CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP029072	Mycobacterium abscessus strain G220 chromosome, complete genome	1 crisprs	DEDDh,cas3,csa3,DinG,cas4,WYL	0	1	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP029072_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP029072_2

4800154-4800269

Orphan

Consensus_repeat	Method
TCGTTGATGGCACTGGTGTGGGCACCACCACCGACAGCCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP029072_2

>merge|CP029072|2|4800154-4800269|CRISPRCasFinder
TCGTTGATGGCACTGGTGTGGGCACCACCACCGACAGCCGTGCTGCCGCCAACAGAACCCGAACCACCCAGGGCATCGTTGATGGCACTGGTGTGGGCACCACCGCCGACAGCCGT

>CP029072|2|2|4800154-4800269|CRISPRCasFinder
TCGTTGATGGCACTGGTGTGGGCACCACCACCGACAGCCGT	GCTGCCGCCAACAGAACCCGAACCACCCAGGGCA
TCGTTGATGGCACTGGTGTGGGCACCACCGCCGACAGCCGT

Protein	Signature genes	Signature genes Name	Protein_function
CP029072.1\|AWG71962.1\|4792730_4793666_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274648
CP029072.1\|AWG71461.1\|4791242_4792094_-\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|223856
CP029072.1\|AWG71464.1\|4794184_4794691_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226406
CP029072.1\|AWG71463.1\|4793692_4794160_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
CP029072.1\|AWG71466.1\|4795821_4796478_-\|hypothetical-protein	unknown	unknown	unknown
CP029072.1\|AWG71963.1\|4795148_4795802_-\|hypothetical-protein	unknown	unknown	unknown
CP029072.1\|AWG71468.1\|4797972_4799856_-\|Isoniazid-inducible-protein-iniA	unknown	unknown	gnl\|CDD\|223771
CP029072.1\|AWG71465.1\|4794684_4795071_-\|hypothetical-protein	unknown	unknown	unknown
CP029072.1\|AWG71467.1\|4796482_4797976_-\|Isoniazid-inducible-protein-iniC	unknown	unknown	gnl\|CDD\|206739
CP029072.1\|AWG71462.1\|4792109_4792589_-\|thiol:disulfide-interchange-protein	unknown	unknown	gnl\|CDD\|239309

Protein	Function_ID	Function_description	E-value
CP029072.1\|AWG71962.1\|4792730_4793666_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	5.23876e-110
CP029072.1\|AWG71461.1\|4791242_4792094_-\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|223856	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones].	4.73545e-17
CP029072.1\|AWG71464.1\|4794184_4794691_+\|hypothetical-protein	gnl\|CDD\|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	4.28315e-06
CP029072.1\|AWG71463.1\|4793692_4794160_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	0.00103577
CP029072.1\|AWG71462.1\|4792109_4792589_-\|thiol:disulfide-interchange-protein	gnl\|CDD\|239309	cd03011, TlpA_like_ScsD_MtbDsbE, TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif. The Salmonella typhimurium ScsD is a thioredoxin-like protein which confers copper tolerance to copper-sensitive mutants of E. coli. MtbDsbE has been characterized as an oxidase in vitro, catalyzing the disulfide bond formation of substrates like hirudin. The reduced form of MtbDsbE is more stable than its oxidized form, consistent with an oxidase function. This is in contrast to the function of DsbE from gram-negative bacteria which is a specific reductase of apocytochrome c.	1.07707e-32
CP029072.1\|AWG71468.1\|4797972_4799856_-\|Isoniazid-inducible-protein-iniA	gnl\|CDD\|223771	COG0699, COG0699, Predicted GTPases (dynamin-related) [General function prediction only].	1.86063e-21
CP029072.1\|AWG71467.1\|4796482_4797976_-\|Isoniazid-inducible-protein-iniC	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	3.21242e-10

>CP029072.1|AWG71468.1|4797972_4799856_-|Isoniazid-inducible-protein-iniA
MSDTAQDGQQQLVLINELLGHVRKIAGENDRGDLIDRLDRADQLLVDRPLRVVVAGQLKQGKSQLVNSLLNMPVARVGDDETTSVTTVIGYGEQPSAALVVAPAEQYDGGGLAGEPEIIPIPVADIGKDLKRAPQAQGREVLRVEVKVASPILKSGLCLVDTPGVGGFGQPHLSSTLGLLPDADVMLMVSDLSSEFTEPELVFIQQALDLCPVAAIVNTKTDLYPHWRAVVAANSAHLQRAKIAVPAIAVSSALRSHALQLNDKELNTESNFPALVTFLSNAIADQQASTRQQAIAEIGSASEHLTLTLEAELSALQDPQSRDELTSDLERRKREAEEALAHTALWQQVLGDGITDVSTDVEHDLQSRFRRILQRTEEVIDRTDPTKNWAEIGAKLEQAVANSVGNNFVWAHQRAMHLAAQVAETFAIDGLESVKMPRLRASEMGADLSDLKSLSKLEAKQIKLGHKAITGLRGSYGGVIMFGMLTSVAGLGMFNLISLGAGAMLGKKTYNEDMENRMLRIRGEAKTNVRRFLDDVSFVVLKESRDRLRLVQRQLRDHFREIANQTTRSLNESLQAAIASARLEAEERDARTNEVERQLHILRQVNSHVERLQPTDEQAARRATRDV
>CP029072.1|AWG71467.1|4796482_4797976_-|Isoniazid-inducible-protein-iniC
MSSVAQARVIIGDAMLAYQNDSRYLRVAEPHDELRRIAARLDEPIRVAIAGTLNAGKSTLVNALVGEDIAPTDATEATRIVAWFRHGAAPRVTANLFSGVRQDIPIRREGGLSFELDRLDPALVADLDVNWPAPELNEITLIDTPGTSSLSTDVSERSLALLVPEDGVPRVDAVIFLLRSLNAADIGLLTQIGKLVGGERGGAVGVVGVVSRADEIGVGRLDAMLSAREVAARFAGEMERTGICQAVVPVAGLLALTARTLRQAEFVALQRLAELDPQVLAKALLSVDRFVREDDSLPVDAQTRAALLHRFGMFGIRISVAVMRVGVTDATGLAEELLERSGLVELHNIIANQFGQRAGILKSHTALLSARRVLTTYPVHGGRRVIDNIDPLLADTHAFDELRLLAELSSHSTTLTEHEIMLIRRLLGSFGTDAAARLGLDETRSDPRRAALDAVGRWRARAEHPLNDPFTSRLCLAAVRSAEGILTQLSAHDRPAY
>CP029072.1|AWG71466.1|4795821_4796478_-|hypothetical-protein
MMMRLFVATLALVAGFSTATAAAEPTPSPAGPASKPVPAGVWISPAEIPMNSDYHWSAVSPTATGRAAFLSMRLCGSPSADVLPPASAIATQAASGVAASVVQAAGQWPEGNTEGASAFQSGIRSQLNYCPGVGDVISVDLRPAPSWYGFAATLLIGKERDNPTSEVHIYNVVPPESGTVSELAVTVPRTGREPSPWKPVDDATVLRALAQPLCKGSC
>CP029072.1|AWG71963.1|4795148_4795802_-|hypothetical-protein
MRGWLRAISALVVISGLGAAVPAAAEPKSLPDSVWINPRDIPLDRASHWAPLSRSAAPVDRPAFWSANLCFSLGESLPQSPESASATVSSDESGWTAVEVIAHWPGEAVVTDQYASTVYRSLRGRLDHCFNAIGAQVSVTDLTNGHAATVTLPAQGGKQPQYHLYVVQPPGTGTVAELTVTNAITGAAGASWVEADDHQVLRDLAAPICRTAKSTAC
>CP029072.1|AWG71465.1|4794684_4795071_-|hypothetical-protein
MHGRGVLSGVCGIATIIAMAVLLTPVSIQVGTGETAQTVTCGMPVGPRLSRTAELDKISSAQNQSTNYHDQCAAKLDTRRMWAIPIGVLSFVIALCAAGHLWKENTPSSSPAQTRHGLSGPPGMRMAH
>CP029072.1|AWG71464.1|4794184_4794691_+|hypothetical-protein
