CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_APIC01000017	Listeria monocytogenes SHL002 contig17, whole genome shotgun sequence	0 crisprs	cas3	0	0	0	0
NZ_APIC01000004	Listeria monocytogenes SHL002 contig4, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000016	Listeria monocytogenes SHL002 contig16, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000018	Listeria monocytogenes SHL002 contig18, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000012	Listeria monocytogenes SHL002 contig12, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000005	Listeria monocytogenes SHL002 contig5, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000015	Listeria monocytogenes SHL002 contig15, whole genome shotgun sequence	0 crisprs	NA	0	0	1	1
NZ_APIC01000021	Listeria monocytogenes SHL002 contig21, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000014	Listeria monocytogenes SHL002 contig14, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_APIC01000006	Listeria monocytogenes SHL002 contig6, whole genome shotgun sequence	0 crisprs	DinG	0	0	0	0
NZ_APIC01000011	Listeria monocytogenes SHL002 contig11, whole genome shotgun sequence	0 crisprs	casR,WYL	0	0	0	0
NZ_APIC01000020	Listeria monocytogenes SHL002 contig20, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000022	Listeria monocytogenes SHL002 contig22, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000010	Listeria monocytogenes SHL002 contig10, whole genome shotgun sequence	1 crisprs	NA	0	0	0	0
NZ_APIC01000003	Listeria monocytogenes SHL002 contig3, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_APIC01000008	Listeria monocytogenes SHL002 contig8, whole genome shotgun sequence	0 crisprs	WYL,csa3	0	0	1	0
NZ_APIC01000019	Listeria monocytogenes SHL002 contig19, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_APIC01000007	Listeria monocytogenes SHL002 contig7, whole genome shotgun sequence	1 crisprs	RT,cas6,cas8b2,cas7,cas5,cas3,cas2	2	14	1	1
NZ_APIC01000013	Listeria monocytogenes SHL002 contig13, whole genome shotgun sequence	0 crisprs	csa3,cas5	0	0	1	0
NZ_APIC01000002	Listeria monocytogenes SHL002 contig2, whole genome shotgun sequence	0 crisprs	DEDDh,cas3	0	0	2	0
NZ_APIC01000001	Listeria monocytogenes SHL002 contig1, whole genome shotgun sequence	2 crisprs	DinG,csa3,cas9,cas1,cas2,csn2	2	9	1	0
NZ_APIC01000009	Listeria monocytogenes SHL002 contig9, whole genome shotgun sequence	0 crisprs	NA	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

123417 : 130839

Hokovirus(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012681222.1\|123417_124974_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.3e-17	28.1
WP_003724635.1\|125102_125507_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_003724634.1\|125566_125875_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_003727000.1\|125887_126712_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	9.7e-68	52.6
WP_003721509.1\|126723_128214_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
WP_003727001.1\|128422_129436_-	glycosyltransferase	A0A1V0SAH6	Catovirus	1.8e-10	31.2
WP_003727002.1\|129450_130434_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	2.0e-11	33.8
WP_003730941.1\|130455_130839_-	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_APIC01000010

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CRISPR-Cas detection and classification

Crispr_ID: NZ_APIC01000010_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_APIC01000010_1

3107-3691

Orphan

Consensus_repeat	Method
CATATNAGTTACTGAACTNGTATCAAAATTACTTACATC	CRT

7 spacers

The CRISPR arrays of NZ_APIC01000010_1

>merge|NZ_APIC01000010|1|3107-3691|CRT
CATGTTAGTCACTGAACTGGTATCAAAGGTACTTAAATCAAGCTTCTCCAGTTTTTCATTATCAGAAAACATGGCAGCCATATTAGTTACTGAACTCGTATCAAAATTACTTACATCTAACGCTTCAAGACTAGTACAACCAGCAAACATGGCACGCATATCAGTTACTAAGCTCGTATTAAAATTACTTACATCCAACTTCTCAAGGGCGCTACAATTTCTAAACATTTGAACCATTGCAGTAGCGGAACTGGTATCGAAATTACTTACATCTAGTTTCTTCAGTTTTTCACAGCCATTAAACACTCTATACATATCAGTTACTGAACTCGTATCAAAATTACTTACATCCAGCTCTTCAAGACTAGTACAATCTTCAAACATGGCATACATATTAGTTACTGAACCGGTATCAAGGTTGCTTACATCCAGCACCTCAAGGTTTCTATTATCATAAAACATGTAAGACATATTAGTTACTGAACTCGTATCAAAATGACTTACATCCAGTTCCTCAAGTGCCCTACAGCTGTTAAACATATCCCACATAGTAGTTACCGCACTAGTATCAAGACCACTCAAATC

>NZ_APIC01000010|1|1|3107-3691|CRT
CATGTTAGTCACTGAACTGGTATCAAAGGTACTTAAATC	AAGCTTCTCCAGTTTTTCATTATCAGAAAACATGGCAGC
CATATTAGTTACTGAACTCGTATCAAAATTACTTACATC	TAACGCTTCAAGACTAGTACAACCAGCAAACATGGCACG
CATATCAGTTACTAAGCTCGTATTAAAATTACTTACATC	CAACTTCTCAAGGGCGCTACAATTTCTAAACATTTGAAC
CATTGCAGTAGCGGAACTGGTATCGAAATTACTTACATC	TAGTTTCTTCAGTTTTTCACAGCCATTAAACACTCTATA
CATATCAGTTACTGAACTCGTATCAAAATTACTTACATC	CAGCTCTTCAAGACTAGTACAATCTTCAAACATGGCATA
CATATTAGTTACTGAACCGGTATCAAGGTTGCTTACATC	CAGCACCTCAAGGTTTCTATTATCATAAAACATGTAAGA
CATATTAGTTACTGAACTCGTATCAAAATGACTTACATC	CAGTTCCTCAAGTGCCCTACAGCTGTTAAACATATCCCA
CATAGTAGTTACCGCACTAGTATCAAGACCACTCAAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_APIC01000010.1\|WP_014929914.1\|4483_6565_-\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NZ_APIC01000010.1\|WP_039379048.1\|386_2144_-\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NZ_APIC01000010.1\|WP_003731690.1\|16920_19080_+\|transglutaminase	unknown	unknown	gnl\|CDD\|376628
NZ_APIC01000010.1\|WP_003721242.1\|14823_15771_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_APIC01000010.1\|WP_003728093.1\|10545_11646_-\|DUF917-domain-containing-protein	unknown	unknown	gnl\|CDD\|226065
NZ_APIC01000010.1\|WP_003731687.1\|9002_10553_-\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_APIC01000010.1\|WP_003725188.1\|13063_14635_-\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_APIC01000010.1\|WP_003731689.1\|15775_16924_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_APIC01000010.1\|WP_003725185.1\|19196_19952_+\|DUF4866-domain-containing-protein	unknown	unknown	gnl\|CDD\|379782
NZ_APIC01000010.1\|WP_023553878.1\|6828_8367_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NZ_APIC01000010.1\|WP_003728992.1\|11646_12930_-\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NZ_APIC01000010.1\|WP_039378558.1\|0_321_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_APIC01000010.1\|WP_003728093.1\|10545_11646_-\|DUF917-domain-containing-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NZ_APIC01000010.1\|WP_003731687.1\|9002_10553_-\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.16889e-106
NZ_APIC01000010.1\|WP_003725188.1\|13063_14635_-\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.84415e-59
NZ_APIC01000010.1\|WP_003731689.1\|15775_16924_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.71221e-52
NZ_APIC01000010.1\|WP_039379048.1\|386_2144_-\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	1.72931e-27
NZ_APIC01000010.1\|WP_014929914.1\|4483_6565_-\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	3.34186e-29
NZ_APIC01000010.1\|WP_023553878.1\|6828_8367_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	4.85465e-19
NZ_APIC01000010.1\|WP_003728992.1\|11646_12930_-\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	1.15029e-95
NZ_APIC01000010.1\|WP_003731690.1\|16920_19080_+\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	4.24069e-28
NZ_APIC01000010.1\|WP_003721242.1\|14823_15771_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.47241e-102
NZ_APIC01000010.1\|WP_003725185.1\|19196_19952_+\|DUF4866-domain-containing-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	2.72643e-122

>NZ_APIC01000010.1|WP_039379048.1|386_2144_-|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFIAFGSANVSIAQERDTTNKLPEEELGSLDTSNIIAEEVAQEKPAEVEQLEEIPITDELMQNPDVLEQPVADSDDTDLTVVSSGDFWTIYRNTVNNEYSLCMFGNVPSSRPTAWNSYLKSIKHIEIEEATLTGSFEAYFRGTVFTVLESVRIEQCNLSGVTSFDMAFYNSGIEKVIIRDNDYPTAPSLLATTYMFSLCRNLSELDLSGLDTSAVTNIYGMFQNCIRLEELDLSNFDTSSVTNMYSTFSGCRSLEKLDVSNFDTSSVTTMWAMFFECSSLEELDLSNFDTSSVTTMSYMFQLCPALKSLYLDNFTDAAIMTGMFGGTTSLTYLFVSHNLSTFNNLENTSWYDEKNWVQFSNLSQLQTYHRQQSEPTGYRKGAFLSLTMDAMGGQFEDAEEQKVQNKVSGEYWDEIVPVKEGHYFDGWYLNQDCTNKFDFSLPADASITIYAKWIENYTVIIPASISLNETSELKVEGINRGDKNLSVGLNRTAMSVSESNKLTLANTADTTVQCLAPLSWDGSETNPEKAILTLAPGSEITEGDAVMAIEAPENIQAGKYTGNLVFSIKYE
>NZ_APIC01000010.1|WP_039378558.1|0_321_-|hypothetical-protein
MKKKRVVIISLLLLLVSVIGISSYFLFKDKINLLDVDHSAVDWNGKKQKDTSGEENTIAIPGFEKVTLYANETTQAVNFHNPEINDCYFKISLIHPDGSVLWISDLI
>NZ_APIC01000010.1|WP_014929914.1|4483_6565_-|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFIALGNANVSIAQERDTTNKLPEEELGSLDTSNLIAEEVAQEKPAEVENLEEIPTTDELMQNPEVREQPVADSDDPDLTAVSSGDYWTIYYNSANDEYSLRMFGNVPSSKPSAWNSYLKYIKHIEIEEATLTGDFSSYFRSNVFTVLESVRIERSNLSGVTSFARAFEGDSESESPLEKVIIRDNYYPETPSLTNISRMFTLCRKLSELDVSGLNTSSVTKMDTIFSNANSLKELDVSHFDTSSVTDMSSMFAACNSLEELDVSNFDTSSVTNMKYMLSGLHLKKLDVSNFDTSSVTNMYGMFAYCYNLEELDVSNFDTSSVNNMLHMFYVCNNLEELDLSNFDTSSVTNMFAMFAYCTSLKEIDVSNFDTSSVTTMSAMFFECSSLEALDLSNFDTSSVTTMASMFENSTALKSLYLDNFTDAASMTDMFKGTTSLTYLFVSHNLSTFNRLENTSWYDEKNWVQFSNLSQLQTYHRKQSEPTGYRKGAFLSLTMDAMGGEFEDAEEQKVQNKVSGEYWEEIVPVKEDYYFDGWYLDQNFTNKFDFSLPAAVSTTIYAKWVENYTVIIPASISLNEATELKVEGINRGSKALSVGLNRLATSVSESNELTLANTADTTVQCSAPLSWDGSENNPEKAILTLAPGSEITEGDAVMAIEAPENIQAGKYTGNLVFSINYE
>NZ_APIC01000010.1|WP_023553878.1|6828_8367_-|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLSSFPNLQALAKKVHVSYSGIKKEIKELNEELRERNLYISTGNQVEITGDEFSLRIFYAFLFLVAYSGDRWPFSFVRYDEITDLLESCPKEIYRANSIDKAMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQVPNRSYKEMTYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASEQVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINKFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMDPLKPFEERLTSDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIIYVNTRWLESDYVKINDNLAKIARKKFIANKKN
>NZ_APIC01000010.1|WP_003731687.1|9002_10553_-|hydantoinase/oxoprolinase-family-protein
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGRAEIGNPELVAYIPTDFAEKAYKKIAEMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NZ_APIC01000010.1|WP_003728093.1|10545_11646_-|DUF917-domain-containing-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTGSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NZ_APIC01000010.1|WP_003728992.1|11646_12930_-|cytosine-permease
MTEKKSVEQTQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVLFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPVLLFVCIYGLVVSLNDGGLAIVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMITVGAVLALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAVAGGLGTILAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVSGVNWLGVSSWLVGAVIAGIPVILTFFPELPQLPNQPLIGIILSLAVYLIGAKVLSGKTNNVENLEGK
>NZ_APIC01000010.1|WP_003725188.1|13063_14635_-|PucR-family-transcriptional-regulator
MKLPSLKEAKVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIRDDVEAQCRTIERLHKVGEVALILYYVGIFVPKMDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHTSLVLTDNSFQVINSITWPRTRHWDFERIIEASKQIGEHELVQLTLDERDFYTARKPIFQDGMQAMHLFMMKEKGVLTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRDNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVAQRDRTHTANEFAMMMKEHGIDLKITVCQGMEQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKPLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRILGGNNNNK
>NZ_APIC01000010.1|WP_003721242.1|14823_15771_+|MoxR-family-ATPase
MSIEPSIKIEEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTQQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NZ_APIC01000010.1|WP_003731689.1|15775_16924_+|DUF58-domain-containing-protein
MLKKRLLLAFRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRRFVKNTYHDGDLIDMQVSFTRKSRYPVGYLLFQQKIPASFGNVSARQQVVYPLFKKHFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPDVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEDNGEIRVTLLGDQTSKFAPAKGTSKLQDISTAFAEIAPVDNLTLQESLDSNLHSGEKILLFTPCIDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEPASLLSRWEREAK
>NZ_APIC01000010.1|WP_003731690.1|16920_19080_+|transglutaminase
MKRYLTLVMLFILSVLLISEWIYPFAELTELSKANWIILFITLSLGSFFLRLKYYWTIPLHIVMIIFVSGIYYAKGGILAGNWFVSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRVMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIAAPNRISADSLKRNGLFYHIFVILLLAVFVFSSLMLPKKAPIFPDPVPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTARAEKGHYWRVESKTVYTGTGWANANSADVISFSSGDNFPIQLTEQTTGATNTAEISFASSNDYMPYPYGTQTVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNAFVSQYTQTPKDLPDRVTKLANKVTKDADSIYDKTKAIERYLSASGTFTYSTEDAKETPRGADYVDQFLFETQIGYCDNFSTSMVVMLRSLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTADKTPEQDNGSSSTGETPKKEEPKTETAASNFEIPSWVWWIPAGLVVTLLALAIIFRRRIRRYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSTRVDAELTTTEFSRLTKMYEAQIYSNNLTEKVITAEETQLVQQVIARLTK
>NZ_APIC01000010.1|WP_003725185.1|19196_19952_+|DUF4866-domain-containing-protein
MTTIFPKEQNVAPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIVHSYEPDFSISTKRINKKRGILVLYSLPDTLKLGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_APIC01000008

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

74689 : 82531

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003725407.1\|74689_75661_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
WP_039378931.1\|75668_76637_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.4e-68	43.9
WP_003722606.1\|76638_77514_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.9e-08	29.7
WP_003731211.1\|77621_79352_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	2.8e-173	53.0
WP_003741152.1\|79393_80455_-	galactose mutarotase	NA	NA	NA	NA
WP_003731209.1\|80471_81455_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	1.5e-51	38.1
WP_003722610.1\|81571_82531_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_APIC01000014

