CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP028165	Staphylococcus aureus strain CFSAN064037 chromosome, complete genome	1 crisprs	cas3,csa3,DEDDh,WYL,DinG	0	0	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP028165_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028165_1

928717-928805

Orphan

Consensus_repeat	Method
TTACAACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of CP028165_1

>merge|CP028165|1|928717-928805|CRISPRCasFinder
TTACAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTATTTTACAACTTTAGTTGTTAGGGGCTCTTATGCA

>CP028165|1|1|928717-928805|CRISPRCasFinder
TTACAACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTATT
TTACAACTTTAGTTGTTAGGGGCTCTTATGCA

Protein	Signature genes	Signature genes Name	Protein_function
CP028165.1\|AVS03171.1\|935401_937207_-\|glutamine--fructose-6-phosphate-aminotransferase	unknown	unknown	gnl\|CDD\|234729
CP028165.1\|AVS03173.1\|939460_941593_+\|PTS-lactose-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|226234
CP028165.1\|AVS03174.1\|941604_942039_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
CP028165.1\|AVS03163.1\|926043_926364_+\|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
CP028165.1\|AVS03175.1\|942038_943145_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
CP028165.1\|AVS03159.1\|921545_922919_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
CP028165.1\|AVS03166.1\|928902_928995_+\|erm-Leader-peptide	unknown	unknown	unknown
CP028165.1\|AVS03156.1\|919199_919910_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
CP028165.1\|AVS03162.1\|925226_925892_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
CP028165.1\|AVS03158.1\|920674_921088_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
CP028165.1\|AVS03167.1\|929142_930000_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
CP028165.1\|AVS03157.1\|920030_920474_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
CP028165.1\|AVS03170.1\|933246_935250_-\|ATP-dependent-endonuclease	unknown	unknown	gnl\|CDD\|226121
CP028165.1\|AVS03172.1\|937887_939426_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
CP028165.1\|AVS03161.1\|923853_924792_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
CP028165.1\|AVS03164.1\|926365_927346_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
CP028165.1\|AVS03165.1\|927611_928703_+\|transcriptional-regulator	unknown	unknown	unknown
CP028165.1\|AVS03168.1\|930067_930850_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
CP028165.1\|AVS03160.1\|923592_923823_-\|hypothetical-protein	unknown	unknown	unknown
CP028165.1\|AVS03169.1\|931328_933254_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288

Protein	Function_ID	Function_description	E-value
CP028165.1\|AVS03171.1\|935401_937207_-\|glutamine--fructose-6-phosphate-aminotransferase	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
CP028165.1\|AVS03173.1\|939460_941593_+\|PTS-lactose-transporter-subunit-IIB	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	7.58425e-67
CP028165.1\|AVS03174.1\|941604_942039_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
CP028165.1\|AVS03163.1\|926043_926364_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
CP028165.1\|AVS03175.1\|942038_943145_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
CP028165.1\|AVS03159.1\|921545_922919_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
CP028165.1\|AVS03156.1\|919199_919910_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
CP028165.1\|AVS03162.1\|925226_925892_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.54377e-47
CP028165.1\|AVS03158.1\|920674_921088_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	4.41929e-45
CP028165.1\|AVS03167.1\|929142_930000_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	4.35599e-58
CP028165.1\|AVS03157.1\|920030_920474_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
CP028165.1\|AVS03170.1\|933246_935250_-\|ATP-dependent-endonuclease	gnl\|CDD\|226121	COG3593, COG3593, Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair].	1.17368e-29
CP028165.1\|AVS03172.1\|937887_939426_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
CP028165.1\|AVS03161.1\|923853_924792_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	1.22779e-128
CP028165.1\|AVS03164.1\|926365_927346_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.73825e-109
CP028165.1\|AVS03168.1\|930067_930850_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	5.40486e-98
CP028165.1\|AVS03169.1\|931328_933254_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.58898e-50

