CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CWKV01000011	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000033	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000008	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	DinG,csa3	0	1	0
NZ_CWKV01000048	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000013	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000049	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000007	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000045	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000027	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000026	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	cas3	0	0	0
NZ_CWKV01000002	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000001	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000034	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000039	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000003	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	2 crisprs	cas8b2,cas7,cas5,cas3,cas2	11	0	0
NZ_CWKV01000029	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	DEDDh	0	1	0
NZ_CWKV01000014	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	DinG	0	0	0
NZ_CWKV01000036	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	cas3	0	0	0
NZ_CWKV01000037	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	WYL	0	0	0
NZ_CWKV01000021	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000025	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000047	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000017	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000046	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000031	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	casR	0	0	0
NZ_CWKV01000006	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	cas3	0	0	0
NZ_CWKV01000022	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	1	0
NZ_CWKV01000050	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000010	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000044	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000019	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000041	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000028	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000042	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000024	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000012	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000030	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000040	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000005	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	csa3	0	0	0
NZ_CWKV01000020	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	1	0
NZ_CWKV01000038	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000015	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000023	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	1 crisprs	NA	0	0	0
NZ_CWKV01000016	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000052	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000051	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000018	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000004	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	1	1
NZ_CWKV01000009	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	1 crisprs	csa3	0	1	0
NZ_CWKV01000035	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	WYL	0	0	0
NZ_CWKV01000032	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_CWKV01000043	Listeria monocytogenes isolate LM1, whole genome shotgun sequence	0 crisprs	NA	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12097 : 19519

Hokovirus(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014601906.1\|12097_13654_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.9e-17	28.1
WP_003721512.1\|13782_14187_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_003721511.1\|14246_14555_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_033918355.1\|14567_15392_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	9.7e-68	52.9
WP_003721509.1\|15403_16894_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
WP_010989660.1\|17102_18116_-	glycosyltransferase	A0A1V0SAH6	Catovirus	7.9e-11	32.0
WP_003721507.1\|18130_19114_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	3.1e-12	35.3
WP_003721506.1\|19135_19519_-	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CWKV01000008

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

39331 : 50058

Listeria_phage(40.0%)

tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009924934.1\|39331_40060_-	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	4.3e-35	42.5
WP_031669178.1\|40040_40463_-\|holin	holin family protein	Q2I8E7	Bacillus_phage	1.5e-27	46.3
WP_003721754.1\|40481_41018_-	hypothetical protein	NA	NA	NA	NA
WP_003721753.1\|41014_41494_-	hypothetical protein	NA	NA	NA	NA
WP_003721752.1\|41508_42084_-	hypothetical protein	NA	NA	NA	NA
WP_015453957.1\|42098_42398_-	hypothetical protein	NA	NA	NA	NA
WP_057171695.1\|42387_43524_-\|tail	phage tail protein	A0A0B5D0G3	Listeria_phage	1.7e-46	33.5
WP_057171696.1\|43533_44352_-\|tail	phage tail family protein	Q9T1A6	Listeria_phage	4.4e-44	35.5
WP_061112172.1\|44348_46217_-	hypothetical protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_072217178.1\|46203_46608_-	phenylalanine racemase	A0A097PAX1	Streptococcus_pyogenes_phage	2.4e-19	43.5
WP_003721745.1\|46649_46952_-	hypothetical protein	NA	NA	NA	NA
WP_003721744.1\|46999_47512_-\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_003733902.1\|47524_47914_-	DUF5072 family protein	NA	NA	NA	NA
WP_003732220.1\|48191_48608_-	hypothetical protein	NA	NA	NA	NA
WP_003732219.1\|48619_49048_-	hypothetical protein	A8ATZ8	Listeria_phage	3.0e-12	45.7
WP_003721740.1\|49264_49600_+	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003721739.1\|49605_50058_+	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CWKV01000029

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

10976 : 70532

Bacillus_virus(15.79%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003723562.1\|10976_12116_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_003723563.1\|12196_12592_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|12742_12958_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003732794.1\|13076_13610_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003732795.1\|13627_14293_+	hypothetical protein	NA	NA	NA	NA
WP_003732796.1\|14554_15493_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|15607_16891_+	trigger factor	NA	NA	NA	NA
WP_003723886.1\|17076_18336_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.4e-145	63.2
WP_003723887.1\|18454_19021_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_072225551.1\|19055_19625_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003723889.1\|19726_20269_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003723890.1\|20278_21142_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_003723891.1\|21138_21924_+	ribonuclease HII	G4YAY0	Emiliania_huxleyi_virus	3.0e-26	39.2
WP_003723892.1\|22057_22918_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	1.2e-39	43.2
WP_003732799.1\|23188_25267_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	3.2e-107	37.5
WP_003723999.1\|25329_26634_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_003724000.1\|26916_27819_+	tyrosine recombinase XerC	A0A1B1IQT7	uncultured_Mediterranean_phage	8.0e-23	28.0
WP_003724001.1\|27839_28379_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_072225552.1\|28392_29802_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IBU3	Erwinia_phage	1.2e-28	25.6
WP_003726695.1\|29822_30602_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_003724129.1\|30704_31124_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_003724130.1\|31145_31457_+	hypothetical protein	NA	NA	NA	NA
WP_003724131.1\|31459_32332_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_003724132.1\|32373_32970_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003732802.1\|33127_33535_+	CoA-binding protein	NA	NA	NA	NA
WP_003723731.1\|33715_35683_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	6.7e-123	42.5
WP_003723732.1\|35679_38139_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	1.1e-101	31.6
WP_003723733.1\|38221_38689_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_072225553.1\|39018_40860_+	lmo1289 family class 1 internalin	NA	NA	NA	NA
WP_003723735.1\|41191_42994_+	class 1 internalin InlK	NA	NA	NA	NA
WP_003723736.1\|43027_44896_-	peptidoglycan O-acetyltransferase OatA	B5WZU0	Pseudomonas_phage	6.5e-43	31.9
WP_003723737.1\|45108_45807_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	1.3e-12	32.4
WP_003723738.1\|46039_47716_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_003723739.1\|47841_48759_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|48881_49115_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_003733804.1\|49225_50449_+	GTPase HflX	NA	NA	NA	NA
WP_003723434.1\|50441_51668_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|51871_52240_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_003723435.1\|52310_53645_+	type I glutamate--ammonia ligase	M1NM71	Moumouvirus	4.2e-12	23.8
WP_033918375.1\|53788_55084_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	1.8e-145	61.9
WP_003723437.1\|55127_55649_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_003723438.1\|55678_56293_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_003723439.1\|56449_56779_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_003723440.1\|56870_57098_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_003723441.1\|57244_59239_+	transketolase	NA	NA	NA	NA
WP_003723442.1\|59459_59699_+	YneF family protein	NA	NA	NA	NA
WP_003723443.1\|59749_60592_-	DUF2785 domain-containing protein	NA	NA	NA	NA
WP_003723444.1\|60610_61342_-	methyltransferase domain-containing protein	A0A1X9I6N4	Streptococcus_phage	1.2e-80	59.1
WP_003723445.1\|61363_61870_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	4.0e-56	66.7
WP_072225554.1\|61879_63184_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	2.1e-133	52.1
WP_072217143.1\|63173_64379_-	helicase SNF2	L0P6E9	Lactobacillus_phage	3.7e-92	47.1
WP_003723448.1\|64356_64731_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|65023_65752_+	UMP kinase	NA	NA	NA	NA
WP_003723450.1\|65751_66309_+	ribosome recycling factor	NA	NA	NA	NA
WP_003723451.1\|66538_67297_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	1.1e-22	41.4
WP_003723452.1\|67310_68099_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_003723453.1\|68113_69256_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_003723454.1\|69269_70532_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_CWKV01000009

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CWKV01000009_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CWKV01000009_1

6846-7007

Orphan

Consensus_repeat	Method
TTTTTTTATGGAAACAACGCTCCACTTCGTTACGCCTTGTATTGGAGTTCTAGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CWKV01000009_1

>merge|NZ_CWKV01000009|1|6846-7007|CRISPRCasFinder
TTTTTTTATGGAAACAACGCTCCACTTCGTTACGCCTTGTATTGGAGTTCTAGGGGATTGGTTGAATTTAATAATTTGTGCTTCCTTTTTCGGGTTGTTCGTCCACTTTTTTTAATGGAAACAACGCTCCACTTCGTTACGCCTTGTATTGGAGTTCTAGGG

>NZ_CWKV01000009|1|1|6846-7007|CRISPRCasFinder
TTTTTTTATGGAAACAACGCTCCACTTCGTTACGCCTTGTATTGGAGTTCTAGGG	GATTGGTTGAATTTAATAATTTGTGCTTCCTTTTTCGGGTTGTTCGTCCACT
TTTTTTAATGGAAACAACGCTCCACTTCGTTACGCCTTGTATTGGAGTTCTAGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CWKV01000009.1\|WP_010989997.1\|13231_14422_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CWKV01000009.1\|WP_003723350.1\|3076_3541_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NZ_CWKV01000009.1\|WP_057171509.1\|15598_16645_-\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CWKV01000009.1\|WP_003732482.1\|7414_8158_-\|carboxylesterase	unknown	unknown	gnl\|CDD\|224561
NZ_CWKV01000009.1\|WP_003727926.1\|7081_7315_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|224233
NZ_CWKV01000009.1\|WP_003732483.1\|10896_12429_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|235463
NZ_CWKV01000009.1\|WP_033918293.1\|3556_5938_-\|ribonuclease-R	unknown	unknown	gnl\|CDD\|273947
NZ_CWKV01000009.1\|WP_009925021.1\|8340_9060_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CWKV01000009.1\|WP_003723352.1\|5971_6718_-\|carboxylesterase	unknown	unknown	gnl\|CDD\|224561
NZ_CWKV01000009.1\|WP_003727923.1\|9468_10761_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CWKV01000009.1\|WP_003732485.1\|14556_15567_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CWKV01000009.1\|WP_003772391.1\|9192_9366_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000009.1\|WP_003723925.1\|12430_13186_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NZ_CWKV01000009.1\|WP_140443144.1\|0_1726_-\|DUF4968-domain-containing-protein	unknown	unknown	gnl\|CDD\|269883
NZ_CWKV01000009.1\|WP_003723349.1\|2108_3017_+\|Rgg/GadR/MutR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045

Protein	Function_ID	Function_description	E-value
NZ_CWKV01000009.1\|WP_010989997.1\|13231_14422_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CWKV01000009.1\|WP_003723350.1\|3076_3541_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	2.29197e-92
NZ_CWKV01000009.1\|WP_057171509.1\|15598_16645_-\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	6.12803e-90
NZ_CWKV01000009.1\|WP_003732482.1\|7414_8158_-\|carboxylesterase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	1.94931e-122
NZ_CWKV01000009.1\|WP_003727926.1\|7081_7315_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|224233	COG1314, SecG, Preprotein translocase subunit SecG [Intracellular trafficking and secretion].	6.04836e-13
NZ_CWKV01000009.1\|WP_003732483.1\|10896_12429_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|235463	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0
NZ_CWKV01000009.1\|WP_033918293.1\|3556_5938_-\|ribonuclease-R	gnl\|CDD\|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NZ_CWKV01000009.1\|WP_009925021.1\|8340_9060_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.31126e-18
NZ_CWKV01000009.1\|WP_003723352.1\|5971_6718_-\|carboxylesterase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	3.8639e-136
NZ_CWKV01000009.1\|WP_003727923.1\|9468_10761_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CWKV01000009.1\|WP_003732485.1\|14556_15567_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CWKV01000009.1\|WP_003723925.1\|12430_13186_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	7.345e-145
NZ_CWKV01000009.1\|WP_140443144.1\|0_1726_-\|DUF4968-domain-containing-protein	gnl\|CDD\|269883	cd06597, GH31_transferase_CtsY, CtsY (cyclic tetrasaccharide-synthesizing enzyme Y)-like. CtsY is a bacterial 3-alpha-isomaltosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsZ. CtsY and CtsZ both have a glycosyl hydrolase family 31 (GH31) catalytic domain; CtsZ belongs to a different subfamily. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.	7.79999e-81
NZ_CWKV01000009.1\|WP_003723349.1\|2108_3017_+\|Rgg/GadR/MutR-family-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.22542e-08

