assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	1	333567-334365	1	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGGNGCCGCCGGNN	18	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_0|NZ_CP023585.1_333082_333265_-,NA	NA|398aa|up_9|NZ_CP023585.1_323260_324454_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023585.1_324489_326172_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023585.1_326188_328384_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023585.1_328497_329631_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023585.1_329627_330248_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023585.1_330344_330926_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023585.1_330855_331581_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023585.1_331670_332591_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023585.1_332630_333059_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023585.1_333082_333265_-	NA	NA|838aa|down_0|NZ_CP023585.1_336464_338978_-	pfam00934, PE, PE family	NA|537aa|down_1|NZ_CP023585.1_339268_340879_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_2|NZ_CP023585.1_340902_341811_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_3|NZ_CP023585.1_342034_343930_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_4|NZ_CP023585.1_343926_345543_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_5|NZ_CP023585.1_345539_349532_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_6|NZ_CP023585.1_349528_349837_+	pfam00934, PE, PE family	NA|514aa|down_7|NZ_CP023585.1_349839_351381_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_8|NZ_CP023585.1_351429_351723_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_9|NZ_CP023585.1_351752_352043_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	2	338009-338231	1	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	ATCCGCCGCTACCGCCGGTGCCGCCGGCGCCGAACAGCCCGCC	43	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_1|NZ_CP023585.1_333082_333265_-,NA	NA|561aa|up_9|NZ_CP023585.1_324489_326172_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_8|NZ_CP023585.1_326188_328384_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_7|NZ_CP023585.1_328497_329631_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_6|NZ_CP023585.1_329627_330248_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_5|NZ_CP023585.1_330344_330926_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_4|NZ_CP023585.1_330855_331581_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_3|NZ_CP023585.1_331670_332591_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_2|NZ_CP023585.1_332630_333059_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_1|NZ_CP023585.1_333082_333265_-	NA	NA|615aa|up_0|NZ_CP023585.1_333359_335204_-	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional	NA|537aa|down_0|NZ_CP023585.1_339268_340879_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_1|NZ_CP023585.1_340902_341811_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_2|NZ_CP023585.1_342034_343930_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_3|NZ_CP023585.1_343926_345543_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_4|NZ_CP023585.1_345539_349532_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_5|NZ_CP023585.1_349528_349837_+	pfam00934, PE, PE family	NA|514aa|down_6|NZ_CP023585.1_349839_351381_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_7|NZ_CP023585.1_351429_351723_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_8|NZ_CP023585.1_351752_352043_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]	NA|296aa|down_9|NZ_CP023585.1_352053_352941_+	pfam14011, ESX-1_EspG, EspG family
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	3	366368-367066	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366656-366697|366731-366763	NZ_CP023585.1_374687-374728|NZ_CP023585.1_373502-373534	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|101aa|up_4|NZ_CP023585.1_363380_363683_+,NA|161aa|down_1|NZ_CP023585.1_376476_376959_-,NA|410aa|down_5|NZ_CP023585.1_379075_380305_+	NA|262aa|up_9|NZ_CP023585.1_358075_358861_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023585.1_358849_359653_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023585.1_359662_361060_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023585.1_361238_363014_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023585.1_363156_363384_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023585.1_363380_363683_+	NA	NA|74aa|up_3|NZ_CP023585.1_363730_363952_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023585.1_363948_364374_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023585.1_364509_365142_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023585.1_365138_366047_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023585.1_375817_376489_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023585.1_376476_376959_-	NA	NA|239aa|down_2|NZ_CP023585.1_377016_377733_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023585.1_377834_378491_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023585.1_378560_379052_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023585.1_379075_380305_+	NA	