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 35716

Listeria_phage(96.15%)

portal,holin,tail,capsid,terminase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039379191.1\|0_219_-\|holin	holin	R4IDW2	Listeria_phage	8.1e-30	94.5
WP_003722523.1\|231_597_-	hypothetical protein	Q9T1A0	Listeria_phage	7.4e-12	100.0
WP_003722524.1\|624_783_-	hypothetical protein	Q9T1A1	Listeria_phage	6.0e-19	100.0
WP_003722525.1\|787_1105_-	hypothetical protein	Q9T1A2	Listeria_phage	6.2e-55	100.0
WP_039379194.1\|1116_2190_-\|plate	phage baseplate upper protein	Q9T1A3	Listeria_phage	3.0e-186	93.6
WP_003722527.1\|2189_3218_-	hypothetical protein	Q9T1A4	Listeria_phage	4.6e-192	100.0
WP_039379196.1\|3218_4244_-\|tail	phage tail protein	Q9T1A5	Listeria_phage	5.2e-196	97.1
WP_039379198.1\|4252_5071_-\|tail	phage tail family protein	Q9T1A6	Listeria_phage	5.0e-149	93.0
WP_039379201.1\|5072_10466_-	tape measure protein	Q9T1A7	Listeria_phage	0.0e+00	85.2
WP_003731740.1\|10476_11079_-	bacteriophage Gp15 family protein	A8ASK5	Listeria_phage	2.0e-107	98.0
WP_003731739.1\|11084_11507_-\|tail	phage tail assembly chaperone	Q9T1A9	Listeria_phage	3.4e-69	98.6
WP_039379205.1\|11558_11891_-	Ig domain-containing protein	Q9T1B0	Listeria_phage	3.4e-40	85.5
WP_039379208.1\|11820_12255_-	hypothetical protein	Q9T1B1	Listeria_phage	4.3e-75	97.2
WP_039379212.1\|12257_12665_-	hypothetical protein	A8ASK1	Listeria_phage	1.3e-65	97.8
WP_039379215.1\|12664_13003_-\|capsid	minor capsid protein	A0A059T7W4	Listeria_phage	3.0e-55	94.6
WP_039379217.1\|13002_13365_-	hypothetical protein	Q9T1B4	Listeria_phage	3.0e-61	95.8
WP_039379219.1\|13364_13760_-	hypothetical protein	A0A0B5D0F6	Listeria_phage	1.5e-63	95.4
WP_077916370.1\|13761_13920_-	hypothetical protein	Q9T1B6	Listeria_phage	5.6e-17	92.3
WP_039379221.1\|13919_14819_-\|capsid	phage major capsid protein	Q9T1B7	Listeria_phage	3.8e-166	99.0
WP_039379222.1\|14842_15412_-	phage scaffolding protein	Q9T1B8	Listeria_phage	6.0e-93	97.9
WP_039379225.1\|15490_16630_-\|capsid	phage minor capsid protein	Q9T1B9	Listeria_phage	5.3e-197	94.7
WP_039379228.1\|16635_18126_-\|portal	phage portal protein	Q9T1C0	Listeria_phage	9.7e-276	96.4
WP_039379232.1\|18138_19470_-\|terminase	PBSX family phage terminase large subunit	Q9T1C1	Listeria_phage	3.8e-263	99.5
WP_014601088.1\|19438_19981_-\|terminase	terminase small subunit	Q9T1C2	Listeria_phage	2.6e-93	100.0
WP_003722546.1\|20064_20775_-	hypothetical protein	Q9T152	Listeria_phage	1.4e-123	99.6
WP_003731727.1\|21141_21576_-	hypothetical protein	A8AU03	Listeria_phage	2.5e-70	91.0
WP_031659968.1\|21718_22123_-	endodeoxyribonuclease	A8AU00	Listeria_phage	2.2e-65	91.0
WP_115904973.1\|22088_22229_-	BH0509 family protein	A8ATZ9	Listeria_phage	9.4e-16	89.1
WP_039379240.1\|22225_22531_-	transcriptional regulator	A8ATZ8	Listeria_phage	9.5e-45	97.0
WP_039379243.1\|22562_23045_-	single-stranded DNA-binding protein	A8ASP5	Listeria_phage	7.9e-78	92.5
WP_038409823.1\|23044_23446_-	hypothetical protein	A8ATZ6	Listeria_phage	6.0e-63	92.5
WP_039379248.1\|23442_23802_-	hypothetical protein	A0A059T801	Listeria_phage	2.9e-45	91.0
WP_039379251.1\|23817_24165_-	hypothetical protein	A0A059T8V4	Listeria_phage	1.2e-56	87.8
WP_039379258.1\|24350_24623_-	hypothetical protein	A8ATE2	Listeria_phage	5.0e-45	95.6
WP_039379261.1\|24766_24973_-	hypothetical protein	NA	NA	NA	NA
WP_014929526.1\|24988_25135_-	hypothetical protein	A8ATZ0	Listeria_phage	1.7e-20	100.0
WP_039379265.1\|25131_25722_-	DUF1642 domain-containing protein	A8ATD8	Listeria_phage	3.8e-50	58.5
WP_077916372.1\|25973_26336_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_003731842.1\|26406_26574_-	hypothetical protein	A8ASN5	Listeria_phage	9.2e-18	80.0
WP_039379305.1\|26586_27117_-	hypothetical protein	A0A059T5F9	Listeria_phage	4.8e-92	91.5
WP_039379273.1\|27164_28076_-	DnaD domain-containing protein	A0A0B5D175	Listeria_phage	1.7e-134	88.2
WP_039379276.1\|28113_29025_-	recombinase RecT	A0A2H4JA23	uncultured_Caudovirales_phage	1.2e-37	40.5
WP_031670337.1\|29017_30529_-	ATPase	A0A2I7SC81	Paenibacillus_phage	7.5e-74	35.6
WP_031643418.1\|30760_30949_-	hypothetical protein	A0A059T7X9	Listeria_phage	3.8e-28	98.4
WP_039379282.1\|31051_31258_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_039379284.1\|31247_31778_-	hypothetical protein	A0A0B5D173	Listeria_phage	3.0e-78	88.4
WP_039379287.1\|31897_32671_-	phage antirepressor KilAC domain-containing protein	A8ATY0	Listeria_phage	6.0e-136	96.1
WP_003733684.1\|32734_32932_+	hypothetical protein	Q9T179	Listeria_phage	4.0e-20	96.0
WP_003722567.1\|32933_33215_-	hypothetical protein	A8ATX8	Listeria_phage	1.8e-37	95.7
WP_039379292.1\|33240_33525_-	hypothetical protein	A0A0B5D168	Listeria_phage	7.7e-41	86.2
WP_003731220.1\|33528_33780_-	helix-turn-helix transcriptional regulator	A8ATX6	Listeria_phage	7.6e-40	100.0
WP_026750223.1\|33928_34237_+	helix-turn-helix transcriptional regulator	A8ATX5	Listeria_phage	2.7e-47	99.0
WP_012951966.1\|34267_34759_+	hypothetical protein	A8ATX4	Listeria_phage	2.9e-91	99.4
WP_003727739.1\|34781_35000_+	zinc-ribbon domain-containing protein	A0A059T6E3	Listeria_phage	5.4e-34	100.0
WP_039379299.1\|35014_35716_+	hypothetical protein	A0A0B5D125	Listeria_phage	3.9e-86	89.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_APIC01000007

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_APIC01000007_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_APIC01000007_1

49519-50846

Unclear

I-A

Consensus_repeat	Method
GTTTTAACTACTTATTATGAAATGTAAATATTA	PILER-CR
GTTTTAACTACTTATTATGAAATGTAAAT	CRISPRCasFinder
GTTTTAANNNCTACTTATTATGAAATGTAAAT	CRT
GTTTTAACTACTTATTATGAAATGTAAAT	PILER-CR

20 spacers

cas2,cas3,cas5,cas7,cas8b2,cas6

The CRISPR arrays of NZ_APIC01000007_1

>merge|NZ_APIC01000007|1|49519-50846|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTTTAACTACTTATTATGAAATGTAAATCAATGCTTAAACCGAGAGCATCAAATTGTTCCCATGCGTTTTAACTACTTATTATGAAATGTAAATATTACAGTACAAGCAAGGGTTATTGAGTTAAATATTGTTTTAACTACTTATTATGAAATGTAAATATTAATGATAAGAGCGGAAAGAAAACTTTCAAGGGGTTTTAACTACTTATTATGAAATGTAAATTCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAGGTTTTAACTACTACTTATTATGAAATGTAAATTCGTTTATGACCTTATGAAAGAGTTAACACCTCGACGTTTTAACTACTTATTATGAAATGTAAATCTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTGGTTTTAACTACTTATTATGAAATGTAAATAAGTTCAAAACCTCCCACACCCGCTATGAATAAATTGTTTTAACTACTTATTATGAAATGTAAATTTCGTAATTTTACGATTATACTTTTTAGTCAAATTACGTTTTAACTACTTATTATGAAATGTAAATGTAACAAGTAGTGTTATACCTGCAACAATACCAGTGTTTTAACTACTTATTATGAAATGTAAATTGGAAATGGGAAGAAAGAAATGCACTGATTGTAGAGGTTTTAACTACTTATTATGAAATGTAAATGTCCACATCGACAATAAAAAACACATTGTATCACTTGTTTTAACTACTTATTATGAAATGTAAATCTGGTTACTCAACTGGCGACAGTAATACACCTCAATGTTTTAACTACTTATTATGAAATGTAAATTTTGGATAGGTTGTTTCTGATAAATAGGTTCACGGTTTTAACTACTTATTATGAAATGTAAATAGAAAAAAAACATCTTTCCAATTTGTTGTTTTGCGTTTTAACTACTTATTATGAAATGTAAATACAAGTGCTAGAACAGAAGTTATAATTTGAACATTACGTTTTAACTACTTATTATGAAATGTAAATAGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTAGTTTTAACTACTTATTATGAAATGTAAATTATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGAGTTTTAACTACTTATTATGAAATGTAAATAAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGGGTTTTAACTACTTATTATGAAATGTAAATGTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTTGTTTTAACTACTTATTATGAAATGTAAATTTTTGAAATATGAGGACTTAGAAAATGAAAAAAATGTTTTAACTACTTATTATGAAATCATAAA

>NZ_APIC01000007|1|1|49519-49683|PILER-CR
GTTTTAACTACTTATTATGAAATGTAAATCAATG	CTTAAACCGAGAGCATCAAATTGTTCCCATGCGTTTT
AACTACTTATTATGAAATGTAAATATTACAGTAC	AAGCAAGGGTTATTGAGTTAAATATTGTTTTA
ACTACTTATTATGAAATGTAAATATTAATGATAAGAGCGGAAAGAAAACTTTCAAGGGGTTTTAACTACTTATTATGAAATGTAAATTCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAGGTTTTAACTACTACTTATTATGAAATGTAAATTCGTTTATGACCTTATGAAAGAGTTAACACCTCGACGTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGT
GTTTTAACTACTTATTATGAAATGTAAAT	TGGAAATGGGAAGAAAGAAATGCACTGATTGTAGAG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT


>NZ_APIC01000007|1|1|49519-50846|CRISPRCasFinder
GTTTTAACTACTTATTATGAAATGTAAAT	CAATGCTTAAACCGAGAGCATCAAATTGTTCCCATGC
GTTTTAACTACTTATTATGAAATGTAAAT	ATTACAGTACAAGCAAGGGTTATTGAGTTAAATATT
GTTTTAACTACTTATTATGAAATGTAAAT	ATTAATGATAAGAGCGGAAAGAAAACTTTCAAGGG
GTTTTAACTACTTATTATGAAATGTAAAT	TCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAGGTT
TTAACTACTACTTATTATGAAATGTAAAT	TCGTTTATGACCTTATGAAAGAGTTAACACCTCGAC
GTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGT
GTTTTAACTACTTATTATGAAATGTAAAT	TGGAAATGGGAAGAAAGAAATGCACTGATTGTAGAG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATCATAAA

>NZ_APIC01000007|1|1|49519-50846|CRT
GTTTTAACTACTTATTATGAAATGTAAAT	CAATGCTTAAACCGAGAGCATCAAATTGTTCCCATGC
GTTTTAACTACTTATTATGAAATGTAAAT	ATTACAGTACAAGCAAGGGTTATTGAGTTAAATATT
GTTTTAACTACTTATTATGAAATGTAAAT	ATTAATGATAAGAGCGGAAAGAAAACTTTCAAGGG
GTTTTAACTACTTATTATGAAATGTAAAT	TCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAG
GTTTTAACTACTACTTATTATGAAATGTA	AATTCGTTTATGACCTTATGAAAGAGTTAACACCTCGAC
GTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGT
GTTTTAACTACTTATTATGAAATGTAAAT	TGGAAATGGGAAGAAAGAAATGCACTGATTGTAGAG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTTGAAATATGAGGACTTAGAAAATGAAAAAAAT
GTTTTAACTACTTATTATGAAATCATAAA

>NZ_APIC01000007|1|2|49848-50782|PILER-CR
	CTTAAACCGAGAGCATCAAATTGTTCCCATGCGTTTT
AACTACTTATTATGAAATGTAAATATTACAGTAC	AAGCAAGGGTTATTGAGTTAAATATTGTTTTA
ACTACTTATTATGAAATGTAAATATTAATGATAAGAGCGGAAAGAAAACTTTCAAGGGGTTTTAACTACTTATTATGAAATGTAAATTCCCCCTTAAGATACAAACTCGATTTGACAGGTGCAGGTTTTAACTACTACTTATTATGAAATGTAAATTCGTTTATGACCTTATGAAAGAGTTAACACCTCGACGTTTTAACTACTTATTATGAAATGTAAAT	CTTCCTACTTTTTGACATAAAAAATAAGCCGAGTTG
GTTTTAACTACTTATTATGAAATGTAAAT	AAGTTCAAAACCTCCCACACCCGCTATGAATAAATT
GTTTTAACTACTTATTATGAAATGTAAAT	TTCGTAATTTTACGATTATACTTTTTAGTCAAATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	GTAACAAGTAGTGTTATACCTGCAACAATACCAGT
GTTTTAACTACTTATTATGAAATGTAAAT	TGGAAATGGGAAGAAAGAAATGCACTGATTGTAGAG
GTTTTAACTACTTATTATGAAATGTAAAT	GTCCACATCGACAATAAAAAACACATTGTATCACTT
GTTTTAACTACTTATTATGAAATGTAAAT	CTGGTTACTCAACTGGCGACAGTAATACACCTCAAT
GTTTTAACTACTTATTATGAAATGTAAAT	TTTGGATAGGTTGTTTCTGATAAATAGGTTCACG
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAAAAAAACATCTTTCCAATTTGTTGTTTTGC
GTTTTAACTACTTATTATGAAATGTAAAT	ACAAGTGCTAGAACAGAAGTTATAATTTGAACATTAC
GTTTTAACTACTTATTATGAAATGTAAAT	AGAAGCGTTAGCGGCATTGTTCGAAAGTAATTTA
GTTTTAACTACTTATTATGAAATGTAAAT	TATAAAATATTGCCCAATGTGCGGAAGGAGTTTGGA
GTTTTAACTACTTATTATGAAATGTAAAT	AAGAAATCCGGGAAGTTTTGTTCTACAGAGCGAACGG
GTTTTAACTACTTATTATGAAATGTAAAT	GTGTAATTCTTAATTCCGTATTGATTCGCTAGTTTT
GTTTTAACTACTTATTATGAAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_APIC01000007.1\|WP_003727295.1\|51432_52848_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_APIC01000007.1\|WP_003721310.1\|49042_49321_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_APIC01000007.1\|WP_003731266.1\|56393_56837_+\|hypothetical-protein	unknown	unknown	unknown
NZ_APIC01000007.1\|WP_003731261.1\|44853_45723_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NZ_APIC01000007.1\|WP_003731259.1\|42437_43160_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	pfam01881_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_APIC01000007.1\|WP_003727298.1\|39718_41149_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_APIC01000007.1\|WP_003721301.1\|39240_39672_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_APIC01000007.1\|WP_003731260.1\|43175_44864_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NZ_APIC01000007.1\|WP_003731263.1\|46550_48740_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_APIC01000007.1\|WP_003731268.1\|58683_59424_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_APIC01000007.1\|WP_003725724.1\|36459_36918_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_APIC01000007.1\|WP_003731270.1\|61121_62618_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227617
NZ_APIC01000007.1\|WP_072217746.1\|52979_53984_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_APIC01000007.1\|WP_003731264.1\|50918_51287_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_APIC01000007.1\|WP_003726690.1\|55534_56287_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_APIC01000007.1\|WP_003731262.1\|45700_46483_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|273860
NZ_APIC01000007.1\|WP_003731267.1\|56882_58544_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_APIC01000007.1\|WP_003731269.1\|59653_61129_+\|hypothetical-protein	unknown	unknown	unknown
NZ_APIC01000007.1\|WP_003726689.1\|54016_55333_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_APIC01000007.1\|WP_003727297.1\|41269_42085_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483

Protein	Function_ID	Function_description	E-value
NZ_APIC01000007.1\|WP_003727295.1\|51432_52848_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.97112e-80
NZ_APIC01000007.1\|WP_003721310.1\|49042_49321_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.1393e-30
NZ_APIC01000007.1\|WP_003731267.1\|56882_58544_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	7.67986e-148
NZ_APIC01000007.1\|WP_003731261.1\|44853_45723_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	3.68641e-55
NZ_APIC01000007.1\|WP_003731259.1\|42437_43160_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.25848e-32
NZ_APIC01000007.1\|WP_003727298.1\|39718_41149_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	2.66378e-99
NZ_APIC01000007.1\|WP_003721301.1\|39240_39672_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NZ_APIC01000007.1\|WP_003731260.1\|43175_44864_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	3.08159e-26
NZ_APIC01000007.1\|WP_003731263.1\|46550_48740_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	9.60751e-60
NZ_APIC01000007.1\|WP_003731268.1\|58683_59424_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	9.74e-52
NZ_APIC01000007.1\|WP_003725724.1\|36459_36918_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	9.49445e-13
NZ_APIC01000007.1\|WP_072217746.1\|52979_53984_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	5.54874e-21
NZ_APIC01000007.1\|WP_003731264.1\|50918_51287_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	1.68051e-41
NZ_APIC01000007.1\|WP_003726690.1\|55534_56287_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	7.01666e-64
NZ_APIC01000007.1\|WP_003731262.1\|45700_46483_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	3.98256e-24
NZ_APIC01000007.1\|WP_003731270.1\|61121_62618_+\|hypothetical-protein	gnl\|CDD\|227617	COG5298, COG5298, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_APIC01000007.1\|WP_003726689.1\|54016_55333_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_APIC01000007.1\|WP_003727297.1\|41269_42085_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	4.22926e-50

>NZ_APIC01000007.1|WP_003721310.1|49042_49321_+|CRISPR-associated-endonuclease-Cas2
MYVILIYDISIENGGAKVWRNVFKICKKYLTHVQKSVFEGEITPALLVKLRMELDKYIRDDQDSVIVFSSRQQRWLEKEFWGLTDEKTSNFF
>NZ_APIC01000007.1|WP_003731263.1|46550_48740_+|CRISPR-associated-helicase/endonuclease-Cas3
MQKYLAKSNPEETIQEHTDNLLKNYQRLKKLYPAVEIDWYLLELVCLLHDLGKMNLLFQTKLGNASGKGKEIPHGYLSVAFVPDSKLEEMGYSEDEIKVVYQAIARHHERKYDFSDSEWKKEIIKLEEQWAGFIYSQLGENAEYSSEVEMLYFYPGSRIFEGNSAADAETFKKYVLLKGLLNRIDFAASGGIDVELENDFLMDSMEVQLAHFKAENPEADWNALQKYMMQHQNENIVVIAETGMGKTEAGLLWLGNNKGFFTLPLRAAINAIYERITKNIVTTNQAERVGLLHSETYSQYLLHEGNAEMDIDEYYTRTRQMSLPITICTLDQLFDFVFRYAGFEHKLATLSYSKVIIDEIQMYSPDLLAYLILGLSYIDKFGGKFCIMTATLPGIVTDLLLENGVDFVQPEEKFVSSRIRHSMEMVHTEVESEFIKPFFNNNRILVICNTISKAKKIYSELKEHFQGEEIHLIHSQFIKRDRSAKEKAIFEDGQKDSTKKCIWVATQVVEASLDIDFDLLFTELSDVNGLFQRMGRCYRNRRLDVDTNVYVFDGGAKVCSGVGIDNFIDKLIFENSKTILNEHAGVLTEEKKMELVEQVYSTEALSGSKFYKELIRTINYVKAFESYLMNKADVRRRFRNINSVSVIPEEVWQDNAEEINSYFVTLRKTSKEISTKEKIIARTNLAEFMVSIPDYLYKKGESVVREINRYESVIEFKCGYSSDVGVFMR
>NZ_APIC01000007.1|WP_003731262.1|45700_46483_+|type-I-B-CRISPR-associated-protein-Cas5
MLIMKAIRVKLWQDLVNFKKPTSFQLKETYPLPPYSTVIGMVHTLCGFTSYHEMKISIQGKYFSKVNDLATRYEFKNGMTYDASRHQIKVDKYGVSRGVSTVELLVDLELLLHIIPEDPSLVPIIEKAFREPIEFPSLGRREDIATIQKVEVVDVEKRQPKKSTEISDGYNAYVPISLTENNSVHFKSHESSVGRDKLLGTRYLLTEKYERVNHGTEKAPKFFRKWRKKDVIYSSRIFVSKKDVFFFDEDDYLVFIEEEE
>NZ_APIC01000007.1|WP_003731261.1|44853_45723_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKNKGLAMTIIFQAESANYGESLGNISSLKKISRNNGDQYTYISRQAIRYNLMDQIGEKEAPVKAEGGGDKKVIQFLSEATITDFPELDFFGYLKTEKGSGGQKRSAKVRLSNAISLETFKGDLDFLTNKGQADKLNENMNIAQAEIHKSYYRYTMTIDLDQIGIDGEIALENKEKARRVKKLMDTVAFLYRDIRGRREDLKPLFVIGGVYDVKNPVFQNVVDVADNNIVIKNIKDLLTYEDIKENTRVGIIDGQFANSDEVKAELKAESVPAFFNDIKGKIDAYYESN
>NZ_APIC01000007.1|WP_003731260.1|43175_44864_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MRTEIEVRANDWLINAGLIGFLNIVGKENVRIDGQSIYFTADLLEDFETKYFNFFIQEFKETLSWYKIVSYKETMEQFRIDEFASFDEVALGNLNKYMKDVVKFYLKKVNYIKVFPLIDPSANVTKWLENLNTINLTKKQRWDEVKADIIEEVKQTYTQLDLIIDFCASEKGLQYLGAKNLIYSVINKGWSGVSFLFKQTKFIDPYLDYKTTFVDSVLDYLDTDLSKAKYNCFNCNQPIKNLKLDLSFMNDVGFDTARKTSHVWDFNNDVATCPICRLIYSCVPAGFTYVYGEGMFVNDSYGVEELHRVNERMRNSILSFNQDGINSTNTYRALVESITMEHENNRRYELADIQLVRYENEHYRFNLLSKKMLHIVNDSKGILKGLIRCGYKEGNLNVNLYKEVLQHLMNNENLFTLIHKLIYYKQTSVNGLYYNMGHVSGILDINTKFLKEMEVMTNISQNQLWFVQNCGKEFKEGYVKKKSENKISGITYKLLNSLKVNDKDGFMDTLLNSYSYLAMPIPDVFIKMFSDNEAFKSVGYAFMLGVGGEKTKKEDGGNTDEK
>NZ_APIC01000007.1|WP_003731259.1|42437_43160_+|CRISPR-associated-endoribonuclease-Cas6
MRLKINCDFDSKIIPKDFQSKVVSLFKAGIMKSSPERYENLFGGNKHKQYTFSVYLPKPQNKGAEIQLNEANCIINFSTGDAETGIIFYNALISLRGSKILFGAGNNITIKNIQIVPEKKIIGNRTILRTLSPVVSRDHNRETFKNWFYSFEDEEFEPTLKRNMLPYLIDAFGEQARYDLEKLKITPISMKKVVVYCHEIHIESSVGIFELEAEAYLQKYLVENGLGTMTGSGFGMIEQL
>NZ_APIC01000007.1|WP_003727297.1|41269_42085_-|histidine-phosphatase-family-protein
MKKNIFKLMMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGISPKDFADSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_APIC01000007.1|WP_003727298.1|39718_41149_-|CapA-family-protein
MKRRTYVIITGLVLIFVAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLNQLIKELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKTDEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHVAFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKENTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NZ_APIC01000007.1|WP_003721301.1|39240_39672_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_APIC01000007.1|WP_003725724.1|36459_36918_-|winged-helix-turn-helix-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTTAGKELENELGAAQRKQMAEIFANSSDTDGLHFTEVMEGYAKNRPGAALIKDFKE
>NZ_APIC01000007.1|WP_003731264.1|50918_51287_-|DUF1304-domain-containing-protein
MAILAFILTFIVMIEHIYIMILEMFFANTNLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGMAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVVVLLV
>NZ_APIC01000007.1|WP_003727295.1|51432_52848_+|multidrug-efflux-MFS-transporter
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGLALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK
>NZ_APIC01000007.1|WP_072217746.1|52979_53984_+|ROK-family-transcriptional-regulator
MAIPRDLKELNKKNIKSILRQQGAMTKAEIAEVTGLSVVTVNKLIRDLVENDEILEQDNSVATGGRRAVSYEINPNFQQVLVISLQEKWKKITYSFSVYNLLGEPEFVEDMSGEDLDITALKRNTKDLVCAFPKISCVVIGVPGIEIGGKLRAMDFPLLLNVQLRETLEAEVNLPVLVETDTNAAILGYKNRPVKEENIVGLYYPERFPPGAGLLMNGEILKGQNGLAGEIKHMPLQVDWDNFDFSVDEIKAHIRKMVLLTMSFYDPETIVLYTNFYFGQKDFTEELTEELKQVYPYAVLPEIVLSRKFTTDYRIGLLAFGIDYLENNMTDWRI
>NZ_APIC01000007.1|WP_003726689.1|54016_55333_-|6-phospho-beta-glucosidase
MTKGIKIATIGGGSSYTPELIEGFIKRQDELPVRELWLVDVEAGREKLEIVGNLAKRMVEKAGVDMEVHLTLDREEALKDADFVTTQLRVGLLDARVKDERIPNSYGVVGQETNGPGGMFKGLRTIPVILDICKDMERLCPDAWLINFANPAGMVTEAVLRYSNQKKVVGLCNGPIGIERNIAETLGVDVSEIYVEFVGLNHMVFAKTVYHNGKDVTKDVVFKMTEDEAGSSLKNINATGWDKTFLRTLNMIPIDYLRYYWQTKQQLEDQARAYAEHGTRAEVVKKVEAELFELYKQEELAEKPKQLEQRGGAYYSEAACNLINSIYNDKRDIQIVNTRNNGAILDIDPDSAVETNCVITRQGPIPLASGRLPIAINGIIQEIKTFERLTAEAAVTGDYDKALLAMTINPLTPSESVAREMLDELLEAHKEYLPNFFK
>NZ_APIC01000007.1|WP_003726690.1|55534_56287_+|MurR/RpiR-family-transcriptional-regulator
MLFLDKNLELNDTELDIYNYIVANLDKVVYMRIRDLATEAHVSTTTILRFCRKFGCNGFSEFRVKLQLYLEEQKLAQIDMADETTYIDFLKRTAQPEFKAQIQNAVEILRDRELVLFAGVGSSGVIAEYGAIYFSSLFTLALHIEDPLNHPFYHLSSKLSDKICMIAISVEGENEDIIRYIHQLKAQNCKVISITNSAKSTIARLSDANIAYYINKEMYQEANITSQLPALYTIENIAREIRTQIDKEKM
>NZ_APIC01000007.1|WP_003731266.1|56393_56837_+|hypothetical-protein
MYSNRKEKVVFTLIMCSLMILCMSSYNIFLENGIGANSFMIILKAFVPFLFIGFLLDFFVVGKIVYRLHAHLVSEDASKFKKIIMMQLLMVTFMCVLMSTLSLIVNQGEWSHLGILILRNYFVALFLQIFIVSPFVRLISPRIFALL
>NZ_APIC01000007.1|WP_003731267.1|56882_58544_-|SulP-family-inorganic-anion-transporter
MFKHILLSLNGYKISYLRNDVISGVGVAALTIPVAMGYAQVAGLPPIYGLYASFLPVIAYVIFASSPQLVFGIDATASAITGSIILGTAGLAAGSKEAIALAPILAFFCAIFLVLFSVLKLGRFAKYISAPVLSGFISGLSVSIIMGQIPKIMGLKESGDSFFSSLGIIFGQFFQSNWISFAMGVVTVIIVITCKKVIPKIPMSLVVLILGTMAAYFFKLDQYNVDIVGKIPVGFPSLALPDFGASSWALAIGGGLVCAIATFAGSLLPSESFAMRNKYTIDDNRELFAYGISNFVAAFSGCSPASASVSRTAANEQFRGKTQMVSIVAATIIALIVAFLSGLLYYMPQPVLSGIVFAALVGIIDVDVLKGLFKVSRREATVWIVAALGTLLVGVIFGVLLGIFLSFINVVSRSMKSPIAILGVIEGRHGYFDLKRKPEAKPIPNVVIYRYSASLFFGNFNKFADGLKEAVQDDTKLVIFEASAIINIDTTATESMKDLLKWLDDKGIEYYFADLIDHLKTSFRKHDLGYIIDNGYTKKTVEDALEAYYAEHK
>NZ_APIC01000007.1|WP_003731268.1|58683_59424_-|MerR-family-transcriptional-regulator
MQIKELAELTGVSVRTLHHYDKIGLLVPQKDDRNGYRIYSENDVDKLQQILFFKELDFPLKKIKQILDDPFFDKNVALDLQRHLLIEKKQRIETMLATLDQTIRNEKGEITMTNKEKFTGFDFSTNPYEEEAKKRWGDKVVEKANEKVNNMNEKEKLTLKESFDAEFRHLASVRELSPESEEAQLAIDHFFHYLNDTHGNIYSLEAFADLGEMYVADERFTKNIDQFGDGLSHFLKEAMNIYAKNK
>NZ_APIC01000007.1|WP_003731269.1|59653_61129_+|hypothetical-protein
MIGKVKSISMWLWHHLTPQIFAVICVFIITLIALFMPPYIGMADNGDFFRIFSSNGLFVNNTNYDALQFGHFVKEFGIYQYFNENQVAIYSSQSIFIQMALLLNKLFWSTTVFDVRFLGGLQLALLLPAIYLLVAGLTAKMKGWPGYVVAALTVFIFADTAYTAYFNSFFSEGLILIMMLYISAGFLLLYQHKYNDYAMLGLIFVASLILITAKQQNAPIAVVIAVCGILVFFIRKNRAFRISAAATFFVIFLSGVVMYAFIPGEFVTINQYQTMTRGVLLDSENPEKSLEEMGMNSEFALLKGTNFYQKYKMIDLDSKLMEKEFYPNYNFVTVLSYYLENPKQFGKMLDLSAQNSFSIRPFEMGNFEKATGYKFKEKTHFFSIYSDVKEKLAPAKFTFLILWALVFLICYGVSAFKHFREKNIRGMLLFDLVVLLIGSGFAVILVTIVGDGEADLTKHNFLFNVCFDLTMLIGAASLLEVYMKKRGERNA
>NZ_APIC01000007.1|WP_003731270.1|61121_62618_+|hypothetical-protein
MRKKLIVSILLAFMIFVVGGHSAIAKSDDGVVVFYDSLATGTENEGNMDALLRMLNSLGKRVTIYSWEENPDLSQTSEIIVLQNKKDGLSNKWTNKLAKSKAKIAYIGGNPPTFLTDKLQLKTKAITEASITIQTQAGLSGKPQLVNETNLITSYKGTSFGEMDAAENGQAAYGVQAGNYAYAPLFQADNTSEFALMDVLKALFDIKTTTNQYAFITGVNPFIDFDLLKKTADTFYEKGIPFIVSAGPVFYNQDFQAARNYAEILRYVQAKNGTIMMNVPAVTYGDSPAGELEKIMQKSVHFFAENDVAPLGVTAELYWNFDKVYGVEGFAPFNTGILLPNQKIIHTTKVNNGSAFEKSPYSVANDFYATTTEGRNFPIDIAITYSFFDNEKELKAAAEELATDNISDFRFQDHGVKTNKDTIESSAGSLYINNQSVTLDGDLNYIKTKNKTVKQAGSLEGFFGYQNTFFTIVIVLSLGIIGVLFVFGYRLYMKKYMK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_APIC01000007_1	1.14\|50267\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50267-50302	36	NZ_APIC01000014.1	1401-1436	0	1.0
NZ_APIC01000007_1	1.18\|50524\|34\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50524-50557	34	NZ_APIC01000014.1	794-827	0	1.0

1. spacer 1.14|50267|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to position: 1401-1436, mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

2. spacer 1.18|50524|34|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to position: 794-827, mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_APIC01000007_1	1.2\|49624\|32\|NZ_APIC01000007\|PILER-CR	49624-49655	32	DQ003642	Listeria phage A006, complete genome	16676-16707	0	1.0
NZ_APIC01000007_1	1.4\|49614\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT	49614-49649	36	DQ003642	Listeria phage A006, complete genome	16672-16707	0	1.0
NZ_APIC01000007_1	1.5\|49679\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	49679-49713	35	MH341453	Listeria phage PSU-VKH-LP041, complete genome	31167-31201	0	1.0
NZ_APIC01000007_1	1.9\|49942\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	49942-49977	36	KJ094023	Listeria phage LP-101, complete genome	18341-18376	0	1.0
NZ_APIC01000007_1	1.14\|50267\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50267-50302	36	NC_003216	Listeria phage A118, complete genome	18563-18598	0	1.0
NZ_APIC01000007_1	1.14\|50267\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50267-50302	36	AJ242593	Bacteriophage A118 complete genome	18563-18598	0	1.0
NZ_APIC01000007_1	1.18\|50524\|34\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50524-50557	34	NC_003216	Listeria phage A118, complete genome	19172-19205	0	1.0
NZ_APIC01000007_1	1.18\|50524\|34\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50524-50557	34	AJ242593	Bacteriophage A118 complete genome	19172-19205	0	1.0
NZ_APIC01000007_1	1.1\|49553\|37\|NZ_APIC01000007\|PILER-CR	49553-49589	37	KJ094023	Listeria phage LP-101, complete genome	9186-9222	1	0.973
NZ_APIC01000007_1	1.3\|49548\|37\|NZ_APIC01000007\|CRISPRCasFinder,CRT	49548-49584	37	KJ094023	Listeria phage LP-101, complete genome	9186-9222	1	0.973
NZ_APIC01000007_1	1.8\|49877\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	49877-49912	36	KJ094023	Listeria phage LP-101, complete genome	17910-17945	1	0.972
NZ_APIC01000007_1	1.1\|49553\|37\|NZ_APIC01000007\|PILER-CR	49553-49589	37	MT500540	Listeria phage LP-HM00113468, complete genome	35729-35765	2	0.946
NZ_APIC01000007_1	1.3\|49548\|37\|NZ_APIC01000007\|CRISPRCasFinder,CRT	49548-49584	37	MT500540	Listeria phage LP-HM00113468, complete genome	35729-35765	2	0.946
NZ_APIC01000007_1	1.13\|50202\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50202-50237	36	MH341453	Listeria phage PSU-VKH-LP041, complete genome	26132-26167	2	0.944
NZ_APIC01000007_1	1.19\|50587\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50587-50622	36	MH341453	Listeria phage PSU-VKH-LP041, complete genome	41996-42031	3	0.917
NZ_APIC01000007_1	1.8\|49877\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	49877-49912	36	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	227438-227473	4	0.889
NZ_APIC01000007_1	1.21\|50718\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50718-50753	36	FW590615	JP 2010534058-A/25: ANTIBIOTIC RESISTANCE FREE LISTERIA STRAINS AND METHODS FOR CONSTRUCTING AND USING SAME	3844-3879	4	0.889
NZ_APIC01000007_1	1.21\|50718\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50718-50753	36	HI504184	Sequence 26 from Patent EP2147092	3844-3879	4	0.889
NZ_APIC01000007_1	1.21\|50718\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50718-50753	36	AJ417489	bacteriophage U153 int gene for U153 integrase	3844-3879	4	0.889
NZ_APIC01000007_1	1.19\|50587\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50587-50622	36	KJ094023	Listeria phage LP-101, complete genome	32760-32795	5	0.861
NZ_APIC01000007_1	1.16\|50395\|34\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50395-50428	34	NC_022111	Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence	1764851-1764884	6	0.824
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	MN694189	Marine virus AFVG_250M578, complete genome	47879-47913	6	0.829
NZ_APIC01000007_1	1.21\|50718\|36\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50718-50753	36	NC_019743	Microcoleus sp. PCC 7113 plasmid pMIC7113.08, complete sequence	4997-5032	8	0.778
NZ_APIC01000007_1	1.5\|49679\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	49679-49713	35	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	176358-176392	9	0.743
NZ_APIC01000007_1	1.16\|50395\|34\|NZ_APIC01000007\|CRISPRCasFinder,CRT,PILER-CR	50395-50428	34	NZ_CP038863	Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence	39302-39335	9	0.735
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	MK448625	Streptococcus satellite phage Javan738, complete genome	5960-5994	9	0.743
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	MK448449	Streptococcus satellite phage Javan356, complete genome	4490-4524	9	0.743
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	MK448636	Streptococcus satellite phage Javan749, complete genome	6112-6146	9	0.743
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	NZ_CP045037	Lactobacillus mali strain LM596 plasmid unnamed2, complete sequence	34734-34768	9	0.743
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	NZ_CP018177	Lactobacillus hordei strain TMW 1.1822 plasmid pL11822-1, complete sequence	11325-11359	9	0.743
NZ_APIC01000007_1	1.22\|50783\|35\|NZ_APIC01000007\|CRISPRCasFinder,CRT	50783-50817	35	NZ_CP018181	Lactobacillus nagelii strain TMW 1.1827 plasmid pL11827-1, complete sequence	63608-63642	9	0.743

1. spacer 1.2|49624|32|NZ_APIC01000007|PILER-CR matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 0, identity: 1.0

cagtacaagcaagggttattgagttaaatatt	CRISPR spacer
cagtacaagcaagggttattgagttaaatatt	Protospacer
********************************

2. spacer 1.4|49614|36|NZ_APIC01000007|CRISPRCasFinder,CRT matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 0, identity: 1.0

attacagtacaagcaagggttattgagttaaatatt	CRISPR spacer
attacagtacaagcaagggttattgagttaaatatt	Protospacer
************************************

3. spacer 1.5|49679|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 0, identity: 1.0

attaatgataagagcggaaagaaaactttcaaggg	CRISPR spacer
attaatgataagagcggaaagaaaactttcaaggg	Protospacer
***********************************

4. spacer 1.9|49942|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

aagttcaaaacctcccacacccgctatgaataaatt	CRISPR spacer
aagttcaaaacctcccacacccgctatgaataaatt	Protospacer
************************************

5. spacer 1.14|50267|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

6. spacer 1.14|50267|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

ctggttactcaactggcgacagtaatacacctcaat	CRISPR spacer
ctggttactcaactggcgacagtaatacacctcaat	Protospacer
************************************

7. spacer 1.18|50524|34|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to NC_003216 (Listeria phage A118, complete genome) position: , mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

8. spacer 1.18|50524|34|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to AJ242593 (Bacteriophage A118 complete genome) position: , mismatch: 0, identity: 1.0

agaagcgttagcggcattgttcgaaagtaattta	CRISPR spacer
agaagcgttagcggcattgttcgaaagtaattta	Protospacer
**********************************

9. spacer 1.1|49553|37|NZ_APIC01000007|PILER-CR matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.973

caatgcttaaaccgagagcatcaaattgttcccatgc	CRISPR spacer
caatgcttaaacctagagcatcaaattgttcccatgc	Protospacer
************* ***********************

10. spacer 1.3|49548|37|NZ_APIC01000007|CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.973

caatgcttaaaccgagagcatcaaattgttcccatgc	CRISPR spacer
caatgcttaaacctagagcatcaaattgttcccatgc	Protospacer
************* ***********************

11. spacer 1.8|49877|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.972

cttcctactttttgacataaaaaataagccgagttg	CRISPR spacer
cttcctactttttgacataaaaaataagccgaattg	Protospacer
********************************.***

12. spacer 1.1|49553|37|NZ_APIC01000007|PILER-CR matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 2, identity: 0.946

caatgcttaaaccgagagcatcaaattgttcccatgc	CRISPR spacer
caatgcttaacccaagagcatcaaattgttcccatgc	Protospacer
********** **.***********************

13. spacer 1.3|49548|37|NZ_APIC01000007|CRISPRCasFinder,CRT matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 2, identity: 0.946

caatgcttaaaccgagagcatcaaattgttcccatgc	CRISPR spacer
caatgcttaacccaagagcatcaaattgttcccatgc	Protospacer
********** **.***********************

14. spacer 1.13|50202|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 2, identity: 0.944

gtccacatcgacaataaaaaacacattgtatcactt	CRISPR spacer
gtccacattgacaacaaaaaacacattgtatcactt	Protospacer
********.*****.*********************

15. spacer 1.19|50587|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 3, identity: 0.917

tataaaatattgcccaatgtgcggaaggagtttgga	CRISPR spacer
tataaaatattgtccaatgtgtggaaggagtttggg	Protospacer
************.********.*************.

16. spacer 1.8|49877|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 4, identity: 0.889

cttcctactttttgacataaaaaataagccgagttg	CRISPR spacer
cttcctactttttgacataaaaaataagccttgctc	Protospacer
******************************  *.*

17. spacer 1.21|50718|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to FW590615 (JP 2010534058-A/25: ANTIBIOTIC RESISTANCE FREE LISTERIA STRAINS AND METHODS FOR CONSTRUCTING AND USING SAME) position: , mismatch: 4, identity: 0.889

gtgtaattcttaattccgtattgattcgctagtttt	CRISPR spacer
ttataatccttaattccgtattgatttgctagtttt	Protospacer
 *.****.******************.*********

18. spacer 1.21|50718|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to HI504184 (Sequence 26 from Patent EP2147092) position: , mismatch: 4, identity: 0.889

gtgtaattcttaattccgtattgattcgctagtttt	CRISPR spacer
ttataatccttaattccgtattgatttgctagtttt	Protospacer
 *.****.******************.*********

19. spacer 1.21|50718|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to AJ417489 (bacteriophage U153 int gene for U153 integrase) position: , mismatch: 4, identity: 0.889

gtgtaattcttaattccgtattgattcgctagtttt	CRISPR spacer
ttataatccttaattccgtattgatttgctagtttt	Protospacer
 *.****.******************.*********

20. spacer 1.19|50587|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 5, identity: 0.861

tataaaatattgcccaatgtgcggaaggagtttgga	CRISPR spacer
cattgaattttgcccaatgtgcggaaggagcttgga	Protospacer
.** .*** *********************.*****

21. spacer 1.16|50395|34|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to NC_022111 (Prevotella sp. oral taxon 299 str. F0039 plasmid, complete sequence) position: , mismatch: 6, identity: 0.824

agaaaaaaaacatctttccaatttgttgttttgc	CRISPR spacer
agcaaaaaaacatctttcctatttgttttatcac	Protospacer
** **************** ******* * *..*

22. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to MN694189 (Marine virus AFVG_250M578, complete genome) position: , mismatch: 6, identity: 0.829

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
taataaaaaatgagggcttagaaaatgaaaaaatt	Protospacer
*  *.*** ******.***************** *

23. spacer 1.21|50718|36|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to NC_019743 (Microcoleus sp. PCC 7113 plasmid pMIC7113.08, complete sequence) position: , mismatch: 8, identity: 0.778

gtgtaattcttaattccgtattgattcgctagtttt---	CRISPR spacer
gtgtaattcttactgccgtattgatt---taactctgaa	Protospacer
************ * ***********   **..*.*

24. spacer 1.5|49679|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 9, identity: 0.743

attaatgataagagcggaaagaaaactttcaaggg	CRISPR spacer
gaaattaaaaagagagcaaagaaaactttcaagga	Protospacer
.  * *.* ***** * *****************.

25. spacer 1.16|50395|34|NZ_APIC01000007|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP038863 (Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

agaaaaaaaacatctttccaatttgttgttttgc-----	CRISPR spacer
aagaaaaaaacatatttccaatt-----ttttccaaaaa	Protospacer
*..********** *********     **** *

26. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to MK448625 (Streptococcus satellite phage Javan738, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtatgaactatgaggacttagaaagtgaagacctg	Protospacer
 * **** ****************.****.*

27. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to MK448449 (Streptococcus satellite phage Javan356, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtatgaactatgaggacttagaaagtgaagacctg	Protospacer
 * **** ****************.****.*

28. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to MK448636 (Streptococcus satellite phage Javan749, complete genome) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
gtctgaactatgaggacttagaaagtgaagacctg	Protospacer
 *.**** ****************.****.*

29. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to NZ_CP045037 (Lactobacillus mali strain LM596 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

30. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to NZ_CP018177 (Lactobacillus hordei strain TMW 1.1822 plasmid pL11822-1, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

31. spacer 1.22|50783|35|NZ_APIC01000007|CRISPRCasFinder,CRT matches to NZ_CP018181 (Lactobacillus nagelii strain TMW 1.1827 plasmid pL11827-1, complete sequence) position: , mismatch: 9, identity: 0.743

ttttgaaatatgaggacttagaaaatgaaaaaaat	CRISPR spacer
ttaagaaatataaggacttagtaaatgaagttatg	Protospacer
**  *******.********* *******.  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

174774 : 206599

Listeria_phage(48.48%)

head,integrase,protease,capsid,tail,terminase,portal,holin

attL 167343:167357|attR 188575:188589

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
167343:167357	attL	NA	NA	NA	NA
WP_014929921.1\|174774_175809_+	DUF4236 domain-containing protein	A0A2K9V2W7	Faecalibacterium_phage	3.0e-13	68.3
WP_014930665.1\|175965_177117_-\|integrase	site-specific integrase	A8ATX2	Listeria_phage	4.5e-87	46.3
WP_023552237.1\|177138_177852_-	hypothetical protein	A0A0B5CTT6	Listeria_phage	1.1e-35	36.1
WP_014930667.1\|177906_178407_-	hypothetical protein	A0A1S7FYX8	Listeria_phage	1.9e-13	31.9
WP_012951299.1\|178419_178746_-	helix-turn-helix transcriptional regulator	A0A2H4J6F9	uncultured_Caudovirales_phage	2.5e-11	35.1
WP_039378858.1\|178919_179120_+	helix-turn-helix transcriptional regulator	Q0H243	Geobacillus_phage	6.5e-10	52.3
WP_012951301.1\|179217_179544_+	DUF771 domain-containing protein	A0A2H4J474	uncultured_Caudovirales_phage	4.9e-15	41.1
WP_014930669.1\|179716_180757_+	conserved phage C-terminal domain-containing protein	A0A1W6JNI1	Staphylococcus_phage	2.1e-51	49.4
WP_014930670.1\|180758_181115_+	HTH domain-containing protein	A8ATZ8	Listeria_phage	1.0e-05	37.5
WP_014930672.1\|181525_181702_+	hypothetical protein	A8ATL8	Listeria_phage	1.3e-14	69.0
WP_031670005.1\|181715_182240_+	hypothetical protein	A0A059T5F9	Listeria_phage	1.2e-90	90.8
WP_039378864.1\|182248_182713_+	class I SAM-dependent methyltransferase	A8ATY8	Listeria_phage	9.9e-86	94.8
WP_039378866.1\|182709_183111_+	hypothetical protein	A8ASP1	Listeria_phage	9.3e-40	58.2
WP_039378868.1\|183107_183569_+	hypothetical protein	A0A0C5K8Z3	Enterococcus_phage	2.5e-12	34.2
WP_039378870.1\|183565_184081_+	hypothetical protein	C9E2P0	Enterococcus_phage	1.1e-32	46.2
WP_039194683.1\|184077_184287_+	hypothetical protein	A8ATE0	Listeria_phage	1.6e-30	94.2
WP_039194681.1\|184390_184570_+	hypothetical protein	A0A076G7F4	Listeria_phage	1.4e-19	85.5
WP_039378873.1\|184566_185046_+	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	2.5e-68	83.8
WP_039187812.1\|185066_185306_+	hypothetical protein	NA	NA	NA	NA
WP_039187808.1\|185296_185482_+	hypothetical protein	NA	NA	NA	NA
WP_023552279.1\|185552_186071_+	hypothetical protein	NA	NA	NA	NA
WP_023552281.1\|186067_186610_+\|integrase	tyrosine-type recombinase/integrase	H0USV4	Bacillus_phage	2.5e-48	53.3
WP_014930678.1\|186625_186964_+	hypothetical protein	NA	NA	NA	NA
WP_039378875.1\|187228_187555_+	hypothetical protein	NA	NA	NA	NA
WP_052199047.1\|187551_187914_+	HNH endonuclease	A0A075M5R4	Enterococcus_phage	3.5e-14	44.1
WP_012951321.1\|188008_188536_+\|terminase	phage terminase small subunit P27 family	J7KC46	Streptococcus_phage	6.1e-31	46.7
WP_049955710.1\|188504_190256_+\|terminase	terminase large subunit	A0A2H4JCI4	uncultured_Caudovirales_phage	2.9e-154	50.4
188575:188589	attR	NA	NA	NA	NA
WP_031669998.1\|190262_190463_+	DUF1056 family protein	NA	NA	NA	NA
WP_039378878.1\|190465_191710_+\|portal	phage portal protein	A0A2H4JAR2	uncultured_Caudovirales_phage	5.8e-80	41.5
WP_049955709.1\|191706_192273_+\|head,protease	HK97 family phage prohead protease	A0A1D6Z2A7	Staphylococcus_phage	2.7e-45	52.7
WP_049955708.1\|192337_193507_+\|capsid	phage major capsid protein	A0A060AI54	Enterococcus_phage	9.6e-45	38.1
WP_012951326.1\|193555_193894_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_031669990.1\|193863_194184_+\|head	phage head closure protein	NA	NA	NA	NA
WP_031669989.1\|194177_194543_+	HK97 gp10 family phage protein	B4XYP9	Lactobacillus_phage	5.3e-10	38.2
WP_031669988.1\|194546_194945_+	hypothetical protein	NA	NA	NA	NA
WP_039378894.1\|194965_195541_+\|tail	phage major tail protein	M1PRQ7	Streptococcus_phage	2.7e-32	41.8
WP_031669986.1\|195630_195978_+	hypothetical protein	NA	NA	NA	NA
WP_158231546.1\|195992_196157_+	hypothetical protein	NA	NA	NA	NA
WP_039378881.1\|196174_200374_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	1.2e-12	33.0
WP_014930683.1\|200366_202610_+\|tail	phage tail family protein	A0A059T682	Listeria_phage	1.2e-56	29.4
WP_039378882.1\|202615_204907_+\|tail	phage tail protein	A0A059T7Y6	Listeria_phage	2.2e-133	37.8
WP_039378885.1\|204899_205964_+	hypothetical protein	A0A059T7R4	Listeria_phage	1.5e-108	58.0
WP_003722523.1\|206002_206368_+	hypothetical protein	Q9T1A0	Listeria_phage	7.4e-12	100.0
WP_039378887.1\|206380_206599_+\|holin	holin	R4IDW2	Listeria_phage	8.1e-30	94.5

Anti-CRISPR protein detection

Acr_ID: NZ_APIC01000007.1|WP_039378866.1|182709_183111_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_APIC01000007.1|WP_039378866.1|182709_183111_+|hypothetical-protein

182709_183111_+

133 aa aa

174774-206599

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_APIC01000001_2	TypeII	2.11\|510859\|31\|NZ_APIC01000001\|CRISPRCasFinder,CRT	510859-510889	31	204410-204380	0
NZ_APIC01000001_2	TypeII	2.15\|510861\|29\|NZ_APIC01000001\|PILER-CR	510861-510889	29	204409-204381	0

1. spacer 2.11|510859|31|NZ_APIC01000001|CRISPRCasFinder,CRT matches to NZ_APIC01000007 position: 204410-204380, mismatch: 0

tatagtctgttttttcgtaagtgagcagcgc	CRISPR spacer
tatagtctgttttttcgtaagtgagcagcgc	Protospacer
*******************************

2. spacer 2.15|510861|29|NZ_APIC01000001|PILER-CR matches to NZ_APIC01000007 position: 204409-204381, mismatch: 0

atagtctgttttttcgtaagtgagcagcg	CRISPR spacer
atagtctgttttttcgtaagtgagcagcg	Protospacer
*****************************

6. NZ_APIC01000013

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

25454 : 34299

Streptococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003728469.1\|25454_28370_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.9e-174	36.7
WP_003728468.1\|28373_28928_-	recombinase family protein	A0A0F7LA37	Escherichia_phage	7.0e-38	53.4
WP_003728467.1\|29207_29567_+	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	3.1e-26	50.0
WP_003728466.1\|29566_31702_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.6e-247	64.5
WP_003728465.1\|31894_32236_-	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_003728464.1\|32229_32472_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_003728463.1\|32532_32784_-	hypothetical protein	NA	NA	NA	NA
WP_003728462.1\|32914_33241_+	hypothetical protein	A0A2K9V3N4	Faecalibacterium_phage	3.2e-06	40.8
WP_003731676.1\|33240_33903_+	DUF2786 domain-containing protein	NA	NA	NA	NA
WP_003769263.1\|33921_34299_+	DUF3850 domain-containing protein	C9E2N9	Enterococcus_phage	2.2e-14	55.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_APIC01000002

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1645 : 60254

Streptococcus_phage(15.79%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003727526.1\|1645_2785_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_003723563.1\|2864_3260_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|3410_3626_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003727523.1\|3749_4283_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003731300.1\|4298_4964_+	hypothetical protein	NA	NA	NA	NA
WP_003727521.1\|5225_6164_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|6278_7562_+	trigger factor	NA	NA	NA	NA
WP_003723886.1\|7746_9006_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.4e-145	63.2
WP_003726393.1\|9124_9691_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_003731301.1\|9725_10295_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003727520.1\|10396_10939_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003726396.1\|10948_11812_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_003727519.1\|11808_12594_+	ribonuclease HII	G4YAY0	Emiliania_huxleyi_virus	6.7e-26	37.6
WP_003727518.1\|12727_13588_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	3.1e-40	47.2
WP_003727517.1\|13860_15939_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	5.4e-107	37.5
WP_003731302.1\|16001_17306_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_003731303.1\|17588_18491_+	tyrosine recombinase XerC	A0A1B1IQT7	uncultured_Mediterranean_phage	1.6e-23	28.0
WP_003724001.1\|18511_19051_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_003727514.1\|19064_20474_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IBU3	Erwinia_phage	4.0e-29	26.0
WP_003726695.1\|20494_21274_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_003727513.1\|21376_21796_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_003724130.1\|21818_22130_+	hypothetical protein	NA	NA	NA	NA
WP_003726697.1\|22132_23005_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_003726698.1\|23046_23643_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003731304.1\|23800_24208_+	CoA-binding protein	NA	NA	NA	NA
WP_003727510.1\|24388_26356_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	5.1e-123	42.5
WP_003726814.1\|28896_29364_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_003731305.1\|29991_31812_+	class 1 internalin InlK	NA	NA	NA	NA
WP_039378159.1\|31844_33731_-	peptidoglycan O-acetyltransferase OatA	B5WZU0	Pseudomonas_phage	3.8e-43	32.2
WP_003726657.1\|33943_34642_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	6.4e-12	31.9
WP_039378162.1\|34874_36551_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_003726658.1\|36677_37595_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|37716_37950_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_012681271.1\|38060_39284_+	GTPase HflX	NA	NA	NA	NA
WP_003727505.1\|39276_40503_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|40704_41073_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_003723435.1\|41143_42478_+	type I glutamate--ammonia ligase	M1NM71	Moumouvirus	4.2e-12	23.8
WP_003731338.1\|42621_43917_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	1.3e-146	62.1
WP_003726565.1\|43950_44475_-	GNAT family N-acetyltransferase	G9BWD5	Planktothrix_phage	1.0e-06	31.1
WP_003723438.1\|44505_45120_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_003727502.1\|45275_45605_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_003727501.1\|45698_45926_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_003731337.1\|46072_48067_+	transketolase	NA	NA	NA	NA
WP_003726667.1\|48287_48527_+	YneF family protein	NA	NA	NA	NA
WP_003726668.1\|48575_49307_-	class I SAM-dependent methyltransferase	A0A1X9I6N4	Streptococcus_phage	2.3e-81	58.0
WP_003726669.1\|49328_49835_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	1.4e-56	66.7
WP_003731336.1\|49844_51149_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	1.2e-133	52.1
WP_077916361.1\|51138_52353_-	helicase SNF2	L0P6E9	Lactobacillus_phage	2.1e-90	46.3
WP_003727498.1\|52330_52705_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|52997_53726_+	UMP kinase	NA	NA	NA	NA
WP_003723450.1\|53725_54283_+	ribosome recycling factor	NA	NA	NA	NA
WP_003727497.1\|54513_55272_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	4.4e-22	42.1
WP_003727496.1\|55285_56074_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_003731335.1\|56088_57231_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_003726415.1\|57244_58507_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_003726416.1\|58547_60254_+\|tRNA	proline--tRNA ligase	NA	NA	NA	NA

DBSCAN-SWA_2

419812 : 466908

Listeria_phage(98.55%)

holin,plate,terminase,integrase,head

attL 419259:419278|attR 466942:466961

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
419259:419278	attL	NA	NA	NA	NA
WP_003731544.1\|419812_420178_+	hypothetical protein	A8ATJ4	Listeria_phage	6.4e-56	94.2
WP_023559354.1\|420191_420395_+	hypothetical protein	A8ATJ3	Listeria_phage	2.6e-30	95.5
WP_003731542.1\|420422_420644_+	helix-turn-helix transcriptional regulator	A8ATJ2	Listeria_phage	3.5e-33	95.9
WP_003731541.1\|420705_421539_-	N-acetylmuramoyl-L-alanine amidase	A0A1S7FZ94	Listeria_phage	2.5e-47	43.8
WP_003731540.1\|421541_421796_-\|holin	phage holin	A8ATJ0	Listeria_phage	2.5e-38	96.4
WP_023559355.1\|421806_422022_-	LysM peptidoglycan-binding domain-containing protein	A8ATI9	Listeria_phage	6.3e-27	94.4
WP_003731538.1\|422041_422488_-	hypothetical protein	A8ATI8	Listeria_phage	1.7e-63	95.9
WP_003731537.1\|422463_422910_-	hypothetical protein	A8ATI7	Listeria_phage	9.3e-73	97.3
WP_003731536.1\|423095_423437_-	hypothetical protein	A8ATI5	Listeria_phage	1.5e-43	93.5
WP_003731535.1\|423442_424171_-	hypothetical protein	A8ATI4	Listeria_phage	2.7e-130	93.4
WP_003731534.1\|424191_424833_-	hypothetical protein	A8ATI3	Listeria_phage	4.5e-113	99.1
WP_003731533.1\|424822_425974_-\|plate	baseplate J/gp47 family protein	A8ATI2	Listeria_phage	5.4e-165	76.8
WP_003731532.1\|425966_426329_-	DUF2634 domain-containing protein	A8ATI1	Listeria_phage	2.0e-41	70.0
WP_003731531.1\|426325_426664_-	hypothetical protein	A8ATI0	Listeria_phage	8.0e-53	92.0
WP_003731530.1\|426664_427471_-	hypothetical protein	A8ATH9	Listeria_phage	3.0e-130	85.8
WP_003731529.1\|427476_427848_-	hypothetical protein	A8ATH8	Listeria_phage	5.4e-50	77.0
WP_023559357.1\|427847_428396_-	LysM peptidoglycan-binding domain-containing protein	A8ATH7	Listeria_phage	5.4e-83	84.5
WP_031642246.1\|428401_433438_-	peptidoglycan DD-metalloendopeptidase family protein	A8ATH6	Listeria_phage	0.0e+00	74.7
WP_031642248.1\|433439_433652_-	hypothetical protein	A8ATH5	Listeria_phage	1.9e-28	91.4
WP_049961612.1\|433614_433971_-	hypothetical protein	A8ATH4	Listeria_phage	2.3e-58	97.5
WP_052199042.1\|434023_434431_-	hypothetical protein	A8ATH3	Listeria_phage	1.7e-65	96.3
WP_003731523.1\|434447_435443_-	DUF3383 family protein	A8ATH2	Listeria_phage	1.9e-182	100.0
WP_003731522.1\|435447_435936_-	hypothetical protein	A8ATH1	Listeria_phage	3.2e-87	100.0
WP_039378279.1\|435925_436300_-	hypothetical protein	A8ATH0	Listeria_phage	8.6e-64	97.6
WP_039378281.1\|436299_436899_-	hypothetical protein	A8ATG9	Listeria_phage	2.6e-110	99.5
WP_003731519.1\|436898_437234_-	DUF4054 domain-containing protein	A8ATG8	Listeria_phage	2.1e-53	100.0
WP_039378284.1\|437245_437632_-	hypothetical protein	A8ATG7	Listeria_phage	2.1e-65	98.4
WP_039378286.1\|437654_438560_-	encapsulin	A8ATG6	Listeria_phage	1.1e-160	96.7
WP_003731516.1\|438580_439030_-	hypothetical protein	A8ATG5	Listeria_phage	9.0e-76	100.0
WP_039378288.1\|439029_440139_-	DUF2213 domain-containing protein	A8ATG4	Listeria_phage	9.4e-175	99.5
WP_003731514.1\|440187_440358_-	hypothetical protein	A8ATG3	Listeria_phage	1.1e-26	100.0
WP_039378291.1\|440354_441764_-\|head	phage head morphogenesis protein	A8ATG2	Listeria_phage	2.4e-260	97.2
WP_003731512.1\|441756_443142_-	DUF1073 domain-containing protein	A8ATG1	Listeria_phage	1.1e-265	100.0
WP_039378293.1\|443155_444616_-\|terminase	phage terminase large subunit	A8ATG0	Listeria_phage	9.8e-289	99.8
WP_039378295.1\|444593_445478_-	hypothetical protein	A8ATF9	Listeria_phage	3.6e-137	98.0
WP_039378298.1\|445519_445807_-	hypothetical protein	A0A0S2MYE7	Enterococcus_phage	5.3e-21	58.7
WP_039378302.1\|445844_446075_-	hypothetical protein	A8ATN7	Listeria_phage	2.2e-30	90.8
WP_003731507.1\|446204_446402_-	hypothetical protein	A8ATN6	Listeria_phage	5.2e-28	100.0
WP_039378306.1\|446449_447787_-	ParB N-terminal domain-containing protein	A8ATN5	Listeria_phage	2.0e-248	95.7
WP_052199043.1\|447858_448335_-	hypothetical protein	NA	NA	NA	NA
WP_039378311.1\|448649_449417_-	phage antirepressor KilAC domain-containing protein	A8ATN0	Listeria_phage	5.2e-140	98.8
WP_039378368.1\|449429_449852_-	hypothetical protein	A8ATM9	Listeria_phage	1.4e-70	99.3
WP_039378313.1\|449932_450493_-	phage protein	A8ATM8	Listeria_phage	1.7e-100	95.2
WP_039378318.1\|450974_451208_-	DUF3850 domain-containing protein	A0A059T7N3	Listeria_phage	2.7e-15	61.9
WP_039378322.1\|451222_451558_-	hypothetical protein	A8ATZ5	Listeria_phage	5.4e-09	96.6
WP_039378324.1\|451538_451751_-	hypothetical protein	NA	NA	NA	NA
WP_003727764.1\|451953_452139_-	hypothetical protein	A0A059T5G1	Listeria_phage	4.1e-27	100.0
WP_039378329.1\|452279_452534_-	hypothetical protein	A0A059T6G3	Listeria_phage	3.1e-25	72.0
WP_039378332.1\|452618_453980_-	PcfJ domain-containing protein	A8ATM0	Listeria_phage	1.2e-187	71.3
WP_039378334.1\|453976_454399_-	hypothetical protein	A8ATL9	Listeria_phage	1.1e-43	84.3
WP_172396827.1\|454414_454591_-	hypothetical protein	A8ATL8	Listeria_phage	1.4e-21	93.1
WP_039378336.1\|454550_454928_-	hypothetical protein	A8ATL7	Listeria_phage	1.4e-53	81.0
WP_010990862.1\|454968_455589_-	hypothetical protein	A8ATL6	Listeria_phage	1.0e-98	90.8
WP_003731487.1\|455609_456047_-	RusA family crossover junction endodeoxyribonuclease	A8ATL5	Listeria_phage	1.6e-77	100.0
WP_003731486.1\|456027_456237_-	hypothetical protein	A8ATL4	Listeria_phage	8.2e-32	100.0
WP_003731485.1\|456237_456444_-	hypothetical protein	A8ATL3	Listeria_phage	5.6e-33	100.0
WP_003731483.1\|456621_457437_-	ATP-binding protein	A8ATL1	Listeria_phage	4.8e-144	100.0
WP_003731482.1\|457360_458278_-	DUF4373 domain-containing protein	A8ATL0	Listeria_phage	2.2e-169	100.0
WP_003731481.1\|458289_459027_-	MBL fold metallo-hydrolase	A8ATK9	Listeria_phage	1.7e-135	100.0
WP_003731480.1\|458986_459772_-	phage recombination protein Bet	A8ATK8	Listeria_phage	7.9e-144	100.0
WP_003731479.1\|459772_461716_-	AAA family ATPase	A8ATK7	Listeria_phage	0.0e+00	99.8
WP_003731478.1\|461702_462044_-	hypothetical protein	A8ATK6	Listeria_phage	1.2e-56	100.0
WP_003731477.1\|462061_462289_-	hypothetical protein	A8ATK5	Listeria_phage	1.8e-32	100.0
WP_003731476.1\|462467_462758_-	hypothetical protein	A8ATK4	Listeria_phage	4.6e-49	100.0
WP_003731474.1\|463076_463370_-	helix-turn-helix domain-containing protein	A8ATK2	Listeria_phage	2.3e-48	100.0
WP_003731473.1\|463384_463909_-	hypothetical protein	A8ATK1	Listeria_phage	5.5e-93	100.0
WP_003731472.1\|463985_464171_-	helix-turn-helix transcriptional regulator	A8ATK0	Listeria_phage	1.2e-29	100.0
WP_003731471.1\|464331_464760_+	helix-turn-helix transcriptional regulator	A8ATJ9	Listeria_phage	4.0e-73	100.0
WP_003731470.1\|464776_465196_+	ImmA/IrrE family metallo-endopeptidase	A8ATJ8	Listeria_phage	4.0e-78	100.0
WP_003731469.1\|465243_465636_+	hypothetical protein	A8ATJ7	Listeria_phage	2.3e-59	100.0
WP_003731468.1\|465732_466908_+\|integrase	site-specific integrase	A8ATJ6	Listeria_phage	6.2e-225	100.0
466942:466961	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

8. NZ_APIC01000001

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_APIC01000001_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_APIC01000001_1

26843-26997

Unclear

Consensus_repeat	Method
GTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_APIC01000001_1

>merge|NZ_APIC01000001|1|26843-26997|CRISPRCasFinder
GTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAATTCGAATGAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATCGGTGTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAA

>NZ_APIC01000001|1|1|26843-26997|CRISPRCasFinder
GTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAA	TTCGAATGAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATCGGT
GTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_APIC01000001.1\|WP_003728174.1\|29855_31445_-\|cholesterol-dependent-cytolysin-listeriolysin-O	unknown	unknown	gnl\|CDD\|366559
NZ_APIC01000001.1\|WP_003728173.1\|27988_29521_-\|zinc-metalloproteinase-Mpl	unknown	unknown	gnl\|CDD\|225768
NZ_APIC01000001.1\|WP_003728175.1\|34677_36051_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184643
NZ_APIC01000001.1\|WP_003722726.1\|36437_36746_-\|septation-regulator-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_APIC01000001.1\|WP_172381192.1\|22804_23524_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033
NZ_APIC01000001.1\|WP_003731749.1\|24569_24893_-\|DUF5502-family-protein	unknown	unknown	gnl\|CDD\|340321
NZ_APIC01000001.1\|WP_003728167.1\|15919_19459_-\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_APIC01000001.1\|WP_003725735.1\|23590_23923_+\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_APIC01000001.1\|WP_003725507.1\|37856_39065_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NZ_APIC01000001.1\|WP_003725734.1\|23975_24437_-\|YehR-family-lipoprotein	unknown	unknown	gnl\|CDD\|227145
NZ_APIC01000001.1\|WP_003725738.1\|19572_20133_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_APIC01000001.1\|WP_003722739.1\|21830_22772_+\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NZ_APIC01000001.1\|WP_003731748.1\|24964_25834_-\|phosphatidylcholine-phospholipase-C	unknown	unknown	gnl\|CDD\|214813
NZ_APIC01000001.1\|WP_039377968.1\|39061_39763_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_APIC01000001.1\|WP_003725737.1\|20239_20824_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_APIC01000001.1\|WP_003722729.1\|32913_33627_+\|listeriolysin-O-transcriptional-regulator-PrfA	unknown	unknown	gnl\|CDD\|223736
NZ_APIC01000001.1\|WP_003722740.1\|20913_21537_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_APIC01000001.1\|WP_003722725.1\|36864_37173_-\|septation-regulator-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_APIC01000001.1\|WP_003726703.1\|31687_32641_+\|phosphatidylinositol-specific-phospholipase-C	unknown	unknown	gnl\|CDD\|176497
NZ_APIC01000001.1\|WP_003722728.1\|33670_34627_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929

Protein	Function_ID	Function_description	E-value
NZ_APIC01000001.1\|WP_003728174.1\|29855_31445_-\|cholesterol-dependent-cytolysin-listeriolysin-O	gnl\|CDD\|366559	pfam01289, Thiol_cytolysin, Thiol-activated cytolysin.	7.22171e-179
NZ_APIC01000001.1\|WP_003728173.1\|27988_29521_-\|zinc-metalloproteinase-Mpl	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	8.72102e-140
NZ_APIC01000001.1\|WP_003728175.1\|34677_36051_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_APIC01000001.1\|WP_003722726.1\|36437_36746_-\|septation-regulator-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	5.03804e-54
NZ_APIC01000001.1\|WP_172381192.1\|22804_23524_+\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	3.05419e-22
NZ_APIC01000001.1\|WP_003731749.1\|24569_24893_-\|DUF5502-family-protein	gnl\|CDD\|340321	pfam17606, DUF5502, Family of unknown function (DUF5502). This is a family of unknown function found in Listeria.	1.35733e-43
NZ_APIC01000001.1\|WP_003728167.1\|15919_19459_-\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_APIC01000001.1\|WP_003725735.1\|23590_23923_+\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	8.98192e-61
NZ_APIC01000001.1\|WP_003725507.1\|37856_39065_-\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	5.06393e-62
NZ_APIC01000001.1\|WP_003725734.1\|23975_24437_-\|YehR-family-lipoprotein	gnl\|CDD\|227145	COG4808, COG4808, Uncharacterized protein conserved in bacteria [Function unknown].	1.52192e-59
NZ_APIC01000001.1\|WP_003725738.1\|19572_20133_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	1.72721e-108
NZ_APIC01000001.1\|WP_003722739.1\|21830_22772_+\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NZ_APIC01000001.1\|WP_003731748.1\|24964_25834_-\|phosphatidylcholine-phospholipase-C	gnl\|CDD\|214813	smart00770, Zn_dep_PLPC, Zinc dependent phospholipase C (alpha toxin). This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.	4.429e-86
NZ_APIC01000001.1\|WP_039377968.1\|39061_39763_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.19578e-119
NZ_APIC01000001.1\|WP_003725737.1\|20239_20824_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.9401e-09
NZ_APIC01000001.1\|WP_003722729.1\|32913_33627_+\|listeriolysin-O-transcriptional-regulator-PrfA	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.59942e-12
NZ_APIC01000001.1\|WP_003722740.1\|20913_21537_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.38585e-63
NZ_APIC01000001.1\|WP_003722725.1\|36864_37173_-\|septation-regulator-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	2.92652e-53
NZ_APIC01000001.1\|WP_003726703.1\|31687_32641_+\|phosphatidylinositol-specific-phospholipase-C	gnl\|CDD\|176497	cd00137, PI-PLCc, Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C. This subfamily corresponds to the catalytic domain present in prokaryotic and eukaryotic phosphoinositide-specific phospholipase C (PI-PLC), which is a ubiquitous enzyme catalyzing the cleavage of the sn3-phosphodiester bond in the membrane phosphoinositides (phosphatidylinositol, PI; Phosphatidylinositol-4-phosphate, PIP; phosphatidylinositol 4,5-bisphosphate, PIP2) to yield inositol phosphates (inositol monosphosphate, InsP; inositol diphosphate, InsP2; inositol trisphosphate, InsP3) and diacylglycerol (DAG). The higher eukaryotic PI-PLCs (EC 3.1.4.11) have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. They play a critical role in most signal transduction pathways, controlling numerous cellular events, such as cell growth, proliferation, excitation and secretion. These PI-PLCs strictly require Ca2+ for their catalytic activity. They display a clear preference towards the hydrolysis of the more highly phosphorylated PI-analogues, PIP2 and PIP, to generate two important second messengers, InsP3 and DAG. InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. In contrast, bacterial PI-PLCs contain a single catalytic domain. Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. They participate in Ca2+-independent PI metabolism. They are characterized as phosphatidylinositol-specific phospholipase C (EC 4.6.1.13) that selectively hydrolyze PI, not PIP or PIP2. The TIM-barrel type catalytic domain in bacterial PI-PLCs is very similar to the one in eukaryotic PI-PLCs, in which the catalytic domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. The catalytic mechanism of both prokaryotic and eukaryotic PI-PLCs is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This superfamily also includes a distinctly different type of eukaryotic PLC, glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC), an integral membrane protein characterized in the protozoan parasite Trypanosoma brucei. T. brucei GPI-PLC hydrolyzes the GPI-anchor on the variant specific glycoprotein (VSG), releasing dimyristyl glycerol (DMG), which may facilitate the evasion of the protozoan to the host#s immune system. It does not require Ca2+ for its activity and is more closely related to bacterial PI-PLCs, but not mammalian PI-PLCs.	1.53279e-112
NZ_APIC01000001.1\|WP_003722728.1\|33670_34627_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0

>NZ_APIC01000001.1|WP_003731748.1|24964_25834_-|phosphatidylcholine-phospholipase-C
MKFKKVVLGMCLTASVLVFPVTIKASACCDEYLKPPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVDHMRANLMNELKNFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDKDNTYLPGFANAKITGAKYFNQSVADYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVVKRFCSDDVKEWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFLEFWSKKTNE
>NZ_APIC01000001.1|WP_003731749.1|24569_24893_-|DUF5502-family-protein
MYIKGRLIFFFVMFVIALCSVLILLIIKMSVWKEEPFNLSDAKEIECLGSCKIKNTNQKIHFFSIKKNLFEEEGNMAGILNEHERKGADKSIFIVILDDEKGIANEE
>NZ_APIC01000001.1|WP_003725734.1|23975_24437_-|YehR-family-lipoprotein
MKMLKKGTTVLFVMIMAVMLVACGDKEETKTYSLSQNGVDSKLTYTYKGDKVTKQTAENTMSYASLGVASKEDAEKMLKATSDKFQGIDGLKEKIEYKDDKAIETLEVDYTKISSEDMNKIPGMSSNGDTSKGISMEESAKMLESQGYKEVSK
>NZ_APIC01000001.1|WP_003725735.1|23590_23923_+|putative-heavy-metal-binding-protein
MIVTTSPNIEGKQIIEYKKIVFGEVITGVNFMKDIGAGLRNFFGGRSQGYEDELINAREEAIREMEQRAKDIGANAVIGVDIDYEVLGADNGMLMVTASGTAVVIEAQDY
>NZ_APIC01000001.1|WP_172381192.1|22804_23524_+|DNA-alkylation-repair-protein
MLFLLYLIYSRGVTRTITFDQLNTELQALENPNTIKIFRNHGCPDSLDLYGLKIGDLKKIIRREKLTKNHELAVELIESNNSDLIYLGLLAINPDKITTEQIEKWNIIFHETWSQLTFGLASIVSKRDDALLFAKTWIESDYDLTKSMGWQIYSEHINNLPEAEALLQRAKETLQTETNRTRYSMNGFIITCGIYKDDLHEKAMEAAKSVGKVHVNLGNTACKVPDAISYIEKARNRTK
>NZ_APIC01000001.1|WP_003722739.1|21830_22772_+|L-lactate-dehydrogenase
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
>NZ_APIC01000001.1|WP_003722740.1|20913_21537_-|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MATTLEVQKRETTQHSEVTRLRSEGKVPGIIYGYKSENVPVSVDSLELIKAVRDNGRNAVFSVTVDGKKLNVLLHEYQVDPLKDVLVHVDLLAVDMNEEVETDVRVVLVGDAPGVKAGGVLQQIIHDVKVSATPEKLPETIELDISSLEIGDVLTTNDLPENKDYVVQAEEEETVVTVSAPRAEEEPTTTEAPEPEAVHGKDEEPVE
>NZ_APIC01000001.1|WP_003725737.1|20239_20824_-|GNAT-family-N-acetyltransferase
MLDKSVPHISAIMVNHDATNYPEFHLPEGYSFCFYKDGLEEDWCRLQLETGQVLSMDSIRARFETEFGNEKEKLAKRCVFVEAPNGEIIGTAMLWDGNTFGEMASRIHWVAVLDSHGGKGIAKALLSKILGLNKSSFVYLTTQTGSYQAIYLYQKFGFEKYVGKTPENWKTVNFQEEKEAAWQIIENKIAEHQA
>NZ_APIC01000001.1|WP_003725738.1|19572_20133_-|aminoacyl-tRNA-hydrolase
MKLIAGLGNPGKKYERTRHNVGFMVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVIHYVLGDFPKAEQPDIIAAIQKSADAIEDFAQTPFIEVMNKYNQK
>NZ_APIC01000001.1|WP_003728167.1|15919_19459_-|transcription-repair-coupling-factor
MKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMTHTLNELKENEDKQALVENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYFPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEANHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAFSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVHALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKERASAEN
>NZ_APIC01000001.1|WP_003728173.1|27988_29521_-|zinc-metalloproteinase-Mpl
MKSKLICIIMVIAFQAHFNMAVKADSVGEERLRNNIQAKRNPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYIGNPVKEKEIIINSRTKRLVYNIKLIFAEPEVASWIIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLNHKTDASFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYDYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGREILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGLRDGRIRSIKDPDKYNQAAHMKDYESLPITEEGDWGGVHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
>NZ_APIC01000001.1|WP_003728174.1|29855_31445_-|cholesterol-dependent-cytolysin-listeriolysin-O
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENLISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEINYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNSVDNPIE
>NZ_APIC01000001.1|WP_003726703.1|31687_32641_+|phosphatidylinositol-specific-phospholipase-C
MYKNYLQRTLVLVLCFILCFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTSLAALSIPGTHDTMSYNGDMTWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLKIYHGPIFLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSHKFGMQFGASNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKFN
>NZ_APIC01000001.1|WP_003722729.1|32913_33627_+|listeriolysin-O-transcriptional-regulator-PrfA
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
>NZ_APIC01000001.1|WP_003722728.1|33670_34627_-|ribose-phosphate-diphosphokinase
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
>NZ_APIC01000001.1|WP_003728175.1|34677_36051_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQEEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASRLMQRRINENHMRNGVTLVNPENTYIDIDVKIGQDTVIEPGVMLRGETVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPDDALGIARAKQDNKLGYAKHLNHGK
>NZ_APIC01000001.1|WP_003722726.1|36437_36746_-|septation-regulator-SpoVG
MQVTDVRLRRVETDGRMRAIASITLDEEFVVHDIRVIDGNNGLFVAMPSKRGVDGEFRDIAHPINSDTRAKIQEVVLAEYERVGEEEATAVTEEESESVSAE
>NZ_APIC01000001.1|WP_003722725.1|36864_37173_-|septation-regulator-SpoVG
MEITDVRLRRVETDGRMKAISSITIDGEFVIHDIRVIDGNEGLFVAMPSKRTPDGEFRDIAHPINSGTRAKIQEAVLAAYEVADEPAVNEESSADESIVEEN
>NZ_APIC01000001.1|WP_003725507.1|37856_39065_-|ABC-transporter-permease
MNVLQSMKMAWKQLKASKLRSFLTMLGIIIGVASVILLVSLGNGVTQEVDDQMGDLGSNLITVVNSSVNPNDKYTYDEVMKYQNIDGVKSVSPELSGQVNATFDYKNSSNKVIGTNDQYKAARSLEMKEGRFLLPIDTEYGQKVAVIGSTVASDLFGFGDPIGETIRLNGMPYKVVGVLKEKGASMMGSSDDQIFIPISSAQRLLKDTNVRTIYVETKSAEDVDFVVNTLESRLAIKFGDEKEQEKNASSAQMGPSYQVINQQEILNAFNTISTTLTTALGAIAAISLVVGGIGIMNIMLVSVSERTREIGIRKALGAKKRAILLQFLIESIVISVCGGIIGIIIGVSGALIFGSVAGISSGITAGTIIFSFVFSLCIGVIFGIAPANKASKLRPIDALRSE
>NZ_APIC01000001.1|WP_039377968.1|39061_39763_-|ABC-transporter-ATP-binding-protein
MPKPLIDMKNLTKTYTLGGETFKALDDVTFTVEQGEFLSIVGPSGSGKSTLMNMIGCLDVPDEGSYHLDDVDVFKLSDNKLSEIRNKKIGFIFQQFNLLPKLSAFENVELPLIYAGLSVSAREKAAIECLEKVGLLEKRRNLPTQLSGGQQQRVAIARALAGKPQILLADEPTGALDSKTGFFFKEVMGILQELNRAGNTIVMITHDPTIASYGTRSIRIQDGKLFHEEATQA

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Crispr_ID: NZ_APIC01000001_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_APIC01000001_2

510230-511123

TypeII

II-A,II-B

Consensus_repeat	Method
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	PILER-CR
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	CRISPRCasFinder
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	CRT
CGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACT	PILER-CR

13 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_APIC01000001_2

>merge|NZ_APIC01000001|2|510230-511123|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACGCAATAGACCAGTTAGGTGTCACAGGTGCGGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACGATAGTAGTATAATAACTGTGCTAATATGGGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTCGTACCATAGTATACACATGCAGGGGCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACCATATAGATGTTTCCTTTCTACTCGTATATGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACAAATATTATTCAATGCTGTAACTGTAAAAGGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTACTTTTATTGTCTGCTAAGAATACTACTAGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACATTGTACAAATTCCAAGTAACTCATCATTAGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTTTTCACGTTTGTACTGTCTCTCCTCGTAGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTACGATGTTAAGCGGTGGAGTAGATCAGTAGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTATAGTCTGTTTTTTCGTAAGTGAGCAGCGCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTGGGCAAAATGACCGTAATAAATCCATTCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTAGCACTTATATAGAAGCCCCGCCCCTACGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACAGTGATGGGGAAGAGATTGAACTTATGTTTGTTTTAGAGCTATATTATTCTGAATATCAACACACA

>NZ_APIC01000001|2|1|510230-511057|PILER-CR
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GCAATAGACCAGTTAGGTGTCACAGGTGCG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GATAGTAGTATAATAACTGTGCTAATATGG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTCGTACCATAGTATACACATGCAGGGGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	CATATAGATGTTTCCTTTCTACTCGTATAT
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	AAATATTATTCAATGCTGTAACTGTAAAAG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACTTTTATTGTCTGCTAAGAATACTACTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	ATTGTACAAATTCCAAGTAACTCATCATTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTTTTCACGTTTGTACTGTCTCTCCTCGTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACGATGTTAAGCGGTGGAGTAGATCAGTAGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTATAGTCTGTTTTTTCGTAAGTGAGCAGCGCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTGGGCAAAATGACCGTAATAAATCCATTCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTAGCACTTATATAGAAGCCCCGCCCCTAC
	TAGTCTGTTTTTTCGTAAGTGAGCAGCGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTT	GGGCAAAATGACCGTAATAAATCCATTC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTT	AGCACTTATATAGAAGCCCCGCCCCTAC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC

>NZ_APIC01000001|2|2|510230-511123|CRISPRCasFinder
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GCAATAGACCAGTTAGGTGTCACAGGTGCG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GATAGTAGTATAATAACTGTGCTAATATGG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTCGTACCATAGTATACACATGCAGGGGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	CATATAGATGTTTCCTTTCTACTCGTATAT
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	AAATATTATTCAATGCTGTAACTGTAAAAG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACTTTTATTGTCTGCTAAGAATACTACTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	ATTGTACAAATTCCAAGTAACTCATCATTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTTTTCACGTTTGTACTGTCTCTCCTCGTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACGATGTTAAGCGGTGGAGTAGATCAGTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TATAGTCTGTTTTTTCGTAAGTGAGCAGCGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTGGGCAAAATGACCGTAATAAATCCATTC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTAGCACTTATATAGAAGCCCCGCCCCTAC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	AGTGATGGGGAAGAGATTGAACTTATGTTT
GTTTTAGAGCTATATTATTCTGAATATCAACACACA

>NZ_APIC01000001|2|1|510230-511123|CRT
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GCAATAGACCAGTTAGGTGTCACAGGTGCG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GATAGTAGTATAATAACTGTGCTAATATGG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTCGTACCATAGTATACACATGCAGGGGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	CATATAGATGTTTCCTTTCTACTCGTATAT
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	AAATATTATTCAATGCTGTAACTGTAAAAG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACTTTTATTGTCTGCTAAGAATACTACTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	ATTGTACAAATTCCAAGTAACTCATCATTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTTTTCACGTTTGTACTGTCTCTCCTCGTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACGATGTTAAGCGGTGGAGTAGATCAGTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TATAGTCTGTTTTTTCGTAAGTGAGCAGCGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTGGGCAAAATGACCGTAATAAATCCATTC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTAGCACTTATATAGAAGCCCCGCCCCTAC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	AGTGATGGGGAAGAGATTGAACTTATGTTT
GTTTTAGAGCTATATTATTCTGAATATCAACACACA

>NZ_APIC01000001|2|2|510823-511058|PILER-CR
	GCAATAGACCAGTTAGGTGTCACAGGTGCG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	GATAGTAGTATAATAACTGTGCTAATATGG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTCGTACCATAGTATACACATGCAGGGGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	CATATAGATGTTTCCTTTCTACTCGTATAT
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	AAATATTATTCAATGCTGTAACTGTAAAAG
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACTTTTATTGTCTGCTAAGAATACTACTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	ATTGTACAAATTCCAAGTAACTCATCATTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TTTTTCACGTTTGTACTGTCTCTCCTCGTA
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAAC	TACGATGTTAAGCGGTGGAGTAGATCAGTAGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTATAGTCTGTTTTTTCGTAAGTGAGCAGCGCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTGGGCAAAATGACCGTAATAAATCCATTCGTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTTAGCACTTATATAGAAGCCCCGCCCCTAC
	TAGTCTGTTTTTTCGTAAGTGAGCAGCGC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTT	GGGCAAAATGACCGTAATAAATCCATTC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACTT	AGCACTTATATAGAAGCCCCGCCCCTAC
GTTTTAGAGCTATGTTATTTTGAATGCTACCAAAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_APIC01000001.1\|WP_003730787.1\|509438_510101_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_APIC01000001.1\|WP_003730784.1\|503250_503730_+\|hypothetical-protein	unknown	unknown	unknown
NZ_APIC01000001.1\|WP_003730793.1\|513465_514992_-\|GW-domain-containing-glycosaminoglycan-binding-protein	unknown	unknown	gnl\|CDD\|224619
NZ_APIC01000001.1\|WP_003730786.1\|508244_509111_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_APIC01000001.1\|WP_003723648.1\|509107_509449_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_APIC01000001.1\|WP_003733614.1\|500431_501229_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_APIC01000001.1\|WP_003730794.1\|515260_516287_+\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NZ_APIC01000001.1\|WP_003728531.1\|499562_500429_+\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|237454
NZ_APIC01000001.1\|WP_003730792.1\|512576_513428_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381359
NZ_APIC01000001.1\|WP_003730791.1\|511648_512011_+\|hypothetical-protein	unknown	unknown	unknown
NZ_APIC01000001.1\|WP_003730785.1\|504239_508244_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_APIC01000001.1\|WP_003730783.1\|501234_501981_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_APIC01000001.1\|WP_003727703.1\|502175_502613_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_APIC01000001.1\|WP_003726061.1\|512132_512555_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NZ_APIC01000001.1\|WP_003726075.1\|502634_503027_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888

Protein	Function_ID	Function_description	E-value
NZ_APIC01000001.1\|WP_003730787.1\|509438_510101_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	5.80993e-114
NZ_APIC01000001.1\|WP_003728531.1\|499562_500429_+\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	gnl\|CDD\|237454	PRK13634, cbiO, cobalt transporter ATP-binding subunit; Provisional.	0
NZ_APIC01000001.1\|WP_003730793.1\|513465_514992_-\|GW-domain-containing-glycosaminoglycan-binding-protein	gnl\|CDD\|224619	COG1705, FlgJ, Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion].	9.48061e-69
NZ_APIC01000001.1\|WP_003730786.1\|508244_509111_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.30636e-135
NZ_APIC01000001.1\|WP_003723648.1\|509107_509449_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.60762e-45
NZ_APIC01000001.1\|WP_003733614.1\|500431_501229_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	4.31169e-53
NZ_APIC01000001.1\|WP_003730794.1\|515260_516287_+\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	2.79554e-114
NZ_APIC01000001.1\|WP_003730792.1\|512576_513428_+\|aldo/keto-reductase	gnl\|CDD\|381359	cd19133, AKR_AKR5F1, the AKR5F family of aldo-keto reductase (AKR). Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	7.09169e-171
NZ_APIC01000001.1\|WP_003730785.1\|504239_508244_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_APIC01000001.1\|WP_003730783.1\|501234_501981_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	3.89524e-129
NZ_APIC01000001.1\|WP_003727703.1\|502175_502613_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	2.08607e-102
NZ_APIC01000001.1\|WP_003726061.1\|512132_512555_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	4.55324e-42
NZ_APIC01000001.1\|WP_003726075.1\|502634_503027_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	3.78102e-86