>CP028165.1|AVS03165.1|927611_928703_+|transcriptional-regulator
MFTYFKSALKNAKPQLLITLIYAFIAFAVIAGVYLLANFQLAKYVQTIAIYSQFGQKPPGDAYLKAIAILLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGIYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDNKVVTEPKNTKVETDKVTTSVETKTEKAQDSLIDNTTKTMTSDKPEDNQPK
>CP028165.1|AVS03164.1|926365_927346_+|cation-transporter
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHQAHHHAHVH
>CP028165.1|AVS03163.1|926043_926364_+|ArsR-family-transcriptional-regulator
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>CP028165.1|AVS03162.1|925226_925892_-|SDR-family-NAD(P)-dependent-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQVISGEQDIKDALTQFENETD
>CP028165.1|AVS03161.1|923853_924792_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGRLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>CP028165.1|AVS03160.1|923592_923823_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>CP028165.1|AVS03159.1|921545_922919_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>CP028165.1|AVS03158.1|920674_921088_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIQLITALPNRTKLLSVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>CP028165.1|AVS03157.1|920030_920474_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>CP028165.1|AVS03156.1|919199_919910_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>CP028165.1|AVS03166.1|928902_928995_+|erm-Leader-peptide
MTYGSIIAIVCALFVIFFIPYMEKNNKKKK
>CP028165.1|AVS03167.1|929142_930000_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLIEKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKHQQIYYEVFPFEGNRVSLKEDETWMRDMICSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLAKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTTYTNEEDGAAKYLAKHFLAD
>CP028165.1|AVS03168.1|930067_930850_-|ABC-transporter-ATP-binding-protein
MLITLNHVGRLKQGKPILQDVSWQIDEGDKWVLYGLNGAGKTTLLNILNTYEPATSGTVNLFGKMPGKLGYSAENVRQQIGFVSHSLLEKFQEGETVIDVVMSGAFKSIGLYKNVDDDIISEAHQLLKLVEMSDKAQQFIGYLSTGEKQRVMIARALMGQPRILILDEPAAGLDFIARESLLNILDSLSDTYPTLAMIYVTHFIEEITANFSKILLLKDGQSIQQGAVEDILTSENMSYFFQKNVAVQKWNNRFSMAMLE
>CP028165.1|AVS03169.1|931328_933254_-|ATP-dependent-helicase
MNNRILEDEWKPSDDVTLEDSALHAIRASSHVAIAAGPGAGKTELLAHKAGYLIETGMCPYPKKILAISFKTDAARNLQERVELRYGKGVEKRFESKTFDAFAKGILDQFIHALPKEYQPQKNYEIILNEKSLNDIINAYITEPYSYYSNWQYEYHINSVLRTMKETKLPIVSFEDDLYSWINERLWMALLNGKGNLKSSLTFSMISILVEYLLKENPLLVKALQATYSHVFLDEFQDTTHIQYNLLKTIFLKSNTVITAVGDNKQRIMGWAGALQNAFGIFKTDFNATQYTLLNNFRSAPNLVYIQNIFSKTLNDASIEVLPAGEWNKNEGVCEIWNFKNHNIEAILLASYISKWMKVENLKPRDFCIIVKQHEHIYAAEIMKELSKINIKSRIEKDYQDLLSEELVLLIIRFLKLSYEEKSPELWLNVIDEIIDMKYSDADSESINYLIIEKELVKMLDEVRKLYSNINDTNFNTQFAEILQEIVVFLGEDIIKATYPKYNQANYFNEVMQKMIDKLQYQNCISMRGLVQEFCGEYSIPIMTIHKSKGLEYHTVFFIGVEDDAFWSFSTQKEADKNAFFVALSRAKQKIIFTISEKRNILKFGEEKNILQETKNISELIQTLMDAGVPLIEKSGLDNIL
>CP028165.1|AVS03170.1|933246_935250_-|ATP-dependent-endonuclease
MLISELHISNFRSFGNESQMIEIADLTALIGANSSGKTSLIMALLRLFGQKNTDRTLIKTDFHIPESADISKINEIDLMIEAKVIFPELKLESPANIKTVPEFIKHLIIEETDADPYLRIRLKGKWIQGSTPEGNIEQELVYVKIPYGREEKEEDLTRVPIHHQKLIQMMYIPAMRDPAKQLKNASGTLLWRIFDGIDWPENLNDYIKSLTSPIETLFKEIPSIKDIQGILNNQWNKYHKDKRYSNSQFKFNGNSLQEFLKNAEILFNPTIDGNSVKVDSLGDGLKSLFYITLVSTLLEIENKQEKDDKPLLNILAIEEPENHISQHLLGRIVRNLKEISKKDNAQVILSSHNSSIIGKVDPEYIRHLQIQNSESIVNNITLPEKNDDAHTYIKEAVKAYPDLYFSKLVILGEGDSEEIVLPKLLSADNIYLDDFNISVVPLGGRYVNHMWKLLNDLSIPHVTLLDLDRERGGGDWGRIKYVLKQLDENNRCSEQLRTVLLIPSNTYHTYSMEEIEDFHNRKSNRLNSLNTWIEKLEKEDVFFSYPLDLDFTMLMSFQEEYQNTMERGPQIPKDSNSTEYDEKLKKSIQATLKNEKAIAKTYSEDEKKLMIWYNSLFLGRGKPSTHIAALKDIDENEIIENAPKELLRLIQRVKEKVGLVGGSNIDE
>CP028165.1|AVS03171.1|935401_937207_-|glutamine--fructose-6-phosphate-aminotransferase
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>CP028165.1|AVS03172.1|937887_939426_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIVGFKVLAPIMKFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQAAKVGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>CP028165.1|AVS03173.1|939460_941593_+|PTS-lactose-transporter-subunit-IIB
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGEDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQVSVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAEQLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNEFMASLVSDLSEFLSLKLESIDTFMEDPQELETLLRNKFLERIKKQFI
>CP028165.1|AVS03174.1|941604_942039_+|mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>CP028165.1|AVS03175.1|942038_943145_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

316481 : 324793

Staphylococcus_phage(16.67%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS02580.1\|316481_317267_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
AVS02581.1\|317392_318283_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
AVS02582.1\|318292_319639_-	DEAD/DEAH box family ATP-dependent RNA helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
AVS02583.1\|319752_320853_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	1.0e-08	30.6
AVS02584.1\|320855_321533_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
AVS02585.1\|321663_322770_-	RNA polymerase sigma factor SigA	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
AVS02586.1\|322993_324793_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	2.3e-53	35.8

DBSCAN-SWA_2

394446 : 403489

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS02656.1\|394446_394965_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	2.1e-28	45.8
AVS02657.1\|394986_397260_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	4.7e-64	29.5
AVS02658.1\|397462_399742_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
AVS02659.1\|400016_400277_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
AVS02660.1\|400295_401435_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
AVS02661.1\|401457_402483_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
AVS02662.1\|402484_403489_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_3

529011 : 647869

129

Staphylococcus_phage(87.27%)

protease,capsid,portal,transposase,tail,integrase,holin,head,tRNA,terminase

attL 584065:584080|attR 656900:656915

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS02772.1\|529011_535338_-	YSIRK signal domain/LPXTG anchor domain surface protein	A0A2H4PQU6	Staphylococcus_phage	1.9e-267	82.2
AVS02773.1\|535664_535976_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
AVS02774.1\|535997_538415_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.5
AVS02775.1\|538702_539884_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
AVS02776.1\|539993_540947_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
AVS02777.1\|540943_541507_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	1.2e-101	98.9
AVS02778.1\|541626_542028_-	MarR family transcriptional regulator	NA	NA	NA	NA
AVS02779.1\|542601_543429_-	alpha/beta hydrolase	NA	NA	NA	NA
AVS02780.1\|543431_543551_-	hypothetical protein	NA	NA	NA	NA
AVS02781.1\|543562_543754_-	hypothetical protein	NA	NA	NA	NA
AVS02782.1\|543662_544664_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
AVS02783.1\|544785_545250_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
AVS02784.1\|545262_546444_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	8.6e-227	99.5
AVS02785.1\|546454_547087_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.1e-111	98.6
AVS04868.1\|547093_548125_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.1e-196	99.1
AVS02786.1\|548617_550120_-	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	1.1e-29	98.6
AVS02787.1\|550641_550956_+	ArsR family transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	3.7e-52	96.2
AVS02788.1\|550955_552248_+	arsenical efflux pump membrane protein ArsB	A0A2H4PQU3	Staphylococcus_phage	1.0e-225	98.1
AVS02789.1\|552265_552661_+	protein ArsC	A0A2H4PQT9	Staphylococcus_phage	2.4e-72	99.2
AVS02790.1\|553009_553864_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
AVS02791.1\|554139_554364_-	hypothetical protein	NA	NA	NA	NA
AVS02792.1\|554562_555033_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	4.8e-80	96.8
AVS02793.1\|555145_555589_+	competence protein ComK	NA	NA	NA	NA
AVS02794.1\|555575_556019_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
AVS04869.1\|556316_556952_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AVS02795.1\|557377_558091_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
AVS02796.1\|558348_558651_+	hypothetical protein	NA	NA	NA	NA
AVS02797.1\|558906_559272_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.2e-59	98.3
AVS02798.1\|559268_559622_+	camphor resistance protein CrcB	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	99.1
AVS02799.1\|559871_560705_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	2.7e-158	99.3
AVS02800.1\|560916_561825_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	4.4e-138	99.7
AVS02801.1\|561968_563285_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	4.6e-43	32.8
AVS02802.1\|563454_564648_-	S-adenosylmethionine synthase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
AVS02803.1\|565019_566612_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
AVS04870.1\|566908_567655_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.6e-141	98.0
AVS02804.1\|567659_568133_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	6.1e-83	97.5
AVS02805.1\|568198_568456_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
AVS02806.1\|568452_569454_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	1.9e-182	96.7
AVS02807.1\|569458_570937_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	5.8e-281	97.2
AVS04871.1\|571095_571551_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	2.8e-77	96.6
AVS02808.1\|571853_572504_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	2.5e-50	78.7
AVS02809.1\|572584_573580_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	4.3e-70	95.6
AVS02810.1\|573655_574282_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	7.4e-76	80.8
AVS02811.1\|574322_574667_+	DUF3969 domain-containing protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	95.6
AVS02812.1\|574764_575337_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	3.2e-25	94.8
AVS02813.1\|575712_576549_+	ABC transporter ATP-binding protein	NA	NA	NA	NA
AVS02814.1\|576536_577241_+	hypothetical protein	NA	NA	NA	NA
AVS02815.1\|577355_577541_-	hypothetical protein	NA	NA	NA	NA
AVS02816.1\|577542_577719_-	hypothetical protein	NA	NA	NA	NA
AVS04872.1\|577729_578113_-	hypothetical protein	NA	NA	NA	NA
AVS02817.1\|578799_579246_-	DUF1433 domain-containing protein	NA	NA	NA	NA
AVS02818.1\|579697_579793_+	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
AVS02819.1\|579915_580017_+	hypothetical protein	NA	NA	NA	NA
AVS02820.1\|580679_584792_-	NTPase	A0A2H4PQT3	Staphylococcus_phage	0.0e+00	98.5
584065:584080	attL	NA	NA	NA	NA
AVS02821.1\|585554_586754_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	3.7e-225	97.7
AVS02822.1\|586746_588303_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	4.4e-287	98.8
AVS02823.1\|588656_589376_-\|protease	serine protease	A0A2H4PQP1	Staphylococcus_phage	8.9e-126	95.4
AVS02824.1\|589500_590220_-\|protease	serine protease	A0A2H4PQP7	Staphylococcus_phage	7.1e-115	86.6
AVS02825.1\|590277_591000_-\|protease	serine protease	A0A2H4PQN0	Staphylococcus_phage	3.5e-114	84.6
