CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
MIDB01000009	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_27, whole genome shotgun sequence	0 crisprs	cas3	0	0	0	0
MIDB01000010	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_2849, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000020	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_92, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
MIDB01000002	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_118, whole genome shotgun sequence	0 crisprs	DEDDh	0	0	0	0
MIDB01000012	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_43, whole genome shotgun sequence	0 crisprs	DEDDh	0	0	0	0
MIDB01000015	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_6494, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000018	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_88, whole genome shotgun sequence	0 crisprs	csa3	0	0	0	0
MIDB01000003	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_1318, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
MIDB01000004	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_1771, whole genome shotgun sequence	0 crisprs	NA	0	0	0	1
MIDB01000014	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_6488, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000016	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_7, whole genome shotgun sequence	0 crisprs	DEDDh,csa3	0	0	0	0
MIDB01000008	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_2518, whole genome shotgun sequence	0 crisprs	NA	0	0	1	1
MIDB01000006	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_239, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000005	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_23, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000017	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_7870, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000013	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_54, whole genome shotgun sequence	0 crisprs	NA	0	0	1	1
MIDB01000007	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_24, whole genome shotgun sequence	0 crisprs	NA	0	0	1	1
MIDB01000001	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_11062, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
MIDB01000019	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_9, whole genome shotgun sequence	0 crisprs	csa3	0	0	0	1
MIDB01000011	Tenericutes bacterium RIFOXYA2_FULL_36_32 rifoxya2_full_scaffold_4, whole genome shotgun sequence	0 crisprs	DinG	0	0	0	0

1. MIDB01000020

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	45949 : 52218	8	Streptococcus_phage(33.33%)	tRNA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>MIDB01000020|45949:52218|DBSCAN-SWA
CTCACCTCTTCTTCTCTAGTATATAAAACAAATGGTCCAATGCTAAGTCTAAGTTTATATTATAGGATTGTTGTTGTAAAACAGTCTGAATTTGCTCAATTAAATCATTAACTTCTAAAACTTGCATCCGATCGCTTTGAATTTGAATCACATCTTTTAAAAATTTATAAACAAGTGGTTGATGTGTGCGGTAGTGAACGAAATCTAAGAAATAGAGCAATAAAAGTTCTAAGAAATCCATGAAGAAATCACGATCTTGCATGAGAAAACCTGATTTTTGTGCAAAATGTATGGGATATGAAACATCTTTTTTATCCCAAAGTCGTGCGATCTCTTCAATAAGAGCGATCAAATCGAGAAAATTAGGGTTTTCTGCAAGGAGTGTTGCTTCTTCGATATTTTTAGTGACGTAAGGTGCGAGTGTTGCAACCTTTTCATCAACCCCTAGTTTAATTAACTCTTCTTCTAAATCGAGTTCATCAATACTCTTTAATGTCAGTATTTGACTTCGTGATTGTATCGTACGTAGTACATCTTCTTTATCTTCAGCAAGTAAGAACCCAAATACCTGTTGACTTTGTGGCTCTTCCATAAACTTTAATAACGAGTTTGCTGCTGCAATGCTGATTTTTTCAATGCCCTTAATGACATAAATACGTGGTCCACTAACAAGTGCTGTTTTAGAAAACTCATTTTGAAGTGCCAAAATTTGTTCTTTTTTAATGGATAATCCATCCGGTTCAATCACACTCATATTTTGAACTTTACGTTCTTTGATTTGTAATTTTAAATGAGGGGATTCAGCTTTCCCCTGATTTAAAATCAAATAAGCAACATCATCAACAAGTTGTGACTTACCAGATCCTTTAGGACCGACAATCAAGTAAAGGTGCGCTAATCTATTTTTTTGTATGGTTTGTTTAAAAAAATAGTATGCTCTTTTCATAAGTGCTTTTCAATCTCTTCGAGTATTTGTTCTTGAATTTTTTCGATTGTTTGAGAACCATCAATCACAATAATACGTTCTTGATAACGTTTAGCAACTTCTAAATAGCCTTCTCTCACTTTCGTATGAAAATCAAAAGCTTCTTGATCAAGACGATCATACTTATCGCGATGTGCAATGCGTGATAAACCAATTTTAGGATCTAAATCGATGTAAAACGTTAGATTCGGTAAATTTTCAACCGCATAACGATTGATTGATAAGACAAAATCAAAACCTAAGTTTCTTGCATATGCTTGATAAGCTAAACTCGAATCTATATAACGATCACATAAAACGATTTTTTGTGCACGAAGTGCAGGTAAAATCACTTCATCTAAATGTTGCGCTCTTGATGCTGCTAAAAGAAGTGCTTCCGTGTAAGGTGTTACACCTTGATATTTCGGATTTAAAATGATGTCACGAATGGCTTCTGCAATGTTAGACCCACCAGGTTCACGTGTTGTTACGACGTTATACTGATTTCTTAACACGGCTGCAATGCCTTGAATTAATGTCGTTTTACCGGTGCCTTCGCCACCTTCAAAGGTGATAAACATAGGTGCACACTCCTTTACGTTCTTTTTTTATAATTGATTTTAACTAAAAATAGTCCTCTTGATTCAGCAGTTTTACCTGCTAAATGACGATCTTTAGTTTCTAAAATAGTGCTAATAATGCCTGGTTCTTTACGGTGAAGTCCTATTTGAATGAGTGTTCCCATCATGGATCTCACCATATATTTTAAAAATGAATTTCCATGAAAGGTAAATACATAATGTTTAGATGTTTCTTTGAGCGTGACTTCATGTATTGTTTTAACGGTAGGTTTTCCTGGAACTAACTGACAAAAACCTCTAAAATCATGCGTACCCACAAAAAGTGGTAATGCTTCTTTGATGGGATTGATATCTAAATTTCTAATGTAGACTTCATAGTTTTTTGTAAAAGGTGTTTCAGGATTTTTCGCAATCACATAGCGATAGACTTTAGAAGTTGCACTATGTCTTGCATGGAAATCTGAAGCAACTTTTTTTACACTCTTTAGTCTGATATCTAAAGGAAGACGGTCGTTAACCCCTCTAACCCAAATATCTGAAGGTAGATCAATTTTACTATCAAAATGAAAGACTTGACCAAGTGCATGGACACCTTTATCCGTTCTTCCTGCACTATGAATCTTGATCTCTGTTTGTGTCATTAGTCGAAGTGCTTTTTCAATCACTTCTTGAATACCCAAACCGTTATGTTGGCTTTGAAAACCGATGTAATTTGAACCATCATAACTCACAACTGCTTTATATCTCATCCGATAATCCTCATCATAATGATGATTGCTAAAAATAAAGTTACAACAAACACAGCCATGATATCTTTAAAACCAATCTTATATTGATCAATTTTTGTACGCTTCGCGCCAATCACATAACCTCTTACTTCCATGGCATTCCCTAAATCTTCAGCTCGTTTAAAACTGATGACGAAAACAGGAATGAGAAGTGAAATGATTTGAACAACTTTATCTTTAAATTTACTTTCTTTGAAATCTACTCCACGTGATGCTTGTGCCTTCATAATCTTTTCGGTTTCACCCAAAAGTGTTGGAATGTAGCGAAGCGTTAACGATAACATCATCGCAATCACATCAACAGGGACTTTAATCCATTTAAGTGGTTTTAAAAGTGATTCAATCGCGTAATTTAAATCAGTTGTCATCGTTGTAAATGTGAGTAACGACGTCATGATAATCACATTGGTAATACGTATGAATATAAAGCCTGCACGTAGTAAGCCTTGATCATAAACGTCAAGTTTATATGTATATAAGCTAATGTATGGTAATACGGCTTGTACAAAAAAGATTAACCCGACAATGAGTAAAAAATATAATATTCTAAACTTAATGTATTTTTTGGACCAATTGTAAAAGACAAATAAAATAAGAATTGCTCCAATGCTTGCAACCGATAAATAAAAATCAAAAGAAACAAGCAATTCTCCTTCAGTAATAAAGAATAACTGAATAAAGAAGGTAAATGTTAATAGAAATACAATCGGACGTAGTCCATTGATCACTTTTTTAATTGGAATACCCGCACTTGCAGTTAAGATCATCATGCCCAAAAAGATAGCAACCATGGTGATAATCGGAATTAAATCTGCAGAAATCGGAATGATAAATGTTCCAACCAATAAAATCACAAGTGAAAACAACTTTATTCTTGGATCAAGTCTGTGCAACCAAGAATCACCAGGAATATATTGACCTAATGTGATGTTATTCATGTTGCACCCCCTTTAAATACGCTAAAAGAGATGCGTAATCATAATGAGGTTTGTAGACAAGTCCTACTTCTTTTTCTAATGTTTTTAAAATCTTTAACGGCGTTGGTAGATCTAAATGGAAATCATCAAACTGTGGGTGTTCAAATAACATTTCTTTGGTTCCATCAAATACAAGACGCCCATTATCTAAAACAATAACGCGTTTTGCATATTCTGCAACCAAATCCATATCATGCGTAATCATGATAATCGTTTTATCTTCGGTATCATGAATTTCTTGGAAGATCGCCATTAAATCTTTACGACCTTTAGGATCAAGACCGCGTGTAGGTTCATCTAAAACCAAAATATCAGGCTCCATCGCTAGAATTCCTGCAACTGCAACTCTTCTCATCTGACCACCAGAAATGCGAAACGGTGATTGATTAAAAAGTGATTCATCAATACCAACAATAGCGGCAGCTTTTTTTGCTTTTACTTCCGCTTCACTTTCCGTAGATTTAAAATTTTTAGGACCGAACATAATATCTTTAAGTATGGTTTCTTCAAATAACTGATATTCAGGGAACTGAAAAACAAGACCAACTTTTTGTCTTAAATAGTTAATCTTTTCATGTCTTTTAGGGGGTAAGTCTTGACCAAAGATGACAACATTTCCTTTTGTAGGTAAAAGGAGTGCATTCATATGTTGAACAAGTGTTGATTTTCCAGATCCAGTATGACCGACAACAGCAATAAACTCACCTTTGGGTTTAATATCTAGCGTGATATGACCAATGGCATCGTAATTGACTTTATAACCCCGATACGCATAGCTTACATCTTTGAATTGAATGCCCATAGTGCCTCCAAAAGCTTAGGATCCGTTTTGGGATCTTTTGCTAAATCGTTATATAAAGCCAAACCAAAGGGGAGTTCTAAGTGGGATGATTTAAGTAATTCTTCATGCTTAAATACATCTCTTGGCGTTCCCTCTAAAATCACTTCGCCATCTTTTAAAACAATTAATCGATCACTTAAGCCAGCAAAAGATAAATCATGAGTAATCGTGATGATCGTTTTATTCAACGTTTTATTTAAATACTTAATCAGTTCTACAATTTCTCTTGTTCCCTCAGGATCTAACATAGAAGTCGCTTCATCAAGAATTAAGATATCTTGTTCCATCGCAAGCGCACCTGCTATAGCAACCCTTTGTTTTTGCCCACCAGAAAGGTGATGTGGTTCTTTATTCAAAAAGTCTTCCATACCCACGAGTTTTGCGTAATGGTTAATTCTTTCCATCATTTCATCATGGGGAAGACACTGATTTTCAAGACCAAAAGCGATATCGTGTTTAACGGTCACCCCAACAAATTGATTATCGGGATTTTGAAAAACGATACCTATTTTTTTACGTATATGAGGAAGATTTTTTTCATCCAATTGCTGCCCATCGATAAAAATCTCTCCGGATGTTGGCGCTAATAAACCAACCAAACATTTAGATAATGTCGATTTACCTGACCCGTTATGCCCTAAAATAGACACCCAAGATCCTTTTTCGACAGAAAGATTAATCTTCTTTAATGCTTCATCTTCTTGATTATATGAAAAGCTTAAATCGCTCACTTTAATCATGCATGTCACCTACATTTCGTACCTTAACATTATATCATGTTAAGCAAACTTATGAAAGTAGCGAACTAAATATCACCTGTTTGTATTCTTTACTTTAAAGAATGCTTTTTATAACTTTAACAAAGAAATGTAAAAAGGTAGCCTTTTTTAACATTTTTATTTATAATGGGTATGATATCAATTTGAGGTGAAACCATGGTACATATATTTACAACAGGAAATTTCGAAAAAGAAGTATTAAAAAGTGATGTTCCCGTTTTAGTTGAGTTTTGGGCAACATGGTGCGGTCCTTGTCAACGGGTTGCTCCTATTTTAGAAGACTTAGCAAATGACGTGAAAGATTTAGCAAAAATTGGAAAACTAGATGTTGATGAAGAGTATGAAATTGCAGATGAACTTGGAATCATGAGTATTCCAACACTCATCGTTTTCAAGAATGGAAAAGTTCATCAATCTACGATTGGCGTCCAATCAAAGGAAACATTAAAGAAGCTTTTAGATTTATGAAAAACATCATTATTATTGGCTATGGACCCGCTGGTATTTCAGCGGCTATCTATTTAAAAAGACAAGGTGTACAACCCCTTGTTATTGGTAAAGATTTTGGTGCTCTTGAAGGTTATGATGATAAAGTTGAAAACTTTTATGGCCAAGCTGAACCCATTGATGGTAAAGTGCTCATTCAAAATGGCATAAACCAAGCTAAGCATTTAGGTATTGATGTCATTACAGAAAGTGTCATTTCACTCAAGAGTGTTGGTGAAACATTTGAAGTTGTGACAACCTCGCATACGTTTGAAACAAAAGCAGTCTTACTTGCTACAGGTAAAACAAGACATACCGTTAGAAGAGCGGGATTTACTCAGTTTCGGGGTAAGGGCATTAGCATGTGTGCGATTTGTGATGGTTTCTTCTACCGTCGGAAAAAAGTTGCTGTCATCGGCTACGGTCCATATATGCTCCACGAACTTGATTTCTTAAGAAAAATGACGAAAGATATTACCATTTTTACAGATGGTCACGCATTTGATGATGAGATTGATTTTCCTGTGGTCAGAGAAAAAATAACGAAGTTTATTGGTAATGAAAAATTATCACATATTGAAACAACCCAAGGCACATATGAGATTGATGGTGCATTCATTGCACTTGGAACGCCGAGTTCAGTTGAATTTGCCAGCCAACTTGGTGTCATCATCGAAAAAAACAATGTTGTCGTAAATGATAAATACATGACAAACATTCCAGGATTGTTTGCAGCTGGTGATATCATCGGTGGTAAACTTCAAATTGCGAAAGCTGTTTATGATGGCATGAATGCTGCTGACGCCATTTACAATTATCTACATCCAAAAAAATCACCTGGATTATCCAAGTGA

Protein sequences of DBSCAN-SWA_1

>MIDB01000020|45949:52218|45949_46894_-|OHE42674.1|DBSCAN-SWA
MKRAYYFFKQTIQKNRLAHLYLIVGPKGSGKSQLVDDVAYLILNQGKAESPHLKLQIKERKVQNMSVIEPDGLSIKKEQILALQNEFSKTALVSGPRIYVIKGIEKISIAAANSLLKFMEEPQSQQVFGFLLAEDKEDVLRTIQSRSQILTLKSIDELDLEEELIKLGVDEKVATLAPYVTKNIEEATLLAENPNFLDLIALIEEIARLWDKKDVSYPIHFAQKSGFLMQDRDFFMDFLELLLLYFLDFVHYRTHQPLVYKFLKDVIQIQSDRMQVLEVNDLIEQIQTVLQQQSYNINLDLALDHLFYILEKKR
>MIDB01000020|45949:52218|50035_50839_-|OHE42679.1|DBSCAN-SWA
MIKVSDLSFSYNQEDEALKKINLSVEKGSWVSILGHNGSGKSTLSKCLVGLLAPTSGEIFIDGQQLDEKNLPHIRKKIGIVFQNPDNQFVGVTVKHDIAFGLENQCLPHDEMMERINHYAKLVGMEDFLNKEPHHLSGGQKQRVAIAGALAMEQDILILDEATSMLDPEGTREIVELIKYLNKTLNKTIITITHDLSFAGLSDRLIVLKDGEVILEGTPRDVFKHEELLKSSHLELPFGLALYNDLAKDPKTDPKLLEALWAFNSKM
>MIDB01000020|45949:52218|47507_48242_-|OHE42676.1|tRNA|DBSCAN-SWA
MRYKAVVSYDGSNYIGFQSQHNGLGIQEVIEKALRLMTQTEIKIHSAGRTDKGVHALGQVFHFDSKIDLPSDIWVRGVNDRLPLDIRLKSVKKVASDFHARHSATSKVYRYVIAKNPETPFTKNYEVYIRNLDINPIKEALPLFVGTHDFRGFCQLVPGKPTVKTIHEVTLKETSKHYVFTFHGNSFLKYMVRSMMGTLIQIGLHRKEPGIISTILETKDRHLAGKTAESRGLFLVKINYKKRT
>MIDB01000020|45949:52218|48238_49219_-|OHE42677.1|DBSCAN-SWA
MNNITLGQYIPGDSWLHRLDPRIKLFSLVILLVGTFIIPISADLIPIITMVAIFLGMMILTASAGIPIKKVINGLRPIVFLLTFTFFIQLFFITEGELLVSFDFYLSVASIGAILILFVFYNWSKKYIKFRILYFLLIVGLIFFVQAVLPYISLYTYKLDVYDQGLLRAGFIFIRITNVIIMTSLLTFTTMTTDLNYAIESLLKPLKWIKVPVDVIAMMLSLTLRYIPTLLGETEKIMKAQASRGVDFKESKFKDKVVQIISLLIPVFVISFKRAEDLGNAMEVRGYVIGAKRTKIDQYKIGFKDIMAVFVVTLFLAIIIMMRIIG
>MIDB01000020|45949:52218|51342_52218_+|OHE42681.1|DBSCAN-SWA
MKNIIIIGYGPAGISAAIYLKRQGVQPLVIGKDFGALEGYDDKVENFYGQAEPIDGKVLIQNGINQAKHLGIDVITESVISLKSVGETFEVVTTSHTFETKAVLLATGKTRHTVRRAGFTQFRGKGISMCAICDGFFYRRKKVAVIGYGPYMLHELDFLRKMTKDITIFTDGHAFDDEIDFPVVREKITKFIGNEKLSHIETTQGTYEIDGAFIALGTPSSVEFASQLGVIIEKNNVVVNDKYMTNIPGLFAAGDIIGGKLQIAKAVYDGMNAADAIYNYLHPKKSPGLSK
>MIDB01000020|45949:52218|49211_50060_-|OHE42678.1|DBSCAN-SWA
MGIQFKDVSYAYRGYKVNYDAIGHITLDIKPKGEFIAVVGHTGSGKSTLVQHMNALLLPTKGNVVIFGQDLPPKRHEKINYLRQKVGLVFQFPEYQLFEETILKDIMFGPKNFKSTESEAEVKAKKAAAIVGIDESLFNQSPFRISGGQMRRVAVAGILAMEPDILVLDEPTRGLDPKGRKDLMAIFQEIHDTEDKTIIMITHDMDLVAEYAKRVIVLDNGRLVFDGTKEMLFEHPQFDDFHLDLPTPLKILKTLEKEVGLVYKPHYDYASLLAYLKGVQHE
>MIDB01000020|45949:52218|46890_47493_-|OHE42675.1|DBSCAN-SWA
MFITFEGGEGTGKTTLIQGIAAVLRNQYNVVTTREPGGSNIAEAIRDIILNPKYQGVTPYTEALLLAASRAQHLDEVILPALRAQKIVLCDRYIDSSLAYQAYARNLGFDFVLSINRYAVENLPNLTFYIDLDPKIGLSRIAHRDKYDRLDQEAFDFHTKVREGYLEVAKRYQERIIVIDGSQTIEKIQEQILEEIEKHL
>MIDB01000020|45949:52218|51034_51346_+|OHE42680.1|DBSCAN-SWA
MVHIFTTGNFEKEVLKSDVPVLVEFWATWCGPCQRVAPILEDLANDVKDLAKIGKLDVDEEYEIADELGIMSIPTLIVFKNGKVHQSTIGVQSKETLKKLLDL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
OHE42674.1|45949_46894_-	hypothetical protein	M1NSC1	Streptococcus_phage	4.4e-16	34.9
OHE42675.1|46890_47493_-	dTMP kinase	M1PSC7	Streptococcus_phage	3.7e-40	48.5
OHE42676.1|47507_48242_-|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
OHE42677.1|48238_49219_-	hypothetical protein	NA	NA	NA	NA
OHE42678.1|49211_50060_-	energy-coupling factor transporter ATPase	W6JKT0	Anomala_cuprea_entomopoxvirus	1.4e-13	27.6
OHE42679.1|50035_50839_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	3.2e-23	34.6
OHE42680.1|51034_51346_+	thioredoxin	A0A1J0GW78	Streptomyces_phage	1.2e-18	47.9
OHE42681.1|51342_52218_+	hypothetical protein	A0A1V0SIN1	Klosneuvirus	2.0e-26	32.4

2. MIDB01000013

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	76892 : 89889	15	Caldibacillus_phage(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>MIDB01000013|76892:89889|DBSCAN-SWA
AATGAAAGGGAAAATGCTAGATCTGTATGAGCGTTGGGAAGAATCTGGGCATCTAAATAGTAGATTAAAAGCCATATCTGAAATGATATCTAAAAGAGCGACTCAAAGACAGGTTGCTGAATACTTAGGTATTACAGAAAAGACACTCATTAAGTTAAGAAAAGCCCATCCTAAATTGAACAAAGCATTTCAATATGGGGATGAGGAGTTAAAAGAGAAGCTTGTCGATGCAATGTATCAACGGGCTGTTGGATTTGAATATGAAGAAACACAAACTGTGATTGAAGAGACTAAATCGGGTACTAAAAAACGTATCACAAAGTATAAGAAGCAGTCGCTTCCTGAAATCACAGCGATTAAATATTTACTCATTACAAAGTTCGGTATTGAGTATAACGAGAAAAAAGCAGAAATAGAACTGATGACCAAACGATTAGAAAAAGGTGAAGAGGTATGGATCAATGAATATCGTGATGAAGAAAGTATCAGTACTCCAAGAGTACGAAAACAATCCAAGAAACAATGATGCTGCAATTGATGCGGTCGCTAAGAGTATTGAGGAGTTTGGATTTAAAGTTCCAATTGTGATCACAAAAGATCATGTCATTATTGCAGGACATACAAGACTAAAGGCAAGTCTTAAGCTTGGACTAGATGAAGTGCCTTGTATTATTGCTGATGATTTAACAGAAGAACAAATCAAAGCATTCAGACTTGCAGATAACAAAACTGCTGAGCTTGCGACTTGGGACTTTGCTAAACTTGAAGAAGAACTAGCAAACATTGAAATGGATATGTCACTCTTTGGATTTGAGGAACTAGAAGCTAATGTACCAGATAATGCAACCGATGATGACTTTGATCCAACAGATGATCTATCAGATGCGCCTTATTCACAAAAAGGTGATGTTTATATCTTAGGTAATCACCGAGTGATGTGTGGCGACTCAACAGAAAAAACTGATGTTAAGAAACTGATCCAAGATGATCGGATAGATTTAGTTTTTACAGATCCACCATACAATGTCGATTATGAAGGTACAGCTGGAAAAATAATGAACGATAAGATGGAAGATAATACCTTCTATCTTTTTCTTTATAAAGCCTTTGAGAATATGTTTGAGCATACGAAACCAGGTGGTGCTATTTATGTATGTCATGCAGACACAGAAGGCATCAACTTTAGAAATGCTTTCAAGAATGCTGGGTATAAACTTGCAGAGTGTCTTATCTGGGTAAAGAATGCACTTGTTTTAGGTAGACAAGATTATCACTGGCGACATGAACCTATTCTTTATGGTTGGAGAGAAGGTGCTGCTCATTACTTTGTGGATGACCGTACTCAAGATACCATCTGGGAATATAACAAACCAAAACGAAATGAAGAACATCCTACAATGAAACCGTTAGAACTCGTCGGTAAAGCTATCGCAAACTCATCTAGAGTGAATGAGATAGTCTTAGATTTATTTGGTGGTTCTGGATCAACCATGATCGCATCTGATCAGCTTCAAAGAAGAGCAAGAATCATGGAACTGGATGAACGATTTGTGGACGTGATTGTAAAACGCTATTTAAAGTACAAAGTATCGCTTGATGATTGTTATCTCATTCGTAATGGAAAAGAGATACTACTTAGCCAAATCAACGACTTTCAGATATTGTCACTATAGTGAGCAAATCATGTCGAATTGACTTGCTATTTGATGCCTTTAGAGTGATATATAGTAGTAACCAAAAAAGGTTAGGAAAGAGGCAATAGCGATGAAAGTCAAATTTGAAACGAGAGCATTCAAAGAACAGATTATTCCACAGGATGATTTTGTAGTTGAGAAAGTTGTCGAGATATCACAAAGACAGTTTAATAAGTTCTTAGATGATATGCTTGGCGATTATGATTTCATAAAAGCTCACAAGGATTTAATGTACACAGACAGCAAAAACGTGTGGCACGCAATTTTAGTAACAACTAAAGCATTAGATTATGGAATCCTAGTACAGGCAGATGGTTCGAATTATGCTAGATACTCCGCATTTATTAGAAAAAGTGAGATAGGAGGATTTGATGATGGAAAAACAACAACCGCTTAAAGATTGGATTCAAGCGTTCAATAGTGGAAGCTTTGAATCAAGTGATGTAAAAGTTCAAATCAAAGCTGGCTGGTACGATTGGTTTTGTAAAGACTCAAGTTTAAAGAATAAAACCAAACGCATGGGCAATATCATCAAGCAAATTAAACCAGGCGGCAAGGTTGATCTAGATAACAGTTATGTCTGGTTCAAGAACAATTGTCCACTTCAAGGTAGTCTTTATGATGATTTTAGAATTGCAGATTTAGAATCCGATGTTACATTGATTGTCGTTCAACTTAACTCGCCATGGCATGATAAGACGTACACAGTCTATGAACGATTAACACACTATGAAAAAGTTGTATTCTCAACGGACTCAGTTAAAGAACTTGTTAAGTGGTTAAACGAAGGGTGGGATACGCATGTATAACTATTACAACAGACATCCCAAAGGCATCAAAACTGGTGACTGTGTGGTCAGAGCAATTTCAACAGCATTTGATAAAGACTACATGGAAACAAGAAGAGAACTCAATCAGAAAAAACGTGAATGGAGTTTCACCAGTTACAAGGATACAGAGTTTATCTATAAGTATTTAGAGAATCGACCAAGATACATTTTTAAAGCGGTTAAGGGTGAACCCAGGATTAAAGGTACAGGCTTTGCACAACTACATCCAAAAGGAACGTTTATATTAAAGATGGCAGGACATATTAGTGTTTGTAAAGATGGTGTCATACTAGACATTTGGGATTGCACCTATAGAAGTGTTTATACAGCATGGAGAATTGACGAGGAAACAACATGAAAGTAAATTTTATAAGAAAACCAACACCAGAGGAACTTATCCCTCAAGACGAATTTATAGTCGAAAAAACAATAATCCTAGAAAGTGAAGTATTTGAAGGATTCATCAGAGACCCATTAAACGACTATGATTTCATCAAAGAACATCTAGAACTGATGTATTGCGATAAGGAAGGTATATTTCACTGCTTGTTAGTCACATCGGATAAACATGACTTTGGTATCCTGGTTGAAAGTGAAGGATATCATTACGCAAGGTATGCAGCATTCATACCACTCATCAAAAACAAAACAGAAAACTAAGGAAGCGAGCAAGCTTCCTTTTTAACTATTTAAAGCGAGGATAACAAATGAAAATTATAACAAGTGAATCTGTCTTTAAAGGACACCCAGATAAAATATGTGACCAAATTAGTGATGCAATCTTAGATGCACATTTAGAACAAGACAGAAATGCAAGAGTAGCAGTAGAAACAGCCATCAAAGATGATGTTGTTTTTATCTTTGGTGAGGTCACATCTAAAGCTTCAGTGAATTATAAAGAAGTGGTACTAGACACATTAAAAGAAATCGGATATGATGATCCATTCGATGTGATTGAAAAGATATCCAAACAATCAGATGATATTGCACTTGGTGTGAATCATACGAATGATCATGAACAAGGTGCAGGTGATCAGGGCTTAATGTTTGGCTACGCTTGCAAAGAAACGCCTGAATTAATGCCTTTACCAATCGTAGTGGCACATGACATCGCAAGAAGCATTGACGAGCTTAGAAAGGCAAAGTATGGCCACGTGTTTGGACCAGATGGTAAGTGTCAAGTTTCTGTTGTTTATGAGAACGATGAACCGATTGCATATGAAACAATCGTAGTGTCTGCTCAAACAAAACATGGCATTCAATTAGATTATGCTAAAGAGATAATCTTAGATGAAGTATTGAAACCACTCATCGGTGAAGATCTTTCTCACATTCAAGTCTTAATCAATCCAACAGGTGCTTTTGTCGTTGGTGGACCATATGGAGATTCTGGATTAACAGGTAGAAAGATTATTGTTGATACCTATGGTGGTTATGCTAAACATGGCGGTGGTGCATTTTCTGGCAAAGATGTGAGCAAGGTAGACCGCAGTGCGGCTTACTATGCTAGATTTGTAGCAAAAGCCCTTGTAGCGGCTAATTTGGCAGACAGGTGCGAAGTTAGTGTGTCCTATTCCATCGGAGTAGCAAACCCAGTAAGTGTATCGGTTGATACCTTTGGAACAGGGGTTACTTCGGATGAGGTTCTATTGAAGTTGATTAAAGAGAACTTCAACTTTACACCATCAAGTATTATCAAAGAATTAAACCTGGACAAGGTGAAGTTTAAACCCTTAGCAGCTTATGGACATATTGGACGTGTGGATCTTGATGTTGCTTGGGAACAAGTAGACGCTAAAGCAAAACAACTAAGTGAATCTTATGAGAAAACCAAAAGAGCTACACAGGTTCTATAAATCGAAGGCTTGGCTTGTTGCTCGCAATATCAAAACAAACGCCACACAGGGCAAGTGTGAGCGGTGTGGTGCAATTGGTGAAGAGGTACACCATAAGATTAGGTTAACAGTTGATAATGTCAATGACACCAACATAAGTCTGAATCAAGATAATCTGGAGTTGTTATGTAGGGATTGTCATAATGAAGAACATGAAAGATTTAAAAAGAAAGAAGTATTATTTGATTCCGATGGGAATTTCATAGTATAACTGGTATAATAAAACAAAGTAAAAAGGAGACCCAATCTTGTGAAAACACTGAATGTTAAGGACTTTAATATAGGAAATCTCAAAGCAGAATTTTATTCAAGTTTTGAAAGAACAATAGAGATAAGAGTTTCAAAAGATGAAAAATACGACGTATTTGAGATTGGTTATATTAAATACAATGATAAAAATATTGTACTTGCTGTTATAGAAGGCACCGATGAAAATATGAATGAAACAAAGATACCTTTAATTGCACAAACTGAATCAAAGGATAAGAAAGAATATATAATAATATTTGATTATGAGACCTATAAAAGGATGGATGAGCAAGCATTCAGATGGTACATTGCCCATGAAGTTGGTCATGTTATTTGCATAGAGAATGGAAAAGGATATTCGAATCTATCCTATGAAGAAATAGTAAAAGAGGTTAACGAGGGTAAGGTTAATCAACATGAACATGAAGCTGATTTAGAGGCAGTAAAACTTATGAAAAATAAAAATACATTCATAAAATCGTTAGAGTATTTAATTACACGTTCTAACATGCAAGCAGATGCACATTCAGAATTTGAAATAGTTCGAAGAAAGTCATTAGAATTAAGAATTAATGCTATAAAAAACTATAACCCCCCCTCTTAATATTGAAATAATTACCCAGGGTACCGCATGGGTGGGCTTTTAAAAAATGGATGGCAATTTTTTTGAAAATTTGGAATTTAGGTGCAGAATATGAAACCCTTTTTAGATGAAAGCAAAATAAATAGGTTTAGAGAACTCATTAATTCATCACCCATTTTTTATAGAGATGAAAAGCACGCCAATAATTGGAACTTAATCTGTGCATTTATGGATAGGATAGACGACTCAATAAAATCTCTAACTGCTCATGATTTTCTTGCTGAAGATACCCGCTCAACTGATAATTTAATTTTATTTATAGTTCATACTGATATTATTGTTGAATCAATTAATAAGCTCTTTGATAAGCTAGGAATTGATAATCCACTAAAAGATAAAATTGATATATTTAATCAACTAGGCGATGGACGAGGAACAGATAATAAGTTCTTTAAACACCTAAGAGCTTTATCATTTGCCCATTCAATTGAAACTGCGCATGCAAGTCCATATGTGAAAAAGGGTGAAACCCAATACTCACCGTACATAATGAACCATTCATTATTTCAGGAAAACTATATCACCATTAGTGTTTATTCCTCGATAGAAGAGAATGATATGAATACTATTAGAATTCCTAAGTTGCAGCTCATTAGGTTTGTTGAGAGCAGATACGATTTAGTTGATTACTTAAATGATTATCTACAAGAAGAGGTTACAAATCATAATGATCAACAAATTAGTGATGTTATAGAAATTTTAGAAGATCCAATTCAAACGTTGTCAAATTTAAAACAAGCAGCGGTTAGAAGATATGATGACTCACTTATTAACTACATTGATGAGATCATCTATACTTTAAAATATCAAACATCAAATGAGAAAAATCAGAATGCTGTTGATAAGCTGAAAGACTTTATTATAACTGCGATTAGTGAGTTTATAGCCTTGTACCAGATAATGGATGACTCACATTACAATCATGTATTTATGTCTGCTTTGAGTTTTCAATGGAAGACTGATATTCCAATGGCCCATTATATGTTAGAAAAAATCAGATTGTATTTGATTGAAGAGTATGGTCCTAATGTGTATAATTTCGATCAATCAAGTCCATATGATCCAAATACTGAGTCTAATGTTGAATGGGGATTTCAACAATTGAAGATATTCAAATCAGTATTGGCTGATGATTATGTAGAAATAGATTATCATATGCCATTCAAGGAGATACAACTTTTAGTATCAGCAGCACTATATTTGAATCATGTTGCCAAAAAAGGATAAAGTCACTATAGTGGCTTTTTTCAATAAAAAAACAATGTTTGAATTGAATTATTCATTTCAACTAAACATTGTTAATTTACAGTTACTTTTTCTTCTTGCAATTAAGTAATAGATTGAGAATTGAGACCAATAAACCTATTAAAGAAATCACTACTCTTAAAGAATCTAGACTCACAGCATTTCACCTTTTTCTAGAGGTTATGCATTGATAAAACAAAAAGCAATGCAAAAATTTAACTTTGCATTACCCGACATACCTTTTTTTACCTAGTCAGTTTCTAGTTCTATGTCCGACGTTTTTACCTCTGTCGATGAGTAGTGATTTCTTTCGAGTTTGACCTGTTCTCTCAGTTTAAAAGCCTTTTACCTGTATGGTCAGTTTCTTGGTAATATTTAGAGTTATCCTCTAACTATATTATACTAAAAATACTACACAAAATCAAATATCACTATACTGAATGAGCGAGGTAATGAGCTATATGAATAAAGTGAAAGTTGAATATGAGCGACTTCGGTCGCTTTTTTCATCGGTTGATGAAACAAAAACAAAACTGGTTGACAATCTTATTGAACAAGCAGCATTTATGAAGATTGAACTTGGAATCCTTCAGGACCAAATAAGAAAACATGGAGCTATTCAGATATCAAATAAAGGTGCTCAAAGACAAACTGAAGCAGCGAAGTATTATACAAAACTAGTGAATTCATATGGAACAGTCATCAAAACACTTAATTCAATAATGGGTAAAAACATTATTGAAGAAGATGATGATTTTGACAAGTTCATTGGTAGAATGTCATAATGAATTATTTAATTAAATATTATGATGAGATTCAAAAGGGAAATATCATAGTTGGAAAAGAACTATTGACAGTCTTAGAATCACTCATTAAAGATATTGATAACCCAAGATACATTTTTGATGAACGTCCTGGGAATATTCGAATCGAGTTTATTGAAACTTTTTGTAAACATACCAAGAGTCCATTTAATGGTGAACCATTTATTTTAGAACTATGGGAGAAAGCAATCCTTCAAGCAGCCTATGGATTTAAGATGGCGGAAACAAATCTAAGAAGATTCAATGAAGTAATACTACTCATAGCTAGAAAGAATGGTAAGACAACATTTATTGCAGGCATAGATCTGGCAGAATTCTTTCTATCAAAAGGTGGTGTCGATATTGTATGTGCATCTAATACCTCAGAACAAGCTAACATCTTATTTGATGAAATCAATAATATGCGAGAAGGCTCAAAAGCTCTATCCAATGAAAAAAGAAGTAAAAAAAATATCTTCCACATATACTCGCCAAAAACCAAAAACAAAATAAAGAAACTATCTGCTCAATCAAGAAATAAGGATGGCTACAATATTGAGGTTGGTTGTATTGATGAAGTTCATGAAATGACTGATTCAAAAGTCTATGATGCCATAAAACAAAGTCAATCAACCAAAGAAGAACCACTAATTTTTATTATTACAACAGAAGGTAATACAGTAGGTGGATTCTTAGATAGTAAACTTGATTATGTTAGAAAGATGATCAAAGGGGAGATTGACGATGAACGAGTACTTCCTTGGTTATATACTCAAGACTCAATTAATGAAATCTATGAAGATAAGAATACATGGCAAAAAAGTAACCCAAGCTTAGGCACTGTAAAGACTTACTCCTACCTTGAGGATTTAATGAATAAATCCAGACACGACCTAGCTACACGAGTTACGATGCTTTGTAAAGATTTCAACGTAAAACAATTAGAACAAGGATCATGGTTAACATATAATGATCTAAATAATGAAGCAACCTATGATATCAATGAGCTAAGAAACAGTTACGCCATTGGAGGTGTTGACTTATCATCGACAACTGACCTTACAGTTGCTCTATTATTATTGATAAAAGATGGTAAGAAGTATGTTATTCCACAATTCTTTATGCCGAGTGAAGTTATTAAGCGCAGAAAAGAAGAGGATAACGTACCATATGATATTTGGGTTCAAAGGGGATTGATTACAGTAACTGAAGGTAATCAAAATGACTTCACACTAGTTACACAGTGGTTTTTAATGATGATTAGAACATATGAGATTAGACCTTTATGGGTTGGGTATGATCCCTGGAATAGTCAGTACTGGACTAAAGAAATGGAAGATTTAGGTTTTGAAATGGAAAAGGTCAGACAAGGGATATATTCCTTATCAGAACCGATGAAACAATTAGAAGCAGATCTAAAAAACGGTAATGTGATATACAACAATAATCCAATAATGAAATGGAATTTATCGAATACCCAAGCTAAGATAGATATTAATGGAAACATTCAACCATCAAAACTTGGTAGTAAATATAAAAGAATTGATGGAGCTGTAGCACTTATCATTGCATATTCGGTTCTTAATAGATACAAGATTGAATATGAGAATATGTTATAATTTATGTGGGTGATTCAAATGGATATTAACGATATTGAGAGCAAAGTCAAGATGATTTCTAAGTTTTTAAGTAAAGAAAGTATAGATGACAATTATGAAGATATAAAACAAACGGTTAGCGAGATAATTACACCTACTATAATTTCTTATGTCGAAATTGATAGATTGTTTCTTTTTAGGGCAAGAAAACTTAATGCTTTAATTAATTTCGATAATTTATCAGCTCAGGATATTTTTATGCCACCAGCTGAGTTAACTGAAATGGGAAGGGGAAATATGAAAAGAAAGCCAGTGCTTTATGCGGCATTGGATCCTGTAACAGCTATAAATGAGACAGGAATAAAAGAGAATGATTATTTCTTGCTTGGATGTTTTGAATTGCTAGAAAATGGTGGCTCTCACTCAAAAGAGAGAACATGTGTAATAGGAATTACTAAAAACGATAAAAAAGAAGATCCTATTATGAGAATTGCACAGGGGATCTCATCGAATTTCTTATATACTGAGTTCACCAGAGAAATTACAAAATGGAATAAAAATAGATACTATATATCTAATGCTATTGTCGATCATCTTTTTAATAAGATGAATTTTAGAAGTGTCATATATCCATCGGTTATCAATAATAAACGACTCAATATATTGCTTAACGAACAAGCAGCTAGTGATAGATTAGCATTTGGCTATATGTATGTTTGTAAAATGCTTGAAGTAAATGGAACTCAGTTTAAAGCCCACATTTATAAAAGCCTAGATGATACAACAACCAAAAATGAACTTAAATGGAGAAAGCTTGATAATCAAAGGTTATTCACATATAAAAGTGAAGGACCTAAGGATCAAGTAGAAGTTATTAAAAAACGAATGTGTAAGCATTTTGAATAGTTTTTAAGGAGGTCTATATGGCCATATTCAAACGAAAGAAAAAACAGGGCTCAGTTGAGACCTTTAAATTTGTAAATGAAATAAATCTACCACTTACAAGCTTTGGAAATAACATCTCAAAATCAGATGTCGTAAAGATTGCGATTGATAGGATAGCAAGTCAGTGTGCAAAACTAAAACCAAGATATATAAAGAAAGCGAATGATAAGACAGTTACAGAGAAATCTGGCAAACTGTCTTTTATTTTAAAGCATCAACCGAATGAGGTCATGACCCCTTATCAATTTATCTATATGGTGATTACGACGTTGTTGATGAACGACAATGCATTTATCTATCCTATGTTTGATGGTTCAACCGGTGAAATCAAAGCTCTTTATCCACTTAAACCGTCCATCGTTGAGCCAATCATAGATTCAGGTGGTAGTTACTATTTAAAGTTTAGCTTTGACAGTACGGATTCCTTCACGATTCCATATGAGAACATTATTCATATTAAAAGGTTTTACCATACGAATCAGATCTTTGGAGGATCAAGTTCAAAAGGTGACCAAGAAGCACTCTTAAAGACTATACAAATCAATGAGAATGTACTTCAAGGCATTGATAATGCTCTTAAAAGTTCCATGCAAATTAAGGGACTTCTTAAAATGAGTGCCATGCTAAGTGAGACAGATAAAAAGAAACAACTGGATTCATTTAACGAGATACTCAAAGAGTCCATTAGAAATAAGGGCAGTTCAATTATTCCTGTGGATTTAAAAGGTGATTATGTTCCTTTAACAACAGACCCAAAACTAATAGATAAGGACACCTTAGAGTTTTTACAATCAAAAATCCTAGATTACTTTGGTGTATCAGTTCCAATCTTTCATTCCAAATATACAGAAGATGAGTTCAACTCATTTTATGAACAAACCATCGAGCCTTTAGCCATTCAAATGTCTGAGGCTTTTTCTTTAGGCTTGCTTACTCAAAATGAAATCATGCGTGGTGAAGAGATTATCTTTTACAGTGAAAGACTTCAATACGCATCCTGGAACACAAAGGTTACAGCTATTGAAAAACTCATGGGGTTAGGCATTATGTCACTGAATGAATCAAGAGGGTTGTTAGGACTTGAACCTGTTGAAAACGGTGATAGAAGATTACAATCACTCAATTACGTCGATGCTACAAAAGCAAACGAATATCAAGTAGGGAAGGATGATTTAAATGAAAGTAACAATTAATGGTAAGGTTTCAAAAGATGTATTAAATACTGTTTTAGAAGAACAAAAAGAAAAAATTAATACAATCGAAACCTTTTGTAAGACACACAAAATTAATGAGTTTTCATACAAGGACAATGAGCTTGAATACGTGTATGAAAAGCAAGCAACAAAACCTAAGGAGGTTGAGAAACGATGAAGAAAGAAACCAGAATAGCAGAAGTTAGGCTAGAAGAAACCGATGACAAGATGGTCTTAGAAGGTTATGCGATCGTTTATGATGAACCCACTTTAATAGGTGATGAATCCTATGGGTTTATCGAAAGTATTAGTAGAAGTGCAATCACGGATGCAGCAATCAAAGATGTACCAATGAAGTATAACCACATGGACTCATTTTTAATCATTGCTCGAACTAAAAACGGCTCACTTACTCTAACAAGTGATGATGTCGGATTAAAGGTTAGAGCTGAGTTACTAGATACACAAAGCAATCAAGATATCTTTAAGATGGTCAAATCAGGCTTGTTGGATAAGATGAGCTTTGCATTTGTTGTAAGTGAGCAGGAATGGAATCGTGATGGTGATATTCCAAAAAGAACTATCAGAAAGATTGAACGTTTATATGATGTTTCAATCGTTGACACACCCGCTTATGATAAGACTTCGATTTATGCTCGTTCTTTAGAGGCTATGGACTTAGAACTAAAGACTATGGATTTAGCAGAGAAAAATATGAAGGCTGAACTTATAAGAAAAAAACTAAATTTGAAAATAAAAATAGGAGAATAAGAAGATGAATTTAGAAAAAAGAAGTAATGAAATTAAAGCACGCATCACTGAAATCAAAGGTTTGATTGGTGCGGAAGTAACACTTGAAGTGTTAGAACAATTAGAAGCTGAAGTTGATGAATTGAATAAAGAGAAAGATACAATCGAAAGAAAGCTCGCTATTCAAAATAAAACGAAAATCAACCCTGTTGTTATTGAAAGATCTAATCATGTGGACAAAGATCAATTAGAAACACGTGGTAAAAATTTAAGAGAAAGTAGAGTCATTCAAGTTTCAAGTGAAGAGATTCTATTACCTGAACACGTTGCCGATGGCATCGCACCGCATCCATTTGCACAAGTATCTGCATTAGTGGATAAGGTAAAAGTTGTGAACTTAAATGGTGGGGAAACCTATAAGAAATCTTTTGTTAAAGGTAGCGGTATTGCTGGTTTAACTGGAGAGGGTGAGCCTTATTCAGAAACAGAACCAGAGTATGGTTATTTAACAATCACTAAGGTGAAAGTTACTGCTTATACAGAAATCACTGAAGAGTTAGAAAAACTACCTAACTTACCATATCAAGCTGAAGTCTTAAAGAACATTAATCTATCACTCAAAAAGAAGATTAGTGAACAAATCCTAAGAGGTCCAGGTACATCCAATACATTCACAGGAATCTTTAGTGATAAGGCAATCGCTTTATCGGATACTGCTGATTTAGAAATCACATCGATTACTGACTCAACATTAGATGATATCATCTTTGCTTATGGTGGTGATGAAGAAGTCGAAGGTGGAGCATACTTAATCCTTAACAAGAATGATTTAAGAGCATTTGCTGGCTTACGTACTGCAGAAGGTAGAAAAGTCCACACGATTGACTACATCAACAACACGATTGATGGTATTCCATACATCATTAATTCTCATTGTAAGGCTATATCAGATACAAACACTGCAGCTGGAGAATATGGTCTTGCATATGGATCCTTACTCAATTATGAAGTGCCTGTTTTCTCACCTGTTGAGATTAGCAAGTCTAATGATTACAAGTTTAAAGATGGCATCATTTGCTACAAGGCGTCCGTATTTACAGGCGGTAACGTTGTAGGATATAAAGGCTTCTTAAGAGTTAAAAAGAAAGCCTAA

Protein sequences of DBSCAN-SWA_1

>MIDB01000013|76892:89889|81560_82163_+|OHE43770.1|DBSCAN-SWA
MKTLNVKDFNIGNLKAEFYSSFERTIEIRVSKDEKYDVFEIGYIKYNDKNIVLAVIEGTDENMNETKIPLIAQTESKDKKEYIIIFDYETYKRMDEQAFRWYIAHEVGHVICIENGKGYSNLSYEEIVKEVNEGKVNQHEHEADLEAVKLMKNKNTFIKSLEYLITRSNMQADAHSEFEIVRRKSLELRINAIKNYNPPS
>MIDB01000013|76892:89889|79386_79773_+|OHE43766.1|DBSCAN-SWA
MYNYYNRHPKGIKTGDCVVRAISTAFDKDYMETRRELNQKKREWSFTSYKDTEFIYKYLENRPRYIFKAVKGEPRIKGTGFAQLHPKGTFILKMAGHISVCKDGVILDIWDCTYRSVYTAWRIDEETT
>MIDB01000013|76892:89889|77352_78564_+|OHE43763.1|DBSCAN-SWA
MNIVMKKVSVLQEYENNPRNNDAAIDAVAKSIEEFGFKVPIVITKDHVIIAGHTRLKASLKLGLDEVPCIIADDLTEEQIKAFRLADNKTAELATWDFAKLEEELANIEMDMSLFGFEELEANVPDNATDDDFDPTDDLSDAPYSQKGDVYILGNHRVMCGDSTEKTDVKKLIQDDRIDLVFTDPPYNVDYEGTAGKIMNDKMEDNTFYLFLYKAFENMFEHTKPGGAIYVCHADTEGINFRNAFKNAGYKLAECLIWVKNALVLGRQDYHWRHEPILYGWREGAAHYFVDDRTQDTIWEYNKPKRNEEHPTMKPLELVGKAIANSSRVNEIVLDLFGGSGSTMIASDQLQRRARIMELDERFVDVIVKRYLKYKVSLDDCYLIRNGKEILLSQINDFQILSL
>MIDB01000013|76892:89889|83908_84232_+|OHE43772.1|DBSCAN-SWA
MNKVKVEYERLRSLFSSVDETKTKLVDNLIEQAAFMKIELGILQDQIRKHGAIQISNKGAQRQTEAAKYYTKLVNSYGTVIKTLNSIMGKNIIEEDDDFDKFIGRMS
>MIDB01000013|76892:89889|82253_83429_+|OHE43771.1|DBSCAN-SWA
MKPFLDESKINRFRELINSSPIFYRDEKHANNWNLICAFMDRIDDSIKSLTAHDFLAEDTRSTDNLILFIVHTDIIVESINKLFDKLGIDNPLKDKIDIFNQLGDGRGTDNKFFKHLRALSFAHSIETAHASPYVKKGETQYSPYIMNHSLFQENYITISVYSSIEENDMNTIRIPKLQLIRFVESRYDLVDYLNDYLQEEVTNHNDQQISDVIEILEDPIQTLSNLKQAAVRRYDDSLINYIDEIIYTLKYQTSNEKNQNAVDKLKDFIITAISEFIALYQIMDDSHYNHVFMSALSFQWKTDIPMAHYMLEKIRLYLIEEYGPNVYNFDQSSPYDPNTESNVEWGFQQLKIFKSVLADDYVEIDYHMPFKEIQLLVSAALYLNHVAKKG
>MIDB01000013|76892:89889|88761_89889_+|OHE43776.1|DBSCAN-SWA
MNLEKRSNEIKARITEIKGLIGAEVTLEVLEQLEAEVDELNKEKDTIERKLAIQNKTKINPVVIERSNHVDKDQLETRGKNLRESRVIQVSSEEILLPEHVADGIAPHPFAQVSALVDKVKVVNLNGGETYKKSFVKGSGIAGLTGEGEPYSETEPEYGYLTITKVKVTAYTEITEELEKLPNLPYQAEVLKNINLSLKKKISEQILRGPGTSNTFTGIFSDKAIALSDTADLEITSITDSTLDDIIFAYGGDEEVEGGAYLILNKNDLRAFAGLRTAEGRKVHTIDYINNTIDGIPYIINSHCKAISDTNTAAGEYGLAYGSLLNYEVPVFSPVEISKSNDYKFKDGIICYKASVFTGGNVVGYKGFLRVKKKA
>MIDB01000013|76892:89889|78956_79394_+|OHE43765.1|DBSCAN-SWA
MMEKQQPLKDWIQAFNSGSFESSDVKVQIKAGWYDWFCKDSSLKNKTKRMGNIIKQIKPGGKVDLDNSYVWFKNNCPLQGSLYDDFRIADLESDVTLIVVQLNSPWHDKTYTVYERLTHYEKVVFSTDSVKELVKWLNEGWDTHV
>MIDB01000013|76892:89889|76892_77417_+|OHE43762.1|DBSCAN-SWA
MKGKMLDLYERWEESGHLNSRLKAISEMISKRATQRQVAEYLGITEKTLIKLRKAHPKLNKAFQYGDEELKEKLVDAMYQRAVGFEYEETQTVIEETKSGTKKRITKYKKQSLPEITAIKYLLITKFGIEYNEKKAEIELMTKRLEKGEEVWINEYRDEESISTPRVRKQSKKQ
>MIDB01000013|76892:89889|78655_78982_+|OHE43764.1|DBSCAN-SWA
MKVKFETRAFKEQIIPQDDFVVEKVVEISQRQFNKFLDDMLGDYDFIKAHKDLMYTDSKNVWHAILVTTKALDYGILVQADGSNYARYSAFIRKSEIGGFDDGKTTTA
>MIDB01000013|76892:89889|85887_86754_+|OHE43774.1|DBSCAN-SWA
MDINDIESKVKMISKFLSKESIDDNYEDIKQTVSEIITPTIISYVEIDRLFLFRARKLNALINFDNLSAQDIFMPPAELTEMGRGNMKRKPVLYAALDPVTAINETGIKENDYFLLGCFELLENGGSHSKERTCVIGITKNDKKEDPIMRIAQGISSNFLYTEFTREITKWNKNRYYISNAIVDHLFNKMNFRSVIYPSVINNKRLNILLNEQAASDRLAFGYMYVCKMLEVNGTQFKAHIYKSLDDTTTKNELKWRKLDNQRLFTYKSEGPKDQVEVIKKRMCKHFE
>MIDB01000013|76892:89889|81236_81521_+|OHE43769.1|DBSCAN-SWA
MRKPKELHRFYKSKAWLVARNIKTNATQGKCERCGAIGEEVHHKIRLTVDNVNDTNISLNQDNLELLCRDCHNEEHERFKKKEVLFDSDGNFIV
>MIDB01000013|76892:89889|86771_87986_+|OHE43775.1|DBSCAN-SWA
MAIFKRKKKQGSVETFKFVNEINLPLTSFGNNISKSDVVKIAIDRIASQCAKLKPRYIKKANDKTVTEKSGKLSFILKHQPNEVMTPYQFIYMVITTLLMNDNAFIYPMFDGSTGEIKALYPLKPSIVEPIIDSGGSYYLKFSFDSTDSFTIPYENIIHIKRFYHTNQIFGGSSSKGDQEALLKTIQINENVLQGIDNALKSSMQIKGLLKMSAMLSETDKKKQLDSFNEILKESIRNKGSSIIPVDLKGDYVPLTTDPKLIDKDTLEFLQSKILDYFGVSVPIFHSKYTEDEFNSFYEQTIEPLAIQMSEAFSLGLLTQNEIMRGEEIIFYSERLQYASWNTKVTAIEKLMGLGIMSLNESRGLLGLEPVENGDRRLQSLNYVDATKANEYQVGKDDLNESNN
>MIDB01000013|76892:89889|80122_81271_+|OHE43768.1|DBSCAN-SWA
MKIITSESVFKGHPDKICDQISDAILDAHLEQDRNARVAVETAIKDDVVFIFGEVTSKASVNYKEVVLDTLKEIGYDDPFDVIEKISKQSDDIALGVNHTNDHEQGAGDQGLMFGYACKETPELMPLPIVVAHDIARSIDELRKAKYGHVFGPDGKCQVSVVYENDEPIAYETIVVSAQTKHGIQLDYAKEIILDEVLKPLIGEDLSHIQVLINPTGAFVVGGPYGDSGLTGRKIIVDTYGGYAKHGGGAFSGKDVSKVDRSAAYYARFVAKALVAANLADRCEVSVSYSIGVANPVSVSVDTFGTGVTSDEVLLKLIKENFNFTPSSIIKELNLDKVKFKPLAAYGHIGRVDLDVAWEQVDAKAKQLSESYEKTKRATQVL
>MIDB01000013|76892:89889|84231_85869_+|OHE43773.1|DBSCAN-SWA
MNYLIKYYDEIQKGNIIVGKELLTVLESLIKDIDNPRYIFDERPGNIRIEFIETFCKHTKSPFNGEPFILELWEKAILQAAYGFKMAETNLRRFNEVILLIARKNGKTTFIAGIDLAEFFLSKGGVDIVCASNTSEQANILFDEINNMREGSKALSNEKRSKKNIFHIYSPKTKNKIKKLSAQSRNKDGYNIEVGCIDEVHEMTDSKVYDAIKQSQSTKEEPLIFIITTEGNTVGGFLDSKLDYVRKMIKGEIDDERVLPWLYTQDSINEIYEDKNTWQKSNPSLGTVKTYSYLEDLMNKSRHDLATRVTMLCKDFNVKQLEQGSWLTYNDLNNEATYDINELRNSYAIGGVDLSSTTDLTVALLLLIKDGKKYVIPQFFMPSEVIKRRKEEDNVPYDIWVQRGLITVTEGNQNDFTLVTQWFLMMIRTYEIRPLWVGYDPWNSQYWTKEMEDLGFEMEKVRQGIYSLSEPMKQLEADLKNGNVIYNNNPIMKWNLSNTQAKIDINGNIQPSKLGSKYKRIDGAVALIIAYSVLNRYKIEYENML
>MIDB01000013|76892:89889|79769_80075_+|OHE43767.1|DBSCAN-SWA
MKVNFIRKPTPEELIPQDEFIVEKTIILESEVFEGFIRDPLNDYDFIKEHLELMYCDKEGIFHCLLVTSDKHDFGILVESEGYHYARYAAFIPLIKNKTEN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
OHE43762.1|76892_77417_+	hypothetical protein	A0A2K9V3J2	Faecalibacterium_phage	4.7e-07	31.1
OHE43763.1|77352_78564_+	lactate dehydrogenase	Q708N6	Streptococcus_phage	9.8e-101	48.4
OHE43764.1|78655_78982_+	hypothetical protein	NA	NA	NA	NA
OHE43765.1|78956_79394_+	hypothetical protein	NA	NA	NA	NA
OHE43766.1|79386_79773_+	hypothetical protein	U5JA61	Bacillus_phage	6.7e-11	33.6
OHE43767.1|79769_80075_+	hypothetical protein	NA	NA	NA	NA
OHE43768.1|80122_81271_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	7.4e-90	47.3
OHE43769.1|81236_81521_+	hypothetical protein	J9QDZ3	Clostridium_phage	9.9e-12	41.4
OHE43770.1|81560_82163_+	hypothetical protein	NA	NA	NA	NA
OHE43771.1|82253_83429_+	hypothetical protein	NA	NA	NA	NA
OHE43772.1|83908_84232_+	hypothetical protein	A0A290GJQ7	Caldibacillus_phage	5.2e-09	33.3
OHE43773.1|84231_85869_+	hypothetical protein	A0A290GJW3	Caldibacillus_phage	1.1e-110	41.0
OHE43774.1|85887_86754_+	hypothetical protein	NA	NA	NA	NA
OHE43775.1|86771_87986_+	hypothetical protein	A0A290G4I4	Caldibacillus_phage	7.2e-43	32.1
OHE43776.1|88761_89889_+	hypothetical protein	H7BUQ0	unidentified_phage	9.2e-61	46.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
MIDB01000013.1|OHE43765.1|78956_79394_+|hypothetical-protein	78956_79394_+	145 aa aa	AcrIIA11	NA	NA	76892-89889	NA

Protein sequences of MIDB01000013.1|OHE43765.1|78956_79394_+|hypothetical-protein

>MIDB01000013.1|OHE43765.1|78956_79394_+|hypothetical-protein
MMEKQQPLKDWIQAFNSGSFESSDVKVQIKAGWYDWFCKDSSLKNKTKRMGNIIKQIKPGGKVDLDNSYVWFKNNCPLQGSLYDDFRIADLESDVTLIVVQLNSPWHDKTYTVYERLTHYEKVVFSTDSVKELVKWLNEGWDTHV

anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome) information

• hit_Aca_id: anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome)
• identity: 1.0
• query_coverage: 1
• hit_coverage: 1.0

3. MIDB01000003

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	4828 : 13805	9	Staphylococcus_phage(50.0%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>MIDB01000003|4828:13805|DBSCAN-SWA
TATGCTTATGATAGAAGTGAAAAATCTGACAAAAGATTTCGGATATAATCGGGGGGTTTTTGATATATCCTTTGAAGTTAAAGAGGGTGAAGTATTCGGTTTTCTTGGTCCCAATGGTGCGGGGAAAACCACGACAATAAGAATGCTCATGGGTTTTTCTCAACCCGATAAAGGAACTGTATCCATTAACAGCAATGATTGTTGGAAAGATTACTCTTCGATATTGGGCGAAGTCGGTTATATTCCTGGTGAGGTTGCACTACCAGACGGACTGAGTGGACTTGAGTTCATCGATATGATGAAAAAAATGCGGCATGCAGAAGAGTCTAGGGTTACTTACTTACTGGATTTATTTGAATTGAATCCAAATCAGAGCATGAAAAAGATGTCCATAGGGGATAAGAGAAAGCTGGCAATTGTATCAGCCTTCATGTCGGATCCCAAAATTTTGATACTCGATGAACCAACCAGCGGCTTAGATCCTATCATGCAAAATAAATTTATCGAGTTAATCAAAACCGAGAAGAAAAGAGGGAAAACAATCCTTCTTTCAACTCATATATTTGAGGAAGTGGATGCCTGTTGTGATCGATTGTCGATTATCAAGGAAGGTAAAATCATTTCAACGATTGAGACTGATATCATTAGAAATAACGAAAACAAAGTCTTTAAAATTGAGTTTTTGGAAGATAAAGGATATGAGCAATTTATGAAATCGGATTTGAACATTATCTATAGCGATAAAACTAAAAAGAAGGTGAGAGTAGCAATCAACGATAAAGAGATAAATCGTTTGATTAAGGAAGTCTCTGACAATCAGGTGAAATATTTTTCAGAGTCACAATTTACGCTCGAAGACTATTTCCTAAATTACTATAAAGATAGCGAGGTTGAGTCATTCCTATGAGCATGATTGAAATTAGAAACCTGACAAAAGATTATGGATTATCACGAGGTATTTTCAACATCGATCTTGAAGTGAAAAAAGGTGAAATCTTTGGTTTTGTTGGAACTAACGGAAGTGGTAAAACAACAACGATCAGAAACATGATGGGTTTTATCAGACCGGATAGCGGAAGTGTCTACATAATGGATCATGAGGTGAACTATGACACAACTCAAATCATGAGACATATTGGATATGTGCCAGGCGAAATAGCTTTTCCCGACATAGGTGATGGGGATGCGTTCTTGAAGAGTCAAGCAGAAATGATGGGATTAAAAACCATGGAATACGCCAAGTATTTAATCAATAAATTTAAGCTAGACACCACAGCAAATCTAAAGCATATGAGCAAAGGCATGAAGCAAAAAACGGCCATCGTACAAGCGTTTATGGCTGAACCGGATATTTTAATCCTGGATGAGCCTTCAACCGGACTTGATCCACTCATGCGAGAAACATTCGTAGATGTATTGATGGAGGCAAGACAGAGAGGTGCTACCATATTTATGAGCAGTCATGTGTTTGAAGAGGTAGAAAAAACATGTGATCGTGTCGCACTTTTGCATAACGGGAAAGTATTAGATATCGTGGATATGAAAAAGATTCGTCACAACGAAGTAAAGACATACAAAGTTGGATTTGAAGACGAAAGAGATTATCAAAATTATGTGAATTTGAATCTCTACATAACGTCAAAAAATGATAAATATATGCAAGTAACCGTCGACATCAAAGACGCTCAAGTAAACGAATTTATGAAGGTATTAGCGCAATTCAATTTAAAATATATCAAAGAAGTAAAATACACGCTCAAAAAGTATTTTTTAAAAAAAATAAGTGAGGACAACGAAAAATGATCAGTATACCATTATTGAAACAATCCATCAAAGCGAATTGGGGTCTTTGGACAGCAACAACCCTGACATTGATTTTGCTTTACGTCGTTATCAAATTTGCTATGGGGTTAGTCACGGTTTCAGGTGATGCAGACCCAAACATATTGATCCCATATATCATCGCCTTAGAATCCGCAGGGCTGTCACTCGACGGACTCTTTACTGCGATCGGTTTGAATCCTGACATCTTGACAGGCATTGCATCGATGGATTCAAATGTTCTGGTTAGCTCAATTTTTTATCCTGTTGTGTCGGTGCTGATGCCCTTGGTCTACACGGTTATAGTTGGGAATAAATTGTTTGCCAGTCAAATTGATCGAGGATCCATGGCGTTTGTTTTATCCACTTCGATCAAGCGATCCAAGATAGCGTTCACGCAAATGTTCTTTTTCATCATGTCTTTAGTAGCGATGTTTATCTTAACAACCATCGTGGATGTTATCTTAGCATTAACCATCGAAAATTCATTAGCGATTGACCACGTTCTGTTGCTCAACCTAGGTCTATTCATATTCACGGTTGCCATGGGATCGATTACGTTCATGTTTTCTGCGGTTTTCAACTATACGAAGCATTCGATCTCTTTAGGTGGAGGTGTAGCGTTAGTATTTTTCATATCTAAAATATTAGGGTTGTTTGGTTCTGATCTCTTCATGAACATGGGGATTGGTATCGAGCCCATGGGATACTTTAATAACATCACGATGATCACGCTGTTCAATACGACCTCAATCTTGGATGGGTCATCCACCTACATCATGCACTTTGCAATTCTGTTACTCATTTCAGCGATGTGCTTTACAGTAGGCACGCTTTGGTTTACAAAAAAAGATATTCCAGTTTAAGGATCGTGCATAGTAGGATATCATGAAGGAGGGATGCAATCAGTGAAAAAAATAATTATCTTTGATTTGGATGGAACTTTGAGCAACAATGTCGATCAGTCTGAACTCATATATGAACGAATTTCAAAACGATACAAACTAAAACAACTATCCAAAGATGGAATTCGAGAATTAAAAACGAAGCCAGGTTTAAAGCGGTTGTTCGATTTAGGTGTTCCGATATATAAATTGCCTAAATTGTACAGAGAATCGCGTGATATTGCATCTGAATTTGTCGATGATTGCACGATCATCTCAGGAATGAAAGAGCTCTTAGTGAACCTGAATGAAAGCAAGGTTAAATTAGCCATCGTTTCTTCAAATAGTGTTTCAAATATCAATAAAATATTATCAAATAATGATATCAACACATTCTCCTTCATTGAGGGGAAGGCTAGCATGAAAGGAAAAAAACGCAAGATTAAGAAACTGCTTCGAAAACATGGATATGATCCCGAGGACGCCATTTACGTCGGTGATGAAATTCGAGATGTCTTGGCTTGCCGATCAATTCCCATCGAAGTGATCGCGGTGACATGGGGATTTGAGACGAAAAACGCTCTGGCAAACTCAAATCCCGATTACATTGTCGAGACGATTGAAGAATTATCCAGTTTGCTGATGAATAAAACTGGTGGTCATCGAATCATTAAGAATCGCAGTAGAAAGGTAGAGAAACCATGAGAAAAAGAATCGTGATTGACACTTCAACAGGCGGATTAGATTATTATCCATTTGAACATGGCATTGAGATATTGCGTATTAAGATCAATATCAAAGGTCAAGAGTATGAGGACGGATTAACACTAAAGGCAGATCAATTTTATGATATGCTTAAAAACGATAAAGAACTATTACCAAAGACCAGCCAACCATCTGTTGGCGATGTGATGAACATCTTTCAAAAATTCTTAGATGAAGGTGTTGAAGAGATTTTTGTAGTGACCATATCGGCTAAGATGAGCGGAACTTATAACTCATGCATCATGGCTGCTAAGGAGTTCGAAGGGAAAATAAAGATTAAGGTCTTTGATACGAAGACGGTCTGCTTTTCGGAAGGTATTTTCGCTTTGGAAGCTAAAAAGATGATCGACAAAGATTTTTCATTAGAAGAAATCGAAAACAAACTCAGTGACATGAGACATTTGAACACCATCTATTTTGCAGTAAACTCTTTAACCTATCTGGTTAAAAATGGACGCTTGAGCAATGCGAAGGGCTACATAGGCAAACTTTTAGATATCAAACCGGTGTTACAGGTGCAAGAATCTGGGGAAATCGTTTCAATTGGCAACAAACGAACCATCAAATCCGTCCTATCTTCAATCACATCGTTGGTCGAAGAATATGTCGATCATCGTCCATATCAGGCATATTTAATCTATACAGCGAACCCTAACCTGAAAGCTCATTTCGTTAGTATGATTAAAGAAAATCTCGGATTAGAAAACCTGTATGAATCACCGTCGACTCCGGTGGTTGGTGCACATGTCGGTCCTGACGTGATAGGCATTGGGATTTTTATTGGTGATCATTTAGAGGTAGGTAGGAAAAATTGATGAAAGAAAACATACAGGTTACTAGAAGCAAAGAGTGGATATATAATGCACTCATGTTCTTACTTAAAAAAAATGCTTTTAGAAAGATATCTATTGATGATATTACAAAAGAAGCAGGTGTTGCAAGACCGACATTTTACCGCAACTTTGATTCGAAAGAAGATATATTGCTCGATCAAGGACGAAAAATATATGAACGTTTAATGTTGGATCTTGAAACGGACATGAATAATGACAATCCAATTTTCCATTCGATTAAGAAAATGGTCATAGTTTTCAATGAGTATTCCGATTTAATCGAAGTACTCATCACCAACAGCCTAGAATATCTTATCTTCCAGTCCTTTGAAGCTGAAATTTCAAAATTATTGAAAAAAGTATTTGATATTGAAAAGGAAGATAAATATAAAGCACGGTTTTTTGAAGGTGCACTGTTTTCTGTTGTGGTTGAATGGATTAAAAATTCAAAGTCTGAATCCGTTGACGAAATGACTGAGATTATATATAATCTTGTCACATTTAATAACACCTTGTAATGAATTGACCAGTAGATCGACGGCGGATTATAGATCAATCGTACAATTTTTAGTGGGATCAGCACTAATATTTAATAGCTATACTGACTTCAATTATTGATTACTTCAATCCATTTTGATAAACAAACTCGCAAGAAGTTGTATAGATTTTGAGATGAAAACCTATTGTTTGTGAAAGGAAAAAAATGTGAATAAATTAGGAATTTGTTTATCTGGTGGAGGCGCAAGAGGAGCATATCAAATCGGTGCGCTAAAAGCGCTTGAAGAACTGGGCATTTTACAAAAAGCGAGTGCGTTTTCTGGAGCTTCGATTGGAGCGGTTAATGTTACTTTTGCAGCCATTGGTTCACTTGATTTAGCAATGGATATTTGGTTCAACGTTCCAGAAGCGCCACTGGGAGAAAAAACTGCAATTATAAAGACCATCAAGAACGAGAGATTAAGATTAATTGATAATGGTTTGTTATCAATTAATAAGTTGAATGAGTATTTAAATGAGTATTTGAATTTTGAACTATTGACAAATAAAGATATCTATATTGCAGTCTCTGAAACCGGTGATACTGATAAAGGATTTACTGACTTGTTGAAGTCTACCATTAAGCATTACGTTCATAGAGAATCACAAGTATCGTATGTACCACTTAAAGAGCTAGATAAAAATATGCAAATCAATACGCTTGTTGCCTCGTGCTCAATACCCATAGTGTTTCCACCTGTTATCACTAACAATAAAAAATATAGGGATGGAGGGTATTTCGATAACACCCCAGTTCAACCACTAATTGATATCGGTTGTGATGAAATCATCTGTGTCACTGTTTCAGCATTATCCTCATTGCGATCGAAAAAAAAGAAGTATAAGAATGTTAGAATACATGATATACGATCAACAAAAAGTTTAGGTAAAATACTTGATTTTACATCTATGCACTCAAGAAGAATTTATCATTATGGATATGACGATGTCATGAATTATTTCAAAGACAAAAAAAGTGAATGAAAGCTGTTGTTGAAATGCTTGAATCGACAATTGGTTTAAACATTCGAGTTTAGATATGATGAAGCAGGTGAATATGAAGCAAAGATTAGTAATAGGAATTTTTACAGATGTATTTTTTCCAATGATTGATGGAGTGGTCAATGTCGTTGATAACTATGCAAAAAAGCTATCTTTGACCGCAGATGTCTATGTTTTTTCACCTAATTATGGAGAAATAGAGAACATTGATAAATTTGCATATAAGGTTATACGGACAAAGTCTATAAAATTGCCACTGATGGATTACAGGCTTTCGTTTCCAAGTTTTGATACTTTTTTTGAAAAGAGCATGAAAGCAATAAAATTTGATATCATACATATTCACAGTCCATTTTCAGTAGGTAATTATGGGATTAATTATGCAAAAAGGCATAATATTCCACTTATCGCAACATTGCACAGTCAGTATAAAAAAGATTTCTACGAGCGTAGTAAAAATGCATTTATCAGTGAACTCGCAATCGGTGAATTGATGAGGAGATTAAACAGATGCGATCGACTCATTGCAGTAAACGATGAAATTGCAAGAGTATTTTACGAGTATGGTGCGAAAAGTCTTCCTATAGTCATCCGCAATGGGACTGACTTATTGCCCTTGGAAGATGAACAGATGGCTAATGATTTGAGAAAGATGCATCACATTCAGCATGAGGATAAAGTGCTTTTATATGTTGGCCGCTTAGACAAAATCAAAAATGTAGATTTTTTAATCGATTCTTTGACGATTCTTAAGAAAAGAGAGTTCAAATTTAAAATGATCTTTGTTGGATCTGGAATACATGAAGGTTTTATGAAGAAAAGAGTCACTTTAAATAATCTTAATGAGAACACAATATTTACAGGTCGTATTAAAGATCGAATTGAATTATCATCTTACTACAAAGTAGCAGACCTTTTCTTATTGCCATCATTATATGATGCTTCATCATTGGTTCAGGTTGAAGCAGCTAGTCAGCATACACCTACCTTATTTATAGAAAAAGCAGTAACAGCTAGCACTATTTGTGATGGAGTAAATGGATACCTCTCAAGCAATGCACCTGAAATGTATGCAGAAAAAATAATTGACATATTTAGTAAAGCTATATCACACAGGGAAATATGTAATAATGCTTACAGAGATCTATATCTATCGTGGAATCAAATCGTCAATGAATTATACAAAAACTACATTGATTTGATATCAGAAAAGTTAAATACAGTTAAAATGCATAAAGACTGATAACTGCTTATCTACACATAGCAATCTAAACACTGGTAATGAAAGTTCCGAAATACACAATGCTTGACATTCTTGTCAATAAAAGCCATCAGATGACCTTCATAGGTTTCGATGGCTTTTTTTCGATGAGTCAGATTTTATTCATCTTCGCAACATATTTTGCTTCAAAAAAAATTAGATAATAACGACTTTGTAATTCATAATTTTACCGTACTTTTCGTTATGATAAGTACCTGTTGCTAAAGGTTTTAGTGCTTCAAAAGTATGTCTATTTTCTGAGAATTCTTTATCGGTATAATTCTTGGTTCCTGCTACACAGAAGACAATGTTTTCAGGTGTCACTGAGATGATCTTGTAAATGAATGAACGTAATGTATCACTATCAACTTCCTGGATTGGTTCTAGTAAATTGTTGAGTGTGGTTTCTATCTTTGCAAGTCTTGATCGCGTATCGTAGTTCGTTAAGTACTCACCTTCAAGTTTTCTGATCTCGGTTTTGTTATTGTGAAGCTGCAAGGTCAGTGATTGGTATTTGCTGTTGAAATCCTCCTGGGAAAGATTAGGATTCTTCACTTGAACATCAATTAGGTTTGATATCATTCTTTCAAGCTCATCGCCTTGTGTTTGAAGCTTTTGAATCTTGATTTCAACATCGCTAACTCGAATGGTCGACTTGATGATTTTCTGTATGTTTGGGATGATATCCTTTTCCTGTAAAAACACCTCGTTGAGCATTTTCACAGTCGCACCTTCAATCATCTCTTGGTAAGTAGCTTTAGCCTTACAGTGGGCTTTACCGTCGATGTAACCACCACATTGTTGCATAACTCTTTGAGCTGGTGTACCGTAATTCCAATAGCGTCTTTTCAAGGTTCGTCCACATTCAGAACAAACGATAAATGCTGAGAATGGATAAGTGACATTGTATTTGGCCAGGTTCTTATCCTTACCAACTTTCACCTTGCTTCGATCCTCTCTGATCCTTTGAGCAAGGAGAAAAGTCTCTCTATCGATGATTGCTTCGTGTGCATTCTCGGTATGATACATTGGAGCGAGTTCTTTATTCTTCACTTTCTTATGTGAAAGGTAATCAACCGTCAGTGTTTTCTGTTGAACCAAATCGCCGATGTATTTTTCGTTCTTAAGAATAACTGCGACTGTGGACATACTCCATTTGGTTGCACCAGCACCTGTAGTTGCTCCTATGGATTCCATATGTTTAGCAATCTTCATCGGACCGATGCCACTCACATACATTTGGAAGATTTCACGGACGATTTTAGCTTCTTCAGGAACAACGATTAGGTTACCACCTCGTTTGTCTTTGGTATAACCTAAGAACCGATTGTGATTCACAATTGGAACGCTATTGTTGAAACGCTTTTGAACATTCCATTTGACGTTCTCGCTCACGTTTCTTGCTTCCTCTTGGGCGATGGATGACATGATGGTTAATAAGAAGTCCACTTTTGGATCTGAGGAGTAGATGTTTTCTTTTTCAAAGAAGATCTCAACATTGATTGCTCTCATCTCTCTGATGTAGTTTAAGCAATCAACTGTATTTCTAGCGAATCGTGAGATTGACTTCGTCATGATCAAATCGATTTCACCACGCTTTGCAGCATCCATCATATTATTGAACTGTTTTCTGTGCTTGGTGGAAGTTCCGCTGATGCCCTCGTCTGCATAGATACCACAGAATGTCCATTCAGGGTTATTTTGAATCCTTTCGGTGTATTCGTCGGTTTGAGCGATGTAACTCGTTTTCTGTTCCTCATTATCGGTGGACACTCGAACGTAGGCACACACGCGCTTTTTGAGGTTCTTGGGGATGGTTCCTGATAAATCGAACACAGGTTTTGGTTGTATGACTCTGACTTGTTTGTTTTGCAT

Protein sequences of DBSCAN-SWA_1

>MIDB01000003|4828:13805|9111_9648_+|OHE45218.1|DBSCAN-SWA
MKENIQVTRSKEWIYNALMFLLKKNAFRKISIDDITKEAGVARPTFYRNFDSKEDILLDQGRKIYERLMLDLETDMNNDNPIFHSIKKMVIVFNEYSDLIEVLITNSLEYLIFQSFEAEISKLLKKVFDIEKEDKYKARFFEGALFSVVVEWIKNSKSESVDEMTEIIYNLVTFNNTL
>MIDB01000003|4828:13805|6626_7514_+|OHE45215.1|DBSCAN-SWA
MISIPLLKQSIKANWGLWTATTLTLILLYVVIKFAMGLVTVSGDADPNILIPYIIALESAGLSLDGLFTAIGLNPDILTGIASMDSNVLVSSIFYPVVSVLMPLVYTVIVGNKLFASQIDRGSMAFVLSTSIKRSKIAFTQMFFFIMSLVAMFILTTIVDVILALTIENSLAIDHVLLLNLGLFIFTVAMGSITFMFSAVFNYTKHSISLGGGVALVFFISKILGLFGSDLFMNMGIGIEPMGYFNNITMITLFNTTSILDGSSTYIMHFAILLLISAMCFTVGTLWFTKKDIPV
>MIDB01000003|4828:13805|5730_6630_+|OHE45214.1|DBSCAN-SWA
MSMIEIRNLTKDYGLSRGIFNIDLEVKKGEIFGFVGTNGSGKTTTIRNMMGFIRPDSGSVYIMDHEVNYDTTQIMRHIGYVPGEIAFPDIGDGDAFLKSQAEMMGLKTMEYAKYLINKFKLDTTANLKHMSKGMKQKTAIVQAFMAEPDILILDEPSTGLDPLMRETFVDVLMEARQRGATIFMSSHVFEEVEKTCDRVALLHNGKVLDIVDMKKIRHNEVKTYKVGFEDERDYQNYVNLNLYITSKNDKYMQVTVDIKDAQVNEFMKVLAQFNLKYIKEVKYTLKKYFLKKISEDNEK
>MIDB01000003|4828:13805|4828_5734_+|OHE45213.1|DBSCAN-SWA
MLMIEVKNLTKDFGYNRGVFDISFEVKEGEVFGFLGPNGAGKTTTIRMLMGFSQPDKGTVSINSNDCWKDYSSILGEVGYIPGEVALPDGLSGLEFIDMMKKMRHAEESRVTYLLDLFELNPNQSMKKMSIGDKRKLAIVSAFMSDPKILILDEPTSGLDPIMQNKFIELIKTEKKRGKTILLSTHIFEEVDACCDRLSIIKEGKIISTIETDIIRNNENKVFKIEFLEDKGYEQFMKSDLNIIYSDKTKKKVRVAINDKEINRLIKEVSDNQVKYFSESQFTLEDYFLNYYKDSEVESFL
>MIDB01000003|4828:13805|7547_8237_+|OHE45216.1|DBSCAN-SWA
MQSVKKIIIFDLDGTLSNNVDQSELIYERISKRYKLKQLSKDGIRELKTKPGLKRLFDLGVPIYKLPKLYRESRDIASEFVDDCTIISGMKELLVNLNESKVKLAIVSSNSVSNINKILSNNDINTFSFIEGKASMKGKKRKIKKLLRKHGYDPEDAIYVGDEIRDVLACRSIPIEVIAVTWGFETKNALANSNPDYIVETIEELSSLLMNKTGGHRIIKNRSRKVEKP
>MIDB01000003|4828:13805|9835_10651_+|OHE45219.1|DBSCAN-SWA
MNKLGICLSGGGARGAYQIGALKALEELGILQKASAFSGASIGAVNVTFAAIGSLDLAMDIWFNVPEAPLGEKTAIIKTIKNERLRLIDNGLLSINKLNEYLNEYLNFELLTNKDIYIAVSETGDTDKGFTDLLKSTIKHYVHRESQVSYVPLKELDKNMQINTLVASCSIPIVFPPVITNNKKYRDGGYFDNTPVQPLIDIGCDEIICVTVSALSSLRSKKKKYKNVRIHDIRSTKSLGKILDFTSMHSRRIYHYGYDDVMNYFKDKKSE
>MIDB01000003|4828:13805|12086_13805_-|OHE45221.1|DBSCAN-SWA
MQNKQVRVIQPKPVFDLSGTIPKNLKKRVCAYVRVSTDNEEQKTSYIAQTDEYTERIQNNPEWTFCGIYADEGISGTSTKHRKQFNNMMDAAKRGEIDLIMTKSISRFARNTVDCLNYIREMRAINVEIFFEKENIYSSDPKVDFLLTIMSSIAQEEARNVSENVKWNVQKRFNNSVPIVNHNRFLGYTKDKRGGNLIVVPEEAKIVREIFQMYVSGIGPMKIAKHMESIGATTGAGATKWSMSTVAVILKNEKYIGDLVQQKTLTVDYLSHKKVKNKELAPMYHTENAHEAIIDRETFLLAQRIREDRSKVKVGKDKNLAKYNVTYPFSAFIVCSECGRTLKRRYWNYGTPAQRVMQQCGGYIDGKAHCKAKATYQEMIEGATVKMLNEVFLQEKDIIPNIQKIIKSTIRVSDVEIKIQKLQTQGDELERMISNLIDVQVKNPNLSQEDFNSKYQSLTLQLHNNKTEIRKLEGEYLTNYDTRSRLAKIETTLNNLLEPIQEVDSDTLRSFIYKIISVTPENIVFCVAGTKNYTDKEFSENRHTFEALKPLATGTYHNEKYGKIMNYKVVII
>MIDB01000003|4828:13805|8233_9112_+|OHE45217.1|DBSCAN-SWA
MRKRIVIDTSTGGLDYYPFEHGIEILRIKINIKGQEYEDGLTLKADQFYDMLKNDKELLPKTSQPSVGDVMNIFQKFLDEGVEEIFVVTISAKMSGTYNSCIMAAKEFEGKIKIKVFDTKTVCFSEGIFALEAKKMIDKDFSLEEIENKLSDMRHLNTIYFAVNSLTYLVKNGRLSNAKGYIGKLLDIKPVLQVQESGEIVSIGNKRTIKSVLSSITSLVEEYVDHRPYQAYLIYTANPNLKAHFVSMIKENLGLENLYESPSTPVVGAHVGPDVIGIGIFIGDHLEVGRKN
>MIDB01000003|4828:13805|10724_11912_+|OHE45220.1|DBSCAN-SWA
MKQRLVIGIFTDVFFPMIDGVVNVVDNYAKKLSLTADVYVFSPNYGEIENIDKFAYKVIRTKSIKLPLMDYRLSFPSFDTFFEKSMKAIKFDIIHIHSPFSVGNYGINYAKRHNIPLIATLHSQYKKDFYERSKNAFISELAIGELMRRLNRCDRLIAVNDEIARVFYEYGAKSLPIVIRNGTDLLPLEDEQMANDLRKMHHIQHEDKVLLYVGRLDKIKNVDFLIDSLTILKKREFKFKMIFVGSGIHEGFMKKRVTLNNLNENTIFTGRIKDRIELSSYYKVADLFLLPSLYDASSLVQVEAASQHTPTLFIEKAVTASTICDGVNGYLSSNAPEMYAEKIIDIFSKAISHREICNNAYRDLYLSWNQIVNELYKNYIDLISEKLNTVKMHKD

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
OHE45213.1|4828_5734_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.7e-23	30.4
OHE45214.1|5730_6630_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	7.0e-19	25.6
OHE45215.1|6626_7514_+	hypothetical protein	NA	NA	NA	NA
OHE45216.1|7547_8237_+	hypothetical protein	NA	NA	NA	NA
OHE45217.1|8233_9112_+	hypothetical protein	A0A0N9SI50	Staphylococcus_phage	6.8e-11	29.8
OHE45218.1|9111_9648_+	hypothetical protein	A0A1X9I6A2	Streptococcus_phage	1.4e-06	45.8
OHE45219.1|9835_10651_+	hypothetical protein	A0A1V0SCF5	Indivirus	6.6e-08	31.0
OHE45220.1|10724_11912_+	hypothetical protein	NA	NA	NA	NA
OHE45221.1|12086_13805_-	hypothetical protein	A0A2K5B2B4	Erysipelothrix_phage	1.0e-90	41.5

4. MIDB01000008

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1621 : 18180	16	Caldibacillus_phage(20.0%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>MIDB01000008|1621:18180|DBSCAN-SWA
ATTATAGCATATTTTCGTAATCTATCTTATACCTATTAAGAACTGCATAAGCAATAATCAAAGCTACTGTTCCATCAATTCGCTTGTATTTGGAGTTAAGTTTCGAAGGTTGAATATTGCCATTTAAGTCAACTTTGGCTTGGGTGTTAGACAAACACCATTTCAAGATCGGATTATTGTCGTAGTTGATAAGCTTATTCTTTAGGTCTGCTTCCAGTTGTTTCATTGGTTCCGATAAAGAGTAGACACCTTGACGAACCTTCTCCATATTAAATCCTAGCTCTTCCATTTCTTTAATCCAATATTGAGAATTCCAGGGGTCGAATCCTACCCAGAGAGGTCTAATTTGGTGCTCTTGAATCATCTTCATAAACCATTGAGTCACCAATGAAAAATCATTTTGACTGCCTTCAGTTAGTGTAATAAAACCTCTTCTAATCCATATATCATACGGGACATTGTCTTCTTCCATACGTTTCTTAACAACATCACTCGGCATAAAGAAATGTGATAACACATACTTCTTGTTGTCATCCTTCTTCTGAATGATTAGGATTGCTGCTGTTAGGTCAGTTGTTGATGATAAATCGACACCAGCAATTGCATATGAATTCTTCAGAGTGCTTAGTTCATACTTAGCTTCATTGTTTAAATCATCAAAAGATAACCATGCACCTTGATCGACTTGCTTGATATTGAAATCCTTACATAACATAGTCACTCTTGTTGAGTGGTCATTTTTTGATTTGTTCATCACATCTTCGAGATACGAGGAGAGTTTTACCACACCTAAACTGGGATTAGATTTCACCCAATTCTTAGGGTCATCATATATTTCTTGCGTGTTATCTTGGGTATATAACCAGGGAAGTACACGTTCGTCAGTGATTTCACCTTTCAGCATCTTTCTTGCATAGTCTAATTTGTTATCGAGGAATCCACCCACTGTGGTTCCTTCGGTTGTGATGATGAAGATTAGTGGTTCCTTTTTTGTTGATTGGCTCTGCTTGATGGCATCATATACTTTTGAATCAGTCATCTCATGCACTTCATCAATACAACCCACTTCAATGTTATAACCATCTTTGTTTCTACTTTGTGCAGATAATTTCTTAATCTTGTTCTTTGTTTTCGGAGAATAGATGAAGAATATATTCTTTTTACTACGTTTCTCATTTGATAGAGTAGGTGACTGTTCACGCATGTTATTGATTTCTTCAAAGAGAATGTTCGCTTGCTCACTCGTGTTTGAAGCACATACGATATCAACTCCACCTTTGGAAAGAAAGAATTCAGCAAGGTCAATCCCAGCGATGAAGGTTGTCTTTCCATTCTTACGTGCAATCAGTAATATGACTTCATTAAATCGTCTTAATCCAGACTCAGCAATCTTAAACCCATAGGCAGTTTGAATGATTGCTTTTTCCCAAAGTTCTAAAATGAATGGTTGTCCATTGAATGGGGACTTCGTATGCTTGCAGAAGGTTTCGATAAAATCGATTCTCATGTTTCCTGGCTTTTCATCAAAGTCGTATCGAGGATTAACCATATCATCCATCAGTTTTCGAAGAGTGCTCTTTAATTCCTCTCCAGCTAGTATTTCATTGGACATCACTTTCTGGTAGTACTCAATTAAATAGTTCATGCCATATTCGCCTTCTTGAGAAACTCATCAAACGCATCATCGCCATCAATTACGTTCTTTCCCATGATTGAATTGAGTGTTTTGATAACTGTTCCATACGAGTTGATAAGTTTAGTGTAGTACTTAGCTGCTTCTGTTTGTCTTTGAGCACCTTTGCTTGAAACTTGAACAGCTCCATACTTCCTTATCTGTTCTTGAAGGACCCCAAGTTCAACCTTCATAAATGCAGCCTGCTCAATAAGGTTATCGACTAGTTGGGTTTTGGTCTCATCGACCGATGAAAAAAGCGACCGAAGTCGCTCAATCTCAATATTCACATCTTTTATTTTAGACATTTCAGTTCCTCACTCAGTTGACTCTTTCAACTACCTCAGAGTTTATGACTTCAATCAAATCTTCTTCTGGAATGATTGCTAATCCACCCCAAGTTCCATGTAGTTGATCAAGTCCATCTATGTATTCGATGACTCCTTCACGACCGTTGTAATGGTCTTCACCCTTCATGTTAATGATTCTAATTTTATCTCCAATTTTATACACACCGATTACCTCCAATGATTAGTAATATAAATCACTCTAAAGAGGACAAATAGCAAGTAAAAAAGCCACTTAAGTGACTTTATTTTGACAAACCATAGTTTTGCTTTTCTCTTTTTACTACCACTAGATAAAACATTTCGAGTTGATGCTTCATTTCATAAAGTACATTCAATTTGTAAAAAAGTTTAAGACACAAGACTCCAAATTCAACAAAATATAATGAGTTAATTCTCTCTTTATCTTTGTTTTTATCAATGAAGTTAATCCTCTGATTAATCACATCCATGTTAAACGTCCTATGAGCAATCGCATTGCGTATGTTATTGTTCACTACGGATTTATATGTGTGTCCAAATACTTCTGAACCATTTACAAGTTGATTTACTTTATTATATTTTGATCCCACACTATTAACTGTTTCATCAAAATCAAAGCCTTTTCTATTACTAAAAGAATCATACTTCTGTCTATGCATAATATTGTTTATTCCTATTATTAGGTCGCAATGATCACAATATGTTTCGTACATATTCATGTAGAAATCAACTAGATTTTCATAAGATACAGTAGTTACTCCAAGCTCGTTAAGGTCAAAACGATCAATGATTTCATAATTATTTACGATCGGGATTAAAAGCGGAAACAAATCAATAAACTCTTCAGTTAACTTCAAGATTTTGATATCAAAGTCTAGAAACTTGTTTTTTCCATACAAATAACTACTGAAACGTGCAATTTCAGGATAAAGAAACGTTTTCCCATGGACGGTGATGCGGACTTTATCAGCCTCGATAAAAGTTTGCTTGTTTATTAATCCACTTAACCAATATTTTCTTGCGTGATGAAGAATTAATCTAGCATCAATTCTTGATTTAGCAGCATATATATAATCTCCACTTTTTAGAATACTAGTATAAGGATCATCCTTTTCAAGATTCTGAATCAAAATATCAATCTTATTATTAATCCAAAGATTATTCAAATTTTTCATAGAATTTTTCATCCTTAAAAGATCATCATACGATTTATGAAGTGATTGAAGATTCAACACAGATTCTTCACCACCCAACATCATCATCCTTAAAAATGGTGTTATATCAGGTATATCGTCATCTTTACGAAGTTTTCTCTGAAAAAATTCTGCAGATAATTCGGCAACATAGATAGGTTTGTCATTTGATTTATGAACATTTTTTATCTGATACTGAAACCATTCGTTTTGATCTAAACTAAGGGGTCCATCATCATTTGGAATTCTAATTGTTCCACTTATTAGTGTTGAACAAACAGGACAATGTATATTCACAGGAATATCATAATGATCCACCTGAAATCTCAATCTAATAGGTGTATTGCATATTGAGCAATTACAAATGTAATTATGCACCATCAAAAATCACTTCCTCACTTTAACATTTTCAAAAATTTTGCCTTCCATTTTTTGTTTGCCACCCTGTACGGTACCCTTTTGAATTACTCATAATTAAGAAGGGGGGGATCAATTTAATGCACTAATTCTTAATTTCATTGTTTGAATATAAATATTTTTCTTCTTAATCTCATCACTGTTATTTGGAACTATTTCATTGAATCTATCTATCAAATAATTCAACGAGTTTATGTATGTGTTTTTATTTCTCAGTAATCCTAATGCTTCTAAATCAGCAGAATGTTCATTTTGATTTACAATATTAGCTAGGGCTTCCTGTTCTTTATCTTCATATGATTGTAATGGGAATTTTTTTCCTTTAATCTCAGAAACAATATGACCTAATTCATGTGCTATGTAACATCTATATTTCTGGTCATTAATCTTCATGTAGCATTCATAATCAAACATGATAATGTATTCATCATCCTTTTTTGTTTCTGCAATGAAAGGAATAACGGTTTCATCTTCAGTATCTTCTTTAACCGCAAGCACGACACAAATATCATTGTATTCCAAATAACCAATCTCTAGTACATTGAACTTAGAATCTTCAGATTCCTTAATTTCGAATATTCTTTGAAATTCATTTCTAAATTTTACTTTAATTGGACCTATATTAAAATCCAACCTCTTTTTTTGTGGTTGCATGATTTCACCTGCTTTTATAAACATTATATCAAAAAATGTTTACTTTAATTAGGTTTTTCTGGATTTATTAGGTTGCCATCTACATCAAATCGAATCTTATTATTGAATCTGTCATGTTCCTTATTATGGCATTCTCTACAAAGTAATTCCAAGTTCTCTTGATTAAAACTAATCGATGAGTCATTAACATTCTCAATGGTCAGTCTTTCTTTGTGGTGAACTTCGATTCCGATTTGTCCACATCGCTCACAAAGCCCATTTACTGACATTATTTTTATTTCACGAGCAGCTAGCCATGCGGGTGACTTATAGAAGTTATGCAGAACCTTTGGCTTTTTCATATGCTTCTTTTAGCTCTGCTGCTTTTGCTTCTACATGCTCCCATCGGACAGGTAAATCTTCGCGACCCATGTGTCCATAGGCTGCTAACTTTTGAAACTTCACTGTTTCAAACTCTAGTTCTTTCCTAATGTTTCCTGGTGTGAAGTTAAAGTATTGTTTAACCAACTCAAGCAAGTCTTCATCGGATAATTTCCCAGTTCCTAAGGTATCGATCGAGACAGCGATTGGATTTGCTACTCCAATGGAATAGGACACACAAACTTCGCACGTGTCGGCCAATTCTGCCGCTACAACGGCTTTTGCTACATATCTGGCATAATAACTCGCACTGCGATCAACCTTGCTTACGTCCTTACCAGAAAAGGCACCACCACCATGCTTTGCATATCCACCATAAGTATCTACGATTATCTTTCTGCCAGTTAATCCTGAATCACCATAAGGACCACCAATGATGAATGCACCTGTAGGATTAATTAGAACATTGATACTAGTCAGATCCTTGCTGATCATTGGTTTGAGTACTTCCTCAATAATGATTTCTTTTGCGAGTGATAGGCTTGCTCCTGGTCTTGTTTGGGCTGAAACAATAATCGTGTCGTATGCAAAAGGTTGACCATCTACATATCTTACCGATACTTGGCACTTACCATCTGGACCAAAGATGTGGTTGTACTTAGCTTTTCTAAGTGCATCTACTTCTTTAGCAATCTCATGTGCAACTACAATCGGAAGTGGCATGAGCTCAGGAGTTTCATTGCATGCAAAACCATACATCATCCCCTGATCACCAGCACCCTGTTGATGATCTAGCGTTTCATTGACACCCTGTGCAATGTCTGGTGATTGTTTGGATATCTTTTCTAGGACACAAAACGTATCGTCATATCCGATGTCCTTGAGTACTTGTTTTGCAATATCTGAGTATTGAACGTTAGCTGTTGTTGTTACCTCTCCAAAGATAACAACTAAGTCATCTTTGATAGCTGTTTCAACTGCTACTCTTGCTGATTGATCTTGTTCAAAAATGGCATCCAGTATTGCATCACTGATTTGGTCACAGATTTTATCTGGATGTCCACTAAAGACCGATTCGCTTGTTATGATTTTCATGTTGTCCTCTTTTCTAGCAAGAAAAAGGAAGCACTTAGCCTCCTTGGTCTGCTTTGATTTGACTGTGTTATTTTATTGCTGCTTTTGGTAAGTATGCAGTGTACCTTGCGTAATGATATCCTTCGCTTTCGACTAAAATACCAAAATCGTGTGAATCAGATGTAACGAAGATACAGTGAAATACTTCTTCTTGGTCACAGTACATATGCTCTAGATTTTCTTTGATGAAATCGTAGTCATTCAGTGGATCCTTGATGAAGCATTCAAATAAATCTTTATCAATGACCACTTGTTTATCAATAACAAACTCATCATTAGGTATGAGTTCTGTTGATGTTGCTTTGCGTATAAAATTTGTTTTCATATTGTTGTCCTTCTAGTCGATTTTCCAAGCGGTATAGACGCTTCGGTAAGTGCAATCCCAAGTATCTAGAATAACGCCATCTTTACATACTGTAACATGGCCAGTCATCTTCAAAACATATGTCCCGCGCGTATAGAGACCGGTAAAAGTGGAACCCTTGATTCGAGGTTCTCCCTTGATTGCTTTAAAGATCAACCGAGGTTTTCCTTCGAAGTATTTGTACAAAAACTCAGTATCTTTATAACTTGTGAACTTCCATTCTCGTTTGAGTTGATTGAGTTCTCGTCTGCATTCCATGTAGTCTTTATTCATGGCTGTGCTAATCGCTCTTACCACACAGTCAGTTGTTTTGATTCCCTTTGGGTGTGCATTGTATTCTTGGAACATTACTTTGACCACCCTTTATTGAACCACTTCACAAGCTCTCTGGAGGAGTTGGTTTGAAACACTGGCTTTTCGAAACCATCAAGTCTTTCAAAGACTGTATACTTGAAGTCGTTCCACACACAATCAATTTGAACAACGAATAGGTTGTTATTGGTTTCGTTGTCTGCGATTCTGAAATCATCATAGAGTGGACCATTGAGTGGGCAGTTGTTCTTGAACCAAACATAACTTGTTTCAAGGTCTACCTTTCCACCAGCTTTGAATTGCTTGATGATGTTACCCATCTTTATTGTTTTGTTTACTAGACTTGAATCTCGACAAAACCAATCGAACCAACCTGCCTTGATTTGAGTTGTTGAATCAGGCTTATCGAACTCACCTGACTTAAATCTTTGAATCCATTCAGATAACTTGATTTGTTTATCCATCTTGTGACCTACTTTCTACCTTTTGGTATGTATATATATCACTCTAAAGACCTTTTATATCAAGTCAATTCGACACTAAATGCTTACTATAGTGATAAATTTTGAAAGTCATCAATGTCATTAAGCGATAGCTTCTTACCCTTTCGGATCAGATAGCAATTGTCACTTGATCCTTTGTGTCTTATATATCGTTTAACTATCACATCGACGAATCTCTCATCAAGTTCCATTAGATAAGATTTTCTTTGAAGCTGATCGGATGCGATCATAGTTGATCCAGAACCACCGAACAAATCGAGTACATATTCATTAACTCTGGAGGAGTTTGCAATTGCTCGTCCACAAAGTTCAAGTGGTTTCATCGTTGGATGGTCATCATTTCGCTTAGGCTTGTTATATTCCCAGATGGTATCTTGTGTGCGGTCATCAATAAAGTAATGAGCTGCACCTTCTTTCCATCCGTAAAGAATAGGTTCGTGTCTCCAGTGATAATCTTGTCTACCTAGTACTAAGGCATTCTTAACCCAGACTAAGCACTCCGCCAATTTGAATCCTGCATTCTTAAATGCATTTCTAAAGTTGATACCTTCTGTATCCGCATGACAGACATAGATGGCTCCACCAGGTTTGGTTGCTTCAAACATATTTGTGAATGCGTCATATAAAAAAAGATAGAAGCTGTTATCTTCCATCTTGTCATTCTTAATCTTGCCAGCTGTTCCTTCATAGTCCACATTATATGGTGGATCTGTGAAGATCATATCAATCTTTTGTCCATCCAGGAGTTTTTGAACATCTTGTTTCTTAGTTGAGTCACCACACATGACTCTGTGATTATCTAATAGATAGATATCACCTAATTCAGAATAGGGTGTTTCACTAACTTCATCAGAAGGATCGAAGTCATCATCACTCGCATTATCTGGGACATCTGACTCTAACTCTTCAAAACCAAATTGAAGCATATCAATATCGATATTCGAGAGTTCTTCTTCTAGTTTACTAAAATCCCAAGTAGCTAGTTCTGCTGTCTTGTTATCTGCCAAACGAAAGGCCTTAATTTGCCCTTCTGTGAGGTCATCTGCAGTAATACAAGGAATAGTGGCCAATCCTAGTTTAAGGCTTGCTTTGAGCCTAGTGTGGCCGGCAATTATTACTAGATCCTTGGTGATCACTATCGGAACCTTGAATCCGAACTCTTTGATACTATTAGCTACAGCATCGACAGCAGCATCATTATTTCTTGGGTTGTTTTCGTATATTAACAACTCCGAGGGTTTCTTCATCACTATGTTCATTAATCCAAGTTTCCTCGCCTTTTTCTATGCGTTTAAGCATGATGTCAATTTCTTCTTTACGTTCGTTGTATTCACGTCCGAACTTTATTATTAATAAGTATTTGATAGCATTAAAATCGGGTAGAGCTTTCTTCTTAGTTTTCACAAGTCGCTTCTTTGTACCCGATGATGTTTCTTCAATGATGGTTTGTACTTCCTCATACTCCATACCAACAGCTCGTTGGAACAAGGCATCCATGAGCTTATACTTAAGTTCATCATCTCCATTGATAAATGCTTGATTTAGTCTGGGATGAGATCGTTTCAATTTGATAAGTGTGTTCTCACTTAGGTTCATGGCTTTGGCGATATCCTTTTGGATAATCCGCCTTGCTACCATATCTTGAATACTTTTTATTCGTTCATCAAGTACTCCATCAGCCTCCCATTGCTGATATGTATCCAGTACCTTTGGCACATCGATTCCAACCTTTCAGGGTTCAGTAAATTTATCAAAAACTGAAGTTATCCAAGGGTTGAATACTACATATTTTTCTGCAAAAGAAAAGAAACCCCCTGTTTTTGAGAGTTTCTATCTTCTAGGCTTCATCTAAAGCCAGTATTCCACGCTAATTGTAGTATATGAAATATGTCAATTTTTGTCTACATGCCGGCGGCACAATAATCTTAGCAAAGTCGCGCTTTTTAACGTTTCTTGCCATAGTACTTGAAGCATACTTGACAACTACTTTAACCACACTTGTTATTAACTTGCCTTATAGTTGGCATTACTGTTCACAAGTATTATCGGTAGCCACAATGATTTTTACTTTTAATTCTCGATTAATTACTTTGAACGTTTTGAGTTTTTATAAAATCAGCCAACTCGATTACTTTAAGGTTGTAATCTGCGACTAGAGCAGTTACTAGATTAACCAATTCGTTTTCAGCCTCAGATGGATCATTAATTGTGTTTTTTAATGTTATCTCTTCTTCTAGATTCTTGCTTAGTAAAAGTTCAATGAATTTAGAAAAAGTTATAGATTCATCCATTTTGTATACTTCAATTATTTCTTGATTCATAATTGCAATTCCTTCGGTTACTCTAGATATTGTTATTTCCATATTCTTCTTCTCCTAAGATATTTCCATATTTTTTGTTTCTGTTCGAAAATGATGGTTTACCACCGTCTAATATCTTCATGATATTAAGTTTATCATCAACATTTTCAATAAAATAATTAGTGTATGTGATATTGCCATCATTTTCAGCATAAATATAATTAAATGCATCACCATAAACTGCTACTGATGGGTTATGTGTAACAAAAATCAGCTGTTTATCTCGTTTTTTTGACTTAATTAATGGAACGAGGTAATTACTTATATAATCATTATCAATATTATCTTCTGGTTGATCAAACATAAGAATGCTTTCAGAAAGATCAAAAATTAAATCAAGATAGGCAACGCTTTGCATGCCTAAGGATGCGTTAGATAAGTTGGTGATTGACCCCTCATCTAATAGTTTCAAAATATCATTGTAATTATTAATCTCTAAATTTGGAACCGACTTGCTGTTCATTTGATAGAACTCTTTCTTAGGTAAAAATATATCACTGTTTATGAACTTTTTCAAACCATCTGTCATATTCGATACTGTAGATTTTAGATTTTTTTCACCATTAACATATTTTTCTAGTAATGTAATAGAATTCGTATCGTTCTTTAGCTTTGATATTGAGTTTGTTAATTCTTCAACGAGCAGATCAGTAATGTTATCTGGAATTTTATATGTAGTAACAAACATATATTTATTTACAATGGCTTTACCTATTTGTGGAGCATCTAAAGTGAAATTATTCAGCAAATGTTTTAATTTATTAAACTCAAGCAAAATTGAAAAGTTATTTTTTAGACTGGTCAATATTTGATTAATCTCACGTCTTAGATCTGTCATAACTCTCTGCAGTTCAGTTTTCCCCTTATTTACTACACCAATTCTTGTGTTATGGTTGTCAAAAATGGAATTGTAGAGATCATATAATTTCTTGAAATATGCGTGATTTTTTTTCAAGACTGAGAGCTGAACACTTATACGTTCACTGTTTATTCCTGTTGAAGAAATATCGGTCTTTATTTTATTCAACATCGTTTCAGCATTAGTGAAATATCCATCAATTGTGGTGAAGTTGAGTTTATTGTGAATAGTAAAAGTGAAGAAATCCAGTCTCCTAATTTGCTTGACTATTGAAGTTATGCTCTTGTAGTTTTTATCGTATGGTTTAACCCCTAGAGCAATAGATAGTACTAGTTCCAACTTTGATTTGTCATATGGTGCAAGTATCGGAAACTTACTAGAAATTGTTTGTAATGCTCTATCTGGGTTCTCGTAAACCTCTTTAATTTTATCCTGCTTTATTATAGCTATTGATGATAACTGTCCTTCTGAAAGTGGGATTCCATCATAGTAATTACCAGAAATGTTTTTAATGTCAAATGCTTTATATTCTTTAATATCCAAACTCTCGCGATTACTTAATCTTTCAATAACAGATAGTAAAAGCGATTTACCGCTACCACGTTTCCCTACTATAACATTCAAACCAGGTGAAAATTGGATGGGATGTTGAACGCCTTTCATACTAAACTGTACGGAACCAAGTATATTACCAGGAATAACCACTTCGTTATCAGTAGTTCTTATGATTCTCGACTTAGGATCAAGAACAGCCATTTCAAACGAATCAAAATATGTATCGTAAGATCCGAAAATGAAGTTATTCAAAACTGGTGAGTAAGGTTCGGAGTTGTGCCAATCACTAAAAGTAAAATATGAGAAATATGAACCGTAGTTAACAATATACTCATACAATGCCTTCTCGTCATCTTCAAGCGTGTAGTTTACATCATGGATTCTTTTTCTGATATTATCGAGTAATGTTTTTCTATCTTGCTCTGTCTTATCATTAAGTATCTCATCAGCTCTTACTGAATGTGTATAAAAGTTTGCTGCCCATTCATTTTGGCTGATTTCATTAAAGCTCGGTCTAACATCATATGCGCTAAAAATTTTATACATCGCAAATTTGTATATATCATCTTTAGAAATATCGTCGAGATACTTTAAAACATCAACAATCCCTTTCGCTTTATTACCTTCGGGTATAAGTATAAACTTCGTTTTTAACCGAAATAATCCAGCAATTATCTCACTTAATAATGGTTTTTTCCCGTCTTTGTAAAGTTCAGTAATAATAGGGTTTATTTTTGTCATATCGACATTTGGAGAAAAATATGTTCCCATTTGAAAAAAGTTATTAGTGTCTACATAAACATCTAACTCAACCCCATAAATCAGTCTAATATTTTTATCCATTATATAATCTGTCAGTTTCGAATAAAAATCACAATCGAAAACATTATGATCAGTCACACTAAAAACTTCAACACCAGCATTAAGCAATATGTTTGCAAAAGATTGTGCATCCATTTCTTTGACTCTACCATTATCCTTGTGTTTTGAAGCAAATGAATGCATATGTAAATCATACTTAAGCCATTTCGATTTGTTCATTATATTATCCCCTCCTTGACTCGTCGTAATTATATAAAAAAAACTCTATAAGATTATTATAGAGCTAATACATGATAAATACAAAATTTATTTATATTTAACACATTCCAATATTCGTTTTTTTGAAGTAATCAAATACAAATTTTGTGATTTTGCCAGATGTTGAAAACATTCTTATGTCATTTGTATTAATGTGTTCTTGATAATCGTCTGGTTTGCAATTTCTTCCAAATATTACGGAATTCCTTACATGTTTTATCACTAATTCCCAAAATATCAATCAAAATGACACTATCAATAAGATCCATCACAACTTCAATAGCACTTCCTTTGCGAATTAAATCGTCTACTTTTTTGAGTGTCTCTAGCAATAAAGCATTATCAATATTATCGATAATAGGCAAATAAATATCTCCTACTTCACTCGGTAAAATTTCAAGTACTCCACCACCATAACTACGACCGTTAATTTCAGTGAATGTCATAGATATGCTATTATAATAAGACAGCAATACTATATTTGGATTCACTCCTTCACGAAATTTTATTCTGTGCATAGTATCAGTCGATATCGCATTGATCTTATTGATGACAAATTTAGGATATAGATTGTTTCTTCTTAAGAAAAAAGCGTCAGGAATCCAAATTGAAGGTACAACGTACCATTTATCACGTATTCTACATTTATAACCAGTATTTGCTTCGTTATTTACACCATACTCGATGTACTTTTTGTACCCATCTTTCAAAAGATTATCATTTTCGGGAAAATGAACTAAATATGATCTTCTACCTTTTTTGACATTAAATTCTGCATCACTTTTTGTATAGAAAATACCATGGACATGTGAACTTTTACCTATTAACGGTATACAAACTTCACTTAGATCGTAATTAATTTTAGTTTCATCAGTAACTGAAAAATATGAGTTGTTTCCAGTTGTGACACCTACATTGATTATCGCATAATCAGAAAATTTCTTAAAACGAGCATCTTTCTTTATGGAAGATATAGCCGAAATTTCACTGCTATCCACAAAGTATTTTGTCCATTTTTCTGAAGTATTATTTGTTTTTATAAAAGGTATAGTGTCAATATCTAGGTTATCAATATCAGAAACATTTGTCATTTGTATGACTCGGATTCCTTTATGTTTTAATCCTTTTTTTGCAATGAGAACTACAACCTCTTGCTCAATGTCCGAAAATATTAACTCTGTAAATGTGAGCAAAGTAATCTCACTGTATTTAGAGATTAACAGATCACGCAATTGTCTAGCGTATACAACTTGTAGCAACTCTGCTGGTAAGACAAAAACCATTGTACCATTATTGCTCAAAAGGGTTGTTGATGCCACTACAAAGGCAACCCATGAATTTATTAGTTTATTAGGGACTAGTCCTTCATGAATTAGCATTTCTGACATTTCATTTCTTTGTAATTCTGTTAAATATTGATATCTGATATATGGTGGATTCCCTATGATTAAATCAAATGAATTATTTATATTATCTAAGTAAAACTTAAAAAAATCTTCATGGACTATTTCTATATTAGATTTACTCCCATATTTTACAGAAAGCTTTGTGGTCTCTTCTTCGTTAATTTCAACTGCTGTAATCTTTGTACTTTTTCTCAATCCTGACTCAATTATTGCGTCTATAAAAACACCGTCACCGCAACTCGGTTCAAGTACGTTTTTATAGTCGGATAGACGTATGAATTTGTTAACTATAGAAGTAGCTAAATCATACGGTGTATAATACGCTCCTCTTAGTTTGATCTCTTCAGTATTACTCTTTAGCTTCATTTGTTCCCCTCAATAAGTTTGAATATCATTCTTATTTGATTATTTATATTTTCTATCAATGCTTGCTTTTTACTTTCAAGTATCATCGCTCTTTTACGTACCTTTTCATTTACTAAGTTAGTATTAATCTGTCTAATATGTTGAGCTGATTCTGTTATATTCCTATGAATTTCTTCCTCAAATTTATTACTTAAATCAAGCGGATATATCAATATTTGATTCAGAATTGATGTTCCTCTAGAATAGAACCCATTTTCAAAAGGACTGCCTAAGTCTCTTACTAATTCTTCTATTATTTCAGAATTTAACCATGCTTGAATATACTCCAAACTGTATGGACTACAATCTTTTACAGCTATAGCACAATAGCCTGCTGTTCCACCAGAAGCTATAAGCATATTATCTTCATCAATACAATACATTGGAGTGTCACTCAAAATTCGTACAATTATCTTTGTACGACTATTGAAAGAAGTCAATGCTTGAGTACGTCCATATTGGTACCAAGTATCGTGAGTACTATTTGGAACATCTCTAGTTCCAATTGTAGGATCTATTTGTTTTGGCACCAATAAACTATAACAATCCATCAAGTATTCCCATGTTTTTGGATACATTTCAATCATTACACTCTTTTCGATCAAATTGCCACTTAGATCATATGGAAAAATAATAAATTTGTCAGTAGACAATTTATCATATGTTGTAAAGCCTTTTTGATTACGCAAAGTAGGTTTAAAATAAGGTCTAAGGATCGATTTTTCGATATGATATGTTTTCTTATTTCGGACCACTGATATAAGGCTGTCATTCTGATCACATATTTCAGATTGAGAGAACCAATATATAGGTTTCGGTCTTTCCGCTGATGTTTGAATTCCGTTAAAAATATCAACATAATTTATGATGCTCTTCATACAATGATTATATGCTTCTTTAAATGCTACAGAGTGTAAGCTCCATGCATCATTAGCAATGTTTTCCACACTGATTTCACCAGATAGTAGCACTTTACTAAGTAGTAAATCATCAAGATTGCTAACTTTGTTATATTTAAGTGTTGAATTATCAACTTTCTTTTTTGAGGCAAAGAATAGCGATGTATATGTTGTCTTGTCCTCAAAAAGCTGTGTATCACCAAAATCAAACACTTCGATGCTCGATAACTCAGATACAAGTATTTCTCTTAACATAATACCCGAGTTTATTTTCATAAATTTGTTTGGAATTATAAAACCCAAGACACCATTGTCTCTCAACAAATGAATTGATCTTTCAACAAACAAAAAGTATTTGTCAAACTGCTTGTATGCCGCCTGATAATTTTGTTTGTAGTACTCAATTTCTATTGGACTTAATAGTTTATACATTCCCTCTGTATTGACATAGGGTGGGTTACCAACTATTACATCGAATCCAGAAAAATCATTAAACTTGGTCCAACTAAACGGAACAATTGAGAATTCATCCTGTGAGGTAATAGAATCATTATCGAACACATTAGTATTAACCAGTGAATTCCCAAATAAAATATTATTATCAAGCTTTGGTAATAGTGATGTTGATTTATCAAGTGTCGCAGATGTTTCACCTTCAAGCAGCTTAATTAACAGTGAGAATTTCGATACTTCAACTGCTTGAAGGTCTATATCTACACCATACATACAGTTAATCAATATTTTTCTTTTGTCAGCGAATGTTAATTTAGGAAAACCAGATTCAGAGAACTCAATTGAAGTCGGTTCATTTTCTTCATACCATTCAACACAGTATTCTTGCAATTGAGAATACATCTCGACTAAAAAGACCCCTGAGCCGCAGCTTATATCAGCGAAGCGAAGTTTGACAATATCTGATGGTGTTAATCCATTCACCTTTCTATCTAGTACGTTTTTCACAATAGTTCGTACTATTTCAATAGGAGTTGATATTATAGATTTATCAACATAGTCTTTTTTCTTCAATAAAACAATTTCATCGGCAATGATGGATATTTTTTCAGTAATAAATAATTCGTATATTTTGCCCAATATGCTTGGTTCAATAATATTAAAAAGATATGGGCTCTCTGGATAATATAGTTCCTTAATAATGTTATAAATTACCAAATTATTCAAATCAAACATTATTCCTTGGCCGCTAAAGATGCCTGAATTGAATCGAGCATCAGCATCTTTGAAAAGCTCATTTAGTTTATTAAGTCCTAGATCAATATCATCAAAACTGCTTTTAAGTTGATGGTATGTAGATATGTTTCGATCCTCACATATACGCAAAAAAATGAGCTTATTAATAAACCTTTGAATTTCATCATCTAGATAATCAAGGTTTGAATACATAGCATAATTTGTGTTGACTAGGTTTTTTGCAAGCGAAACACGCCAATTATTCATTTGGTTTAAAAAGTACTTATCAATTGGGAGTATCGTTCTTGATAGTTCAAAAGAACCTTCAAGAATACTATCAAATTCACCACTGTAGACGATGTCCTTTGATATAATGCCTTTAATCTCATCGTATCTTGTTATATACTCGGTGTAATGGAATATCTTGTATCTTGATTTGCTTACAGAGTCAGTATTTAACGGGGGTTGTTTTGTATCGTAAATTACCAAATATTCGAAATTCGTCAATATTGCAATTTTATGATTGGCGTTCCATCCGTACTTTCTTGTTTGCAATGCTGAATTATCGGAGTGTAATATATCCACCGAAGGTTTCTTTGCCTCAACGAATAATTTACTTATACCTCTTAATGTCAAAGTATAATCAGGTCTAGACATGTTCTCTTCATATTTTTCAACAACAACCTCTTTATACTGTGGTTTATTACCAATACTGTTATAAACATCCCAACCTAAAAACAAAAGTAACTTGTCAATATACTCAAGTCTGCAGGAAGTTTCATTAAATGCGTTTAATGGATTTTTATAGTATTCAATATTTTCACTAAATCTATCGATTATAATTTGAAAATCCTCTTTTGTTATAAGCAT

Protein sequences of DBSCAN-SWA_1

>MIDB01000008|1621:18180|3884_5195_-|OHE44686.1|DBSCAN-SWA
MVHNYICNCSICNTPIRLRFQVDHYDIPVNIHCPVCSTLISGTIRIPNDDGPLSLDQNEWFQYQIKNVHKSNDKPIYVAELSAEFFQRKLRKDDDIPDITPFLRMMMLGGEESVLNLQSLHKSYDDLLRMKNSMKNLNNLWINNKIDILIQNLEKDDPYTSILKSGDYIYAAKSRIDARLILHHARKYWLSGLINKQTFIEADKVRITVHGKTFLYPEIARFSSYLYGKNKFLDFDIKILKLTEEFIDLFPLLIPIVNNYEIIDRFDLNELGVTTVSYENLVDFYMNMYETYCDHCDLIIGINNIMHRQKYDSFSNRKGFDFDETVNSVGSKYNKVNQLVNGSEVFGHTYKSVVNNNIRNAIAHRTFNMDVINQRINFIDKNKDKERINSLYFVEFGVLCLKLFYKLNVLYEMKHQLEMFYLVVVKREKQNYGLSK
>MIDB01000008|1621:18180|5303_5885_-|OHE44687.1|DBSCAN-SWA
MQPQKKRLDFNIGPIKVKFRNEFQRIFEIKESEDSKFNVLEIGYLEYNDICVVLAVKEDTEDETVIPFIAETKKDDEYIIMFDYECYMKINDQKYRCYIAHELGHIVSEIKGKKFPLQSYEDKEQEALANIVNQNEHSADLEALGLLRNKNTYINSLNYLIDRFNEIVPNNSDEIKKKNIYIQTMKLRISALN
>MIDB01000008|1621:18180|7716_8091_-|OHE44691.1|DBSCAN-SWA
MFQEYNAHPKGIKTTDCVVRAISTAMNKDYMECRRELNQLKREWKFTSYKDTEFLYKYFEGKPRLIFKAIKGEPRIKGSTFTGLYTRGTYVLKMTGHVTVCKDGVILDTWDCTYRSVYTAWKID
>MIDB01000008|1621:18180|6200_7340_-|OHE44689.1|DBSCAN-SWA
MKIITSESVFSGHPDKICDQISDAILDAIFEQDQSARVAVETAIKDDLVVIFGEVTTTANVQYSDIAKQVLKDIGYDDTFCVLEKISKQSPDIAQGVNETLDHQQGAGDQGMMYGFACNETPELMPLPIVVAHEIAKEVDALRKAKYNHIFGPDGKCQVSVRYVDGQPFAYDTIIVSAQTRPGASLSLAKEIIIEEVLKPMISKDLTSINVLINPTGAFIIGGPYGDSGLTGRKIIVDTYGGYAKHGGGAFSGKDVSKVDRSASYYARYVAKAVVAAELADTCEVCVSYSIGVANPIAVSIDTLGTGKLSDEDLLELVKQYFNFTPGNIRKELEFETVKFQKLAAYGHMGREDLPVRWEHVEAKAAELKEAYEKAKGSA
>MIDB01000008|1621:18180|3261_3600_-|OHE44684.1|DBSCAN-SWA
MSKIKDVNIEIERLRSLFSSVDETKTQLVDNLIEQAAFMKVELGVLQEQIRKYGAVQVSSKGAQRQTEAAKYYTKLINSYGTVIKTLNSIMGKNVIDGDDAFDEFLKKANMA
>MIDB01000008|1621:18180|7407_7704_-|OHE44690.1|DBSCAN-SWA
MKTNFIRKATSTELIPNDEFVIDKQVVIDKDLFECFIKDPLNDYDFIKENLEHMYCDQEEVFHCIFVTSDSHDFGILVESEGYHYARYTAYLPKAAIK
>MIDB01000008|1621:18180|13561_15184_-|OHE44697.1|DBSCAN-SWA
MKLKSNTEEIKLRGAYYTPYDLATSIVNKFIRLSDYKNVLEPSCGDGVFIDAIIESGLRKSTKITAVEINEEETTKLSVKYGSKSNIEIVHEDFFKFYLDNINNSFDLIIGNPPYIRYQYLTELQRNEMSEMLIHEGLVPNKLINSWVAFVVASTTLLSNNGTMVFVLPAELLQVVYARQLRDLLISKYSEITLLTFTELIFSDIEQEVVVLIAKKGLKHKGIRVIQMTNVSDIDNLDIDTIPFIKTNNTSEKWTKYFVDSSEISAISSIKKDARFKKFSDYAIINVGVTTGNNSYFSVTDETKINYDLSEVCIPLIGKSSHVHGIFYTKSDAEFNVKKGRRSYLVHFPENDNLLKDGYKKYIEYGVNNEANTGYKCRIRDKWYVVPSIWIPDAFFLRRNNLYPKFVINKINAISTDTMHRIKFREGVNPNIVLLSYYNSISMTFTEINGRSYGGGVLEILPSEVGDIYLPIIDNIDNALLLETLKKVDDLIRKGSAIEVVMDLIDSVILIDILGISDKTCKEFRNIWKKLQTRRLSRTH
>MIDB01000008|1621:18180|15180_18180_-|OHE44698.1|DBSCAN-SWA
MLITKEDFQIIIDRFSENIEYYKNPLNAFNETSCRLEYIDKLLLFLGWDVYNSIGNKPQYKEVVVEKYEENMSRPDYTLTLRGISKLFVEAKKPSVDILHSDNSALQTRKYGWNANHKIAILTNFEYLVIYDTKQPPLNTDSVSKSRYKIFHYTEYITRYDEIKGIISKDIVYSGEFDSILEGSFELSRTILPIDKYFLNQMNNWRVSLAKNLVNTNYAMYSNLDYLDDEIQRFINKLIFLRICEDRNISTYHQLKSSFDDIDLGLNKLNELFKDADARFNSGIFSGQGIMFDLNNLVIYNIIKELYYPESPYLFNIIEPSILGKIYELFITEKISIIADEIVLLKKKDYVDKSIISTPIEIVRTIVKNVLDRKVNGLTPSDIVKLRFADISCGSGVFLVEMYSQLQEYCVEWYEENEPTSIEFSESGFPKLTFADKRKILINCMYGVDIDLQAVEVSKFSLLIKLLEGETSATLDKSTSLLPKLDNNILFGNSLVNTNVFDNDSITSQDEFSIVPFSWTKFNDFSGFDVIVGNPPYVNTEGMYKLLSPIEIEYYKQNYQAAYKQFDKYFLFVERSIHLLRDNGVLGFIIPNKFMKINSGIMLREILVSELSSIEVFDFGDTQLFEDKTTYTSLFFASKKKVDNSTLKYNKVSNLDDLLLSKVLLSGEISVENIANDAWSLHSVAFKEAYNHCMKSIINYVDIFNGIQTSAERPKPIYWFSQSEICDQNDSLISVVRNKKTYHIEKSILRPYFKPTLRNQKGFTTYDKLSTDKFIIFPYDLSGNLIEKSVMIEMYPKTWEYLMDCYSLLVPKQIDPTIGTRDVPNSTHDTWYQYGRTQALTSFNSRTKIIVRILSDTPMYCIDEDNMLIASGGTAGYCAIAVKDCSPYSLEYIQAWLNSEIIEELVRDLGSPFENGFYSRGTSILNQILIYPLDLSNKFEEEIHRNITESAQHIRQINTNLVNEKVRKRAMILESKKQALIENINNQIRMIFKLIEGNK
>MIDB01000008|1621:18180|9755_10274_-|OHE44694.1|DBSCAN-SWA
MPKVLDTYQQWEADGVLDERIKSIQDMVARRIIQKDIAKAMNLSENTLIKLKRSHPRLNQAFINGDDELKYKLMDALFQRAVGMEYEEVQTIIEETSSGTKKRLVKTKKKALPDFNAIKYLLIIKFGREYNERKEEIDIMLKRIEKGEETWINEHSDEETLGVVNIRKQPKK
>MIDB01000008|1621:18180|3613_3805_-|OHE44685.1|DBSCAN-SWA
MYKIGDKIRIINMKGEDHYNGREGVIEYIDGLDQLHGTWGGLAIIPEEDLIEVINSEVVERVN
>MIDB01000008|1621:18180|1621_3265_-|OHE44683.1|DBSCAN-SWA
MNYLIEYYQKVMSNEILAGEELKSTLRKLMDDMVNPRYDFDEKPGNMRIDFIETFCKHTKSPFNGQPFILELWEKAIIQTAYGFKIAESGLRRFNEVILLIARKNGKTTFIAGIDLAEFFLSKGGVDIVCASNTSEQANILFEEINNMREQSPTLSNEKRSKKNIFFIYSPKTKNKIKKLSAQSRNKDGYNIEVGCIDEVHEMTDSKVYDAIKQSQSTKKEPLIFIITTEGTTVGGFLDNKLDYARKMLKGEITDERVLPWLYTQDNTQEIYDDPKNWVKSNPSLGVVKLSSYLEDVMNKSKNDHSTRVTMLCKDFNIKQVDQGAWLSFDDLNNEAKYELSTLKNSYAIAGVDLSSTTDLTAAILIIQKKDDNKKYVLSHFFMPSDVVKKRMEEDNVPYDIWIRRGFITLTEGSQNDFSLVTQWFMKMIQEHQIRPLWVGFDPWNSQYWIKEMEELGFNMEKVRQGVYSLSEPMKQLEADLKNKLINYDNNPILKWCLSNTQAKVDLNGNIQPSKLNSKYKRIDGTVALIIAYAVLNRYKIDYENML
>MIDB01000008|1621:18180|10639_10921_-|OHE44695.1|DBSCAN-SWA
MEITISRVTEGIAIMNQEIIEVYKMDESITFSKFIELLLSKNLEEEITLKNTINDPSEAENELVNLVTALVADYNLKVIELADFIKTQNVQSN
>MIDB01000008|1621:18180|8090_8519_-|OHE44692.1|DBSCAN-SWA
MDKQIKLSEWIQRFKSGEFDKPDSTTQIKAGWFDWFCRDSSLVNKTIKMGNIIKQFKAGGKVDLETSYVWFKNNCPLNGPLYDDFRIADNETNNNLFVVQIDCVWNDFKYTVFERLDGFEKPVFQTNSSRELVKWFNKGWSK
>MIDB01000008|1621:18180|8605_9817_-|OHE44693.1|DBSCAN-SWA
MNIVMKKPSELLIYENNPRNNDAAVDAVANSIKEFGFKVPIVITKDLVIIAGHTRLKASLKLGLATIPCITADDLTEGQIKAFRLADNKTAELATWDFSKLEEELSNIDIDMLQFGFEELESDVPDNASDDDFDPSDEVSETPYSELGDIYLLDNHRVMCGDSTKKQDVQKLLDGQKIDMIFTDPPYNVDYEGTAGKIKNDKMEDNSFYLFLYDAFTNMFEATKPGGAIYVCHADTEGINFRNAFKNAGFKLAECLVWVKNALVLGRQDYHWRHEPILYGWKEGAAHYFIDDRTQDTIWEYNKPKRNDDHPTMKPLELCGRAIANSSRVNEYVLDLFGGSGSTMIASDQLQRKSYLMELDERFVDVIVKRYIRHKGSSDNCYLIRKGKKLSLNDIDDFQNLSL
>MIDB01000008|1621:18180|5929_6226_-|OHE44688.1|DBSCAN-SWA
MKKPKVLHNFYKSPAWLAAREIKIMSVNGLCERCGQIGIEVHHKERLTIENVNDSSISFNQENLELLCRECHNKEHDRFNNKIRFDVDGNLINPEKPN
>MIDB01000008|1621:18180|10901_13373_-|OHE44696.1|DBSCAN-SWA
MNKSKWLKYDLHMHSFASKHKDNGRVKEMDAQSFANILLNAGVEVFSVTDHNVFDCDFYSKLTDYIMDKNIRLIYGVELDVYVDTNNFFQMGTYFSPNVDMTKINPIITELYKDGKKPLLSEIIAGLFRLKTKFILIPEGNKAKGIVDVLKYLDDISKDDIYKFAMYKIFSAYDVRPSFNEISQNEWAANFYTHSVRADEILNDKTEQDRKTLLDNIRKRIHDVNYTLEDDEKALYEYIVNYGSYFSYFTFSDWHNSEPYSPVLNNFIFGSYDTYFDSFEMAVLDPKSRIIRTTDNEVVIPGNILGSVQFSMKGVQHPIQFSPGLNVIVGKRGSGKSLLLSVIERLSNRESLDIKEYKAFDIKNISGNYYDGIPLSEGQLSSIAIIKQDKIKEVYENPDRALQTISSKFPILAPYDKSKLELVLSIALGVKPYDKNYKSITSIVKQIRRLDFFTFTIHNKLNFTTIDGYFTNAETMLNKIKTDISSTGINSERISVQLSVLKKNHAYFKKLYDLYNSIFDNHNTRIGVVNKGKTELQRVMTDLRREINQILTSLKNNFSILLEFNKLKHLLNNFTLDAPQIGKAIVNKYMFVTTYKIPDNITDLLVEELTNSISKLKNDTNSITLLEKYVNGEKNLKSTVSNMTDGLKKFINSDIFLPKKEFYQMNSKSVPNLEINNYNDILKLLDEGSITNLSNASLGMQSVAYLDLIFDLSESILMFDQPEDNIDNDYISNYLVPLIKSKKRDKQLIFVTHNPSVAVYGDAFNYIYAENDGNITYTNYFIENVDDKLNIMKILDGGKPSFSNRNKKYGNILGEEEYGNNNI

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
OHE44683.1|1621_3265_-	hypothetical protein	A0A290GJW3	Caldibacillus_phage	4.1e-110	39.0
OHE44684.1|3261_3600_-	hypothetical protein	A0A290GJQ7	Caldibacillus_phage	1.0e-07	30.9
OHE44685.1|3613_3805_-	hypothetical protein	NA	NA	NA	NA
OHE44686.1|3884_5195_-	hypothetical protein	NA	NA	NA	NA
OHE44687.1|5303_5885_-	hypothetical protein	NA	NA	NA	NA
OHE44688.1|5929_6226_-	hypothetical protein	R9TNN2	Paenibacillus_phage	2.2e-14	44.9
OHE44689.1|6200_7340_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	6.9e-88	45.5
OHE44690.1|7407_7704_-	hypothetical protein	NA	NA	NA	NA
OHE44691.1|7716_8091_-	hypothetical protein	W8EK91	Geobacillus_phage	9.3e-10	31.4
OHE44692.1|8090_8519_-	hypothetical protein	NA	NA	NA	NA
OHE44693.1|8605_9817_-	lactate dehydrogenase	Q708N6	Streptococcus_phage	4.7e-103	49.4
OHE44694.1|9755_10274_-	hypothetical protein	A0A2K9V3J2	Faecalibacterium_phage	3.0e-06	32.7
OHE44695.1|10639_10921_-	hypothetical protein	NA	NA	NA	NA
OHE44696.1|10901_13373_-	hypothetical protein	A0A1B1IUG5	uncultured_Mediterranean_phage	6.2e-09	36.9
OHE44697.1|13561_15184_-	DNA methyltransferase	A0A2I6UHU5	Bacillus_phage	4.3e-19	27.8
OHE44698.1|15180_18180_-	hypothetical protein	A0A2R2ZGH5	Clostridioides_phage	2.3e-26	26.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
MIDB01000008.1|OHE44692.1|8090_8519_-|hypothetical-protein	8090_8519_-	142 aa aa	AcrIIA11	NA	NA	1621-18180	NA

Protein sequences of MIDB01000008.1|OHE44692.1|8090_8519_-|hypothetical-protein

>MIDB01000008.1|OHE44692.1|8090_8519_-|hypothetical-protein
MDKQIKLSEWIQRFKSGEFDKPDSTTQIKAGWFDWFCRDSSLVNKTIKMGNIIKQFKAGGKVDLETSYVWFKNNCPLNGPLYDDFRIADNETNNNLFVVQIDCVWNDFKYTVFERLDGFEKPVFQTNSSRELVKWFNKGWSK

anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome) information

• hit_Aca_id: anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome)
• identity: 0.65
• query_coverage: 0.9929577464788732
• hit_coverage: 0.9655172413793104

5. MIDB01000019

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
MIDB01000019.1|OHE42839.1|112813_113245_+|hypothetical-protein	112813_113245_+	143 aa aa	AcrIIA11	HTH_3	NA	No	NA

Protein sequences of MIDB01000019.1|OHE42839.1|112813_113245_+|hypothetical-protein

>MIDB01000019.1|OHE42839.1|112813_113245_+|hypothetical-protein
MCKEISMKDWVERFNDGIHASSDVQTQIEAGWYDWFCKDSSLANKTRRMGNIIKQIKPGGKVDLDSSFVWFKNNCPLDAPLYDDFRIADINSDSTLLVIQIDNRANECRYTVFDRLNDFKTQVFGSNSKKEFIQWINKLNRNK

anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome) information

• hit_Aca_id: anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome)
• identity: 0.6159420289855072
• query_coverage: 0.972027972027972
• hit_coverage: 0.9517241379310345

HTH_3 HTH domain information

• Identity: NA
• Hit_domain_coverage: NA

6. MIDB01000004

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
MIDB01000004.1|OHE45191.1|10567_10996_-|hypothetical-protein	10567_10996_-	142 aa aa	AcrIIA11	NA	NA	No	NA

Protein sequences of MIDB01000004.1|OHE45191.1|10567_10996_-|hypothetical-protein

>MIDB01000004.1|OHE45191.1|10567_10996_-|hypothetical-protein
MEKQITLSHWIQNFNQGEFDKKDTQTQIKAGWFDWFCKDSSLANKTKKMGNIIKQIKAGGKVDLETCYVWFKNNCPLNGPLYDDFRIADIETNNNLIVVQIDCIWNDFKYTAYERLDGFEKPVFESNSSRELVKWLNQGWIK

anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome) information

• hit_Aca_id: anti_CRISPR1288|OHE43765.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-RIFOXYA2_FULL_36_32-(subsurface-metagenome)
• identity: 0.6785714285714286
• query_coverage: 0.9929577464788732
• hit_coverage: 0.9655172413793104

7. MIDB01000007

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	113092 : 126456	16	Caldibacillus_phage(25.0%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>MIDB01000007|113092:126456|DBSCAN-SWA
GATGACTATGAATCACGAATATAACGAATTGGATTTATCTCAAAAACCAGCACTGGAGGTTTTAGAGAGTCTGGGCTACATAATTCTAAAGACTGATGAAGCTGAGTTAATGAGAAGTAGTAGATATTCTGTCATCCTCGAGGATGTTTTGAAGGTACAGCTTCAGAAAATCAACGAATTCGAGTATAGAGGAAAATTTAATAGGTTTTCTGAAAAAAACATTGAACAAGCATTACTTGATATTGATGAACCATTAGCAGATGGATTGATTAAAACAAATGAAAAAATTTATAATACCTTGCTATTAGGTAGAAGCTATCCTGAAGTTGTATCAATTGAAGATGGAGCAAGATCTTTTAATCTCAATTTTATTGATTGGCTGCATCCTGAAAACAACATATTTCATGCAGTAGAAGAGTATAGTGTTGAACGAGAGGATGGTCAAAGTAGTGTTCGTCCTGATGTTGTTCTTTTTATTAATGGTATTCCTTTTGCTGTAATTGAATTCAAAAAAGCTGATATTCCTATAGCACAAGCCATTAGCCAAATGATTAGAAATCAAGGTCAAGGCTATGTTCCGCAGCTCTTTAAATTTATTCAAATTGTCATGTCAGCTAATAAGAACTTAGTGCAGTACGCTACAACTGGTACTCCTGCAAAATTCTGGCAAGTATGGAAAGAAGATTCAAGCTCAGAGGAGTATGATTGGTATGAAGATGAACTAAAAAAGGCTGTCAAAAATAGAATTTCAACAATTCAAGATCAAAATATTGTATCTCTTTTTCACCCTGACCGTGTACTAGACTTCATAAGATATTTTATTATCTTTGATAAATATGACAAGAAAATCGCTAGATATCAGCAATATTTTGCTATAAAAGAAATAGCAAAGACTATTCAAGAGACAGATAGTGAAGGTAATCGTCAATCTGGTGTTATTTGGCACACACAAGGATCAGGTAAATCACTAACTATGGTCATGCTTACAAAATATTTAATCTCTGAATTTGCTCATTTAGATCCTCAAATAGTAATTGTTACAGATAGAATTGAGCTTGATTCACAGATACACAAGACTTTTAATCATTCACGTTTAAAGGCAGCAAAAGCAACTAGTGGCAAGAATTTAGTCGATCTAATTAGAAAACAAAGTGTAAATATTATTACATCATTGGTCCATAAGTTTGATATTGCATCTAAAAATCATACGATTGTAAAGAGTAAAAATGTTTTTGTCTTAGTTGATGAGTCTCATAGAACTCAATACGGTGAATTACATACTAAAATGATGCAAGTATTTCCCAATGCATGTTATTTAGGGTTTACTGGTACTCCACTGATGAAAGACGAAAAAAGTACCATGAAAAAGTTTGGAAGTAGACTGATTCACAAATACACGATTAAAGATGGTGTCGATGATAAGACTATTGTTCCATTGCTTTATGAAGGACGTATGGTTGAACAAACTATTAATAGAATAGCTATCGATAATCGACTAGACATCATTACTAGAAATCTTAATGAAAAGCAATCTGAAATGTTAAAGAAAAAGTGGAGTCATTTTGAGAAAATCGCTTCATCTGAACAAAGAATTAGATTGATTGCTGATGACATCTATATTCATTTCACGCAATTTTATAAGGGAACTCCTTATAAAGCAATCCTAGCAACAGATAGAAAGTTTGATGCAGTTCGCTATAAAGATGCATTTGATGAATATGGCGATATTAAAACAAAGGTAGTTATTTCATCTCCAGACATGCGCGAAGGAAATGATGAAGTTGATGGTGAACCTGATGACAGAGTTATTAAGTTTTGGAAAAAAGAAGTTGAACCTTATGGGGACCCTCTTAAATATGAGGAATATGTTAAAAACGAATTCATTGAAGGTGATGAAGTTGATATTCTAATTGTTGTTGAGAAGCTACTAACTGGATTTGATGCACCAAGAGCATCTGTTTTGTATGTAGATAAGCAATTAAAAGAGCATAGTTTGTTGCAAGCAATAGCTCGTGTTAATAGAATCTATGAGGGTAAGGATTTTGGACTTATAGTCGATTATAGGGGATTGCTTAGACCTCTCGATGAAGCGATGCAAATGTATTCAGGAGCTGGACTCGAAAAATATGATGGAAAAGATATTGAAGGTGCACTTGTTGATGTAGTGTCAATAGCCGCAAAATTAAGAGGAGCTTATTCATATCTTGTAAGTGTATTTAAAGAGGTCAAAAATAAGAATGATAGAGAAGAGTTTGAACTCATTCTTGCTGATGATAATTTAAGAGAAGAGTTTTACGATAATCTCACACAATTCGGTAAATATTTAGGAGTAGCCTTAGAATCAGTGCATTTATATAATGCATTAGGAGAAAAAGAAATTGGTCAATACAAAAAAGACTTGAAATATTATCAAGAACTTAGGGCTACAGTGAAAATACGTTATTCTGATGCAATTGATCACAAAGAATACGAACCAAAGATGCGAAATCTTATGGATACCTATATTGCTGCTGAAGAAGTTATTCGTATATCAGCACCTGTAGATATTCTTAATGAACATGATTTTGAAGAAGAACTCAATAAACTAGGGACTACTCGAGCTAAAGCTGATGCAATTAGGACAAGAATGACACAAAGAATTCACCAAAAGTATGATGAGAATCCTACGTATTACAAAAAATTCTCAGAACGCATTCAAGCTATTCTTGATGAATACAAAGAACGACGTATTTCTGACGCAGATTACTTAAAACATATGGAGACACTTAAAAATGATTTTAGAAGAGGTTATAGTGGTACTCAGTACCCTAAAAAAATAAAACACAATAATCACGCACAGGCTTTTTTTGGTGTGATAAAAGAGGCGTTTTCAACTGAATCATTTAGCAAAGGAATGAGTGATGACGATGATTATAAAGATCTACTAGCTGATATGGCCATTGAGATTGATTTAATCATTACTCGTAATAGCAAGGTTGACTGGCATGATAATCCGGATGTTCACAAAAAAATATCTGCAGAGATTGATGAATACCTGTATAATATCAAGAAAAACTCACTTCATGAACTAACTTTTACTAAGATAGACCAAATTATTAAAGACATTAAAACTGTTGCTCTAAGAAGATACTAGGTGATGAATATGTCAATATACTCTATTGAAATAGATAAAGGGAAAGTAATTCAAGTTGAATTAGTAAGAAAGAACGTAAAAAATATAAATCTTACTATCAGACCTGACTTAACGATTTTTGTATCAGCAAAACCAACTCTGCCAATGGAATCAATTGAGGAATATATAAAATCTAAGTCTTCATGGATTGTAAAAAGGATTGGACGATTCAAAGCTACTAAGTCAGTGAATACAATTAGTCATGAATATGTCAGTGGTGAGTCGTATAAGTTTCTGGGAAAACAATATAGATTAGACCTAGAATTGACGGCATCATCAGAAAGAGTTATGTTAACCGATGGGTATATCAAACTATTTGTAAAAAATAAAAACAAGAAAACAACAAAGTCTAGACTGATGGACGAATGGTATAGGAAACAGGCTAAAACAATATTTGAAGACTCACTAGATAGAATTTATACAATAATTGAACCCTATATCAATAAAAAACCAACAATGGATTTCAAGGTAATGAAAAAAAGATGGGGGTCATGTTTGAGAAGTAAAAATATGATACTTCTTAACCTGGAACTTATAAAAGCTCCAATGTATTGCATTGATTACGTGGTACTTCACGAGCTAGTTCATTTTATTCACAGAAACCATGATGCGAAGTTTTATGAGATGTTAACAGTATTAATGCCAGATTGGAAGCAAAGAAAAGAGATTTTAGATGAAGAAATAGTCTTATTTATATAGGAGGAAGTAAAGTGGCGAATACAAAAAAAGATTTAGTGGCTGGAGCACAAGATTTAATTCAGGATATTTTTGATCTTTATGATGATTATAGCGCAGAAGATCAAAAAAAGATTGAAAACATGCTATGTGATATGAAGGATTTAAACACTCATTTAAAAGGGTATGAGAAAGAAGAGAAAAAAAAGCCTAAATGGTTGTTAAAATTGGAGAAAGCATTTAATGATTACTTCGGAAAAAAAGACTAAGAAAAACGAAATTGTCGTTTCTATAGTTTCAGGTTTATTAACTATTGTCTATGGGGTAATATTTTCACTGATTACTCATTTCAACTCTGAAACTTCTCATCTAGTGATAAAACTTGCTGTATGGATTGTTGGAATCTATTTTTGCATCATCTTAGTAATTGGAATTTTAAGAATATTTAAAATCAAATTCAATGCATTAAATTACAAGTTTATTTTTATCTTAACTAGTCTGATATCTGCAACACTAGCTGTTATTATAGCGGGTACTTTTGAATTAGAGTATTTTGTTACTTTAATAGCTATTGTTGGGCTTTACGAGCTATTCAAAAAGATCATAAAAATAAATAATAAGCATGGGGAGTGATTATTATTTGGTATAAGTATATTTACGAATTTCTATTTCAAACAGAACCATTATTTAATGACTTTTTTTTAGATTGGATATTTCCAGCTGCAATTGTATTCTTACTTTATGACTTTGCGTTTGGTGTTGTAGGCGGATTATATAGAGCAGGAATAATTAGAGGTAGAGATCTAGGCAGCATAATTCATTGGGGAATCCGTTATGGCATGATGTGGGGAACAATACAGATTCTCATTTTTATAAGAGATAACTGGTTATATATTGTTTTGGCTGCAGTAGGTGCAATTATAGTTTTTGTGCTGATCGGACTATTTATTCGAAGTTTACTGATGAATAAATTTATATGAAAGGAGACAACCAAAATGGCAAAAAATCCTCCTATTGGAGATAATGCACGTGTAGGTGCTGTAAAAGACAGAAGTCAAACCAGACACTCAAATGGTGAAAATTGGGTTAAAAGAGACACAACAACTGGTCAATTTACGGGTGTTAAAATCTCATCTACAAAACCATACAAAGGTGTTCGCAAAGAAAAATAGTTTTTTATCACCGATAATCTGTGTTTACGGTTAATCGAATGAGTAAACAAATGAAATGAATATTTAAAAAATGAAACGCACGTTATTTGTGTGAAAGCAATATTAAAAGGCACTCAATTTATTATGCTATGGGCATATAGCCAAAAATTGACAATTTTGATATACTCTAAATAACGTGGAATACTGGCTAAAAATCCAGCCTAGAAGTTCAAAGGAATTCGAAAATGAGTTCCTTTTTATTTTTGCAGAAAAACTTGTAGTGTTCTAACTGGTTAACAATTACAATTTTAGTTAGTTTTGATTGTACGGTTAGGGTGATTAGATGAAAGGAAGAATGCTCGACTTATACGAGCGATGGGAACAGTCAGGCCATTTAGAAAGCAGACTTAAATCGATATCAGAGATGATATCTAAAAGAGCAACTCAAAAACAAATTGCTTTATATCTTGGTGTTACTGATAAAACACTGATTAAATTAAGAAAAGTACATCCAAGATTGGATAAGGCTTTTCAATATGGTGATGAAGAATTAAAACAAAACTTAATTGATGCGATGCTTCAAAGAGCGATTGGTTTCGAATATGAAGAAACACAAACCGTTATCGAAGAAACAAAGACAGGTACAAAAAAGCGGATCACAAAATATAAAAAGCGATCCTTGCCTGAGATTGCAGCGATTAAGTATTTACTCATTGTTAAATTTGGTCTTGAATACAACGATAAAAAAGAAGAAATAGAATTGATGAATAAACGTCTAGAAAAAGGTGAGGAGGCTTGGTCTAATGAATTTAGTCATGAAGAAAGTAACCCAATTATTAGAATACGAAAACAATCCGAGAAATAACGAGGTTGCTATTGAAGCAGTGGCCAACAGTATCAAAGCATTTGGCTTTAAGGTGCCGATTGTTATCACTTCCGAACATGTAATCATTGCTGGCCATACAAGGCTTAAAGCGGCTAAAATGCTTGAATTAGAAAGTGTACCTTGTATCATTGCTGATGACTTAACTGAAGATCAAATCAAAGCATTTCGTTTAGCTGATAATAAAACAGCTGAACTTGCAACTTGGGATTTCTCAAAGTTAGAAGAAGAGCTTTTCAACATTGATATGGATATGCTTCAATTTGGGTTTGAAGAGTTAGAATCACTTGTGCCTGATAATGCAACAGATGATGATTTTGATATCAGCGATGAAATACCAGAGACTCCGTTTTCTGAACTGGGCGACATCTATGAGCTTGGTGGTCACAGATTAATGTGTGGCGATTCAACTTCTAGCAATGATGTAAAAAAACTAGTTGATGATGTTAAGGTTGATATGATATTTACTGATCCTCCATATAACGTTGATTATGAAGGTACTGCTGGAAAGATTAAGAATGACAAGATGGAAGATAATAACTTCTATCTTTTTTTATATGATGCATTCAATAATATGTTTGAAAACATCAAACCAGGTGGTGCAATCTATGTCTGTCATGCAGATACTGAAGGACTAAACTTTAGAAACGCCTATAAGAATGCTGGATTTAAACTTGCTGAATGTTTAATCTGGGTTAAGAATGCATTGGTCCTTGGAAGACAAGATTATCACTGGCGACATGAACCCATTCTTTATGGATGGAAAGAAGGCGCTGCTCATTACTTTGTAGATGATCGTTCGCAAGATACGATTTGGGAATATAACAAACCAAGAAAGAATGAAGAGCATCCAACCATGAAACCACTAGAACTAGTTGGAAAAGCAATCGCTAACTCATCTAGACGTCATGAAACAATTCTGGATTTATTTGGTGGTTCAGGATCCACAATGATTGCAGCTGATCAACTTGATCGCAAGTCATGTCTCATGGAACTTGATGAAAGATTTGTTGATGTCATTGTCAAAAGATATATTAAACATAAAACATCAATTGATGATTGTTATTTGATTAGAAATGGAAAGAAGTCTCCATTAAGCGCTTTTGAGGTTTTTAACAATATCTCACTATAGTAAAAAAACACTTGCTATGATAAGCCTTTAGAGTGATATATATAGTAACCCAATAATTAAAAGGAGACTATAAACATGAGTAAAGAACTTAGTTTAAGAACATGGATTGAGAAATTCAATCAGGGTGATTTTGATTCGAAGGATTTAGAAACACAAATAAAAGCTGGCTGGTACGATTGGTTTTGCAAAGATGATAGTTTAGGGAATAAAACAAAACGTATGGGAAGCATCGTCAAACAATTTAAAGACTGTGGGAAACTTAATCTTGATAACATGTATGTTTGGTTCAAGAATAACTGTCCACTTGCAGGTCCATTGTATGATGATTTTAGAATTGCAGATATTGAATCAGGTGATACACTCTTTACGATTCAAATCAATTGTTTTAGAGAAGAAAACCGTTATACAGTCTATGGCAAGAGAAACGATTTTGATACACCACTCTTTGGTACAGAATCAATCAAAGAGCTAGTGGCTTGGATGAATGAAGGGTGGGCTGACAATGTTTAAAGAATACAATGCTCACCCTAAAGGAATTAAAACAACAGATTGTGTTGTAAGGGCTATTTCAACAGCAACAACTATAGATTATCTCGAAGTTAGAAGAGAACTTAACAAAAAGAAAAAAGAACTCGGATATTCGAGTTATAAAGATACCCAGTTCTTATATGACTACTTGAAAGACTATCCAAGACTGATATTTAAACCTGTAAAAGGTGAGCCTAGAATCAAAGGTACTGATTTTACAGAACTACATCCAATTGGTACATACATTTTAAAAATGGCTGGACACATTACAGCATGTATTGATGGAATCATCTATGATACATGGGATTGTAGTTATCGTTCAGTCTATACAGCATGGGAGATTAGAAGATGAAAACTAGATTTATAAGAAAGCCTGAAAGACAAGATCTGATACCTCAAGATGAGTTCATTATAGAAAAAGTGATTGTCCTAGATAAAAAGGACTTTGATAAGTTTTTAAATCATCCGCTTGATGACTATGATTTTATTAAAGAAAACGTTGAGTTGATGTATTGTGATAAAGAAAATGTTTATCATTGTATTCTTGTTACATCGAATGAAGATGATTTTGGCATATTGATTGAAAGTGAAGGATATCATTATGCAAGGTATGCAGCATATATTTCAAAAGCAGAACTTAGGAGCGAATAGCTCCTTTTTTAGTGCTTAAAGAGGAGGATTTGAAAATGCAAAGAATTACAAGTGAGTCAGTCTTTAGTGGACATCCTGATAAAGTTTGTGATCAAATTAGTGATGGCATCTTAGATGCAATACTAGAACAAGATAAAGATGCAAGAGTTGCAGTAGAAACTGCGATTAAAGATAACTTCGTATTTATCTTTGGTGAGGTCACAACAACAGCATTAGTGAATTATAAAGCAGTAGCAAAAACAGTGTTAAAAGATATCGGTTATGATGAAGAGTTTGTTGTCATGGAACTCATTAGCAGACAATCACCTGATATTGCATTGGGTGTCAATGAATCATCAAGTAAAGAACAAGGTGCAGGTGATCAAGGGATCATGTTTGGTTATGCGTGTAACGAAACAGAAGAGTTCATGCCACTTCCAATTATCCTTGCACATAGAATCGCTAAAGGTATGGATAAAGCTAGAAAAGAAAAGTATAGTCATATCTTTGGTCCTGATGGCAAATGCCAAGTGAGTGTGGATTACAAAGATGGTAAACCATATAATATACCAGTCATTGTCGTATCAGCACAAACAAAACAAGGCGTTACAAGAGCATTCTATGAAGATATCATTAAAGCGATTATCTTTAACTCTATGGAACAAGAAGACCTCATTAAAAATACACGACTTTTAATTAATCCTACAGGTGAATTCATTATTGGTGGACCTAAAGCAGACTCTGGGTTAACGGGTAGAAAAATCATTGTTGATACTTATGGCGGTTATGCTAGACATGGTGGTGGTGCCTTCTCAGGAAAGGACGTAAGCAAGGTTGATCGCAGTGCGGCTTACTATTCAAGATTTGTAGCAAAAGCCGTTGTAGCGGCAAATTTAGCGACACATTGCGAAGTGTGCTTGAGCTATGCGATTGGTGTTGCAGAGCCAACAAGTATCTTAATTAATACCTTTGATACAGGTGTCACCGATGATAGTGAAATTCAAAGTCTAGTTGAACATGTATTCAACTTCAAACCAGGATCAATGAAAAAAGAACTTGACCTATCAAATATAAAATTTAAAGAATTGGCAAAGTATGGACATTTTGGTAGAGTTGATTTACCAGTGAAATGGGAACATGTAAAAGATAAAGCTGATCAGTTGAAACGTCTTTATGAAGAAACCTAAGATACTGCATAACTTCTATAAATCTGCTGCATGGCAAGTAGCAAGACAAATCAAGTACCAGGAACAAGATGGAAGATGTGAACGCTGCAAGCGAGTAGGTGAAGAAGTACATCATAAAATAAGACTGACTATCCAAAATGTATCAGACACATCGGTAAGTTTGAATCAAGAAAACTTAGAGCTTCTTTGTAAGGAATGTCACAATAAAGAACATAAGCGATTCTCTATAGAAAAAGAATTTGATGACGAAGGGAACTTAATTCCTAGATAACCTCGATTAACTCAAATAAATTTGATATAATTGATACAATTGGGGGTGACTATTTTGAGTGATAAAAAAAGGAATAGTCTCATTGACGAGTTTTTTCAGAAGAGAAAAGTATATGAAAATATTAAAGAGTATAATGATATCCTCGATAATCTTGAGTATTATAGCGTTTTTTTGGATAACCTAGGCAAAAATAGTTATGAACCATATATATCAGTCTCAATTTTTAATGATTATGTTCCTAATTATGACTTTAACAGTGGGAATCCATTAGCACCAATATTGGAATTTTTAAAGACCATAAAAAAGGCACATGTTATAAATCTTGCTAGTATATTCGATAGTTTGAGATCTACTCTCTATTCAATACATAGAACTATGGAAGTTATAAACATTTCTGACTCATTTGCCTTGCTGAGAAAGTTCAAAGATGATTACCTATTGGCAATCTTCTTTTCTCTTCTTGGAAATTCAAACCATGAAAATAGTGGAGTATCATTTGAAAAATGGAATGAAAAAATAGATACTGTATTCAAATTTGCACAAAATTCTATGAACGATTTAAAGTCAGTAGAAGCTGTATCATTTATTACTAGCAATCCTGATATTAAAGAATTAGATAAGTTAATCGGAATTAAGTCCAAGTTCAAGGAAATGACAGATTTAATGAATAAGTACATGCATAGCCATGGTTTGTTATTCTTAAATAACACTAATCCTAAAAGACACCTCGATAGCACTATTGATATGATAAAAGTGTTCAATAAGTATCTTGATACTATAATGACTTATTTAACATGTATCATTATATATCTAAATCCAAGATTAATAGTTCCACATGAATATTTTAGAAATATGGATACTAATGATTCTCTGAGTGAAAAAACTCATCGATGCACTGCTACTTATCTTAAAGAGTTCATTGATGATCGTGTACAAGTAGTAGAACCAAAACTGTACGATTTCTTAATGAAAAAATTTTATTTTTGATTCAATTTATCCCCCGGGGTAACATAAGTTACATAGGTGCGGGTACCGCGTAGGGGGACGTTTAATTTGTGGAAGAGCTATTTATTGAAAATATAGAAATGAGGATGATTAAATGATTACTACATCTACAATTGCAAGGGTATTACAGATTGAGTTCAATGGTTCATTAGCCTCATCTTTTACCGTAGAGTCTAATAATATTCAATATTTAGTAAGTGCTAAACATTTATTTAAGAATATTGATTATGGAGATACTATAGACTTGATTGTTAGCGCTGAAGGAACCAAAAAACTCCTAAATTGTAGCGTTTATTTCCATAAAGAAGAAAATATTGATATAGTAGTTCTAAAGTTAAATAAAAATAAAAATATCACACAAGTATTCTCAACAAAATTCAGTAGTAATAATGTTATTCTTGGACACGATGCATACATATTAGGATTTCCATTTGGGATGCTAAATTCTGATATAAAAGATAGTAAATATCCCGCTCCTTTTGTAAAAAGAGGATGTATTTCGGGTATAGTCAAAGAAAAAAACGCTAATGTAATATATGCTGACACCGTCAATAATATAGGATTTTCTGGTGGTCCAATGACCACTTACGAACCAACAAATTTCAAGGATGCATATATAATTGGAGTTATTAGTGGATATAGAATACACACATCTATGGTACATGATGAAAATGGAAAAGAAACTAAAAACTATGTTAGAGAGAATAGTGGTTTGACAAAAGCTTACTCAATAGAGCATGTGTTTGAGATTATTAATGAATTATAGTATGATGATTGAAATTGAATATAAGCGACTTCGGTCGCTTTTTTCATCGGTTGATGAAACTAAAAAAGAATTGGTTGATAACTTAATCCAACAAGCTGCTTTTATGAAAGTTGAACTTTCGAAGCTTCAAGAACAGATGATCAAATATGGCTCAATCCAGATTTCATCAAAAGGACTGATGCGACAAACAGAAGCTGCTAAATATTATACAAAACTTGTAAACTCATATGGCACAGTTATTAAGACTTTGAATTCAATATTGGGCACGCAAGTGAATGATGGGGATGATGCTTTTGATGAATTTCTTAAAAGGGCAAATGAATGAACTATCTATTTGAATACTATCACGAAATACAAAAAGGAAATATTCTTGTTGGTGAAGAGTTAAAGAACCAGCTTGATCGCTTGATCATTGATCTTCACAACTCAAAGTATGTCTTTGATGAACAACCAGGAAAACTCAGAATTGATTTTATTGAAACATTTTGCAAACATACTAAATCACCTTTTAATGGGCAACCCTTTATATTAGAACTTTGGGAAAAGGCGATCATCCAAACTGCATATGGTTTTAAAATGGCAGATACAGGACTAAGAAGGTTTAATGAAGTTATACTTTTGATTGCACGAAAAAATGGAAAGACAACATTTATTGCAGGATTAGACCTAGCAGAGTTTTTTCTATCAAGTGGTGGTGTCGATATTGTTTGTGCTTCAAACACCACAGAACAAGCGAATATTCTATTTGAAGAGATAAATAATATGAGGGAACAATCACCATCACTCTCTAAAGATACAAGAAGCAGAAAGAATATCTTTTTCATTTACTCACCAAAAACTAAGAACAAGATTAAAAAATTATCAGCTCAATCAAGAAATAAAGATGGCTACAATATTGAAGTTGGATGTATTGATGAAGTTCATGAAATGACCGATTCAAAAGTCTATGATGCGATTAAACAATCACAGTCAACTAAAAAAGAGCCACTTATATTCATCATTACCACTGAGGGAACAACCATCGGTGGATTTTTAGATAGCAAACTAGATTATGCTAGGAAGATGATCAAAGGTGAAATAGATGATGTTCGTGTGCTTCCATGGCTTTATACACAAGACTCTGTAAAAGAGATTTATGATGATAAAAGAACCTGGCAGAAATCAAATCCAAGTATTGATGTAGTAAAGACAGCATCTTATCTTGAAGACGTCATGAATAAATCTAAACATGATTTATCAACTAGAGTTACTATGCTTTGTAAAGATTTCAATATTAAACAAGCAGATTCTGGATCATGGCTATCATTTGATGATCTGAACAATGAAGAAAAATATAGTATAGATGACTTAAGAGATAGCTATGCTATTGGTGGTGTAGACTTATCGTCGACAACCGATTTAACTGCTGCAGTTCTTATTATTCAAAAGAGAGATTCAAGTAAGAAATATGTGATTCCACATTTCTTTATGCCTAGTGAAGTTGTAGAGAAAAGAACCAAAGAAGATAATGTGCCTTATGATATTTGGGTTAAAAAGGGTTATGTAACTTTGACAGATGGTAATCAAAATGATTTTAGTCTTGTTACTAAATGGTTTATGAAGATGATTCAAACATATAGCATTAGACCATTATGGGTAGGATACGATCCTTGGAACTCGCAATATTGGATTAGGGAAATGGAAGATCTAGGATTTAATATGGAGAAAGTAAGACAAGGTATTTATTCCTTATCAGAACCTATGAAACAAATGGAAGCTGACTTAAAGAATAAACTTATAGTTTATGATAATAATCCTATTTTAAAGTGGTGTTTAGCAAATACACAAGCTAAAGTAGATTTGAATGGAAATATACAACCCTCAAAACTTAACTCAAAGTATAAAAGAATTGATGGAACTGTCGCATTGATAATTGCTTACACAGTGCTCAACAGGTATAAAATTGATTATGAAAATATGATATAA

Protein sequences of DBSCAN-SWA_1

>MIDB01000007|113092:126456|116973_117207_+|OHE44822.1|DBSCAN-SWA
MANTKKDLVAGAQDLIQDIFDLYDDYSAEDQKKIENMLCDMKDLNTHLKGYEKEEKKKPKWLLKLEKAFNDYFGKKD
>MIDB01000007|113092:126456|117181_117571_+|OHE44823.1|DBSCAN-SWA
MITSEKKTKKNEIVVSIVSGLLTIVYGVIFSLITHFNSETSHLVIKLAVWIVGIYFCIILVIGILRIFKIKFNALNYKFIFILTSLISATLAVIIAGTFELEYFVTLIAIVGLYELFKKIIKINNKHGE
>MIDB01000007|113092:126456|124495_124816_+|OHE44876.1|DBSCAN-SWA
MIEIEYKRLRSLFSSVDETKKELVDNLIQQAAFMKVELSKLQEQMIKYGSIQISSKGLMRQTEAAKYYTKLVNSYGTVIKTLNSILGTQVNDGDDAFDEFLKRANE
>MIDB01000007|113092:126456|120980_121283_+|OHE44829.1|DBSCAN-SWA
MKTRFIRKPERQDLIPQDEFIIEKVIVLDKKDFDKFLNHPLDDYDFIKENVELMYCDKENVYHCILVTSNEDDFGILIESEGYHYARYAAYISKAELRSE
>MIDB01000007|113092:126456|122774_123707_+|OHE44832.1|DBSCAN-SWA
MSDKKRNSLIDEFFQKRKVYENIKEYNDILDNLEYYSVFLDNLGKNSYEPYISVSIFNDYVPNYDFNSGNPLAPILEFLKTIKKAHVINLASIFDSLRSTLYSIHRTMEVINISDSFALLRKFKDDYLLAIFFSLLGNSNHENSGVSFEKWNEKIDTVFKFAQNSMNDLKSVEAVSFITSNPDIKELDKLIGIKSKFKEMTDLMNKYMHSHGLLFLNNTNPKRHLDSTIDMIKVFNKYLDTIMTYLTCIIIYLNPRLIVPHEYFRNMDTNDSLSEKTHRCTATYLKEFIDDRVQVVEPKLYDFLMKKFYF
>MIDB01000007|113092:126456|118892_120104_+|OHE44826.1|DBSCAN-SWA
MNLVMKKVTQLLEYENNPRNNEVAIEAVANSIKAFGFKVPIVITSEHVIIAGHTRLKAAKMLELESVPCIIADDLTEDQIKAFRLADNKTAELATWDFSKLEEELFNIDMDMLQFGFEELESLVPDNATDDDFDISDEIPETPFSELGDIYELGGHRLMCGDSTSSNDVKKLVDDVKVDMIFTDPPYNVDYEGTAGKIKNDKMEDNNFYLFLYDAFNNMFENIKPGGAIYVCHADTEGLNFRNAYKNAGFKLAECLIWVKNALVLGRQDYHWRHEPILYGWKEGAAHYFVDDRSQDTIWEYNKPRKNEEHPTMKPLELVGKAIANSSRRHETILDLFGGSGSTMIAADQLDRKSCLMELDERFVDVIVKRYIKHKTSIDDCYLIRNGKKSPLSAFEVFNNISL
>MIDB01000007|113092:126456|120179_120614_+|OHE44827.1|DBSCAN-SWA
MSKELSLRTWIEKFNQGDFDSKDLETQIKAGWYDWFCKDDSLGNKTKRMGSIVKQFKDCGKLNLDNMYVWFKNNCPLAGPLYDDFRIADIESGDTLFTIQINCFREENRYTVYGKRNDFDTPLFGTESIKELVAWMNEGWADNV
>MIDB01000007|113092:126456|122435_122720_+|OHE44831.1|DBSCAN-SWA
MKKPKILHNFYKSAAWQVARQIKYQEQDGRCERCKRVGEEVHHKIRLTIQNVSDTSVSLNQENLELLCKECHNKEHKRFSIEKEFDDEGNLIPR
>MIDB01000007|113092:126456|123819_124491_+|OHE44833.1|DBSCAN-SWA
MITTSTIARVLQIEFNGSLASSFTVESNNIQYLVSAKHLFKNIDYGDTIDLIVSAEGTKKLLNCSVYFHKEENIDIVVLKLNKNKNITQVFSTKFSSNNVILGHDAYILGFPFGMLNSDIKDSKYPAPFVKRGCISGIVKEKNANVIYADTVNNIGFSGGPMTTYEPTNFKDAYIIGVISGYRIHTSMVHDENGKETKNYVRENSGLTKAYSIEHVFEIINEL
>MIDB01000007|113092:126456|113092_116224_+|OHE44820.1|DBSCAN-SWA
MTMNHEYNELDLSQKPALEVLESLGYIILKTDEAELMRSSRYSVILEDVLKVQLQKINEFEYRGKFNRFSEKNIEQALLDIDEPLADGLIKTNEKIYNTLLLGRSYPEVVSIEDGARSFNLNFIDWLHPENNIFHAVEEYSVEREDGQSSVRPDVVLFINGIPFAVIEFKKADIPIAQAISQMIRNQGQGYVPQLFKFIQIVMSANKNLVQYATTGTPAKFWQVWKEDSSSEEYDWYEDELKKAVKNRISTIQDQNIVSLFHPDRVLDFIRYFIIFDKYDKKIARYQQYFAIKEIAKTIQETDSEGNRQSGVIWHTQGSGKSLTMVMLTKYLISEFAHLDPQIVIVTDRIELDSQIHKTFNHSRLKAAKATSGKNLVDLIRKQSVNIITSLVHKFDIASKNHTIVKSKNVFVLVDESHRTQYGELHTKMMQVFPNACYLGFTGTPLMKDEKSTMKKFGSRLIHKYTIKDGVDDKTIVPLLYEGRMVEQTINRIAIDNRLDIITRNLNEKQSEMLKKKWSHFEKIASSEQRIRLIADDIYIHFTQFYKGTPYKAILATDRKFDAVRYKDAFDEYGDIKTKVVISSPDMREGNDEVDGEPDDRVIKFWKKEVEPYGDPLKYEEYVKNEFIEGDEVDILIVVEKLLTGFDAPRASVLYVDKQLKEHSLLQAIARVNRIYEGKDFGLIVDYRGLLRPLDEAMQMYSGAGLEKYDGKDIEGALVDVVSIAAKLRGAYSYLVSVFKEVKNKNDREEFELILADDNLREEFYDNLTQFGKYLGVALESVHLYNALGEKEIGQYKKDLKYYQELRATVKIRYSDAIDHKEYEPKMRNLMDTYIAAEEVIRISAPVDILNEHDFEEELNKLGTTRAKADAIRTRMTQRIHQKYDENPTYYKKFSERIQAILDEYKERRISDADYLKHMETLKNDFRRGYSGTQYPKKIKHNNHAQAFFGVIKEAFSTESFSKGMSDDDDYKDLLADMAIEIDLIITRNSKVDWHDNPDVHKKISAEIDEYLYNIKKNSLHELTFTKIDQIIKDIKTVALRRY
>MIDB01000007|113092:126456|121318_122449_+|OHE44830.1|DBSCAN-SWA
MQRITSESVFSGHPDKVCDQISDGILDAILEQDKDARVAVETAIKDNFVFIFGEVTTTALVNYKAVAKTVLKDIGYDEEFVVMELISRQSPDIALGVNESSSKEQGAGDQGIMFGYACNETEEFMPLPIILAHRIAKGMDKARKEKYSHIFGPDGKCQVSVDYKDGKPYNIPVIVVSAQTKQGVTRAFYEDIIKAIIFNSMEQEDLIKNTRLLINPTGEFIIGGPKADSGLTGRKIIVDTYGGYARHGGGAFSGKDVSKVDRSAAYYSRFVAKAVVAANLATHCEVCLSYAIGVAEPTSILINTFDTGVTDDSEIQSLVEHVFNFKPGSMKKELDLSNIKFKELAKYGHFGRVDLPVKWEHVKDKADQLKRLYEET
>MIDB01000007|113092:126456|120606_120984_+|OHE44828.1|DBSCAN-SWA
MFKEYNAHPKGIKTTDCVVRAISTATTIDYLEVRRELNKKKKELGYSSYKDTQFLYDYLKDYPRLIFKPVKGEPRIKGTDFTELHPIGTYILKMAGHITACIDGIIYDTWDCSYRSVYTAWEIRR
>MIDB01000007|113092:126456|118432_118954_+|OHE44825.1|DBSCAN-SWA
MKGRMLDLYERWEQSGHLESRLKSISEMISKRATQKQIALYLGVTDKTLIKLRKVHPRLDKAFQYGDEELKQNLIDAMLQRAIGFEYEETQTVIEETKTGTKKRITKYKKRSLPEIAAIKYLLIVKFGLEYNDKKEEIELMNKRLEKGEEAWSNEFSHEESNPIIRIRKQSEK
>MIDB01000007|113092:126456|117567_117918_+|OHE44824.1|DBSCAN-SWA
MIIIWYKYIYEFLFQTEPLFNDFFLDWIFPAAIVFLLYDFAFGVVGGLYRAGIIRGRDLGSIIHWGIRYGMMWGTIQILIFIRDNWLYIVLAAVGAIIVFVLIGLFIRSLLMNKFI
>MIDB01000007|113092:126456|124812_126456_+|OHE44834.1|DBSCAN-SWA
MNYLFEYYHEIQKGNILVGEELKNQLDRLIIDLHNSKYVFDEQPGKLRIDFIETFCKHTKSPFNGQPFILELWEKAIIQTAYGFKMADTGLRRFNEVILLIARKNGKTTFIAGLDLAEFFLSSGGVDIVCASNTTEQANILFEEINNMREQSPSLSKDTRSRKNIFFIYSPKTKNKIKKLSAQSRNKDGYNIEVGCIDEVHEMTDSKVYDAIKQSQSTKKEPLIFIITTEGTTIGGFLDSKLDYARKMIKGEIDDVRVLPWLYTQDSVKEIYDDKRTWQKSNPSIDVVKTASYLEDVMNKSKHDLSTRVTMLCKDFNIKQADSGSWLSFDDLNNEEKYSIDDLRDSYAIGGVDLSSTTDLTAAVLIIQKRDSSKKYVIPHFFMPSEVVEKRTKEDNVPYDIWVKKGYVTLTDGNQNDFSLVTKWFMKMIQTYSIRPLWVGYDPWNSQYWIREMEDLGFNMEKVRQGIYSLSEPMKQMEADLKNKLIVYDNNPILKWCLANTQAKVDLNGNIQPSKLNSKYKRIDGTVALIIAYTVLNRYKIDYENMI
>MIDB01000007|113092:126456|116233_116962_+|OHE44821.1|DBSCAN-SWA
MSIYSIEIDKGKVIQVELVRKNVKNINLTIRPDLTIFVSAKPTLPMESIEEYIKSKSSWIVKRIGRFKATKSVNTISHEYVSGESYKFLGKQYRLDLELTASSERVMLTDGYIKLFVKNKNKKTTKSRLMDEWYRKQAKTIFEDSLDRIYTIIEPYINKKPTMDFKVMKKRWGSCLRSKNMILLNLELIKAPMYCIDYVVLHELVHFIHRNHDAKFYEMLTVLMPDWKQRKEILDEEIVLFI

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
OHE44820.1|113092_116224_+	DEAD/DEAH box helicase	A0A220A398	Liberibacter_phage	1.3e-64	24.4
OHE44821.1|116233_116962_+	hypothetical protein	NA	NA	NA	NA
OHE44822.1|116973_117207_+	hypothetical protein	NA	NA	NA	NA
OHE44823.1|117181_117571_+	hypothetical protein	NA	NA	NA	NA
OHE44824.1|117567_117918_+	hypothetical protein	NA	NA	NA	NA
OHE44825.1|118432_118954_+	hypothetical protein	A0A2K9V3J2	Faecalibacterium_phage	2.5e-05	33.3
OHE44826.1|118892_120104_+	lactate dehydrogenase	Q708N6	Streptococcus_phage	2.9e-105	50.4
OHE44827.1|120179_120614_+	hypothetical protein	NA	NA	NA	NA
OHE44828.1|120606_120984_+	hypothetical protein	W8EK91	Geobacillus_phage	1.0e-11	35.0
OHE44829.1|120980_121283_+	hypothetical protein	NA	NA	NA	NA
OHE44830.1|121318_122449_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	2.3e-88	47.7
OHE44831.1|122435_122720_+	hypothetical protein	A0A0A8WJ48	Clostridium_phage	5.8e-12	43.2
OHE44832.1|122774_123707_+	hypothetical protein	NA	NA	NA	NA
OHE44833.1|123819_124491_+	hypothetical protein	NA	NA	NA	NA
OHE44876.1|124495_124816_+	hypothetical protein	A0A290GJQ7	Caldibacillus_phage	7.5e-08	31.7
OHE44834.1|124812_126456_+	hypothetical protein	A0A290GJW3	Caldibacillus_phage	9.8e-112	38.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
MIDB01000007.1|OHE44827.1|120179_120614_+|hypothetical-protein	120179_120614_+	144 aa aa	AcrIIA11	NA	NA	113092-126456	NA

Protein sequences of MIDB01000007.1|OHE44827.1|120179_120614_+|hypothetical-protein

>MIDB01000007.1|OHE44827.1|120179_120614_+|hypothetical-protein
MSKELSLRTWIEKFNQGDFDSKDLETQIKAGWYDWFCKDDSLGNKTKRMGSIVKQFKDCGKLNLDNMYVWFKNNCPLAGPLYDDFRIADIESGDTLFTIQINCFREENRYTVYGKRNDFDTPLFGTESIKELVAWMNEGWADNV

anti_CRISPR1287|OHE28210.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-GWC2_34_14-(subsurface-metagenome) information

• hit_Aca_id: anti_CRISPR1287|OHE28210.1|AcrIIA11|II-A|Verified|Tenericutes-bacterium-GWC2_34_14-(subsurface-metagenome)
• identity: 1.0
• query_coverage: 1
• hit_coverage: 1.0