>NZ_CWKV01000009.1|WP_003723352.1|5971_6718_-|carboxylesterase
MKITPPQPFLFEKGKRAVLLLHGFTGSSADVRILGRFLQENNYTCYAPQYRGHGVSPDLLLKTGPNDWWEDVLEAYDHLKSLGYTEIAVAGLSLGGLFSLKLGFSRPLKGIIAMSTPTRMDSSSPIIQGFLDYVRNYKKLEGKTTEQIDAEMVAYKDAPMNTIAKLKDEISGVVAEIDMIYAPIMVVQGEKDDMVDVSGAQLIYDTVESTKKELHWFKESGHVITLDKERKEVNQAILTFLDSLDWQE
>NZ_CWKV01000009.1|WP_033918293.1|3556_5938_-|ribonuclease-R
MEQKQMEEKIMNLLTSAPDKTFALEDLEIEIALNNADDFKLMVKALVKLEDSGTIVRSRKNRYALPEKMDLVKGTFRAHERGFGFVLPEEKEMDDIFIPPNEVKDAMNGDLVFATITKRKGDNLAEGTIKKIVERKTTQIVGTYMEDLAGIPIVMPDDKRLFGEVEIDLEDGLKPVDGHKVIVELTEYATGHARARGVVKSIIGHRNDPGVDILSIIHKHGISIGFPEEVMEQVSKAPDVVDDSDIGNRRDLRDQMIITIDGADAKDLDDAVTVKQLPNGNWKLGVHIADVTHYVTEGSPLDIEAQERGTSVYLVDRVIPMLPHKLSNGICSLNPQVDRFTMSCEMEIDQEGHVVNHEIFESIIKTTERMTYTDVNDILVEKDEALREKYAPIVPMLEAMQNLAEILRRKREKRGAIDFDFKEARVVVDEEGHPEAVVMRERSAGEHLIEEFMLAANETVAEHFHWMDVPFIYRIHEDPKEDKLARFFEFITNFGLIVKGTANDIHPAALQQVLEEVKGKPEEMVVSTVMLRSMQQAKYDTVSAGHFGLSTDFYTHFTSPIRRYPDLIVHRLIREYLINGDVRPETLEKRAEELPEIAEHSSKMERRAVEAERETDELKKTEFMVDKVGERFIGIISSVTNFGLFIELPTTIEGLVHVSAMKGDYFKFHQNQLAMIGERTGQIYRIGDEVEVEVTKVDVDAREIDFALRSEGKPGPVSDKQKRQREKPIDKTRNFKSSSKNNRNKRRTGKSEDVKPKTERKDDEWYTKPKKKKKKKPFYQGVAKESPKKKKRR
>NZ_CWKV01000009.1|WP_003723350.1|3076_3541_-|SsrA-binding-protein-SmpB
MPKGDGKLVAQNKKARHDYAIEETFEAGIVLQGTEIKSVRNARVNLKDSYARIDKGEIFLHNMHISPYEQGNRYNHDPLRTRKLLLHKKQISRLIGETKESGYSIVPLKMYIKDGYAKVLIGVARGKKKYDKRQDLKQKEAKRDIERAFKERQQ
>NZ_CWKV01000009.1|WP_003723349.1|2108_3017_+|Rgg/GadR/MutR-family-transcriptional-regulator
MQNVGDTLKFIRKSKNLTQQEACTGALSRSNYQKIENNKIMPSMDRFIQLLLNFNMTLEEFEFVKRDFTPSPKENILYLYSKIITSSETDILLDVISKCDEYLATQNDYFISDIKASLEGILLVEKEHDFELARQKVTYIWDRLSEADELFWNDILILRNIFFIFENETAQHIVNRLIKQLKKYRYLHPTLPIEISLHVNRATYLILDEKYELALHYIEQSIKIAKQNHYYLQFCMAIAKKGIVLYKLGQKQDGKRFMQRALRVAKFLEEERILNGIKNEIDYFLHDELPVLSLNEFTKIDI
>NZ_CWKV01000009.1|WP_140443144.1|0_1726_-|DUF4968-domain-containing-protein
MKRRTRKCSLVFILGILIFSCLSGFGTNVFAMDGEYHSPYGDDDLYSVQPTERSPRDPKAGEDVILNITTWPIEDGQNVWVEWTKNGVAQENVTAAYDYNSGNNTYWKADLGKFEKGDEITYTTKGSTNGGTAYESGPFTFYVTDWEYVQDVTSVVDNGDSITLNMTATAGDFSPKLYLSFEDLDTLRMELSPTGKETGHAGKSGYTVEDTAEKVTVTTEDLSIEIQKSPYRMEVHQADGTLLTSEYTTANSLGWLTDGKNVINQYQNNFMTPSDEAFYGFGERYDTINQRGKDVETYVYNEYQDQAQKERTYLAVPFFVSANKYGMYVNSDFHSQFQMASKVEDKYSFVLDNDGDMTNMLDYYVISGKDQNDIVNNYTDITGKTTLLPKWAFGLWMSANEWDRESDVSSALSNAKANDIPATGFVLEQWSDEETYYIWNNATYTAKKNGEAFSYDDFTFNGKWTDPKGMVDSVHDAGMNIVLWQVPVLKDDGTVYEQRDNDEAYMISQGYSADDGTGAPYRVPASQWFGNGILLDFTNKDAVDWWTSQREYLLTEVGIDGFKTDGGEMVWGRDT
>NZ_CWKV01000009.1|WP_003727926.1|7081_7315_-|preprotein-translocase-subunit-SecG
MSTVLTVLLIIVSVLLITVIILQPGKSAGLSGAISGGAEQLFGKQKARGLELILHRTTIVLSVVFFAILIALAYFVQ
>NZ_CWKV01000009.1|WP_003732482.1|7414_8158_-|carboxylesterase
MSADRSFTLKAGNRAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLEKDGYDEIAIVGVAMGGVFALKMAESFSPKAIVPLCANVNRKMRYIPIENYLTKQLKKQGIVEQEADQMLKNYLPEIDVMTEARATFYKNVARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTNDKQLCFYAGSGHDIVNDCEKDILEEDLIYFLDDLVWLEEKVV
>NZ_CWKV01000009.1|WP_009925021.1|8340_9060_-|alpha/beta-hydrolase
MIAEINGINLFYQIIGKGEPILLIHGNGQNHRSLKRMIDDLSTNHQVIAVDSRAHGKSEAGNTPLDFEVMALDMLSLLDYLKIDKYKVIGYSDGGIVALVMGKMQPNRQIASVVIGTNYHVNQIRFLPDLFCRVAYGAAFLLAPFSRFFERMKRQLALTIYHPHMSEADLQKISAPLLAVVGEYDLISSKDTRKMVHSVQHGEMVIVRNGLHYLPRQKPKQLLQLIHSFFSNLSAEIHK
>NZ_CWKV01000009.1|WP_003772391.1|9192_9366_-|hypothetical-protein
MLMKVKNSQASKVLETPKIKDAVVHEKSHPLAEKHSVQKKIINADMPQQQFHRRLMK
>NZ_CWKV01000009.1|WP_003727923.1|9468_10761_-|phosphopyruvate-hydratase
MSIITEVYAREVLDSRGNPTVEVEVYTEAGAFGRALVPSGASTGEYEAVELRDGDKARYLGKGVLKAVENVNDIIADKIIGFDVTDQIGIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELGVHLYEYLGGVNGKVLPVPMMNILNGGEHADNNVDVQEFMVMPVGAPNFKEALRMGAEILHALKAVLKGKGLNTGVGDEGGFAPNLKSNEEALETIMQAIKDAGYKPGEEVKLAMDAASSEFYNRETGKYELKGEGVTRTSEEMVTWYEEMITKYPIISIEDGLDENDWDGFKLLTERIGDRVQLVGDDLFVTNTTKLKEGIEKGIANSILIKVNQIGTLTETLDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTGAPTRTDRVAKYNQLLRIEDNLADLAEYHGNDTFYNLKK
>NZ_CWKV01000009.1|WP_003732483.1|10896_12429_-|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MSKSPVAIIILDGFGKRAETVGNAVAQANKPNFDRYWANFPHGELKAAGLDVGLPEGQMGNSEVGHTNIGAGRIVYQSLTRIDKAIEEGEFQENKALNNAFTHTKENNSDLHLFGLLSDGGVHSHINHLVALLETAKDKGVKNVYIHAFLDGRDVAPQSSLEYLETLEKAISDLNYGAIATVSGRFYAMDRDKRWERVEKAYKAIVSAEGEKFEDPIELVKASYANDKNDEFVVPAIITKDGKPVATVKDNDAVIFFNFRPDRAIQLSNAFTDKEWDHFDRGADHPKNIKFVTMTLYNPSVDAEVAFEPIEMKNVIGEVLSNEGLAQLRIAETEKYPHVTFFMNGGRNEEFPGESRILINSPKVETYDLQPEMSAYEVTDALVEDIKNDKHDAIILNFANPDMVGHSGMLEPTIKAIEAVDENLGRVVDLILEKGGSAIIFADHGNSETMSTPEGKPHTAHTTVPVPVIVTKKGVTLREGGRLADVAPTMLDLLGVKKPAEMTGESLIQK
>NZ_CWKV01000009.1|WP_003723925.1|12430_13186_-|triose-phosphate-isomerase
MRKPIIAGNWKMNKTAAKAGQFAEDVKNNVPSSDAVESVVAAPALFLQELVRLTEGTNLRVSAQNCYFEDEGAFTGEISPFALADLGVSYVIIGHSERREYFHETDEDINKKAHAIFKHGMTPIICCGETLDQREAGQTDTWVRGQIRAALAGLTEEQVIKSVIAYEPIWAIGTGKSSTSADANETCAVIRAEVADAVSQKAADAVRIQYGGSVKPENIADYLAESDIDGALVGGASLEPASFLALLEAVK
>NZ_CWKV01000009.1|WP_010989997.1|13231_14422_-|phosphoglycerate-kinase
MAKKVVTDLDLKDKKVLVRVDFNVPMKDGKITNDNRIVAALPTIEYILEQNGKAILFSHLGKVKTEEDKEGKSLRPVAVRLSELLGKEVKFVPTTRGPELEKAIDELKDGEVLLFENTRFEDIDGKKESKNDPELGKYWASLGDVFVNDAFGTAHRAHASNVGIASNLESAAGFLMEKEIKFIGGVVDNPARPLVAILGGAKVSDKIGVIENLLTKADKVLVGGGMTFTFMAAQGQEIGKSLLEADKVELAKGLLEKAGDKLVLPVDAVVSKEFSNDAPFHTVSADSIPADEMGLDIGQATIDLFTKELQGAKTVVWNGPMGVFELSNFAKGTIGVCEAIANLTDATTIIGGGDSAAAAMDLGFADKFTHISTGGGASLEYLEGKELPGVASISDK
>NZ_CWKV01000009.1|WP_003732485.1|14556_15567_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTVKVGINGFGRIGRLAFRRIQNVEGIEVVAINDLTDAKMLAHLLKYDTTQGRFDGEVEVHDGFFKVNGKEVKVLANRNPEELPWGDLGVDIVLECTGFFTAQDKAELHIKAGAKKVVISAPATGDMKTIVYNVNHETLDGTETVISGASCTTNCLAPMAKVLEDKFGVVEGLMTTIHAYTGDQNTLDAPHPKGDFRRARAAAENIIPNTTGAAKAIGEVLPTLKGKLDGAAQRVPVPTGSLTELVTVLDKKVTVDEVNAAMEAASDPETFGYTSDQVVSSDIKGMTFGSLFDETQTKVLTVGDQQLVKTVAWYDNEMSYTAQLVRTLEYFAKIAK
>NZ_CWKV01000009.1|WP_057171509.1|15598_16645_-|sugar-binding-transcriptional-regulator
MSDLINIQKKLLPDVLLIMQKRYQILRSIYFSEPVGRRTLAGMLGMSERVLRGEVEFLKAQGLVEIASSGMTVTKEGLVVFRDLENVMNQLSGLHSMEEQLAKKLQIKKCLVVQGDSDDTPWVREEMGRVAVEQLDMALTEKRNIVAVMGGSTMATVAEMMTTDFAKGRELLFVPGRGGIGEDLDNQANTICDKMATKTNTKHRVLYVPEQLGEEAYRSLLKEPAIQEGLRLVQSANAIILGIGDALAMAKRRHTGEDVLGKIIHRKAVGEAFGYYFDEQGEVVHKVPTFGLQFEDLAQIPHIIAVAGGTSKAKAIKSYMKSAPKNTILITDEGAAKSLLKGSNTLLK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