AVS02826.1\|591057_591780_-\|protease	serine protease	A0A2H4PQN0	Staphylococcus_phage	9.0e-126	94.6
AVS02827.1\|591904_592612_-\|protease	serine protease	A0A2H4PQN3	Staphylococcus_phage	8.2e-124	96.2
AVS02828.1\|593566_594148_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.9e-49	60.1
AVS02829.1\|595080_595554_+	hypothetical protein	NA	NA	NA	NA
AVS02830.1\|595558_596350_+	DUF1828 domain-containing protein	NA	NA	NA	NA
AVS02831.1\|596719_597703_-	leucotoxin LukDv	A0A2H4PQH7	Staphylococcus_phage	6.8e-185	98.8
AVS02832.1\|597704_598640_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.1e-171	98.4
AVS02833.1\|599520_599925_+	hypothetical protein	Q4ZCB9	Staphylococcus_virus	3.4e-58	82.1
AVS02834.1\|599988_600777_+	hypothetical protein	A0A2H4PQI0	Staphylococcus_phage	1.1e-140	95.4
AVS02835.1\|601646_601934_-	hypothetical protein	NA	NA	NA	NA
AVS02836.1\|602097_602562_+	hypothetical protein	A0EWV3	Staphylococcus_phage	6.1e-27	94.8
AVS02837.1\|603766_604771_-	hypothetical protein	A0A1W6JNN3	Staphylococcus_phage	8.0e-64	42.0
AVS02838.1\|604754_606647_-	adenine methyltransferase	A0A1W6JNK1	Staphylococcus_phage	1.9e-268	70.9
AVS02839.1\|607034_608480_-	autolysin	S4V6E6	Staphylococcus_phage	1.5e-289	97.7
AVS02840.1\|608460_608898_-\|holin	phage holin	A0A0K1LLA7	Staphylococcus_phage	6.5e-71	96.6
AVS02841.1\|608948_610961_-\|tail	phage tail protein	Q4ZA81	Staphylococcus_virus	0.0e+00	96.3
AVS02842.1\|610973_612848_-	CHAP domain-containing protein	Q4ZBX1	Staphylococcus_virus	0.0e+00	91.5
AVS02843.1\|612984_613284_-	hypothetical protein	B7T0E7	Staphylococcus_virus	2.5e-29	78.8
AVS04873.1\|613324_613498_-	XkdX family protein	Q8LTH6	Staphylococcus_phage	1.7e-27	100.0
AVS02844.1\|613507_613885_-	DUF2977 domain-containing protein	Q4ZA86	Staphylococcus_virus	2.6e-60	99.2
AVS02845.1\|613884_615708_-	hypothetical protein	Q4ZA88	Staphylococcus_virus	0.0e+00	99.5
AVS02846.1\|615707_617606_-	hypothetical protein	A0A059T5B2	Staphylococcus_phage	0.0e+00	98.1
AVS02847.1\|617618_619505_-	peptidase	A0A059T677	Staphylococcus_phage	0.0e+00	99.8
AVS02848.1\|619515_620457_-\|tail	phage tail protein	A0A059T7K5	Staphylococcus_phage	1.2e-178	98.4
AVS02849.1\|620471_623357_-\|terminase	terminase	M9NRJ5	Staphylococcus_phage	0.0e+00	95.8
AVS02850.1\|623360_623645_-	hypothetical protein	A0A059T626	Staphylococcus_phage	3.4e-44	97.9
AVS02851.1\|623689_624202_-	hypothetical protein	A0A059T5B1	Staphylococcus_phage	5.4e-93	100.0
AVS02852.1\|624268_624826_-\|tail	phage tail protein	A0A059T675	Staphylococcus_phage	4.1e-102	100.0
AVS02853.1\|624826_625252_-	DUF3168 domain-containing protein	Q4ZBQ9	Staphylococcus_phage	5.5e-75	100.0
AVS02854.1\|625264_625678_-	hypothetical protein	A0A0N9BAY5	Staphylococcus_phage	2.4e-75	99.3
AVS02855.1\|625664_626000_-\|head,tail	phage head-tail adapter protein	Q4ZBR2	Staphylococcus_phage	2.0e-59	99.1
AVS02856.1\|626011_626362_-\|head,tail	phage head-tail adapter protein	A0A0H3U2R5	Staphylococcus_phage	2.7e-59	98.3
AVS02857.1\|626522_627437_-\|capsid	phage major capsid protein	A0A059T7K3	Staphylococcus_phage	1.3e-169	99.3
AVS02858.1\|627453_628038_-	hypothetical protein	M9NRJ1	Staphylococcus_phage	9.9e-75	99.5
AVS02859.1\|628133_629084_-\|head	phage head morphogenesis protein	A0A0H3U2Z4	Staphylococcus_phage	2.3e-174	98.4
AVS02860.1\|629052_630477_-\|portal	phage portal protein	A0A0E3T9I6	Staphylococcus_phage	3.8e-269	98.3
