CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP022720	Staphylococcus aureus strain 135 chromosome, complete genome	4 crisprs	cas3,DEDDh,DinG,csa3,WYL	3	3	8	0
CP022721	Staphylococcus aureus strain 135 plasmid pPS00087.1A.1, complete sequence	0 crisprs	csa3	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP022720_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022720_1

775215-775295

Unclear

Consensus_repeat	Method
TTCTTTATGTTGGGGCCCCGCCAACT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of CP022720_1

>merge|CP022720|1|775215-775295|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACTTGCATTGTTTGTAGAATTTCTTTTCGAAATTCTTTATGTTGGGGCCCCGCCAACT

>CP022720|1|1|775215-775295|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACT	TGCATTGTTTGTAGAATTTCTTTTCGAAA
TTCTTTATGTTGGGGCCCCGCCAACT

Protein	Signature genes	Signature genes Name	Protein_function
CP022720.1\|AXJ30161.1\|776469_777309_+\|Prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
CP022720.1\|AXJ30159.1\|772078_774925_+\|UvrABC-system-protein-A	unknown	unknown	gnl\|CDD\|234734
CP022720.1\|AXJ30156.1\|768933_769584_+\|5'-deoxynucleotidase-YfbR	unknown	unknown	gnl\|CDD\|378993
CP022720.1\|AXJ30160.1\|775531_776464_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
CP022720.1\|AXJ30162.1\|777316_777802_+\|Maltose-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100053
CP022720.1\|AXJ30151.1\|761834_762509_+\|DNA-utilization-protein-GntX	unknown	unknown	gnl\|CDD\|223970
CP022720.1\|AXJ30169.1\|785436_786339_-\|Epimerase-family-protein	unknown	unknown	gnl\|CDD\|224015
CP022720.1\|AXJ30150.1\|760759_761842_+\|primosome-assembly-protein-PriA	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|226583
CP022720.1\|AXJ30167.1\|783089_784034_+\|Putative-sporulation-transcription-regulator-WhiA	unknown	unknown	gnl\|CDD\|273194
CP022720.1\|AXJ30155.1\|767920_768760_+\|Secretory-antigen-SsaA-precursor	unknown	unknown	gnl\|CDD\|226451
CP022720.1\|AXJ30158.1\|770085_772071_+\|UvrABC-system-protein-B	unknown	unknown	gnl\|CDD\|235395
CP022720.1\|AXJ30154.1\|766519_767512_+\|Peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
CP022720.1\|AXJ30164.1\|779315_780251_+\|Thioredoxin-reductase	unknown	unknown	gnl\|CDD\|273540
CP022720.1\|AXJ30168.1\|784606_785194_+\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
CP022720.1\|AXJ30165.1\|781075_781987_+\|glmZ(sRNA)-inactivating-NTPase	unknown	unknown	gnl\|CDD\|224574
CP022720.1\|AXJ30157.1\|769580_769817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227234
CP022720.1\|AXJ30163.1\|777809_779249_+\|Anaphase-promoting-complex,-cyclosome,-subunit-3	unknown	unknown	gnl\|CDD\|276808
CP022720.1\|AXJ30153.1\|763555_766087_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
CP022720.1\|AXJ30166.1\|781983_782979_+\|Gluconeogenesis-factor	unknown	unknown	gnl\|CDD\|211689
CP022720.1\|AXJ30152.1\|762569_763142_+\|Putative-sigma-54-modulation-protein	unknown	unknown	gnl\|CDD\|224461

Protein	Function_ID	Function_description	E-value
CP022720.1\|AXJ30161.1\|776469_777309_+\|Prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
CP022720.1\|AXJ30159.1\|772078_774925_+\|UvrABC-system-protein-A	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
CP022720.1\|AXJ30156.1\|768933_769584_+\|5'-deoxynucleotidase-YfbR	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
CP022720.1\|AXJ30160.1\|775531_776464_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
CP022720.1\|AXJ30162.1\|777316_777802_+\|Maltose-O-acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
CP022720.1\|AXJ30151.1\|761834_762509_+\|DNA-utilization-protein-GntX	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.0058e-51
CP022720.1\|AXJ30169.1\|785436_786339_-\|Epimerase-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
CP022720.1\|AXJ30150.1\|760759_761842_+\|primosome-assembly-protein-PriA	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	2.28878e-178
CP022720.1\|AXJ30167.1\|783089_784034_+\|Putative-sporulation-transcription-regulator-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
CP022720.1\|AXJ30155.1\|767920_768760_+\|Secretory-antigen-SsaA-precursor	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.82721e-42
CP022720.1\|AXJ30158.1\|770085_772071_+\|UvrABC-system-protein-B	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
CP022720.1\|AXJ30154.1\|766519_767512_+\|Peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
CP022720.1\|AXJ30164.1\|779315_780251_+\|Thioredoxin-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
CP022720.1\|AXJ30168.1\|784606_785194_+\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
CP022720.1\|AXJ30165.1\|781075_781987_+\|glmZ(sRNA)-inactivating-NTPase	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
CP022720.1\|AXJ30157.1\|769580_769817_+\|hypothetical-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
CP022720.1\|AXJ30163.1\|777809_779249_+\|Anaphase-promoting-complex,-cyclosome,-subunit-3	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	3.57983e-06
CP022720.1\|AXJ30153.1\|763555_766087_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
CP022720.1\|AXJ30166.1\|781983_782979_+\|Gluconeogenesis-factor	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
CP022720.1\|AXJ30152.1\|762569_763142_+\|Putative-sigma-54-modulation-protein	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37

>CP022720.1|AXJ30159.1|772078_774925_+|UvrABC-system-protein-A
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>CP022720.1|AXJ30158.1|770085_772071_+|UvrABC-system-protein-B
MVEHYPFKIHSDFEPQGDQPQAIEEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQIRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>CP022720.1|AXJ30157.1|769580_769817_+|hypothetical-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>CP022720.1|AXJ30156.1|768933_769584_+|5'-deoxynucleotidase-YfbR
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>CP022720.1|AXJ30155.1|767920_768760_+|Secretory-antigen-SsaA-precursor
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKTPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>CP022720.1|AXJ30154.1|766519_767512_+|Peptide-chain-release-factor-2
MAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>CP022720.1|AXJ30153.1|763555_766087_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>CP022720.1|AXJ30152.1|762569_763142_+|Putative-sigma-54-modulation-protein
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>CP022720.1|AXJ30151.1|761834_762509_+|DNA-utilization-protein-GntX
MNNCLSCGAKLYENITIYNLFKKPNRLCDRCKENWDNIKLDIKARRCSRCLKHLNQDEAYCLDCKFLSAHFNLMEQLYCQFQYDGLMKEMIHQYKFLKDYYLCELLAHLIEIPQTSYDYIVPIPSSPAHDLSRTFNPVEAVLKAKGIRFDKILKMSNRPKQSHLTKKERLADENPFIIDTELDLNGKEILLVDDIYTTGLTIHRAGCKLYAKNIRKFKVFAFAR
>CP022720.1|AXJ30150.1|760759_761842_+|primosome-assembly-protein-PriA
MDNVTRYKITESSQSSSQAYYHLSFEMSEQQSYASEHIVRAIRMRQTILLYAVTGAGKTEMMFQGIQYARIQGDNIAIVSPRVDVVVEISKRIKDAFLNEDIDILHQQSRQQFEGHFVVCTVHQLYRFKQHFDTIFIDEVDAFPLSMDKNLQQALKSSSKVEHATIYMTATPPKQLLSEIPHENIIKLPARFHKKSLPVPKYRYFKLNNKKIQKMLYRILQDQINNQRYTLVFFNNIETMIKTFSVYKQKITKLTYVHSEDVFRFEKVEQLRNGHFDVIFTTTILERGFTMANLDVVVIDAHQYTQEALIQIAGRVGRKLECPTGKVLFFHEGVSMNMIQAKKEIQRMNKLALKRGWIDE
>CP022720.1|AXJ30160.1|775531_776464_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>CP022720.1|AXJ30161.1|776469_777309_+|Prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>CP022720.1|AXJ30162.1|777316_777802_+|Maltose-O-acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>CP022720.1|AXJ30163.1|777809_779249_+|Anaphase-promoting-complex,-cyclosome,-subunit-3
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>CP022720.1|AXJ30164.1|779315_780251_+|Thioredoxin-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>CP022720.1|AXJ30165.1|781075_781987_+|glmZ(sRNA)-inactivating-NTPase
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>CP022720.1|AXJ30166.1|781983_782979_+|Gluconeogenesis-factor
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>CP022720.1|AXJ30167.1|783089_784034_+|Putative-sporulation-transcription-regulator-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>CP022720.1|AXJ30168.1|784606_785194_+|ATP-dependent-Clp-protease-proteolytic-subunit
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>CP022720.1|AXJ30169.1|785436_786339_-|Epimerase-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE

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Crispr_ID: CP022720_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022720_2

780708-780791

Unclear

Consensus_repeat	Method
TCTGTGTTGGCGCCCACACCCCAACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022720_2

>merge|CP022720|2|780708-780791|CRISPRCasFinder
TCTGTGTTGGCGCCCACACCCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCACACCCCAACT

>CP022720|2|2|780708-780791|CRISPRCasFinder
TCTGTGTTGGCGCCCACACCCCAACT	CGCATTGCCTGTAGAATTTCTTTTCGAAATTC
TCTGTGTTGGGGCCCACACCCCAACT

Protein	Signature genes	Signature genes Name	Protein_function
CP022720.1\|AXJ30172.1\|789491_790502_+\|Glyceraldehyde-3-phosphate-dehydrogenase-1	unknown	unknown	gnl\|CDD\|273675
CP022720.1\|AXJ30173.1\|790639_791830_+\|Phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
CP022720.1\|AXJ30161.1\|776469_777309_+\|Prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
CP022720.1\|AXJ30159.1\|772078_774925_+\|UvrABC-system-protein-A	unknown	unknown	gnl\|CDD\|234734
CP022720.1\|AXJ30156.1\|768933_769584_+\|5'-deoxynucleotidase-YfbR	unknown	unknown	gnl\|CDD\|378993
CP022720.1\|AXJ30163.1\|777809_779249_+\|Anaphase-promoting-complex,-cyclosome,-subunit-3	unknown	unknown	gnl\|CDD\|276808
CP022720.1\|AXJ30164.1\|779315_780251_+\|Thioredoxin-reductase	unknown	unknown	gnl\|CDD\|273540
CP022720.1\|AXJ30170.1\|787041_787671_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234750
CP022720.1\|AXJ30169.1\|785436_786339_-\|Epimerase-family-protein	unknown	unknown	gnl\|CDD\|224015
CP022720.1\|AXJ30171.1\|788425_789439_+\|Central-glycolytic-genes-regulator	unknown	unknown	gnl\|CDD\|225263
CP022720.1\|AXJ30166.1\|781983_782979_+\|Gluconeogenesis-factor	unknown	unknown	gnl\|CDD\|211689
CP022720.1\|AXJ30155.1\|767920_768760_+\|Secretory-antigen-SsaA-precursor	unknown	unknown	gnl\|CDD\|226451
CP022720.1\|AXJ30158.1\|770085_772071_+\|UvrABC-system-protein-B	unknown	unknown	gnl\|CDD\|235395
CP022720.1\|AXJ30160.1\|775531_776464_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
CP022720.1\|AXJ30168.1\|784606_785194_+\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
CP022720.1\|AXJ30157.1\|769580_769817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227234
CP022720.1\|AXJ30165.1\|781075_781987_+\|glmZ(sRNA)-inactivating-NTPase	unknown	unknown	gnl\|CDD\|224574
CP022720.1\|AXJ30167.1\|783089_784034_+\|Putative-sporulation-transcription-regulator-WhiA	unknown	unknown	gnl\|CDD\|273194
CP022720.1\|AXJ30162.1\|777316_777802_+\|Maltose-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100053
CP022720.1\|AXJ30174.1\|791951_792713_+\|Triosephosphate-isomerase	unknown	unknown	gnl\|CDD\|234589

Protein	Function_ID	Function_description	E-value
CP022720.1\|AXJ30172.1\|789491_790502_+\|Glyceraldehyde-3-phosphate-dehydrogenase-1	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
CP022720.1\|AXJ30173.1\|790639_791830_+\|Phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
CP022720.1\|AXJ30161.1\|776469_777309_+\|Prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
CP022720.1\|AXJ30159.1\|772078_774925_+\|UvrABC-system-protein-A	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
CP022720.1\|AXJ30156.1\|768933_769584_+\|5'-deoxynucleotidase-YfbR	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
CP022720.1\|AXJ30163.1\|777809_779249_+\|Anaphase-promoting-complex,-cyclosome,-subunit-3	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	3.57983e-06
CP022720.1\|AXJ30164.1\|779315_780251_+\|Thioredoxin-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
CP022720.1\|AXJ30170.1\|787041_787671_+\|hypothetical-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.85535e-05
CP022720.1\|AXJ30169.1\|785436_786339_-\|Epimerase-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
CP022720.1\|AXJ30171.1\|788425_789439_+\|Central-glycolytic-genes-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
CP022720.1\|AXJ30166.1\|781983_782979_+\|Gluconeogenesis-factor	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
CP022720.1\|AXJ30155.1\|767920_768760_+\|Secretory-antigen-SsaA-precursor	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.82721e-42
CP022720.1\|AXJ30158.1\|770085_772071_+\|UvrABC-system-protein-B	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
CP022720.1\|AXJ30160.1\|775531_776464_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
CP022720.1\|AXJ30168.1\|784606_785194_+\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
CP022720.1\|AXJ30157.1\|769580_769817_+\|hypothetical-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
CP022720.1\|AXJ30165.1\|781075_781987_+\|glmZ(sRNA)-inactivating-NTPase	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
CP022720.1\|AXJ30167.1\|783089_784034_+\|Putative-sporulation-transcription-regulator-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
CP022720.1\|AXJ30162.1\|777316_777802_+\|Maltose-O-acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
CP022720.1\|AXJ30174.1\|791951_792713_+\|Triosephosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	1.58979e-145

>CP022720.1|AXJ30164.1|779315_780251_+|Thioredoxin-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>CP022720.1|AXJ30163.1|777809_779249_+|Anaphase-promoting-complex,-cyclosome,-subunit-3
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>CP022720.1|AXJ30162.1|777316_777802_+|Maltose-O-acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>CP022720.1|AXJ30161.1|776469_777309_+|Prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>CP022720.1|AXJ30160.1|775531_776464_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>CP022720.1|AXJ30159.1|772078_774925_+|UvrABC-system-protein-A
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>CP022720.1|AXJ30158.1|770085_772071_+|UvrABC-system-protein-B
MVEHYPFKIHSDFEPQGDQPQAIEEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQIRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>CP022720.1|AXJ30157.1|769580_769817_+|hypothetical-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>CP022720.1|AXJ30156.1|768933_769584_+|5'-deoxynucleotidase-YfbR
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>CP022720.1|AXJ30155.1|767920_768760_+|Secretory-antigen-SsaA-precursor
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKTPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>CP022720.1|AXJ30165.1|781075_781987_+|glmZ(sRNA)-inactivating-NTPase
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>CP022720.1|AXJ30166.1|781983_782979_+|Gluconeogenesis-factor
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>CP022720.1|AXJ30167.1|783089_784034_+|Putative-sporulation-transcription-regulator-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>CP022720.1|AXJ30168.1|784606_785194_+|ATP-dependent-Clp-protease-proteolytic-subunit
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>CP022720.1|AXJ30169.1|785436_786339_-|Epimerase-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>CP022720.1|AXJ30170.1|787041_787671_+|hypothetical-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>CP022720.1|AXJ30171.1|788425_789439_+|Central-glycolytic-genes-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>CP022720.1|AXJ30172.1|789491_790502_+|Glyceraldehyde-3-phosphate-dehydrogenase-1
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>CP022720.1|AXJ30173.1|790639_791830_+|Phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>CP022720.1|AXJ30174.1|791951_792713_+|Triosephosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKYGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK

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Crispr_ID: CP022720_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022720_4

1739095-1739177

Orphan

Consensus_repeat	Method
ATGCAAGTTGGGGTGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022720_4

>merge|CP022720|4|1739095-1739177|CRISPRCasFinder
ATGCAAGTTGGGGTGGGGCCCCAACACAGAGAATTTCGAAAAGAAATTCTACAGACCATGCAAGTTGGGGTGGGGCCCAACAT

>CP022720|4|4|1739095-1739177|CRISPRCasFinder
ATGCAAGTTGGGGTGGGGCCCCAACA	CAGAGAATTTCGAAAAGAAATTCTACAGACC
ATGCAAGTTGGGGTGGGGCCCAACAT