29772 : 37616

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722604.1\|29772_30744_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
WP_003722605.1\|30751_31720_-	YvcK family protein	A1IMD5	Streptococcus_phage	6.7e-68	43.3
WP_003722606.1\|31721_32597_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.9e-08	29.7
WP_033918280.1\|32704_34435_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	3.0e-175	54.0
WP_003734087.1\|34476_35538_-	galactose mutarotase	NA	NA	NA	NA
WP_009924988.1\|35554_36538_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	3.1e-52	38.4
WP_003722610.1\|36656_37616_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_CWKV01000020

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2922 : 11208

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722250.1\|2922_4215_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	7.2e-17	32.6
WP_003722249.1\|4295_5009_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.7e-42	38.7
WP_003722248.1\|5020_5266_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_003722247.1\|5269_5953_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003722246.1\|5945_8165_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.6e-160	41.4
WP_003722245.1\|8149_9577_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-53	34.6
WP_003722244.1\|9595_10645_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.0e-61	43.2
WP_003722243.1\|10641_11208_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_CWKV01000023

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CWKV01000023_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CWKV01000023_1

32803-33381

Orphan

Consensus_repeat	Method
GATGTAAGTNATTTTGATACNAGTTCAGTAACT	CRT

7 spacers

The CRISPR arrays of NZ_CWKV01000023_1

>merge|NZ_CWKV01000023|1|32803-33381|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATGTGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTGGATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATGTCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTGGATGTAAGCAACCTTGATACGAGTTCAGTAACTAATATGTATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTGGATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTAGATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTGGATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGTGTTAGATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATGGCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTTGATTTAAGTACCTTTGATACCAGTTCAGTGACT

>NZ_CWKV01000023|1|1|32803-33381|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACT	ACTATGTGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTG
GATGTAAGTCATTTTGATACAAGTTCAGTAACT	AATATGTCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTG
GATGTAAGCAACCTTGATACGAGTTCAGTAACT	AATATGTATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTG
GATGTAAGTCATTTTGATACGAGTTCAGTAACT	GATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTA
GATGTAAGTAATTTCGATACCAGTTCCGCTACT	GCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTG
GATGTAAGTAATTTTAATACGAGCTTAGTAACT	GATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGTGTTA
GATGTAAGTAATTTTGATACGAGTTCAGTAACT	AATATGGCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTT
GATTTAAGTACCTTTGATACCAGTTCAGTGACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CWKV01000023.1\|WP_057171529.1\|25780_27331_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_CWKV01000023.1\|WP_003721249.1\|28150_29689_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NZ_CWKV01000023.1\|WP_003721253.1\|34773_35259_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000023.1\|WP_010989475.1\|21674_23270_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_CWKV01000023.1\|WP_003721245.1\|24687_25788_+\|DUF917-domain-containing-protein	unknown	unknown	gnl\|CDD\|226065
NZ_CWKV01000023.1\|WP_012581921.1\|20571_21519_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CWKV01000023.1\|WP_003721255.1\|35667_35934_+\|transposase	unknown	unknown	unknown
NZ_CWKV01000023.1\|WP_009930717.1\|16389_17145_-\|DUF4866-domain-containing-protein	unknown	unknown	gnl\|CDD\|379782
NZ_CWKV01000023.1\|WP_010989473.1\|19418_20567_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CWKV01000023.1\|WP_003733941.1\|35286_35592_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_CWKV01000023.1\|WP_003721252.1\|34280_34754_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000023.1\|WP_003721256.1\|36474_36759_+\|DUF3130-domain-containing-protein	unknown	unknown	gnl\|CDD\|288220
NZ_CWKV01000023.1\|WP_072225541.1\|36759_37122_+\|ribonuclease-P	unknown	unknown	unknown
NZ_CWKV01000023.1\|WP_003721244.1\|23403_24687_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NZ_CWKV01000023.1\|WP_003721250.1\|29940_32010_+\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NZ_CWKV01000023.1\|WP_057171530.1\|17262_19422_-\|transglutaminase	unknown	unknown	gnl\|CDD\|376628

Protein	Function_ID	Function_description	E-value
NZ_CWKV01000023.1\|WP_057171529.1\|25780_27331_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.32348e-105
NZ_CWKV01000023.1\|WP_003721249.1\|28150_29689_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	1.08327e-19
NZ_CWKV01000023.1\|WP_010989475.1\|21674_23270_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.08474e-59
NZ_CWKV01000023.1\|WP_003721245.1\|24687_25788_+\|DUF917-domain-containing-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NZ_CWKV01000023.1\|WP_012581921.1\|20571_21519_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	3.27176e-102
NZ_CWKV01000023.1\|WP_009930717.1\|16389_17145_-\|DUF4866-domain-containing-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	3.03926e-122
NZ_CWKV01000023.1\|WP_010989473.1\|19418_20567_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	2.48336e-53
NZ_CWKV01000023.1\|WP_003733941.1\|35286_35592_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	4.04229e-05
NZ_CWKV01000023.1\|WP_003721256.1\|36474_36759_+\|DUF3130-domain-containing-protein	gnl\|CDD\|288220	pfam11328, DUF3130, Protein of unknown function (DUF3130. This bacterial family of proteins has no known function.	4.16867e-42
NZ_CWKV01000023.1\|WP_003721244.1\|23403_24687_+\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	6.12636e-95
NZ_CWKV01000023.1\|WP_003721250.1\|29940_32010_+\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	1.08206e-30
NZ_CWKV01000023.1\|WP_057171530.1\|17262_19422_-\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	1.38784e-27

>NZ_CWKV01000023.1|WP_003721250.1|29940_32010_+|BspA-family-leucine-rich-repeat-surface-protein
MKKLSMRVILIVTVIFIACGSANVSIAQEMDIANKLPEEELGSLDTSNVNTEGVPQDKSAEVENLEEIPITDDLEQNPDVLEQPVADSDDSDLTVVDSGAYWTIYHNTANGEYSLHMFGNVPSSKPTAWNSYLNSIKHIEIEEATLIGDFSSYFRSFFFTALESVRIERSNLSGVKSFALAFYSSGIEKVIIRDNDYSTAPSLLTTEGMFKNCSNLTELDLSGLDTSAVTTMRDMFYSCSALEELDVSHFDTSSVTNMSYLFYDNEKLEKLDVSNFDTSLVTNMYAMFANCTSLEELDVSNFDTSSATDIYRMFESCVKLKKLDVSNFDTSSVTDMAYMFRNCSTLEKLDVSNFNTSSVTSMRAMFAGCTSLEALDISNFDTSSVTDMASMFLTCTSLEELDLSTFDTSLVDFMGYMFKDCTNLKTLYLNNFTDAASTIDMFTGTTSLTYLFVSHNFKVFNGLEDTNWYDEKNWVQFETVWQLQTYHWRQSEPIGYRKGAFLSLTMDAMGGQFEDMEEQKVQNKVFGDYWEEMLPVKDGHYFDGWYLDQYFTSKFDFSLPADASITIYAKWIENYTVVIPASIFLNETSELKVEGINRGDKTLSVGLNRTATSISESNELTLANTADTTVQCLAPLSWDGSENNPKNAILTLAPGSEITEGDAVMEIESPENIQAGKYTGNLVFSINYE
>NZ_CWKV01000023.1|WP_003721249.1|28150_29689_+|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELRERNLSISTGNQVEITGDEFSLRIFYAFLFLVTYSGDRWPFSFVQYDEITDLLESCPKEIYRANSIDKGMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEITYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASERVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINRFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMRLLKPFEERLASDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIVYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NZ_CWKV01000023.1|WP_057171529.1|25780_27331_+|hydantoinase/oxoprolinase-family-protein
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGANIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVRENDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGVAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVVQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NZ_CWKV01000023.1|WP_003721245.1|24687_25788_+|DUF917-domain-containing-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTNSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NZ_CWKV01000023.1|WP_003721244.1|23403_24687_+|cytosine-permease
MTEKKTVEQAQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVVFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPILLFVCIYGLVVSLNNGGLAVVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMIAVGAILALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAIAGGLGTVLAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVPGVNWLGVTSWLVGAVIAGIPVILTFFPALPQLPNQPLIGIILSLAVYLVGAKVLSGKTNNVENLEGK
>NZ_CWKV01000023.1|WP_010989475.1|21674_23270_+|PucR-family-transcriptional-regulator
MSVKLADLMKLPSLKEAKVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIRDDVEAQCRTIERLHKVGEVALILYYVGIFVPKMDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHSSLVLTDNSFQVINSITWPRTRHWDFERVIETSKQIDEHELVQLHLDERDFYTARKPIFQDGMQAMHLFMMKEKGALTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRNNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVGQRDRTHTANEFAMMMKEHGIDLKITVCQGMEQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKSLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRLLGGNNNNK
>NZ_CWKV01000023.1|WP_012581921.1|20571_21519_-|MoxR-family-ATPase
MSIEPSIKINEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTQQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NZ_CWKV01000023.1|WP_010989473.1|19418_20567_-|DUF58-domain-containing-protein
MLKKRLLLASRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRSFVKNTYHDGDLIDMQVSFTRKSRYPVGYLLFQQKIPATFGKVRARQQVVYPLFKKQFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPNVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEENGEIRVTLLGDQTSKFAPAKGTSRLQDISTAFAEIAPVDSLTLQESLDSNLHSGEKILLFTPCMDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEQASLLSRWERETK
>NZ_CWKV01000023.1|WP_057171530.1|17262_19422_-|transglutaminase
MKRYLTLVMLFILSVLLISEWIYPFAELTELSTATWIILFITLSLGSFFLRLKYYWTIPLHVVMIIIVSGIYYAKGGILAGNWLGSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRIMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIAAPNRISADSLKRNGLFYHIFVILLLAVFVFSSLMLPKKAPIFPDPIPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTARAEKGHYWRVESKTVYTGTGWANANSGDVISFSSGDNFPIQLTEKTTGATNTAEISFASSSDYMPYPYGTQAVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNTFVSQYTQTPKDLPDRVTKLANKVTKDADSIYDKTKAIEHYLSASGTFTYSTDDAKETPRGADYVDQFLFETQIGYCDNFSTSMVVMLRTLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTPDKTPEQDNGSSSTGETPKKEEPKTETATSNVEIPSWVWWIPAGLVVALLALAIVFRRRIRGYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSARVDADLTTSEFSRLTKMYETQLYSKNLTEKVIAAEETQLVQQIIARLTK
>NZ_CWKV01000023.1|WP_009930717.1|16389_17145_-|DUF4866-domain-containing-protein
MTTIFPKEQNVTPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIVHSYEPDFSISTKRINKKRGILVLYSLPDTLKSGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK
>NZ_CWKV01000023.1|WP_003721252.1|34280_34754_+|hypothetical-protein
MKKKRVVIISLLLLLVSVIGISSYFLFKDKINLLDVDHSAVDWNGKKQKDTSGEENTIAIPGFEKVTLYANETKQAVNFHNPEINDCYFKISLIHPDGSVLWISDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NZ_CWKV01000023.1|WP_003721253.1|34773_35259_+|hypothetical-protein
MNKLVLSTLSVAAMGMVFFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELQRVGAISDVITSSFKSNNSVVPMANPVIGSFSGYAMEETEVSKIQIGNPQGDKKAGAYQTTLTFTAAFK
>NZ_CWKV01000023.1|WP_003733941.1|35286_35592_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQHMLPKAGDTVTNYTLLGLVLVLIWLIMQRKRKKKE
>NZ_CWKV01000023.1|WP_003721255.1|35667_35934_+|transposase
MARIEYGEEIQKSLLVLYSRGSTIDSICKEYGIPRYEFHKWMKLHDADKLETKEVKTLLQIRELKQQKNKLEEEILFLNEAINLLESP
>NZ_CWKV01000023.1|WP_003721256.1|36474_36759_+|DUF3130-domain-containing-protein
MREIKVDERTFQQHATKLASESTGSYLPLKNGNMAYSRANSIDQLRSALIELVDVVEDFQHVTKKDASRLKKMGIAYAKQDQLMGQKINQLEVR
>NZ_CWKV01000023.1|WP_072225541.1|36759_37122_+|ribonuclease-P
MDSAHSQLEQQLQQIKKAKITAETDADQTRRKQNEQDWLEEDSNQLTQEKRVLLDFLRSGWQGEEASGFHRYLEEQQHEESQAWRRDLQDKRADLDTELQENKDKLHTLETKQATLQKEWS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_CWKV01000004

