assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_009866745.1_ASM986674v1	NZ_CP019398	Pseudomonas sp. S34 chromosome, complete genome	1	342928-343033	1	CRISPRCasFinder	no		PD-DExK,DEDDh,DinG,csa3,RT,cas3	Orphan	GGCTCGTCGCGAGTGCGGTGTGAGCC	26	0	0	NA	NA	NA	1	1	Orphan	PD-DExK,DEDDh,DinG,csa3,RT,cas3	NA|147aa|up_0|NZ_CP019398.1_342440_342881_+,NA	NA|252aa|up_9|NZ_CP019398.1_334414_335170_+	COG0834, HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]	NA|259aa|up_8|NZ_CP019398.1_335301_336078_-	pfam04748, Polysacc_deac_2, Divergent polysaccharide deacetylase	NA|440aa|up_7|NZ_CP019398.1_336079_337399_-	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane]	NA|432aa|up_6|NZ_CP019398.1_337433_338729_-	COG4942, COG4942, Membrane-bound metallopeptidase [Cell division and chromosome partitioning]	NA|510aa|up_5|NZ_CP019398.1_338959_340489_-	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase	NA|138aa|up_4|NZ_CP019398.1_340642_341056_+	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein	NA|85aa|up_3|NZ_CP019398.1_341057_341312_+	TIGR02181, GRX_bact, Glutaredoxin, GrxC family	NA|162aa|up_2|NZ_CP019398.1_341368_341854_+	PRK05751, PRK05751, preprotein translocase subunit SecB; Validated	NA|152aa|up_1|NZ_CP019398.1_341986_342442_-	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]	NA|147aa|up_0|NZ_CP019398.1_342440_342881_+	NA	NA|479aa|down_0|NZ_CP019398.1_343491_344928_-	TIGR01818, Nitrogen_assimilation_regulatory_protein, nitrogen regulation protein NR(I)	NA|362aa|down_1|NZ_CP019398.1_344924_346010_-	COG3852, NtrB, Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]	NA|207aa|down_2|NZ_CP019398.1_346237_346858_-	pfam13511, DUF4124, Domain of unknown function (DUF4124)	NA|172aa|down_3|NZ_CP019398.1_346854_347370_-	pfam13511, DUF4124, Domain of unknown function (DUF4124)	NA|469aa|down_4|NZ_CP019398.1_347668_349075_-	PRK09469, glnA, glutamate--ammonia ligase	NA|485aa|down_5|NZ_CP019398.1_349403_350858_+	PRK01269, PRK01269, tRNA s(4)U8 sulfurtransferase; Provisional	NA|607aa|down_6|NZ_CP019398.1_350997_352818_+	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]	NA|146aa|down_7|NZ_CP019398.1_353038_353476_-	pfam03692, CxxCxxCC, Putative zinc- or iron-chelating domain	NA|817aa|down_8|NZ_CP019398.1_353731_356182_+	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins	NA|1069aa|down_9|NZ_CP019398.1_356472_359679_+	COG5373, COG5373, Predicted membrane protein [Function unknown]
GCF_009866745.1_ASM986674v1	NZ_CP019398	Pseudomonas sp. S34 chromosome, complete genome	2	715181-715274	2	CRISPRCasFinder	no		PD-DExK,DEDDh,DinG,csa3,RT,cas3	Orphan	TGTGGGAGCGGGCTTGCTCGCGAAG	25	0	0	NA	NA	NA	1	1	Orphan	PD-DExK,DEDDh,DinG,csa3,RT,cas3	NA|98aa|up_5|NZ_CP019398.1_708903_709197_-,NA|119aa|down_0|NZ_CP019398.1_715671_716028_+,NA|128aa|down_8|NZ_CP019398.1_726722_727106_-	NA|638aa|up_9|NZ_CP019398.1_703096_705010_+	PRK05354, PRK05354, biosynthetic arginine decarboxylase	NA|440aa|up_8|NZ_CP019398.1_705242_706562_+	TIGR03361, VI_Rhs_Vgr, type VI secretion system Vgr family protein	NA|267aa|up_7|NZ_CP019398.1_706558_707359_+	pfam13503, DUF4123, Domain of unknown function (DUF4123)	NA|450aa|up_6|NZ_CP019398.1_707390_708740_-	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins	NA|98aa|up_5|NZ_CP019398.1_708903_709197_-	NA	NA|101aa|up_4|NZ_CP019398.1_709459_709762_+	cd11537, NTP-PPase_RS21-C6_like, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3	NA|250aa|up_3|NZ_CP019398.1_709761_710511_+	PRK11036, PRK11036, tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM	NA|203aa|up_2|NZ_CP019398.1_710523_711132_+	pfam13590, DUF4136, Domain of unknown function (DUF4136)	NA|188aa|up_1|NZ_CP019398.1_711187_711751_+	pfam13590, DUF4136, Domain of unknown function (DUF4136)	NA|923aa|up_0|NZ_CP019398.1_711859_714628_-	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]	NA|119aa|down_0|NZ_CP019398.1_715671_716028_+	NA	NA|285aa|down_1|NZ_CP019398.1_716086_716941_-	pfam01575, MaoC_dehydratas, MaoC like domain	NA|451aa|down_2|NZ_CP019398.1_716943_718296_-	PRK08261, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional	NA|426aa|down_3|NZ_CP019398.1_718519_719797_+	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase	NA|649aa|down_4|NZ_CP019398.1_720187_722134_-	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]	NA|298aa|down_5|NZ_CP019398.1_722579_723473_+	COG1718, RIO1, Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]	NA|138aa|down_6|NZ_CP019398.1_723709_724123_-	cd01108, HTH_CueR, Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators	NA|798aa|down_7|NZ_CP019398.1_724119_726513_-	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B	NA|128aa|down_8|NZ_CP019398.1_726722_727106_-	NA	NA|66aa|down_9|NZ_CP019398.1_727255_727453_+	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism]
GCF_009866745.1_ASM986674v1	NZ_CP019398	Pseudomonas sp. S34 chromosome, complete genome	3	2280554-2280664	3	CRISPRCasFinder	no		PD-DExK,DEDDh,DinG,csa3,RT,cas3	Orphan	TGTAGCTTAGTTGGTTAGAGCGCACCCC	28	0	0	NA	NA	NA	1	1	Orphan	PD-DExK,DEDDh,DinG,csa3,RT,cas3	NA,NA|254aa|down_0|NZ_CP019398.1_2284394_2285156_-,NA|143aa|down_1|NZ_CP019398.1_2285195_2285624_-	NA|222aa|up_9|NZ_CP019398.1_2265090_2265756_-	COG0684, MenG, Demethylmenaquinone methyltransferase [Coenzyme metabolism]	NA|298aa|up_8|NZ_CP019398.1_2265861_2266755_+	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold	NA|273aa|up_7|NZ_CP019398.1_2266911_2267730_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|485aa|up_6|NZ_CP019398.1_2267882_2269337_+	pfam01235, Na_Ala_symp, Sodium:alanine symporter family	NA|459aa|up_5|NZ_CP019398.1_2269398_2270775_-	PRK10406, PRK10406, alpha-ketoglutarate transporter; Provisional	NA|314aa|up_4|NZ_CP019398.1_2271264_2272206_+	cd08433, PBP2_Nac, The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold	NA|370aa|up_3|NZ_CP019398.1_2272371_2273481_+	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters	NA|464aa|up_2|NZ_CP019398.1_2273588_2274980_-	PRK13968, PRK13968, putative succinate semialdehyde dehydrogenase; Provisional	NA|293aa|up_1|NZ_CP019398.1_2275080_2275959_+	cd08442, PBP2_YofA_SoxR_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold	NA|735aa|up_0|NZ_CP019398.1_2276036_2278241_+	TIGR03549, TIGR03549, YcaO domain protein	NA|254aa|down_0|NZ_CP019398.1_2284394_2285156_-	NA	NA|143aa|down_1|NZ_CP019398.1_2285195_2285624_-	NA	NA|138aa|down_2|NZ_CP019398.1_2285762_2286176_-	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins	NA|220aa|down_3|NZ_CP019398.1_2286265_2286925_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|284aa|down_4|NZ_CP019398.1_2286911_2287763_-	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated	NA|354aa|down_5|NZ_CP019398.1_2287926_2288988_+	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term	NA|241aa|down_6|NZ_CP019398.1_2289105_2289828_-	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain	NA|317aa|down_7|NZ_CP019398.1_2290145_2291096_+	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]	NA|495aa|down_8|NZ_CP019398.1_2291247_2292732_+	COG3903, COG3903, Predicted ATPase [General function prediction only]	NA|935aa|down_9|NZ_CP019398.1_2292696_2295501_-	COG3903, COG3903, Predicted ATPase [General function prediction only]
GCF_009866745.1_ASM986674v1	NZ_CP019398	Pseudomonas sp. S34 chromosome, complete genome	4	2418248-2418340	4	CRISPRCasFinder	no		PD-DExK,DEDDh,DinG,csa3,RT,cas3	Orphan	CTGTGGGAGCGAGCTTGCTCGCGA	24	0	0	NA	NA	NA	1	1	Orphan	PD-DExK,DEDDh,DinG,csa3,RT,cas3	NA|126aa|up_5|NZ_CP019398.1_2412116_2412494_-,NA|193aa|down_8|NZ_CP019398.1_2431547_2432126_+	NA|482aa|up_9|NZ_CP019398.1_2406369_2407815_+	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|372aa|up_8|NZ_CP019398.1_2407999_2409115_+	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold	NA|498aa|up_7|NZ_CP019398.1_2409217_2410711_+	PRK10364, PRK10364, two-component system sensor histidine kinase ZraS	NA|478aa|up_6|NZ_CP019398.1_2410679_2412113_+	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]	NA|126aa|up_5|NZ_CP019398.1_2412116_2412494_-	NA	NA|269aa|up_4|NZ_CP019398.1_2412665_2413472_+	pfam13649, Methyltransf_25, Methyltransferase domain	NA|347aa|up_3|NZ_CP019398.1_2413856_2414897_-	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term	NA|305aa|up_2|NZ_CP019398.1_2414968_2415883_+	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold	NA|306aa|up_1|NZ_CP019398.1_2416000_2416918_-	COG0583, LysR, Transcriptional regulator [Transcription]	NA|280aa|up_0|NZ_CP019398.1_2417015_2417855_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|609aa|down_0|NZ_CP019398.1_2418784_2420611_+	pfam06980, DUF1302, Protein of unknown function (DUF1302)	NA|446aa|down_1|NZ_CP019398.1_2420622_2421960_+	pfam07044, DUF1329, Protein of unknown function (DUF1329)	NA|450aa|down_2|NZ_CP019398.1_2422123_2423473_+	COG5361, COG5361, Uncharacterized conserved protein [Function unknown]	NA|462aa|down_3|NZ_CP019398.1_2423469_2424855_+	COG5361, COG5361, Uncharacterized conserved protein [Function unknown]	NA|658aa|down_4|NZ_CP019398.1_2425099_2427073_-	COG2015, COG2015, Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]	NA|223aa|down_5|NZ_CP019398.1_2427210_2427879_+	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein	NA|824aa|down_6|NZ_CP019398.1_2427880_2430352_+	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]	NA|358aa|down_7|NZ_CP019398.1_2430341_2431415_+	COG5621, COG5621, Predicted secreted hydrolase [General function prediction only]	NA|193aa|down_8|NZ_CP019398.1_2431547_2432126_+	NA	NA|465aa|down_9|NZ_CP019398.1_2432487_2433882_-	cd16348, VOC_YdcJ_like, uncharacterized metal-dependent enzyme similar to Shigella flexneri YdcJ
GCF_009866745.1_ASM986674v1	NZ_CP019398	Pseudomonas sp. S34 chromosome, complete genome	5	3798065-3798578	5	CRISPRCasFinder	no		PD-DExK,DEDDh,DinG,csa3,RT,cas3	Orphan	CGCCGCCATTGAGGACGTCGTTGCC	25	0	0	NA	NA	NA	7	7	Orphan	PD-DExK,DEDDh,DinG,csa3,RT,cas3	NA,NA	NA|137aa|up_9|NZ_CP019398.1_3786034_3786445_-	COG0251, TdcF, Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis]	NA|454aa|up_8|NZ_CP019398.1_3786444_3787806_-	TIGR04046, predicted_flavoprotein_involved_in_K+_transport, flavin-dependent oxidoreductase, MSMEG_0569 family	NA|459aa|up_7|NZ_CP019398.1_3788082_3789459_+	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism]	NA|393aa|up_6|NZ_CP019398.1_3789455_3790634_+	COG0626, MetC, Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]	NA|284aa|up_5|NZ_CP019398.1_3790910_3791762_+	TIGR04553, ABC_peri_selen, putative selenate ABC transporter periplasmic binding protein	NA|266aa|up_4|NZ_CP019398.1_3791758_3792556_+	COG3638, COG3638, ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]	NA|276aa|up_3|NZ_CP019398.1_3792549_3793377_+	COG3639, COG3639, ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]	NA|256aa|up_2|NZ_CP019398.1_3793373_3794141_+	TIGR01097, PhnE, phosphonate ABC transporter, permease protein PhnE	NA|272aa|up_1|NZ_CP019398.1_3794710_3795526_+	cd07576, R-amidase_like, Pseudomonas sp	NA|367aa|up_0|NZ_CP019398.1_3795656_3796757_+	cd13659, PBP2_PotF, The periplasmic substrate-binding component of an ABC putrescine transport system and related proteins; contains the type 2 periplasmic-binding fold	NA|154aa|down_0|NZ_CP019398.1_3799553_3800015_-	COG3767, COG3767, Uncharacterized low-complexity protein [Function unknown]	NA|123aa|down_1|NZ_CP019398.1_3800278_3800647_+	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]	NA|339aa|down_2|NZ_CP019398.1_3800843_3801860_-	cd06250, M14_PaAOTO_like, Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO	NA|212aa|down_3|NZ_CP019398.1_3801973_3802609_+	TIGR03384, betaine_BetI, transcriptional repressor BetI	NA|233aa|down_4|NZ_CP019398.1_3803472_3804171_-	COG4160, ArtM, ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]	NA|238aa|down_5|NZ_CP019398.1_3804176_3804890_-	COG4215, ArtQ, ABC-type arginine transport system, permease component [Amino acid transport and metabolism]	NA|261aa|down_6|NZ_CP019398.1_3805045_3805828_-	cd13701, PBP2_ml15202_like, Substrate binding domain of ABC-type histidine/lysine/arginine/ornithine transporter-like; the type 2 periplasmic-binding protein fold	NA|668aa|down_7|NZ_CP019398.1_3805855_3807859_-	COG4598, HisP, ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]	NA|481aa|down_8|NZ_CP019398.1_3807975_3809418_-	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily	NA|295aa|down_9|NZ_CP019398.1_3809695_3810580_+	cd08460, PBP2_DntR_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold
GCF_009866745.1_ASM986674v1	NZ_CP019398	Pseudomonas sp. S34 chromosome, complete genome	6	5047889-5048071	1	PILER-CR	no		PD-DExK,DEDDh,DinG,csa3,RT,cas3	Orphan	TCGGCTGTCAGGCCGCCTTCGCGAGCAAGCCCGCTCCCACAG	42	0	0	NA	NA	NA	2	2	Orphan	PD-DExK,DEDDh,DinG,csa3,RT,cas3	NA|88aa|up_0|NZ_CP019398.1_5047213_5047477_-,NA	NA|398aa|up_9|NZ_CP019398.1_5038211_5039405_+	PRK08243, PRK08243, 4-hydroxybenzoate 3-monooxygenase; Validated	NA|506aa|up_8|NZ_CP019398.1_5039483_5041001_+	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily	NA|283aa|up_7|NZ_CP019398.1_5041124_5041973_-	pfam08269, dCache_2, Cache domain	NA|291aa|up_6|NZ_CP019398.1_5042222_5043095_-	TIGR04211, hypothetical_protein, SH3 domain protein	NA|331aa|up_5|NZ_CP019398.1_5043211_5044204_-	cd05241, 3b-HSD-like_SDR_e, 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs	NA|298aa|up_4|NZ_CP019398.1_5044258_5045152_-	PRK03635, PRK03635, ArgP/LysG family DNA-binding transcriptional regulator	NA|134aa|up_3|NZ_CP019398.1_5045248_5045650_+	COG3602, COG3602, Uncharacterized protein conserved in bacteria [Function unknown]	NA|201aa|up_2|NZ_CP019398.1_5045656_5046259_+	COG1279, COG1279, Lysine efflux permease [General function prediction only]	NA|199aa|up_1|NZ_CP019398.1_5046423_5047020_+	PRK10543, PRK10543, superoxide dismutase [Fe]	NA|88aa|up_0|NZ_CP019398.1_5047213_5047477_-	NA	NA|684aa|down_0|NZ_CP019398.1_5048732_5050784_+	cd01948, EAL, EAL domain	NA|450aa|down_1|NZ_CP019398.1_5051025_5052375_+	COG3487, IrpA, Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]	NA|476aa|down_2|NZ_CP019398.1_5052652_5054080_+	COG3488, COG3488, Predicted thiol oxidoreductase [Energy production and conversion]	NA|355aa|down_3|NZ_CP019398.1_5054107_5055172_+	COG3489, COG3489, Predicted periplasmic lipoprotein [General function prediction only]	NA|367aa|down_4|NZ_CP019398.1_5055186_5056287_+	COG3490, COG3490, Uncharacterized protein conserved in bacteria [Function unknown]	NA|383aa|down_5|NZ_CP019398.1_5056487_5057636_+	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit	NA|1009aa|down_6|NZ_CP019398.1_5057649_5060676_+	PRK09579, PRK09579, multidrug efflux RND transporter permease subunit	NA|238aa|down_7|NZ_CP019398.1_5061089_5061803_-	PRK09902, PRK09902, lipopolysaccharide kinase InaA	NA|223aa|down_8|NZ_CP019398.1_5061807_5062476_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|425aa|down_9|NZ_CP019398.1_5062630_5063905_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]