>NZ_APIC01000001.1|WP_003730787.1|509438_510101_+|type-II-A-CRISPR-associated-protein-Csn2
MNFNFKLLDDPIQIEDSTIFVIEDVRVFANVTKFFYQYEETEELTIFDAKHQPLKSSELMLITDVLGHDINSAATLKLIYADLEQQLNEKPEVKSMIDKLTATISELIGYELLEHELDLEEDEITVIELFKALGIKIETKSDTVFEKLIEIVQVYKYLSKKKLLVLINVCSYLTEEELLELRQYISLYQVKVLFIEPRKIKGSPQVTLDSDYFLHVENSV
>NZ_APIC01000001.1|WP_003723648.1|509107_509449_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMLLMFDMPTDTAKERKAYRQFRRFILSEGFIMHQYSVYSKILLNGTASKAMLARLKQQNPKKGLITLLTVTEKQFARMVYLSGEQNKSIGNSDARLVFLGDDADEF
>NZ_APIC01000001.1|WP_003730786.1|508244_509111_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTVVVNSHSKLSYKNQHLVFKSTYQQEMIHLSEIDVLILETTDITLTTMLINCLVAENILILFCDDKRLPIGKVLPFYGRHDSSLQLTKQLEWDAELKAAVWTEIISQKILNQSTYLSMLNYDEKASSLINLHEALAVFDPTNREGHAARIYFNQLFGNDFTREQENDINSGLNYGYTLLLSIFARELVKSGCMTQFGLKHANQFNDFNLASDLMEPFRPLVDQIVYEKRNEDFQVIKRSLFELFTKQFDYNDQHMFLTNIASDYTKKIVKVLNEEREGVPEFRI
>NZ_APIC01000001.1|WP_003730785.1|504239_508244_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKNPYTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTAVDRRMNRTARRRIERRRNRISYLQEIFAVEMANIDANFFCRLNDSFYVDSEKRNSRHPFFATIEEEVAYHKNYRTIYHLREELVNSSEKADLRLVYLALAHIIKYRGNFLIEGALDTKNTSVDEVYKQFIQTYNQVFMSNIEEGALAKVEENTEVASILAGKFTRREKFERILRLYPGEKSTGMFAQFISLIVGNKGNFQKVFNLVEKTDIECAKDSYEEDLEALLAIIGDEYAELFVAAKNTYNAVVLSSIITVTATETNAKLSASMIERFDAHEKELGELKAFIKLHLPKQYQEIFNNAEIDGYAGYIDGKTKQVDFYKYLKTTLENVEGADYFITKIEEENFLRKQRTFDNGVIPHQLHLEELEAILHQQAKYYPFLREGYDKIKSLVTFRIPYFVGPLANGQSEFAWLTRKDDGEIRPWNIEEKVDFGKSAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYIDDQGKTNYFSGREKQQIFNDLFKQKRKVKKKDLELFLRNINHIESPTIEGLEDSFNASYATYHDLLKVGLKQEILDNPLNTEILEDIVKILTVFEDKRMIKEQLEQFSDVLDGVVLKKLERRHYTGWGRLSAKLLVGIRDKQSHLTILDYLMNDDGLNRNLMQLINDSNLSFKSIIEKEQVSTTDKDLQSIVADLAGSPAIKKGILQSLKIVDELVSIMGYPPQTIVVEMARENQTTGKGKNNSKPRYKSLEKAIKDFGSQILKEHPTDNQELKNNRLYLYYLQNGKDIYTGQELDIHNLSNYDIDHIVPQSFITDNSIDNLVLTSSAGNREKGGDVPPLEIVRKRKVFWEKLYQGNLMSKRKFDYLTKAERGGLTEADKARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTMEQVRIVTLKSALVSQFRKQFQLYKVREVNDYHHAHDAYLNGVVANTLLKVYPQLEPEFVYGEYHQFDWFKANKATAKKQFYTNIMLFFAQKERIIDENGEILWDKKYLETIKKVLDYRQINIVKKTEIQKGEFSKATIKPKGNSSKLIPRKENWDPVKYGGLDSPNMAYAVIIEHAKGKKKIVIEKKLIQINIMERKMFEKDEEAFLEEKGYHQPKVLTKLPKYTLYECEKGRRRMLSSANEAQKGNQLVLSNHLVSLLYHAKNCEASDGKSLKYIEAHRETFSELLAQVSEFATKYTLADANLSKINNLFEQNKEGDIKAIAQSFVDLMAFNAMGAPASFKFFEATIDRKRYTNLKELLSSTIIYQSITGLYESRKRLDD
>NZ_APIC01000001.1|WP_003730784.1|503250_503730_+|hypothetical-protein
MKGLIINKMHSGYFTNMSEVFNLLPEEELNCMWLVSSYECNIYPFEQIPFEKEYVWMKGTELKEILNQEEVMFIWGNFTSYPSNTKLKDILKYPIPFADGNSDLWKKDVHLSNPLSNTELISWDGSIFLTLSKNTTLIEGLKDDYPDSEDLSTYNSDID
>NZ_APIC01000001.1|WP_003726075.1|502634_503027_+|30S-ribosomal-protein-S9
MAQVQYYGTGRRKSSVARVRLVPGDGKIVINNRDWEDYIPFAALREVIKQPLVATETLGNYDVLVNVHGGGYTGQAGAIRHGVARALLQVAPEYRPALKSAGLLTRDPRMKERKKYGLKGARRAPQFSKR
>NZ_APIC01000001.1|WP_003727703.1|502175_502613_+|50S-ribosomal-protein-L13
MRTTYMAKPGEVERKWYVIDATGVSLGRLSSEVASILRGKNKPQFTPHIDTGDFVIIINAGKIGLTGKKATDKIYYRHSQYPGGLKSRTAGEMRTNNPEKLLELSIKGMLPKNSLGRQLFKKLHVYGGSEHEHAAQQPEVYELRG
>NZ_APIC01000001.1|WP_003730783.1|501234_501981_+|tRNA-pseudouridine(38-40)-synthase-TruA
MTRYKAIISYDGSGFYGYQVQPNTRTVQAEIEKALTKMHKGKTVRITASGRTDTGVHAKGQVIHFDSELDITAEKFQKALQAMTPFDISFLTVEEVPDDFHARFGTVGKEYRYVVKRTKIFDPFSRNFALHYPYELDISKMKLASKRLIGEHDFTSFCSARTERDSKVRTLYSIDFYEEDDETLVIAFQGNGFLYNMVRILTGTLLDAGQGRISPDDISEALLARDRQKLISKTAPPQGLYLWRVDYE
>NZ_APIC01000001.1|WP_003733614.1|500431_501229_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MMDKMILGRYIPGNSWLHRIDPRAKITAVMAFIAIVFLANNWLTYALMFAYVLYLVLTSKVPFLFFIKGLQPIFWLILITLLLQVFFTKGGTVLVDLGLLQITTLGLTNGAMMFCRFVLIIFMTTLLTLTTSPIELTDGLEKILAPFRLVHLPVHELALMLSISLRFIPTLMDETEKILKAQKARGVEFTSGKWSDRIKAIIPLLVPLFISAFKRAEDLAIAMEARGYRGGKGRTRFRLLRWRFADTLLLISLVVLSGLLFWLRS
>NZ_APIC01000001.1|WP_003728531.1|499562_500429_+|energy-coupling-factor-ABC-transporter-ATP-binding-protein
MEIKLEQLGYCYQKNSPFEKRALLDVNVSFDSGSYSAIIGHTGSGKSTLLQHLNALLMPTEGKITVGDREIVAGVKQKKLRDLRKKVGIVFQFPEAQLFEETVEKDICFGPMNFGVSEEDAKLRAKKVIYEVGLTEEILSRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPTAGLDPHGREEIMEMFYNLHKEKGLTTVLVTHSMEDAARYAEKIVLMKAGTVLQIGTPREIFAKPDELVDLGLSVPDVVRFQGLFERKFDVKLTKTCLTIDELTTEMAPYLAKGGA
>NZ_APIC01000001.1|WP_003730791.1|511648_512011_+|hypothetical-protein
MKKTSIIFIFCALLLTACSTTTKEIPRQTTEATGTIEQVETESILIKNFKIKNDNNTPELSVRFHISEKYHDETGNKIKRTELNKNDNIKIILTKDFPIQETSPAQIDPKYIQKIILLNK
>NZ_APIC01000001.1|WP_003726061.1|512132_512555_+|MerR-family-transcriptional-regulator
MNIKQAADMFGLTVDTLRYYERVGVIPPVHRNESGYRDYKTSDLNWVYLVKNLRNAGLSVESLIEFATLAQLRETQNVEAAQKQVLVDQLKELDEKLAEMKKVRELLVYKIDSYDSHIAQFKAGELNADNVEKLWKRDKF
>NZ_APIC01000001.1|WP_003730792.1|512576_513428_+|aldo/keto-reductase
MKTVKLNNGVEVPILGFGTYQITDAAEAEQAVKDAIKTGYRHIDTAQSYMNEEAVGRGIVASGVDRKELFITTKIWVENVSYKGVMSSFDRSLKRLGLDYIDLLLIHQPFNDVYGAWIAMEELQASGKIRAIGVSNFSPDRVIDLAAFNEVTPQVNQIEVNPFQQQAANLAVLRKEGVAIEAWAPFAEGKNDIFNNPVLTKIGAKYGKSAAQVILRWLVEQDIIVLAKSVKPERMAQNLAIFDFELTEADKGEIASLDQGESQFFSHADPEMVKWMASRKLNV
>NZ_APIC01000001.1|WP_003730793.1|513465_514992_-|GW-domain-containing-glycosaminoglycan-binding-protein
MDRKFIKPGIILLIVAFLVVSINVGAETGGSRTGQVNLTTSQQAFIDEILPAAQDGYRDGKLLTSVTLAQAILESNWGESGLSQNSNNLFGIKGTYKGESVSMGTMEASGSTTANFRVYPSWKESIEDHTALITENARYQDAVGETNYRKALQAIKDGGYATDPDYVSKLVAIIERYNLDKYDVIYDKIESNQSLAAIGTVAENKEQEVIWSAPYNTENANKIGTLENYLGRNLEISWEAKTEKGLWYFIRENNKDIGWINSNALKISYHQKEDENVHLTKYVDDLSAHVYRLPSPEKQFDNGTIAKYDRKALEVDKKITRGGYAWFRISEGEKVIGWVRADKLNDRLYDRITEQTSYDGYALVSKSATDNVWTAPFNTKNAEKLAPLADYDNEKLELVTRAKAGNTLWYQFKVDGKLVGWASEKDLNVFYTPAKEEPVKQVAYVKDPTAKLYNKPVESTSTNPKAVGFYYGKLLAVDKTATILGEDWLHLKDRQNSLGWIKAIDINS
>NZ_APIC01000001.1|WP_003730794.1|515260_516287_+|Mrp/NBP35-family-ATP-binding-protein
MLNEQQITRLLYRLQDPVLEASLEETEGVLEVQVLEETANIKIALADPAVETDHFVHNIEELLTQFGVNEINIELEYLPAAVIDRIFQARDNILSEASETKFLAIASGKGGVGKSTVSANLAIALAQQGKKVGLLDADIYGFSIPVLLGTTESPRKENGQIIPVETHGIQMISMDFFVEQGEPVIWRGPMLGKMIKMFLEEVRWGKLDYLLIDLPPGTGDVALDIHTLIPKCNELIVTTPHYAAASVASRAGYMAAKNNHKIIGVIENMSYLTLADGQVLKVFGQGGGEKVAADLETQLLIQLPIEQPEPNGNGYVSAIFNSSSTSGKAYKTLAEKIIPYLS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_APIC01000001_2	2.11\|510859\|31\|NZ_APIC01000001\|CRISPRCasFinder,CRT	510859-510889	31	NZ_APIC01000007.1	204380-204410	0	1.0
NZ_APIC01000001_2	2.15\|510861\|29\|NZ_APIC01000001\|PILER-CR	510861-510889	29	NZ_APIC01000007.1	204381-204409	0	1.0

1. spacer 2.11|510859|31|NZ_APIC01000001|CRISPRCasFinder,CRT matches to position: 204380-204410, mismatch: 0, identity: 1.0

tatagtctgttttttcgtaagtgagcagcgc	CRISPR spacer
tatagtctgttttttcgtaagtgagcagcgc	Protospacer
*******************************

2. spacer 2.15|510861|29|NZ_APIC01000001|PILER-CR matches to position: 204381-204409, mismatch: 0, identity: 1.0

atagtctgttttttcgtaagtgagcagcg	CRISPR spacer
atagtctgttttttcgtaagtgagcagcg	Protospacer
*****************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	MH299806	Listeria phage LP-KV022, complete genome	52817-52846	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	MN114083	Listeria phage LP-013, complete genome	48513-48542	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	NC_021785	Listeria phage LP-110, complete genome	10535-10564	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	KJ094026	Listeria phage LP-032 contig 3, partial genome	10007-10036	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	MN128593	Listeria phage LP-031, complete genome	47633-47662	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	NC_021787	Listeria phage LP-037, complete genome	5014-5043	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	JX442241	Listeria phage P70, complete genome	54951-54980	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	KJ094020	Listeria phage LP-026, complete genome	31166-31195	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	KJ094021	Listeria phage LP-114, complete genome	38339-38368	0	1.0
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	MN114082	Listeria phage LP-010, complete genome	47798-47827	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MT438761	Listeria virus P61, complete genome	7010-7039	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MT668624	Listeria phage LP-Mix_6.2, complete genome	131100-131129	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	KJ668718	Listeria phage LMTA-34 hypothetical proteins and DNA modification protein genes, complete cds	1258-1287	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MT178766	Listeria virus P100plus, complete genome	96120-96149	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	NC_047872	Listeria phage LMTA-94, complete genome	2498-2527	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MT178767	Listeria virus P200, complete genome	96121-96150	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	KJ591605	Listeria phage LMTA-57, complete genome	12879-12908	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MN128594	Listeria phage LP-066, complete genome	131590-131619	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	NC_042048	Listeria phage LMTA-34, complete genome	8562-8591	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MK792752	UNVERIFIED: Listera phage vB-LmoM-SH3-3, complete genome	6613-6642	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	NC_041862	Listeria phage LP-064, complete genome	3914-3943	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	KJ094030	Listeria phage LP-083-2, complete genome	981-1010	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	JX126918	Listeria phage LP-125, complete genome	3914-3943	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	NC_024360	Listeria phage LMSP-25, complete genome	8562-8591	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	JQ797329	Listeria phage vB_LmoM_AG20, complete genome	129717-129746	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	KJ094031	Listeria phage LP-124, complete genome	98866-98895	0	1.0
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	DQ003638	Listeria phage A511, complete genome	129539-129568	0	1.0
NZ_APIC01000001_2	2.12\|510926\|30\|NZ_APIC01000001\|CRISPRCasFinder,CRT	510926-510955	30	KJ094023	Listeria phage LP-101, complete genome	13151-13180	0	1.0
NZ_APIC01000001_2	2.16\|510928\|28\|NZ_APIC01000001\|PILER-CR	510928-510955	28	KJ094023	Listeria phage LP-101, complete genome	13152-13179	0	1.0
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	MN172529	Listeria phage LP-039, complete genome	129892-129921	1	0.967
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	NC_025440	Listeria phage WIL-1, complete genome	38247-38276	1	0.967
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	DQ003638	Listeria phage A511, complete genome	129021-129050	1	0.967
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	KJ591604	Listeria phage LMTA-148, complete genome	6287-6316	1	0.967
NZ_APIC01000001_2	2.6\|510595\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510595-510624	30	KJ094033	Listeria phage LP-048, complete genome	132349-132378	1	0.967
NZ_APIC01000001_2	2.12\|510926\|30\|NZ_APIC01000001\|CRISPRCasFinder,CRT	510926-510955	30	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	222678-222707	1	0.967
NZ_APIC01000001_2	2.16\|510928\|28\|NZ_APIC01000001\|PILER-CR	510928-510955	28	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	222679-222706	1	0.964
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	MN904502	Listeria phage LP-018, complete genome	47792-47821	2	0.933
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	KJ668718	Listeria phage LMTA-34 hypothetical proteins and DNA modification protein genes, complete cds	1776-1805	2	0.933
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	MT178766	Listeria virus P100plus, complete genome	96638-96667	2	0.933
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	NC_025440	Listeria phage WIL-1, complete genome	37729-37758	2	0.933
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	MT178767	Listeria virus P200, complete genome	96639-96668	2	0.933
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	KJ591605	Listeria phage LMTA-57, complete genome	12361-12390	2	0.933
NZ_APIC01000001_2	2.2\|510332\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510332-510361	30	JB137888	Sequence 7 from Patent WO2012159774	340-369	3	0.9
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	MK792752	UNVERIFIED: Listera phage vB-LmoM-SH3-3, complete genome	6095-6124	3	0.9
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	NC_047872	Listeria phage LMTA-94, complete genome	1980-2009	3	0.9
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	NC_042048	Listeria phage LMTA-34, complete genome	9080-9109	3	0.9
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	NC_024360	Listeria phage LMSP-25, complete genome	9080-9109	3	0.9
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	MT668624	Listeria phage LP-Mix_6.2, complete genome	131618-131647	4	0.867
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	MN128594	Listeria phage LP-066, complete genome	132108-132137	4	0.867
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	NC_041862	Listeria phage LP-064, complete genome	4432-4461	4	0.867
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	KJ094030	Listeria phage LP-083-2, complete genome	1499-1528	4	0.867
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	JX126918	Listeria phage LP-125, complete genome	4432-4461	4	0.867
NZ_APIC01000001_2	2.7\|510661\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510661-510690	30	KJ094031	Listeria phage LP-124, complete genome	99384-99413	4	0.867
NZ_APIC01000001_2	2.16\|510928\|28\|NZ_APIC01000001\|PILER-CR	510928-510955	28	NZ_LR136959	Alteromonas sp. 76-1 plasmid pAlt76, complete sequence	31735-31762	7	0.75
NZ_APIC01000001_2	2.1\|510266\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510266-510295	30	NZ_CP040765	Paracoccus sp. 2251 plasmid unnamed1, complete sequence	223230-223259	8	0.733
NZ_APIC01000001_2	2.5\|510529\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510529-510558	30	NC_012970	Methylovorus glucosetrophus SIP3-4 plasmid pMsip01, complete sequence	63330-63359	8	0.733
NZ_APIC01000001_2	2.5\|510529\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510529-510558	30	MN552143	Lactococcus phage P1046, complete genome	19997-20026	8	0.733
NZ_APIC01000001_2	2.5\|510529\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510529-510558	30	NC_010576	Lactococcus phage 1706, complete genome	21200-21229	8	0.733
NZ_APIC01000001_2	2.5\|510529\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510529-510558	30	MK779875	Lactococcus phage CHPC971, complete genome	20962-20991	8	0.733
NZ_APIC01000001_2	2.8\|510727\|30\|NZ_APIC01000001\|PILER-CR,CRISPRCasFinder,CRT	510727-510756	30	MN035989	Leviviridae sp. isolate H3_Bulk_41_scaffold_462 RNA-dependent RNA polymerase (H3Bulk41462_000001), hypothetical protein (H3Bulk41462_000002), hypothetical protein (H3Bulk41462_000003), and hypothetical protein (H3Bulk41462_000004) genes, complete cds	382-411	8	0.733
NZ_APIC01000001_2	2.14\|511058\|30\|NZ_APIC01000001\|CRISPRCasFinder,CRT	511058-511087	30	MN855765	Myoviridae sp. isolate 14, complete genome	24949-24978	8	0.733
NZ_APIC01000001_2	2.12\|510926\|30\|NZ_APIC01000001\|CRISPRCasFinder,CRT	510926-510955	30	NZ_LR136959	Alteromonas sp. 76-1 plasmid pAlt76, complete sequence	31734-31763	9	0.7

1. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MH299806 (Listeria phage LP-KV022, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

2. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN114083 (Listeria phage LP-013, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

3. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_021785 (Listeria phage LP-110, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

4. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094026 (Listeria phage LP-032 contig 3, partial genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

5. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN128593 (Listeria phage LP-031, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

6. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_021787 (Listeria phage LP-037, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

7. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to JX442241 (Listeria phage P70, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

8. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094020 (Listeria phage LP-026, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

9. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094021 (Listeria phage LP-114, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

10. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN114082 (Listeria phage LP-010, complete genome) position: , mismatch: 0, identity: 1.0

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaatatgg	Protospacer
******************************

11. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT438761 (Listeria virus P61, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

12. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT668624 (Listeria phage LP-Mix_6.2, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

13. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ668718 (Listeria phage LMTA-34 hypothetical proteins and DNA modification protein genes, complete cds) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

14. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT178766 (Listeria virus P100plus, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

15. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_047872 (Listeria phage LMTA-94, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

16. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT178767 (Listeria virus P200, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

17. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ591605 (Listeria phage LMTA-57, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

18. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN128594 (Listeria phage LP-066, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

19. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_042048 (Listeria phage LMTA-34, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

20. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MK792752 (UNVERIFIED: Listera phage vB-LmoM-SH3-3, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

21. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_041862 (Listeria phage LP-064, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

22. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094030 (Listeria phage LP-083-2, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

23. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to JX126918 (Listeria phage LP-125, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

24. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_024360 (Listeria phage LMSP-25, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

25. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to JQ797329 (Listeria phage vB_LmoM_AG20, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

26. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094031 (Listeria phage LP-124, complete genome) position: , mismatch: 0, identity: 1.0

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttattgtctgctaagaatactacta	Protospacer
******************************

27. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to DQ003638 (Listeria phage A511, complete genome) position: , mismatch: 0, identity: 1.0

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaattccaagtaactcatcatta	Protospacer
******************************

28. spacer 2.12|510926|30|NZ_APIC01000001|CRISPRCasFinder,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

ttgggcaaaatgaccgtaataaatccattc	CRISPR spacer
ttgggcaaaatgaccgtaataaatccattc	Protospacer
******************************

29. spacer 2.16|510928|28|NZ_APIC01000001|PILER-CR matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

tgggcaaaatgaccgtaataaatccatt	CRISPR spacer
tgggcaaaatgaccgtaataaatccatt	Protospacer
****************************

30. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN172529 (Listeria phage LP-039, complete genome) position: , mismatch: 1, identity: 0.967

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttgttgtctgctaagaatactacta	Protospacer
*******.**********************

31. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_025440 (Listeria phage WIL-1, complete genome) position: , mismatch: 1, identity: 0.967

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttgttgtctgctaagaatactacta	Protospacer
*******.**********************

32. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to DQ003638 (Listeria phage A511, complete genome) position: , mismatch: 1, identity: 0.967

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttgttgtctgctaagaatactacta	Protospacer
*******.**********************

33. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ591604 (Listeria phage LMTA-148, complete genome) position: , mismatch: 1, identity: 0.967

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttgttgtctgctaagaatactacta	Protospacer
*******.**********************

34. spacer 2.6|510595|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094033 (Listeria phage LP-048, complete genome) position: , mismatch: 1, identity: 0.967

tacttttattgtctgctaagaatactacta	CRISPR spacer
tacttttgttgtctgctaagaatactacta	Protospacer
*******.**********************

35. spacer 2.12|510926|30|NZ_APIC01000001|CRISPRCasFinder,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 1, identity: 0.967

ttgggcaaaatgaccgtaataaatccattc	CRISPR spacer
ttgagcaaaatgaccgtaataaatccattc	Protospacer
***.**************************

36. spacer 2.16|510928|28|NZ_APIC01000001|PILER-CR matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 1, identity: 0.964

tgggcaaaatgaccgtaataaatccatt	CRISPR spacer
tgagcaaaatgaccgtaataaatccatt	Protospacer
**.*************************

37. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN904502 (Listeria phage LP-018, complete genome) position: , mismatch: 2, identity: 0.933

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataactgtgctaaaatag	Protospacer
************************* **.*

38. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ668718 (Listeria phage LMTA-34 hypothetical proteins and DNA modification protein genes, complete cds) position: , mismatch: 2, identity: 0.933

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaattccaagtaactcatcctca	Protospacer
************************** *.*

39. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT178766 (Listeria virus P100plus, complete genome) position: , mismatch: 2, identity: 0.933

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcatcatca	Protospacer
***********.****************.*

40. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_025440 (Listeria phage WIL-1, complete genome) position: , mismatch: 2, identity: 0.933

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcatcatca	Protospacer
***********.****************.*

41. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT178767 (Listeria virus P200, complete genome) position: , mismatch: 2, identity: 0.933

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcatcatca	Protospacer
***********.****************.*

42. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ591605 (Listeria phage LMTA-57, complete genome) position: , mismatch: 2, identity: 0.933

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcatcatca	Protospacer
***********.****************.*

43. spacer 2.2|510332|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to JB137888 (Sequence 7 from Patent WO2012159774) position: , mismatch: 3, identity: 0.9

gatagtagtataataactgtgctaatatgg	CRISPR spacer
gatagtagtataataacagtactaatatag	Protospacer
***************** **.*******.*

44. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MK792752 (UNVERIFIED: Listera phage vB-LmoM-SH3-3, complete genome) position: , mismatch: 3, identity: 0.9

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcatcacca	Protospacer
***********.***************..*

45. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_047872 (Listeria phage LMTA-94, complete genome) position: , mismatch: 3, identity: 0.9

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcgtcatca	Protospacer
***********.***********.****.*

46. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_042048 (Listeria phage LMTA-34, complete genome) position: , mismatch: 3, identity: 0.9

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcgtcatca	Protospacer
***********.***********.****.*

47. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_024360 (Listeria phage LMSP-25, complete genome) position: , mismatch: 3, identity: 0.9

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcgtcatca	Protospacer
***********.***********.****.*

48. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MT668624 (Listeria phage LP-Mix_6.2, complete genome) position: , mismatch: 4, identity: 0.867

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcattgtca	Protospacer
***********.*************..*.*

49. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN128594 (Listeria phage LP-066, complete genome) position: , mismatch: 4, identity: 0.867

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcattgtca	Protospacer
***********.*************..*.*

50. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_041862 (Listeria phage LP-064, complete genome) position: , mismatch: 4, identity: 0.867

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcattgtca	Protospacer
***********.*************..*.*

51. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094030 (Listeria phage LP-083-2, complete genome) position: , mismatch: 4, identity: 0.867

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcattgtca	Protospacer
***********.*************..*.*

52. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to JX126918 (Listeria phage LP-125, complete genome) position: , mismatch: 4, identity: 0.867

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcattgtca	Protospacer
***********.*************..*.*

53. spacer 2.7|510661|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to KJ094031 (Listeria phage LP-124, complete genome) position: , mismatch: 4, identity: 0.867

attgtacaaattccaagtaactcatcatta	CRISPR spacer
attgtacaaatcccaagtaactcattgtca	Protospacer
***********.*************..*.*

54. spacer 2.16|510928|28|NZ_APIC01000001|PILER-CR matches to NZ_LR136959 (Alteromonas sp. 76-1 plasmid pAlt76, complete sequence) position: , mismatch: 7, identity: 0.75

tgggcaaaatgaccgtaataaatccatt	CRISPR spacer
ctttcaaaatgatcgtaataaatcaata	Protospacer
.   ********.*********** **

55. spacer 2.1|510266|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040765 (Paracoccus sp. 2251 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gcaatagaccagttaggtgtcacaggtgcg	CRISPR spacer
gccatagaccagttcggtgtcactcagccc	Protospacer
** *********** ********  .  *

56. spacer 2.5|510529|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_012970 (Methylovorus glucosetrophus SIP3-4 plasmid pMsip01, complete sequence) position: , mismatch: 8, identity: 0.733

aaatattattcaatgctgtaactgtaaaag	CRISPR spacer
taatatttttcaatgctgcaactgctgtcg	Protospacer
 ****** **********.*****. .  *

57. spacer 2.5|510529|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN552143 (Lactococcus phage P1046, complete genome) position: , mismatch: 8, identity: 0.733

aaatattattcaatgctgtaactgtaaaag	CRISPR spacer
ctaatctattcaatgcagtaactgtaactg	Protospacer
  *  .********** **********  *

58. spacer 2.5|510529|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to NC_010576 (Lactococcus phage 1706, complete genome) position: , mismatch: 8, identity: 0.733

aaatattattcaatgctgtaactgtaaaag	CRISPR spacer
ctaatctattcaatgcagtaactgtaactg	Protospacer
  *  .********** **********  *

59. spacer 2.5|510529|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MK779875 (Lactococcus phage CHPC971, complete genome) position: , mismatch: 8, identity: 0.733

aaatattattcaatgctgtaactgtaaaag	CRISPR spacer
ctaatctattcaatgcagtaactgtaactg	Protospacer
  *  .********** **********  *

60. spacer 2.8|510727|30|NZ_APIC01000001|PILER-CR,CRISPRCasFinder,CRT matches to MN035989 (Leviviridae sp. isolate H3_Bulk_41_scaffold_462 RNA-dependent RNA polymerase (H3Bulk41462_000001), hypothetical protein (H3Bulk41462_000002), hypothetical protein (H3Bulk41462_000003), and hypothetical protein (H3Bulk41462_000004) genes, complete cds) position: , mismatch: 8, identity: 0.733

------tttttcacgtttgtactgtctctcctcgta	CRISPR spacer
gggaaat------cgtttctactgtctctcttcgta	Protospacer
      *      ***** ***********.*****

61. spacer 2.14|511058|30|NZ_APIC01000001|CRISPRCasFinder,CRT matches to MN855765 (Myoviridae sp. isolate 14, complete genome) position: , mismatch: 8, identity: 0.733

agtgatggggaagagattgaacttatgttt	CRISPR spacer
gctgatgggaaagaggttgaacttaaaggt	Protospacer
. *******.*****.********* .  *

62. spacer 2.12|510926|30|NZ_APIC01000001|CRISPRCasFinder,CRT matches to NZ_LR136959 (Alteromonas sp. 76-1 plasmid pAlt76, complete sequence) position: , mismatch: 9, identity: 0.7

ttgggcaaaatgaccgtaataaatccattc	CRISPR spacer
gctttcaaaatgatcgtaataaatcaatag	Protospacer
 .   ********.*********** **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

97145 : 107874

Listeria_phage(40.0%)

tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003724957.1\|97145_97874_-	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	1.3e-34	42.5
WP_003728205.1\|97854_98277_-\|holin	holin family protein	Q2I8E7	Bacillus_phage	8.6e-28	46.3
WP_003728206.1\|98295_98832_-	hypothetical protein	NA	NA	NA	NA
WP_003728207.1\|98828_99308_-	hypothetical protein	NA	NA	NA	NA
WP_003731180.1\|99322_99898_-	hypothetical protein	NA	NA	NA	NA
WP_003721751.1\|99912_100212_-	hypothetical protein	NA	NA	NA	NA
WP_003728209.1\|100201_101338_-\|tail	phage tail protein	A0A0B5D0G3	Listeria_phage	2.2e-46	33.8
WP_003731179.1\|101347_102166_-\|tail	phage tail family protein	Q9T1A6	Listeria_phage	2.2e-43	35.5
WP_003731178.1\|102162_104031_-	membrane protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_003740367.1\|104017_104422_-	hypothetical protein	A0A097PAX1	Streptococcus_pyogenes_phage	8.2e-20	43.7
WP_003721745.1\|104463_104766_-	hypothetical protein	NA	NA	NA	NA
WP_003721744.1\|104813_105326_-\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_003728212.1\|105338_105728_-	DUF5072 family protein	NA	NA	NA	NA
WP_003731177.1\|106007_106424_-	hypothetical protein	NA	NA	NA	NA
WP_003724946.1\|106435_106864_-	hypothetical protein	A8ATZ8	Listeria_phage	3.9e-12	45.7
WP_003721740.1\|107080_107416_+	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003728215.1\|107421_107874_+	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

9. NZ_APIC01000009

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

5808 : 14103

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003729814.1\|5808_7101_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.5e-17	33.0
WP_003731571.1\|7181_7895_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	3.9e-41	38.3
WP_003722248.1\|7906_8152_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_039378974.1\|8155_8839_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003731570.1\|8831_11051_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	6.5e-159	40.8
WP_003722245.1\|11035_12463_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-53	34.6
WP_039378977.1\|12481_13540_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.7e-62	44.3
WP_003731569.1\|13536_14103_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	2.8e-26	38.5

DBSCAN-SWA_2

95222 : 126142

Erysipelothrix_phage(70.37%)

capsid,protease,terminase,tail,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010821424.1\|95222_95537_+	hypothetical protein	A0A2K5B2A7	Erysipelothrix_phage	6.6e-09	41.5
WP_003731108.1\|95537_96680_+	DUF2800 domain-containing protein	M1Q218	Streptococcus_phage	1.5e-122	57.8
WP_003731109.1\|96681_97224_+	DUF2815 family protein	A0A2K5B2A9	Erysipelothrix_phage	8.9e-78	77.2
WP_003731110.1\|97284_99222_+	DNA polymerase	A0A2K5B2B0	Erysipelothrix_phage	7.7e-265	68.6
WP_014929981.1\|99432_100203_+	phage antirepressor KilAC domain-containing protein	A0A1Q1PVU2	Staphylococcus_phage	2.7e-64	50.8
WP_014929980.1\|100195_100540_+	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	4.1e-28	51.4
WP_003731113.1\|100532_102776_+	primase C-terminal domain-containing protein	A0A1B0RXC5	Streptococcus_phage	4.8e-210	49.7
WP_003731114.1\|102913_103123_+	hypothetical protein	NA	NA	NA	NA
WP_003731115.1\|103119_103404_+	VRR-NUC domain-containing protein	A0A2K5B272	Erysipelothrix_phage	3.5e-25	60.2
WP_014929979.1\|103403_104756_+	DEAD/DEAH box helicase	A0A2K5B273	Erysipelothrix_phage	6.8e-159	69.0
WP_003731117.1\|104752_105181_+	DUF1492 domain-containing protein	NA	NA	NA	NA
WP_031641526.1\|105348_105714_+	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	1.4e-31	56.9
WP_031641527.1\|105846_106425_+\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	1.2e-53	52.8
WP_014929977.1\|106429_107212_+	S-adenosylmethionine synthetase	NA	NA	NA	NA
WP_100066220.1\|107436_107814_+	HNH endonuclease	A0A0B5HE03	Vibrio_phage	4.5e-12	38.8
WP_003731123.1\|107803_109054_+	site-specific DNA-methyltransferase	A0A2I4R670	Erysipelothrix_phage	7.4e-144	62.0
WP_003731124.1\|109142_109532_+	DUF4314 domain-containing protein	E4ZFL7	Streptococcus_phage	3.1e-16	71.0
WP_003731125.1\|109534_109729_+	hypothetical protein	NA	NA	NA	NA
WP_003731126.1\|109703_109901_+	DUF5049 domain-containing protein	NA	NA	NA	NA
WP_003731127.1\|109890_110115_+	hypothetical protein	A0A2K5B284	Erysipelothrix_phage	2.0e-15	48.6
WP_088518322.1\|110175_111768_+\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	7.2e-269	84.8
WP_100066221.1\|111899_112160_+	hypothetical protein	NA	NA	NA	NA
WP_003731131.1\|113464_114238_+\|protease	Clp protease ClpP	M1PLE5	Streptococcus_phage	2.0e-62	55.7
WP_003731132.1\|114241_115459_+\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	1.1e-102	48.0
WP_003731133.1\|115469_115781_+\|head,tail	phage gp6-like head-tail connector protein	A0A2K5B290	Erysipelothrix_phage	2.2e-36	74.0
WP_003731134.1\|115777_116116_+\|head,tail	head-tail adaptor protein	A0A2K5B291	Erysipelothrix_phage	1.7e-23	54.7
WP_003731135.1\|116108_116540_+	HK97 gp10 family phage protein	A0A2K5B292	Erysipelothrix_phage	7.6e-40	59.4
WP_029645088.1\|116566_116875_+	hypothetical protein	A0A2K5B293	Erysipelothrix_phage	1.5e-26	52.0
WP_003731136.1\|116876_117467_+\|tail	phage tail protein	A0A2K5B294	Erysipelothrix_phage	4.1e-76	72.2
WP_003731137.1\|117476_117860_+	hypothetical protein	A0A2K5B295	Erysipelothrix_phage	5.4e-37	64.2
WP_003731138.1\|118111_118756_+	DUF1643 domain-containing protein	NA	NA	NA	NA
WP_003731139.1\|118823_121385_+	hypothetical protein	A0A2K5B297	Erysipelothrix_phage	3.9e-83	74.1
WP_003731140.1\|121400_122093_+	hypothetical protein	A0A1B1P761	Bacillus_phage	5.4e-27	33.2
WP_003731141.1\|122077_126142_+\|tail	phage tail protein	A0A1B1P770	Bacillus_phage	8.7e-85	41.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

10. NZ_APIC01000015

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

31112 : 34374

Listeria_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003731277.1\|31112_31346_+	hypothetical protein	A8ATW9	Listeria_phage	4.3e-13	100.0
WP_003731276.1\|31377_31629_+	hypothetical protein	A8ATW8	Listeria_phage	2.0e-40	100.0
WP_003722518.1\|31629_32079_+	anti-CRISPR protein AcrIIA1	A8ATW7	Listeria_phage	2.4e-76	100.0
WP_003733661.1\|32103_32601_+	AP2 domain-containing protein	A8ATW6	Listeria_phage	3.8e-91	100.0
WP_003722520.1\|32875_33649_+	DUF3825 domain-containing protein	A8ATW5	Listeria_phage	9.5e-150	100.0
WP_039379331.1\|33689_34374_-	M15 family metallopeptidase	A0A059T7Y8	Listeria_phage	3.0e-107	93.9

Anti-CRISPR protein detection

Acr_ID: NZ_APIC01000015.1|WP_003731276.1|31377_31629_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_APIC01000015.1|WP_003731276.1|31377_31629_+|hypothetical-protein

31377_31629_+

83 aa aa

AcrIIA12

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3641\|WP_003731276.1\|AcrIIA12\|II-A\|Verified\|Listeria-monocytogenes	1.0	1	1.0

31112-34374