assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	1	366429-367127	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366717-366758|366792-366824	NZ_CP023622.1_374748-374789|NZ_CP023622.1_373563-373595	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|101aa|up_4|NZ_CP023622.1_363441_363744_+,NA|161aa|down_1|NZ_CP023622.1_376537_377020_-,NA|410aa|down_5|NZ_CP023622.1_379136_380366_+	NA|262aa|up_9|NZ_CP023622.1_358136_358922_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023622.1_358910_359714_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023622.1_359723_361121_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023622.1_361299_363075_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023622.1_363217_363445_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023622.1_363441_363744_+	NA	NA|74aa|up_3|NZ_CP023622.1_363791_364013_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023622.1_364009_364435_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023622.1_364570_365203_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023622.1_365199_366108_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023622.1_375878_376550_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023622.1_376537_377020_-	NA	NA|239aa|down_2|NZ_CP023622.1_377077_377794_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023622.1_377895_378552_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023622.1_378621_379113_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023622.1_379136_380366_+	NA	NA|621aa|down_6|NZ_CP023622.1_380520_382383_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023622.1_382454_382841_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023622.1_382843_383506_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023622.1_383566_384451_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	2	691886-691962	2	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|72aa|up_9|NZ_CP023622.1_677570_677786_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|up_8|NZ_CP023622.1_677782_678190_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_7|NZ_CP023622.1_678249_678936_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_6|NZ_CP023622.1_679089_681723_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_5|NZ_CP023622.1_681745_684133_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_4|NZ_CP023622.1_684270_684993_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_3|NZ_CP023622.1_684989_685787_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_2|NZ_CP023622.1_685788_686676_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_1|NZ_CP023622.1_686681_687896_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_0|NZ_CP023622.1_688919_690365_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023622.1_693097_694648_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023622.1_694699_695092_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023622.1_695088_695346_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023622.1_695528_696764_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023622.1_697014_697428_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023622.1_697424_697661_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023622.1_697764_698271_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023622.1_698384_698855_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023622.1_698898_699660_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023622.1_699716_700028_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	3	926482-927429	1	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927265-927300|927265-927300|927265-927300	NZ_CP023622.1_674989-674954|NZ_CP023622.1_1213613-1213648|NZ_CP023622.1_2423580-2423545	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|184aa|down_2|NZ_CP023622.1_931439_931991_-,NA|81aa|down_8|NZ_CP023622.1_937454_937697_+	NA|685aa|up_9|NZ_CP023622.1_914118_916173_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023622.1_916338_917508_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023622.1_917595_918612_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023622.1_918773_919415_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023622.1_919495_920551_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023622.1_920602_920995_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023622.1_921052_921475_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023622.1_921436_921727_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023622.1_921831_922737_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023622.1_922755_923571_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|883aa|down_0|NZ_CP023622.1_927698_930347_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023622.1_930814_931459_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023622.1_931439_931991_-	NA	NA|218aa|down_3|NZ_CP023622.1_932140_932794_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023622.1_932864_933893_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023622.1_934581_935352_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023622.1_935438_936251_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023622.1_936318_937179_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023622.1_937454_937697_+	NA	NA|431aa|down_9|NZ_CP023622.1_937973_939266_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	4	1191189-1191297	3	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|544aa|up_9|NZ_CP023622.1_1180556_1182188_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023622.1_1182263_1183328_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023622.1_1183380_1183854_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023622.1_1183887_1184751_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023622.1_1184755_1185613_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023622.1_1185613_1186696_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023622.1_1186776_1187196_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023622.1_1187307_1187874_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023622.1_1187870_1188266_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023622.1_1188293_1190297_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023622.1_1192382_1194146_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023622.1_1194142_1194916_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023622.1_1194927_1195965_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023622.1_1196151_1196988_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023622.1_1197103_1197955_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023622.1_1198028_1199246_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023622.1_1199298_1200243_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023622.1_1200465_1201533_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023622.1_1201589_1202984_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023622.1_1203185_1203908_+	pfam06271, RDD, RDD family
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	5	1211823-1212670	4	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GGCGGTGTCGGCGGTGCCGGCGG	23	2	71	1212380-1212401|1212380-1212401|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515|1212497-1212515	NZ_CP023622.1_837294-837315|NZ_CP023622.1_1217508-1217529|NZ_CP023622.1_1572692-1572674|NZ_CP023622.1_674653-674635|NZ_CP023622.1_1213340-1213358|NZ_CP023622.1_1217481-1217499|NZ_CP023622.1_1217553-1217571|NZ_CP023622.1_1630564-1630546|NZ_CP023622.1_1633390-1633372|NZ_CP023622.1_1990668-1990650|NZ_CP023622.1_2061393-2061375|NZ_CP023622.1_2061840-2061822|NZ_CP023622.1_2061939-2061921|NZ_CP023622.1_2801896-2801878|NZ_CP023622.1_2805424-2805406|NZ_CP023622.1_150187-150205|NZ_CP023622.1_333766-333748|NZ_CP023622.1_335185-335167|NZ_CP023622.1_335638-335620|NZ_CP023622.1_335689-335671|NZ_CP023622.1_335698-335680|NZ_CP023622.1_337969-337951|NZ_CP023622.1_338098-338080|NZ_CP023622.1_338365-338347|NZ_CP023622.1_338394-338412|NZ_CP023622.1_338488-338470|NZ_CP023622.1_363019-363001|NZ_CP023622.1_443319-443301|NZ_CP023622.1_546663-546645|NZ_CP023622.1_623853-623871|NZ_CP023622.1_624075-624093|NZ_CP023622.1_673819-673801|NZ_CP023622.1_840077-840095|NZ_CP023622.1_1090852-1090870|NZ_CP023622.1_1091500-1091518|NZ_CP023622.1_1095558-1095540|NZ_CP023622.1_1212869-1212887|NZ_CP023622.1_1213259-1213277|NZ_CP023622.1_1217901-1217919|NZ_CP023622.1_1489076-1489058|NZ_CP023622.1_1618981-1618963|NZ_CP023622.1_1635903-1635885|NZ_CP023622.1_1635912-1635894|NZ_CP023622.1_1864182-1864164|NZ_CP023622.1_1864710-1864692|NZ_CP023622.1_1989942-1989924|NZ_CP023622.1_2001305-2001323|NZ_CP023622.1_2088663-2088645|NZ_CP023622.1_2303363-2303345|NZ_CP023622.1_2356814-2356796|NZ_CP023622.1_2419406-2419424|NZ_CP023622.1_2423493-2423475|NZ_CP023622.1_2568986-2568968|NZ_CP023622.1_2693284-2693302|NZ_CP023622.1_2795211-2795193|NZ_CP023622.1_2795793-2795775|NZ_CP023622.1_3054383-3054401|NZ_CP023622.1_3054482-3054500|NZ_CP023622.1_3705297-3705315|NZ_CP023622.1_3737274-3737256|NZ_CP023622.1_3737898-3737880|NZ_CP023622.1_3738141-3738123|NZ_CP023622.1_3738274-3738256|NZ_CP023622.1_3802119-3802137|NZ_CP023622.1_3802302-3802320|NZ_CP023622.1_3802470-3802488|NZ_CP023622.1_3930295-3930313|NZ_CP023622.1_3932025-3932043|NZ_CP023622.1_3940534-3940552|NZ_CP023622.1_4031509-4031491|NZ_CP023622.1_4094040-4094058	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|89aa|up_3|NZ_CP023622.1_1207255_1207522_+,NA|61aa|down_3|NZ_CP023622.1_1215088_1215271_+,NA|35aa|down_4|NZ_CP023622.1_1215380_1215485_+	NA|465aa|up_9|NZ_CP023622.1_1201589_1202984_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|up_8|NZ_CP023622.1_1203185_1203908_+	pfam06271, RDD, RDD family	NA|389aa|up_7|NZ_CP023622.1_1203939_1205106_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|165aa|up_6|NZ_CP023622.1_1205176_1205671_-	PRK00226, greA, transcription elongation factor GreA; Reviewed	NA|145aa|up_5|NZ_CP023622.1_1205856_1206291_-	pfam14155, DUF4307, Domain of unknown function (DUF4307)	NA|289aa|up_4|NZ_CP023622.1_1206392_1207259_+	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca	NA|89aa|up_3|NZ_CP023622.1_1207255_1207522_+	NA	NA|674aa|up_2|NZ_CP023622.1_1207508_1209530_+	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]	NA|243aa|up_1|NZ_CP023622.1_1209628_1210357_-	TIGR01065, Hypothetical_UPF0073_protein_yqfA	NA|263aa|up_0|NZ_CP023622.1_1210467_1211256_+	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional	NA|107aa|down_0|NZ_CP023622.1_1213903_1214224_+	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism]	NA|145aa|down_1|NZ_CP023622.1_1214376_1214811_+	pfam00934, PE, PE family	NA|56aa|down_2|NZ_CP023622.1_1214909_1215077_+	smart00637, CBD_II, CBD_II domain	NA|61aa|down_3|NZ_CP023622.1_1215088_1215271_+	NA	NA|35aa|down_4|NZ_CP023622.1_1215380_1215485_+	NA	NA|152aa|down_5|NZ_CP023622.1_1215462_1215918_+	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12	NA|854aa|down_6|NZ_CP023622.1_1216332_1218894_+	pfam00934, PE, PE family	NA|313aa|down_7|NZ_CP023622.1_1219111_1220050_-	PRK05439, PRK05439, pantothenate kinase; Provisional	NA|427aa|down_8|NZ_CP023622.1_1220437_1221718_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|276aa|down_9|NZ_CP023622.1_1221822_1222650_+	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	6	1636481-1636707	1	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CGGCGGCGCCGTTGGCGCCGTTGCCGCCGGCGCCGCCGTTGCCGCCG	47	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|38aa|up_8|NZ_CP023622.1_1622989_1623103_-,NA|137aa|up_7|NZ_CP023622.1_1623152_1623563_-,NA|288aa|down_2|NZ_CP023622.1_1640536_1641400_+	NA|162aa|up_9|NZ_CP023622.1_1622072_1622558_-	cd07820, SRPBCC_3, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins	NA|38aa|up_8|NZ_CP023622.1_1622989_1623103_-	NA	NA|137aa|up_7|NZ_CP023622.1_1623152_1623563_-	NA	NA|248aa|up_6|NZ_CP023622.1_1623579_1624323_-	pfam01182, Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	NA|304aa|up_5|NZ_CP023622.1_1624319_1625231_-	TIGR00534, Putative_OxPP_cycle_protein_OpcA, glucose-6-phosphate dehydrogenase assembly protein OpcA	NA|515aa|up_4|NZ_CP023622.1_1625283_1626828_-	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated	NA|374aa|up_3|NZ_CP023622.1_1626824_1627946_-	PRK03343, PRK03343, transaldolase; Validated	NA|701aa|up_2|NZ_CP023622.1_1627962_1630065_-	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism]	NA|1330aa|up_1|NZ_CP023622.1_1630503_1634493_-	pfam00934, PE, PE family	NA|309aa|up_0|NZ_CP023622.1_1634894_1635821_+	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional	NA|422aa|down_0|NZ_CP023622.1_1638237_1639503_+	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]	NA|329aa|down_1|NZ_CP023622.1_1639530_1640517_-	cd05286, QOR2, Quinone oxidoreductase (QOR)	NA|288aa|down_2|NZ_CP023622.1_1640536_1641400_+	NA	NA|311aa|down_3|NZ_CP023622.1_1641349_1642282_-	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]	NA|262aa|down_4|NZ_CP023622.1_1642393_1643179_-	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family	NA|314aa|down_5|NZ_CP023622.1_1643175_1644117_-	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms]	NA|592aa|down_6|NZ_CP023622.1_1644219_1645995_-	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein	NA|269aa|down_7|NZ_CP023622.1_1646042_1646849_+	COG2345, COG2345, Predicted transcriptional regulator [Transcription]	NA|847aa|down_8|NZ_CP023622.1_1646845_1649386_+	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB	NA|398aa|down_9|NZ_CP023622.1_1649382_1650576_+	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	7	2088135-2088389	2	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCNCCGTCGCCGCCNNTGCC	21	2	3	2088216-2088233|2088216-2088233|2088306-2088323	NZ_CP023622.1_401044-401027|NZ_CP023622.1_607308-607291|NZ_CP023622.1_3449997-3449980	NA	5	5	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|88aa|up_0|NZ_CP023622.1_2087494_2087758_-,NA	NA|165aa|up_9|NZ_CP023622.1_2073788_2074283_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023622.1_2074686_2075364_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023622.1_2075722_2078548_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023622.1_2078774_2079635_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023622.1_2079675_2080542_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023622.1_2080546_2082433_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023622.1_2082448_2084482_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023622.1_2084601_2086827_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023622.1_2087102_2087498_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023622.1_2087494_2087758_-	NA	NA|346aa|down_0|NZ_CP023622.1_2089526_2090564_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023622.1_2090563_2091931_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023622.1_2092104_2093541_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023622.1_2093576_2095028_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023622.1_2095057_2096008_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023622.1_2096022_2096439_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023622.1_2096716_2097139_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023622.1_2097187_2097490_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023622.1_2097486_2097801_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023622.1_2097800_2099534_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	8	2163227-2163331	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CAACCCAAACGGATTAATCGCGAAACCAGGGATCGT	36	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_2|NZ_CP023622.1_2159771_2160179_-,NA|127aa|down_6|NZ_CP023622.1_2176400_2176781_-	NA|216aa|up_9|NZ_CP023622.1_2153085_2153733_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_8|NZ_CP023622.1_2153739_2155962_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_7|NZ_CP023622.1_2155999_2156443_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_6|NZ_CP023622.1_2156556_2157150_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_5|NZ_CP023622.1_2157232_2157838_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_4|NZ_CP023622.1_2157937_2158942_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_3|NZ_CP023622.1_2159041_2159794_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_2|NZ_CP023622.1_2159771_2160179_-	NA	NA|368aa|up_1|NZ_CP023622.1_2160313_2161417_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_0|NZ_CP023622.1_2161416_2162613_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|988aa|down_0|NZ_CP023622.1_2167499_2170463_-	pfam00823, PPE, PPE family	NA|155aa|down_1|NZ_CP023622.1_2170911_2171376_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_2|NZ_CP023622.1_2171473_2172337_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_3|NZ_CP023622.1_2172374_2173646_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_4|NZ_CP023622.1_2173917_2175033_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_5|NZ_CP023622.1_2175023_2176364_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_6|NZ_CP023622.1_2176400_2176781_-	NA	NA|621aa|down_7|NZ_CP023622.1_2176937_2178800_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_8|NZ_CP023622.1_2178807_2179287_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_9|NZ_CP023622.1_2179523_2180297_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	9	2168665-2168884	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_3|NZ_CP023622.1_2159771_2160179_-,NA|127aa|down_5|NZ_CP023622.1_2176400_2176781_-	NA|741aa|up_9|NZ_CP023622.1_2153739_2155962_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_8|NZ_CP023622.1_2155999_2156443_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_7|NZ_CP023622.1_2156556_2157150_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_6|NZ_CP023622.1_2157232_2157838_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_5|NZ_CP023622.1_2157937_2158942_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_4|NZ_CP023622.1_2159041_2159794_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_3|NZ_CP023622.1_2159771_2160179_-	NA	NA|368aa|up_2|NZ_CP023622.1_2160313_2161417_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_1|NZ_CP023622.1_2161416_2162613_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|1460aa|up_0|NZ_CP023622.1_2162782_2167162_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023622.1_2170911_2171376_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023622.1_2171473_2172337_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023622.1_2172374_2173646_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023622.1_2173917_2175033_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023622.1_2175023_2176364_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023622.1_2176400_2176781_-	NA	NA|621aa|down_6|NZ_CP023622.1_2176937_2178800_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023622.1_2178807_2179287_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023622.1_2179523_2180297_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023622.1_2180300_2181068_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	10	3118974-3120328	2,7,3	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-B,Type III-A,Type III-C,Type III-D	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-B,TypeIII-A,TypeIII-C,TypeIII-D	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_8|NZ_CP023622.1_3112253_3112508_-,NA|135aa|up_7|NZ_CP023622.1_3112655_3113060_+,NA|64aa|up_6|NZ_CP023622.1_3113056_3113248_+,NA|86aa|up_4|NZ_CP023622.1_3114834_3115092_+,NA|104aa|up_3|NZ_CP023622.1_3115196_3115508_+,NA|203aa|up_2|NZ_CP023622.1_3115927_3116536_+,NA	NA|92aa|up_9|NZ_CP023622.1_3111802_3112078_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023622.1_3112253_3112508_-	NA	NA|135aa|up_7|NZ_CP023622.1_3112655_3113060_+	NA	NA|64aa|up_6|NZ_CP023622.1_3113056_3113248_+	NA	NA|385aa|up_5|NZ_CP023622.1_3113446_3114601_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023622.1_3114834_3115092_+	NA	NA|104aa|up_3|NZ_CP023622.1_3115196_3115508_+	NA	NA|203aa|up_2|NZ_CP023622.1_3115927_3116536_+	NA	NA|470aa|up_1|NZ_CP023622.1_3116606_3118016_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023622.1_3118012_3118825_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023622.1_3120354_3121616_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023622.1_3123413_3123755_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023622.1_3123755_3124772_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023622.1_3124784_3125933_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023622.1_3126028_3127156_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023622.1_3127152_3128061_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023622.1_3128041_3128752_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023622.1_3128761_3129136_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023622.1_3129132_3131571_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023622.1_3131567_3132290_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	11	3121651-3123365	8,4,3	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-B,Type III-A,Type III-C,Type III-D	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGA	36,36,35	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	23,23,22	23	TypeIII-B,TypeIII-A,TypeIII-C,TypeIII-D	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_9|NZ_CP023622.1_3112253_3112508_-,NA|135aa|up_8|NZ_CP023622.1_3112655_3113060_+,NA|64aa|up_7|NZ_CP023622.1_3113056_3113248_+,NA|86aa|up_5|NZ_CP023622.1_3114834_3115092_+,NA|104aa|up_4|NZ_CP023622.1_3115196_3115508_+,NA|203aa|up_3|NZ_CP023622.1_3115927_3116536_+,NA	NA|85aa|up_9|NZ_CP023622.1_3112253_3112508_-	NA	NA|135aa|up_8|NZ_CP023622.1_3112655_3113060_+	NA	NA|64aa|up_7|NZ_CP023622.1_3113056_3113248_+	NA	NA|385aa|up_6|NZ_CP023622.1_3113446_3114601_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023622.1_3114834_3115092_+	NA	NA|104aa|up_4|NZ_CP023622.1_3115196_3115508_+	NA	NA|203aa|up_3|NZ_CP023622.1_3115927_3116536_+	NA	NA|470aa|up_2|NZ_CP023622.1_3116606_3118016_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023622.1_3118012_3118825_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023622.1_3120354_3121616_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023622.1_3123413_3123755_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023622.1_3123755_3124772_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023622.1_3124784_3125933_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023622.1_3126028_3127156_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023622.1_3127152_3128061_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023622.1_3128041_3128752_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023622.1_3128761_3129136_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023622.1_3129132_3131571_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023622.1_3131567_3132290_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023622.1_3132689_3133235_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	12	3740468-3741009	5	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|96aa|down_4|NZ_CP023622.1_3755092_3755380_-,NA|87aa|down_9|NZ_CP023622.1_3768500_3768761_-	NA|282aa|up_9|NZ_CP023622.1_3719719_3720565_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023622.1_3721039_3721480_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023622.1_3721513_3722383_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023622.1_3722403_3723414_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023622.1_3723698_3724331_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023622.1_3724397_3725627_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023622.1_3725909_3727259_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023622.1_3727270_3728410_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023622.1_3728406_3729138_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023622.1_3729146_3736718_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023622.1_3742962_3743220_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023622.1_3743475_3752949_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023622.1_3753574_3754021_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023622.1_3754057_3754798_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023622.1_3755092_3755380_-	NA	NA|3717aa|down_5|NZ_CP023622.1_3755716_3766867_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023622.1_3767110_3767905_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023622.1_3767986_3768358_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023622.1_3768255_3768474_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023622.1_3768500_3768761_-	NA
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	13	3948142-3949893	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CANCGGCGGCACCGGCGGCNNCGGCGGNNNCGGCGG	36	2	9	3948733-3948768|3948733-3948768|3948733-3948768|3948733-3948768|3948733-3948768|3949624-3949650|3949624-3949650|3949624-3949650|3949624-3949650	NZ_CP023622.1_3946849-3946884|NZ_CP023622.1_3947191-3947226|NZ_CP023622.1_3947782-3947817|NZ_CP023622.1_3948133-3948168|NZ_CP023622.1_3932580-3932615|NZ_CP023622.1_361959-361985|NZ_CP023622.1_3941035-3941061|NZ_CP023622.1_3941371-3941397|NZ_CP023622.1_3941717-3941743	NA	21	21	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|280aa|down_2|NZ_CP023622.1_3953208_3954048_+	NA|255aa|up_9|NZ_CP023622.1_3919863_3920628_-	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|318aa|up_8|NZ_CP023622.1_3920853_3921807_-	PRK07792, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional	NA|64aa|up_7|NZ_CP023622.1_3921831_3922023_-	COG1141, Fer, Ferredoxin [Energy production and conversion]	NA|401aa|up_6|NZ_CP023622.1_3922237_3923440_+	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|374aa|up_5|NZ_CP023622.1_3923464_3924586_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|503aa|up_4|NZ_CP023622.1_3924656_3926165_+	PRK07867, PRK07867, acyl-CoA synthetase; Validated	NA|1385aa|up_3|NZ_CP023622.1_3926335_3930490_+	pfam00934, PE, PE family	NA|516aa|up_2|NZ_CP023622.1_3936654_3938202_-	PRK07586, PRK07586, acetolactate synthase large subunit	NA|279aa|up_1|NZ_CP023622.1_3938198_3939035_-	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]	NA|219aa|up_0|NZ_CP023622.1_3944869_3945526_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|549aa|down_0|NZ_CP023622.1_3950601_3952248_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|264aa|down_1|NZ_CP023622.1_3952321_3953113_+	PRK07799, PRK07799, crotonase/enoyl-CoA hydratase family protein	NA|280aa|down_2|NZ_CP023622.1_3953208_3954048_+	NA	NA|399aa|down_3|NZ_CP023622.1_3954102_3955299_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|237aa|down_4|NZ_CP023622.1_3955327_3956038_+	pfam06314, ADC, Acetoacetate decarboxylase (ADC)	NA|348aa|down_5|NZ_CP023622.1_3956102_3957146_-	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family	NA|304aa|down_6|NZ_CP023622.1_3957298_3958210_+	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]	NA|355aa|down_7|NZ_CP023622.1_3958225_3959290_+	PRK07937, PRK07937, lipid-transfer protein; Provisional	NA|395aa|down_8|NZ_CP023622.1_3959306_3960491_+	PRK08313, PRK08313, thiolase domain-containing protein	NA|344aa|down_9|NZ_CP023622.1_3960532_3961564_+	cd14952, NHL_PKND_like, NHL repeat domain of the protein kinase PknD
GCF_002447855.1_ASM244785v1	NZ_CP023622	Mycobacterium tuberculosis strain MDRDM827 chromosome, complete genome	14	4110457-4110545	9	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|257aa|up_8|NZ_CP023622.1_4101043_4101814_-,NA|119aa|up_3|NZ_CP023622.1_4106948_4107305_+,NA|52aa|up_2|NZ_CP023622.1_4107404_4107560_+,NA|233aa|up_0|NZ_CP023622.1_4109561_4110260_-,NA|126aa|down_6|NZ_CP023622.1_4115780_4116158_+	NA|288aa|up_9|NZ_CP023622.1_4099425_4100289_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023622.1_4101043_4101814_-	NA	NA|549aa|up_7|NZ_CP023622.1_4101810_4103457_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023622.1_4103453_4104317_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023622.1_4104309_4105236_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023622.1_4105237_4106863_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023622.1_4106948_4107305_+	NA	NA|52aa|up_2|NZ_CP023622.1_4107404_4107560_+	NA	NA|652aa|up_1|NZ_CP023622.1_4107570_4109526_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023622.1_4109561_4110260_-	NA	NA|173aa|down_0|NZ_CP023622.1_4110605_4111124_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023622.1_4111124_4112108_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023622.1_4112100_4113294_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023622.1_4113299_4114121_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023622.1_4114252_4114936_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023622.1_4114935_4115673_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023622.1_4115780_4116158_+	NA	NA|225aa|down_7|NZ_CP023622.1_4116256_4116931_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023622.1_4117036_4117831_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023622.1_4117837_4118293_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
