assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	1	366433-367131	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366721-366762|366796-366828	NZ_CP023623.1_374752-374793|NZ_CP023623.1_373567-373599	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|101aa|up_4|NZ_CP023623.1_363445_363748_+,NA|161aa|down_1|NZ_CP023623.1_376541_377024_-,NA|410aa|down_5|NZ_CP023623.1_379140_380370_+	NA|262aa|up_9|NZ_CP023623.1_358140_358926_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023623.1_358914_359718_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023623.1_359727_361125_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023623.1_361303_363079_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023623.1_363221_363449_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023623.1_363445_363748_+	NA	NA|74aa|up_3|NZ_CP023623.1_363795_364017_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023623.1_364013_364439_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023623.1_364574_365207_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023623.1_365203_366112_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023623.1_375882_376554_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023623.1_376541_377024_-	NA	NA|239aa|down_2|NZ_CP023623.1_377081_377798_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023623.1_377899_378556_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023623.1_378625_379117_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023623.1_379140_380370_+	NA	NA|621aa|down_6|NZ_CP023623.1_380524_382387_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023623.1_382458_382845_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023623.1_382847_383510_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023623.1_383570_384455_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	2	691978-692054	2	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|136aa|up_9|NZ_CP023623.1_677873_678281_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_8|NZ_CP023623.1_678340_679027_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_7|NZ_CP023623.1_679180_681814_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_6|NZ_CP023623.1_681836_684224_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_5|NZ_CP023623.1_684361_685084_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_4|NZ_CP023623.1_685080_685878_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_3|NZ_CP023623.1_685879_686767_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_2|NZ_CP023623.1_686772_687987_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_1|NZ_CP023623.1_689010_690456_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|479aa|up_0|NZ_CP023623.1_690452_691889_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023623.1_693189_694740_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023623.1_694791_695184_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023623.1_695180_695438_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023623.1_695620_696856_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023623.1_697106_697520_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023623.1_697516_697753_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023623.1_697856_698363_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023623.1_698476_698947_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023623.1_698990_699752_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023623.1_699808_700120_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	3	926564-927511	1	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927347-927382|927347-927382|927347-927382	NZ_CP023623.1_675075-675040|NZ_CP023623.1_1213663-1213698|NZ_CP023623.1_2423704-2423669	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|184aa|down_2|NZ_CP023623.1_931512_932064_-,NA|81aa|down_8|NZ_CP023623.1_937527_937770_+	NA|685aa|up_9|NZ_CP023623.1_914200_916255_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023623.1_916420_917590_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023623.1_917677_918694_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023623.1_918855_919497_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023623.1_919577_920633_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023623.1_920684_921077_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023623.1_921134_921557_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023623.1_921518_921809_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023623.1_921913_922819_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023623.1_922837_923653_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|880aa|down_0|NZ_CP023623.1_927780_930420_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023623.1_930887_931532_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023623.1_931512_932064_-	NA	NA|218aa|down_3|NZ_CP023623.1_932213_932867_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023623.1_932937_933966_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023623.1_934654_935425_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023623.1_935511_936324_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023623.1_936391_937252_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023623.1_937527_937770_+	NA	NA|431aa|down_9|NZ_CP023623.1_938046_939339_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	4	1191266-1191374	3	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|544aa|up_9|NZ_CP023623.1_1180633_1182265_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023623.1_1182340_1183405_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023623.1_1183457_1183931_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023623.1_1183964_1184828_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023623.1_1184832_1185690_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023623.1_1185690_1186773_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023623.1_1186853_1187273_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023623.1_1187384_1187951_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023623.1_1187947_1188343_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023623.1_1188370_1190374_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023623.1_1192459_1194223_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023623.1_1194219_1194993_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023623.1_1195004_1196042_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023623.1_1196228_1197065_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023623.1_1197180_1198032_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023623.1_1198105_1199323_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023623.1_1199375_1200320_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023623.1_1200542_1201610_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023623.1_1201666_1203061_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023623.1_1203262_1203985_+	pfam06271, RDD, RDD family
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	5	1211900-1212765	4	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GGCGGTGTCGGCGGTGCCGGCGG	23	4	8	1212283-1212304|1212328-1212343|1212466-1212487|1212466-1212487|1212721-1212742|1212721-1212742|1212721-1212742|1212721-1212742	NZ_CP023623.1_2960450-2960429|NZ_CP023623.1_2088554-2088539|NZ_CP023623.1_837388-837409|NZ_CP023623.1_1217558-1217579|NZ_CP023623.1_623822-623843|NZ_CP023623.1_37042-37021|NZ_CP023623.1_132080-132101|NZ_CP023623.1_2922201-2922222	NA	16	16	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|89aa|up_3|NZ_CP023623.1_1207332_1207599_+,NA|61aa|down_3|NZ_CP023623.1_1215138_1215321_+,NA|35aa|down_4|NZ_CP023623.1_1215430_1215535_+	NA|465aa|up_9|NZ_CP023623.1_1201666_1203061_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|up_8|NZ_CP023623.1_1203262_1203985_+	pfam06271, RDD, RDD family	NA|389aa|up_7|NZ_CP023623.1_1204016_1205183_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|165aa|up_6|NZ_CP023623.1_1205253_1205748_-	PRK00226, greA, transcription elongation factor GreA; Reviewed	NA|145aa|up_5|NZ_CP023623.1_1205933_1206368_-	pfam14155, DUF4307, Domain of unknown function (DUF4307)	NA|289aa|up_4|NZ_CP023623.1_1206469_1207336_+	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca	NA|89aa|up_3|NZ_CP023623.1_1207332_1207599_+	NA	NA|674aa|up_2|NZ_CP023623.1_1207585_1209607_+	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]	NA|243aa|up_1|NZ_CP023623.1_1209705_1210434_-	TIGR01065, Hypothetical_UPF0073_protein_yqfA	NA|263aa|up_0|NZ_CP023623.1_1210544_1211333_+	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional	NA|107aa|down_0|NZ_CP023623.1_1213953_1214274_+	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism]	NA|145aa|down_1|NZ_CP023623.1_1214426_1214861_+	pfam00934, PE, PE family	NA|55aa|down_2|NZ_CP023623.1_1214962_1215127_+	smart00637, CBD_II, CBD_II domain	NA|61aa|down_3|NZ_CP023623.1_1215138_1215321_+	NA	NA|35aa|down_4|NZ_CP023623.1_1215430_1215535_+	NA	NA|152aa|down_5|NZ_CP023623.1_1215512_1215968_+	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12	NA|854aa|down_6|NZ_CP023623.1_1216382_1218944_+	pfam00934, PE, PE family	NA|313aa|down_7|NZ_CP023623.1_1219161_1220100_-	PRK05439, PRK05439, pantothenate kinase; Provisional	NA|427aa|down_8|NZ_CP023623.1_1220487_1221768_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|276aa|down_9|NZ_CP023623.1_1221872_1222700_+	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	6	1572103-1573175	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|106aa|up_7|NZ_CP023623.1_1563866_1564184_+,NA	NA|103aa|up_9|NZ_CP023623.1_1561381_1561690_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023623.1_1561686_1563306_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023623.1_1563866_1564184_+	NA	