AVS02861.1\|630473_631697_-\|terminase	PBSX family phage terminase large subunit	A0A059T7K2	Staphylococcus_phage	3.5e-239	99.0
AVS02862.1\|631689_632184_-\|terminase	terminase	A0A059T7P8	Staphylococcus_phage	4.9e-67	89.6
AVS02863.1\|632511_632934_-	DUF1492 domain-containing protein	A0A0F6N3E5	Staphylococcus_phage	1.2e-74	100.0
AVS02864.1\|632957_633104_-	hypothetical protein	A0A059T5A8	Staphylococcus_phage	2.2e-15	100.0
AVS02865.1\|633104_633470_-	hypothetical protein	A0A059T670	Staphylococcus_phage	1.6e-59	100.0
AVS02866.1\|633470_633644_-	transcriptional regulator	A0A059T7K1	Staphylococcus_phage	2.2e-22	100.0
AVS02867.1\|633645_633834_-	hypothetical protein	A0A059T7P6	Staphylococcus_phage	1.4e-27	98.4
AVS02868.1\|633830_634037_-	DUF1381 domain-containing protein	A0A059T622	Staphylococcus_phage	1.3e-21	100.0
AVS02869.1\|634073_634610_-	dUTPase	A0A1P8L6E0	Staphylococcus_phage	3.0e-94	98.9
AVS02870.1\|634602_634851_-	DUF1024 domain-containing protein	C8CH04	Staphylococcus_phage	1.6e-37	98.8
AVS02871.1\|635118_635529_-	hypothetical protein	A0A1P8CN10	Staphylococcus_phage	2.1e-47	69.1
AVS02872.1\|635542_635785_-	hypothetical protein	A0A2I6PDM0	Staphylococcus_phage	8.6e-41	97.5
AVS02873.1\|635788_636157_-	hypothetical protein	A0A0H4J337	Staphylococcus_phage	2.2e-51	98.4
AVS02874.1\|636157_636343_-	DUF3113 domain-containing protein	A0A059T620	Staphylococcus_phage	3.5e-26	96.7
AVS02875.1\|636347_636752_-	hypothetical protein	Q6R835	Staphylococcus_virus	8.7e-70	97.0
AVS02876.1\|636762_636984_-	DUF3269 domain-containing protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
AVS02877.1\|636986_637202_-	hypothetical protein	A9CR72	Staphylococcus_phage	1.2e-33	98.6
AVS02878.1\|637198_638440_-	damage-inducible protein	Q8SDW1	Staphylococcus_phage	1.2e-226	99.0
AVS02879.1\|638436_638793_-	hypothetical protein	M9NS37	Staphylococcus_phage	6.9e-63	99.2
AVS02880.1\|638792_639548_-	DnaD domain protein	C8CGZ1	Staphylococcus_phage	1.1e-129	91.2
AVS02881.1\|640228_640654_-	single-stranded DNA-binding protein	A0A0E3XC62	Staphylococcus_phage	4.0e-73	100.0
AVS02882.1\|640653_641292_-	single-stranded DNA-binding protein	R4II59	Staphylococcus_phage	1.7e-115	100.0
AVS02883.1\|641291_641771_-	siphovirus superfamily	Q4ZAD7	Staphylococcus_virus	3.4e-81	97.5
AVS02884.1\|641785_642046_-	DUF1108 domain-containing protein	Q4ZBM7	Staphylococcus_phage	1.2e-43	100.0
AVS02885.1\|642139_642301_-	DUF1270 domain-containing protein	A0A059T7J6	Staphylococcus_phage	4.3e-20	98.1
AVS02886.1\|642315_642531_-	DUF771 domain-containing protein	B7T098	Staphylococcus_virus	6.3e-35	100.0
AVS02887.1\|642543_643299_-	oxidoreductase	A0A1X9H0A0	Staphylococcus_phage	8.7e-140	100.0
AVS02888.1\|643300_643486_-	XRE family transcriptional regulator	A0A0H4IP57	Staphylococcus_phage	1.3e-25	100.0
AVS02889.1\|643931_644414_+	hypothetical protein	A0A0N9BAX2	Staphylococcus_phage	1.1e-82	100.0
AVS02890.1\|644647_644887_-	XRE family transcriptional regulator	A0A2H4J306	uncultured_Caudovirales_phage	3.0e-38	97.5
AVS02891.1\|645079_645412_+	XRE family transcriptional regulator	A0A1J0MFC1	Staphylococcus_phage	6.1e-37	73.6
AVS02892.1\|645423_645885_+	toxin	A0A2I6PEK4	Staphylococcus_phage	5.3e-63	80.8
AVS02893.1\|645916_646597_+	hypothetical protein	A0A2H4PQQ5	Staphylococcus_phage	5.7e-122	99.1
AVS02894.1\|646804_647869_+\|integrase	site-specific integrase	B7T092	Staphylococcus_virus	2.3e-202	99.2
656900:656915	attR	NA	NA	NA	NA

DBSCAN-SWA_4

791062 : 803332

Staphylococcus_phage(76.47%)

integrase,terminase,coat

attL 786436:786455|attR 801355:801374

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
786436:786455	attL	NA	NA	NA	NA
AVS03026.1\|791062_791632_-\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	5.1e-100	97.4
AVS04880.1\|791628_791841_-	pathogenicity island family protein	Q4ZE86	Staphylococcus_phage	3.3e-28	87.1
AVS03027.1\|791972_792500_-\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	1.2e-87	96.6
AVS03028.1\|792550_792769_-	hypothetical protein	NA	NA	NA	NA
AVS03029.1\|792786_793365_-	pathogenicity island protein	A0A2H4JBG0	uncultured_Caudovirales_phage	1.2e-27	38.4
AVS03030.1\|793376_793718_-	pathogenicity island protein	Q4ZE66	Staphylococcus_phage	8.4e-58	99.1
AVS03031.1\|794064_794706_-	pathogenicity island protein	Q4ZE67	Staphylococcus_phage	1.2e-110	92.5
AVS03032.1\|794702_795083_-	hypothetical protein	Q4ZE71	Staphylococcus_phage	4.5e-68	97.6
AVS03033.1\|795392_797102_-	DUF927 domain-containing protein	Q4ZE73	Staphylococcus_phage	5.1e-305	93.8
AVS03034.1\|797115_797985_-	mobile element-associated protein	Q4ZE74	Staphylococcus_phage	4.6e-161	94.1
AVS03035.1\|798051_798378_-	DUF1474 domain-containing protein	Q4ZE75	Staphylococcus_phage	8.9e-41	77.1
AVS03036.1\|798380_798590_-	pathogenicity island protein	Q4ZE76	Staphylococcus_phage	1.6e-30	98.6
AVS03037.1\|798582_798729_-	pathogenicity island protein	NA	NA	NA	NA
AVS03038.1\|798725_799043_-	helix-turn-helix domain-containing protein	A0A1W6JQE0	Staphylococcus_phage	1.7e-49	96.2
AVS03039.1\|799046_799259_-	XRE family transcriptional regulator	A0A1W6JQE8	Staphylococcus_phage	4.9e-24	82.8
AVS03040.1\|799421_800099_+	XRE family transcriptional regulator	A0A2H4JGT9	uncultured_Caudovirales_phage	1.2e-10	31.8
AVS03041.1\|800115_801288_+\|integrase	site-specific integrase	A0A1W6JQD3	Staphylococcus_phage	7.8e-220	98.7
AVS03042.1\|801356_802973_-	molecular chaperone GroEL	A0A240F779	uncultured_virus	1.5e-157	54.7
801355:801374	attR	NA	NA	NA	NA
AVS03043.1\|803047_803332_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2

DBSCAN-SWA_5

2282454 : 2290274

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS04373.1\|2282454_2283510_-	two-component sensor histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
AVS04374.1\|2283509_2284196_-	DNA-binding response regulator	NA	NA	NA	NA
AVS04375.1\|2284170_2284644_-	DoxX family protein	NA	NA	NA	NA
AVS04376.1\|2284985_2285426_-	hypothetical protein	NA	NA	NA	NA
AVS04377.1\|2285705_2286290_-	hypothetical protein	NA	NA	NA	NA
AVS04378.1\|2286388_2287102_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	5.0e-52	43.5
AVS04379.1\|2287105_2287525_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
AVS04380.1\|2287526_2288195_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
AVS04381.1\|2288545_2289139_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	5.8e-38	42.9
AVS04382.1\|2289122_2290274_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_6

2303751 : 2318353

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS04393.1\|2303751_2304810_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.3e-21	26.4
AVS04394.1\|2305104_2305653_+	5'(3')-deoxyribonucleotidase	NA	NA	NA	NA
AVS04395.1\|2305636_2305849_+	hypothetical protein	NA	NA	NA	NA
AVS04396.1\|2306254_2307172_-	lipid kinase	A0A1V0SBJ0	Catovirus	3.7e-07	22.4
AVS04397.1\|2307452_2308958_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
AVS04398.1\|2309019_2309268_-	hypothetical protein	NA	NA	NA	NA
AVS04399.1\|2309304_2309799_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.8e-52	71.5
AVS04400.1\|2309818_2310685_-	EamA/RhaT family transporter	NA	NA	NA	NA
AVS04401.1\|2311069_2311336_+	ribonucleoside-diphosphate reductase	NA	NA	NA	NA
AVS04402.1\|2311485_2311884_+	protein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
AVS04403.1\|2311846_2313952_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
AVS04404.1\|2314069_2315041_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
AVS04405.1\|2315486_2315642_+	hypothetical protein	NA	NA	NA	NA
AVS04940.1\|2315680_2316652_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
AVS04406.1\|2316638_2317595_+	iron ABC transporter permease	A0A2H4J116	uncultured_Caudovirales_phage	7.2e-06	60.0
AVS04407.1\|2317591_2318353_+	iron ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.0e-18	31.6

DBSCAN-SWA_7

2489130 : 2541158

Streptococcus_phage(33.33%)

holin,protease,tRNA,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS04572.1\|2489130_2490120_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
AVS04573.1\|2490414_2490810_+	transcriptional regulator Spx	NA	NA	NA	NA
AVS04574.1\|2491190_2491910_+	adaptor protein MecA	NA	NA	NA	NA
AVS04575.1\|2492030_2493017_+	competence protein CoiA	NA	NA	NA	NA
AVS04576.1\|2493064_2494873_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	5.5e-47	24.5
AVS04577.1\|2495333_2496140_-	DsbA family protein	NA	NA	NA	NA
AVS04578.1\|2496162_2496528_-	globin	NA	NA	NA	NA
AVS04579.1\|2496631_2497225_-	CYTH domain-containing protein	NA	NA	NA	NA
AVS04580.1\|2497410_2497758_+	hypothetical protein	NA	NA	NA	NA
AVS04581.1\|2497774_2498410_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
AVS04582.1\|2498426_2499236_+	NAD(+) kinase	NA	NA	NA	NA
AVS04583.1\|2499232_2500087_+	RluA family pseudouridine synthase	NA	NA	NA	NA
AVS04584.1\|2500107_2501493_+	magnesium transporter	NA	NA	NA	NA
AVS04585.1\|2501502_2503347_+	sodium:proton antiporter	NA	NA	NA	NA
AVS04586.1\|2503624_2504395_+	enoyl-[acyl-carrier-protein] reductase FabI	NA	NA	NA	NA
AVS04587.1\|2504590_2505676_-	AI-2E family transporter	NA	NA	NA	NA
AVS04588.1\|2506017_2507586_+	alanine:cation symporter family protein	NA	NA	NA	NA
AVS04589.1\|2507728_2508487_+	esterase family protein	NA	NA	NA	NA
AVS04590.1\|2508685_2509195_+	hypothetical protein	NA	NA	NA	NA
AVS04591.1\|2509307_2510516_-	MFS transporter	NA	NA	NA	NA
AVS04592.1\|2510475_2511651_-	diacylglycerol beta-glucosyltransferase	NA	NA	NA	NA
AVS04593.1\|2512083_2513568_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
AVS04594.1\|2513548_2513809_+	hypothetical protein	NA	NA	NA	NA
AVS04595.1\|2513808_2515371_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	2.2e-36	28.2
AVS04596.1\|2515672_2516476_+	hypothetical protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
AVS04597.1\|2516691_2519016_+	PDZ domain-containing protein	W5SAB9	Pithovirus	2.1e-11	27.4
AVS04598.1\|2519032_2520391_+	Ktr system potassium uptake protein D	NA	NA	NA	NA
AVS04599.1\|2520529_2522041_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
AVS04600.1\|2522529_2523099_-	competence protein ComK	NA	NA	NA	NA
AVS04601.1\|2523308_2523527_+	IDEAL domain-containing protein	NA	NA	NA	NA
AVS04602.1\|2523607_2524594_-	lipoate--protein ligase	NA	NA	NA	NA
AVS04603.1\|2524792_2524969_+	DUF2187 domain-containing protein	NA	NA	NA	NA
AVS04604.1\|2524983_2525586_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AVS04943.1\|2525887_2525965_+\|holin	putative holin-like toxin	NA	NA	NA	NA
AVS04944.1\|2526614_2526887_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
AVS04605.1\|2526930_2528895_+	DUF1430 domain-containing protein	NA	NA	NA	NA
AVS04606.1\|2528897_2529218_+	hypothetical protein	NA	NA	NA	NA
AVS04607.1\|2529214_2529856_+\|bacteriocin	bacteriocin ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.2e-19	33.7
AVS04608.1\|2529943_2530234_-	hypothetical protein	NA	NA	NA	NA
AVS04609.1\|2530374_2530512_+	poly(glycerol-phosphate) alpha-glucosyltransferase	NA	NA	NA	NA
AVS04610.1\|2530600_2530957_-	DoxX family protein	NA	NA	NA	NA
AVS04611.1\|2531445_2532405_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AVS04612.1\|2532450_2532582_-	hypothetical protein	NA	NA	NA	NA
AVS04613.1\|2532645_2532936_-	NINE protein	A0A060AN66	Enterococcus_phage	7.5e-07	38.0
AVS04614.1\|2533025_2533577_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
AVS04615.1\|2533627_2534566_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
AVS04946.1\|2534716_2534794_+	hypothetical protein	NA	NA	NA	NA
AVS04945.1\|2534897_2536109_+	isochorismate synthase	NA	NA	NA	NA
AVS04616.1\|2536095_2537769_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
AVS04617.1\|2537755_2538559_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
AVS04618.1\|2538551_2539373_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
AVS04619.1\|2539609_2539939_-\|protease	cysteine protease	NA	NA	NA	NA
AVS04620.1\|2539976_2541158_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA

DBSCAN-SWA_8

2561186 : 2569659

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVS04638.1\|2561186_2561669_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.2e-20	44.0
AVS04639.1\|2561655_2562780_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AVS04640.1\|2562783_2563488_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	2.8e-47	42.1
AVS04641.1\|2563487_2563751_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AVS04642.1\|2563752_2564424_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AVS04643.1\|2564416_2566606_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.3e-140	39.7
AVS04644.1\|2566584_2568069_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.5e-45	31.5
AVS04645.1\|2568061_2569090_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	6.5e-61	41.4
AVS04646.1\|2569092_2569659_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage