	conjugative transposon protein	A0A1S5SF25	Streptococcus_phage	7.5e-55	60.8
AXU86972.1\|2253749_2254253_-	conjugative tansposon protein	NA	NA	NA	NA
AXU86973.1\|2254577_2255198_-	hypothetical protein	NA	NA	NA	NA
AXU86974.1\|2255287_2255509_-	conjugative transposon protein	A0A1S5SEY0	Streptococcus_phage	9.0e-29	87.7
AXU86975.1\|2255509_2255644_-	conjugative transposon protein	NA	NA	NA	NA
AXU86976.1\|2255656_2256853_-	conjugative transposon replication initiation factor	A0A1S5SEX3	Streptococcus_phage	4.7e-148	62.3
AXU86977.1\|2257036_2258431_-	conjugative transposon FtsK/SpoIIIE-like protein	A0A1S5SFB5	Streptococcus_phage	2.3e-178	66.4
AXU86978.1\|2258514_2259117_-	DNA-binding SAP domain-containing protein	NA	NA	NA	NA
AXU86979.1\|2259197_2259581_-	conjugative transposon protein	A0A1S5SF96	Streptococcus_phage	4.4e-31	55.1
AXU86980.1\|2259596_2259923_-	conjugative transposon protein	A0A1S5SF38	Streptococcus_phage	1.1e-25	52.4

DBSCAN-SWA_8

2568573 : 2574852

Clostridium_phage(71.43%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU87245.1\|2568573_2569026_-	prophage antirepressor-related protein	X5JAW1	Clostridium_phage	1.5e-70	89.9
AXU87246.1\|2569022_2569388_-	phage-related regulatory protein	A0A2R2ZGW3	Clostridioides_phage	1.2e-38	66.7
AXU87247.1\|2569507_2569660_-	hypothetical protein	X5JAJ2	Clostridium_phage	1.6e-05	59.2
AXU87248.1\|2570642_2571527_-	hypothetical protein	NA	NA	NA	NA
AXU87249.1\|2571720_2571873_-	hypothetical protein	J9QED5	Clostridium_phage	9.6e-06	52.0
AXU87250.1\|2572146_2572479_-	hypothetical protein	NA	NA	NA	NA
AXU87251.1\|2572505_2572760_-	hypothetical protein	NA	NA	NA	NA
AXU87252.1\|2573191_2573485_-\|transposase	transposase-like protein B	A0A0H3UZC2	Geobacillus_virus	3.6e-33	62.8
AXU87253.1\|2574181_2574373_-	repressor	A0A0A8WFF9	Clostridium_phage	6.4e-15	70.5
AXU87254.1\|2574477_2574852_-	regulatory protein	A0A0A8WJU1	Clostridium_phage	7.1e-50	88.0

DBSCAN-SWA_9

3127211 : 3136164

Catovirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU87725.1\|3127211_3129125_-	capsular polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	1.1e-26	29.8
AXU87726.1\|3129208_3130300_-	capsular polysaccharide biosynthesis glycosyl transferase	A0A1V0SL50	Klosneuvirus	1.8e-16	26.2
AXU87727.1\|3130305_3131601_-	UDP-glucose 6-dehydrogenase	A0A127AXI2	Bacillus_phage	2.9e-90	43.6
AXU87728.1\|3131626_3132379_-	teichuronic acid biosynthesis glycosyl transferase	A0A1V0SAH6	Catovirus	4.6e-16	40.5
AXU87729.1\|3132426_3133335_-	beta-glycosyltransferase	NA	NA	NA	NA
AXU87730.1\|3133356_3134106_-	teichuronic acid biosynthesis glycosyl transferase	A0A1V0SAH6	Catovirus	1.2e-16	38.8
AXU87731.1\|3134134_3135310_-	minor teichoic acid biosynthesis protein	NA	NA	NA	NA
AXU87732.1\|3135324_3136164_-	glycosyl transferase	A0A2P1ELT8	Moumouvirus	7.0e-05	26.3

DBSCAN-SWA_10

3495822 : 3519902

Streptococcus_phage(86.96%)

integrase

attL 3491246:3491261|attR 3520554:3520569

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3491246:3491261	attL	NA	NA	NA	NA
AXU88017.1\|3495822_3496149_+	conjugative transposon protein	A0A1S5SF38	Streptococcus_phage	2.0e-24	51.5
AXU88018.1\|3496164_3496548_+	conjugative transposon protein	A0A1S5SF96	Streptococcus_phage	5.2e-32	57.6
AXU88019.1\|3496715_3497123_+	DNA-binding protein	A0A0A7AQV8	Bacillus_phage	1.2e-05	42.3
AXU88020.1\|3497138_3497465_+	hypothetical protein	NA	NA	NA	NA
AXU88021.1\|3497565_3498960_+	conjugative transposon FtsK/SpoIIIE-like protein	A0A1S5SFB5	Streptococcus_phage	1.9e-177	66.2
AXU88022.1\|3499143_3500340_+	conjugative transposon replication initiation factor	A0A1S5SEX3	Streptococcus_phage	7.3e-149	62.5
AXU88023.1\|3500352_3500487_+	conjugative transposon protein	NA	NA	NA	NA
AXU88024.1\|3500487_3500709_+	conjugative transposon protein	A0A1S5SEY0	Streptococcus_phage	9.0e-29	87.7
AXU88025.1\|3500912_3501689_+	Xre family transcriptional regulator	W6LMS6	Streptococcus_phage	4.9e-05	46.6
AXU88026.1\|3501773_3502070_+	hypothetical protein	NA	NA	NA	NA
AXU88027.1\|3502009_3502492_+	conjugative tansposon protein	NA	NA	NA	NA
AXU88028.1\|3502509_3503013_+	conjugative transposon protein	A0A1S5SF25	Streptococcus_phage	3.4e-55	61.4
AXU88029.1\|3503130_3503529_+	conjugative transposon protein	A0A1S5SEX7	Streptococcus_phage	3.2e-48	73.0
AXU88030.1\|3503506_3505957_+	conjugative transposon protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.1
AXU88031.1\|3505956_3508152_+	conjugative transposon protein	A0A1S5SF30	Streptococcus_phage	4.4e-176	68.6
AXU88032.1\|3508148_3509156_+	cell wall hydrolase	A0A1S5SEZ8	Streptococcus_phage	3.0e-135	69.9
AXU88033.1\|3509171_3510083_+	conjugative transposon protein	A0A1S5SF22	Streptococcus_phage	1.2e-82	52.8
AXU88034.1\|3510203_3510581_+	GntR family transcriptional regulator	NA	NA	NA	NA
AXU88035.1\|3510581_3511445_+	transporter	A0A2H4PQG7	Staphylococcus_phage	3.3e-18	30.2
AXU88036.1\|3511441_3512086_+	ABC transporter permease	NA	NA	NA	NA
AXU88037.1\|3512098_3512290_+	hypothetical protein	NA	NA	NA	NA
AXU88038.1\|3512494_3512683_+	conjugative transposon protein	D0R0F6	Streptococcus_phage	8.2e-15	57.9
AXU88039.1\|3512790_3513150_-	transposon-related DNA-binding protein	A0A1S5SFA6	Streptococcus_phage	2.3e-21	45.0
AXU88040.1\|3513342_3513552_+	Omega Transcriptional Repressor	A0A1X9I6D5	Streptococcus_phage	6.3e-32	100.0
AXU88041.1\|3513568_3513841_+	Antitoxin epsilon	A0A1X9I6E5	Streptococcus_phage	5.0e-05	100.0
AXU88042.1\|3513842_3514001_+	UDP-N-acetylglucosamine kinase	NA	NA	NA	NA
AXU88043.1\|3514052_3514472_+	plasmid protein	NA	NA	NA	NA
AXU88044.1\|3514518_3515256_+	rRNA adenine N-6-methyltransferase	E4ZFQ0	Streptococcus_phage	1.4e-134	99.6
AXU88045.1\|3515260_3515392_+	hypothetical protein	E4ZFP9	Streptococcus_phage	8.2e-14	90.7
AXU88046.1\|3515788_3516667_+	plasmid replication protein	A0A1X9I765	Streptococcus_phage	1.2e-148	97.8
AXU88047.1\|3517114_3517531_+	conjugative transposon protein	A0A1S5SEW0	Streptococcus_phage	3.8e-20	38.0
AXU88048.1\|3517537_3517786_+	conjugative transposon excisionase	NA	NA	NA	NA
AXU88049.1\|3518180_3518438_+	excisionase	NA	NA	NA	NA
AXU88050.1\|3518456_3519902_+\|integrase	integrase	A0A0A8WIF9	Clostridium_phage	3.5e-12	23.9
3520554:3520569	attR	NA	NA	NA	NA

DBSCAN-SWA_11

3758994 : 3819145

Agrobacterium_phage(15.38%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU88243.1\|3758994_3760074_-\|protease	protease	A0A1B1IT49	uncultured_Mediterranean_phage	3.3e-15	25.7
AXU88244.1\|3760229_3761579_-	glucose-6-phosphate isomerase	NA	NA	NA	NA
AXU88245.1\|3761843_3763472_-	sodium-dependent phosphate transporter	NA	NA	NA	NA
AXU88246.1\|3763595_3765200_-	FAD-dependent dehydrogenase	NA	NA	NA	NA
AXU88247.1\|3765247_3765565_-	hypothetical protein	NA	NA	NA	NA
AXU88248.1\|3765569_3765935_-	hypothetical protein	NA	NA	NA	NA
AXU88249.1\|3766015_3767053_-	protein translocase	NA	NA	NA	NA
AXU88250.1\|3767305_3767890_-	hypothetical protein	NA	NA	NA	NA
AXU88251.1\|3767904_3768348_-	hypothetical protein	NA	NA	NA	NA
AXU88252.1\|3768348_3769221_-	fimbrial assembly protein	NA	NA	NA	NA
AXU88253.1\|3769273_3769633_-	type IV pilin	NA	NA	NA	NA
AXU88254.1\|3769686_3770772_-	type IV pilus-assembly protein	NA	NA	NA	NA
AXU88255.1\|3770942_3772292_-	type IV pilus-assembly protein	NA	NA	NA	NA
AXU88256.1\|3772314_3772995_-	membrane protein	NA	NA	NA	NA
AXU88257.1\|3773385_3774465_-	ATP/GTP-binding protein	NA	NA	NA	NA
AXU88258.1\|3775042_3776413_+	transporter	NA	NA	NA	NA
AXU88259.1\|3776677_3777289_-	ribosome biogenesis GTP-binding protein YsxC	NA	NA	NA	NA
AXU88260.1\|3777278_3779642_-\|protease	ATP-dependent protease La	A0A0R6PGP8	Moraxella_phage	4.0e-175	44.4
AXU88261.1\|3779821_3780334_+	chromate transport protein	NA	NA	NA	NA
AXU88262.1\|3780321_3780849_+	chromate transport protein	NA	NA	NA	NA
AXU88263.1\|3780919_3782170_-\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	6.1e-146	63.1
AXU88264.1\|3782188_3782773_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	2.5e-57	58.8
AXU88265.1\|3782922_3784209_-	trigger factor	NA	NA	NA	NA
AXU88266.1\|3784402_3784873_-	phosphoesterase	NA	NA	NA	NA
AXU88267.1\|3784872_3786222_-	ribonuclease PH	NA	NA	NA	NA
AXU88268.1\|3786381_3788406_-	DNA ligase	A0A0K2QQN8	Ralstonia_phage	3.8e-113	37.6
AXU88269.1\|3788591_3789530_-	D-isomer specific 2-hydroxyacid dehydrogenase	NA	NA	NA	NA
AXU88270.1\|3789631_3790054_-	hypothetical protein	NA	NA	NA	NA
AXU88271.1\|3790241_3791525_+	transporter	NA	NA	NA	NA
AXU88272.1\|3791602_3792118_-	electron transport protein	NA	NA	NA	NA
AXU88273.1\|3792117_3793494_-	hydrogenase	NA	NA	NA	NA
AXU88274.1\|3793518_3794070_-	electron transport protein	NA	NA	NA	NA
AXU88275.1\|3794106_3794322_-	hypothetical protein	NA	NA	NA	NA
AXU88276.1\|3794290_3795124_-	formate dehydrogenase accessory protein	NA	NA	NA	NA
AXU88277.1\|3797567_3798626_-	ABC transporter permease	NA	NA	NA	NA
AXU88278.1\|3798836_3799496_-	two-component response regulator	W8CYM9	Bacillus_phage	4.2e-29	33.6
AXU88279.1\|3799806_3800436_+	hypothetical protein	NA	NA	NA	NA
AXU88280.1\|3800462_3801101_+	hypothetical protein	NA	NA	NA	NA
AXU88281.1\|3801196_3801985_-	ABC-2 family transporter protein	NA	NA	NA	NA
AXU88282.1\|3801985_3802858_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.0e-27	34.8
AXU88283.1\|3804145_3804520_-	hypothetical protein	NA	NA	NA	NA
AXU88284.1\|3805030_3805354_-	accessory genes regulator	X5JB40	Clostridium_phage	1.9e-11	35.8
AXU88285.1\|3805412_3805553_-	autoinducer prepeptide	NA	NA	NA	NA
AXU88286.1\|3805564_3806881_-	sensor histidine kinase VirS	X5JAC0	Clostridium_phage	3.4e-54	33.2
AXU88287.1\|3806874_3807585_-	LytR family DNA-binding response regulator	A0A2R2ZGH8	Clostridioides_phage	2.2e-28	36.2
AXU88288.1\|3808023_3808599_-	hypothetical protein	NA	NA	NA	NA
AXU88289.1\|3808891_3809170_-	Mor transcription activator domain-containing protein	NA	NA	NA	NA
AXU88290.1\|3809478_3810240_-	iron-sulfur cluster-binding protein	NA	NA	NA	NA
AXU88291.1\|3810408_3812460_-	exosporium glycoprotein	A0A285PXU9	Cedratvirus	2.2e-52	67.9
AXU88292.1\|3812538_3813615_-	glycosyl transferase	A0A1V0SAJ8	Catovirus	1.3e-16	25.3
AXU88293.1\|3813926_3814511_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	3.6e-48	51.3
AXU88294.1\|3814507_3814990_-	AraC family transcription regulator	NA	NA	NA	NA
AXU88295.1\|3815188_3816604_-	GntR family transcriptional regulator	NA	NA	NA	NA
AXU88296.1\|3816718_3817387_+	B3/4 domain protein	NA	NA	NA	NA
AXU88297.1\|3817562_3818081_-	nitroreductase	NA	NA	NA	NA
AXU88298.1\|3818232_3818556_+	transcriptional regulator	NA	NA	NA	NA
AXU88299.1\|3818560_3819145_-\|protease	protease	NA	NA	NA	NA

DBSCAN-SWA_12

3892969 : 3915130

Streptococcus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXU88357.1\|3892969_3895735_-	magnesium transporting ATPase, P-type	M1HJQ2	Paramecium_bursaria_Chlorella_virus	5.8e-48	25.6
AXU88358.1\|3895900_3896212_-	hypothetical protein	NA	NA	NA	NA
AXU88359.1\|3896458_3897136_-	magnesium transporting ATPase protein C	G3MA03	Bacillus_virus	3.3e-13	36.0
AXU88360.1\|3897273_3897777_-	transcriptional regulator	NA	NA	NA	NA
AXU88361.1\|3897792_3900456_-	magnesium transporting ATPase, P-type 1	M1HBF8	Paramecium_bursaria_Chlorella_virus	1.5e-37	24.8
AXU88362.1\|3901242_3902145_-	conjugative transposon protein	A0A1S5SF22	Streptococcus_phage	8.4e-81	52.3
AXU88363.1\|3902160_3903174_-	cell wall hydrolase	A0A1S5SEZ8	Streptococcus_phage	3.7e-133	69.3
AXU88364.1\|3903170_3905375_-	conjugative transposon protein	A0A1S5SF30	Streptococcus_phage	9.3e-182	51.4
AXU88365.1\|3905374_3907825_-	conjugative transposon protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.2
AXU88366.1\|3908318_3908822_-	conjugative transposon protein	A0A1S5SF25	Streptococcus_phage	4.4e-55	60.2
AXU88367.1\|3908839_3909343_-	conjugative tansposon protein	NA	NA	NA	NA
AXU88368.1\|3909640_3910282_-	chloramphenicol o-acetyltransferase	G3CFL0	Escherichia_phage	1.2e-33	33.3
AXU88369.1\|3910489_3910711_-	conjugative transposon protein	A0A1S5SEY0	Streptococcus_phage	9.0e-29	87.7
AXU88370.1\|3910711_3910846_-	conjugative transposon protein	NA	NA	NA	NA
AXU88371.1\|3910858_3912055_-	conjugative transposon replication initiation factor	A0A1S5SEX3	Streptococcus_phage	1.1e-147	62.3
AXU88372.1\|3912238_3913633_-	conjugative transposon FtsK/SpoIIIE-like protein	A0A1S5SFB5	Streptococcus_phage	4.6e-179	66.6
AXU88373.1\|3913699_3914314_-	hypothetical protein	NA	NA	NA	NA
AXU88374.1\|3914404_3914788_-	conjugative transposon protein	A0A1S5SF96	Streptococcus_phage	2.3e-32	55.9
AXU88375.1\|3914803_3915130_-	conjugative transposon protein	A0A1S5SF38	Streptococcus_phage	1.4e-25	53.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP019857

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection