assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	1	56776-56854	1	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TGTTTATAATGTGGATAATATTTAA	25	0	0	NA	NA	NA	1	1	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|226aa|down_4|NZ_CP025046.1_73737_74415_+	NA|278aa|up_9|NZ_CP025046.1_33736_34570_+	TIGR04520, ECF_ATPase_1, energy-coupling factor transporter ATPase	NA|289aa|up_8|NZ_CP025046.1_34557_35424_+	PRK13637, cbiO, energy-coupling factor transporter ATPase	NA|268aa|up_7|NZ_CP025046.1_35417_36221_+	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]	NA|244aa|up_6|NZ_CP025046.1_36252_36984_+	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA	NA|144aa|up_5|NZ_CP025046.1_37103_37535_+	PRK09216, rplM, 50S ribosomal protein L13; Reviewed	NA|131aa|up_4|NZ_CP025046.1_37563_37956_+	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed	NA|251aa|up_3|NZ_CP025046.1_38414_39167_+	TIGR02883, spore_cwlD, N-acetylmuramoyl-L-alanine amidase CwlD	NA|395aa|up_2|NZ_CP025046.1_51825_53010_-	PRK05764, PRK05764, aspartate aminotransferase; Provisional	NA|784aa|up_1|NZ_CP025046.1_53382_55734_+	PRK07111, PRK07111, anaerobic ribonucleoside triphosphate reductase; Provisional	NA|180aa|up_0|NZ_CP025046.1_55755_56295_+	TIGR02491, Anaerobic_ribonucleoside-triphosphate_reductase, anaerobic ribonucleoside-triphosphate reductase activating protein	NA|280aa|down_0|NZ_CP025046.1_69423_70263_+	COG1624, COG1624, Uncharacterized conserved protein [Function unknown]	NA|394aa|down_1|NZ_CP025046.1_70259_71441_+	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown]	NA|301aa|down_2|NZ_CP025046.1_71744_72647_+	PRK05805, PRK05805, phosphate butyryltransferase; Validated	NA|360aa|down_3|NZ_CP025046.1_72668_73748_+	PRK03011, PRK03011, butyrate kinase; Provisional	NA|226aa|down_4|NZ_CP025046.1_73737_74415_+	NA	NA|72aa|down_5|NZ_CP025046.1_74457_74673_+	COG2221, DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]	NA|360aa|down_6|NZ_CP025046.1_74701_75781_+	PRK07119, PRK07119, 2-ketoisovalerate ferredoxin reductase; Validated	NA|251aa|down_7|NZ_CP025046.1_75780_76533_+	cd03375, TPP_OGFOR, Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor	NA|186aa|down_8|NZ_CP025046.1_76533_77091_+	pfam01558, POR, Pyruvate ferredoxin/flavodoxin oxidoreductase	NA|449aa|down_9|NZ_CP025046.1_77260_78607_+	PRK14316, glmM, phosphoglucosamine mutase; Provisional
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	2	58788-58877	2	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TGTGCGTTAGCACTTTAAGCAACAGAAT	28	1	5	58816-58849|58816-58849|58816-58849|58816-58849|58816-58849	NZ_CP025046.1_41193-41226|NZ_CP025046.1_48205-48238|NZ_CP025046.1_64268-64301|NZ_CP025046.1_2941749-2941716|NZ_CP025046.1_4116090-4116123	NA	1	1	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|226aa|down_4|NZ_CP025046.1_73737_74415_+	NA|278aa|up_9|NZ_CP025046.1_33736_34570_+	TIGR04520, ECF_ATPase_1, energy-coupling factor transporter ATPase	NA|289aa|up_8|NZ_CP025046.1_34557_35424_+	PRK13637, cbiO, energy-coupling factor transporter ATPase	NA|268aa|up_7|NZ_CP025046.1_35417_36221_+	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]	NA|244aa|up_6|NZ_CP025046.1_36252_36984_+	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA	NA|144aa|up_5|NZ_CP025046.1_37103_37535_+	PRK09216, rplM, 50S ribosomal protein L13; Reviewed	NA|131aa|up_4|NZ_CP025046.1_37563_37956_+	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed	NA|251aa|up_3|NZ_CP025046.1_38414_39167_+	TIGR02883, spore_cwlD, N-acetylmuramoyl-L-alanine amidase CwlD	NA|395aa|up_2|NZ_CP025046.1_51825_53010_-	PRK05764, PRK05764, aspartate aminotransferase; Provisional	NA|784aa|up_1|NZ_CP025046.1_53382_55734_+	PRK07111, PRK07111, anaerobic ribonucleoside triphosphate reductase; Provisional	NA|180aa|up_0|NZ_CP025046.1_55755_56295_+	TIGR02491, Anaerobic_ribonucleoside-triphosphate_reductase, anaerobic ribonucleoside-triphosphate reductase activating protein	NA|280aa|down_0|NZ_CP025046.1_69423_70263_+	COG1624, COG1624, Uncharacterized conserved protein [Function unknown]	NA|394aa|down_1|NZ_CP025046.1_70259_71441_+	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown]	NA|301aa|down_2|NZ_CP025046.1_71744_72647_+	PRK05805, PRK05805, phosphate butyryltransferase; Validated	NA|360aa|down_3|NZ_CP025046.1_72668_73748_+	PRK03011, PRK03011, butyrate kinase; Provisional	NA|226aa|down_4|NZ_CP025046.1_73737_74415_+	NA	NA|72aa|down_5|NZ_CP025046.1_74457_74673_+	COG2221, DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]	NA|360aa|down_6|NZ_CP025046.1_74701_75781_+	PRK07119, PRK07119, 2-ketoisovalerate ferredoxin reductase; Validated	NA|251aa|down_7|NZ_CP025046.1_75780_76533_+	cd03375, TPP_OGFOR, Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor	NA|186aa|down_8|NZ_CP025046.1_76533_77091_+	pfam01558, POR, Pyruvate ferredoxin/flavodoxin oxidoreductase	NA|449aa|down_9|NZ_CP025046.1_77260_78607_+	PRK14316, glmM, phosphoglucosamine mutase; Provisional
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	3	1428596-1429220	1,3,1	PILER-CR,CRISPRCasFinder,CRT	no	DinG	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Type IV-A	GTTTTATATTAACTAAGTGGTATGTAAAT,GTTTTATATTAACTAAGTGGTATGTAAAT,GTTTTATATTAACTAAGTGGTATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	8,9,8	9	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA|82aa|up_1|NZ_CP025046.1_1427091_1427337_-,NA|35aa|up_0|NZ_CP025046.1_1427961_1428066_+,NA|80aa|down_4|NZ_CP025046.1_1436343_1436583_+,NA|59aa|down_5|NZ_CP025046.1_1436770_1436947_-	NA|195aa|up_9|NZ_CP025046.1_1416769_1417354_-	pfam00882, Zn_dep_PLPC, Zinc dependent phospholipase C	NA|477aa|up_8|NZ_CP025046.1_1417553_1418984_-	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]	NA|315aa|up_7|NZ_CP025046.1_1419301_1420246_+	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter	NA|312aa|up_6|NZ_CP025046.1_1420516_1421452_-	COG1242, COG1242, Predicted Fe-S oxidoreductase [General function prediction only]	NA|198aa|up_5|NZ_CP025046.1_1421570_1422164_-	COG3247, HdeD, Uncharacterized conserved protein [Function unknown]	NA|143aa|up_4|NZ_CP025046.1_1422270_1422699_+	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ	NA|223aa|up_3|NZ_CP025046.1_1422765_1423434_+	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily	NA|452aa|up_2|NZ_CP025046.1_1423551_1424907_-	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA	NA|82aa|up_1|NZ_CP025046.1_1427091_1427337_-	NA	NA|35aa|up_0|NZ_CP025046.1_1427961_1428066_+	NA	NA|578aa|down_0|NZ_CP025046.1_1429545_1431279_-	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|278aa|down_1|NZ_CP025046.1_1431518_1432352_-	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|745aa|down_2|NZ_CP025046.1_1432382_1434617_-	cd01948, EAL, EAL domain	NA|270aa|down_3|NZ_CP025046.1_1435400_1436210_+	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators	NA|80aa|down_4|NZ_CP025046.1_1436343_1436583_+	NA	NA|59aa|down_5|NZ_CP025046.1_1436770_1436947_-	NA	NA|225aa|down_6|NZ_CP025046.1_1437451_1438126_-	COG1285, SapB, Uncharacterized membrane protein [Function unknown]	NA|185aa|down_7|NZ_CP025046.1_1438345_1438900_-	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases	NA|122aa|down_8|NZ_CP025046.1_1438977_1439343_-	COG1733, COG1733, Predicted transcriptional regulators [Transcription]	NA|262aa|down_9|NZ_CP025046.1_1439807_1440593_+	COG3393, COG3393, Predicted acetyltransferase [General function prediction only]
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	4	1539447-1540270	4,2	CRISPRCasFinder,CRT	no	cas14j	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Unclear	GTTTTATATTAACTATATGGAATGTAAAT,GTTTTATATTAACTATATGGAATGTAAAT	29,29	1	1	1540005-1540041	NZ_CP025046.1_1793170-1793206	I-A:I-A	12,12	12	TypeV	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA|50aa|up_9|NZ_CP025046.1_1528273_1528423_+,NA|190aa|up_7|NZ_CP025046.1_1529337_1529907_+,NA|61aa|up_4|NZ_CP025046.1_1532856_1533039_-,NA|95aa|down_0|NZ_CP025046.1_1540427_1540712_-,NA|330aa|down_5|NZ_CP025046.1_1545161_1546151_+	NA|50aa|up_9|NZ_CP025046.1_1528273_1528423_+	NA	NA|300aa|up_8|NZ_CP025046.1_1528433_1529333_+	TIGR02163, Ferredoxin-type_protein_NapH_homolog, ferredoxin-type protein, NapH/MauN family	NA|190aa|up_7|NZ_CP025046.1_1529337_1529907_+	NA	NA|216aa|up_6|NZ_CP025046.1_1530073_1530721_-	pfam02589, LUD_dom, LUD domain	NA|305aa|up_5|NZ_CP025046.1_1531110_1532025_-	pfam11155, DUF2935, Domain of unknown function (DUF2935)	NA|61aa|up_4|NZ_CP025046.1_1532856_1533039_-	NA	NA|283aa|up_3|NZ_CP025046.1_1533449_1534298_-	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed	NA|276aa|up_2|NZ_CP025046.1_1534316_1535144_-	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed	NA|308aa|up_1|NZ_CP025046.1_1535118_1536042_-	pfam10728, DUF2520, Domain of unknown function (DUF2520)	NA|698aa|up_0|NZ_CP025046.1_1536694_1538788_+	cd01948, EAL, EAL domain	NA|95aa|down_0|NZ_CP025046.1_1540427_1540712_-	NA	NA|273aa|down_1|NZ_CP025046.1_1540918_1541737_+	cd04782, HTH_BltR, Helix-Turn-Helix DNA binding domain of the BltR transcription regulator	NA|707aa|down_2|NZ_CP025046.1_1541869_1543990_-	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism]	NA|76aa|down_3|NZ_CP025046.1_1544015_1544243_-	pfam04023, FeoA, FeoA domain	NA|147aa|down_4|NZ_CP025046.1_1544569_1545010_-	COG2153, ElaA, Predicted acyltransferase [General function prediction only]	NA|330aa|down_5|NZ_CP025046.1_1545161_1546151_+	NA	NA|403aa|down_6|NZ_CP025046.1_1546627_1547836_+	PRK13354, PRK13354, tyrosyl-tRNA synthetase; Provisional	NA|294aa|down_7|NZ_CP025046.1_1547896_1548778_-	cd10944, CE4_SmPgdA_like, Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins	NA|315aa|down_8|NZ_CP025046.1_1549163_1550108_+	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]	NA|182aa|down_9|NZ_CP025046.1_1550330_1550876_+	cd01046, Rubrerythrin_like, rubrerythrin-like, diiron-binding domain
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	5	1716952-1718101	2,5,3	PILER-CR,CRISPRCasFinder,CRT	no	cas14j	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Unclear	GTTTTATATTAACTATGTGGTATGTAAAT,GTTTTATATTAACTATGTGGTATGTAAAT,GTTTTATATTAACTATGTGGTATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	14,17,17	17	TypeV	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|96aa|down_0|NZ_CP025046.1_1718509_1718797_+,NA|59aa|down_5|NZ_CP025046.1_1725187_1725364_-,NA|341aa|down_6|NZ_CP025046.1_1725938_1726961_+,NA|258aa|down_8|NZ_CP025046.1_1727867_1728641_+	NA|329aa|up_9|NZ_CP025046.1_1699165_1700152_-	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase	NA|577aa|up_8|NZ_CP025046.1_1700635_1702366_+	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion]	NA|172aa|up_7|NZ_CP025046.1_1702890_1703406_+	pfam13787, HXXEE, Protein of unknown function with HXXEE motif	NA|825aa|up_6|NZ_CP025046.1_1704211_1706686_+	PRK00451, PRK00451, aminomethyl-transferring glycine dehydrogenase subunit GcvPA	NA|486aa|up_5|NZ_CP025046.1_1706685_1708143_+	PRK04366, PRK04366, aminomethyl-transferring glycine dehydrogenase subunit GcvPB	NA|786aa|up_4|NZ_CP025046.1_1708565_1710923_+	cd02609, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7	NA|106aa|up_3|NZ_CP025046.1_1711008_1711326_-	pfam06865, DUF1255, Protein of unknown function (DUF1255)	cas14j|373aa|up_2|NZ_CP025046.1_1712344_1713463_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|252aa|up_1|NZ_CP025046.1_1713638_1714394_+	pfam12395, DUF3658, Protein of unknown function	NA|424aa|up_0|NZ_CP025046.1_1715033_1716305_-	cd01303, GDEase, Guanine deaminase (GDEase)	NA|96aa|down_0|NZ_CP025046.1_1718509_1718797_+	NA	NA|184aa|down_1|NZ_CP025046.1_1719335_1719887_-	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain	NA|321aa|down_2|NZ_CP025046.1_1720077_1721040_+	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase	NA|615aa|down_3|NZ_CP025046.1_1721334_1723179_+	cd08579, GDPD_memb_like, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases	NA|195aa|down_4|NZ_CP025046.1_1723500_1724085_+	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates	NA|59aa|down_5|NZ_CP025046.1_1725187_1725364_-	NA	NA|341aa|down_6|NZ_CP025046.1_1725938_1726961_+	NA	NA|296aa|down_7|NZ_CP025046.1_1726974_1727862_+	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component	NA|258aa|down_8|NZ_CP025046.1_1727867_1728641_+	NA	NA|242aa|down_9|NZ_CP025046.1_1728752_1729478_+	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	6	2034796-2034963	3	PILER-CR	no	csa3	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Type I-A	AGTTTTATATCAACTATGTGGTATGTAAAGTTTTTA	36	0	0	NA	NA	I-A	2	2	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA|133aa|up_3|NZ_CP025046.1_2031305_2031704_-,NA|59aa|up_1|NZ_CP025046.1_2033835_2034012_+,NA|55aa|down_2|NZ_CP025046.1_2036510_2036675_-,NA|17aa|down_6|NZ_CP025046.1_2039100_2039151_+	NA|119aa|up_9|NZ_CP025046.1_2022524_2022881_-	COG1733, COG1733, Predicted transcriptional regulators [Transcription]	NA|204aa|up_8|NZ_CP025046.1_2024280_2024892_+	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|113aa|up_7|NZ_CP025046.1_2025189_2025528_+	pfam12650, DUF3784, Domain of unknown function (DUF3784)	NA|479aa|up_6|NZ_CP025046.1_2025934_2027371_-	PRK14328, PRK14328, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional	NA|487aa|up_5|NZ_CP025046.1_2027618_2029079_-	NF033435, S-layer_Clost, S-layer protein SlpA	NA|184aa|up_4|NZ_CP025046.1_2029905_2030457_-	pfam17099, TrpP, Tryptophan transporter TrpP	NA|133aa|up_3|NZ_CP025046.1_2031305_2031704_-	NA	NA|162aa|up_2|NZ_CP025046.1_2032059_2032545_-	pfam08239, SH3_3, Bacterial SH3 domain	NA|59aa|up_1|NZ_CP025046.1_2033835_2034012_+	NA	NA|67aa|up_0|NZ_CP025046.1_2034237_2034438_+	COG1278, CspC, Cold shock proteins [Transcription]	NA|61aa|down_0|NZ_CP025046.1_2035188_2035371_+	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons	NA|282aa|down_1|NZ_CP025046.1_2035441_2036287_+	pfam13026, DUF3887, Protein of unknown function (DUF3887)	NA|55aa|down_2|NZ_CP025046.1_2036510_2036675_-	NA	NA|111aa|down_3|NZ_CP025046.1_2037216_2037549_-	pfam02627, CMD, Carboxymuconolactone decarboxylase family	NA|214aa|down_4|NZ_CP025046.1_2037792_2038434_-	COG5658, COG5658, Predicted integral membrane protein [Function unknown]	csa3|98aa|down_5|NZ_CP025046.1_2038414_2038708_-	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors	NA|17aa|down_6|NZ_CP025046.1_2039100_2039151_+	NA	NA|251aa|down_7|NZ_CP025046.1_2039676_2040429_-	PRK10621, PRK10621, hypothetical protein; Provisional	NA|552aa|down_8|NZ_CP025046.1_2040487_2042143_-	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]	NA|360aa|down_9|NZ_CP025046.1_2043414_2044494_-	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	7	2416050-2416731	6,4,4	CRISPRCasFinder,CRT,PILER-CR	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TTTTACATTCCATATAGTTAATCTAAAAC,TTTACATTCCATATAGTTAATCTAAAAC,GTTTTAGATTAACTATATGGAATGTAAA	29,28,28	0	0	NA	NA	NA:NA:NA	10,10,9	10	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA|138aa|up_5|NZ_CP025046.1_2412302_2412716_+,NA|99aa|up_4|NZ_CP025046.1_2412734_2413031_+,NA|106aa|up_3|NZ_CP025046.1_2413313_2413631_+,NA|155aa|up_2|NZ_CP025046.1_2413766_2414231_+,NA|54aa|up_1|NZ_CP025046.1_2414559_2414721_-,NA|51aa|up_0|NZ_CP025046.1_2415706_2415859_-,NA|51aa|down_1|NZ_CP025046.1_2418114_2418267_-,NA|108aa|down_2|NZ_CP025046.1_2418540_2418864_-,NA|85aa|down_3|NZ_CP025046.1_2418899_2419154_-,NA|57aa|down_6|NZ_CP025046.1_2422937_2423108_+,NA|59aa|down_9|NZ_CP025046.1_2424810_2424987_+	NA|687aa|up_9|NZ_CP025046.1_2407932_2409993_-	cd16923, HATPase_VanS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS	NA|231aa|up_8|NZ_CP025046.1_2410188_2410881_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|125aa|up_7|NZ_CP025046.1_2411492_2411867_-	pfam03965, Penicillinase_R, Penicillinase repressor	NA|78aa|up_6|NZ_CP025046.1_2412085_2412319_+	COG1476, COG1476, Predicted transcriptional regulators [Transcription]	NA|138aa|up_5|NZ_CP025046.1_2412302_2412716_+	NA	NA|99aa|up_4|NZ_CP025046.1_2412734_2413031_+	NA	NA|106aa|up_3|NZ_CP025046.1_2413313_2413631_+	NA	NA|155aa|up_2|NZ_CP025046.1_2413766_2414231_+	NA	NA|54aa|up_1|NZ_CP025046.1_2414559_2414721_-	NA	NA|51aa|up_0|NZ_CP025046.1_2415706_2415859_-	NA	NA|308aa|down_0|NZ_CP025046.1_2416997_2417921_-	pfam09851, SHOCT, Short C-terminal domain	NA|51aa|down_1|NZ_CP025046.1_2418114_2418267_-	NA	NA|108aa|down_2|NZ_CP025046.1_2418540_2418864_-	NA	NA|85aa|down_3|NZ_CP025046.1_2418899_2419154_-	NA	NA|126aa|down_4|NZ_CP025046.1_2420872_2421250_-	pfam03965, Penicillinase_R, Penicillinase repressor	NA|165aa|down_5|NZ_CP025046.1_2422054_2422549_+	TIGR01710, Type_II_secretion_system_protein_G, type II secretion system protein G	NA|57aa|down_6|NZ_CP025046.1_2422937_2423108_+	NA	NA|117aa|down_7|NZ_CP025046.1_2423935_2424286_+	pfam12676, DUF3796, Protein of unknown function (DUF3796)	NA|67aa|down_8|NZ_CP025046.1_2424287_2424488_+	COG1476, COG1476, Predicted transcriptional regulators [Transcription]	NA|59aa|down_9|NZ_CP025046.1_2424810_2424987_+	NA
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	8	2579702-2579859	5	PILER-CR	no	cas3,cas5,cas7,cas6	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Unclear	AGGTTTAAGATTAACTAAGTGG---------ATTTCA	37	0	0	NA	NA	NA	2	2	Unclear	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|492aa|down_3|NZ_CP025046.1_2584285_2585761_-,NA|59aa|down_5|NZ_CP025046.1_2586603_2586780_-	NA|448aa|up_9|NZ_CP025046.1_2572158_2573502_-	pfam06898, YqfD, Putative stage IV sporulation protein YqfD	NA|79aa|up_8|NZ_CP025046.1_2573514_2573751_-	pfam07873, YabP, YabP family	NA|188aa|up_7|NZ_CP025046.1_2573963_2574527_-	cd00552, RaiA, RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site	NA|166aa|up_6|NZ_CP025046.1_2574719_2575217_-	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family	NA|148aa|up_5|NZ_CP025046.1_2575327_2575771_-	pfam09424, YqeY, Yqey-like protein	NA|60aa|up_4|NZ_CP025046.1_2575800_2575980_-	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed	NA|117aa|up_3|NZ_CP025046.1_2576142_2576493_-	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides	NA|433aa|up_2|NZ_CP025046.1_2576535_2577834_-	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]	NA|253aa|up_1|NZ_CP025046.1_2577835_2578594_-	PRK11713, PRK11713, 16S ribosomal RNA methyltransferase RsmE; Provisional	NA|316aa|up_0|NZ_CP025046.1_2578612_2579560_-	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA)	cas3|803aa|down_0|NZ_CP025046.1_2580001_2582410_-	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3	cas5|266aa|down_1|NZ_CP025046.1_2582436_2583234_-	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5	cas7|339aa|down_2|NZ_CP025046.1_2583249_2584266_-	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7	NA|492aa|down_3|NZ_CP025046.1_2584285_2585761_-	NA	cas6|246aa|down_4|NZ_CP025046.1_2585765_2586503_-	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6	NA|59aa|down_5|NZ_CP025046.1_2586603_2586780_-	NA	NA|370aa|down_6|NZ_CP025046.1_2587213_2588323_+	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	NA|256aa|down_7|NZ_CP025046.1_2588352_2589120_+	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain	NA|458aa|down_8|NZ_CP025046.1_2589307_2590681_-	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily	NA|312aa|down_9|NZ_CP025046.1_2590716_2591652_-	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	9	2661606-2661963	6,7,5	PILER-CR,CRISPRCasFinder,CRT	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	GTTTTATATTAACTATATGGAATGTAAAT,ATTTACATTCCATATAGTTAATATAAAAC,ATTTACATTCCATATAGTTAATATAAAAC	29,29,29	0	0	NA	NA	I-A:I-A:I-A	4,5,5	5	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|53aa|down_0|NZ_CP025046.1_2662248_2662407_-	NA|240aa|up_9|NZ_CP025046.1_2649164_2649884_-	pfam01841, Transglut_core, Transglutaminase-like superfamily	NA|253aa|up_8|NZ_CP025046.1_2649930_2650689_-	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|451aa|up_7|NZ_CP025046.1_2650819_2652172_-	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases	NA|517aa|up_6|NZ_CP025046.1_2652268_2653819_-	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component	NA|272aa|up_5|NZ_CP025046.1_2653871_2654687_-	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional	NA|161aa|up_4|NZ_CP025046.1_2654707_2655190_-	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1	NA|127aa|up_3|NZ_CP025046.1_2655473_2655854_-	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase	NA|406aa|up_2|NZ_CP025046.1_2655948_2657166_-	PRK08198, PRK08198, threonine dehydratase; Provisional	NA|543aa|up_1|NZ_CP025046.1_2657824_2659453_+	TIGR03801, For_A_Pyridoxal-5-_Phosphate, aspartate 4-decarboxylase	NA|332aa|up_0|NZ_CP025046.1_2659573_2660569_+	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase	NA|53aa|down_0|NZ_CP025046.1_2662248_2662407_-	NA	NA|457aa|down_1|NZ_CP025046.1_2662765_2664136_-	NF033435, S-layer_Clost, S-layer protein SlpA	NA|91aa|down_2|NZ_CP025046.1_2665187_2665460_+	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons	NA|223aa|down_3|NZ_CP025046.1_2665777_2666446_-	pfam04892, VanZ, VanZ like family	NA|807aa|down_4|NZ_CP025046.1_2667281_2669702_-	PRK00390, leuS, leucyl-tRNA synthetase; Validated	NA|117aa|down_5|NZ_CP025046.1_2670055_2670406_-	pfam02410, RsfS, Ribosomal silencing factor during starvation	NA|191aa|down_6|NZ_CP025046.1_2670522_2671095_-	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]	NA|230aa|down_7|NZ_CP025046.1_2671095_2671785_-	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase	NA|213aa|down_8|NZ_CP025046.1_2672060_2672699_+	PRK00117, recX, recombination regulator RecX; Reviewed	NA|668aa|down_9|NZ_CP025046.1_2672851_2674855_+	PLN02447, PLN02447, 1,4-alpha-glucan-branching enzyme
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	10	2928741-2929066	8	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TTACCATCTATTTGTTGCCATCCTGT	26	0	0	NA	NA	NA	5	5	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|107aa|down_2|NZ_CP025046.1_2931929_2932250_-,NA|664aa|down_3|NZ_CP025046.1_2932239_2934231_-,NA|458aa|down_7|NZ_CP025046.1_2945017_2946391_-	NA|218aa|up_9|NZ_CP025046.1_2913742_2914396_-	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown]	NA|448aa|up_8|NZ_CP025046.1_2914898_2916242_+	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]	NA|455aa|up_7|NZ_CP025046.1_2916420_2917785_+	cd01298, ATZ_TRZ_like, TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases	NA|622aa|up_6|NZ_CP025046.1_2917962_2919828_-	smart00910, HIRAN, The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p	NA|406aa|up_5|NZ_CP025046.1_2920063_2921281_-	cd17396, MFS_YdiM_like, Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters	NA|288aa|up_4|NZ_CP025046.1_2921480_2922344_-	PRK12548, PRK12548, shikimate dehydrogenase	NA|641aa|up_3|NZ_CP025046.1_2922425_2924348_-	TIGR03997, NADH:flavin_oxidoreductase, mycofactocin system FadH/OYE family oxidoreductase 2	NA|283aa|up_2|NZ_CP025046.1_2924411_2925260_-	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]	NA|294aa|up_1|NZ_CP025046.1_2925672_2926554_+	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold	NA|288aa|up_0|NZ_CP025046.1_2926761_2927625_-	cd01027, TOPRIM_RNase_M5_like, TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea	NA|338aa|down_0|NZ_CP025046.1_2929825_2930839_-	PLN02240, PLN02240, UDP-glucose 4-epimerase	NA|290aa|down_1|NZ_CP025046.1_2930862_2931732_-	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]	NA|107aa|down_2|NZ_CP025046.1_2931929_2932250_-	NA	NA|664aa|down_3|NZ_CP025046.1_2932239_2934231_-	NA	NA|848aa|down_4|NZ_CP025046.1_2934353_2936897_-	PTZ00121, PTZ00121, MAEBL; Provisional	NA|226aa|down_5|NZ_CP025046.1_2937640_2938318_+	cd05826, Sortase_B, Sortase domain found in class B sortases	NA|313aa|down_6|NZ_CP025046.1_2943707_2944646_+	cd10948, CE4_BsPdaA_like, Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs	NA|458aa|down_7|NZ_CP025046.1_2945017_2946391_-	NA	NA|441aa|down_8|NZ_CP025046.1_2946577_2947900_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|235aa|down_9|NZ_CP025046.1_2947892_2948597_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	11	2983523-2983830	9	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TTTCTTTTACAGCTTCTAAACATAT	25	0	0	NA	NA	NA	4	4	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|222aa|down_0|NZ_CP025046.1_2985123_2985789_+	NA|205aa|up_9|NZ_CP025046.1_2971683_2972298_-	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain	NA|150aa|up_8|NZ_CP025046.1_2972312_2972762_-	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional	NA|736aa|up_7|NZ_CP025046.1_2972786_2974994_-	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]	NA|171aa|up_6|NZ_CP025046.1_2975067_2975580_-	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional	NA|817aa|up_5|NZ_CP025046.1_2975592_2978043_-	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ	NA|555aa|up_4|NZ_CP025046.1_2978055_2979720_-	COG0661, AarF, Predicted unusual protein kinase [General function prediction only]	NA|166aa|up_3|NZ_CP025046.1_2980017_2980515_-	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E	NA|460aa|up_2|NZ_CP025046.1_2980543_2981923_-	TIGR03974, six-Cys-in-45_modification_radical_SAM_protein, SCIFF radical SAM maturase	NA|49aa|up_1|NZ_CP025046.1_2982227_2982374_-	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|193aa|up_0|NZ_CP025046.1_2982403_2982982_-	pfam04647, AgrB, Accessory gene regulator B	NA|222aa|down_0|NZ_CP025046.1_2985123_2985789_+	NA	NA|901aa|down_1|NZ_CP025046.1_2986294_2988997_-	cd01948, EAL, EAL domain	NA|517aa|down_2|NZ_CP025046.1_2989022_2990573_-	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|571aa|down_3|NZ_CP025046.1_2990895_2992608_-	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]	NA|87aa|down_4|NZ_CP025046.1_2992961_2993222_-	pfam00381, PTS-HPr, PTS HPr component phosphorylation site	NA|404aa|down_5|NZ_CP025046.1_2993414_2994626_-	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|578aa|down_6|NZ_CP025046.1_2994857_2996591_-	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX	NA|133aa|down_7|NZ_CP025046.1_2996630_2997029_-	COG1959, COG1959, Predicted transcriptional regulator [Transcription]	NA|516aa|down_8|NZ_CP025046.1_2997031_2998579_-	cd01948, EAL, EAL domain	NA|302aa|down_9|NZ_CP025046.1_2998893_2999799_-	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	12	2983937-2984226	10	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TTTCTTTTACAGCTTCTAAACATAT	25	0	0	NA	NA	NA	4	4	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|222aa|down_0|NZ_CP025046.1_2985123_2985789_+	NA|205aa|up_9|NZ_CP025046.1_2971683_2972298_-	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain	NA|150aa|up_8|NZ_CP025046.1_2972312_2972762_-	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional	NA|736aa|up_7|NZ_CP025046.1_2972786_2974994_-	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]	NA|171aa|up_6|NZ_CP025046.1_2975067_2975580_-	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional	NA|817aa|up_5|NZ_CP025046.1_2975592_2978043_-	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ	NA|555aa|up_4|NZ_CP025046.1_2978055_2979720_-	COG0661, AarF, Predicted unusual protein kinase [General function prediction only]	NA|166aa|up_3|NZ_CP025046.1_2980017_2980515_-	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E	NA|460aa|up_2|NZ_CP025046.1_2980543_2981923_-	TIGR03974, six-Cys-in-45_modification_radical_SAM_protein, SCIFF radical SAM maturase	NA|49aa|up_1|NZ_CP025046.1_2982227_2982374_-	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|193aa|up_0|NZ_CP025046.1_2982403_2982982_-	pfam04647, AgrB, Accessory gene regulator B	NA|222aa|down_0|NZ_CP025046.1_2985123_2985789_+	NA	NA|901aa|down_1|NZ_CP025046.1_2986294_2988997_-	cd01948, EAL, EAL domain	NA|517aa|down_2|NZ_CP025046.1_2989022_2990573_-	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|571aa|down_3|NZ_CP025046.1_2990895_2992608_-	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]	NA|87aa|down_4|NZ_CP025046.1_2992961_2993222_-	pfam00381, PTS-HPr, PTS HPr component phosphorylation site	NA|404aa|down_5|NZ_CP025046.1_2993414_2994626_-	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|578aa|down_6|NZ_CP025046.1_2994857_2996591_-	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX	NA|133aa|down_7|NZ_CP025046.1_2996630_2997029_-	COG1959, COG1959, Predicted transcriptional regulator [Transcription]	NA|516aa|down_8|NZ_CP025046.1_2997031_2998579_-	cd01948, EAL, EAL domain	NA|302aa|down_9|NZ_CP025046.1_2998893_2999799_-	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	13	2984429-2984519	11	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TTTCTTTTACAGCTTCTAAACATAT	25	0	0	NA	NA	NA	1	1	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA,NA|222aa|down_0|NZ_CP025046.1_2985123_2985789_+	NA|205aa|up_9|NZ_CP025046.1_2971683_2972298_-	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain	NA|150aa|up_8|NZ_CP025046.1_2972312_2972762_-	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional	NA|736aa|up_7|NZ_CP025046.1_2972786_2974994_-	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]	NA|171aa|up_6|NZ_CP025046.1_2975067_2975580_-	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional	NA|817aa|up_5|NZ_CP025046.1_2975592_2978043_-	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ	NA|555aa|up_4|NZ_CP025046.1_2978055_2979720_-	COG0661, AarF, Predicted unusual protein kinase [General function prediction only]	NA|166aa|up_3|NZ_CP025046.1_2980017_2980515_-	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E	NA|460aa|up_2|NZ_CP025046.1_2980543_2981923_-	TIGR03974, six-Cys-in-45_modification_radical_SAM_protein, SCIFF radical SAM maturase	NA|49aa|up_1|NZ_CP025046.1_2982227_2982374_-	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|193aa|up_0|NZ_CP025046.1_2982403_2982982_-	pfam04647, AgrB, Accessory gene regulator B	NA|222aa|down_0|NZ_CP025046.1_2985123_2985789_+	NA	NA|901aa|down_1|NZ_CP025046.1_2986294_2988997_-	cd01948, EAL, EAL domain	NA|517aa|down_2|NZ_CP025046.1_2989022_2990573_-	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|571aa|down_3|NZ_CP025046.1_2990895_2992608_-	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]	NA|87aa|down_4|NZ_CP025046.1_2992961_2993222_-	pfam00381, PTS-HPr, PTS HPr component phosphorylation site	NA|404aa|down_5|NZ_CP025046.1_2993414_2994626_-	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|578aa|down_6|NZ_CP025046.1_2994857_2996591_-	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX	NA|133aa|down_7|NZ_CP025046.1_2996630_2997029_-	COG1959, COG1959, Predicted transcriptional regulator [Transcription]	NA|516aa|down_8|NZ_CP025046.1_2997031_2998579_-	cd01948, EAL, EAL domain	NA|302aa|down_9|NZ_CP025046.1_2998893_2999799_-	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	14	3196004-3197666	12,6,7	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,WYL	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Unclear	ATTTACATACCACTTAGTTAATATAAAAC,ATTTACATACCACTTAGTTAATATAAAAC,GTTTTATATTAACTAAGTGGTATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	25,25,22	25	Unclear	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA|67aa|up_7|NZ_CP025046.1_3188897_3189098_+,NA|260aa|up_1|NZ_CP025046.1_3194280_3195060_+,NA	NA|740aa|up_9|NZ_CP025046.1_3183244_3185464_-	cd01948, EAL, EAL domain	NA|885aa|up_8|NZ_CP025046.1_3185739_3188394_-	PRK13805, PRK13805, bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional	NA|67aa|up_7|NZ_CP025046.1_3188897_3189098_+	NA	NA|197aa|up_6|NZ_CP025046.1_3189304_3189895_-	PRK08305, spoVFB, dipicolinate synthase subunit B; Reviewed	NA|292aa|up_5|NZ_CP025046.1_3189897_3190773_-	PRK08306, PRK08306, dipicolinate synthase subunit DpsA	NA|464aa|up_4|NZ_CP025046.1_3190848_3192240_-	cd17633, AFD_YhfT-like, fatty acid-CoA ligase VraA	NA|379aa|up_3|NZ_CP025046.1_3192243_3193380_-	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine	NA|182aa|up_2|NZ_CP025046.1_3193411_3193957_-	pfam02632, BioY, BioY family	NA|260aa|up_1|NZ_CP025046.1_3194280_3195060_+	NA	NA|143aa|up_0|NZ_CP025046.1_3195514_3195943_-	PRK10562, PRK10562, putative acetyltransferase; Provisional	cas2|89aa|down_0|NZ_CP025046.1_3197849_3198116_-	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2	cas1|327aa|down_1|NZ_CP025046.1_3198118_3199099_-	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP	cas4|184aa|down_2|NZ_CP025046.1_3199101_3199653_-	pfam01930, Cas_Cas4, Domain of unknown function DUF83	cas3|774aa|down_3|NZ_CP025046.1_3199667_3201989_-	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3	cas5|234aa|down_4|NZ_CP025046.1_3201999_3202701_-	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5	cas7|305aa|down_5|NZ_CP025046.1_3202702_3203617_-	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7	cas8b2|617aa|down_6|NZ_CP025046.1_3203618_3205469_-	pfam09706, Cas_CXXC_CXXC, CRISPR-associated protein (Cas_CXXC_CXXC)	cas6|246aa|down_7|NZ_CP025046.1_3205474_3206212_-	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6	WYL|306aa|down_8|NZ_CP025046.1_3206289_3207207_-	pfam13280, WYL, WYL domain	NA|639aa|down_9|NZ_CP025046.1_3207485_3209402_-	pfam02687, FtsX, FtsX-like permease family
GCF_002812625.1_ASM281262v1	NZ_CP025046	Clostridioides difficile strain W0022a chromosome, complete genome	15	4130515-4130604	13	CRISPRCasFinder	no		cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	Orphan	TGTGCGTTAGCACTTTAAGCAACAGAAT	28	1	5	4130543-4130576|4130543-4130576|4130543-4130576|4130543-4130576|4130543-4130576	NZ_CP025046.1_41193-41226|NZ_CP025046.1_48205-48238|NZ_CP025046.1_64268-64301|NZ_CP025046.1_2941749-2941716|NZ_CP025046.1_4116090-4116123	NA	1	1	Orphan	cas14k,csa3,WYL,cas3,DEDDh,cas14j,DinG,RT,cas5,cas7,cas6,cas2,cas1,cas4,cas8b2	NA|74aa|up_1|NZ_CP025046.1_4126800_4127022_+,NA|138aa|down_0|NZ_CP025046.1_4137856_4138270_+	NA|258aa|up_9|NZ_CP025046.1_4108118_4108892_+	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily	NA|170aa|up_8|NZ_CP025046.1_4119622_4120132_+	COG1827, COG1827, Predicted small molecule binding protein (contains 3H domain) [General function prediction only]	NA|294aa|up_7|NZ_CP025046.1_4120143_4121025_+	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS	NA|424aa|up_6|NZ_CP025046.1_4121483_4122755_+	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional	NA|152aa|up_5|NZ_CP025046.1_4123075_4123531_+	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|546aa|up_4|NZ_CP025046.1_4124001_4125639_+	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated	NA|117aa|up_3|NZ_CP025046.1_4125697_4126048_+	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein	NA|200aa|up_2|NZ_CP025046.1_4126060_4126660_+	PRK00076, recR, recombination protein RecR; Reviewed	NA|74aa|up_1|NZ_CP025046.1_4126800_4127022_+	NA	NA|402aa|up_0|NZ_CP025046.1_4127092_4128298_-	cd17507, GT28_Beta-DGS-like, beta-diglucosyldiacylglycerol synthase and similar proteins	NA|138aa|down_0|NZ_CP025046.1_4137856_4138270_+	NA	NA|1144aa|down_1|NZ_CP025046.1_4138578_4142010_+	PRK12999, PRK12999, pyruvate carboxylase; Reviewed	NA|643aa|down_2|NZ_CP025046.1_4142251_4144180_+	PRK12740, PRK12740, elongation factor G-like protein EF-G2	NA|155aa|down_3|NZ_CP025046.1_4144632_4145097_+	COG4463, CtsR, Transcriptional repressor of class III stress genes [Transcription]	NA|165aa|down_4|NZ_CP025046.1_4145103_4145598_+	COG3880, COG3880, Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]	NA|342aa|down_5|NZ_CP025046.1_4145613_4146639_+	PRK01059, PRK01059, ATP:guanido phosphotransferase; Provisional	NA|816aa|down_6|NZ_CP025046.1_4146625_4149073_+	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]	NA|458aa|down_7|NZ_CP025046.1_4149252_4150626_+	PRK11823, PRK11823, DNA repair protein RadA; Provisional	NA|357aa|down_8|NZ_CP025046.1_4150628_4151699_+	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional	NA|365aa|down_9|NZ_CP025046.1_4151787_4152882_+	COG4956, COG4956, Integral membrane protein (PIN domain superfamily) [General function prediction only]