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

501 : 37806

Listeria_phage(94.23%)

tail,integrase,terminase,holin

attL 377:426|attR 38231:38280

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
377:426	attL	NA	NA	NA	NA
WP_072225504.1\|501_1677_-\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	2.0e-50	31.3
WP_003724017.1\|1739_2345_-	hypothetical protein	NA	NA	NA	NA
WP_003724016.1\|2403_3111_-	hypothetical protein	A0A0B5CTT6	Listeria_phage	2.8e-124	100.0
WP_003724015.1\|3125_3551_-	ImmA/IrrE family metallo-endopeptidase	A0A0B5CTZ7	Listeria_phage	2.2e-76	100.0
WP_003724014.1\|3566_3989_-	helix-turn-helix transcriptional regulator	A0A0B5CYL9	Listeria_phage	7.7e-69	98.6
WP_003733688.1\|4154_4364_+	helix-turn-helix domain-containing protein	A0A0B5D0D3	Listeria_phage	3.5e-30	95.6
WP_003733687.1\|4384_4579_+	hypothetical protein	A0A059T6E5	Listeria_phage	1.4e-25	95.3
WP_003733686.1\|4590_4875_+	hypothetical protein	A0A0B5D168	Listeria_phage	4.5e-41	85.1
WP_003722567.1\|4900_5182_+	hypothetical protein	A8ATX8	Listeria_phage	1.8e-37	95.7
WP_003733684.1\|5183_5381_-	hypothetical protein	Q9T179	Listeria_phage	4.0e-20	96.0
WP_003733683.1\|5444_6221_+	phage antirepressor Ant	A0A0B5D0I2	Listeria_phage	6.9e-140	97.7
WP_003733682.1\|6344_6875_+	hypothetical protein	A0A0B5D173	Listeria_phage	2.7e-79	89.6
WP_031644321.1\|6864_7071_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_003725088.1\|7172_7361_+	hypothetical protein	Q9T175	Listeria_phage	6.9e-22	79.0
WP_077947174.1\|7596_8556_+	YqaJ viral recombinase family protein	A8ATY5	Listeria_phage	1.8e-177	99.1
WP_010991173.1\|8558_9374_+	recombinase RecT	A8ATY6	Listeria_phage	3.5e-150	98.9
WP_072225505.1\|9393_10326_+	DnaD domain-containing protein	A8ATY7	Listeria_phage	4.3e-165	97.7
WP_003722560.1\|10322_11135_+	DNA adenine methylase	Q8W5X3	Listeria_phage	4.8e-152	95.6
WP_072225506.1\|11131_11692_+	DUF1642 domain-containing protein	A8ATY9	Listeria_phage	7.5e-72	75.3
WP_014929526.1\|11688_11835_+	hypothetical protein	A8ATZ0	Listeria_phage	1.7e-20	100.0
WP_014601510.1\|11912_12314_+	hypothetical protein	A8ATD9	Listeria_phage	2.6e-74	100.0
WP_014601509.1\|12310_12520_+	hypothetical protein	A8ATE0	Listeria_phage	1.7e-32	100.0
WP_009930868.1\|12520_12688_+	hypothetical protein	NA	NA	NA	NA
WP_009930870.1\|12684_13221_+	hypothetical protein	D9J0I6	Brochothrix_phage	2.3e-09	31.7
WP_003733723.1\|13399_13654_+	hypothetical protein	A0A059T5G2	Listeria_phage	3.4e-40	92.8
WP_025370642.1\|13654_14137_+	single-stranded DNA-binding protein	A8ASP5	Listeria_phage	1.6e-70	83.8
WP_025370641.1\|14158_14341_+	hypothetical protein	A8ASP6	Listeria_phage	3.6e-15	79.3
WP_003733720.1\|14330_14828_+	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	1.8e-32	49.3
WP_025370640.1\|14892_15327_+	hypothetical protein	A8ASQ1	Listeria_phage	3.1e-57	76.4
WP_003733718.1\|15602_15830_+	hypothetical protein	A0A0B5CTV3	Listeria_phage	2.4e-32	94.7
WP_003733717.1\|15873_16599_+	helix-turn-helix domain-containing protein	A0A0B5CTX0	Listeria_phage	4.4e-80	68.5
WP_045131573.1\|16564_17911_+\|terminase	PBSX family phage terminase large subunit	A0A0B5CYJ6	Listeria_phage	1.5e-251	93.6
WP_023552450.1\|17925_19485_+	hypothetical protein	A0A0B5D0A6	Listeria_phage	3.1e-293	97.3
WP_039380729.1\|19489_20533_+	hypothetical protein	A0A0B5D111	Listeria_phage	1.6e-195	97.4
WP_003744996.1\|20628_21183_+	hypothetical protein	A8ATU9	Listeria_phage	1.1e-88	99.5
WP_015987427.1\|21205_22078_+	F420-dependent oxidoreductase	A8ATV0	Listeria_phage	1.2e-161	100.0
WP_172425835.1\|22091_22259_+	hypothetical protein	A8ATV1	Listeria_phage	1.7e-11	100.0
WP_012951937.1\|22259_22613_+	hypothetical protein	A8ATV2	Listeria_phage	7.6e-62	100.0
WP_015987430.1\|22612_22978_+	hypothetical protein	A8ATV3	Listeria_phage	4.4e-65	100.0
WP_015987407.1\|22967_23285_+	HK97 gp10 family phage protein	A8ATV4	Listeria_phage	9.9e-53	100.0
WP_003725064.1\|23281_23653_+	hypothetical protein	A8ATV5	Listeria_phage	8.5e-64	100.0
WP_015987408.1\|23657_24344_+	Ig domain-containing protein	A8ATV6	Listeria_phage	9.4e-117	100.0
WP_015987409.1\|24399_24831_+	hypothetical protein	A8ATV7	Listeria_phage	9.6e-75	100.0
WP_072225507.1\|24827_25139_+	hypothetical protein	A8ATV8	Listeria_phage	1.2e-42	98.9
WP_072225508.1\|25143_29943_+\|tail	phage tail tape measure protein	A8ATV9	Listeria_phage	0.0e+00	99.7
WP_003731724.1\|29939_31508_+\|tail	phage tail family protein	A8ATW0	Listeria_phage	4.7e-305	99.6
WP_072225509.1\|31520_33686_+\|tail	phage tail protein	A8ATW1	Listeria_phage	0.0e+00	94.3
WP_003722523.1\|33724_34090_+	hypothetical protein	Q9T1A0	Listeria_phage	7.4e-12	100.0
WP_003722522.1\|34102_34384_+\|holin	holin	A8ASL4	Listeria_phage	3.4e-41	94.6
WP_003733663.1\|34383_35229_+	M15 family metallopeptidase	A0A059T7Y8	Listeria_phage	2.7e-137	94.7
WP_003722520.1\|35269_36043_-	DUF3825 domain-containing protein	A8ATW5	Listeria_phage	9.5e-150	100.0
WP_003733661.1\|36317_36815_-	AP2 domain-containing protein	A8ATW6	Listeria_phage	3.8e-91	100.0
WP_003722518.1\|36839_37289_-	anti-CRISPR protein AcrIIA1	A8ATW7	Listeria_phage	2.4e-76	100.0
WP_003731276.1\|37289_37541_-	hypothetical protein	A8ATW8	Listeria_phage	2.0e-40	100.0
WP_003731277.1\|37572_37806_-	hypothetical protein	A8ATW9	Listeria_phage	4.3e-13	100.0
38231:38280	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CWKV01000004.1|WP_003731276.1|37289_37541_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CWKV01000004.1|WP_003731276.1|37289_37541_-|hypothetical-protein

37289_37541_-

83 aa aa

AcrIIA12

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3641\|WP_003731276.1\|AcrIIA12\|II-A\|Verified\|Listeria-monocytogenes	1.0	1	1.0

501-37806

8. NZ_CWKV01000003

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CWKV01000003_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CWKV01000003_1

32702-32984

Unclear

I-A

Consensus_repeat	Method
GTTTTAGTTACTTATTTTGAAATGTAAAT	PILER-CR
GTTTTAGTTACTTATTTTGAAATGTAAAT	CRISPRCasFinder
GTTTTAGTTACTTATTTTGAAATGTAAAT	CRT

4 spacers

cas6,cas8b2

The CRISPR arrays of NZ_CWKV01000003_1

>merge|NZ_CWKV01000003|1|32702-32984|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTTACTTATTTTGAAATGTAAATAAACAGAAATGAAAGATGGTGAAGAAGTCCTTACCGTTTTAGTTACTTATTTTGAAATGTAAATTTTTTTAAGGCAAGTGTCATCGTTTCTAATCCGCGTTTTAGTTACTTATTTTGAAATGTAAATCTAGAACAAAAGAAAAATCATGAGGGATATTTACGTTTTAGTTACTTATTTTGAAATGTAAATGGTTTTGAATGCTGGTGGTGATAGTCCTAATGAAGGTTTTAGTTACTTATTATGAAATGTAAAT

>NZ_CWKV01000003|1|1|32702-32984|PILER-CR
GTTTTAGTTACTTATTTTGAAATGTAAAT	AAACAGAAATGAAAGATGGTGAAGAAGTCCTTACC
GTTTTAGTTACTTATTTTGAAATGTAAAT	TTTTTTAAGGCAAGTGTCATCGTTTCTAATCCGC
GTTTTAGTTACTTATTTTGAAATGTAAAT	CTAGAACAAAAGAAAAATCATGAGGGATATTTAC
GTTTTAGTTACTTATTTTGAAATGTAAAT	GGTTTTGAATGCTGGTGGTGATAGTCCTAATGAAG
GTTTTAGTTACTTATTATGAAATGTAAAT

>NZ_CWKV01000003|1|1|32702-32984|CRISPRCasFinder
GTTTTAGTTACTTATTTTGAAATGTAAAT	AAACAGAAATGAAAGATGGTGAAGAAGTCCTTACC
GTTTTAGTTACTTATTTTGAAATGTAAAT	TTTTTTAAGGCAAGTGTCATCGTTTCTAATCCGC
GTTTTAGTTACTTATTTTGAAATGTAAAT	CTAGAACAAAAGAAAAATCATGAGGGATATTTAC
GTTTTAGTTACTTATTTTGAAATGTAAAT	GGTTTTGAATGCTGGTGGTGATAGTCCTAATGAAG
GTTTTAGTTACTTATTATGAAATGTAAAT

>NZ_CWKV01000003|1|1|32702-32984|CRT
GTTTTAGTTACTTATTTTGAAATGTAAAT	AAACAGAAATGAAAGATGGTGAAGAAGTCCTTACC
GTTTTAGTTACTTATTTTGAAATGTAAAT	TTTTTTAAGGCAAGTGTCATCGTTTCTAATCCGC
GTTTTAGTTACTTATTTTGAAATGTAAAT	CTAGAACAAAAGAAAAATCATGAGGGATATTTAC
GTTTTAGTTACTTATTTTGAAATGTAAAT	GGTTTTGAATGCTGGTGGTGATAGTCCTAATGAAG
GTTTTAGTTACTTATTATGAAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CWKV01000003.1\|WP_003721290.1\|27690_28089_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000003.1\|WP_003721299.1\|35132_35591_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
NZ_CWKV01000003.1\|WP_003721300.1\|35972_37808_+\|lmo0514-family-class-1-internalin	unknown	unknown	gnl\|CDD\|380190
NZ_CWKV01000003.1\|WP_003721298.1\|34766_35126_-\|Lin0512-family-protein	unknown	unknown	gnl\|CDD\|131113
NZ_CWKV01000003.1\|WP_003721287.1\|24512_26573_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CWKV01000003.1\|WP_003721294.1\|30116_31388_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CWKV01000003.1\|WP_009930754.1\|33375_33954_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000003.1\|WP_003721301.1\|37908_38340_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CWKV01000003.1\|WP_003721288.1\|26576_27179_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NZ_CWKV01000003.1\|WP_003721289.1\|27206_27674_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NZ_CWKV01000003.1\|WP_003721305.1\|41842_43531_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NZ_CWKV01000003.1\|WP_003721291.1\|28099_28750_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_CWKV01000003.1\|WP_003721297.1\|34061_34742_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CWKV01000003.1\|WP_003721286.1\|23753_24404_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NZ_CWKV01000003.1\|WP_003721304.1\|41104_41827_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CWKV01000003.1\|WP_003721303.1\|39937_40753_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CWKV01000003.1\|WP_003721295.1\|31527_32463_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CWKV01000003.1\|WP_003721302.1\|38386_39817_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_CWKV01000003.1\|WP_003721292.1\|28746_29793_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CWKV01000003.1\|WP_003721293.1\|29808_30102_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908

Protein	Function_ID	Function_description	E-value
NZ_CWKV01000003.1\|WP_003721299.1\|35132_35591_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	8.31646e-13
NZ_CWKV01000003.1\|WP_003721300.1\|35972_37808_+\|lmo0514-family-class-1-internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.95498e-119
NZ_CWKV01000003.1\|WP_003721298.1\|34766_35126_-\|Lin0512-family-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	5.62162e-67
NZ_CWKV01000003.1\|WP_003721287.1\|24512_26573_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	2.1337e-80
NZ_CWKV01000003.1\|WP_003721294.1\|30116_31388_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178
NZ_CWKV01000003.1\|WP_003721301.1\|37908_38340_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NZ_CWKV01000003.1\|WP_003721288.1\|26576_27179_+\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	1.67992e-75
NZ_CWKV01000003.1\|WP_003721289.1\|27206_27674_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	3.45565e-37
NZ_CWKV01000003.1\|WP_003721305.1\|41842_43531_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	5.75294e-26
NZ_CWKV01000003.1\|WP_003721291.1\|28099_28750_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	4.74405e-108
NZ_CWKV01000003.1\|WP_003721297.1\|34061_34742_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	7.71833e-60
NZ_CWKV01000003.1\|WP_003721286.1\|23753_24404_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	1.40072e-62
NZ_CWKV01000003.1\|WP_003721304.1\|41104_41827_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.75155e-33
NZ_CWKV01000003.1\|WP_003721303.1\|39937_40753_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_CWKV01000003.1\|WP_003721295.1\|31527_32463_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	2.38027e-153
NZ_CWKV01000003.1\|WP_003721302.1\|38386_39817_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	1.43469e-99
NZ_CWKV01000003.1\|WP_003721292.1\|28746_29793_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NZ_CWKV01000003.1\|WP_003721293.1\|29808_30102_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27

>NZ_CWKV01000003.1|WP_003721295.1|31527_32463_+|ribose-phosphate-pyrophosphokinase
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSSIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>NZ_CWKV01000003.1|WP_003721294.1|30116_31388_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NZ_CWKV01000003.1|WP_003721293.1|29808_30102_+|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NZ_CWKV01000003.1|WP_003721292.1|28746_29793_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPDELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
>NZ_CWKV01000003.1|WP_003721291.1|28099_28750_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNDELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>NZ_CWKV01000003.1|WP_003721290.1|27690_28089_+|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NZ_CWKV01000003.1|WP_003721289.1|27206_27674_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQDKEKLLTEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>NZ_CWKV01000003.1|WP_003721288.1|26576_27179_+|SIS-domain-containing-protein
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVETIAECTGKIVVAGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NZ_CWKV01000003.1|WP_003721287.1|24512_26573_+|BglG-family-transcription-antiterminator
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGRFILEPELTALFSEKETRDPSVEYLPSENERANLILLMLLTSKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPKETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEKVQLMEIRRTLEEAEAMMQIKFTYEQIELLPYLLSVMFLRIRDRRLIDTAFHIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTEKLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDTLYEKFNQEFEALNFIVKEAFDPLAKFIGREIPAGEIFFISLFIGSDMIPQNDIYHKQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDGENVFVVQPFMNDIEKTQLRQHVLQNLFGMGNQLTSIDKIMEVVERNADINDSNAIRDGIIDILSANTATDENKRVKKVYLHDLITEDNIMICEDVKNYQEAIRLASQPLLLQQAITANYVKTMIDNHKFHDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFVIVIAPVDKEQHIEALYQIVHLAENHQILDDLLENVTKEKIMQTINQLVIREDE
>NZ_CWKV01000003.1|WP_003721286.1|23753_24404_+|transaldolase
MHLDSANLDDVKKIQASSIFKGITTNPSILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALAGADFVAPYVNRMSAANIDPFKEISQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYSQMTNKVLAVEAIRVFNEDAVLYEK
>NZ_CWKV01000003.1|WP_009930754.1|33375_33954_+|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTITIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFNILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>NZ_CWKV01000003.1|WP_003721297.1|34061_34742_+|type-1-glutamine-amidotransferase
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPESLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>NZ_CWKV01000003.1|WP_003721298.1|34766_35126_-|Lin0512-family-protein
MEQILFIQTGFGVDVHGQNITKAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>NZ_CWKV01000003.1|WP_003721299.1|35132_35591_-|MarR-family-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTSAGKELENELGDAQRKQMSEIFTNSADTDGMHFTEVMEGYAKNRPGAAFIKDFKE
>NZ_CWKV01000003.1|WP_003721300.1|35972_37808_+|lmo0514-family-class-1-internalin
MKKALKLFLAMICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSARLSITEDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVNPVPPTPEVKPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NZ_CWKV01000003.1|WP_003721301.1|37908_38340_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CWKV01000003.1|WP_003721302.1|38386_39817_-|CapA-family-protein
MKRRTYVIITGLVLIFIAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLNQLIKELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKADEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTIINAESAFTNATKAENKKWRIKSDPAHVAFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIKGGVTEYTYFDPF
>NZ_CWKV01000003.1|WP_003721303.1|39937_40753_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_CWKV01000003.1|WP_003721304.1|41104_41827_+|CRISPR-associated-endoribonuclease-Cas6
MRLKINCDFDSKIISKDFQSKVVSLFKAGIMKSSPERYENLFGGNKHKQYTFSVYLPKPQNKGAEIQLNEANCIINFSTGDAETGIIFYNALMSLRGSKVLFGAGNHITVKNIQIVPEKKIIGKRTILRTLSPVVSRDHNRETFKNWFYSFEDEEFEPTLKRNMLPYLMDAFGEQARYDLEKLKITPISMKKVVVYCHEIHIESSVGIFELEAEAYLQKYLVENGIGTMTGSGFGMIEQF
>NZ_CWKV01000003.1|WP_003721305.1|41842_43531_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MRTEIEVRANDWLINAGLTGFLNIVGKENVRIDGQAIYFTADLLEDFETKYFNFFIQEYKETLSWYKIVSYKETMEQFRIDEFASFDEVALGNLNKYMKDVVKFYLKKANYIKVFPLIDPSANVTKWLEKLNTINLTKKQKWDEVKADIIEEVKQTYTQLDLIIDFCASEKGLQYLGAKNLIYSVINKGWSGVSFLLKQTKFIDPYLDYKTSFLDPVIDYLDTDLSKAKYNCFNCNQPIKNLKLDLSFMNDVGFDTARKTAHVWDFNNDVATCPICRLIYSCVPAGFTYVYGEGMFVNDSYGVEELHRVNERMRNSILRFNKDGINSTNTYRALVESITMEHENNRRYELADIQLVRYENEHYRFNLLSKKMLHIVNDSKGILKSLIRCGYKEGNLNVNLYKEVIQHLMNNENLFTLIHKLIYYKQTSVNGLYYNMGHVSGILDINTKFLKEMEVMTNISQNQLWFVQNCGKEFKEGYVKKKSENKISGITYKLLNSLKVNDKDGFMDTLLNSYSYLSMPIPDVFIKMFSNNEAFKSVGYAFMLGVGGEKTKKEDGGNTDEK

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Crispr_ID: NZ_CWKV01000003_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CWKV01000003_2

48180-50087

Unclear

I-A

Consensus_repeat	Method
GTTTTAACTACTTATTATGAAATGTAAAT	PILER-CR
GTTTTAACTACTTATTATGAAATGTAAAT	CRISPRCasFinder
GTTTTAACTACTTATTATGAAATGTAAAT	CRT

29 spacers

cas2,cas3,cas5,cas7,cas8b2,cas6

The CRISPR arrays of NZ_CWKV01000003_2

>merge|NZ_CWKV01000003|2|48180-50087|PILER-CR,CRISPRCasFinder,CRT
GTTTTAACTACTTATTATGAAATGTAAATAAAGACCTTCGATTTCATTCTCACTTTCCAGTTAATGTTTTAACTACTTATTATGAAATGTAAATTTTTTTGTAGCGGAGGTGTACAATGCCGAAAGTGACGTTTTAACTACTTATTATGAAATGTAAATGCTGGTAAATTTGGCGGAACTAATCGTACTGAAATAGTTTTAACTACTTATTATGAAATGTAAATACATATTAGCCCTTATATAGAAGCCCCGCCCCTACCAGTTTTAACTACTTATTATGAAATGTAAATTATAGTCCCCATATCCATCTGCTATTATCCTCCACGTTTTAACTACTTATTATGAAATGTAAATCGCTTCACGTTGGTTTTTCGTAGCCCAATTGCTAAAGTTTTAACTACTTATTATGAAATGTAAATACGTTGGACAACGAGGTGAGTATGATATGACTCAAATGTTTTAACTACTTATTATGAAATGTAAATGCGGAATGCGAAGTTGTTATATATAACTTATCTCGCGTTTTAACTACTTATTATGAAATGTAAATTCTTAAATGGTGTTTGCACATGTTAAGGGAGTCATGGTTTTAACTACTTATTATGAAATGTAAATGTGCATATCTCCTATATTCATGGCTGTATATGTGTGTTTTAACTACTTATTATGAAATGTAAATCTGGTTACTCAACTGGCGACAGTAATACACCTCAATGTTTTAACTACTTATTATGAAATGTAAATTTTGGATAGGTTGTTTCTGATAAATAGGTTCACGGTTTTAACTACTTATTATGAAATGTAAATAAGTCTACTTGGATTTAGCTCTACACCTGCAACATGAGTTTTAACTACTTATTATGAAATGTAAATAGAAAAAAAACATCTTTCCAATTTGTTGTTTTGCGTTTTAACTACTTATTATGAAATGTAAATAGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTAGTTTTAACTACTTATTATGAAATGTAAATTATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGAGTTTTAACTACTTATTATGAAATGTAAATCTCATAAGGATTTCGAGGCGGGTTAAACGACATGTAGTTTTAACTACTTATTATGAAATGTAAATGCTTTTTTCAACAATTTTATCACCAGATGTCATTAGTTTTAACTACTTATTATGAAATGTAAATTGAGCAGTGTCACCTGTTTCCGTATCTGCTTTTTTCGTTTTAACTACTTATTATGAAATGTAAATAAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGGGTTTTAACTACTTATTATGAAATGTAAATGTCAATAACTAGACGAGCTAACGTTTGTCGCTGTTTGTTTTAACTACTTATTATGAAATGTAAATTGTTATCTCCTGTGATGTAAAATAACCCTTCTATCGTTTTAACTACTTATTATGAAATGTAAATTAATACAAAATATTCATAACTCCTACATCATTATATAGTTTTAACTACTTATTATGAAATGTAAATTTGCAAACCTAACTTATCTTTGTTTTTTTGCTTTTCGTTTTAACTACTTATTATGAAATGTAAATACGTTTGCGGTAGTTTTACCGGGCACGGTCAAATATGTTTTAACTACTTATTATGAAATGTAAATCAAAACAGAGAACGCGTGTTCATTATCGGACATCTTAGTTTTAACTACTTATTATGAAATGTAAATTTTTGAAATATGAGGACTTAGAAAATGAAAAAAATGTTTTAACTACTTATTATGAAATGTAAATAAAAACTATGCAATTAGCAAAGTGATTTTATGTAATTGTTTTAACTACTTATTATGAAATATAAATTAACGAGCCAATTAAACCATCTTCTTCTAGTAATGTTTTAACTACTTATTATGAAATCATAAA

>NZ_CWKV01000003|2|2|48180-50024|PILER-CR
GTTTTAACTACTTATTATGAAATGTAAAT	AAAGACCTTCGATTTCATTCTCACTTTCCAGTTAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTTTGTAGCGGAGGTGTACAATGCCGAAAGTGAC
GTTTTAACTACTTATTATGAAATGTAAAT	GCTGGTAAATTTGGCGGAACTAATCGTACTGAAATA
GTTTTAACTACTTATTATGAAATGTAAAT	ACATATTAGCCCTTATATAGAAGCCCCGCCCCTACCA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAGTCCCCATATCCATCTGCTATTATCCTCCAC
GTTTTAACTACTTATTATGAAATGTAAAT	CGCTTCACGTTGGTTTTTCGTAGCCCAATTGCTAAA
GTTTTAACTACTTATTATGAAATGTAAAT	ACGTTGGACAACGAGGTGAGTATGATATGACTCAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	GCGGAATGCGAAGTTGTTATATATAACTTATCTCGC
GTTTTAACTACTTATTATGAAATGTAAAT	TCTTAAATGGTGTTTGCACATGTTAAGGGAGTCATG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGCATATCTCCTATATTCATGGCTGTATATGTGT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTCTACTTGGATTTAGCTCTACACCTGCAACATGA
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	CTCATAAGGATTTCGAGGCGGGTTAAACGACATGTA
GTTTTAACTACTTATTATGAAATGTAAAT	GCTTTTTTCAACAATTTTATCACCAGATGTCATTA
GTTTTAACTACTTATTATGAAATGTAAAT	TGAGCAGTGTCACCTGTTTCCGTATCTGCTTTTTTC
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCAATAACTAGACGAGCTAACGTTTGTCGCTGTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TGTTATCTCCTGTGATGTAAAATAACCCTTCTATC
GTTTTAACTACTTATTATGAAATGTAAAT	TAATACAAAATATTCATAACTCCTACATCATTATATA
GTTTTAACTACTTATTATGAAATGTAAAT	TTGCAAACCTAACTTATCTTTGTTTTTTTGCTTTTC
GTTTTAACTACTTATTATGAAATGTAAAT	ACGTTTGCGGTAGTTTTACCGGGCACGGTCAAATAT
GTTTTAACTACTTATTATGAAATGTAAAT	CAAAACAGAGAACGCGTGTTCATTATCGGACATCTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	AAAAACTATGCAATTAGCAAAGTGATTTTATGTAATT
GTTTTAACTACTTATTATGAAATATAAAT

>NZ_CWKV01000003|2|2|48180-50087|CRISPRCasFinder
GTTTTAACTACTTATTATGAAATGTAAAT	AAAGACCTTCGATTTCATTCTCACTTTCCAGTTAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTTTGTAGCGGAGGTGTACAATGCCGAAAGTGAC
GTTTTAACTACTTATTATGAAATGTAAAT	GCTGGTAAATTTGGCGGAACTAATCGTACTGAAATA
GTTTTAACTACTTATTATGAAATGTAAAT	ACATATTAGCCCTTATATAGAAGCCCCGCCCCTACCA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAGTCCCCATATCCATCTGCTATTATCCTCCAC
GTTTTAACTACTTATTATGAAATGTAAAT	CGCTTCACGTTGGTTTTTCGTAGCCCAATTGCTAAA
GTTTTAACTACTTATTATGAAATGTAAAT	ACGTTGGACAACGAGGTGAGTATGATATGACTCAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	GCGGAATGCGAAGTTGTTATATATAACTTATCTCGC
GTTTTAACTACTTATTATGAAATGTAAAT	TCTTAAATGGTGTTTGCACATGTTAAGGGAGTCATG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGCATATCTCCTATATTCATGGCTGTATATGTGT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTCTACTTGGATTTAGCTCTACACCTGCAACATGA
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	CTCATAAGGATTTCGAGGCGGGTTAAACGACATGTA
GTTTTAACTACTTATTATGAAATGTAAAT	GCTTTTTTCAACAATTTTATCACCAGATGTCATTA
GTTTTAACTACTTATTATGAAATGTAAAT	TGAGCAGTGTCACCTGTTTCCGTATCTGCTTTTTTC
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCAATAACTAGACGAGCTAACGTTTGTCGCTGTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TGTTATCTCCTGTGATGTAAAATAACCCTTCTATC
GTTTTAACTACTTATTATGAAATGTAAAT	TAATACAAAATATTCATAACTCCTACATCATTATATA
GTTTTAACTACTTATTATGAAATGTAAAT	TTGCAAACCTAACTTATCTTTGTTTTTTTGCTTTTC
GTTTTAACTACTTATTATGAAATGTAAAT	ACGTTTGCGGTAGTTTTACCGGGCACGGTCAAATAT
GTTTTAACTACTTATTATGAAATGTAAAT	CAAAACAGAGAACGCGTGTTCATTATCGGACATCTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	AAAAACTATGCAATTAGCAAAGTGATTTTATGTAATT
GTTTTAACTACTTATTATGAAATATAAAT	TAACGAGCCAATTAAACCATCTTCTTCTAGTAAT
GTTTTAACTACTTATTATGAAATCATAAA

>NZ_CWKV01000003|2|2|48180-50087|CRT
GTTTTAACTACTTATTATGAAATGTAAAT	AAAGACCTTCGATTTCATTCTCACTTTCCAGTTAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTTTGTAGCGGAGGTGTACAATGCCGAAAGTGAC
GTTTTAACTACTTATTATGAAATGTAAAT	GCTGGTAAATTTGGCGGAACTAATCGTACTGAAATA
GTTTTAACTACTTATTATGAAATGTAAAT	ACATATTAGCCCTTATATAGAAGCCCCGCCCCTACCA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAGTCCCCATATCCATCTGCTATTATCCTCCAC
GTTTTAACTACTTATTATGAAATGTAAAT	CGCTTCACGTTGGTTTTTCGTAGCCCAATTGCTAAA
GTTTTAACTACTTATTATGAAATGTAAAT	ACGTTGGACAACGAGGTGAGTATGATATGACTCAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	GCGGAATGCGAAGTTGTTATATATAACTTATCTCGC
GTTTTAACTACTTATTATGAAATGTAAAT	TCTTAAATGGTGTTTGCACATGTTAAGGGAGTCATG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGCATATCTCCTATATTCATGGCTGTATATGTGT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTCTACTTGGATTTAGCTCTACACCTGCAACATGA
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	CTCATAAGGATTTCGAGGCGGGTTAAACGACATGTA
GTTTTAACTACTTATTATGAAATGTAAAT	GCTTTTTTCAACAATTTTATCACCAGATGTCATTA
GTTTTAACTACTTATTATGAAATGTAAAT	TGAGCAGTGTCACCTGTTTCCGTATCTGCTTTTTTC
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCAATAACTAGACGAGCTAACGTTTGTCGCTGTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TGTTATCTCCTGTGATGTAAAATAACCCTTCTATC
GTTTTAACTACTTATTATGAAATGTAAAT	TAATACAAAATATTCATAACTCCTACATCATTATATA
GTTTTAACTACTTATTATGAAATGTAAAT	TTGCAAACCTAACTTATCTTTGTTTTTTTGCTTTTC
GTTTTAACTACTTATTATGAAATGTAAAT	ACGTTTGCGGTAGTTTTACCGGGCACGGTCAAATAT
GTTTTAACTACTTATTATGAAATGTAAAT	CAAAACAGAGAACGCGTGTTCATTATCGGACATCTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATGTAAAT	AAAAACTATGCAATTAGCAAAGTGATTTTATGTAATT
GTTTTAACTACTTATTATGAAATATAAAT	TAACGAGCCAATTAAACCATCTTCTTCTAGTAAT
GTTTTAACTACTTATTATGAAATCATAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CWKV01000003.1\|WP_003721311.1\|50159_50528_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_CWKV01000003.1\|WP_061112174.1\|58039_59371_+\|DUF1254-domain-containing-protein	unknown	unknown	gnl\|CDD\|227659
NZ_CWKV01000003.1\|WP_031668875.1\|45217_47401_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CWKV01000003.1\|WP_061112175.1\|60387_61863_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000003.1\|WP_057171662.1\|50674_52090_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CWKV01000003.1\|WP_003721314.1\|52221_53226_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CWKV01000003.1\|WP_003721300.1\|35972_37808_+\|lmo0514-family-class-1-internalin	unknown	unknown	gnl\|CDD\|380190
NZ_CWKV01000003.1\|WP_003721306.1\|43520_44390_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NZ_CWKV01000003.1\|WP_003721307.1\|44367_45150_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|273860
NZ_CWKV01000003.1\|WP_003721301.1\|37908_38340_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CWKV01000003.1\|WP_003721305.1\|41842_43531_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NZ_CWKV01000003.1\|WP_003721317.1\|55633_56077_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CWKV01000003.1\|WP_003721302.1\|38386_39817_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_CWKV01000003.1\|WP_003721304.1\|41104_41827_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CWKV01000003.1\|WP_003721310.1\|47703_47982_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CWKV01000003.1\|WP_003721303.1\|39937_40753_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CWKV01000003.1\|WP_003721315.1\|53257_54574_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CWKV01000003.1\|WP_031671650.1\|56122_57784_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CWKV01000003.1\|WP_003721320.1\|59417_60158_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CWKV01000003.1\|WP_003721316.1\|54775_55528_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651

Protein	Function_ID	Function_description	E-value
NZ_CWKV01000003.1\|WP_003721311.1\|50159_50528_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	1.10012e-41
NZ_CWKV01000003.1\|WP_061112174.1\|58039_59371_+\|DUF1254-domain-containing-protein	gnl\|CDD\|227659	COG5361, COG5361, Uncharacterized conserved protein [Function unknown].	8.07616e-73
NZ_CWKV01000003.1\|WP_031668875.1\|45217_47401_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	5.29289e-60
NZ_CWKV01000003.1\|WP_057171662.1\|50674_52090_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.87135e-79
NZ_CWKV01000003.1\|WP_003721314.1\|52221_53226_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.07552e-20
NZ_CWKV01000003.1\|WP_003721300.1\|35972_37808_+\|lmo0514-family-class-1-internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.95498e-119
NZ_CWKV01000003.1\|WP_003721306.1\|43520_44390_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	1.33672e-55
NZ_CWKV01000003.1\|WP_003721307.1\|44367_45150_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	1.37797e-23
NZ_CWKV01000003.1\|WP_003721301.1\|37908_38340_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NZ_CWKV01000003.1\|WP_003721305.1\|41842_43531_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	5.75294e-26
NZ_CWKV01000003.1\|WP_003721302.1\|38386_39817_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	1.43469e-99
NZ_CWKV01000003.1\|WP_003721304.1\|41104_41827_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.75155e-33
NZ_CWKV01000003.1\|WP_003721310.1\|47703_47982_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.1393e-30
NZ_CWKV01000003.1\|WP_003721303.1\|39937_40753_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_CWKV01000003.1\|WP_003721315.1\|53257_54574_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CWKV01000003.1\|WP_031671650.1\|56122_57784_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.06019e-147
NZ_CWKV01000003.1\|WP_003721320.1\|59417_60158_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	2.56491e-51
NZ_CWKV01000003.1\|WP_003721316.1\|54775_55528_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	5.24308e-64

>NZ_CWKV01000003.1|WP_003721310.1|47703_47982_+|CRISPR-associated-endonuclease-Cas2
MYVILIYDISIENGGAKVWRNVFKICKKYLTHVQKSVFEGEITPALLVKLRMELDKYIRDDQDSVIVFSSRQQRWLEKEFWGLTDEKTSNFF
>NZ_CWKV01000003.1|WP_031668875.1|45217_47401_+|CRISPR-associated-helicase/endonuclease-Cas3
MHKYLAKSNPEETIQEHTDNLLKNYQRLKKLYPAVEIDWYLLELVCLLHDLGKMNLLFQTKLGNASGKGKEIPHGYLSVAFVPDSKLEEMGYSEDEIKVVYQAIARHHERKYDFSDSEWKKEIIKLEEQWAGFIYSQLGGNAEYSSEVEMLYFYPGSRIFEGNSAADAETFKKYVLLKGLLNRIDFAASGGIDVELENDFLMDSMEVQLAHFKAENPEADWNALQKYMMQHQNENIVVIAETGMGKTEAGLLWLGNNKGFFTLPLRAAINAIYERITKNIVTTNQAERVGLLHSETYSQYLLHEGNAEMDIDEYYTRTRQMSLPITICTLDQLFDFVFRYAGFEHKLATLSYSKVIIDEIQMYSPDLLAYLILGLSYIDKFGGKFCIMTATLPGIVTDLLLENGVDFVQPEEKFVSSRIRHSMEMVHTEIESEFIKPFFNNNRILVICNTISKAKKIYSELKEHFQGEEIHLIHSQFIKRDRSAKEKAIFKDGQKDSTKKCIWVATQVVEASLDIDFDLLFTELSDVNGLFQRMGRCYRNRALDVDTNVYVFDGGAKVCSGIGTFIDKLIFVNSKTILNEHAGVLTEEKKMELVEQVYSTEALSGSEFYNDLIDKLNYVKAFESYLMNKADVRMRFRNINSVSVIPEEVWQDNAEEINSYFVTLRKTSKEISTKEKIIARTNLAEFMVSIPDYLYKKGESVVREINRYESVIEFKCGYSSDVGVFMR
>NZ_CWKV01000003.1|WP_003721307.1|44367_45150_+|type-I-B-CRISPR-associated-protein-Cas5
MLIMKAIRVRLWQDLVNFKKPTSFQLKETYPLPPYSTVIGMVHTLCGFTSYHEMKISIQGKYFSKVNDLATRYEFKNGMTYDASRHQIKVDKYGVSRGVSTVELLVDLELLLHIIPEDPSLVPIIEKAFREPIEFPSLGRREDIATIQKVEVVDVEKRQPKKSTEISDGYNAYVPISLTENNSVHFKSHESSVGRDKLLGTRYLLTEKYERVNHGTEKAPKFFRKWRKKDVIYSSRIFVSKKDVFFFDEDDYLVFIEEEE
>NZ_CWKV01000003.1|WP_003721306.1|43520_44390_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKNKGLAMTIIFQAESANYGESLGNISSLKKISRNNGDQYTYISRQAIRYNLMDQIGEKEAPVKAEGGGDKKVIQFLSEATITDFPELDFFGYLKTEKGSGGQKRSAKVRLSNAISLETFKGDLDFLTNKGQADKLNENMNIAQAEIHKSYYRYTITIDLDQIGIDGEIALDNKEKARRVKKLMDTVAFLYRDIRGRREDLKPLFVIGGVYDVKNPVFQNIVDVADNNIVIKNIKDLLTYEDIKENTRVGIIDGQFANSDEVKVELKAESVPAFFNDIKGKIDAYYESN
>NZ_CWKV01000003.1|WP_003721305.1|41842_43531_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MRTEIEVRANDWLINAGLTGFLNIVGKENVRIDGQAIYFTADLLEDFETKYFNFFIQEYKETLSWYKIVSYKETMEQFRIDEFASFDEVALGNLNKYMKDVVKFYLKKANYIKVFPLIDPSANVTKWLEKLNTINLTKKQKWDEVKADIIEEVKQTYTQLDLIIDFCASEKGLQYLGAKNLIYSVINKGWSGVSFLLKQTKFIDPYLDYKTSFLDPVIDYLDTDLSKAKYNCFNCNQPIKNLKLDLSFMNDVGFDTARKTAHVWDFNNDVATCPICRLIYSCVPAGFTYVYGEGMFVNDSYGVEELHRVNERMRNSILRFNKDGINSTNTYRALVESITMEHENNRRYELADIQLVRYENEHYRFNLLSKKMLHIVNDSKGILKSLIRCGYKEGNLNVNLYKEVIQHLMNNENLFTLIHKLIYYKQTSVNGLYYNMGHVSGILDINTKFLKEMEVMTNISQNQLWFVQNCGKEFKEGYVKKKSENKISGITYKLLNSLKVNDKDGFMDTLLNSYSYLSMPIPDVFIKMFSNNEAFKSVGYAFMLGVGGEKTKKEDGGNTDEK
>NZ_CWKV01000003.1|WP_003721304.1|41104_41827_+|CRISPR-associated-endoribonuclease-Cas6
MRLKINCDFDSKIISKDFQSKVVSLFKAGIMKSSPERYENLFGGNKHKQYTFSVYLPKPQNKGAEIQLNEANCIINFSTGDAETGIIFYNALMSLRGSKVLFGAGNHITVKNIQIVPEKKIIGKRTILRTLSPVVSRDHNRETFKNWFYSFEDEEFEPTLKRNMLPYLMDAFGEQARYDLEKLKITPISMKKVVVYCHEIHIESSVGIFELEAEAYLQKYLVENGIGTMTGSGFGMIEQF
>NZ_CWKV01000003.1|WP_003721303.1|39937_40753_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_CWKV01000003.1|WP_003721302.1|38386_39817_-|CapA-family-protein
MKRRTYVIITGLVLIFIAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLNQLIKELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKADEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTIINAESAFTNATKAENKKWRIKSDPAHVAFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIKGGVTEYTYFDPF
>NZ_CWKV01000003.1|WP_003721301.1|37908_38340_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CWKV01000003.1|WP_003721300.1|35972_37808_+|lmo0514-family-class-1-internalin
MKKALKLFLAMICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSARLSITEDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVNPVPPTPEVKPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NZ_CWKV01000003.1|WP_003721311.1|50159_50528_-|DUF1304-domain-containing-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGMAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVVVLLV
>NZ_CWKV01000003.1|WP_057171662.1|50674_52090_+|multidrug-efflux-MFS-transporter
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGENGWGSATVLVSIIVGGLALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGIPMVMMPAQTNGLNQLPRKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK
>NZ_CWKV01000003.1|WP_003721314.1|52221_53226_+|ROK-family-transcriptional-regulator
MAIPRDLKELNKKNIKSILRQQGAMTKAEIAEVTGLSVVTVNKLIRDLVENEEILEQDNSVATGGRRAVSYEINPNFQQVLVISLQEKWKKITYSFSVYNLLGEPEFVEDMSGEDLDITALKRNTKDIICAFPKISCVVIGVPGIEIGGKLRAMDFPLLLNVQLRETLEAEVNLPVLVETDTNAAILGYKNRPVKEENIVGLYYPERFPPGAGLLMNGEILKGQNGLAGEIKHMPLQVDWDNFDFSVDEIKAHIRKMVLLTMSFYDPETIVLYTNFYFGQKDFMEELKEELKQVYPYAVLPEIVLSRKFTTDYRIGLLAFGIDYLENNMTDWRI
>NZ_CWKV01000003.1|WP_003721315.1|53257_54574_-|6-phospho-beta-glucosidase
MTKGIKIATIGGGSSYTPELIEGFIKRQDELPVRELWLVDVEAGREKLEIVGNLAKRMVKKAGVNMEIHLTLDREEALKDADFVTTQLRVGLLDARVKDERIPNSYGVVGQETNGPGGMFKGLRTIPVILDICKDMERLCPDAWLINFANPAGMVTEAVLRYSNQKKVVGLCNGPIGIERNIAETLGVDVSEIYVEFVGLNHMVFAKTVYHNGKDVTKDVVFKMTEDEAGSSLKNINATGWDKTFLRTLNMIPIDYLRYYWQTKQQLEDQARAYAEHGTRAEVVKKVEAELFELYKQEELAEKPKQLEQRGGAYYSEAACNLINSIYNDKRDIQIVNTRNNGAILDIDPDSAVETNCVITRQGPIPLASGRLPIAINGIIQEIKTFERLTAEAAVTGDYDKALLAMTINPLTPSESVAREMLDELLEAHKEYLPNFFK
>NZ_CWKV01000003.1|WP_003721316.1|54775_55528_+|MurR/RpiR-family-transcriptional-regulator
MLFLDKNLELNDTELDIYNYIVANLDKVVYMRIRDLATEAHVSTTTILRFCRKFGCNGFSEFRVKLQLYLEEQKLAQIDMADETTYIDFLKRTAQPEFKAQIQNAVEILRDRELVLFAGVGSSGVIAEYGAIYFSSLFTLALHIEDPLNHPFYHLSSKLSDKICMIAISVEGENEDIIRYIHQLKAQNCKVISITNSAKSTIARLSDANIAYYINKEMYQEANITSQLPALYTIENIAREIRTQLDKEKM
>NZ_CWKV01000003.1|WP_003721317.1|55633_56077_+|hypothetical-protein
MYSNMKEKVVFTLIMCSLMILCMSSYNIFLENGIGTDSLLIVLKAFVPFLFIGFLLDFFVVGKIVYRLHALLVSEDASKFKKIIMMQLLMVTFMCVLMSTLSLIVNQGEWSHLGILILRNYFVALFLQIFIVSPFVRLISPRIFALL
>NZ_CWKV01000003.1|WP_031671650.1|56122_57784_-|SulP-family-inorganic-anion-transporter
MFKHILLSLNGYKISYLRNDVISGVGVAALTIPVAMGYAQVAGLPPIYGLYASFLPVIAYVIFASSPQLIFGIDATASAITGSIILGTAGLAAGSKEAIALAPILAFFCAIFLVLFSVLKLGRFAKYISAPVLSGFISGLSVSIIMGQIPKIMGLKESGDSFFSSLGIIFGQFFQSNWISFAMGVVTVIIVITCKKVIPKIPMSLVVLVLGTMAAYFFKLDQYNVDIVGKIPVGFPSLALPDFGASSWALAIGGGLVCAIATFAGSLLPSESFAMRNKYTIDDNRELFAYGVSNFVAAFSGCSPASASVSRTAANEQFRGKTQMVSIVAATIIALIVAFLSGLLYYMPQPVLSGIVFAALVGIIDVDVLKGLFKVSRREATVWIVAALGTLLVGVIFGVLLGIFLSFINVVSRSMKTPIAILGVIEGRHGYFDLKRKPEAKPIPNVVIYRYSASLFFGNFNKFADGLKEAVQDDTKLVIFEASAIINIDTTATESMKDLLKWLDDKGIEYYFADLIDHLKTSFRKHDLGYLIDNGYTKKTVEDALDAYYAEHK
>NZ_CWKV01000003.1|WP_061112174.1|58039_59371_+|DUF1254-domain-containing-protein
MATQKNLVDLATKAYIYGFPFIFNTQQIERYVTVGIGGTKQVPFNNFTHASRLAEPSDKFVSVNNDTIYSNAPIDVSAGPVVLSVPDTSGRYYVLQFVDAWSNNFAYVGKRATGTSAGKFLLTPPNWNGDVPADMIEIKFPTNIGIIIGRLACDGEADLPTVRELQEQLKITPLNEGKEVDGFPEYDRSLGKELAFFEQLRVYMAQFPPAERDLVKQESFAPIGLMEKGVSPYSNPSEELKNALIEGAKAGLANIKKATTNFKSENGWGLTQHLFDYNADFFEIGTKKSLDWVIEDREEAYIIRAVSAITALWGNHGYEAVYLMTWTDTDGKALNGKNKYTLELNPIPPVDSFWSITMYDLPEYFLCENPINRYSIGDRTPGIQYNDDGGITIVVSKDEPTDPKERANWLPAPDAEFRPMFRLYNPQQPLVDGSYHFSGFEKK
>NZ_CWKV01000003.1|WP_003721320.1|59417_60158_-|MerR-family-transcriptional-regulator
MQIKELAELTGVSVRTLHHYDKIGLLVPQKDDWNGYRIYSEKDVDKLQQILFFKELDFPLKKIQQILDDPLFDKNVALDMQRHLLIEKKQRIETMLATLDLTIKNEKGEITMTNKEKFTGFDFSSNPYEEEARKLWGDKVVEKANEKVNNMSEKEQLTLKESFDAEFRHLASVRKLTPESEEAQLEIDHFFHYLNDTHGNIYSLEAFASLGEMYVNDERFTKNIDQFGDGLSQFLQEAMTIYAKNK
>NZ_CWKV01000003.1|WP_061112175.1|60387_61863_+|hypothetical-protein
MIRKVKSISMWLWHHVTPQIFAVICVFIITIIALFMPPYIGMADNGDFFRIFSSNGLFVNNTNYDALQFGHFVKEFGIYQYFNENQVAIYSSQSIFIQMALLLNKLFWSTTVFDVRFLGGLQLALLLPAIYLLVAGLTAKMKGWPGYVVAALTVFIFADTAYTAYFNSFFSEGLILIMMLYISAGFLLLYQHKYNDYAMLGLIFVASLILITAKQQNAPIAVVIAVCGILVFFIRKNRAFRISAAATFLVIFLSGVVMYAFIPGEFVTINQYQTMTRGVLLDSENPEKSLEEMGMNSEFALLKGTNFYQKYKMIDLDSKLMEKEFYSNYNFVTVLSYYLENPKQFGKMLDLSAQNSFSIRPFEMGNFEKATGYKFKEKTHFFSAYSDVKEKFAPAKFTFLILWALVFLICYGVSAFKHFREKNIRGTLLFDLIVLLIGSGFAVILVTIVGDGEADLTKHNFLFNVCFDLTMLIGAASLLEVYLKKRGERNA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CWKV01000003_2	2.11\|48859\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	48859-48894	36	NC_003216	Listeria phage A118, complete genome	18563-18598	0	1.0
NZ_CWKV01000003_2	2.11\|48859\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	48859-48894	36	AJ242593	Bacteriophage A118 complete genome	18563-18598	0	1.0
NZ_CWKV01000003_2	2.15\|49116\|34\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49116-49149	34	NC_003216	Listeria phage A118, complete genome	19172-19205	0	1.0
NZ_CWKV01000003_2	2.15\|49116\|34\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49116-49149	34	AJ242593	Bacteriophage A118 complete genome	19172-19205	0	1.0
NZ_CWKV01000003_2	2.6\|48534\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	48534-48569	36	NZ_CP011399	Listeria monocytogenes strain CFSAN008100 plasmid pCFSAN008100, complete sequence	60125-60160	1	0.972
NZ_CWKV01000003_2	2.6\|48534\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	48534-48569	36	NC_009812	Listeria phage B025, complete genome	27503-27538	1	0.972
NZ_CWKV01000003_2	2.25\|49764\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49764-49799	36	NC_021539	Listeria phage LP-030-2, complete genome	14044-14079	1	0.972
NZ_CWKV01000003_2	2.25\|49764\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49764-49799	36	AJ312240	Bacteriophage PSA complete genome	14022-14057	1	0.972
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	KY705255	Streptococcus phage P0095, complete genome	33666-33702	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	KY705251	Streptococcus phage P0091, complete genome	32778-32814	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	KX879643	Streptococcus phage CHPC1151, complete genome	31697-31733	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	MK202161	Streptococcus phage CHPC1282, complete genome	32484-32520	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	KY705252	Streptococcus phage P0092, complete genome	31845-31881	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	MH937506	Streptococcus phage CHPC1148, complete genome	35552-35588	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	KY705253	Streptococcus phage P0093, complete genome	32631-32667	1	0.973
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	KY705254	Streptococcus phage P0094, complete genome	31034-31070	1	0.973
NZ_CWKV01000003_2	2.6\|48534\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	48534-48569	36	KJ094023	Listeria phage LP-101, complete genome	27001-27036	2	0.944
NZ_CWKV01000003_2	2.17\|49244\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49244-49279	36	KP399678	Listeria phage vB_LmoS_293, complete genome	1049-1084	2	0.944
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	MN689509	Lactococcus phage CHPC1175, complete genome	29544-29580	2	0.946
NZ_CWKV01000003_2	2.26\|49829\|37\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49829-49865	37	MK448735	Streptococcus phage Javan349, complete genome	11483-11519	2	0.946
NZ_CWKV01000003_2	2.1\|48209\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	48209-48244	36	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	228347-228382	3	0.917
NZ_CWKV01000003_2	2.16\|49179\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49179-49214	36	MH341453	Listeria phage PSU-VKH-LP041, complete genome	41996-42031	3	0.917
NZ_CWKV01000003_2	2.16\|49179\|36\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49179-49214	36	KJ094023	Listeria phage LP-101, complete genome	32760-32795	5	0.861
NZ_CWKV01000003_2	2.14\|49053\|34\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49053-49086	34	NC_022111	Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence	1764851-1764884	6	0.824
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	MN694189	Marine virus AFVG_250M578, complete genome	47879-47913	6	0.829
NZ_CWKV01000003_2	2.14\|49053\|34\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49053-49086	34	NZ_CP038863	Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence	39302-39335	9	0.735
NZ_CWKV01000003_2	2.18\|49309\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49309-49343	35	NC_014533	Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence	491525-491559	9	0.743
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	MK448625	Streptococcus satellite phage Javan738, complete genome	5960-5994	9	0.743
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	MK448449	Streptococcus satellite phage Javan356, complete genome	4490-4524	9	0.743
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	MK448636	Streptococcus satellite phage Javan749, complete genome	6112-6146	9	0.743
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	NZ_CP045037	Lactobacillus mali strain LM596 plasmid unnamed2, complete sequence	34734-34768	9	0.743
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	NZ_CP018177	Lactobacillus hordei strain TMW 1.1822 plasmid pL11822-1, complete sequence	11325-11359	9	0.743
NZ_CWKV01000003_2	2.27\|49895\|35\|NZ_CWKV01000003\|PILER-CR,CRISPRCasFinder,CRT	49895-49929	35	NZ_CP018181	Lactobacillus nagelii strain TMW 1.1827 plasmid pL11827-1, complete sequence	63608-63642	9	0.743

1. spacer 2.11|48859|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

2. spacer 2.11|48859|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

3. spacer 2.15|49116|34|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

4. spacer 2.15|49116|34|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

5. spacer 2.6|48534|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011399 (Listeria monocytogenes strain CFSAN008100 plasmid pCFSAN008100, complete sequence) position: , mismatch: 1, identity: 0.972

cgcttcacgttggtttttcgtagcccaattgctaaa	CRISPR spacer
cgcttcacgttgatttttcgtagcccaattgctaaa	Protospacer
************.***********************

6. spacer 2.6|48534|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 1, identity: 0.972

cgcttcacgttggtttttcgtagcccaattgctaaa	CRISPR spacer
cgcttcacgttgatttttcgtagcccaattgctaaa	Protospacer
************.***********************

7. spacer 2.25|49764|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NC_021539 (Listeria phage LP-030-2, complete genome) position: , mismatch: 1, identity: 0.972

acgtttgcggtagttttaccgggcacggtcaaatat	CRISPR spacer
acgttcgcggtagttttaccgggcacggtcaaatat	Protospacer
*****.******************************

8. spacer 2.25|49764|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to AJ312240 (Bacteriophage PSA complete genome) position: , mismatch: 1, identity: 0.972

acgtttgcggtagttttaccgggcacggtcaaatat	CRISPR spacer
acgttcgcggtagttttaccgggcacggtcaaatat	Protospacer
*****.******************************

9. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KY705255 (Streptococcus phage P0095, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

10. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KY705251 (Streptococcus phage P0091, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

11. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KX879643 (Streptococcus phage CHPC1151, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

12. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MK202161 (Streptococcus phage CHPC1282, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

13. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KY705252 (Streptococcus phage P0092, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

14. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MH937506 (Streptococcus phage CHPC1148, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

15. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KY705253 (Streptococcus phage P0093, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

16. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KY705254 (Streptococcus phage P0094, complete genome) position: , mismatch: 1, identity: 0.973

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgagtgttcattatcggacatctta	Protospacer
************** **********************

17. spacer 2.6|48534|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 2, identity: 0.944

cgcttcacgttggtttttcgtagcccaattgctaaa	CRISPR spacer
cgcttcacgttgattttttgtagcccaattgctaaa	Protospacer
************.*****.*****************

18. spacer 2.17|49244|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KP399678 (Listeria phage vB_LmoS_293, complete genome) position: , mismatch: 2, identity: 0.944

ctcataaggatttcgaggcgggttaaacgacatgta	CRISPR spacer
ctcataaggattgcgaggcgggttaaatgacatgta	Protospacer
************ **************.********

19. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MN689509 (Lactococcus phage CHPC1175, complete genome) position: , mismatch: 2, identity: 0.946

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaaccgagaacgtgtgttcattatcggacatctta	Protospacer
****** *******.**********************

20. spacer 2.26|49829|37|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MK448735 (Streptococcus phage Javan349, complete genome) position: , mismatch: 2, identity: 0.946

caaaacagagaacgcgtgttcattatcggacatctta	CRISPR spacer
caaaacagagaacgggtgttcattgtcggacatctta	Protospacer
************** *********.************

21. spacer 2.1|48209|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 3, identity: 0.917

aaagaccttcgatttcattctcactttccagttaat	CRISPR spacer
gaaaaccttcgatttcattcttactttccagttaat	Protospacer
.**.*****************.**************

22. spacer 2.16|49179|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 3, identity: 0.917

tataaaatattgcccaatgtgcggaaggagtttgga	CRISPR spacer
tataaaatattgtccaatgtgtggaaggagtttggg	Protospacer
************.********.*************.

23. spacer 2.16|49179|36|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 5, identity: 0.861

tataaaatattgcccaatgtgcggaaggagtttgga	CRISPR spacer
cattgaattttgcccaatgtgcggaaggagcttgga	Protospacer
.** .*** *********************.*****

24. spacer 2.14|49053|34|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NC_022111 (Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence) position: , mismatch: 6, identity: 0.824

agaaaaaaaacatctttccaatttgttgttttgc	CRISPR spacer
agcaaaaaaacatctttcctatttgttttatcac	Protospacer
** **************** ******* * *..*

25. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MN694189 (Marine virus AFVG_250M578, complete genome) position: , mismatch: 6, identity: 0.829

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
taataaaaaatgagggcttagaaaatgaaaaaatt	Protospacer
*  *.*** ******.***************** *

26. spacer 2.14|49053|34|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP038863 (Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

agaaaaaaaacatctttccaatttgttgttttgc-----	CRISPR spacer
aagaaaaaaacatatttccaatt-----ttttccaaaaa	Protospacer
*..********** *********     **** *

27. spacer 2.18|49309|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NC_014533 (Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence) position: , mismatch: 9, identity: 0.743

gcttttttcaacaattttatcaccagatgtcatta	CRISPR spacer
agttttttcaacaattttatgaacagataattttt	Protospacer
. ****************** * *****. . **

28. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MK448625 (Streptococcus satellite phage Javan738, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtatgaactatgaggacttagaaagtgaagacctg	Protospacer
 * **** ****************.****.*

29. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MK448449 (Streptococcus satellite phage Javan356, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtatgaactatgaggacttagaaagtgaagacctg	Protospacer
 * **** ****************.****.*

30. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to MK448636 (Streptococcus satellite phage Javan749, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtctgaactatgaggacttagaaagtgaagacctg	Protospacer
 *.**** ****************.****.*

31. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045037 (Lactobacillus mali strain LM596 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

32. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018177 (Lactobacillus hordei strain TMW 1.1822 plasmid pL11822-1, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

33. spacer 2.27|49895|35|NZ_CWKV01000003|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018181 (Lactobacillus nagelii strain TMW 1.1827 plasmid pL11827-1, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage