assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	1	334261-334597	1	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCCGCCGGCCCCGCCG	16	0	0	NA	NA	NA	4	4	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_0|NZ_CP023588.1_333080_333263_-,NA	NA|398aa|up_9|NZ_CP023588.1_323258_324452_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023588.1_324487_326170_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023588.1_326186_328382_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023588.1_328495_329629_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023588.1_329625_330246_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023588.1_330342_330924_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023588.1_330853_331579_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023588.1_331668_332589_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023588.1_332628_333057_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023588.1_333080_333263_-	NA	NA|838aa|down_0|NZ_CP023588.1_336462_338976_-	pfam00934, PE, PE family	NA|537aa|down_1|NZ_CP023588.1_339266_340877_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_2|NZ_CP023588.1_340900_341809_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_3|NZ_CP023588.1_342032_343928_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_4|NZ_CP023588.1_343924_345541_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_5|NZ_CP023588.1_345537_349530_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_6|NZ_CP023588.1_349526_349835_+	pfam00934, PE, PE family	NA|514aa|down_7|NZ_CP023588.1_349837_351379_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_8|NZ_CP023588.1_351427_351721_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_9|NZ_CP023588.1_351750_352041_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	2	366366-367064	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366654-366695|366729-366761	NZ_CP023588.1_374685-374726|NZ_CP023588.1_373500-373532	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|101aa|up_4|NZ_CP023588.1_363378_363681_+,NA|161aa|down_1|NZ_CP023588.1_376474_376957_-,NA|410aa|down_5|NZ_CP023588.1_379073_380303_+	NA|262aa|up_9|NZ_CP023588.1_358073_358859_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023588.1_358847_359651_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023588.1_359660_361058_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023588.1_361236_363012_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023588.1_363154_363382_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023588.1_363378_363681_+	NA	NA|74aa|up_3|NZ_CP023588.1_363728_363950_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023588.1_363946_364372_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023588.1_364507_365140_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023588.1_365136_366045_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023588.1_375815_376487_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023588.1_376474_376957_-	NA	NA|239aa|down_2|NZ_CP023588.1_377014_377731_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023588.1_377832_378489_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023588.1_378558_379050_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023588.1_379073_380303_+	NA	NA|621aa|down_6|NZ_CP023588.1_380457_382320_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023588.1_382391_382778_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023588.1_382780_383443_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023588.1_383503_384388_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	3	631087-631224	1	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGACCACGCCGGTG	18	2	3	631105-631122|631105-631122|631189-631206	NZ_CP023588.1_22466-22483|NZ_CP023588.1_1411805-1411822|NZ_CP023588.1_972988-973005	NA	3	3	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|54aa|up_7|NZ_CP023588.1_621925_622087_-,NA|478aa|up_0|NZ_CP023588.1_628102_629536_-,NA|450aa|down_2|NZ_CP023588.1_632859_634209_-,NA|93aa|down_5|NZ_CP023588.1_635739_636018_-	NA|325aa|up_9|NZ_CP023588.1_619695_620670_+	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB	NA|406aa|up_8|NZ_CP023588.1_620711_621929_+	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]	NA|54aa|up_7|NZ_CP023588.1_621925_622087_-	NA	NA|106aa|up_6|NZ_CP023588.1_622133_622451_+	pfam14012, DUF4229, Protein of unknown function (DUF4229)	NA|595aa|up_5|NZ_CP023588.1_622597_624382_+	pfam00934, PE, PE family	NA|336aa|up_4|NZ_CP023588.1_624277_625285_-	TIGR00747, 3-oxoacyl-_synthase_3, 3-oxoacyl-(acyl-carrier-protein) synthase III	NA|293aa|up_3|NZ_CP023588.1_625366_626245_-	TIGR00751, 14-dihydroxy-2-naphthoate_octaprenyltransferase, 1,4-dihydroxy-2-naphthoate octaprenyltransferase	NA|265aa|up_2|NZ_CP023588.1_626261_627056_+	PRK07823, PRK07823, S-methyl-5'-thioadenosine phosphorylase	NA|347aa|up_1|NZ_CP023588.1_627052_628093_+	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs	NA|478aa|up_0|NZ_CP023588.1_628102_629536_-	NA	NA|211aa|down_0|NZ_CP023588.1_631547_632180_+	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily	NA|221aa|down_1|NZ_CP023588.1_632176_632839_+	COG3222, COG3222, Uncharacterized protein conserved in bacteria [Function unknown]	NA|450aa|down_2|NZ_CP023588.1_632859_634209_-	NA	NA|381aa|down_3|NZ_CP023588.1_634220_635363_-	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase	NA|101aa|down_4|NZ_CP023588.1_635377_635680_-	pfam11829, DUF3349, Protein of unknown function (DUF3349)	NA|93aa|down_5|NZ_CP023588.1_635739_636018_-	NA	NA|418aa|down_6|NZ_CP023588.1_636014_637268_-	COG0306, PitA, Phosphate/sulphate permeases [Inorganic ion transport and metabolism]	NA|129aa|down_7|NZ_CP023588.1_637387_637774_-	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family	NA|295aa|down_8|NZ_CP023588.1_637836_638721_-	PRK05866, PRK05866, SDR family oxidoreductase	NA|301aa|down_9|NZ_CP023588.1_638816_639719_-	PRK08321, PRK08321, 1,4-dihydroxy-2-naphthoyl-CoA synthase
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	4	672459-672570	2	CRISPRCasFinder	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CCGCCGTTGCCGCCGTTGCCGCCG	24	1	2	672525-672545|672525-672545	NZ_CP023588.1_839935-839915|NZ_CP023588.1_1870302-1870322	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|114aa|up_6|NZ_CP023588.1_664846_665188_-,NA|56aa|up_5|NZ_CP023588.1_665238_665406_-,NA|164aa|down_1|NZ_CP023588.1_676911_677403_-	NA|89aa|up_9|NZ_CP023588.1_660807_661074_+	pfam08940, DUF1918, Domain of unknown function (DUF1918)	NA|693aa|up_8|NZ_CP023588.1_661099_663178_+	PRK08665, PRK08665, vitamin B12-dependent ribonucleotide reductase	NA|444aa|up_7|NZ_CP023588.1_663291_664623_-	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only]	NA|114aa|up_6|NZ_CP023588.1_664846_665188_-	NA	NA|56aa|up_5|NZ_CP023588.1_665238_665406_-	NA	NA|464aa|up_4|NZ_CP023588.1_665655_667047_-	PRK12484, PRK12484, nicotinate phosphoribosyltransferase; Provisional	NA|381aa|up_3|NZ_CP023588.1_667056_668199_-	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]	NA|389aa|up_2|NZ_CP023588.1_668383_669550_-	PRK07588, PRK07588, FAD-binding domain	csa3|435aa|up_1|NZ_CP023588.1_669652_670957_+	pfam08327, AHSA1, Activator of Hsp90 ATPase homolog 1-like protein	NA|262aa|up_0|NZ_CP023588.1_670970_671756_+	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only]	NA|253aa|down_0|NZ_CP023588.1_676024_676783_+	pfam01927, Mut7-C, Mut7-C RNAse domain	NA|164aa|down_1|NZ_CP023588.1_676911_677403_-	NA	NA|72aa|down_2|NZ_CP023588.1_677496_677712_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|down_3|NZ_CP023588.1_677708_678116_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|down_4|NZ_CP023588.1_678175_678862_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|down_5|NZ_CP023588.1_679015_681649_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|down_6|NZ_CP023588.1_681671_684059_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|down_7|NZ_CP023588.1_684196_684919_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|down_8|NZ_CP023588.1_684915_685713_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|down_9|NZ_CP023588.1_685714_686602_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	5	672639-673616	3	CRISPRCasFinder	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CCGCCGTTGCCGCCGTTGCCGCCG	24	1	2	673095-673115|673095-673115	NZ_CP023588.1_2031420-2031440|NZ_CP023588.1_3930198-3930178	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|114aa|up_6|NZ_CP023588.1_664846_665188_-,NA|56aa|up_5|NZ_CP023588.1_665238_665406_-,NA|164aa|down_1|NZ_CP023588.1_676911_677403_-	NA|89aa|up_9|NZ_CP023588.1_660807_661074_+	pfam08940, DUF1918, Domain of unknown function (DUF1918)	NA|693aa|up_8|NZ_CP023588.1_661099_663178_+	PRK08665, PRK08665, vitamin B12-dependent ribonucleotide reductase	NA|444aa|up_7|NZ_CP023588.1_663291_664623_-	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only]	NA|114aa|up_6|NZ_CP023588.1_664846_665188_-	NA	NA|56aa|up_5|NZ_CP023588.1_665238_665406_-	NA	NA|464aa|up_4|NZ_CP023588.1_665655_667047_-	PRK12484, PRK12484, nicotinate phosphoribosyltransferase; Provisional	NA|381aa|up_3|NZ_CP023588.1_667056_668199_-	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]	NA|389aa|up_2|NZ_CP023588.1_668383_669550_-	PRK07588, PRK07588, FAD-binding domain	csa3|435aa|up_1|NZ_CP023588.1_669652_670957_+	pfam08327, AHSA1, Activator of Hsp90 ATPase homolog 1-like protein	NA|262aa|up_0|NZ_CP023588.1_670970_671756_+	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only]	NA|253aa|down_0|NZ_CP023588.1_676024_676783_+	pfam01927, Mut7-C, Mut7-C RNAse domain	NA|164aa|down_1|NZ_CP023588.1_676911_677403_-	NA	NA|72aa|down_2|NZ_CP023588.1_677496_677712_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|down_3|NZ_CP023588.1_677708_678116_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|down_4|NZ_CP023588.1_678175_678862_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|down_5|NZ_CP023588.1_679015_681649_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|down_6|NZ_CP023588.1_681671_684059_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|down_7|NZ_CP023588.1_684196_684919_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|down_8|NZ_CP023588.1_684915_685713_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|down_9|NZ_CP023588.1_685714_686602_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	6	691812-691888	4	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|72aa|up_9|NZ_CP023588.1_677496_677712_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|up_8|NZ_CP023588.1_677708_678116_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_7|NZ_CP023588.1_678175_678862_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_6|NZ_CP023588.1_679015_681649_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_5|NZ_CP023588.1_681671_684059_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_4|NZ_CP023588.1_684196_684919_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_3|NZ_CP023588.1_684915_685713_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_2|NZ_CP023588.1_685714_686602_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_1|NZ_CP023588.1_686607_687822_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_0|NZ_CP023588.1_688845_690291_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023588.1_693023_694574_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023588.1_694625_695018_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023588.1_695014_695272_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023588.1_695454_696690_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023588.1_696940_697354_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023588.1_697350_697587_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023588.1_697690_698197_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023588.1_698310_698781_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023588.1_698824_699586_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023588.1_699642_699954_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	7	926359-927306	2	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927142-927177|927142-927177|927142-927177	NZ_CP023588.1_674915-674880|NZ_CP023588.1_1213486-1213521|NZ_CP023588.1_2423454-2423419	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|184aa|down_2|NZ_CP023588.1_931316_931868_-,NA|81aa|down_8|NZ_CP023588.1_937331_937574_+	NA|685aa|up_9|NZ_CP023588.1_913995_916050_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023588.1_916215_917385_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023588.1_917472_918489_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023588.1_918650_919292_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023588.1_919372_920428_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023588.1_920479_920872_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023588.1_920929_921352_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023588.1_921313_921604_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023588.1_921708_922614_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023588.1_922632_923448_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|883aa|down_0|NZ_CP023588.1_927575_930224_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023588.1_930691_931336_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023588.1_931316_931868_-	NA	NA|218aa|down_3|NZ_CP023588.1_932017_932671_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023588.1_932741_933770_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023588.1_934458_935229_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023588.1_935315_936128_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023588.1_936195_937056_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023588.1_937331_937574_+	NA	NA|431aa|down_9|NZ_CP023588.1_937850_939143_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	8	1191064-1191172	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|544aa|up_9|NZ_CP023588.1_1180431_1182063_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023588.1_1182138_1183203_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023588.1_1183255_1183729_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023588.1_1183762_1184626_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023588.1_1184630_1185488_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023588.1_1185488_1186571_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023588.1_1186651_1187071_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023588.1_1187182_1187749_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023588.1_1187745_1188141_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023588.1_1188168_1190172_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023588.1_1192257_1194021_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023588.1_1194017_1194791_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023588.1_1194802_1195840_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023588.1_1196026_1196863_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023588.1_1196978_1197830_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023588.1_1197903_1199121_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023588.1_1199173_1200118_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023588.1_1200340_1201408_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023588.1_1201464_1202859_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023588.1_1203060_1203783_+	pfam06271, RDD, RDD family
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	9	1571925-1572996	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	1	1	1572125-1572146	NZ_CP023588.1_1211811-1211790	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|106aa|up_7|NZ_CP023588.1_1563688_1564006_+,NA	NA|103aa|up_9|NZ_CP023588.1_1561203_1561512_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023588.1_1561508_1563128_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023588.1_1563688_1564006_+	NA	NA|209aa|up_6|NZ_CP023588.1_1564140_1564767_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023588.1_1564832_1565165_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023588.1_1565180_1566437_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023588.1_1566564_1567776_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023588.1_1567848_1569327_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023588.1_1569323_1570709_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023588.1_1570786_1571821_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023588.1_1573850_1574252_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023588.1_1574248_1574506_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023588.1_1574588_1575548_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023588.1_1575572_1576535_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023588.1_1576668_1577271_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023588.1_1577351_1579319_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023588.1_1579336_1580161_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023588.1_1580329_1580812_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023588.1_1580883_1581708_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023588.1_1581904_1582843_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	10	2087734-2088270	3	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCGCCGTNNCCGCCGNTGCC	21	3	5	2087998-2088015|2087998-2088015|2088097-2088114|2088097-2088114|2088187-2088204	NZ_CP023588.1_3926884-3926867|NZ_CP023588.1_3926980-3926963|NZ_CP023588.1_400981-400964|NZ_CP023588.1_607243-607226|NZ_CP023588.1_3449872-3449855	NA	9	9	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|88aa|up_0|NZ_CP023588.1_2087375_2087639_-,NA	NA|165aa|up_9|NZ_CP023588.1_2073669_2074164_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023588.1_2074567_2075245_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023588.1_2075603_2078429_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023588.1_2078655_2079516_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023588.1_2079556_2080423_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023588.1_2080427_2082314_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023588.1_2082329_2084363_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023588.1_2084482_2086708_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023588.1_2086983_2087379_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023588.1_2087375_2087639_-	NA	NA|346aa|down_0|NZ_CP023588.1_2089407_2090445_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023588.1_2090444_2091812_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023588.1_2091985_2093422_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023588.1_2093457_2094909_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023588.1_2094938_2095889_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023588.1_2095903_2096320_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023588.1_2096597_2097020_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023588.1_2097068_2097371_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023588.1_2097367_2097682_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023588.1_2097681_2099415_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	11	2168538-2168757	7	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_3|NZ_CP023588.1_2159644_2160052_-,NA|127aa|down_5|NZ_CP023588.1_2176273_2176654_-	NA|741aa|up_9|NZ_CP023588.1_2153612_2155835_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_8|NZ_CP023588.1_2155872_2156316_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_7|NZ_CP023588.1_2156429_2157023_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_6|NZ_CP023588.1_2157105_2157711_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_5|NZ_CP023588.1_2157810_2158815_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_4|NZ_CP023588.1_2158914_2159667_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_3|NZ_CP023588.1_2159644_2160052_-	NA	NA|368aa|up_2|NZ_CP023588.1_2160186_2161290_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_1|NZ_CP023588.1_2161289_2162486_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|1460aa|up_0|NZ_CP023588.1_2162655_2167035_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023588.1_2170784_2171249_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023588.1_2171346_2172210_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023588.1_2172247_2173519_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023588.1_2173790_2174906_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023588.1_2174896_2176237_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023588.1_2176273_2176654_-	NA	NA|621aa|down_6|NZ_CP023588.1_2176810_2178673_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023588.1_2178680_2179160_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023588.1_2179396_2180170_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023588.1_2180173_2180941_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	12	3118850-3120204	2,8,4	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-D,Type III-A,Type III-B,Type III-C	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-D,TypeIII-A,TypeIII-B,TypeIII-C	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_8|NZ_CP023588.1_3112129_3112384_-,NA|135aa|up_7|NZ_CP023588.1_3112531_3112936_+,NA|64aa|up_6|NZ_CP023588.1_3112932_3113124_+,NA|86aa|up_4|NZ_CP023588.1_3114710_3114968_+,NA|104aa|up_3|NZ_CP023588.1_3115072_3115384_+,NA|203aa|up_2|NZ_CP023588.1_3115803_3116412_+,NA	NA|92aa|up_9|NZ_CP023588.1_3111678_3111954_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023588.1_3112129_3112384_-	NA	NA|135aa|up_7|NZ_CP023588.1_3112531_3112936_+	NA	NA|64aa|up_6|NZ_CP023588.1_3112932_3113124_+	NA	NA|385aa|up_5|NZ_CP023588.1_3113322_3114477_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023588.1_3114710_3114968_+	NA	NA|104aa|up_3|NZ_CP023588.1_3115072_3115384_+	NA	NA|203aa|up_2|NZ_CP023588.1_3115803_3116412_+	NA	NA|470aa|up_1|NZ_CP023588.1_3116482_3117892_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023588.1_3117888_3118701_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023588.1_3120230_3121492_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023588.1_3123289_3123631_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023588.1_3123631_3124648_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023588.1_3124660_3125809_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023588.1_3125904_3127032_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023588.1_3127028_3127937_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023588.1_3127917_3128628_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023588.1_3128637_3129012_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023588.1_3129008_3131447_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023588.1_3131443_3132166_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	13	3121527-3123241	9,5,3	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-D,Type III-A,Type III-B,Type III-C	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	23,23,22	23	TypeIII-D,TypeIII-A,TypeIII-B,TypeIII-C	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_9|NZ_CP023588.1_3112129_3112384_-,NA|135aa|up_8|NZ_CP023588.1_3112531_3112936_+,NA|64aa|up_7|NZ_CP023588.1_3112932_3113124_+,NA|86aa|up_5|NZ_CP023588.1_3114710_3114968_+,NA|104aa|up_4|NZ_CP023588.1_3115072_3115384_+,NA|203aa|up_3|NZ_CP023588.1_3115803_3116412_+,NA	NA|85aa|up_9|NZ_CP023588.1_3112129_3112384_-	NA	NA|135aa|up_8|NZ_CP023588.1_3112531_3112936_+	NA	NA|64aa|up_7|NZ_CP023588.1_3112932_3113124_+	NA	NA|385aa|up_6|NZ_CP023588.1_3113322_3114477_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023588.1_3114710_3114968_+	NA	NA|104aa|up_4|NZ_CP023588.1_3115072_3115384_+	NA	NA|203aa|up_3|NZ_CP023588.1_3115803_3116412_+	NA	NA|470aa|up_2|NZ_CP023588.1_3116482_3117892_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023588.1_3117888_3118701_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023588.1_3120230_3121492_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023588.1_3123289_3123631_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023588.1_3123631_3124648_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023588.1_3124660_3125809_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023588.1_3125904_3127032_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023588.1_3127028_3127937_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023588.1_3127917_3128628_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023588.1_3128637_3129012_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023588.1_3129008_3131447_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023588.1_3131443_3132166_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023588.1_3132565_3133111_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	14	3740344-3740885	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|96aa|down_4|NZ_CP023588.1_3754986_3755274_-,NA|87aa|down_9|NZ_CP023588.1_3768394_3768655_-	NA|282aa|up_9|NZ_CP023588.1_3719595_3720441_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023588.1_3720915_3721356_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023588.1_3721389_3722259_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023588.1_3722279_3723290_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023588.1_3723574_3724207_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023588.1_3724273_3725503_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023588.1_3725785_3727135_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023588.1_3727146_3728286_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023588.1_3728282_3729014_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023588.1_3729022_3736594_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023588.1_3742856_3743114_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023588.1_3743369_3752843_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023588.1_3753468_3753915_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023588.1_3753951_3754692_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023588.1_3754986_3755274_-	NA	NA|3717aa|down_5|NZ_CP023588.1_3755610_3766761_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023588.1_3767004_3767799_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023588.1_3767880_3768252_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023588.1_3768149_3768368_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023588.1_3768394_3768655_-	NA
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	15	3762142-3762268	4	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTTGCCGATGCCGGTGTTGAAA	22	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|96aa|up_0|NZ_CP023588.1_3754986_3755274_-,NA|87aa|down_3|NZ_CP023588.1_3768394_3768655_-	NA|410aa|up_9|NZ_CP023588.1_3724273_3725503_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_8|NZ_CP023588.1_3725785_3727135_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_7|NZ_CP023588.1_3727146_3728286_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_6|NZ_CP023588.1_3728282_3729014_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_5|NZ_CP023588.1_3729022_3736594_-	pfam00823, PPE, PPE family	NA|86aa|up_4|NZ_CP023588.1_3742856_3743114_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|up_3|NZ_CP023588.1_3743369_3752843_-	pfam00823, PPE, PPE family	NA|149aa|up_2|NZ_CP023588.1_3753468_3753915_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|up_1|NZ_CP023588.1_3753951_3754692_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|up_0|NZ_CP023588.1_3754986_3755274_-	NA	NA|265aa|down_0|NZ_CP023588.1_3767004_3767799_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_1|NZ_CP023588.1_3767880_3768252_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_2|NZ_CP023588.1_3768149_3768368_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_3|NZ_CP023588.1_3768394_3768655_-	NA	NA|130aa|down_4|NZ_CP023588.1_3768769_3769159_+	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|98aa|down_5|NZ_CP023588.1_3769172_3769466_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|282aa|down_6|NZ_CP023588.1_3769462_3770308_-	PRK14193, PRK14193, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional	NA|92aa|down_7|NZ_CP023588.1_3770431_3770707_+	COG2161, StbD, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|86aa|down_8|NZ_CP023588.1_3770703_3770961_+	pfam06769, YoeB_toxin, YoeB-like toxin of bacterial type II toxin-antitoxin system	NA|397aa|down_9|NZ_CP023588.1_3771002_3772193_+	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain
GCF_002447175.1_ASM244717v1	NZ_CP023588	Mycobacterium tuberculosis strain TBDM425 chromosome, complete genome	16	4110314-4110402	10	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|257aa|up_8|NZ_CP023588.1_4100900_4101671_-,NA|119aa|up_3|NZ_CP023588.1_4106805_4107162_+,NA|52aa|up_2|NZ_CP023588.1_4107261_4107417_+,NA|233aa|up_0|NZ_CP023588.1_4109418_4110117_-,NA|126aa|down_6|NZ_CP023588.1_4115637_4116015_+	NA|288aa|up_9|NZ_CP023588.1_4099282_4100146_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023588.1_4100900_4101671_-	NA	NA|549aa|up_7|NZ_CP023588.1_4101667_4103314_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023588.1_4103310_4104174_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023588.1_4104166_4105093_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023588.1_4105094_4106720_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023588.1_4106805_4107162_+	NA	NA|52aa|up_2|NZ_CP023588.1_4107261_4107417_+	NA	NA|652aa|up_1|NZ_CP023588.1_4107427_4109383_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023588.1_4109418_4110117_-	NA	NA|173aa|down_0|NZ_CP023588.1_4110462_4110981_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023588.1_4110981_4111965_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023588.1_4111957_4113151_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023588.1_4113156_4113978_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023588.1_4114109_4114793_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023588.1_4114792_4115530_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023588.1_4115637_4116015_+	NA	NA|225aa|down_7|NZ_CP023588.1_4116113_4116788_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023588.1_4116893_4117688_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023588.1_4117694_4118150_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