NA|621aa|down_6|NZ_CP023585.1_380459_382322_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023585.1_382393_382780_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023585.1_382782_383445_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023585.1_383505_384390_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	4	672472-672583	2	CRISPRCasFinder	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CCGCCGTTGCCGCCGTTGCCGCCG	24	1	2	672538-672558|672538-672558	NZ_CP023585.1_839955-839935|NZ_CP023585.1_1870332-1870352	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|114aa|up_6|NZ_CP023585.1_664859_665201_-,NA|56aa|up_5|NZ_CP023585.1_665251_665419_-,NA|164aa|down_1|NZ_CP023585.1_676933_677425_-	NA|89aa|up_9|NZ_CP023585.1_660820_661087_+	pfam08940, DUF1918, Domain of unknown function (DUF1918)	NA|693aa|up_8|NZ_CP023585.1_661112_663191_+	PRK08665, PRK08665, vitamin B12-dependent ribonucleotide reductase	NA|444aa|up_7|NZ_CP023585.1_663304_664636_-	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only]	NA|114aa|up_6|NZ_CP023585.1_664859_665201_-	NA	NA|56aa|up_5|NZ_CP023585.1_665251_665419_-	NA	NA|464aa|up_4|NZ_CP023585.1_665668_667060_-	PRK12484, PRK12484, nicotinate phosphoribosyltransferase; Provisional	NA|381aa|up_3|NZ_CP023585.1_667069_668212_-	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]	NA|389aa|up_2|NZ_CP023585.1_668396_669563_-	PRK07588, PRK07588, FAD-binding domain	csa3|435aa|up_1|NZ_CP023585.1_669665_670970_+	pfam08327, AHSA1, Activator of Hsp90 ATPase homolog 1-like protein	NA|262aa|up_0|NZ_CP023585.1_670983_671769_+	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only]	NA|253aa|down_0|NZ_CP023585.1_676046_676805_+	pfam01927, Mut7-C, Mut7-C RNAse domain	NA|164aa|down_1|NZ_CP023585.1_676933_677425_-	NA	NA|72aa|down_2|NZ_CP023585.1_677518_677734_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|down_3|NZ_CP023585.1_677730_678138_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|down_4|NZ_CP023585.1_678197_678884_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|down_5|NZ_CP023585.1_679037_681671_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|down_6|NZ_CP023585.1_681693_684081_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|down_7|NZ_CP023585.1_684218_684941_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|down_8|NZ_CP023585.1_684937_685735_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|down_9|NZ_CP023585.1_685736_686624_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	5	672652-673629	3	CRISPRCasFinder	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CCGCCGTTGCCGCCGTTGCCGCCG	24	1	2	673108-673128|673108-673128	NZ_CP023585.1_2031450-2031470|NZ_CP023585.1_3930223-3930203	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|114aa|up_6|NZ_CP023585.1_664859_665201_-,NA|56aa|up_5|NZ_CP023585.1_665251_665419_-,NA|164aa|down_1|NZ_CP023585.1_676933_677425_-	NA|89aa|up_9|NZ_CP023585.1_660820_661087_+	pfam08940, DUF1918, Domain of unknown function (DUF1918)	NA|693aa|up_8|NZ_CP023585.1_661112_663191_+	PRK08665, PRK08665, vitamin B12-dependent ribonucleotide reductase	NA|444aa|up_7|NZ_CP023585.1_663304_664636_-	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only]	NA|114aa|up_6|NZ_CP023585.1_664859_665201_-	NA	NA|56aa|up_5|NZ_CP023585.1_665251_665419_-	NA	NA|464aa|up_4|NZ_CP023585.1_665668_667060_-	PRK12484, PRK12484, nicotinate phosphoribosyltransferase; Provisional	NA|381aa|up_3|NZ_CP023585.1_667069_668212_-	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]	NA|389aa|up_2|NZ_CP023585.1_668396_669563_-	PRK07588, PRK07588, FAD-binding domain	csa3|435aa|up_1|NZ_CP023585.1_669665_670970_+	pfam08327, AHSA1, Activator of Hsp90 ATPase homolog 1-like protein	NA|262aa|up_0|NZ_CP023585.1_670983_671769_+	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only]	NA|253aa|down_0|NZ_CP023585.1_676046_676805_+	pfam01927, Mut7-C, Mut7-C RNAse domain	NA|164aa|down_1|NZ_CP023585.1_676933_677425_-	NA	NA|72aa|down_2|NZ_CP023585.1_677518_677734_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|down_3|NZ_CP023585.1_677730_678138_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|down_4|NZ_CP023585.1_678197_678884_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|down_5|NZ_CP023585.1_679037_681671_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|down_6|NZ_CP023585.1_681693_684081_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|down_7|NZ_CP023585.1_684218_684941_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|down_8|NZ_CP023585.1_684937_685735_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|down_9|NZ_CP023585.1_685736_686624_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	6	691834-691910	4	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|72aa|up_9|NZ_CP023585.1_677518_677734_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|up_8|NZ_CP023585.1_677730_678138_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_7|NZ_CP023585.1_678197_678884_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_6|NZ_CP023585.1_679037_681671_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_5|NZ_CP023585.1_681693_684081_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_4|NZ_CP023585.1_684218_684941_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_3|NZ_CP023585.1_684937_685735_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_2|NZ_CP023585.1_685736_686624_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_1|NZ_CP023585.1_686629_687844_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_0|NZ_CP023585.1_688867_690313_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023585.1_693045_694596_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023585.1_694647_695040_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023585.1_695036_695294_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023585.1_695476_696712_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023585.1_696962_697376_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023585.1_697372_697609_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023585.1_697712_698219_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023585.1_698332_698803_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023585.1_698846_699608_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023585.1_699664_699976_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	7	926379-927326	2	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927162-927197|927162-927197|927162-927197	NZ_CP023585.1_674937-674902|NZ_CP023585.1_1213517-1213552|NZ_CP023585.1_2423483-2423448	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|184aa|down_2|NZ_CP023585.1_931336_931888_-,NA|81aa|down_8|NZ_CP023585.1_937351_937594_+	NA|685aa|up_9|NZ_CP023585.1_914015_916070_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023585.1_916235_917405_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023585.1_917492_918509_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023585.1_918670_919312_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023585.1_919392_920448_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023585.1_920499_920892_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023585.1_920949_921372_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023585.1_921333_921624_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023585.1_921728_922634_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023585.1_922652_923468_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|883aa|down_0|NZ_CP023585.1_927595_930244_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023585.1_930711_931356_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023585.1_931336_931888_-	NA	NA|218aa|down_3|NZ_CP023585.1_932037_932691_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023585.1_932761_933790_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023585.1_934478_935249_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023585.1_935335_936148_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023585.1_936215_937076_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023585.1_937351_937594_+	NA	NA|431aa|down_9|NZ_CP023585.1_937870_939163_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	8	1191093-1191201	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|544aa|up_9|NZ_CP023585.1_1180460_1182092_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023585.1_1182167_1183232_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023585.1_1183284_1183758_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023585.1_1183791_1184655_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023585.1_1184659_1185517_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023585.1_1185517_1186600_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023585.1_1186680_1187100_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023585.1_1187211_1187778_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023585.1_1187774_1188170_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023585.1_1188197_1190201_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023585.1_1192286_1194050_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023585.1_1194046_1194820_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023585.1_1194831_1195869_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023585.1_1196055_1196892_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023585.1_1197007_1197859_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023585.1_1197932_1199150_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023585.1_1199202_1200147_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023585.1_1200369_1201437_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023585.1_1201493_1202888_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023585.1_1203089_1203812_+	pfam06271, RDD, RDD family
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	9	1211727-1212574	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GGCGGTGTCGGCGGTGCCGGCGG	23	2	69	1212284-1212305|1212284-1212305|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419|1212401-1212419	