Protein	Signature genes	Signature genes Name	Protein_function
CP022720.1\|AXJ31053.1\|1731929_1732787_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
CP022720.1\|AXJ31066.1\|1748825_1749596_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182593
CP022720.1\|AXJ31064.1\|1747163_1748111_-\|N-6-DNA-Methylase	unknown	unknown	gnl\|CDD\|223897
CP022720.1\|AXJ31052.1\|1730985_1731930_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
CP022720.1\|AXJ31059.1\|1741633_1742323_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
CP022720.1\|AXJ31057.1\|1739271_1740570_-\|Cobalt-dependent-inorganic-pyrophosphatase	unknown	unknown	gnl\|CDD\|226594
CP022720.1\|AXJ31055.1\|1734660_1737858_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
CP022720.1\|AXJ31050.1\|1727969_1729727_-\|Pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
CP022720.1\|AXJ31048.1\|1724791_1725913_-\|Citrate-synthase-2	unknown	unknown	gnl\|CDD\|184468
CP022720.1\|AXJ31058.1\|1740774_1741188_+\|Stress-response-protein-NhaX	unknown	unknown	gnl\|CDD\|366180
CP022720.1\|AXJ31062.1\|1745127_1745628_+\|Putative-universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
CP022720.1\|AXJ31061.1\|1743868_1744987_-\|Alanine-dehydrogenase-2	unknown	unknown	gnl\|CDD\|240630
CP022720.1\|AXJ31056.1\|1737878_1738820_-\|Bifunctional-oligoribonuclease-and-PAP-phosphatase-NrnA	unknown	unknown	gnl\|CDD\|223691
CP022720.1\|AXJ31051.1\|1729748_1730717_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
CP022720.1\|AXJ31049.1\|1726260_1727622_+\|D-serine/D-alanine/glycine-transporter	unknown	unknown	gnl\|CDD\|224038
CP022720.1\|AXJ31060.1\|1742497_1743553_+\|putative-peptidase	unknown	unknown	gnl\|CDD\|223085
CP022720.1\|AXJ31054.1\|1732981_1734211_-\|NAD-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|235976
CP022720.1\|AXJ31063.1\|1745873_1747076_-\|Acetate-kinase	unknown	unknown	gnl\|CDD\|234680
CP022720.1\|AXJ31047.1\|1723474_1724743_-\|Isocitrate-dehydrogenase-[NADP]	unknown	unknown	gnl\|CDD\|180792
CP022720.1\|AXJ31065.1\|1748233_1748728_-\|putative-thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055

Protein	Function_ID	Function_description	E-value
CP022720.1\|AXJ31053.1\|1731929_1732787_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
CP022720.1\|AXJ31066.1\|1748825_1749596_-\|hypothetical-protein	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.16064e-38
CP022720.1\|AXJ31064.1\|1747163_1748111_-\|N-6-DNA-Methylase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	1.59776e-55
CP022720.1\|AXJ31052.1\|1730985_1731930_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
CP022720.1\|AXJ31059.1\|1741633_1742323_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	3.09103e-133
CP022720.1\|AXJ31057.1\|1739271_1740570_-\|Cobalt-dependent-inorganic-pyrophosphatase	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
CP022720.1\|AXJ31055.1\|1734660_1737858_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
CP022720.1\|AXJ31050.1\|1727969_1729727_-\|Pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
CP022720.1\|AXJ31048.1\|1724791_1725913_-\|Citrate-synthase-2	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
CP022720.1\|AXJ31058.1\|1740774_1741188_+\|Stress-response-protein-NhaX	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
CP022720.1\|AXJ31062.1\|1745127_1745628_+\|Putative-universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
CP022720.1\|AXJ31061.1\|1743868_1744987_-\|Alanine-dehydrogenase-2	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
CP022720.1\|AXJ31056.1\|1737878_1738820_-\|Bifunctional-oligoribonuclease-and-PAP-phosphatase-NrnA	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	2.2886e-98
CP022720.1\|AXJ31051.1\|1729748_1730717_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
CP022720.1\|AXJ31049.1\|1726260_1727622_+\|D-serine/D-alanine/glycine-transporter	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
CP022720.1\|AXJ31060.1\|1742497_1743553_+\|putative-peptidase	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	7.02579e-126
CP022720.1\|AXJ31054.1\|1732981_1734211_-\|NAD-dependent-malic-enzyme	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
CP022720.1\|AXJ31063.1\|1745873_1747076_-\|Acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
CP022720.1\|AXJ31047.1\|1723474_1724743_-\|Isocitrate-dehydrogenase-[NADP]	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
CP022720.1\|AXJ31065.1\|1748233_1748728_-\|putative-thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	5.93419e-100

>CP022720.1|AXJ31056.1|1737878_1738820_-|Bifunctional-oligoribonuclease-and-PAP-phosphatase-NrnA
MISTLNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGRKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLEQFGIHPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVDSWDEFEQLATALRTKLN
>CP022720.1|AXJ31055.1|1734660_1737858_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTVETVVLVKNNDGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKKVGDQHRDIVQVFETHNDIYMDHLSISIQGRKHVWIQDVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEIKQLDINQEYLTQVDVIAQKCNAELKYHQSLLPQYETPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKYKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVILNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVMLSFYDETIKQMTTIGYINQKDSMFNNFIQSFNPSDIRLI
>CP022720.1|AXJ31054.1|1732981_1734211_-|NAD-dependent-malic-enzyme
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTMAGLVNALRVINKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>CP022720.1|AXJ31053.1|1731929_1732787_-|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLERHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>CP022720.1|AXJ31052.1|1730985_1731930_-|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVAQLDSLESLSRDEIANDRFEKFRNIGSYIE
>CP022720.1|AXJ31051.1|1729748_1730717_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>CP022720.1|AXJ31050.1|1727969_1729727_-|Pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>CP022720.1|AXJ31049.1|1726260_1727622_+|D-serine/D-alanine/glycine-transporter
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAVKSNK
>CP022720.1|AXJ31048.1|1724791_1725913_-|Citrate-synthase-2
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKDPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>CP022720.1|AXJ31047.1|1723474_1724743_-|Isocitrate-dehydrogenase-[NADP]
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVEKEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>CP022720.1|AXJ31057.1|1739271_1740570_-|Cobalt-dependent-inorganic-pyrophosphatase
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVINFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANRTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>CP022720.1|AXJ31058.1|1740774_1741188_+|Stress-response-protein-NhaX
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>CP022720.1|AXJ31059.1|1741633_1742323_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>CP022720.1|AXJ31060.1|1742497_1743553_+|putative-peptidase
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLTSGFNVNSFGDVDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGNRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
>CP022720.1|AXJ31061.1|1743868_1744987_-|Alanine-dehydrogenase-2
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>CP022720.1|AXJ31062.1|1745127_1745628_+|Putative-universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>CP022720.1|AXJ31063.1|1745873_1747076_-|Acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLIERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIDGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTFGGLK
>CP022720.1|AXJ31064.1|1747163_1748111_-|N-6-DNA-Methylase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNDRGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMSLPLEEADIVIGDFPVGYYPIDERSKEFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>CP022720.1|AXJ31065.1|1748233_1748728_-|putative-thiol-peroxidase
MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>CP022720.1|AXJ31066.1|1748825_1749596_-|hypothetical-protein
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSTIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAIIFAALFILIGFYDGFVGGGTGSFMLFVLLVFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLIMAISMIAGSYAGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFV

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Crispr_ID: CP022720_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022720_5

2403465-2403562

Orphan

Consensus_repeat	Method
TTTCTGCGAATTTTATGAGCTAGAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022720_5

>merge|CP022720|5|2403465-2403562|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCATTAGTAGCGAAGCTAACTAATGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGC

>CP022720|5|5|2403465-2403562|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGC	TTATGCATTAGTAGCGAAGCTAACTAATGCGTTCCTTTAT
TTTCTGCGAATTTTATGAGCTAGAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
CP022720.1\|AXJ31669.1\|2405767_2406733_+\|Gamma-hemolysin-component-A-precursor	unknown	unknown	gnl\|CDD\|369625
CP022720.1\|AXJ31661.1\|2397246_2397978_-\|L-cystine-import-ATP-binding-protein-TcyC	unknown	unknown	gnl\|CDD\|224051
CP022720.1\|AXJ31667.1\|2402458_2403325_-\|Ferrous-iron-efflux-pump-FieF	unknown	unknown	gnl\|CDD\|223131
CP022720.1\|AXJ31675.1\|2411551_2412559_-\|Biotin-synthase	unknown	unknown	gnl\|CDD\|235755
CP022720.1\|AXJ31662.1\|2397974_2398703_-\|L-cystine-transport-system-permease-protein-TcyB	unknown	unknown	gnl\|CDD\|223836
CP022720.1\|AXJ31670.1\|2407299_2408247_+\|Gamma-hemolysin-component-C-precursor	unknown	unknown	gnl\|CDD\|369625
CP022720.1\|AXJ31666.1\|2401445_2402132_-\|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
CP022720.1\|AXJ31663.1\|2398674_2399454_-\|putative-amino-acid-ABC-transporter-binding-protein-precursor	unknown	unknown	gnl\|CDD\|270429
CP022720.1\|AXJ31668.1\|2403954_2405268_+\|Immunoglobulin-binding-protein-sbi-precursor	unknown	unknown	gnl\|CDD\|288473
CP022720.1\|AXJ31674.1\|2410458_2411574_-\|8-amino-7-oxononanoate-synthase/2-amino-3-ketobutyrate-coenzyme-A-ligase	unknown	unknown	gnl\|CDD\|223234
CP022720.1\|AXJ31659.1\|2395282_2395645_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|291399
CP022720.1\|AXJ31671.1\|2408248_2409226_+\|Gamma-hemolysin-component-B-precursor	unknown	unknown	gnl\|CDD\|273388
CP022720.1\|AXJ31665.1\|2401187_2401292_+\|hypothetical-protein	unknown	unknown	unknown
CP022720.1\|AXJ31672.1\|2409277_2409745_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377623
CP022720.1\|AXJ31658.1\|2394664_2395264_-\|Disulfide-bond-formation-protein-D-precursor	unknown	unknown	gnl\|CDD\|224565
CP022720.1\|AXJ31664.1\|2399574_2401014_-\|Multidrug-export-protein-EmrB	unknown	unknown	gnl\|CDD\|129794
CP022720.1\|AXJ31660.1\|2395899_2397150_+\|Aminoacyltransferase-FemA	unknown	unknown	gnl\|CDD\|367067
CP022720.1\|AXJ31673.1\|2409755_2410448_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
CP022720.1\|AXJ31676.1\|2412560_2413919_-\|L-Lysine-8-amino-7-oxononanoate-aminotransferase	unknown	unknown	gnl\|CDD\|273109
CP022720.1\|AXJ31677.1\|2413896_2414583_-\|ATP-dependent-dethiobiotin-synthetase-BioD-1	unknown	unknown	gnl\|CDD\|223210

Protein	Function_ID	Function_description	E-value
CP022720.1\|AXJ31669.1\|2405767_2406733_+\|Gamma-hemolysin-component-A-precursor	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	6.13066e-97
CP022720.1\|AXJ31661.1\|2397246_2397978_-\|L-cystine-import-ATP-binding-protein-TcyC	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.20826e-144
CP022720.1\|AXJ31667.1\|2402458_2403325_-\|Ferrous-iron-efflux-pump-FieF	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.54055e-90
CP022720.1\|AXJ31675.1\|2411551_2412559_-\|Biotin-synthase	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
CP022720.1\|AXJ31662.1\|2397974_2398703_-\|L-cystine-transport-system-permease-protein-TcyB	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.24685e-78
CP022720.1\|AXJ31670.1\|2407299_2408247_+\|Gamma-hemolysin-component-C-precursor	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.97441e-93
CP022720.1\|AXJ31666.1\|2401445_2402132_-\|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
CP022720.1\|AXJ31663.1\|2398674_2399454_-\|putative-amino-acid-ABC-transporter-binding-protein-precursor	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.20682e-100
CP022720.1\|AXJ31668.1\|2403954_2405268_+\|Immunoglobulin-binding-protein-sbi-precursor	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	4.53353e-27
CP022720.1\|AXJ31674.1\|2410458_2411574_-\|8-amino-7-oxononanoate-synthase/2-amino-3-ketobutyrate-coenzyme-A-ligase	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	1.99808e-138
CP022720.1\|AXJ31659.1\|2395282_2395645_-\|hypothetical-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.11961e-31
CP022720.1\|AXJ31671.1\|2408248_2409226_+\|Gamma-hemolysin-component-B-precursor	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
CP022720.1\|AXJ31672.1\|2409277_2409745_-\|hypothetical-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.000705213
CP022720.1\|AXJ31658.1\|2394664_2395264_-\|Disulfide-bond-formation-protein-D-precursor	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	1.74649e-30
CP022720.1\|AXJ31664.1\|2399574_2401014_-\|Multidrug-export-protein-EmrB	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.41176e-92
CP022720.1\|AXJ31660.1\|2395899_2397150_+\|Aminoacyltransferase-FemA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
CP022720.1\|AXJ31673.1\|2409755_2410448_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	1.16849e-130
CP022720.1\|AXJ31676.1\|2412560_2413919_-\|L-Lysine-8-amino-7-oxononanoate-aminotransferase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
CP022720.1\|AXJ31677.1\|2413896_2414583_-\|ATP-dependent-dethiobiotin-synthetase-BioD-1	gnl\|CDD\|223210	COG0132, BioD, Dethiobiotin synthetase [Coenzyme metabolism].	1.32211e-70

>CP022720.1|AXJ31667.1|2402458_2403325_-|Ferrous-iron-efflux-pump-FieF
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>CP022720.1|AXJ31666.1|2401445_2402132_-|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>CP022720.1|AXJ31665.1|2401187_2401292_+|hypothetical-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>CP022720.1|AXJ31664.1|2399574_2401014_-|Multidrug-export-protein-EmrB
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>CP022720.1|AXJ31663.1|2398674_2399454_-|putative-amino-acid-ABC-transporter-binding-protein-precursor
MKRLLFVMIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKADDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>CP022720.1|AXJ31662.1|2397974_2398703_-|L-cystine-transport-system-permease-protein-TcyB
MVKMFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>CP022720.1|AXJ31661.1|2397246_2397978_-|L-cystine-import-ATP-binding-protein-TcyC
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELRRFLNVINEE
>CP022720.1|AXJ31660.1|2395899_2397150_+|Aminoacyltransferase-FemA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVQTYLNHKRR
>CP022720.1|AXJ31659.1|2395282_2395645_-|hypothetical-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>CP022720.1|AXJ31658.1|2394664_2395264_-|Disulfide-bond-formation-protein-D-precursor
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>CP022720.1|AXJ31668.1|2403954_2405268_+|Immunoglobulin-binding-protein-sbi-precursor
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNVKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNKYYQYKGLIDQTVLTTIGSGYGSYIKPLEVSKESGNLAKSYAQVRNYVTESINTSKVLYAFYQKPELVKTAIKAQETATTFKNALTGIFKSFWK
>CP022720.1|AXJ31669.1|2405767_2406733_+|Gamma-hemolysin-component-A-precursor
MNLKLNRKKVISMIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>CP022720.1|AXJ31670.1|2407299_2408247_+|Gamma-hemolysin-component-C-precursor
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>CP022720.1|AXJ31671.1|2408248_2409226_+|Gamma-hemolysin-component-B-precursor
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>CP022720.1|AXJ31672.1|2409277_2409745_-|hypothetical-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSLLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>CP022720.1|AXJ31673.1|2409755_2410448_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFAAAKIGYHRLFDIKPVNTRYGGRIIFVDNRIDLNHYISFLESTPKQVVYETV
>CP022720.1|AXJ31674.1|2410458_2411574_-|8-amino-7-oxononanoate-synthase/2-amino-3-ketobutyrate-coenzyme-A-ligase
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED
>CP022720.1|AXJ31675.1|2411551_2412559_-|Biotin-synthase
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>CP022720.1|AXJ31676.1|2412560_2413919_-|L-Lysine-8-amino-7-oxononanoate-aminotransferase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGVVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRKCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC
>CP022720.1|AXJ31677.1|2413896_2414583_-|ATP-dependent-dethiobiotin-synthetase-BioD-1
MRIFITSTNTDVGKTYVTKHLYHALKTRGHRVCIFKPFQTEERQDGTFPDLEVFKNECDLSYDITSLYTFKQPVSPHLAFKMTDQIFLNKQRVLDKVKVLDKEFDFILIEGAGGIAVPIYEGTYDFYMTKDLINDCADCVISVLPSKLGAISDAIVHQDYVNQNVSASNFLIMNRYTDSYIEKDNQITIGKLTNKTVYTFEEHATYENFSEAFLKQLIGVKNELHTTT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	1092617-1092645	0	1.0
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	2689281-2689309	0	1.0
CP022720_2	2.1\|780734\|32\|CP022720\|CRISPRCasFinder	780734-780765	32	CP022720.1	1022031-1022062	0	1.0
CP022720_2	2.1\|780734\|32\|CP022720\|CRISPRCasFinder	780734-780765	32	CP022720.1	1305255-1305286	0	1.0
CP022720_2	2.1\|780734\|32\|CP022720\|CRISPRCasFinder	780734-780765	32	CP022720.1	1392962-1392993	0	1.0
CP022720_2	2.1\|780734\|32\|CP022720\|CRISPRCasFinder	780734-780765	32	CP022720.1	1945405-1945436	0	1.0
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	249159-249187	1	0.966
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	331567-331595	1	0.966
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	331622-331650	1	0.966
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	1620361-1620389	1	0.966
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	1741402-1741430	1	0.966
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	1796596-1796624	1	0.966
CP022720_2	2.1\|780734\|32\|CP022720\|CRISPRCasFinder	780734-780765	32	CP022720.1	1652925-1652956	1	0.969
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	129752-129780	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	129810-129838	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	995474-995502	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	1180859-1180887	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	1954813-1954841	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	2253166-2253194	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	2444208-2444236	2	0.931
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	CP022720.1	2444266-2444294	2	0.931
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	233994-234025	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	331450-331481	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	995532-995563	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	995648-995679	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	1096809-1096840	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	1180797-1180828	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	1305313-1305344	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	1392904-1392935	2	0.938
CP022720_3	3.1\|1652984\|32\|CP022720\|CRISPRCasFinder	1652984-1653015	32	CP022720.1	1796707-1796738	2	0.938

1. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 1092617-1092645, mismatch: 0, identity: 1.0

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtagaatttcttttcgaaa	Protospacer
*****************************

2. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 2689281-2689309, mismatch: 0, identity: 1.0

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtagaatttcttttcgaaa	Protospacer
*****************************

3. spacer 2.1|780734|32|CP022720|CRISPRCasFinder matches to position: 1022031-1022062, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

4. spacer 2.1|780734|32|CP022720|CRISPRCasFinder matches to position: 1305255-1305286, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

5. spacer 2.1|780734|32|CP022720|CRISPRCasFinder matches to position: 1392962-1392993, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

6. spacer 2.1|780734|32|CP022720|CRISPRCasFinder matches to position: 1945405-1945436, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

7. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 249159-249187, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

8. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 331567-331595, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

9. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 331622-331650, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

10. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 1620361-1620389, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

11. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 1741402-1741430, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

12. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 1796596-1796624, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

13. spacer 2.1|780734|32|CP022720|CRISPRCasFinder matches to position: 1652925-1652956, mismatch: 1, identity: 0.969

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttctttacgaaattc	Protospacer
*********************** ********

14. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 129752-129780, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

15. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 129810-129838, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

16. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 995474-995502, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

17. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 1180859-1180887, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

18. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 1954813-1954841, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaa	Protospacer
********.***********.********

19. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 2253166-2253194, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttctttttgaaa	Protospacer
********.***************.****

20. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 2444208-2444236, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

21. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to position: 2444266-2444294, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

22. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 233994-234025, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

23. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 331450-331481, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

24. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 995532-995563, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

25. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 995648-995679, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

26. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 1096809-1096840, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

27. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 1180797-1180828, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

28. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 1305313-1305344, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

29. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 1392904-1392935, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

30. spacer 3.1|1652984|32|CP022720|CRISPRCasFinder matches to position: 1796707-1796738, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgaaagctgactattggccagct	Protospacer
********************* ****.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP022720_1	1.1\|775241\|29\|CP022720\|CRISPRCasFinder	775241-775269	29	MN693281	Marine virus AFVG_25M371, complete genome	6448-6476	7	0.759
CP022720_2	2.1\|780734\|32\|CP022720\|CRISPRCasFinder	780734-780765	32	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	270872-270903	8	0.75
CP022720_4	4.1\|1739121\|31\|CP022720\|CRISPRCasFinder	1739121-1739151	31	KM359505	Prochlorococcus phage P-TIM68, complete genome	102706-102736	8	0.742

1. spacer 1.1|775241|29|CP022720|CRISPRCasFinder matches to MN693281 (Marine virus AFVG_25M371, complete genome) position: , mismatch: 7, identity: 0.759

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtaggatttcttctaagtg	Protospacer
**************.*******.* .. .

2. spacer 2.1|780734|32|CP022720|CRISPRCasFinder matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 8, identity: 0.75

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
tgcattacctgtagcatttcttttttcaacta	Protospacer
.*****.******* *********.  **.*

3. spacer 4.1|1739121|31|CP022720|CRISPRCasFinder matches to KM359505 (Prochlorococcus phage P-TIM68, complete genome) position: , mismatch: 8, identity: 0.742

cagagaatttcgaaaagaaattctacagacc	CRISPR spacer
ttaactatttccaaaagaaattatacagatc	Protospacer
. .*  ***** ********** ******.*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

712438 : 720258

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ30106.1\|712438_713494_-	Histidine protein kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
AXJ30107.1\|713493_714180_-	Response regulator SaeR	NA	NA	NA	NA
AXJ30108.1\|714154_714628_-	DoxX	NA	NA	NA	NA
AXJ30109.1\|714969_715410_-	Electron transfer DM13	NA	NA	NA	NA
AXJ30110.1\|715689_716274_-	hypothetical protein	NA	NA	NA	NA
AXJ30111.1\|716372_717086_-	7-carboxy-7-deazaguanine synthase	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
AXJ30112.1\|717089_717509_-	6-carboxy-5,6,7,8-tetrahydropterin synthase	S4U060	uncultured_phage	6.3e-07	28.7
AXJ30113.1\|717510_718179_-	7-cyano-7-deazaguanine synthase	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
AXJ30114.1\|718529_719123_+	Anthranilate synthase component 2	A0A0P0IKJ1	Acinetobacter_phage	1.2e-38	43.5
AXJ30115.1\|719106_720258_+	Aminodeoxychorismate synthase component 1	S4VNU7	Pandoravirus	3.5e-23	36.1

DBSCAN-SWA_2

732229 : 746848

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ30124.1\|732229_733288_+	Histidinol-phosphate aminotransferase	A0A0H3TLT9	Faustovirus	1.5e-20	27.3
AXJ30125.1\|733638_734181_+	Putative 5'(3')-deoxyribonucleotidase	NA	NA	NA	NA
AXJ30126.1\|734804_735722_-	Putative lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.0
AXJ30127.1\|735991_737497_-	Di-/tripeptide transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
AXJ30128.1\|737837_738338_-	NADPH-dependent 7-cyano-7-deazaguanine reductase	E7DN65	Pneumococcus_phage	5.9e-52	71.5
AXJ30129.1\|738357_739224_-	EamA-like transporter family protein	NA	NA	NA	NA
AXJ30130.1\|740024_740423_+	ribonucleotide reductase stimulatory protein	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
AXJ30131.1\|740385_742491_+	Ribonucleoside-diphosphate reductase subunit alpha 2	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
AXJ30132.1\|742608_743580_+	Ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
AXJ30133.1\|744133_745147_+	Fe(3+) dicitrate transport system permease protein FecD	A0A2H4IY97	uncultured_Caudovirales_phage	2.2e-138	78.0
AXJ30134.1\|745133_746090_+	Iron-uptake system permease protein FeuC	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
AXJ30135.1\|746086_746848_+	putative siderophore transport system ATP-binding protein YusV	Q9EMR9	Amsacta_moorei_entomopoxvirus	8.5e-18	31.6

DBSCAN-SWA_3

997156 : 1005629

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ30369.1\|997156_997639_+	N5-carboxyaminoimidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
AXJ30370.1\|997625_998750_+	N5-carboxyaminoimidazole ribonucleotide synthase	NA	NA	NA	NA
AXJ30371.1\|998753_999458_+	Phosphoribosylaminoimidazole-succinocarboxamide synthase	M4R1E8	Synechococcus_phage	8.1e-47	41.6
AXJ30372.1\|999457_999721_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AXJ30373.1\|999722_1000394_+	Phosphoribosylformylglycinamidine synthase 1	NA	NA	NA	NA
AXJ30374.1\|1000386_1002576_+	Phosphoribosylformylglycinamidine synthase 2	A6N228	Microbacterium_phage	2.7e-141	39.8
AXJ30375.1\|1002554_1004039_+	Amidophosphoribosyltransferase precursor	A0A0M3SGR2	Mollivirus	3.2e-45	31.7
AXJ30376.1\|1004031_1005060_+	Phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.5e-62	41.7
AXJ30377.1\|1005062_1005629_+	Phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.2e-30	40.7

DBSCAN-SWA_4

1446254 : 1533144

101

Staphylococcus_phage(72.73%)

head,portal,lysis,tail,terminase,capsid,protease,tRNA,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ30758.1\|1446254_1447547_-\|tRNA	Asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.9e-54	30.0
AXJ30759.1\|1447868_1450562_-	hypothetical protein	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
AXJ30760.1\|1450585_1451557_-	Bifunctional ligase/repressor BirA	NA	NA	NA	NA
AXJ30761.1\|1451543_1452746_-	CCA-adding enzyme	H7BUW3	unidentified_phage	1.2e-34	42.0
AXJ30762.1\|1452750_1453893_-	GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase	NA	NA	NA	NA
AXJ30763.1\|1454133_1454451_-	nucleoside triphosphate pyrophosphohydrolase	NA	NA	NA	NA
AXJ30764.1\|1454787_1455486_-	Putative neutral zinc metallopeptidase	NA	NA	NA	NA
AXJ30765.1\|1455539_1456127_-	hypothetical protein	NA	NA	NA	NA
AXJ30766.1\|1456116_1456704_-	hypothetical protein	G3MAV7	Bacillus_virus	2.8e-08	27.2
AXJ30767.1\|1456705_1457950_-	tetratricopeptide repeat protein	NA	NA	NA	NA
AXJ30768.1\|1457956_1459255_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
AXJ30769.1\|1459264_1460329_-	3-dehydroquinate synthase	NA	NA	NA	NA
AXJ30770.1\|1460354_1461521_-	Chorismate synthase	A0A291AU41	Pandoravirus	7.6e-34	32.1
AXJ30771.1\|1461906_1462107_-	hypothetical protein	NA	NA	NA	NA
AXJ30772.1\|1462315_1462765_-	Nucleoside diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
AXJ30773.1\|1462856_1463816_-	Heptaprenyl diphosphate synthase component 2	A0A1V0SE37	Indivirus	1.3e-10	24.4
AXJ30774.1\|1463817_1464543_-	Demethylmenaquinone methyltransferase	NA	NA	NA	NA
AXJ30775.1\|1464545_1465118_-	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1	NA	NA	NA	NA
AXJ30776.1\|1465548_1465821_-	DNA-binding protein HU	A7KV42	Bacillus_phage	4.2e-28	73.3
AXJ30777.1\|1465991_1466990_-	Glycerol-3-phosphate dehydrogenase [NAD(P)+]	NA	NA	NA	NA
AXJ30778.1\|1467006_1468317_-	GTPase Der	NA	NA	NA	NA
AXJ30779.1\|1468538_1469714_-	30S ribosomal protein S1	NA	NA	NA	NA
AXJ30780.1\|1470411_1471071_-	Cytidylate kinase	NA	NA	NA	NA
AXJ30781.1\|1471147_1472116_+	putative L-asparaginase	NA	NA	NA	NA
AXJ30782.1\|1472230_1473217_-	Glucosaminate ammonia-lyase	NA	NA	NA	NA
AXJ30783.1\|1473618_1475073_-	Elastin-binding protein EbpS	NA	NA	NA	NA
AXJ30784.1\|1475225_1476605_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	3.8e-56	33.3
AXJ30785.1\|1476594_1477548_-	hypothetical protein	NA	NA	NA	NA
AXJ30786.1\|1477655_1477904_+	Ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
AXJ30787.1\|1478009_1478555_-	Riboflavin transporter RibU	NA	NA	NA	NA
AXJ30788.1\|1478956_1479889_-	hypothetical protein	NA	NA	NA	NA
AXJ30789.1\|1479945_1480863_-	hypothetical protein	NA	NA	NA	NA
AXJ30790.1\|1480920_1481826_-	hypothetical protein	NA	NA	NA	NA
AXJ30791.1\|1481916_1482168_-	hypothetical protein	A0ZS61	Staphylococcus_virus	2.4e-25	100.0
AXJ30792.1\|1482551_1483337_-	hypothetical protein	D2JLG6	Staphylococcus_phage	1.8e-140	98.1
AXJ30793.1\|1483952_1485407_-	putative cell wall hydrolase LytN precursor	Q8SDN4	Staphylococcus_virus	7.5e-289	99.8
AXJ30794.1\|1485417_1485720_-\|holin,lysis	Phage lysis protein, holin	B7T0L0	Staphylococcus_virus	4.1e-48	100.0
AXJ30795.1\|1485855_1486155_-	hypothetical protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
AXJ30796.1\|1486200_1486365_-	hypothetical protein	A0A2I6PES4	Staphylococcus_phage	4.9e-24	100.0
AXJ30797.1\|1486357_1486747_-	hypothetical protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
AXJ30798.1\|1486746_1488213_-	hypothetical protein	Q8SDN8	Staphylococcus_virus	3.4e-257	100.0
AXJ30799.1\|1488212_1490123_-	hypothetical protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	100.0
AXJ30800.1\|1490138_1490429_-	hypothetical protein	Q8SDP0	Staphylococcus_virus	2.1e-49	100.0
AXJ30801.1\|1490428_1492012_-\|tail	Prophage endopeptidase tail	Q8SDP1	Staphylococcus_virus	7.1e-309	100.0
AXJ30802.1\|1492020_1492845_-\|tail	Phage tail protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
AXJ30803.1\|1492844_1495322_-	Glycyl-glycine endopeptidase ALE-1 precursor	U5U762	Staphylococcus_phage	0.0e+00	98.3
AXJ30804.1\|1495285_1499044_-	Chromosome partition protein Smc	A0A2I6PDD9	Staphylococcus_phage	0.0e+00	98.5
AXJ30805.1\|1499057_1499216_-	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
AXJ30806.1\|1499257_1499608_-	hypothetical protein	A0A2I6PDE6	Staphylococcus_phage	1.1e-55	100.0
AXJ30807.1\|1499665_1500121_-	Bacterial Ig-like domain (group 2)	A0A2I6PF45	Staphylococcus_phage	1.3e-77	100.0
AXJ30808.1\|1500212_1500854_-\|tail	Phage major tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
AXJ30809.1\|1500888_1501284_-	hypothetical protein	A0A2I6PDD8	Staphylococcus_phage	2.6e-66	100.0
AXJ30810.1\|1501284_1501686_-	hypothetical protein	A0A2I6PDD3	Staphylococcus_phage	6.2e-68	100.0
AXJ30811.1\|1501682_1502015_-	hypothetical protein	A0A2I6PDD6	Staphylococcus_phage	6.2e-58	100.0
AXJ30812.1\|1502026_1502305_-\|head,tail	Phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
AXJ30813.1\|1502373_1503537_-\|capsid	Phage capsid family protein	A0A2I6PDD7	Staphylococcus_phage	9.4e-218	100.0
AXJ30814.1\|1503548_1504322_-\|protease	ATP-dependent Clp protease proteolytic subunit 1	M1TAZ4	Staphylococcus_phage	9.2e-137	100.0
AXJ30815.1\|1504305_1505544_-\|portal	Phage portal protein	A0A2K9VBP0	Staphylococcus_phage	6.9e-235	100.0
AXJ30816.1\|1505548_1507240_-	Phage Terminase	A0A2I6PE44	Staphylococcus_phage	0.0e+00	99.8
AXJ30817.1\|1507229_1507535_-\|terminase	Phage terminase, small subunit	A0A2I6PE27	Staphylococcus_phage	2.9e-49	100.0
AXJ30818.1\|1507663_1507978_-	HNH endonuclease	A0A2I6PDC4	Staphylococcus_phage	2.5e-56	100.0
AXJ30819.1\|1508134_1508572_-	hypothetical protein	A0A2K9VBV2	Staphylococcus_phage	7.9e-77	99.3
AXJ30820.1\|1508584_1509943_-	hypothetical protein	A0A2K9VBW3	Staphylococcus_phage	4.3e-262	100.0
AXJ30821.1\|1509932_1510223_-	VRR-NUC domain protein	A0A2I6PEN7	Staphylococcus_phage	6.5e-51	100.0
AXJ30822.1\|1510563_1513011_-	Virulence-associated protein E	Q4ZCG0	Staphylococcus_virus	0.0e+00	100.0
AXJ30823.1\|1513062_1513263_-	hypothetical protein	A0A2I6PF41	Staphylococcus_phage	2.9e-26	100.0
AXJ30824.1\|1513330_1513483_-	Transcriptional activator RinB	A7TWI2	Staphylococcus_phage	2.6e-19	100.0
AXJ30825.1\|1513479_1513686_-	hypothetical protein	A0A1X9H0C2	Staphylococcus_phage	1.3e-21	100.0
AXJ30826.1\|1513722_1514259_-	dUTPase	A0A1X9H0S5	Staphylococcus_phage	1.4e-96	100.0
AXJ30827.1\|1514251_1514662_-	hypothetical protein	C8CH13	Staphylococcus_phage	2.3e-70	100.0
AXJ30828.1\|1514658_1515192_-	hypothetical protein	A0A1X9H0D4	Staphylococcus_phage	8.5e-81	96.1
AXJ30829.1\|1515188_1515536_-	YopX protein	D2JGL4	Staphylococcus_phage	5.9e-59	100.0
AXJ30830.1\|1515532_1515934_-	hypothetical protein	A0A0N7E0T5	Staphylococcus_phage	7.0e-72	100.0
AXJ30831.1\|1515936_1516143_-	hypothetical protein	A0A0N9BAW9	Staphylococcus_phage	3.0e-34	100.0
AXJ30832.1\|1516156_1516399_-	hypothetical protein	Q8SDR2	Staphylococcus_virus	2.5e-40	100.0
AXJ30833.1\|1516413_1516614_-	hypothetical protein	A0A2I6PF32	Staphylococcus_phage	1.3e-29	100.0
AXJ30834.1\|1516616_1516874_-	hypothetical protein	A0A2I6PF10	Staphylococcus_phage	5.7e-43	100.0
AXJ30835.1\|1516873_1517275_-	PVL ORF-50-like family protein	A0A2I6PF14	Staphylococcus_phage	1.2e-68	100.0
AXJ30836.1\|1517274_1517460_-	hypothetical protein	A0A2I6PEM8	Staphylococcus_phage	7.0e-27	100.0
AXJ30837.1\|1517472_1519434_-	DNA polymerase I, thermostable	A0A2I6PF18	Staphylococcus_phage	0.0e+00	100.0
AXJ30838.1\|1519493_1520051_-	hypothetical protein	A0A2I6PF05	Staphylococcus_phage	1.8e-97	100.0
AXJ30839.1\|1520076_1521243_-	PD-(D/E)XK nuclease superfamily protein	A0A2I6PDL4	Staphylococcus_phage	8.3e-222	100.0
AXJ30840.1\|1521239_1521602_-	hypothetical protein	A0A2K9VBV1	Staphylococcus_phage	6.4e-56	100.0
AXJ30841.1\|1521616_1521940_-	hypothetical protein	A7TWG2	Staphylococcus_phage	2.5e-51	99.1
AXJ30842.1\|1522018_1522180_-	hypothetical protein	A0A2I6PDF7	Staphylococcus_phage	1.2e-19	96.2
AXJ30843.1\|1522191_1522455_-	hypothetical protein	A0A2I6PEL8	Staphylococcus_phage	2.5e-46	100.0
AXJ30844.1\|1522479_1522695_-	hypothetical protein	A0A2I6PDN5	Staphylococcus_phage	5.5e-31	95.8
AXJ30845.1\|1522750_1522981_+	hypothetical protein	A0A2I6PE22	Staphylococcus_phage	1.8e-35	97.4
AXJ30846.1\|1522977_1523154_-	hypothetical protein	B7T0F9	Staphylococcus_virus	1.3e-25	98.3
AXJ30847.1\|1523242_1523434_-	helix-turn-helix protein	A0A2I6PEL6	Staphylococcus_phage	2.3e-28	100.0
AXJ30848.1\|1523594_1523924_+	helix-turn-helix protein	A0A2I6PEN2	Staphylococcus_phage	3.2e-54	100.0
AXJ30849.1\|1523927_1524398_+	hypothetical protein	A0A2I6PEK4	Staphylococcus_phage	5.3e-87	99.4
AXJ30850.1\|1524415_1524850_+	hypothetical protein	A0A2I6PEM0	Staphylococcus_phage	1.2e-24	100.0
AXJ30851.1\|1524878_1525274_+	hypothetical protein	A0A2I6PEJ7	Staphylococcus_phage	1.1e-69	99.2
AXJ30852.1\|1525384_1525510_+	hypothetical protein	A0A2I6PF02	Staphylococcus_phage	5.1e-13	100.0
AXJ30853.1\|1525506_1526121_-	hypothetical protein	A7TW88	Staphylococcus_phage	8.8e-106	99.5
AXJ30854.1\|1526246_1527452_+	Transposase	A0A2I6PEN0	Staphylococcus_phage	7.7e-223	100.0
AXJ30855.1\|1527494_1529489_-	hypothetical protein	B5WZK7	Staphylococcus_phage	4.1e-112	95.8
AXJ30856.1\|1529533_1530442_-	hypothetical protein	NA	NA	NA	NA
AXJ30857.1\|1530686_1532438_-	Sensor protein SrrB	A0A1V0SGX0	Hokovirus	1.7e-21	33.6
AXJ30858.1\|1532418_1533144_-	Transcriptional regulatory protein SrrA	W8CYM9	Bacillus_phage	3.5e-45	43.0

DBSCAN-SWA_5

1591965 : 1600295

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ30922.1\|1591965_1592751_-	High-affinity zinc uptake system ATP-binding protein ZnuC	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
AXJ30923.1\|1592876_1593767_-	putative endonuclease 4	A0A2H4UU70	Bodo_saltans_virus	3.4e-26	36.0
AXJ30924.1\|1593776_1595123_-	DEAD-box ATP-dependent RNA helicase CshB	A0A1V0SIR5	Klosneuvirus	1.8e-55	34.0
AXJ30925.1\|1595236_1596337_-	Putative GTP cyclohydrolase 1 type 2	A0A1S5V250	Saudi_moumouvirus	5.2e-08	29.6
AXJ30926.1\|1596339_1597017_-\|tRNA	tRNA (adenine(22)-N(1))-methyltransferase	NA	NA	NA	NA
AXJ30927.1\|1597147_1598254_-	RNA polymerase sigma factor SigA	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
AXJ30928.1\|1598477_1600295_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.6e-54	36.0

DBSCAN-SWA_6

1668149 : 1677192

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ30998.1\|1668149_1668668_-	Adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
AXJ30999.1\|1668689_1670963_-	Single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.2e-62	28.8
AXJ31000.1\|1671165_1673445_-	bifunctional preprotein translocase subunit SecD/SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
AXJ31001.1\|1673719_1673980_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
AXJ31002.1\|1673998_1675138_-\|tRNA	Queuine tRNA-ribosyltransferase	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
AXJ31003.1\|1675160_1676186_-\|tRNA	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	NA	NA	NA	NA
AXJ31004.1\|1676187_1677192_-	Holliday junction ATP-dependent DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_7

1801708 : 1874849

Staphylococcus_phage(89.09%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ31108.1\|1801708_1808269_-	Extracellular matrix-binding protein ebh precursor	A0A2H4PQU6	Staphylococcus_phage	1.3e-300	97.1
AXJ31109.1\|1808594_1808906_-	molybdopterin biosynthesis-like protein MoeZ	A0A2H4PQR9	Staphylococcus_phage	1.6e-52	100.0
AXJ31110.1\|1808927_1811345_-\|tRNA	Leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.5
AXJ31111.1\|1811632_1812814_-	Multidrug resistance protein MdtH	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
AXJ31112.1\|1812923_1813877_+	coproporphyrinogen III oxidase	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
AXJ31113.1\|1813873_1814437_+	16S rRNA m(4)C1402 methyltransferase	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
AXJ31114.1\|1814556_1814958_-	HTH-type transcriptional regulator rot	NA	NA	NA	NA
AXJ31115.1\|1815529_1816357_-	Phospholipase YtpA	NA	NA	NA	NA
AXJ31116.1\|1816590_1817592_+	Proline dehydrogenase 1	A0A2H4PQT6	Staphylococcus_phage	7.7e-184	99.1
AXJ31117.1\|1817713_1818178_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
AXJ31118.1\|1818190_1819372_-	Riboflavin biosynthesis protein RibBA	A0A2H4PQS2	Staphylococcus_phage	1.5e-226	99.7
AXJ31119.1\|1819382_1820015_-	Riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	6.4e-112	99.0
AXJ31120.1\|1820021_1821053_-	Riboflavin biosynthesis protein RibD	A0A2H4PQS8	Staphylococcus_phage	4.8e-197	99.4
AXJ31121.1\|1821545_1823048_-	hypothetical protein	A0A2H4PQX2	Staphylococcus_phage	2.3e-30	100.0
AXJ31122.1\|1823570_1823885_+	Transcriptional repressor SdpR	A0A2H4PQT4	Staphylococcus_phage	2.0e-53	100.0
AXJ31123.1\|1823884_1825177_+	Arsenical pump membrane protein	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
AXJ31124.1\|1825194_1825590_+	Arsenate-mycothiol transferase ArsC2	A0A2H4PQT9	Staphylococcus_phage	3.1e-72	99.2
AXJ31125.1\|1825884_1826739_-	Bifunctional autolysin precursor	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
AXJ31126.1\|1827014_1827239_-	hypothetical protein	NA	NA	NA	NA
AXJ31127.1\|1827437_1827908_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	8.8e-82	98.1
AXJ31128.1\|1828020_1828464_+	hypothetical protein	NA	NA	NA	NA
AXJ31129.1\|1828450_1828894_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
AXJ31130.1\|1829189_1829825_+\|protease	CAAX amino terminal protease self- immunity	NA	NA	NA	NA
AXJ31131.1\|1830264_1830978_-	Transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
AXJ31132.1\|1831237_1831540_+	hypothetical protein	NA	NA	NA	NA
AXJ31133.1\|1831795_1832161_+	Putative fluoride ion transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
AXJ31134.1\|1832157_1832511_+	Putative fluoride ion transporter CrcB	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	99.1
AXJ31135.1\|1833068_1833323_+	hypothetical protein	A0ZS58	Staphylococcus_virus	2.2e-39	97.6
AXJ31136.1\|1833353_1833848_+	hypothetical protein	Q9MBP7	Staphylococcus_prophage	3.8e-51	92.4
AXJ31137.1\|1833862_1834216_+	hypothetical protein	A0A146ICT8	Staphylococcus_phage	7.3e-65	96.6
AXJ31138.1\|1834234_1834546_+	Transposase DDE domain protein	Q9MBP7	Staphylococcus_prophage	3.6e-47	92.2
AXJ31139.1\|1834608_1835442_-	Glyoxal reductase	A0A2H4PQR8	Staphylococcus_phage	3.5e-158	99.6
AXJ31140.1\|1835653_1836562_-	hypothetical protein	A0A2H4PQQ8	Staphylococcus_phage	1.7e-137	99.0
AXJ31141.1\|1836686_1837880_-	S-adenosylmethionine synthase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
AXJ31142.1\|1838251_1839844_+	Phosphoenolpyruvate carboxykinase [ATP]	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
AXJ31143.1\|1840221_1840992_-	Prolyl oligopeptidase family protein	A0A2H4PQM6	Staphylococcus_phage	1.1e-142	98.8
AXJ31144.1\|1840972_1841452_-	Putative 8-oxo-dGTP diphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.7e-85	100.0
AXJ31145.1\|1841511_1841769_+	Putative membrane protein insertion efficiency factor	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
AXJ31146.1\|1841765_1842767_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	9.0e-185	97.0
AXJ31147.1\|1842771_1844250_-	2-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.8e-283	97.6
AXJ31148.1\|1844408_1844891_-	hypothetical protein	A0A2H4PQN7	Staphylococcus_phage	1.2e-78	98.6
AXJ31149.1\|1845202_1845817_+	SPBc2 prophage-derived endonuclease YokF precursor	A0A2H4PQM8	Staphylococcus_phage	9.5e-36	87.3
AXJ31150.1\|1845897_1846893_+	Telomeric repeat-binding factor 2	A0A2H4PQN2	Staphylococcus_phage	6.2e-77	98.8
AXJ31151.1\|1846968_1847595_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	5.3e-90	93.8
AXJ31152.1\|1847635_1847977_+	hypothetical protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	95.6
AXJ31153.1\|1848077_1848650_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	1.1e-25	96.6
AXJ31154.1\|1848847_1849405_-	hypothetical protein	A0A2H4PQN8	Staphylococcus_phage	3.7e-79	96.8
AXJ31155.1\|1849775_1849952_-	hypothetical protein	NA	NA	NA	NA
AXJ31156.1\|1851059_1851503_-	hypothetical protein	NA	NA	NA	NA
AXJ31157.1\|1851502_1851946_-	hypothetical protein	NA	NA	NA	NA
AXJ31158.1\|1851945_1852389_-	hypothetical protein	NA	NA	NA	NA
AXJ31159.1\|1852813_1855351_+	Hyaluronate lyase precursor	NA	NA	NA	NA
AXJ31160.1\|1855474_1855852_-	hypothetical protein	NA	NA	NA	NA
AXJ31161.1\|1856057_1856498_-	hypothetical protein	NA	NA	NA	NA
AXJ31162.1\|1856542_1858156_+	hypothetical protein	NA	NA	NA	NA
AXJ31163.1\|1858170_1858470_+	hypothetical protein	NA	NA	NA	NA
AXJ31164.1\|1858596_1859832_-	Type I restriction modification DNA specificity domain protein	A0A2H4PQP5	Staphylococcus_phage	6.4e-47	37.2
AXJ31165.1\|1859824_1861381_-	putative type I restriction enzymeP M protein	A0A2H4PQP4	Staphylococcus_phage	3.4e-287	99.0
AXJ31166.1\|1861745_1862465_-\|protease	Serine protease SplF precursor	A0A2H4PQP1	Staphylococcus_phage	1.2e-130	99.2
AXJ31167.1\|1862615_1863332_-\|protease	Serine protease SplE precursor	A0A2H4PQN5	Staphylococcus_phage	3.2e-131	99.6
AXJ31168.1\|1863489_1864209_-\|protease	Serine protease SplD precursor	A0A2H4PQP9	Staphylococcus_phage	4.3e-128	97.9
AXJ31169.1\|1864329_1865049_-\|protease	Serine protease SplC precursor	A0A2H4PQP7	Staphylococcus_phage	3.5e-130	98.7
AXJ31170.1\|1865106_1865829_-\|protease	Serine protease SplB precursor	A0A2H4PQN0	Staphylococcus_phage	1.2e-130	99.2
AXJ31171.1\|1865953_1866646_-\|protease	Serine protease SplA precursor	A0A2H4PQN3	Staphylococcus_phage	1.9e-120	95.7
AXJ31172.1\|1867624_1868194_+	hypothetical protein	A0A2H4PQH6	Staphylococcus_phage	2.6e-51	62.6
AXJ31173.1\|1868665_1868938_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	3.1e-31	81.2
AXJ31174.1\|1869139_1869613_+	hypothetical protein	NA	NA	NA	NA
AXJ31175.1\|1869617_1870409_+	hypothetical protein	NA	NA	NA	NA
AXJ31176.1\|1870778_1871762_-	Leucotoxin LukDv precursor	A0A2H4PQH7	Staphylococcus_phage	1.8e-185	99.4
AXJ31177.1\|1871763_1872699_-	Leucotoxin LukEv precursor	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0
AXJ31178.1\|1873592_1874048_+	hypothetical protein	Q4ZCB9	Staphylococcus_virus	1.7e-61	76.8
AXJ31179.1\|1874060_1874849_+	hypothetical protein	A0A2H4PQI0	Staphylococcus_phage	1.0e-138	95.0

DBSCAN-SWA_8

1998839 : 2005090

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ31288.1\|1998839_1999040_+	Phospholipase C precursor	A0A1P8L6A7	Staphylococcus_phage	3.4e-27	100.0
AXJ31289.1\|2000214_2000565_-	Complement inhibitor precursor	A7TWS0	Staphylococcus_phage	7.5e-54	100.0
AXJ31290.1\|2001247_2001697_+	Chemotaxis inhibitory protein precursor	A7TWR9	Staphylococcus_phage	1.5e-78	100.0
AXJ31291.1\|2001937_2002759_+	Phospholipase C precursor	A0A1P8L6H7	Staphylococcus_phage	5.4e-159	100.0
AXJ31292.1\|2002996_2004013_-	putative leukocidin-like protein 1 precursor	A0A1X9IGW5	Staphylococcus_phage	6.7e-26	30.2
AXJ31293.1\|2004034_2005090_-	putative leukocidin-like protein 2 precursor	A0A1X9IGW5	Staphylococcus_phage	2.8e-35	34.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP022720

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection