assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	1	333630-334428	1	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGGNGCCGCCGGNN	18	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_0|NZ_CP023626.1_333145_333328_-,NA	NA|398aa|up_9|NZ_CP023626.1_323323_324517_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023626.1_324552_326235_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023626.1_326251_328447_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023626.1_328560_329694_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023626.1_329690_330311_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023626.1_330407_330989_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023626.1_330918_331644_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023626.1_331733_332654_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023626.1_332693_333122_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023626.1_333145_333328_-	NA	NA|836aa|down_0|NZ_CP023626.1_336528_339036_-	pfam00934, PE, PE family	NA|537aa|down_1|NZ_CP023626.1_339326_340937_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_2|NZ_CP023626.1_340960_341869_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_3|NZ_CP023626.1_342092_343988_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_4|NZ_CP023626.1_343984_345601_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_5|NZ_CP023626.1_345597_349590_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_6|NZ_CP023626.1_349586_349895_+	pfam00934, PE, PE family	NA|514aa|down_7|NZ_CP023626.1_349897_351439_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_8|NZ_CP023626.1_351487_351781_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_9|NZ_CP023626.1_351810_352101_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	2	338067-338289	1	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	ATCCGCCGCTACCGCCGGTGCCGCCGGCGCCGAACAGCCCGCC	43	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_1|NZ_CP023626.1_333145_333328_-,NA	NA|561aa|up_9|NZ_CP023626.1_324552_326235_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_8|NZ_CP023626.1_326251_328447_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_7|NZ_CP023626.1_328560_329694_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_6|NZ_CP023626.1_329690_330311_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_5|NZ_CP023626.1_330407_330989_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_4|NZ_CP023626.1_330918_331644_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_3|NZ_CP023626.1_331733_332654_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_2|NZ_CP023626.1_332693_333122_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_1|NZ_CP023626.1_333145_333328_-	NA	NA|615aa|up_0|NZ_CP023626.1_333422_335267_-	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional	NA|537aa|down_0|NZ_CP023626.1_339326_340937_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_1|NZ_CP023626.1_340960_341869_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_2|NZ_CP023626.1_342092_343988_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_3|NZ_CP023626.1_343984_345601_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_4|NZ_CP023626.1_345597_349590_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_5|NZ_CP023626.1_349586_349895_+	pfam00934, PE, PE family	NA|514aa|down_6|NZ_CP023626.1_349897_351439_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_7|NZ_CP023626.1_351487_351781_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_8|NZ_CP023626.1_351810_352101_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]	NA|296aa|down_9|NZ_CP023626.1_352111_352999_+	pfam14011, ESX-1_EspG, EspG family
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	3	366426-367124	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366714-366755|366789-366821	NZ_CP023626.1_374730-374771|NZ_CP023626.1_373545-373577	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|101aa|up_4|NZ_CP023626.1_363438_363741_+,NA|161aa|down_1|NZ_CP023626.1_376519_377002_-,NA|410aa|down_5|NZ_CP023626.1_379118_380348_+	NA|262aa|up_9|NZ_CP023626.1_358133_358919_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023626.1_358907_359711_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023626.1_359720_361118_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023626.1_361296_363072_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023626.1_363214_363442_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023626.1_363438_363741_+	NA	NA|74aa|up_3|NZ_CP023626.1_363788_364010_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023626.1_364006_364432_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023626.1_364567_365200_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023626.1_365196_366105_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023626.1_375860_376532_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023626.1_376519_377002_-	NA	NA|239aa|down_2|NZ_CP023626.1_377059_377776_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023626.1_377877_378534_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023626.1_378603_379095_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023626.1_379118_380348_+	NA	NA|621aa|down_6|NZ_CP023626.1_380502_382365_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023626.1_382436_382823_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023626.1_382825_383488_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023626.1_383548_384433_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	4	691944-692020	2	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|136aa|up_9|NZ_CP023626.1_677839_678247_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_8|NZ_CP023626.1_678306_678993_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_7|NZ_CP023626.1_679146_681780_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_6|NZ_CP023626.1_681802_684190_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_5|NZ_CP023626.1_684327_685050_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_4|NZ_CP023626.1_685046_685844_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_3|NZ_CP023626.1_685845_686733_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_2|NZ_CP023626.1_686738_687953_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|344aa|up_1|NZ_CP023626.1_687949_688981_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|482aa|up_0|NZ_CP023626.1_688977_690423_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023626.1_693155_694706_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023626.1_694757_695150_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023626.1_695146_695404_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023626.1_695586_696822_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023626.1_697072_697486_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023626.1_697482_697719_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023626.1_697822_698329_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023626.1_698442_698913_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023626.1_698956_699718_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023626.1_699774_700086_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	5	926506-927453	2	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927289-927324|927289-927324|927289-927324	NZ_CP023626.1_675046-675011|NZ_CP023626.1_1213602-1213637|NZ_CP023626.1_2423539-2423504	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|184aa|down_2|NZ_CP023626.1_931463_932015_-,NA|81aa|down_8|NZ_CP023626.1_937478_937721_+	NA|685aa|up_9|NZ_CP023626.1_914145_916200_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|389aa|up_8|NZ_CP023626.1_916365_917532_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023626.1_917619_918636_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023626.1_918797_919439_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023626.1_919519_920575_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023626.1_920626_921019_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023626.1_921076_921499_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023626.1_921460_921751_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023626.1_921855_922761_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023626.1_922779_923595_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|883aa|down_0|NZ_CP023626.1_927722_930371_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023626.1_930838_931483_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023626.1_931463_932015_-	NA	NA|241aa|down_3|NZ_CP023626.1_932095_932818_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023626.1_932888_933917_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023626.1_934605_935376_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023626.1_935462_936275_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023626.1_936342_937203_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023626.1_937478_937721_+	NA	NA|431aa|down_9|NZ_CP023626.1_937997_939290_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	6	1191209-1191274	3	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	1	9	1191234-1191249|1191234-1191249|1191234-1191249|1191234-1191249|1191234-1191249|1191234-1191249|1191234-1191249|1191234-1191249|1191234-1191249	NZ_CP023626.1_305024-305009|NZ_CP023626.1_337812-337827|NZ_CP023626.1_1188760-1188775|NZ_CP023626.1_1618240-1618255|NZ_CP023626.1_2356854-2356869|NZ_CP023626.1_3163210-3163195|NZ_CP023626.1_3739438-3739453|NZ_CP023626.1_3933303-3933288|NZ_CP023626.1_3933906-3933891	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|544aa|up_9|NZ_CP023626.1_1180576_1182208_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023626.1_1182283_1183348_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023626.1_1183400_1183874_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023626.1_1183907_1184771_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023626.1_1184775_1185633_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023626.1_1185633_1186716_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023626.1_1186796_1187216_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023626.1_1187327_1187894_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023626.1_1187890_1188286_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023626.1_1188313_1190317_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023626.1_1192398_1194162_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023626.1_1194158_1194932_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023626.1_1194943_1195981_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023626.1_1196167_1197004_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023626.1_1197119_1197971_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023626.1_1198044_1199262_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023626.1_1199314_1200259_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023626.1_1200481_1201549_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023626.1_1201605_1203000_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023626.1_1203201_1203924_+	pfam06271, RDD, RDD family
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	7	1572004-1573076	4	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	1	1	1572204-1572225	NZ_CP023626.1_1211952-1211931	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|106aa|up_7|NZ_CP023626.1_1563768_1564086_+,NA	NA|103aa|up_9|NZ_CP023626.1_1561283_1561592_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023626.1_1561588_1563208_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023626.1_1563768_1564086_+	NA	NA|209aa|up_6|NZ_CP023626.1_1564219_1564846_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023626.1_1564911_1565244_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023626.1_1565259_1566516_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023626.1_1566643_1567855_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023626.1_1567927_1569406_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023626.1_1569402_1570788_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023626.1_1570865_1571900_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023626.1_1573930_1574332_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023626.1_1574328_1574586_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023626.1_1574668_1575628_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023626.1_1575652_1576615_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023626.1_1576748_1577351_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023626.1_1577431_1579399_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023626.1_1579416_1580241_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023626.1_1580409_1580892_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023626.1_1580963_1581788_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023626.1_1581984_1582923_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	8	2088035-2088289	3	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCNCCGTCGCCGCCNNTGCC	21	2	3	2088116-2088133|2088116-2088133|2088206-2088223	NZ_CP023626.1_401026-401009|NZ_CP023626.1_607362-607345|NZ_CP023626.1_3449924-3449907	NA	5	5	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|88aa|up_0|NZ_CP023626.1_2087394_2087658_-,NA	NA|165aa|up_9|NZ_CP023626.1_2073688_2074183_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023626.1_2074586_2075264_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023626.1_2075622_2078448_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023626.1_2078674_2079535_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023626.1_2079575_2080442_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023626.1_2080446_2082333_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023626.1_2082348_2084382_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023626.1_2084501_2086727_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023626.1_2087002_2087398_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023626.1_2087394_2087658_-	NA	NA|346aa|down_0|NZ_CP023626.1_2089426_2090464_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023626.1_2090463_2091831_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023626.1_2092004_2093441_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023626.1_2093476_2094928_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023626.1_2094957_2095908_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023626.1_2095922_2096339_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023626.1_2096616_2097039_+	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria	NA|101aa|down_7|NZ_CP023626.1_2097087_2097390_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023626.1_2097386_2097701_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023626.1_2097700_2099434_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	9	2163114-2163218	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CAACCCAAACGGATTAATCGCGAAACCAGGGATCGT	36	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|157aa|up_9|NZ_CP023626.1_2152175_2152646_-,NA|136aa|up_1|NZ_CP023626.1_2159657_2160065_-,NA|127aa|down_6|NZ_CP023626.1_2176287_2176668_-	NA|157aa|up_9|NZ_CP023626.1_2152175_2152646_-	NA	NA|155aa|up_8|NZ_CP023626.1_2152985_2153450_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_7|NZ_CP023626.1_2153625_2155848_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_6|NZ_CP023626.1_2155885_2156329_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_5|NZ_CP023626.1_2156442_2157036_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_4|NZ_CP023626.1_2157118_2157724_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_3|NZ_CP023626.1_2157823_2158828_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_2|NZ_CP023626.1_2158927_2159680_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_1|NZ_CP023626.1_2159657_2160065_-	NA	NA|767aa|up_0|NZ_CP023626.1_2160199_2162500_+	PLN02892, PLN02892, isocitrate lyase	NA|988aa|down_0|NZ_CP023626.1_2167386_2170350_-	pfam00823, PPE, PPE family	NA|155aa|down_1|NZ_CP023626.1_2170798_2171263_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_2|NZ_CP023626.1_2171360_2172224_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_3|NZ_CP023626.1_2172261_2173533_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_4|NZ_CP023626.1_2173804_2174920_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_5|NZ_CP023626.1_2174910_2176251_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_6|NZ_CP023626.1_2176287_2176668_-	NA	NA|621aa|down_7|NZ_CP023626.1_2176824_2178687_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_8|NZ_CP023626.1_2178694_2179174_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_9|NZ_CP023626.1_2179410_2180184_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	10	2168552-2168771	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_2|NZ_CP023626.1_2159657_2160065_-,NA|127aa|down_5|NZ_CP023626.1_2176287_2176668_-	NA|155aa|up_9|NZ_CP023626.1_2152985_2153450_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_8|NZ_CP023626.1_2153625_2155848_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_7|NZ_CP023626.1_2155885_2156329_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_6|NZ_CP023626.1_2156442_2157036_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_5|NZ_CP023626.1_2157118_2157724_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_4|NZ_CP023626.1_2157823_2158828_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_3|NZ_CP023626.1_2158927_2159680_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_2|NZ_CP023626.1_2159657_2160065_-	NA	NA|767aa|up_1|NZ_CP023626.1_2160199_2162500_+	PLN02892, PLN02892, isocitrate lyase	NA|1460aa|up_0|NZ_CP023626.1_2162669_2167049_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023626.1_2170798_2171263_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023626.1_2171360_2172224_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023626.1_2172261_2173533_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023626.1_2173804_2174920_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023626.1_2174910_2176251_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023626.1_2176287_2176668_-	NA	NA|621aa|down_6|NZ_CP023626.1_2176824_2178687_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023626.1_2178694_2179174_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023626.1_2179410_2180184_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023626.1_2180187_2180955_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	11	3118899-3120253	2,7,4	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-C,Type III-A,Type III-B,Type III-D	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-C,TypeIII-A,TypeIII-B,TypeIII-D	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_8|NZ_CP023626.1_3112178_3112433_-,NA|135aa|up_7|NZ_CP023626.1_3112580_3112985_+,NA|64aa|up_6|NZ_CP023626.1_3112981_3113173_+,NA|86aa|up_4|NZ_CP023626.1_3114759_3115017_+,NA|104aa|up_3|NZ_CP023626.1_3115121_3115433_+,NA|203aa|up_2|NZ_CP023626.1_3115852_3116461_+,NA	NA|92aa|up_9|NZ_CP023626.1_3111727_3112003_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023626.1_3112178_3112433_-	NA	NA|135aa|up_7|NZ_CP023626.1_3112580_3112985_+	NA	NA|64aa|up_6|NZ_CP023626.1_3112981_3113173_+	NA	NA|385aa|up_5|NZ_CP023626.1_3113371_3114526_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023626.1_3114759_3115017_+	NA	NA|104aa|up_3|NZ_CP023626.1_3115121_3115433_+	NA	NA|203aa|up_2|NZ_CP023626.1_3115852_3116461_+	NA	NA|470aa|up_1|NZ_CP023626.1_3116531_3117941_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023626.1_3117937_3118750_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023626.1_3120279_3121541_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023626.1_3123338_3123680_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023626.1_3123680_3124697_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023626.1_3124709_3125858_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023626.1_3125953_3127081_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023626.1_3127077_3127986_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023626.1_3127966_3128677_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023626.1_3128686_3129061_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023626.1_3129057_3131496_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023626.1_3131492_3132215_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	12	3121576-3123290	8,5,3,4	CRISPRCasFinder,CRT,PILER-CR,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-C,Type III-A,Type III-B,Type III-D	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A:II-B,III-A	23,23,20,20	23	TypeIII-C,TypeIII-A,TypeIII-B,TypeIII-D	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_9|NZ_CP023626.1_3112178_3112433_-,NA|135aa|up_8|NZ_CP023626.1_3112580_3112985_+,NA|64aa|up_7|NZ_CP023626.1_3112981_3113173_+,NA|86aa|up_5|NZ_CP023626.1_3114759_3115017_+,NA|104aa|up_4|NZ_CP023626.1_3115121_3115433_+,NA|203aa|up_3|NZ_CP023626.1_3115852_3116461_+,NA	NA|85aa|up_9|NZ_CP023626.1_3112178_3112433_-	NA	NA|135aa|up_8|NZ_CP023626.1_3112580_3112985_+	NA	NA|64aa|up_7|NZ_CP023626.1_3112981_3113173_+	NA	NA|385aa|up_6|NZ_CP023626.1_3113371_3114526_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023626.1_3114759_3115017_+	NA	NA|104aa|up_4|NZ_CP023626.1_3115121_3115433_+	NA	NA|203aa|up_3|NZ_CP023626.1_3115852_3116461_+	NA	NA|470aa|up_2|NZ_CP023626.1_3116531_3117941_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023626.1_3117937_3118750_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023626.1_3120279_3121541_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023626.1_3123338_3123680_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023626.1_3123680_3124697_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023626.1_3124709_3125858_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023626.1_3125953_3127081_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023626.1_3127077_3127986_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023626.1_3127966_3128677_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023626.1_3128686_3129061_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023626.1_3129057_3131496_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023626.1_3131492_3132215_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023626.1_3132614_3133160_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	13	3740358-3740899	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|96aa|down_4|NZ_CP023626.1_3755001_3755289_-,NA|87aa|down_8|NZ_CP023626.1_3768408_3768669_-	NA|282aa|up_9|NZ_CP023626.1_3719646_3720492_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023626.1_3720966_3721407_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023626.1_3721440_3722310_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023626.1_3722330_3723341_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023626.1_3723625_3724258_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023626.1_3724324_3725554_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023626.1_3725836_3727186_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023626.1_3727197_3728337_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023626.1_3728333_3729065_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023626.1_3729073_3736645_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023626.1_3742871_3743129_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023626.1_3743384_3752858_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023626.1_3753483_3753930_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023626.1_3753966_3754707_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023626.1_3755001_3755289_-	NA	NA|265aa|down_5|NZ_CP023626.1_3767018_3767813_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_6|NZ_CP023626.1_3767894_3768266_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_7|NZ_CP023626.1_3768163_3768382_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_8|NZ_CP023626.1_3768408_3768669_-	NA	NA|130aa|down_9|NZ_CP023626.1_3768783_3769173_+	pfam05305, DUF732, Protein of unknown function (DUF732)
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	14	3947687-3949664	7	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CNNCGGCGGNNCCGGCGGCNNCGGCGGC	28	4	10	3947715-3947773|3947715-3947773|3947715-3947773|3947802-3947881|3947802-3947881|3947910-3947992|3947910-3947992|3948576-3948619|3948576-3948619|3948576-3948619	NZ_CP023626.1_3946773-3946831|NZ_CP023626.1_3947124-3947182|NZ_CP023626.1_3947475-3947533|NZ_CP023626.1_3946860-3946939|NZ_CP023626.1_3947211-3947290|NZ_CP023626.1_3946968-3947050|NZ_CP023626.1_3946626-3946708|NZ_CP023626.1_3946692-3946735|NZ_CP023626.1_3947034-3947077|NZ_CP023626.1_3947625-3947668	NA	23	23	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|280aa|down_2|NZ_CP023626.1_3953059_3953899_+	NA|318aa|up_9|NZ_CP023626.1_3920738_3921692_-	PRK07792, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional	NA|64aa|up_8|NZ_CP023626.1_3921716_3921908_-	COG1141, Fer, Ferredoxin [Energy production and conversion]	NA|401aa|up_7|NZ_CP023626.1_3922122_3923325_+	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|374aa|up_6|NZ_CP023626.1_3923349_3924471_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|503aa|up_5|NZ_CP023626.1_3924541_3926050_+	PRK07867, PRK07867, acyl-CoA synthetase; Validated	NA|1385aa|up_4|NZ_CP023626.1_3926220_3930375_+	pfam00934, PE, PE family	NA|1902aa|up_3|NZ_CP023626.1_3930665_3936371_+	pfam00934, PE, PE family	NA|516aa|up_2|NZ_CP023626.1_3936537_3938085_-	PRK07586, PRK07586, acetolactate synthase large subunit	NA|279aa|up_1|NZ_CP023626.1_3938081_3938918_-	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]	NA|219aa|up_0|NZ_CP023626.1_3944720_3945377_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|549aa|down_0|NZ_CP023626.1_3950452_3952099_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|264aa|down_1|NZ_CP023626.1_3952172_3952964_+	PRK07799, PRK07799, crotonase/enoyl-CoA hydratase family protein	NA|280aa|down_2|NZ_CP023626.1_3953059_3953899_+	NA	NA|399aa|down_3|NZ_CP023626.1_3953953_3955150_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|237aa|down_4|NZ_CP023626.1_3955178_3955889_+	pfam06314, ADC, Acetoacetate decarboxylase (ADC)	NA|348aa|down_5|NZ_CP023626.1_3955953_3956997_-	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family	NA|304aa|down_6|NZ_CP023626.1_3957149_3958061_+	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]	NA|355aa|down_7|NZ_CP023626.1_3958076_3959141_+	PRK07937, PRK07937, lipid-transfer protein; Provisional	NA|395aa|down_8|NZ_CP023626.1_3959157_3960342_+	PRK08313, PRK08313, thiolase domain-containing protein	NA|344aa|down_9|NZ_CP023626.1_3960383_3961415_+	cd14952, NHL_PKND_like, NHL repeat domain of the protein kinase PknD
GCF_002447935.1_ASM244793v1	NZ_CP023626	Mycobacterium tuberculosis strain MDRMA1565 chromosome, complete genome	15	4110305-4110393	9	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|257aa|up_8|NZ_CP023626.1_4100891_4101662_-,NA|119aa|up_3|NZ_CP023626.1_4106796_4107153_+,NA|52aa|up_2|NZ_CP023626.1_4107252_4107408_+,NA|233aa|up_0|NZ_CP023626.1_4109409_4110108_-,NA|126aa|down_6|NZ_CP023626.1_4115628_4116006_+	NA|288aa|up_9|NZ_CP023626.1_4099273_4100137_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023626.1_4100891_4101662_-	NA	NA|549aa|up_7|NZ_CP023626.1_4101658_4103305_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023626.1_4103301_4104165_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023626.1_4104157_4105084_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023626.1_4105085_4106711_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023626.1_4106796_4107153_+	NA	NA|52aa|up_2|NZ_CP023626.1_4107252_4107408_+	NA	NA|652aa|up_1|NZ_CP023626.1_4107418_4109374_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023626.1_4109409_4110108_-	NA	NA|173aa|down_0|NZ_CP023626.1_4110453_4110972_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023626.1_4110972_4111956_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023626.1_4111948_4113142_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023626.1_4113147_4113969_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023626.1_4114100_4114784_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023626.1_4114783_4115521_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023626.1_4115628_4116006_+	NA	NA|225aa|down_7|NZ_CP023626.1_4116104_4116779_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023626.1_4116884_4117679_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023626.1_4117685_4118141_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