NZ_CP023585.1_837191-837212|NZ_CP023585.1_1217412-1217433|NZ_CP023585.1_674601-674583|NZ_CP023585.1_1213244-1213262|NZ_CP023585.1_1217385-1217403|NZ_CP023585.1_1217457-1217475|NZ_CP023585.1_1630468-1630450|NZ_CP023585.1_1633293-1633275|NZ_CP023585.1_1990580-1990562|NZ_CP023585.1_2061304-2061286|NZ_CP023585.1_2061751-2061733|NZ_CP023585.1_2061850-2061832|NZ_CP023585.1_2801800-2801782|NZ_CP023585.1_2805328-2805310|NZ_CP023585.1_150187-150205|NZ_CP023585.1_335124-335106|NZ_CP023585.1_335577-335559|NZ_CP023585.1_335628-335610|NZ_CP023585.1_335637-335619|NZ_CP023585.1_337908-337890|NZ_CP023585.1_338304-338286|NZ_CP023585.1_338333-338351|NZ_CP023585.1_338427-338409|NZ_CP023585.1_362958-362940|NZ_CP023585.1_443274-443256|NZ_CP023585.1_546611-546593|NZ_CP023585.1_623801-623819|NZ_CP023585.1_624023-624041|NZ_CP023585.1_673767-673749|NZ_CP023585.1_839974-839992|NZ_CP023585.1_1090756-1090774|NZ_CP023585.1_1091404-1091422|NZ_CP023585.1_1095462-1095444|NZ_CP023585.1_1212773-1212791|NZ_CP023585.1_1213163-1213181|NZ_CP023585.1_1217805-1217823|NZ_CP023585.1_1488980-1488962|NZ_CP023585.1_1618885-1618867|NZ_CP023585.1_1635806-1635788|NZ_CP023585.1_1635815-1635797|NZ_CP023585.1_1864094-1864076|NZ_CP023585.1_1864622-1864604|NZ_CP023585.1_1989854-1989836|NZ_CP023585.1_2001216-2001234|NZ_CP023585.1_2088574-2088556|NZ_CP023585.1_2303265-2303247|NZ_CP023585.1_2356717-2356699|NZ_CP023585.1_2419309-2419327|NZ_CP023585.1_2423396-2423378|NZ_CP023585.1_2568890-2568872|NZ_CP023585.1_2693188-2693206|NZ_CP023585.1_2795115-2795097|NZ_CP023585.1_2795697-2795679|NZ_CP023585.1_3054288-3054306|NZ_CP023585.1_3054387-3054405|NZ_CP023585.1_3705198-3705216|NZ_CP023585.1_3737175-3737157|NZ_CP023585.1_3737799-3737781|NZ_CP023585.1_3738042-3738024|NZ_CP023585.1_3738175-3738157|NZ_CP023585.1_3802038-3802056|NZ_CP023585.1_3802221-3802239|NZ_CP023585.1_3802389-3802407|NZ_CP023585.1_3930212-3930230|NZ_CP023585.1_3931942-3931960|NZ_CP023585.1_3940449-3940467|NZ_CP023585.1_3948444-3948462|NZ_CP023585.1_4031388-4031370|NZ_CP023585.1_4093913-4093931	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|89aa|up_3|NZ_CP023585.1_1207159_1207426_+,NA|61aa|down_3|NZ_CP023585.1_1214992_1215175_+,NA|35aa|down_4|NZ_CP023585.1_1215284_1215389_+	NA|465aa|up_9|NZ_CP023585.1_1201493_1202888_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|up_8|NZ_CP023585.1_1203089_1203812_+	pfam06271, RDD, RDD family	NA|389aa|up_7|NZ_CP023585.1_1203843_1205010_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|165aa|up_6|NZ_CP023585.1_1205080_1205575_-	PRK00226, greA, transcription elongation factor GreA; Reviewed	NA|145aa|up_5|NZ_CP023585.1_1205760_1206195_-	pfam14155, DUF4307, Domain of unknown function (DUF4307)	NA|289aa|up_4|NZ_CP023585.1_1206296_1207163_+	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca	NA|89aa|up_3|NZ_CP023585.1_1207159_1207426_+	NA	NA|674aa|up_2|NZ_CP023585.1_1207412_1209434_+	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]	NA|243aa|up_1|NZ_CP023585.1_1209532_1210261_-	TIGR01065, Hypothetical_UPF0073_protein_yqfA	NA|263aa|up_0|NZ_CP023585.1_1210371_1211160_+	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional	NA|107aa|down_0|NZ_CP023585.1_1213807_1214128_+	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism]	NA|145aa|down_1|NZ_CP023585.1_1214280_1214715_+	pfam00934, PE, PE family	NA|56aa|down_2|NZ_CP023585.1_1214813_1214981_+	smart00637, CBD_II, CBD_II domain	NA|61aa|down_3|NZ_CP023585.1_1214992_1215175_+	NA	NA|35aa|down_4|NZ_CP023585.1_1215284_1215389_+	NA	NA|152aa|down_5|NZ_CP023585.1_1215366_1215822_+	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12	NA|854aa|down_6|NZ_CP023585.1_1216236_1218798_+	pfam00934, PE, PE family	NA|313aa|down_7|NZ_CP023585.1_1219015_1219954_-	PRK05439, PRK05439, pantothenate kinase; Provisional	NA|427aa|down_8|NZ_CP023585.1_1220341_1221622_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|276aa|down_9|NZ_CP023585.1_1221726_1222554_+	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	10	1571956-1573027	7	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|106aa|up_7|NZ_CP023585.1_1563719_1564037_+,NA	NA|103aa|up_9|NZ_CP023585.1_1561234_1561543_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023585.1_1561539_1563159_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023585.1_1563719_1564037_+	NA	NA|209aa|up_6|NZ_CP023585.1_1564171_1564798_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023585.1_1564863_1565196_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023585.1_1565211_1566468_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023585.1_1566595_1567807_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023585.1_1567879_1569358_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023585.1_1569354_1570740_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023585.1_1570817_1571852_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023585.1_1573881_1574283_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023585.1_1574279_1574537_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023585.1_1574619_1575579_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023585.1_1575603_1576566_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023585.1_1576699_1577302_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023585.1_1577382_1579350_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023585.1_1579367_1580192_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023585.1_1580360_1580843_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023585.1_1580914_1581739_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023585.1_1581935_1582874_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	11	2087764-2088300	3	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCGCCGTNNCCGCCGNTGCC	21	3	5	2088028-2088045|2088028-2088045|2088127-2088144|2088127-2088144|2088217-2088234	NZ_CP023585.1_3926909-3926892|NZ_CP023585.1_3927005-3926988|NZ_CP023585.1_400983-400966|NZ_CP023585.1_607256-607239|NZ_CP023585.1_3449897-3449880	NA	9	9	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|88aa|up_0|NZ_CP023585.1_2087405_2087669_-,NA	NA|165aa|up_9|NZ_CP023585.1_2073699_2074194_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023585.1_2074597_2075275_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023585.1_2075633_2078459_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023585.1_2078685_2079546_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023585.1_2079586_2080453_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023585.1_2080457_2082344_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023585.1_2082359_2084393_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023585.1_2084512_2086738_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023585.1_2087013_2087409_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023585.1_2087405_2087669_-	NA	NA|346aa|down_0|NZ_CP023585.1_2089437_2090475_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023585.1_2090474_2091842_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023585.1_2092015_2093452_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023585.1_2093487_2094939_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023585.1_2094968_2095919_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023585.1_2095933_2096350_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023585.1_2096627_2097050_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023585.1_2097098_2097401_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023585.1_2097397_2097712_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023585.1_2097711_2099445_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	12	2168567-2168786	8	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_2|NZ_CP023585.1_2159674_2160082_-,NA|127aa|down_5|NZ_CP023585.1_2176302_2176683_-	NA|216aa|up_9|NZ_CP023585.1_2152988_2153636_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_8|NZ_CP023585.1_2153642_2155865_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_7|NZ_CP023585.1_2155902_2156346_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_6|NZ_CP023585.1_2156459_2157053_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_5|NZ_CP023585.1_2157135_2157741_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_4|NZ_CP023585.1_2157840_2158845_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_3|NZ_CP023585.1_2158944_2159697_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_2|NZ_CP023585.1_2159674_2160082_-	NA	NA|368aa|up_1|NZ_CP023585.1_2160216_2161320_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_0|NZ_CP023585.1_2161319_2162516_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|155aa|down_0|NZ_CP023585.1_2170813_2171278_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023585.1_2171375_2172239_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023585.1_2172276_2173548_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023585.1_2173819_2174935_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023585.1_2174925_2176266_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023585.1_2176302_2176683_-	NA	NA|621aa|down_6|NZ_CP023585.1_2176839_2178702_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023585.1_2178709_2179189_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023585.1_2179425_2180199_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023585.1_2180202_2180970_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	13	3118879-3120233	2,9,4	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-A,Type III-B,Type III-D,Type III-C	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-A,TypeIII-B,TypeIII-D,TypeIII-C	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_8|NZ_CP023585.1_3112158_3112413_-,NA|135aa|up_7|NZ_CP023585.1_3112560_3112965_+,NA|64aa|up_6|NZ_CP023585.1_3112961_3113153_+,NA|86aa|up_4|NZ_CP023585.1_3114739_3114997_+,NA|104aa|up_3|NZ_CP023585.1_3115101_3115413_+,NA|203aa|up_2|NZ_CP023585.1_3115832_3116441_+,NA	NA|92aa|up_9|NZ_CP023585.1_3111707_3111983_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023585.1_3112158_3112413_-	NA	NA|135aa|up_7|NZ_CP023585.1_3112560_3112965_+	NA	NA|64aa|up_6|NZ_CP023585.1_3112961_3113153_+	NA	NA|385aa|up_5|NZ_CP023585.1_3113351_3114506_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023585.1_3114739_3114997_+	NA	NA|104aa|up_3|NZ_CP023585.1_3115101_3115413_+	NA	NA|203aa|up_2|NZ_CP023585.1_3115832_3116441_+	NA	NA|470aa|up_1|NZ_CP023585.1_3116511_3117921_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023585.1_3117917_3118730_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023585.1_3120259_3121521_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023585.1_3123318_3123660_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023585.1_3123660_3124677_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023585.1_3124689_3125838_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023585.1_3125933_3127061_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023585.1_3127057_3127966_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023585.1_3127946_3128657_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023585.1_3128666_3129041_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023585.1_3129037_3131476_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023585.1_3131472_3132195_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	14	3121556-3123270	10,5,3	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-A,Type III-B,Type III-D,Type III-C	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	23,23,22	23	TypeIII-A,TypeIII-B,TypeIII-D,TypeIII-C	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_9|NZ_CP023585.1_3112158_3112413_-,NA|135aa|up_8|NZ_CP023585.1_3112560_3112965_+,NA|64aa|up_7|NZ_CP023585.1_3112961_3113153_+,NA|86aa|up_5|NZ_CP023585.1_3114739_3114997_+,NA|104aa|up_4|NZ_CP023585.1_3115101_3115413_+,NA|203aa|up_3|NZ_CP023585.1_3115832_3116441_+,NA	NA|85aa|up_9|NZ_CP023585.1_3112158_3112413_-	NA	NA|135aa|up_8|NZ_CP023585.1_3112560_3112965_+	NA	NA|64aa|up_7|NZ_CP023585.1_3112961_3113153_+	NA	NA|385aa|up_6|NZ_CP023585.1_3113351_3114506_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023585.1_3114739_3114997_+	NA	NA|104aa|up_4|NZ_CP023585.1_3115101_3115413_+	NA	NA|203aa|up_3|NZ_CP023585.1_3115832_3116441_+	NA	NA|470aa|up_2|NZ_CP023585.1_3116511_3117921_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023585.1_3117917_3118730_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023585.1_3120259_3121521_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023585.1_3123318_3123660_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023585.1_3123660_3124677_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023585.1_3124689_3125838_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023585.1_3125933_3127061_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023585.1_3127057_3127966_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023585.1_3127946_3128657_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023585.1_3128666_3129041_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023585.1_3129037_3131476_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023585.1_3131472_3132195_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023585.1_3132594_3133140_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	15	3740369-3740910	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|96aa|down_4|NZ_CP023585.1_3755011_3755299_-,NA|87aa|down_9|NZ_CP023585.1_3768419_3768680_-	NA|282aa|up_9|NZ_CP023585.1_3719620_3720466_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023585.1_3720940_3721381_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023585.1_3721414_3722284_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023585.1_3722304_3723315_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023585.1_3723599_3724232_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023585.1_3724298_3725528_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023585.1_3725810_3727160_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023585.1_3727171_3728311_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023585.1_3728307_3729039_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023585.1_3729047_3736619_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023585.1_3742881_3743139_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023585.1_3743394_3752868_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023585.1_3753493_3753940_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023585.1_3753976_3754717_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023585.1_3755011_3755299_-	NA	NA|3717aa|down_5|NZ_CP023585.1_3755635_3766786_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023585.1_3767029_3767824_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023585.1_3767905_3768277_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023585.1_3768174_3768393_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023585.1_3768419_3768680_-	NA
GCF_002447115.1_ASM244711v1	NZ_CP023585	Mycobacterium tuberculosis strain MDRDM1098 chromosome, complete genome	16	4110330-4110418	11	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|257aa|up_8|NZ_CP023585.1_4100916_4101687_-,NA|119aa|up_3|NZ_CP023585.1_4106821_4107178_+,NA|52aa|up_2|NZ_CP023585.1_4107277_4107433_+,NA|233aa|up_0|NZ_CP023585.1_4109434_4110133_-,NA|126aa|down_6|NZ_CP023585.1_4115653_4116031_+	NA|288aa|up_9|NZ_CP023585.1_4099298_4100162_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023585.1_4100916_4101687_-	NA	NA|549aa|up_7|NZ_CP023585.1_4101683_4103330_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023585.1_4103326_4104190_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023585.1_4104182_4105109_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023585.1_4105110_4106736_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023585.1_4106821_4107178_+	NA	NA|52aa|up_2|NZ_CP023585.1_4107277_4107433_+	NA	NA|652aa|up_1|NZ_CP023585.1_4107443_4109399_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023585.1_4109434_4110133_-	NA	NA|173aa|down_0|NZ_CP023585.1_4110478_4110997_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023585.1_4110997_4111981_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023585.1_4111973_4113167_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023585.1_4113172_4113994_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023585.1_4114125_4114809_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023585.1_4114808_4115546_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023585.1_4115653_4116031_+	NA	NA|225aa|down_7|NZ_CP023585.1_4116129_4116804_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023585.1_4116909_4117704_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023585.1_4117710_4118166_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