NA|209aa|up_6|NZ_CP023623.1_1564318_1564945_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023623.1_1565010_1565343_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023623.1_1565358_1566615_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023623.1_1566742_1567954_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023623.1_1568026_1569505_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023623.1_1569501_1570887_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023623.1_1570964_1571999_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023623.1_1574028_1574430_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023623.1_1574426_1574684_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023623.1_1574766_1575726_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023623.1_1575750_1576713_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023623.1_1576846_1577449_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023623.1_1577529_1579497_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023623.1_1579514_1580339_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023623.1_1580507_1580990_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023623.1_1581061_1581886_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023623.1_1582082_1583021_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	7	2088224-2088478	2	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCNCCGTCGCCGCCNNTGCC	21	2	3	2088305-2088322|2088305-2088322|2088395-2088412	NZ_CP023623.1_401048-401031|NZ_CP023623.1_607389-607372|NZ_CP023623.1_3450100-3450083	NA	5	5	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|88aa|up_0|NZ_CP023623.1_2087583_2087847_-,NA	NA|165aa|up_9|NZ_CP023623.1_2073877_2074372_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023623.1_2074775_2075453_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023623.1_2075811_2078637_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023623.1_2078863_2079724_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023623.1_2079764_2080631_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023623.1_2080635_2082522_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023623.1_2082537_2084571_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023623.1_2084690_2086916_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023623.1_2087191_2087587_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023623.1_2087583_2087847_-	NA	NA|346aa|down_0|NZ_CP023623.1_2089615_2090653_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023623.1_2090652_2092020_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023623.1_2092193_2093630_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023623.1_2093665_2095117_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023623.1_2095146_2096097_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023623.1_2096111_2096528_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023623.1_2096805_2097228_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023623.1_2097276_2097579_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023623.1_2097575_2097890_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023623.1_2097889_2099623_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	8	2163317-2163421	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CAACCCAAACGGATTAATCGCGAARCCAGGGATCGT	36	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|157aa|up_9|NZ_CP023623.1_2152364_2152835_-,NA|136aa|up_1|NZ_CP023623.1_2159860_2160268_-,NA|127aa|down_6|NZ_CP023623.1_2176490_2176871_-	NA|157aa|up_9|NZ_CP023623.1_2152364_2152835_-	NA	NA|216aa|up_8|NZ_CP023623.1_2153174_2153822_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_7|NZ_CP023623.1_2153828_2156051_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_6|NZ_CP023623.1_2156088_2156532_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_5|NZ_CP023623.1_2156645_2157239_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_4|NZ_CP023623.1_2157321_2157927_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_3|NZ_CP023623.1_2158026_2159031_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_2|NZ_CP023623.1_2159130_2159883_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_1|NZ_CP023623.1_2159860_2160268_-	NA	NA|767aa|up_0|NZ_CP023623.1_2160402_2162703_+	PLN02892, PLN02892, isocitrate lyase	NA|988aa|down_0|NZ_CP023623.1_2167589_2170553_-	pfam00823, PPE, PPE family	NA|155aa|down_1|NZ_CP023623.1_2171001_2171466_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_2|NZ_CP023623.1_2171563_2172427_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_3|NZ_CP023623.1_2172464_2173736_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_4|NZ_CP023623.1_2174007_2175123_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_5|NZ_CP023623.1_2175113_2176454_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_6|NZ_CP023623.1_2176490_2176871_-	NA	NA|621aa|down_7|NZ_CP023623.1_2177027_2178890_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_8|NZ_CP023623.1_2178897_2179377_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_9|NZ_CP023623.1_2179613_2180387_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	9	2165295-2165491	7	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCGGAAGTGAGTAGCCATCCGGGAACACCGTAAACGGGCCTAACCC	47	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|157aa|up_9|NZ_CP023623.1_2152364_2152835_-,NA|136aa|up_1|NZ_CP023623.1_2159860_2160268_-,NA|127aa|down_6|NZ_CP023623.1_2176490_2176871_-	NA|157aa|up_9|NZ_CP023623.1_2152364_2152835_-	NA	NA|216aa|up_8|NZ_CP023623.1_2153174_2153822_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_7|NZ_CP023623.1_2153828_2156051_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_6|NZ_CP023623.1_2156088_2156532_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_5|NZ_CP023623.1_2156645_2157239_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_4|NZ_CP023623.1_2157321_2157927_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_3|NZ_CP023623.1_2158026_2159031_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_2|NZ_CP023623.1_2159130_2159883_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_1|NZ_CP023623.1_2159860_2160268_-	NA	NA|767aa|up_0|NZ_CP023623.1_2160402_2162703_+	PLN02892, PLN02892, isocitrate lyase	NA|988aa|down_0|NZ_CP023623.1_2167589_2170553_-	pfam00823, PPE, PPE family	NA|155aa|down_1|NZ_CP023623.1_2171001_2171466_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_2|NZ_CP023623.1_2171563_2172427_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_3|NZ_CP023623.1_2172464_2173736_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_4|NZ_CP023623.1_2174007_2175123_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_5|NZ_CP023623.1_2175113_2176454_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_6|NZ_CP023623.1_2176490_2176871_-	NA	NA|621aa|down_7|NZ_CP023623.1_2177027_2178890_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_8|NZ_CP023623.1_2178897_2179377_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_9|NZ_CP023623.1_2179613_2180387_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	10	2168755-2168974	8	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_2|NZ_CP023623.1_2159860_2160268_-,NA|127aa|down_5|NZ_CP023623.1_2176490_2176871_-	NA|216aa|up_9|NZ_CP023623.1_2153174_2153822_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_8|NZ_CP023623.1_2153828_2156051_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_7|NZ_CP023623.1_2156088_2156532_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_6|NZ_CP023623.1_2156645_2157239_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_5|NZ_CP023623.1_2157321_2157927_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_4|NZ_CP023623.1_2158026_2159031_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_3|NZ_CP023623.1_2159130_2159883_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_2|NZ_CP023623.1_2159860_2160268_-	NA	NA|767aa|up_1|NZ_CP023623.1_2160402_2162703_+	PLN02892, PLN02892, isocitrate lyase	NA|1460aa|up_0|NZ_CP023623.1_2162872_2167252_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023623.1_2171001_2171466_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023623.1_2171563_2172427_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023623.1_2172464_2173736_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023623.1_2174007_2175123_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023623.1_2175113_2176454_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023623.1_2176490_2176871_-	NA	NA|621aa|down_6|NZ_CP023623.1_2177027_2178890_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023623.1_2178897_2179377_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023623.1_2179613_2180387_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|215aa|down_9|NZ_CP023623.1_2181180_2181825_-	TIGR03085, TIGR03085, TIGR03085 family protein
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	11	3074388-3074468	9	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCGATCGCAAGCGCGGCGAAGCCG	24	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|118aa|down_2|NZ_CP023623.1_3076258_3076612_-,NA|97aa|down_3|NZ_CP023623.1_3076494_3076785_-,NA|158aa|down_8|NZ_CP023623.1_3081010_3081484_-	NA|92aa|up_9|NZ_CP023623.1_3068080_3068356_-	cd17267, RMtype1_S_EcoAO83I-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S	NA|541aa|up_8|NZ_CP023623.1_3068352_3069975_-	pfam02384, N6_Mtase, N-6 DNA Methylase	NA|139aa|up_7|NZ_CP023623.1_3070061_3070478_-	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|89aa|up_6|NZ_CP023623.1_3070474_3070741_-	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription]	NA|132aa|up_5|NZ_CP023623.1_3070766_3071162_-	COG3742, COG3742, Uncharacterized protein conserved in bacteria [Function unknown]	NA|90aa|up_4|NZ_CP023623.1_3071158_3071428_-	pfam07704, PSK_trans_fac, Rv0623-like transcription factor	NA|365aa|up_3|NZ_CP023623.1_3071437_3072532_-	cd17266, RMtype1_S_Sau1132ORF3780P-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Staphylococcus aureus subsp	NA|140aa|up_2|NZ_CP023623.1_3072528_3072948_-	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown]	NA|160aa|up_1|NZ_CP023623.1_3073021_3073501_-	pfam00186, DHFR_1, Dihydrofolate reductase	NA|267aa|up_0|NZ_CP023623.1_3073571_3074372_-	PRK01827, thyA, thymidylate synthase; Reviewed	NA|246aa|down_0|NZ_CP023623.1_3074527_3075265_+	pfam01738, DLH, Dienelactone hydrolase family	NA|261aa|down_1|NZ_CP023623.1_3075479_3076262_-	PRK07231, FabG-like, SDR family oxidoreductase	NA|118aa|down_2|NZ_CP023623.1_3076258_3076612_-	NA	NA|97aa|down_3|NZ_CP023623.1_3076494_3076785_-	NA	NA|395aa|down_4|NZ_CP023623.1_3076785_3077970_-	pfam00823, PPE, PPE family	NA|276aa|down_5|NZ_CP023623.1_3078049_3078877_-	pfam00934, PE, PE family	NA|383aa|down_6|NZ_CP023623.1_3079200_3080349_-	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|151aa|down_7|NZ_CP023623.1_3080472_3080925_-	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only]	NA|158aa|down_8|NZ_CP023623.1_3081010_3081484_-	NA	NA|246aa|down_9|NZ_CP023623.1_3081495_3082233_-	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	12	3119077-3120431	1,10,3	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-A,Type III-D,Type III-C,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	15,17,18	18	TypeIII-A,TypeIII-D,TypeIII-C,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_8|NZ_CP023623.1_3112356_3112611_-,NA|135aa|up_7|NZ_CP023623.1_3112758_3113163_+,NA|64aa|up_6|NZ_CP023623.1_3113159_3113351_+,NA|86aa|up_4|NZ_CP023623.1_3114937_3115195_+,NA|104aa|up_3|NZ_CP023623.1_3115299_3115611_+,NA|203aa|up_2|NZ_CP023623.1_3116030_3116639_+,NA	NA|92aa|up_9|NZ_CP023623.1_3111905_3112181_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023623.1_3112356_3112611_-	NA	NA|135aa|up_7|NZ_CP023623.1_3112758_3113163_+	NA	NA|64aa|up_6|NZ_CP023623.1_3113159_3113351_+	NA	NA|385aa|up_5|NZ_CP023623.1_3113549_3114704_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023623.1_3114937_3115195_+	NA	NA|104aa|up_3|NZ_CP023623.1_3115299_3115611_+	NA	NA|203aa|up_2|NZ_CP023623.1_3116030_3116639_+	NA	NA|470aa|up_1|NZ_CP023623.1_3116709_3118119_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023623.1_3118115_3118928_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023623.1_3120457_3121719_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023623.1_3123516_3123858_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023623.1_3123858_3124875_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023623.1_3124887_3126036_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023623.1_3126131_3127259_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023623.1_3127255_3128164_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023623.1_3128144_3128855_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023623.1_3128864_3129239_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023623.1_3129235_3131674_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023623.1_3131670_3132393_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	13	3121754-3123468	11,4,2	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-A,Type III-D,Type III-C,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	23,23,22	23	TypeIII-A,TypeIII-D,TypeIII-C,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_9|NZ_CP023623.1_3112356_3112611_-,NA|135aa|up_8|NZ_CP023623.1_3112758_3113163_+,NA|64aa|up_7|NZ_CP023623.1_3113159_3113351_+,NA|86aa|up_5|NZ_CP023623.1_3114937_3115195_+,NA|104aa|up_4|NZ_CP023623.1_3115299_3115611_+,NA|203aa|up_3|NZ_CP023623.1_3116030_3116639_+,NA	NA|85aa|up_9|NZ_CP023623.1_3112356_3112611_-	NA	NA|135aa|up_8|NZ_CP023623.1_3112758_3113163_+	NA	NA|64aa|up_7|NZ_CP023623.1_3113159_3113351_+	NA	NA|385aa|up_6|NZ_CP023623.1_3113549_3114704_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023623.1_3114937_3115195_+	NA	NA|104aa|up_4|NZ_CP023623.1_3115299_3115611_+	NA	NA|203aa|up_3|NZ_CP023623.1_3116030_3116639_+	NA	NA|470aa|up_2|NZ_CP023623.1_3116709_3118119_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023623.1_3118115_3118928_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023623.1_3120457_3121719_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023623.1_3123516_3123858_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023623.1_3123858_3124875_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023623.1_3124887_3126036_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023623.1_3126131_3127259_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023623.1_3127255_3128164_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023623.1_3128144_3128855_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023623.1_3128864_3129239_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023623.1_3129235_3131674_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023623.1_3131670_3132393_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023623.1_3132792_3133338_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	14	3740521-3741062	5	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|96aa|down_4|NZ_CP023623.1_3755133_3755421_-,NA|87aa|down_9|NZ_CP023623.1_3768541_3768802_-	NA|282aa|up_9|NZ_CP023623.1_3719772_3720618_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023623.1_3721092_3721533_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023623.1_3721566_3722436_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023623.1_3722456_3723467_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023623.1_3723751_3724384_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023623.1_3724450_3725680_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023623.1_3725962_3727312_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023623.1_3727323_3728463_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023623.1_3728459_3729191_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023623.1_3729199_3736771_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023623.1_3743033_3743291_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3148aa|down_1|NZ_CP023623.1_3743546_3752990_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023623.1_3753615_3754062_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023623.1_3754098_3754839_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023623.1_3755133_3755421_-	NA	NA|3717aa|down_5|NZ_CP023623.1_3755757_3766908_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023623.1_3767151_3767946_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023623.1_3768027_3768399_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023623.1_3768296_3768515_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023623.1_3768541_3768802_-	NA
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	15	3948165-3949232	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CANCGGCGGCACCGGCGGCANNGGCGGCNNCGGCGG	36	8	14	3948291-3948338|3948375-3948410|3948678-3948719|3948756-3948788|3948756-3948788|3948756-3948788|3948756-3948788|3948756-3948788|3948756-3948788|3948756-3948788|3948825-3948860|3948897-3948944|3948981-3949007|3949044-3949106	NZ_CP023623.1_3949470-3949517|NZ_CP023623.1_3949554-3949589|NZ_CP023623.1_3949260-3949301|NZ_CP023623.1_3946872-3946904|NZ_CP023623.1_3947214-3947246|NZ_CP023623.1_3947805-3947837|NZ_CP023623.1_3949338-3949370|NZ_CP023623.1_3932597-3932629|NZ_CP023623.1_3948156-3948188|NZ_CP023623.1_3947565-3947597|NZ_CP023623.1_3949407-3949442|NZ_CP023623.1_3949479-3949526|NZ_CP023623.1_3949563-3949589|NZ_CP023623.1_3949626-3949688	NA	13	13	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|280aa|down_2|NZ_CP023623.1_3953192_3954032_+	NA|64aa|up_9|NZ_CP023623.1_3921866_3922058_-	COG1141, Fer, Ferredoxin [Energy production and conversion]	NA|401aa|up_8|NZ_CP023623.1_3922272_3923475_+	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|374aa|up_7|NZ_CP023623.1_3923499_3924621_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|503aa|up_6|NZ_CP023623.1_3924691_3926200_+	PRK07867, PRK07867, acyl-CoA synthetase; Validated	NA|1379aa|up_5|NZ_CP023623.1_3926370_3930507_+	pfam00934, PE, PE family	NA|1902aa|up_4|NZ_CP023623.1_3930797_3936503_+	pfam00934, PE, PE family	NA|516aa|up_3|NZ_CP023623.1_3936669_3938217_-	PRK07586, PRK07586, acetolactate synthase large subunit	NA|279aa|up_2|NZ_CP023623.1_3938213_3939050_-	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]	NA|1782aa|up_1|NZ_CP023623.1_3939409_3944755_+	pfam00934, PE, PE family	NA|219aa|up_0|NZ_CP023623.1_3944883_3945540_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|549aa|down_0|NZ_CP023623.1_3950585_3952232_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|264aa|down_1|NZ_CP023623.1_3952305_3953097_+	PRK07799, PRK07799, crotonase/enoyl-CoA hydratase family protein	NA|280aa|down_2|NZ_CP023623.1_3953192_3954032_+	NA	NA|399aa|down_3|NZ_CP023623.1_3954086_3955283_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|237aa|down_4|NZ_CP023623.1_3955311_3956022_+	pfam06314, ADC, Acetoacetate decarboxylase (ADC)	NA|348aa|down_5|NZ_CP023623.1_3956086_3957130_-	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family	NA|304aa|down_6|NZ_CP023623.1_3957282_3958194_+	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]	NA|355aa|down_7|NZ_CP023623.1_3958209_3959274_+	PRK07937, PRK07937, lipid-transfer protein; Provisional	NA|344aa|down_8|NZ_CP023623.1_3960516_3961548_+	cd14952, NHL_PKND_like, NHL repeat domain of the protein kinase PknD	NA|175aa|down_9|NZ_CP023623.1_3961561_3962086_-	COG0663, PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]
GCF_002447875.1_ASM244787v1	NZ_CP023623	Mycobacterium tuberculosis strain MDRMA203 chromosome, complete genome	16	4110439-4110527	12	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|257aa|up_8|NZ_CP023623.1_4101025_4101796_-,NA|119aa|up_3|NZ_CP023623.1_4106930_4107287_+,NA|52aa|up_2|NZ_CP023623.1_4107386_4107542_+,NA|233aa|up_0|NZ_CP023623.1_4109543_4110242_-,NA|126aa|down_6|NZ_CP023623.1_4115762_4116140_+	NA|288aa|up_9|NZ_CP023623.1_4099407_4100271_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023623.1_4101025_4101796_-	NA	NA|549aa|up_7|NZ_CP023623.1_4101792_4103439_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023623.1_4103435_4104299_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023623.1_4104291_4105218_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023623.1_4105219_4106845_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023623.1_4106930_4107287_+	NA	NA|52aa|up_2|NZ_CP023623.1_4107386_4107542_+	NA	NA|652aa|up_1|NZ_CP023623.1_4107552_4109508_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023623.1_4109543_4110242_-	NA	NA|173aa|down_0|NZ_CP023623.1_4110587_4111106_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023623.1_4111106_4112090_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023623.1_4112082_4113276_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023623.1_4113281_4114103_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023623.1_4114234_4114918_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023623.1_4114917_4115655_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023623.1_4115762_4116140_+	NA	NA|225aa|down_7|NZ_CP023623.1_4116238_4116913_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023623.1_4117016_4117811_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023623.1_4117817_4118273_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