MSYPEPPEDPTMFNQQYHDQGPDQPNPWYKQPAVLIALAGAGVAVVAVIAALIITRSDDKPAPAGNTSSVSSTTSSTPTDSGGGGHEGHGGHGGGNTTVTETQTVPESPTSQDTTTTEPTTTTTTTTEPTTTTTQPTTTTTQPTTSTRPSVVVPIPGGGNIQVPVGGQ
>CP029072.1|AWG71463.1|4793692_4794160_+|hypothetical-protein
MSQTPKPPEDESYFSEMIKESEKPTPWYRTGPAIVGTIAAIIAIVAVLMTIVLSTDKRVVRDNTPLTSTPSVSSTAPTAQPTSPSESSTAVPTATEAPPEPVAPAQTSEPTYYETPTSTIYRYPIPAIPSPPPIPPIPAIPQIPQIPQIPQIPGL
>CP029072.1|AWG71962.1|4792730_4793666_+|LLM-class-F420-dependent-oxidoreductase
MDFRVFVEPQQGATYSDQLRVAQAAEELGFSAFFRSDHYLAMGGADGLPGPTDAWVTLGAIARETTAIRLGTLVTSATFRHPGPLAVTVAQVDEMSSGRVDFGLGAGWFSEEHEAYAIPFPSLGERFDRLEEQLEILTGLWTTPTGDTYSYAGKHYTVTDSPALPKPVQEPHPPIVIGGLGVKRTPALAARFAAEFNLPFQPVDVIADRYARVAQAVEAAGRPADSMVYSAAFAVCIGDTDTEIARRAANARREVEEITENSPLAGTPDAVAEKLSIYVDAGVQRVYVQLLDIRDLDHLEFFASTVIPQFS
>CP029072.1|AWG71462.1|4792109_4792589_-|thiol:disulfide-interchange-protein
MAVLALTLSVGLSGCSGTEKGETSSAPSSRLLNFTAQTIDGADFAGSSLAGKKAVLWFWAPWCPTCKKEAPDLQKATTAHPDVTFVGVAAQDQVPAMRDFVTKYGLTFIQLADTDAKVWALYDVTHQPAFAFLGSEGKAEVVKSPLSGPELDKKIRQLH
>CP029072.1|AWG71461.1|4791242_4792094_-|cytochrome-c-biogenesis-protein-CcdA
MIDTAALTFALGAGLVAALNPCGFAFLPGYLGLVIAGSDGTASRMTAIARAATATVAMAGGFLTVFGVFGLVISPVVASAGRYMPFATVVIGVVLVALSIWLLCGRELTLVLPRVSGGAPTASLLSMFGYGLTYAVASLSCTVGPFLAVISTTFKQGSIVSGVLAFIAYGVGMTVTVGVAALAVALLGNSVQATMRKVLPYVGRIAGVIVLLTGLYVAYYGYYEIRLNFGDGSADDPVINAAGAVQTWLVGAVDATGVWPPIGGIALIVAVAAVSSYAVRKGR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP029072_1	1.1\|1490503\|26\|CP029072\|CRISPRCasFinder	1490503-1490528	26	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	418376-418401	5	0.808
CP029072_1	1.1\|1490503\|26\|CP029072\|CRISPRCasFinder	1490503-1490528	26	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	678153-678178	5	0.808
CP029072_1	1.1\|1490503\|26\|CP029072\|CRISPRCasFinder	1490503-1490528	26	NZ_CP029333	Mycobacterium avium subsp. hominissuis strain MAC109 plasmid pMAC109a, complete sequence	54049-54074	6	0.769
CP029072_1	1.1\|1490503\|26\|CP029072\|CRISPRCasFinder	1490503-1490528	26	NC_022654	Mycobacterium kansasii ATCC 12478 plasmid pMK12478, complete sequence	143457-143482	6	0.769

1. spacer 1.1|1490503|26|CP029072|CRISPRCasFinder matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 5, identity: 0.808

aaccccggccagggtggttggggcca	CRISPR spacer
gaccccggccagggtggtcgcggcgg	Protospacer
.*****************.* *** .

2. spacer 1.1|1490503|26|CP029072|CRISPRCasFinder matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 5, identity: 0.808

aaccccggccagggtggttggggcca	CRISPR spacer
gaccccggccagggtggtcgcggcgg	Protospacer
.*****************.* *** .

3. spacer 1.1|1490503|26|CP029072|CRISPRCasFinder matches to NZ_CP029333 (Mycobacterium avium subsp. hominissuis strain MAC109 plasmid pMAC109a, complete sequence) position: , mismatch: 6, identity: 0.769

aaccccggccagggtggttggggcca	CRISPR spacer
ttgcccggcgagggtggttggggcac	Protospacer
   ****** **************

4. spacer 1.1|1490503|26|CP029072|CRISPRCasFinder matches to NC_022654 (Mycobacterium kansasii ATCC 12478 plasmid pMK12478, complete sequence) position: , mismatch: 6, identity: 0.769

aaccccggccagggtggttggggcca	CRISPR spacer
ttgcccggcgagggtggttggggcac	Protospacer
   ****** **************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

498422 : 506794

Mycobacterium_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AWG71509.1\|498422_499892_+	serine hydrolase	A0A1J0GRK9	Mycobacterium_phage	9.4e-13	28.5
AWG67713.1\|500019_500832_+	DUF1906 domain-containing protein	A0A2D1GEF2	Gordonia_phage	3.1e-50	49.1
AWG67714.1\|500880_502077_-	LysM peptidoglycan-binding domain-containing protein	A0A1W6JL93	Lactococcus_phage	2.6e-05	47.3
AWG67715.1\|502506_503355_+	N-acetylmuramoyl-L-alanine amidase	A0A2D1GEV9	Mycobacterium_phage	2.9e-67	56.1
AWG67716.1\|503521_503824_-	tetratricopeptide repeat protein	NA	NA	NA	NA
AWG67717.1\|504115_504565_+	hypothetical protein	NA	NA	NA	NA
AWG67718.1\|504585_506037_+	sensor histidine kinase	Q8QKV4	Ectocarpus_siliculosus_virus	2.9e-06	33.6
AWG67719.1\|506116_506794_-	DNA-binding response regulator	W8CYM9	Bacillus_phage	4.4e-26	31.4

DBSCAN-SWA_2

994285 : 1039876

Staphylococcus_phage(33.33%)

holin,capsid,integrase,protease

attL 992653:992669|attR 1026962:1026978

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
992653:992669	attL	NA	NA	NA	NA
AWG68145.1\|994285_995551_+\|protease	serine protease	NA	NA	NA	NA
AWG68146.1\|995524_996487_-	alpha/beta hydrolase	NA	NA	NA	NA
AWG68147.1\|996519_997041_-\|holin	phage holin family protein	NA	NA	NA	NA
AWG68148.1\|997290_997986_+	peptidase	NA	NA	NA	NA
AWG68149.1\|998075_1000052_-	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	7.7e-79	37.3
AWG68150.1\|1000235_1001855_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AWG68151.1\|1001851_1002823_+	ABC transporter permease	NA	NA	NA	NA
AWG68152.1\|1002815_1003730_+	ABC transporter permease	NA	NA	NA	NA
AWG68153.1\|1003730_1005380_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-21	32.8
AWG68154.1\|1005404_1006148_+	oxidoreductase	NA	NA	NA	NA
AWG68155.1\|1006563_1007445_-	HAD-IB family hydrolase	NA	NA	NA	NA
AWG68156.1\|1007623_1007872_+	hypothetical protein	NA	NA	NA	NA
AWG68157.1\|1007828_1008902_+	helicase	NA	NA	NA	NA
AWG68158.1\|1009535_1010924_+\|integrase	integrase	NA	NA	NA	NA
AWG68159.1\|1010889_1012812_+\|integrase	site-specific integrase	NA	NA	NA	NA
AWG68160.1\|1012808_1015295_+\|integrase	integrase	NA	NA	NA	NA
AWG68161.1\|1015281_1015680_+	hypothetical protein	NA	NA	NA	NA
AWG71556.1\|1015828_1019227_+	type III restriction endonuclease subunit R	NA	NA	NA	NA
AWG68162.1\|1019263_1019521_-	XRE family transcriptional regulator	NA	NA	NA	NA
AWG68163.1\|1019582_1020272_+	hypothetical protein	NA	NA	NA	NA
AWG68164.1\|1020719_1022402_+	hypothetical protein	NA	NA	NA	NA
AWG68165.1\|1022772_1024578_+	AAA family ATPase	NA	NA	NA	NA
AWG68166.1\|1025138_1025792_+	amidohydrolase	NA	NA	NA	NA
AWG68167.1\|1026365_1026716_+	hypothetical protein	G8I4H6	Mycobacterium_phage	7.1e-12	40.2
AWG68168.1\|1026869_1028474_+	RNA polymerase subunit sigma	NA	NA	NA	NA
1026962:1026978	attR	NA	NA	NA	NA
AWG68169.1\|1028870_1030058_+	hypothetical protein	NA	NA	NA	NA
AWG71557.1\|1030110_1030458_+	DUF4279 domain-containing protein	NA	NA	NA	NA
AWG68170.1\|1030706_1031075_+	hypothetical protein	NA	NA	NA	NA
AWG68171.1\|1031504_1031930_+	hypothetical protein	NA	NA	NA	NA
AWG68172.1\|1032820_1033597_+	hypothetical protein	NA	NA	NA	NA
AWG68173.1\|1033593_1034178_+	pilus assembly protein TadC	NA	NA	NA	NA
AWG68174.1\|1034516_1034753_+	hypothetical protein	NA	NA	NA	NA
AWG71558.1\|1035010_1035262_+	hypothetical protein	NA	NA	NA	NA
AWG71559.1\|1035870_1036173_+	hypothetical protein	NA	NA	NA	NA
AWG71560.1\|1036628_1037033_+	hypothetical protein	NA	NA	NA	NA
AWG68175.1\|1037229_1037994_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AWG68176.1\|1038062_1038302_+	hypothetical protein	NA	NA	NA	NA
AWG68177.1\|1038490_1038931_+	hypothetical protein	NA	NA	NA	NA
AWG68178.1\|1039045_1039876_+\|capsid	phage major capsid protein	NA	NA	NA	NA

DBSCAN-SWA_3

1684387 : 1691128

Mycobacterium_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AWG68738.1\|1684387_1685410_-	acyltransferase	A9YX16	Burkholderia_phage	2.5e-25	29.1
AWG68739.1\|1685674_1686277_+	alpha/beta hydrolase	NA	NA	NA	NA
AWG68740.1\|1686218_1686965_-	XRE family transcriptional regulator	NA	NA	NA	NA
AWG71623.1\|1687277_1688009_+	hypothetical protein	A0A068F4L5	Mycobacterium_phage	3.5e-61	54.0
AWG71624.1\|1687995_1688433_-	hypothetical protein	A0A2D1GA16	Mycobacterium_phage	2.2e-34	57.1
AWG71625.1\|1688646_1688964_+	XRE family transcriptional regulator	A0A2D1GA98	Mycobacterium_phage	2.4e-22	58.9
AWG68741.1\|1688960_1689293_+	hypothetical protein	NA	NA	NA	NA
AWG68742.1\|1689289_1690150_+	hypothetical protein	A0A0K1LSM7	Mycobacterium_phage	1.3e-70	55.4
AWG68743.1\|1690142_1690940_+	hypothetical protein	A0A0K1LRE4	Mycobacterium_phage	2.2e-141	89.1
AWG68744.1\|1690936_1691128_+	hypothetical protein	A0A2D1GAF3	Mycobacterium_phage	7.8e-13	66.7

DBSCAN-SWA_4

1700711 : 1741239

Mycobacterium_phage(75.76%)

protease,portal,capsid,tail,head,transposase,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AWG71627.1\|1700711_1701266_+	hypothetical protein	A0A0K1LTX7	Mycobacterium_phage	1.2e-08	37.9
AWG68763.1\|1701258_1701474_+	hypothetical protein	NA	NA	NA	NA
AWG68764.1\|1701875_1702124_+	WhiB family transcriptional regulator	A0A097EWF7	Mycobacterium_phage	3.2e-14	50.0
AWG68765.1\|1702123_1702438_+	WhiB family transcriptional regulator	A0A1B0XUI6	Freshwater_phage	2.4e-14	51.4
AWG68766.1\|1702476_1702674_+	hypothetical protein	NA	NA	NA	NA
AWG71628.1\|1702804_1703110_+	hypothetical protein	NA	NA	NA	NA
AWG68767.1\|1703352_1703547_+	hypothetical protein	NA	NA	NA	NA
AWG68768.1\|1703794_1704085_+	hypothetical protein	NA	NA	NA	NA
AWG68769.1\|1704081_1704276_+	hypothetical protein	NA	NA	NA	NA
AWG68770.1\|1704251_1704935_+	hypothetical protein	A0A2L0HK00	Mycobacterium_phage	3.2e-48	45.8
AWG68771.1\|1704960_1705161_+	hypothetical protein	NA	NA	NA	NA
AWG68772.1\|1705232_1705511_+\|transposase	transposase	A0A088FQJ6	Mycobacterium_phage	6.5e-16	50.0
AWG68773.1\|1705507_1705960_+	hypothetical protein	A0A2P1JZV1	Mycobacterium_phage	4.4e-06	47.8
AWG68774.1\|1706247_1706466_+	hypothetical protein	NA	NA	NA	NA
AWG68775.1\|1706458_1706758_+	hypothetical protein	NA	NA	NA	NA
AWG68776.1\|1706754_1707084_+	hypothetical protein	A0A088FQ47	Mycobacterium_phage	1.1e-14	44.4
AWG68777.1\|1707121_1707466_+	hypothetical protein	NA	NA	NA	NA
AWG68778.1\|1707504_1707813_+	hypothetical protein	NA	NA	NA	NA
AWG68779.1\|1707805_1708081_+	hypothetical protein	NA	NA	NA	NA
AWG68780.1\|1708737_1708926_+	hypothetical protein	NA	NA	NA	NA
AWG68781.1\|1708932_1709337_+	hypothetical protein	M4W6B5	Mycobacterium_phage	2.2e-28	57.9
AWG68782.1\|1709329_1709629_+	hypothetical protein	NA	NA	NA	NA
AWG68783.1\|1709616_1709865_+	MFS transporter	A0A2H4PFU6	Mycobacterium_phage	1.1e-11	43.4
AWG68784.1\|1709864_1710140_+	hypothetical protein	A0A2P1JRH4	Mycobacterium_phage	1.7e-29	66.7
AWG68785.1\|1710252_1710609_+	hypothetical protein	G9FH26	Rhodococcus_phage	1.8e-23	58.3
AWG68786.1\|1710643_1712101_+\|terminase	terminase	G9FH27	Rhodococcus_phage	3.5e-129	53.7
AWG68787.1\|1712255_1713716_+\|portal	phage portal protein	A0A1B3AZW5	Gordonia_phage	6.4e-171	64.3
AWG68788.1\|1713712_1714639_+\|head,protease	HK97 family phage prohead protease	A0A1B3AYS9	Gordonia_phage	1.2e-53	46.5
AWG68789.1\|1714641_1716072_+\|capsid	phage major capsid protein	A0A1B3B249	Gordonia_phage	3.5e-113	49.0
AWG68790.1\|1716079_1716586_+	aspartyl beta-hydroxylase	NA	NA	NA	NA
AWG68791.1\|1716582_1716813_+	hypothetical protein	NA	NA	NA	NA
AWG68792.1\|1716809_1717223_+	hypothetical protein	NA	NA	NA	NA
AWG68793.1\|1717223_1717781_+	hypothetical protein	A0A0A7RVK3	Mycobacterium_phage	6.8e-65	65.9
AWG68794.1\|1717777_1718116_+	hypothetical protein	A0A0A7RVI5	Mycobacterium_phage	9.9e-27	52.0
AWG68795.1\|1718115_1718481_+	HK97 gp10 family phage protein	A0A2P1JR51	Mycobacterium_phage	3.0e-21	46.2
AWG68796.1\|1718477_1718891_+	hypothetical protein	Q854Y7	Mycobacterium_virus	1.2e-34	53.3
AWG68797.1\|1718972_1720067_+	hypothetical protein	A0A2P1JR54	Mycobacterium_phage	2.7e-73	55.0
AWG68798.1\|1720147_1720651_+	hypothetical protein	A0A2D1GAT8	Mycobacterium_phage	1.3e-19	39.0
AWG71629.1\|1720802_1720994_+	hypothetical protein	NA	NA	NA	NA
AWG68799.1\|1721006_1725056_+\|tail	phage tail tape measure protein	A0A0K1LLI9	Mycobacterium_phage	1.0e-130	59.4
AWG68800.1\|1725055_1726780_+	hypothetical protein	A0A142K810	Mycobacterium_phage	1.4e-230	65.0
AWG68801.1\|1726823_1728527_+	hypothetical protein	S5YA01	Mycobacterium_phage	8.2e-279	80.8
AWG68802.1\|1728581_1729418_+	hypothetical protein	H6WSC0	Mycobacterium_phage	4.3e-95	61.9
AWG68803.1\|1729414_1733518_+	hypothetical protein	A0A0K1LLJ4	Mycobacterium_phage	8.0e-179	44.6
AWG68804.1\|1733529_1733928_+	hypothetical protein	A0A0U1UNR7	Pseudomonas_phage	7.3e-29	49.6
AWG68805.1\|1733930_1735151_+	hypothetical protein	G3MDN1	Mycobacterium_phage	1.6e-26	41.9
AWG68806.1\|1735166_1735604_+	hypothetical protein	A0A2P1JR64	Mycobacterium_phage	4.2e-54	73.9
AWG68807.1\|1735864_1737262_+	chitinase	A0A142F1U1	Mycobacterium_phage	2.4e-114	49.3
AWG68808.1\|1737264_1737699_+	hypothetical protein	NA	NA	NA	NA
AWG71630.1\|1737749_1738664_+	hypothetical protein	A0A2P1CCW0	Mycobacterium_phage	6.1e-55	44.4
AWG71631.1\|1738927_1740124_+	hypothetical protein	S5W0N6	Mycobacterium_phage	2.1e-119	56.2
AWG68809.1\|1740149_1740374_+	hypothetical protein	NA	NA	NA	NA
AWG68810.1\|1740356_1740584_-	hypothetical protein	NA	NA	NA	NA
AWG68811.1\|1740996_1741239_+	hypothetical protein	A0A222ZLP9	Mycobacterium_phage	7.4e-08	40.3

DBSCAN-SWA_5

3288882 : 3297443

Streptococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AWG70119.1\|3288882_3289554_-	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	4.9e-17	31.1
AWG70120.1\|3289667_3290591_+	peptidylprolyl isomerase	A0A1V0SCU1	Indivirus	1.1e-08	31.6
AWG70121.1\|3290592_3291462_+	class A beta-lactamase	A0A1B0VBP7	Salmonella_phage	1.3e-54	46.0
AWG70122.1\|3291565_3293932_-	RelA/SpoT family protein	A0A291L9W9	Bordetella_phage	1.8e-13	38.4
AWG70123.1\|3293962_3294496_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	1.4e-14	36.4
AWG70124.1\|3294492_3296169_-	hypothetical protein	NA	NA	NA	NA
AWG70125.1\|3296168_3297443_-	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.5e-22	28.6

DBSCAN-SWA_6

4598891 : 4608390

Burkholderia_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AWG71939.1\|4598891_4600016_-	acyltransferase	A9YX16	Burkholderia_phage	7.1e-21	29.0
AWG71299.1\|4600012_4601281_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	3.3e-06	40.3
AWG71300.1\|4601330_4602137_-	macrocin O-methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	4.9e-56	52.6
AWG71940.1\|4602347_4603040_-	class I SAM-dependent methyltransferase	Q98VI8	Paramecium_bursaria_Chlorella_virus	3.7e-12	30.2
AWG71301.1\|4603272_4604406_-	acyltransferase	A9YX16	Burkholderia_phage	1.2e-15	26.4
AWG71302.1\|4604573_4605635_-	NAD-dependent dehydratase	A0A0E3IB24	Synechococcus_phage	1.6e-17	25.8
AWG71303.1\|4605798_4607121_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	1.7e-05	39.2
AWG71304.1\|4607200_4607380_-	hypothetical protein	NA	NA	NA	NA
AWG71305.1\|4607523_4608390_+	glucose-1-phosphate thymidylyltransferase	H9NC64	Sphingomonas_phage	2.8e-89	57.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage