CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP022615	Gemella sp. ND 6198 chromosome, complete genome	1 crisprs	cas2,cas1,cas9,cas3,DEDDh,csa3,WYL	2	7	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP022615_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022615_1

125445-126139

TypeII

Consensus_repeat	Method
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CRT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	PILER-CR
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CRISPRCasFinder

10 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of CP022615_1

>merge|CP022615|1|125445-126139|CRT,PILER-CR,CRISPRCasFinder
CTATATTCCGTATTTAACTATACAGTTAACTCAAACAAAATGATTTTTCAGGGGGCATGGGATTTCGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACCAACAGTATCTTAGTTATGACAAAGAAAAAGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACATGTTCCGTACTTTTCAAAAAATCCACGGAGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACTAAAGCTCCTAATGTTTTCTTAAGTTCATTGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACCAATGCTTTTATTTTGTGAATTTAGTAAATGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACAGGATAAAAGGCTTGCTAAGTATATTGAAGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACAGAGATTACTTTTTACAAGGAGAGATTTTAAGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACCGTCATTTTGTTCGTGTTCTACTTTTGATTGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACAACAAAAGTTCAAGGTAAAAGTTCAAAAAGTTTTAGAATACTCAAAATTTACAGTTAACTCAAACAGCTTACGCTCAAATTCTGTACAAGGAATCGTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC

>CP022615|1|1|125445-126139|CRT
CTATATTCCGTATTTAACTATACAGTTAACTCAAAC	AAAATGATTTTTCAGGGGGCATGGGATTTC
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CAACAGTATCTTAGTTATGACAAAGAAAAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	ATGTTCCGTACTTTTCAAAAAATCCACGGA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	TAAAGCTCCTAATGTTTTCTTAAGTTCATT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CAATGCTTTTATTTTGTGAATTTAGTAAAT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGGATAAAAGGCTTGCTAAGTATATTGAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGAGATTACTTTTTACAAGGAGAGATTTTAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CGTCATTTTGTTCGTGTTCTACTTTTGATT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AACAAAAGTTCAAGGTAAAAGTTCAAAAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGCTTACGCTCAAATTCTGTACAAGGAATC
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC

>CP022615|1|1|125511-126139|PILER-CR
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CAACAGTATCTTAGTTATGACAAAGAAAAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	ATGTTCCGTACTTTTCAAAAAATCCACGGA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	TAAAGCTCCTAATGTTTTCTTAAGTTCATT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CAATGCTTTTATTTTGTGAATTTAGTAAAT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGGATAAAAGGCTTGCTAAGTATATTGAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGAGATTACTTTTTACAAGGAGAGATTTTAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CGTCATTTTGTTCGTGTTCTACTTTTGATT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AACAAAAGTTCAAGGTAAAAGTTCAAAAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGCTTACGCTCAAATTCTGTACAAGGAATC
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC

>CP022615|1|1|125511-126139|CRISPRCasFinder
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CAACAGTATCTTAGTTATGACAAAGAAAAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	ATGTTCCGTACTTTTCAAAAAATCCACGGA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	TAAAGCTCCTAATGTTTTCTTAAGTTCATT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CAATGCTTTTATTTTGTGAATTTAGTAAAT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGGATAAAAGGCTTGCTAAGTATATTGAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGAGATTACTTTTTACAAGGAGAGATTTTAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	CGTCATTTTGTTCGTGTTCTACTTTTGATT
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AACAAAAGTTCAAGGTAAAAGTTCAAAAA
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC	AGCTTACGCTCAAATTCTGTACAAGGAATC
GTTTTAGAATACTCAAAATTTACAGTTAACTCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP022615.1\|AXI26037.1\|112820_113540_-\|haloacid-dehalogenase	unknown	unknown	gnl\|CDD\|223943
CP022615.1\|AXI26036.1\|111791_112517_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
CP022615.1\|AXI26052.1\|137501_139868_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|237155
CP022615.1\|AXI26040.1\|115727_117104_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
CP022615.1\|AXI26051.1\|136438_137149_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350157
CP022615.1\|AXI26046.1\|127281_128157_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
CP022615.1\|AXI27414.1\|122883_123867_-\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
CP022615.1\|AXI26048.1\|132724_133951_-\|peptidase-T	unknown	unknown	gnl\|CDD\|235484
CP022615.1\|AXI26041.1\|117373_118528_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|274090
CP022615.1\|AXI27413.1\|121145_122162_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
CP022615.1\|AXI26053.1\|139857_140283_+\|Na(+)/H(+)-antiporter-subunit-B	unknown	unknown	gnl\|CDD\|183602
CP022615.1\|AXI26043.1\|120568_121132_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237622
CP022615.1\|AXI26045.1\|126971_127277_-\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
CP022615.1\|AXI26038.1\|113949_114597_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277353
CP022615.1\|AXI26050.1\|134689_136411_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
CP022615.1\|AXI26049.1\|134081_134582_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|239526
CP022615.1\|AXI26039.1\|114596_115571_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376948
CP022615.1\|AXI26047.1\|128158_132352_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
CP022615.1\|AXI26042.1\|118601_120425_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
CP022615.1\|AXI26044.1\|126300_126975_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09644_csn2_CAS-II-A	gnl\|CDD\|213407

Protein	Function_ID	Function_description	E-value
CP022615.1\|AXI26037.1\|112820_113540_-\|haloacid-dehalogenase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	3.40683e-34
CP022615.1\|AXI26036.1\|111791_112517_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	5.94334e-25
CP022615.1\|AXI26052.1\|137501_139868_+\|sodium:proton-antiporter	gnl\|CDD\|237155	PRK12645, PRK12645, monovalent cation/H+ antiporter subunit A; Reviewed.	0
CP022615.1\|AXI26040.1\|115727_117104_+\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.80006e-73
CP022615.1\|AXI26051.1\|136438_137149_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|350157	cd09006, PNP_EcPNPI-like, purine nucleoside phosphorylases similar to Escherichia coli PNP-I (DeoD) and Trichomonas vaginalis PNP. Escherichia coli purine nucleoside phosphorylase (PNP)-I (or DeoD) accepts both 6-oxo and 6-amino purine nucleosides as substrates. Trichomonas vaginalis PNP has broad substrate specificity, having phosphorolytic catalytic activity with adenosine, inosine, and guanosine (with adenosine as the preferred substrate). This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.40137e-145
CP022615.1\|AXI26046.1\|127281_128157_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.22012e-97
CP022615.1\|AXI27414.1\|122883_123867_-\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.3117e-21
CP022615.1\|AXI26048.1\|132724_133951_-\|peptidase-T	gnl\|CDD\|235484	PRK05469, PRK05469, tripeptide aminopeptidase PepT.	0
CP022615.1\|AXI26041.1\|117373_118528_-\|molecular-chaperone-DnaJ	gnl\|CDD\|274090	TIGR02349, Chaperone_protein_DnaJ, chaperone protein DnaJ. This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.	2.25867e-177
CP022615.1\|AXI27413.1\|121145_122162_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	7.45802e-97
CP022615.1\|AXI26053.1\|139857_140283_+\|Na(+)/H(+)-antiporter-subunit-B	gnl\|CDD\|183602	PRK12573, PRK12573, Na(+)/H(+) antiporter subunit B.	8.09298e-43
CP022615.1\|AXI26043.1\|120568_121132_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237622	PRK14140, PRK14140, heat shock protein GrpE; Provisional.	9.07284e-58
CP022615.1\|AXI26045.1\|126971_127277_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	4.36997e-29
CP022615.1\|AXI26038.1\|113949_114597_+\|hypothetical-protein	gnl\|CDD\|277353	cd07408, MPP_SA0022_N, Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain. SA0022 is an uncharacterized Staphylococcus aureus UshA-like protein with two putative domains, an N-terminal metallophosphatase domain and a C-terminal nucleotidase domain. SA0022 also contains a putative C-terminal cell wall anchor domain. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.22234e-60
CP022615.1\|AXI26050.1\|134689_136411_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
CP022615.1\|AXI26049.1\|134081_134582_-\|acyl-CoA-thioesterase	gnl\|CDD\|239526	cd03442, BFIT_BACH, Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, and brown adipose tissues. The archeal and eukaryotic members of this family have two tandem copies of the conserved hot dog fold, while most bacterial members have only one copy.	1.71918e-20
CP022615.1\|AXI26039.1\|114596_115571_+\|hypothetical-protein	gnl\|CDD\|376948	pfam02872, 5_nucleotid_C, 5'-nucleotidase, C-terminal domain.	7.73113e-42
CP022615.1\|AXI26047.1\|128158_132352_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	3.22664e-106
CP022615.1\|AXI26042.1\|118601_120425_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
CP022615.1\|AXI26044.1\|126300_126975_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213407	cd09644, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	4.45326e-51

>CP022615.1|AXI27414.1|122883_123867_-|IS481-family-transposase
MKTIITENIEKTQRYIPHTLQTRIAAVKTYRNGNSIRFVCRRYKISKASLLRWNKKYDGTKESLIDKSHRPHSIHPNAHTVEELSWIKNLIKRNPNISMIELYAKLKFNKGYKRHPCSLFRVLRKLGFYKDTKKKVIPYKPKPYNTPTEIGKKWQLDVKYVPKRCYVGEIPDKFYQYTIIDEATRERFIFPFKEQSSYSTVQFVKMAIDYFGYKPKIIQTDNGFEFTHFKDTKRIHPFDVLCNNLGIKHQLIRPRTPRHNGKVERSHRNDNERFYRRLSFFSYDDLISQMKKYLYRSNRLPMQTLNWLSPVEKRKELRKESIKICRL
>CP022615.1|AXI27413.1|121145_122162_-|heat-inducible-transcription-repressor-HrcA
MKMLIERQVLILQSIVENFITTNQPIGSKQLAENIDFSSATIRNDMSKLEKEGLIRKTHISSGRVPSEKGYRYYVDYIKKEYELSNSENEKLKELDNDKYVSENNYLEKNAIILSDLTDCTAVILAPTKTDRRINKIEVILLSSRSILVILITSIGEVFQQNYKLDADFTAEDIAEVNKLLQSYFYDVDMATAHVIIHGELEQYLKDKVNNYNMIVVALNRLLQNKIKKTIALGGKYNLLKQPDIDNVDKLKEVVSLLEDDKIVELLDNNSNSEELTSIKIGKELALENIDDLSLVSSKYNTSKGQGIIAVFGPKRMDYSKIMTLISCVRDNLNNNLK
>CP022615.1|AXI26043.1|120568_121132_-|nucleotide-exchange-factor-GrpE
MTTEEQKETLQEEVAEEVVATEKVEEEIAEEKTAEELLQEEVEQLKEEVKNSEDKYLRLYAEFENFKKRKNQEIDTINTYKSQKIITEILPSLDNLERALQLETDNEEVQTVLKGVEMVYEGLQAALKSEGVELVETENAQFDPNIHHAVMQGEDSDKESGMILDTFQKGYKLKDRIIRPAMVKVNS
>CP022615.1|AXI26042.1|118601_120425_-|molecular-chaperone-DnaK
MSKIIGIDLGTTNSCVAVLEGGEAKVIPNPEGNRTTPSVVAFKGDEIQVGEVAKRQAITNPNTVISIKRHMGTDYKEDVNGKKYSPQEISAMILQNLKATAESYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIINEPTAAALAYGLEKTDVDQKVLVFDLGGGTFDVSILELGDGVFEVLATSGDNLLGGDDFDQAIIDYLVAEFKKEQGIDLSQDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFISAGASGPVHLENTLTRAKFDELTHSLVERTLVPTRQALKDAELNPSEIDQVILVGGSTRIPAVQDAVKKEMGKEPHKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGSVMTVLIPRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMATDNKTLGRFQLSDIPPAPRGVPQIEVTFDIDKNGIVNVTAKDLGTQKQQKITIESSSSLTDEDIDRMVKEAEANADADAKRKEEADVRNEADQLSFQADKALEEAKDKVDQSLLDNIKTKNDTLKEAIKNNNLEEIKSAKDELNKAVQEMTMKLYEQANAAAGAQGTDAGATNSKNDDDTIDADFTEKK
>CP022615.1|AXI26041.1|117373_118528_-|molecular-chaperone-DnaJ
MAKRDYYEVLGLSKGASAAEIKKAYRKLSKQYHPDINKEPGAEDKFKEITEAYEVLSDDTKKAQYDQFGHAAFEGGGAGQGGFGGFGGGFSGFSGEFDDLGDIFSSFFGGGSGRRNPNAPRQGEDLLHRIRISFTDAVFGTKKTIKLRKDVECDHCHGTGAKDPSSVTECHRCHGTGQEAVIQDTPFGRIQSQRTCSECGGRGKVIKDKCSHCFGKGYNNREVEYEVEIPEGISSGQRVRLQGKGGVGVNGGPAGDLFIEVIVAEDSYFHREDDDIYTELEISPAQAALGTKIDVRTLTGEIELTVPAGTQHGRKFRLSGKGVKNVMGYGHGDHYIVVSIKIPKNLSSKERELYLELAKLNGEKVEEDESFLDKVSRKAKDLFD
>CP022615.1|AXI26040.1|115727_117104_+|ISL3-family-transposase
MNNFNTKTKEIKEGEFIKNLLQIKDKNITIEKTHNETIKNNQKYFVFKGTLTYKPKKCECCGCLNKGYTVVKNGFNELTRINLLKISGIPAYLELRKQRFKCKTCNKKFVATTSFVDKYCSISKNVKFSIMSDLADTLSFKQIAKMNNVSVNTVIRTLYKCKSHVDILNYNTLPEYLCFDELKFTKDSKNGMSFIFLDALTHEIIDIVDGRTEYILNNYFSRFSKEARSNVKAICIDIYTPYMKLIRNKFPNAEIVIDRFHIIQNVNRELNRTRVKLMNIYKKQKGINYTLLKNNWKLILEDESNVTHGRFFFNRSFRSLVTRRDILDYLLGLDCIFKASYERVQDIRYAIRYRNELEFKELIEKSTIDLSDGVSKAINTMRKHKGYMLNSVRYSISNGSLEGINNKIKVLKRVSYGYNSFYNFRLRILVVSRLFVSEYKNNISFKGVLKNAKQHCIA
>CP022615.1|AXI26039.1|114596_115571_+|hypothetical-protein
MPNADVEKIVKAAQAEFDKKGSVVVIDKAPYTLEGTSENVRTKETNLGNLIADALYNAKVFKHESDFAVTNGGGIRTTLKKDSPITVGDIIKAMPFGNQLTQIQVKGTDVKKMYEHSLRALINTDNDGKEILDAQGKPQLGSNGGFLQSSSSVKVGFDPHKKPGERVYSIEILNKQTGKFEPLDLQKTYYMATNDFLAVGGDGYTMLGGAREEGGATMDSIVVEYLKQLTNEQFLQYKDPFPYSRIIPGVKSTEPVNPGKDDDLKTPPTNDHSKENKKFGSGKQPTKDNVRKLPNTGIATDTTTVGVGLLLATSLLMTRRKNEK
>CP022615.1|AXI26038.1|113949_114597_+|hypothetical-protein
MMKLKSSKIVTFLLTFIILISQIFTGSFAFANNANNINDKVPFTIFHTNDMHGRLAYEEYKGTPSSYGSAREKTLIDNEKQNNSERTVIALDAGDAFQGLPISNQSKGEDMAKAMNKIGYKAMTAGNHEFDFGLDTVEKYKNNTNNGGWLNFPIVSTNVYKNGQRLFKPSTIITEKGVKIGIVGVTTPETATKTNPVGIKGVTFTKPIPEIMLKT
>CP022615.1|AXI26037.1|112820_113540_-|haloacid-dehalogenase
MFGDIKNIIFDLDNTLYHFSSIWKESNERTFNYFGYNNFINYEDFFLKYKEVNNELIKKIRSGELRFKELRFERLITTFEKFEISLTNDDCKVYYEKQFEFINDLIVPDIELIDKIKDLKRQYNLVILTNGKALEQRQKIKKLGLENLFKLYISEETHISKPKPDAFINILEENDFLPEETLMIGDSIFYDIKPAKKLGCRTCLIDRRWHFDDEGKNLNYDGYKAYDVKIVLDNLLKKI
>CP022615.1|AXI26036.1|111791_112517_-|rhodanese-like-domain-containing-protein
MKKHKLLAISMATLLSFTLAGCSKSSSNQSSTDGNATVKDMKGEELNKIEKDDKEKEKYLVIDVRDAKEYNEGHVKHAINIPVGDIEKNVDRLSAWKDKKVVTVCNTGKKSKEAAEKLVKAGFKDVTNAQGVKDYKDYEISKFTTLLADDFQKAIDEKKGQFIDARDSKDYDKKHIEGAINVDSKKLDDLEAKLPKDKEAPIYTYCYSGNRSSVVAKKLTELGYKNVFNAFDGVKEHEYKF
>CP022615.1|AXI26044.1|126300_126975_-|type-II-A-CRISPR-associated-protein-Csn2
MKIVNREWQRSIELKENIINTIILENKQYFRECVRSLKLQHQGDEGLFIFSDGLKEISLAKYSYLITDLFNLDINNKKILTKIYTELMKYAVENYIELNTIQTNLLNYYENLIHSSSLELEYRDELDIMGMLKLADFKINLISNNDLEKLIKYLKVLVELCGIKVIFIVGLHIYYTENEIKQLYKELCINKIKIINIENQQYKNLSTVDYTEKVYIFDEENCEI
>CP022615.1|AXI26045.1|126971_127277_-|CRISPR-associated-endonuclease-Cas2
MRILVMFDLPTETSEQRKNYRKFRKNLIKTGFIMMQESVYVKLSMNQNSTDLVIKSIRKYCPDEGIVQILTVTEKQFSKMEFLVGESQNEYVDSDERFIEL
>CP022615.1|AXI26046.1|127281_128157_-|type-II-CRISPR-associated-endonuclease-Cas1
MSWRTIVIRDRAKLDYSLNFMTVRKENETKKICLNEIYMLIIESTAVSITAVLLNELNKNKVKVLFCDEKRNPSSELISLYGSHDTSLKYRKQMEWSNKIKAHVWTRIVYEKIYNQMQFLKKLGKNEHKLLELYLSELGYNDESNREGHAAKVYFNALYGMDFSRNKECFVNSCLDYGYAIILSAFNREIAASGYCTQLGICHRNIFNKFNLASDFMEPFRILIDEEVYSYTETEFTKEHKNRLVNILNRTICIENKNQTVANAIKIYCQSLFNALNDSDLEYIKMYKYEL
>CP022615.1|AXI26047.1|128158_132352_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MNENKEWFLGLDIGTASVGWAATDTNYNLLKLKGKKSWGVRLFDEAQTAKERRDCRSKRRRLARRKWRLGLLEELFAEEINKIDPNFFMRLRESKYKVGDKTENVPSILFNDKNYTDKEYYRDYKTIYHLRADLIHKNNPDIRELFLAIHHILKYRGHFLFAGQQFKGSEIKDNIRELLQYNSLNIKIDITDELINNIAEILLKKKNSTDKIIEFKKLFADEKQLIEALRLALGNKTQLAKLFDIEAYKELDISIKTISFKEKIYEDVRSNYEEILGEYIIVLDTAKLIYDAIILSEIKIKNMTISESKVISYEKHGKDLKQLKQLIKEDSKLSKKEKRQLFENIFVKEDEKEANYVNYIGKNNVGSSKSSCSYEDFKKSLIKELKYCEESKLKQDILAELELETFLPRQRTKDNSVIPYQIHKEELEKILNNAVQYHPFLNNTDEYGISIKEKIIQLLEFRIPYYVGPLNTSHKVGNGGFSWSVRNKGYERTAVTPWNFNKVINKEESAKNFIENLTNQCTYLLYEDVLPKHSLLYSEFTLLNELNSINYGGKRLTVEHRNLIIERFFKQSAPKATGKELKKFLMSEGVIDGKDELSGFDISIKNDLKSYRDFKKILGEKFDSEKVEKMIRWITLFGESKQLLADKITKEYGDIYSSEEIKKISGLTYKDWGRLSEKLLTEIVSSQLYDESTGECFNIINAMRNNTLLFIELLGTNYDYFEKINTYNGKLRKEITEITPHILDDLYVSPAVKRSIWQVVRIVEELKKVIGSEPKRIFVETTRSNKEKKGDDGRKDSRKKALLELYKKIKTSDIAELEKALGHTVDFDKKKQDLTDIDNNKLKARKLYLYYTQLGRCLYTGKAIDLNNLFGSNSEYDIDHIYPQSKTKDGSWNNLVLVNKTENSKKSNGLISESIQRKNKHFWRFLKAKNLISEEKYKRLTRTEDFTDGELSGFIARQLIETSQSVKVVSKILQNLNPTTELCFSKAENVSDFRQEFGKIKVGKRKNLTEEEQKKAKEGQLIKVRDLNDLHHAKDAYLNIVVGNVYHIKFTRNPKNFIRKNFKNREYTLNTLFYSDKVERNGEVAWEKGKTEEIVSSVMCNNLINVTRRTSEQKGALYEATIYKANAAKEGSYYPVKTNNKNLKNVTRYGGFTSIKIAYYSIFKYDIRNKDKVKENIKIIPIPIYISQNIKTDLDLINFAEKQIKLKKGENIENLQLIYKKLNIGALVKIDHYPYYIGGKTDDNFYVDGAVQVLLSSDIERYLKEVVKFVNFQRENKEAKVSKEYISLEENIKLYNTLVCKMATKIFTHKKNNKYNDLTQDKAKNTFNKLSLEEQCKVLLEILNLLTNKKTTFDLSLINEKTSRVKCGFNLLNQKQFSIIEQSVTGLYEKEIKIIED
>CP022615.1|AXI26048.1|132724_133951_-|peptidase-T
MKYETMLERFLGYVKFKSRSDSGSTTIPSTPEQKDFLRMLKGQLEELNLSDIVLNEKNWFLTATLPANTDKPYDTIGFISHVDTADFNVEGISPRVIENYSGEDIVLNKEKNIIMTMAEFPNLKNYKDLTLITTDGTTLLGADDKAGITEIVEAVKYLSEHREIEHGDIRIAFGPDEEIGRGADHFDAKGFATDYAYTMDGSVLGELQYESFNAAQITYKITGVSVHPGTAKGKMKNANMIAVELASLFPEKEVPEHTEDYEGFYLLHNMQTRIEEAELVYIIRDHDREKFLARKAFCESVAAKINEKYGNVVEYELFDQYYNMGDVIKEDKRCVDVAEQAIKNVGVVPIIIPIRGGTDGSKISYMGIPTPNIFVGGENFHGQYEFSCLEHMKKAADVIVEIAKLAKK
>CP022615.1|AXI26049.1|134081_134582_-|acyl-CoA-thioesterase
MTTVLNYKDTMIENFHTIYPNHMNRHDTLFGGQTLYWLDDVQGLVIRRYTHLPFFTASIDTYQFLDVVHRHEALIIRSYISRVGTRSVEIFAELSAFNHETRKTRLVGICFSTFAINRETKLEEPLPQVEYTDEISKFVSSSYSDRQSGKLTAREFCKEYLKYYNR
>CP022615.1|AXI26050.1|134689_136411_-|phospho-sugar-mutase
MSNYKELYDKWLNSSVLTDEERKQLVDIANNEEEKEDRFYKELEFGTAGLRGKVGMGSNRMNRFIIARATKALAQTIIDNGLQDKGIAIAHDPRLFSKEFAKLAALVMASNGVKAYLFEDLRPTPELSFTIRYLKTASGINITASHNPKEYNGYKVYWQEGSQIKSNISDKVLEYINSMDIFDNYVTLTEEEAIKKGLLIYIGKEIDEKFYKESLDCAINDDNIDKGISVVYTPLNGAGYKAVTTVLAHRGFNNVYVVEEQKDPDGTFPTIEYPNPEDTAAFEYGERLAKKVDADILIATDPDCDRLAVEVVHDGEIISFNGNQTGAVLVQYVIENLAKQGKLPKNPALVKSIVTSKMVEPLCSEYGVEVIDVLTGFKNICALPNEWDTTAEKNYVMGYEESIGYNVGTFLRDKDGVTIAMLLVEAAAFYKKQGKTLVDVLDEFYKKYGYYLDKTISIVLEGASGAKRIKRMMEQYREIFAREIAGSKVAVVTDYLTQKEKIVATGEEKDITIEKTDAVKFSYDDESWYTLRPSGTEPKIKLYIYVKADDKSVAEEKLVKFEEKVLELLYSIK
>CP022615.1|AXI26051.1|136438_137149_-|purine-nucleoside-phosphorylase
MSNKQTPHIKPNGVEIAETVLLPGDPLRAKFIAENFLEDAVCFNEVRGMLGYTGTYKGKKVSVMGTGMGPASIGIYSYELIHVFGVKNLIRIGTCGALQKNIKLYDVILGMGSSTNSNYMHQYNIPGELSLTASFDLLLKAYNKAQEMGQPVHVGNILCSEIFYNSDKNAMENWIKMGVLAVEMESTALYANAIAAGVNALTILTVSDSLVTGEETTPEERQTAFTKMMEIALNLA
>CP022615.1|AXI26052.1|137501_139868_+|sodium:proton-antiporter
MLQLTVFLPVIVMFFIPTIRKNFKTIHLGKVVVIVPLVLFGYFLSQLKNIYSGGIVYKSLAFATNVGLDINFKLDGLSLLFTLLITGIGTLVILYSCYYMDINDPKLHKFYIFLLIFMSAMLGVVLSDNLLSMYMFWELTSVSSFLLISYWHENDASRKGALKSLIITVFGGVLMLLGIFILNNVTGSFNISEIITFSQNNKYTSKYIPAMILILFGAFTKSAQFPFHIWLPDAMAAPTPISSYLHSATMVKAGIYLLLRVGIIFSFSASFGNILIIFGTLTMLIGSISAIFLKDLKGILAYSTISQLGMMTLMIGIANLGLYDKNHYIYTFAFYAVCFHIINHAAFKACLFMITGIIDHTFHTRDVNKLRGIRAYLPISFILSIIAGFSMAGIPPLSGFFSKEYFLTSVYGLISTSSLYIIIAILVVIASLGTFIYSFILIFKPFLGTFNKTFSNETKIHLPDKKITVAPVILAVFVIINSFIKDYIIIPAQNAALAGDVTNNKIISHISHDNFLSKELITTILVVLIGIFIYKTFAAKNIIYKYNPSIISIHRLYNSLGTKLHAGAGYLHNKFITNELKRNMSYIFLSLSITILAGYVAVGKPIIINSFSSVHIMNIIIGICIVICCIAMARCYNRLVLIILSSGVSFMMTALYVTFRAPDLAMTQFVIESISTIIFLIAFILLTNKTKHVEKQKFKLTNAIIAGLTGISFITVGLVSYAYKNPSAISQFYFDNVVSSGGGNIVNVIIVDFRGFDTLFEITVMTMVALIIYAMFKIIKRGGNKDEN
>CP022615.1|AXI26053.1|139857_140283_+|Na(+)/H(+)-antiporter-subunit-B
MKTNDLILKSLSAIISSCIFLLSLSLYFGGHFLPGGGFVGGLLCTMALALSMFTYGIKRVTKLLPINYIYVTAIGLLFSVGTAFSGIVTGENFFKHHFTHIHVPLMGEMELHTAAIFDLGVYLIVVGVLMSVILAFGKDGK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP022615_1	1.7\|125876\|31\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125876-125906	31	CP022615.1	241977-242007	0	1.0
CP022615_1	1.5\|125745\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125745-125774	30	CP022615.1	1669325-1669354	1	0.967

1. spacer 1.7|125876|31|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to position: 241977-242007, mismatch: 0, identity: 1.0

agagattactttttacaaggagagattttaa	CRISPR spacer
agagattactttttacaaggagagattttaa	Protospacer
*******************************

2. spacer 1.5|125745|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to position: 1669325-1669354, mismatch: 1, identity: 0.967

caatgcttttattttgtgaatttagtaaat	CRISPR spacer
caatacttttattttgtgaatttagtaaat	Protospacer
****.*************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP022615_1	1.7\|125876\|31\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125876-125906	31	JN638751	Bacillus phage G, complete genome	144052-144082	6	0.806
CP022615_1	1.9\|126009\|29\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	126009-126037	29	MH552532	Siphoviridae sp. isolate ctbf3, complete genome	50086-50114	6	0.793
CP022615_1	1.4\|125679\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125679-125708	30	AP014352	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C33, * SEQUENCING IN PROGRESS *	16423-16452	7	0.767
CP022615_1	1.5\|125745\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125745-125774	30	NZ_CP027438	Escherichia coli strain 2012C-4221 plasmid unnamed1, complete sequence	60439-60468	7	0.767
CP022615_1	1.5\|125745\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125745-125774	30	MK448815	Streptococcus phage Javan585, complete genome	2960-2989	7	0.767
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	MK798156	Enterococcus hirae strain fas4 plasmid pfas4-2, complete sequence	19056-19085	7	0.767
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	NZ_CP013981	Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence	21275-21304	7	0.767
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	8644-8673	7	0.767
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	3903-3932	7	0.767
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	NC_009130	Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence	38030-38059	7	0.767
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	20082-20111	7	0.767
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP012102	Bacillus thuringiensis strain HS18-1 plasmid pHS18-3, complete sequence	16005-16034	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP012106	Bacillus thuringiensis strain HS18-1 plasmid pHS18-7, complete sequence	3044-3073	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP020868	Campylobacter cuniculorum DSM 23162 = LMG 24588 plasmid pCUN1, complete sequence	679-708	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP053969	Bacillus thuringiensis strain FDAARGOS_796 plasmid unnamed1, complete sequence	16040-16069	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NC_007106	Bacillus cereus E33L plasmid pE33L8, complete sequence	1597-1626	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP040338	Bacillus luti strain FJ plasmid unnamed2, complete sequence	5921-5950	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP040338	Bacillus luti strain FJ plasmid unnamed2, complete sequence	18100-18129	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP013281	Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-6-16K, complete sequence	11908-11937	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NC_011771	Bacillus cereus AH820 plasmid pAH820_10, complete sequence	7398-7427	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP009970	Bacillus cereus E33L plasmid pBCO_4, complete sequence	7022-7051	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP021438	Bacillus thuringiensis strain C15 plasmid pBMB172, complete sequence	79172-79201	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP021439	Bacillus thuringiensis strain C15 plasmid pBMB22, complete sequence	22600-22629	8	0.733
CP022615_1	1.3\|125613\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125613-125642	30	NZ_CP015325	Bacillus filamentosus strain Hbe603 plasmid pBEH3, complete sequence	39814-39843	8	0.733
CP022615_1	1.5\|125745\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125745-125774	30	NZ_CP013043	Clostridium perfringens strain JP55 plasmid pJFP55H, complete sequence	47566-47595	8	0.733
CP022615_1	1.7\|125876\|31\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125876-125906	31	NC_049942	Escherichia phage JLK-2012, complete sequence	1591-1621	8	0.742
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	NZ_CP015254	Bacillus thuringiensis Bt18247 plasmid p81952, complete sequence	63309-63338	8	0.733
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	20367-20396	9	0.7
CP022615_1	1.2\|125547\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125547-125576	30	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	20407-20436	9	0.7
CP022615_1	1.8\|125943\|30\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125943-125972	30	KC465899	Pelagibacter phage HTVC008M, complete genome	100847-100876	9	0.7
CP022615_1	1.7\|125876\|31\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125876-125906	31	KX171213	Staphylococcus phage vB_SscM-2, complete genome	90047-90077	10	0.677
CP022615_1	1.7\|125876\|31\|CP022615\|CRT,PILER-CR,CRISPRCasFinder	125876-125906	31	NC_047767	Staphylococcus phage vB_SscM-1, complete genome	90046-90076	10	0.677

1. spacer 1.7|125876|31|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to JN638751 (Bacillus phage G, complete genome) position: , mismatch: 6, identity: 0.806

agagattactttttacaaggagagattttaa	CRISPR spacer
aaaaatggctttttacaaggagaaatattaa	Protospacer
*.*.** .***************.** ****

2. spacer 1.9|126009|29|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to MH552532 (Siphoviridae sp. isolate ctbf3, complete genome) position: , mismatch: 6, identity: 0.793

aacaaaagttcaaggtaaaagttcaaaaa	CRISPR spacer
ctaaaaagttcaatgtaaaagttgaaaag	Protospacer
   ********** ********* ****.

3. spacer 1.4|125679|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to AP014352 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C33, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

taaagctcctaatgttttcttaagttcatt	CRISPR spacer
tcactctcctaattttttcttaagttctaa	Protospacer
* *  ******** *************

4. spacer 1.5|125745|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP027438 (Escherichia coli strain 2012C-4221 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

caatgcttttattttgtgaatttagtaaat	CRISPR spacer
taatgctttttttttgtgaatttttactat	Protospacer
.********* ************     **

5. spacer 1.5|125745|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to MK448815 (Streptococcus phage Javan585, complete genome) position: , mismatch: 7, identity: 0.767

caatgcttttattttgtgaatttagtaaat-----	CRISPR spacer
caatgcttttattttttgaatt-----agtcttta	Protospacer
*************** ******     *.*

6. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to MK798156 (Enterococcus hirae strain fas4 plasmid pfas4-2, complete sequence) position: , mismatch: 7, identity: 0.767

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
caccattttgttcttgttctactattccta	Protospacer
*..********** ********* **  *

7. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP013981 (Staphylococcus equorum strain KM1031 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
caccattttgttcttgttctactattccta	Protospacer
*..********** ********* **  *

8. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
caccattttgttcttgttctactattccta	Protospacer
*..********** ********* **  *

9. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
caccattttgttcttgttctactattccta	Protospacer
*..********** ********* **  *

10. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NC_009130 (Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence) position: , mismatch: 7, identity: 0.767

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
caccattttgttcttgttctactattccta	Protospacer
*..********** ********* **  *

11. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 7, identity: 0.767

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
caccattttgttcttgttctactattccta	Protospacer
*..********** ********* **  *

12. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP012102 (Bacillus thuringiensis strain HS18-1 plasmid pHS18-3, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
atattacttcttagttatgaaaaagaaaaa	Protospacer
  *. .. ************ *********

13. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP012106 (Bacillus thuringiensis strain HS18-1 plasmid pHS18-7, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagttatgacaaaaaaaat	Protospacer
 .. * ** ***************.****

14. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP020868 (Campylobacter cuniculorum DSM 23162 = LMG 24588 plasmid pCUN1, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
tttaaaaatcttacttatgagaaagaaaaa	Protospacer
.   *. ****** ****** *********

15. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP053969 (Bacillus thuringiensis strain FDAARGOS_796 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

16. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NC_007106 (Bacillus cereus E33L plasmid pE33L8, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

17. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP040338 (Bacillus luti strain FJ plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

18. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP040338 (Bacillus luti strain FJ plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

19. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP013281 (Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-6-16K, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

20. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NC_011771 (Bacillus cereus AH820 plasmid pAH820_10, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

21. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP009970 (Bacillus cereus E33L plasmid pBCO_4, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

22. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP021438 (Bacillus thuringiensis strain C15 plasmid pBMB172, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

23. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP021439 (Bacillus thuringiensis strain C15 plasmid pBMB22, complete sequence) position: , mismatch: 8, identity: 0.733

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
aggaattaacttagatatgacaaagaaaat	Protospacer
 .. * ** ***** **************

24. spacer 1.3|125613|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP015325 (Bacillus filamentosus strain Hbe603 plasmid pBEH3, complete sequence) position: , mismatch: 8, identity: 0.733

atgttccgtacttttcaaaaaatccacgga	CRISPR spacer
cttttccgtacgtttcaaaatatccaaatg	Protospacer
 * ******** ******** ***** . .

25. spacer 1.5|125745|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP013043 (Clostridium perfringens strain JP55 plasmid pJFP55H, complete sequence) position: , mismatch: 8, identity: 0.733

caatgcttttattttgtgaatttagtaaat	CRISPR spacer
aaatgctttttatttgtgaatttatctgaa	Protospacer
 *********  ************ . .*

26. spacer 1.7|125876|31|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 8, identity: 0.742

agagattactttttacaaggagagattttaa	CRISPR spacer
aggatttacttttcgcaaggagagatttgtt	Protospacer
**.. ********..*************

27. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP015254 (Bacillus thuringiensis Bt18247 plasmid p81952, complete sequence) position: , mismatch: 8, identity: 0.733

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
tttcattttgttcttgttctactaacattt	Protospacer
. *********** *********  .. **

28. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 9, identity: 0.7

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
ttcttatatcttagttttggcaaagaaaac	Protospacer
.  . .********** **.*********

29. spacer 1.2|125547|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 9, identity: 0.7

caacagtatcttagttatgacaaagaaaaa	CRISPR spacer
ttcttatatcttagttttggcaaagaaaac	Protospacer
.  . .********** **.*********

30. spacer 1.8|125943|30|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to KC465899 (Pelagibacter phage HTVC008M, complete genome) position: , mismatch: 9, identity: 0.7

cgtcattttgttcgtgttctacttttgatt	CRISPR spacer
tctccttttgttcgttttctactttaatca	Protospacer
. ** ********** ********* . .

31. spacer 1.7|125876|31|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to KX171213 (Staphylococcus phage vB_SscM-2, complete genome) position: , mismatch: 10, identity: 0.677

agagattactttttacaaggagagattttaa	CRISPR spacer
gagcattactttttacacggagagatagact	Protospacer
... ************* ********

32. spacer 1.7|125876|31|CP022615|CRT,PILER-CR,CRISPRCasFinder matches to NC_047767 (Staphylococcus phage vB_SscM-1, complete genome) position: , mismatch: 10, identity: 0.677

agagattactttttacaaggagagattttaa	CRISPR spacer
gagcattactttttacacggagagatagact	Protospacer
... ************* ********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

610116 : 618306

Streptococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXI26443.1\|610116_610815_+	capsular biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	3.9e-41	42.8
AXI26444.1\|610824_611520_+	tyrosine protein kinase	A0A1X9I5D6	Streptococcus_phage	3.3e-53	49.3
AXI26445.1\|611544_612906_+	hypothetical protein	NA	NA	NA	NA
AXI26446.1\|613120_614188_+	glycosyltransferase	A0A1G5SA08	Enterococcus_phage	8.8e-21	29.2
AXI26447.1\|614199_615063_+	LicD family protein	A0A1V0SAS8	Catovirus	1.7e-06	43.4
AXI26448.1\|615043_615901_+	LicD family protein	A0A1V0SD50	Indivirus	1.4e-05	40.7
AXI26449.1\|615893_616967_+	alanine--glyoxylate aminotransferase family protein	NA	NA	NA	NA
AXI26450.1\|616980_618306_+	glycerol-3-phosphate cytidylyltransferase	A0A0F7LBI5	uncultured_marine_virus	4.8e-08	32.8

DBSCAN-SWA_2

1037649 : 1088184

Erysipelothrix_phage(43.9%)

capsid,portal,terminase,head,tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXI26745.1\|1037649_1037928_+	hypothetical protein	S5M5X1	Brevibacillus_phage	1.4e-07	58.8
AXI26746.1\|1037920_1039060_+	DUF2800 domain-containing protein	A0A2K5B2A8	Erysipelothrix_phage	4.5e-164	74.6
AXI26747.1\|1039061_1039610_+	DUF2815 domain-containing protein	A0A2K5B2A9	Erysipelothrix_phage	3.4e-85	83.6
AXI27445.1\|1039779_1041777_+	hypothetical protein	A0A2K5B2B0	Erysipelothrix_phage	5.5e-274	69.2
AXI26748.1\|1041993_1042668_+	transcriptional regulator	A0A2K5B268	Erysipelothrix_phage	3.1e-80	61.8
AXI26749.1\|1042660_1043038_+	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	3.4e-28	53.0
AXI26750.1\|1043024_1045298_+	DNA primase	A0A1B0RXC5	Streptococcus_phage	1.1e-47	38.6
AXI26751.1\|1045485_1045815_+	hypothetical protein	NA	NA	NA	NA
AXI26752.1\|1045792_1046086_+	VRR-NUC domain-containing protein	A0A1X9I6B2	Streptococcus_phage	9.2e-21	54.4
AXI26753.1\|1046063_1046540_+	HNH endonuclease	NA	NA	NA	NA
AXI27446.1\|1046532_1047864_+	ATP-dependent helicase	A0A2K5B273	Erysipelothrix_phage	2.1e-165	71.3
AXI26754.1\|1047912_1048347_+	DUF1492 domain-containing protein	A0A2K5B275	Erysipelothrix_phage	1.8e-33	50.7
AXI26755.1\|1048515_1048875_+	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	1.7e-37	58.0
AXI26756.1\|1048983_1049580_+\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	3.9e-42	46.4
AXI26757.1\|1049585_1050368_+	S-adenosylmethionine synthetase	NA	NA	NA	NA
AXI26758.1\|1050380_1051643_+	DNA modification methylase	A0A2I4R670	Erysipelothrix_phage	1.1e-115	49.1
AXI26759.1\|1051623_1053216_+	DNA (cytosine-5-)-methyltransferase	A0A1P8DJM9	Virus_Rctr41k	3.1e-30	37.1
AXI26760.1\|1053290_1053929_+	virulence protein	A0A2K5B280	Erysipelothrix_phage	3.6e-46	48.2
AXI26761.1\|1053930_1054161_+	DUF4314 domain-containing protein	A0A2K5B281	Erysipelothrix_phage	1.6e-20	65.7
AXI26762.1\|1054150_1054324_+	DUF5049 domain-containing protein	NA	NA	NA	NA
AXI26763.1\|1054430_1054676_+	hypothetical protein	NA	NA	NA	NA
AXI26764.1\|1054677_1054956_+	hypothetical protein	NA	NA	NA	NA
AXI26765.1\|1055044_1056637_+\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	5.7e-266	83.4
AXI26766.1\|1056763_1056973_+	hypothetical protein	NA	NA	NA	NA
AXI26767.1\|1057039_1058368_+\|portal	phage portal protein	A0A2K5B287	Erysipelothrix_phage	1.4e-172	71.2
AXI27447.1\|1058318_1059026_+	peptidase	Q6DMU1	Streptococcus_phage	1.9e-64	63.5
AXI26768.1\|1059031_1060225_+\|capsid	phage major capsid protein	M1Q1R5	Streptococcus_phage	5.0e-105	49.6
AXI26769.1\|1060243_1060522_+\|head,tail	phage gp6-like head-tail connector protein	A0A1B0RXE3	Streptococcus_phage	7.4e-12	44.6
AXI26770.1\|1060621_1060954_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
AXI26771.1\|1060950_1061331_+	hypothetical protein	Q6DMT7	Streptococcus_phage	1.3e-14	39.3
AXI26772.1\|1061323_1061656_+	hypothetical protein	M1Q1Z4	Streptococcus_phage	1.0e-20	44.4
AXI26773.1\|1061645_1062236_+\|tail	phage tail protein	A0A0U4JWV5	Exiguobacterium_phage	6.6e-42	50.0
AXI26774.1\|1062247_1062613_+	hypothetical protein	A0A2H4JAG8	uncultured_Caudovirales_phage	7.7e-09	36.0
AXI26775.1\|1062851_1063469_+	phosphomethylpyrimidine kinase	NA	NA	NA	NA
AXI26776.1\|1063569_1066395_+\|tail	phage tail tape measure protein	Q6DMT2	Streptococcus_phage	1.8e-57	27.6
AXI26777.1\|1066397_1067069_+	hypothetical protein	A0A2K9V3E8	Faecalibacterium_phage	9.8e-18	32.5
AXI26778.1\|1067069_1069895_+	hypothetical protein	H7BV46	unidentified_phage	4.2e-118	31.0
AXI26779.1\|1069906_1070089_+	hypothetical protein	NA	NA	NA	NA
AXI26780.1\|1070069_1070351_+	toxin	NA	NA	NA	NA
AXI26781.1\|1070363_1070660_+	hypothetical protein	NA	NA	NA	NA
AXI26782.1\|1070659_1070872_+	hypothetical protein	NA	NA	NA	NA
AXI26783.1\|1070885_1071479_+	hypothetical protein	NA	NA	NA	NA
AXI26784.1\|1071488_1072007_+	hypothetical protein	NA	NA	NA	NA
AXI26785.1\|1072008_1072419_+\|holin	holin	A0A2K5B2A2	Erysipelothrix_phage	5.2e-46	67.6
AXI26786.1\|1072411_1073398_+	lysozyme	A0A2K9V338	Faecalibacterium_phage	7.1e-49	54.9
AXI26787.1\|1073571_1073982_+	helix-turn-helix domain-containing protein	A0A1B0RXK7	Streptococcus_phage	4.9e-20	42.9
AXI26788.1\|1073968_1074181_+	hypothetical protein	NA	NA	NA	NA
AXI26789.1\|1074242_1075808_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	3.4e-138	49.0
AXI26790.1\|1075804_1076215_+	hypothetical protein	A0A2K5B2B3	Erysipelothrix_phage	3.7e-20	38.2
AXI26791.1\|1076217_1077801_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	8.8e-150	61.0
AXI26792.1\|1078560_1079496_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	7.7e-170	99.0
AXI26793.1\|1079770_1079857_+	tetracycline resistance protein	NA	NA	NA	NA
AXI26794.1\|1079872_1081792_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	99.1
AXI26795.1\|1081892_1082078_+	conjugal transfer protein	D0R0F6	Streptococcus_phage	3.9e-17	67.9
AXI26796.1\|1082137_1082491_-	XRE family transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
AXI26797.1\|1083318_1084746_+	ABC transporter	G9BWD6	Planktothrix_phage	2.0e-12	29.0
AXI26798.1\|1084732_1086451_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	6.8e-39	28.1
AXI26799.1\|1086447_1088184_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	9.0e-31	26.1

DBSCAN-SWA_3

1442882 : 1454447

Synechococcus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXI27092.1\|1442882_1446557_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	3.4e-27	30.3
AXI27093.1\|1446558_1447266_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	6.0e-42	40.7
AXI27094.1\|1447252_1448719_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.2e-46	32.4
AXI27095.1\|1448702_1449707_+	phosphoribosylformylglycinamidine cyclo-ligase	M4QRQ6	Synechococcus_phage	5.7e-62	42.1
AXI27096.1\|1449703_1450267_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	3.1e-25	36.9
AXI27097.1\|1450263_1451784_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH	Q58MG4	Prochlorococcus_phage	6.8e-67	46.8
AXI27098.1\|1451786_1453022_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
AXI27099.1\|1453142_1454447_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.8e-18	30.9

DBSCAN-SWA_4

1602668 : 1653022

Streptococcus_phage(16.67%)

protease,transposase,capsid,portal,terminase,head,tRNA,tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXI27224.1\|1602668_1605293_-\|tRNA	alanine--tRNA ligase	A0A2K9L3D8	Tupanvirus	3.4e-66	35.1
AXI27469.1\|1605710_1606694_+\|transposase	IS481 family transposase	A8RHK4	Spiroplasma_virus	7.9e-08	31.2
AXI27225.1\|1606947_1607319_-	general stress protein	NA	NA	NA	NA
AXI27226.1\|1607308_1609285_-	transketolase	NA	NA	NA	NA
AXI27227.1\|1609301_1609898_-	recombination protein RecR	NA	NA	NA	NA
AXI27228.1\|1609902_1610220_-	nucleoid-associated protein, YbaB/EbfC family	NA	NA	NA	NA
AXI27229.1\|1610325_1611990_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	1.1e-54	43.4
AXI27230.1\|1612195_1612915_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.9e-31	36.8
AXI27231.1\|1612924_1613566_-	amino acid ABC transporter permease	NA	NA	NA	NA
AXI27232.1\|1613584_1614406_-	arginine ABC transporter substrate-binding protein	NA	NA	NA	NA
AXI27233.1\|1614857_1615442_-	hypothetical protein	NA	NA	NA	NA
AXI27234.1\|1615454_1616858_-	ABC transporter ATP-binding protein	A0A2K9L0W2	Tupanvirus	1.5e-20	22.2
AXI27235.1\|1616844_1617534_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
AXI27236.1\|1617671_1620011_-	endonuclease MutS2	F2Y0V3	Organic_Lake_phycodnavirus	1.8e-13	21.8
AXI27237.1\|1620533_1621067_-	colicin V production CvpA	NA	NA	NA	NA
AXI27238.1\|1621159_1622806_-	hypothetical protein	NA	NA	NA	NA
AXI27239.1\|1622817_1623177_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
AXI27240.1\|1623391_1624324_-	ketopantoate reductase family protein	NA	NA	NA	NA
AXI27241.1\|1624605_1625652_-	PTS transporter subunit IIC	NA	NA	NA	NA
AXI27470.1\|1625805_1626714_-	YihY/virulence factor BrkB family protein	NA	NA	NA	NA
AXI27242.1\|1626715_1626973_-	hypothetical protein	NA	NA	NA	NA
AXI27243.1\|1627116_1627317_-	hypothetical protein	NA	NA	NA	NA
AXI27244.1\|1627783_1628065_-	type II secretion system protein	NA	NA	NA	NA
AXI27471.1\|1628054_1628498_-	type II secretion system protein	NA	NA	NA	NA
AXI27245.1\|1628472_1628751_-	competence protein ComG	NA	NA	NA	NA
AXI27246.1\|1628917_1629682_-	cell wall-binding protein	NA	NA	NA	NA
AXI27247.1\|1629788_1630634_-	hypothetical protein	A0A0E3Y6H2	Fusobacterium_phage	3.4e-23	38.2
AXI27248.1\|1630742_1630922_-	CopG family transcriptional regulator	NA	NA	NA	NA
AXI27249.1\|1631345_1631522_-	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
AXI27250.1\|1631630_1632476_-	hypothetical protein	NA	NA	NA	NA
AXI27251.1\|1632617_1633367_-	cell wall-binding protein	NA	NA	NA	NA
AXI27252.1\|1633540_1634272_-	cell wall hydrolase	F8HGP2	Streptococcus_phage	2.3e-76	61.5
AXI27253.1\|1634317_1634836_-	hypothetical protein	M1Q0Z8	Streptococcus_phage	6.2e-28	39.3
AXI27472.1\|1635132_1635351_-\|holin	holin	NA	NA	NA	NA
AXI27254.1\|1635390_1635780_-	hypothetical protein	A0A097BY69	Enterococcus_phage	2.3e-11	36.6
AXI27255.1\|1635785_1636034_-	hypothetical protein	NA	NA	NA	NA
AXI27256.1\|1636033_1636459_-	DUF1617 domain-containing protein	Q938J8	Temperate_phage	1.1e-22	44.7
AXI27257.1\|1636462_1640710_-	hypothetical protein	C5J973	Streptococcus_phage	1.7e-30	35.4
AXI27258.1\|1640706_1641420_-	hypothetical protein	NA	NA	NA	NA
AXI27259.1\|1641406_1645612_-\|tail	phage tail tape measure protein	H9A124	Staphylococcus_phage	4.2e-58	38.5
AXI27260.1\|1645804_1646107_-	hypothetical protein	NA	NA	NA	NA
AXI27261.1\|1646127_1646688_-	hypothetical protein	E3W8G1	Leuconostoc_phage	1.5e-24	37.9
AXI27262.1\|1646677_1647022_-	hypothetical protein	NA	NA	NA	NA
AXI27263.1\|1646981_1647383_-	hypothetical protein	NA	NA	NA	NA
AXI27264.1\|1647375_1647717_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
AXI27265.1\|1647726_1648008_-\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
AXI27266.1\|1648020_1649130_-\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	2.5e-18	24.8
AXI27267.1\|1649133_1649748_-\|head,protease	HK97 family phage prohead protease	F7V9A5	Lactobacillus_virus	5.1e-37	44.9
AXI27268.1\|1649964_1651293_-\|portal	phage portal protein	A0A075KK59	Lactobacillus_phage	7.6e-38	30.5
AXI27269.1\|1651342_1653022_-\|terminase	terminase	A0A1D3SNR2	Enterococcus_phage	2.6e-107	39.9

DBSCAN-SWA_5

1657134 : 1665931

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXI27276.1\|1657134_1657614_-	hypothetical protein	A0A218MNC6	uncultured_virus	3.8e-08	29.8
AXI27277.1\|1657629_1657977_-	hypothetical protein	A0A1C9LX52	Streptococcus_phage	7.3e-09	32.6
AXI27278.1\|1657989_1658229_-	hypothetical protein	NA	NA	NA	NA
AXI27473.1\|1658375_1658627_-	VRR-NUC domain-containing protein	A8ATF4	Listeria_phage	2.0e-16	51.9
AXI27279.1\|1658826_1661019_-	DNA primase	R4IBW2	Listeria_phage	2.4e-166	42.5
AXI27280.1\|1661029_1661452_-	hypothetical protein	O34042	Streptococcus_phage	2.1e-05	26.8
AXI27281.1\|1661471_1662767_-	helicase	Q8W5V9	Listeria_phage	8.6e-87	44.0
AXI27282.1\|1662754_1663306_-	hypothetical protein	NA	NA	NA	NA
AXI27283.1\|1663286_1663535_-	hypothetical protein	NA	NA	NA	NA
AXI27284.1\|1663501_1664203_-	hypothetical protein	A0A0A7RVW0	Clostridium_phage	9.9e-13	35.3
AXI27285.1\|1664203_1664533_-	hypothetical protein	NA	NA	NA	NA
AXI27286.1\|1664525_1664783_-	hypothetical protein	NA	NA	NA	NA
AXI27287.1\|1664941_1665115_-	CopG family transcriptional regulator	M1NRK8	Streptococcus_phage	2.4e-08	54.7
AXI27288.1\|1665421_1665931_-	hypothetical protein	A0A0E3XBR0	Staphylococcus_phage	7.7e-15	33.7

DBSCAN-SWA_6

1728115 : 1789907

Spiroplasma_virus(18.18%)

protease,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXI27475.1\|1728115_1729099_+\|transposase	IS481 family transposase	A8RHK4	Spiroplasma_virus	3.6e-08	31.8
AXI27353.1\|1730016_1731063_+	metal ABC transporter substrate-binding protein	NA	NA	NA	NA
AXI27354.1\|1731855_1732566_+	ABC transporter	A0A1V0SGN0	Hokovirus	2.6e-08	28.1
AXI27355.1\|1732558_1733353_+	metal ABC transporter permease	NA	NA	NA	NA
AXI27356.1\|1733466_1734402_+	50S ribosomal protein L11 methyltransferase	NA	NA	NA	NA
AXI27476.1\|1734927_1736277_+	hypothetical protein	NA	NA	NA	NA
AXI27357.1\|1736640_1737525_+	hypothetical protein	NA	NA	NA	NA
AXI27358.1\|1737676_1739230_-	ribonuclease Y	NA	NA	NA	NA
AXI27359.1\|1739629_1740055_+	50S ribosomal protein L11	NA	NA	NA	NA
AXI27360.1\|1740068_1740761_+	50S ribosomal protein L1	NA	NA	NA	NA
AXI27361.1\|1740820_1742197_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	7.1e-55	34.5
AXI27362.1\|1742391_1743024_-	hypothetical protein	NA	NA	NA	NA
AXI27363.1\|1743715_1744108_-	GntR family transcriptional regulator	NA	NA	NA	NA
AXI27364.1\|1744228_1744912_+	glycosyl transferase family 2	NA	NA	NA	NA
AXI27365.1\|1745179_1745521_+	4-carboxymuconolactone decarboxylase	NA	NA	NA	NA
AXI27366.1\|1745527_1746475_+	DUF3641 domain-containing protein	NA	NA	NA	NA
AXI27367.1\|1746655_1748032_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	7.1e-55	34.5
AXI27368.1\|1748217_1748448_-	acyl carrier protein	NA	NA	NA	NA
AXI27369.1\|1748450_1749437_-	phosphate acetyltransferase PlsX	NA	NA	NA	NA
AXI27370.1\|1749429_1750065_-	class A sortase	NA	NA	NA	NA
AXI27371.1\|1750076_1752089_-	DNA helicase RecG	NA	NA	NA	NA
AXI27372.1\|1752081_1752954_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
AXI27373.1\|1752965_1753634_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
AXI27374.1\|1753637_1755308_-	ribonuclease J	R9ZY20	Cellulophaga_phage	6.3e-05	28.1
AXI27375.1\|1755300_1755519_-	DUF1447 domain-containing protein	NA	NA	NA	NA
AXI27376.1\|1755518_1757093_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
AXI27377.1\|1757361_1758552_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
AXI27378.1\|1758589_1758955_-	iron-sulfur cluster assembly accessory protein	NA	NA	NA	NA
AXI27379.1\|1759095_1759350_+	NifU family protein	NA	NA	NA	NA
AXI27380.1\|1759450_1760512_-	peptidase M28	NA	NA	NA	NA
AXI27381.1\|1760513_1760789_-	hypothetical protein	NA	NA	NA	NA
AXI27382.1\|1760799_1761672_-	2-oxoacid ferredoxin oxidoreductase	NA	NA	NA	NA
AXI27383.1\|1761673_1763419_-	2-oxoacid:acceptor oxidoreductase subunit alpha	NA	NA	NA	NA
AXI27384.1\|1763686_1765492_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
AXI27385.1\|1765876_1766341_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
AXI27386.1\|1766357_1766534_-	hypothetical protein	NA	NA	NA	NA
AXI27387.1\|1766580_1768038_-	sodium/panthothenate symporter	NA	NA	NA	NA
AXI27388.1\|1768037_1768283_-	DUF997 domain-containing protein	NA	NA	NA	NA
AXI27389.1\|1768275_1768878_-	PAP2 family protein	NA	NA	NA	NA
AXI27390.1\|1768879_1769962_-	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase	NA	NA	NA	NA
AXI27391.1\|1769964_1770456_-	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	1.0e-27	44.4
AXI27392.1\|1770458_1771010_-	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	NA	NA	NA	NA
AXI27393.1\|1771070_1771340_-	DUF2129 domain-containing protein	NA	NA	NA	NA
AXI27394.1\|1771351_1773439_-	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
AXI27395.1\|1773703_1776205_-	collagen-binding protein	NA	NA	NA	NA
AXI27396.1\|1776798_1778433_-	sodium-dependent phosphate transporter	NA	NA	NA	NA
AXI27477.1\|1778690_1778972_-	50S ribosomal protein L27	NA	NA	NA	NA
AXI27397.1\|1778977_1779307_-\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
AXI27398.1\|1779309_1779618_-	50S ribosomal protein L21	NA	NA	NA	NA
AXI27399.1\|1779943_1780831_-	stage III sporulation protein J	NA	NA	NA	NA
AXI27400.1\|1782986_1784267_-	uracil permease	Q9KX94	Enterobacteria_phage	3.6e-61	37.7
AXI27401.1\|1784668_1785007_+	hypothetical protein	NA	NA	NA	NA
AXI27402.1\|1785197_1785662_-\|transposase	IS200/IS605 family transposase	W0UUZ0	Sulfolobus_monocaudavirus	1.4e-18	40.8
AXI27403.1\|1785899_1786484_-	peptidylprolyl isomerase	A0A1V0S9I2	Catovirus	1.0e-23	41.8
AXI27404.1\|1786557_1788501_-\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	3.4e-111	35.9
AXI27405.1\|1788923_1789907_+\|transposase	IS481 family transposase	A8RHK4	Spiroplasma_virus	3.6e-08	31.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage