assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	1	335328-335893	1	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CCGCCGGCNCCGCCGNNGCCG	21	3	3	335748-335771|335793-335818|335840-335872	NZ_CP023584.1_338522-338545|NZ_CP023584.1_338556-338581|NZ_CP023584.1_338603-338635	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|61aa|up_0|NZ_CP023584.1_333105_333288_-,NA	NA|398aa|up_9|NZ_CP023584.1_323283_324477_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023584.1_324512_326195_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023584.1_326211_328407_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023584.1_328520_329654_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023584.1_329650_330271_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023584.1_330367_330949_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023584.1_330878_331604_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023584.1_331693_332614_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023584.1_332653_333082_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023584.1_333105_333288_-	NA	NA|838aa|down_0|NZ_CP023584.1_336495_339009_-	pfam00934, PE, PE family	NA|537aa|down_1|NZ_CP023584.1_339299_340910_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_2|NZ_CP023584.1_340933_341842_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_3|NZ_CP023584.1_342065_343961_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_4|NZ_CP023584.1_343957_345574_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_5|NZ_CP023584.1_345570_349563_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_6|NZ_CP023584.1_349559_349868_+	pfam00934, PE, PE family	NA|514aa|down_7|NZ_CP023584.1_349870_351412_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_8|NZ_CP023584.1_351460_351754_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_9|NZ_CP023584.1_351783_352074_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	2	337596-338015	2	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CGCCGNCGGNNCCGNCGG	18	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|61aa|up_0|NZ_CP023584.1_333105_333288_-,NA	NA|398aa|up_9|NZ_CP023584.1_323283_324477_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023584.1_324512_326195_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023584.1_326211_328407_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023584.1_328520_329654_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023584.1_329650_330271_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023584.1_330367_330949_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023584.1_330878_331604_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023584.1_331693_332614_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023584.1_332653_333082_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023584.1_333105_333288_-	NA	NA|537aa|down_0|NZ_CP023584.1_339299_340910_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_1|NZ_CP023584.1_340933_341842_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_2|NZ_CP023584.1_342065_343961_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_3|NZ_CP023584.1_343957_345574_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_4|NZ_CP023584.1_345570_349563_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_5|NZ_CP023584.1_349559_349868_+	pfam00934, PE, PE family	NA|514aa|down_6|NZ_CP023584.1_349870_351412_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_7|NZ_CP023584.1_351460_351754_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_8|NZ_CP023584.1_351783_352074_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]	NA|296aa|down_9|NZ_CP023584.1_352084_352972_+	pfam14011, ESX-1_EspG, EspG family
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	3	338040-338262	1	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	ATCCGCCGCTACCGCCGGTGCCGCCGGCGCCGAACAGCCCGCC	43	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|61aa|up_0|NZ_CP023584.1_333105_333288_-,NA	NA|398aa|up_9|NZ_CP023584.1_323283_324477_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023584.1_324512_326195_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023584.1_326211_328407_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023584.1_328520_329654_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023584.1_329650_330271_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023584.1_330367_330949_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023584.1_330878_331604_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023584.1_331693_332614_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023584.1_332653_333082_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023584.1_333105_333288_-	NA	NA|537aa|down_0|NZ_CP023584.1_339299_340910_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_1|NZ_CP023584.1_340933_341842_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_2|NZ_CP023584.1_342065_343961_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_3|NZ_CP023584.1_343957_345574_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_4|NZ_CP023584.1_345570_349563_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_5|NZ_CP023584.1_349559_349868_+	pfam00934, PE, PE family	NA|514aa|down_6|NZ_CP023584.1_349870_351412_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_7|NZ_CP023584.1_351460_351754_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_8|NZ_CP023584.1_351783_352074_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]	NA|296aa|down_9|NZ_CP023584.1_352084_352972_+	pfam14011, ESX-1_EspG, EspG family
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	4	366399-367097	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366687-366728|366762-366794	NZ_CP023584.1_374718-374759|NZ_CP023584.1_373533-373565	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|101aa|up_4|NZ_CP023584.1_363411_363714_+,NA|161aa|down_1|NZ_CP023584.1_376507_376990_-,NA|410aa|down_5|NZ_CP023584.1_379106_380336_+	NA|262aa|up_9|NZ_CP023584.1_358106_358892_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023584.1_358880_359684_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023584.1_359693_361091_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023584.1_361269_363045_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023584.1_363187_363415_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023584.1_363411_363714_+	NA	NA|74aa|up_3|NZ_CP023584.1_363761_363983_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023584.1_363979_364405_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023584.1_364540_365173_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023584.1_365169_366078_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023584.1_375848_376520_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023584.1_376507_376990_-	NA	NA|239aa|down_2|NZ_CP023584.1_377047_377764_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023584.1_377865_378522_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023584.1_378591_379083_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023584.1_379106_380336_+	NA	NA|621aa|down_6|NZ_CP023584.1_380490_382353_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023584.1_382424_382811_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023584.1_382813_383476_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023584.1_383536_384421_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	5	691870-691946	2	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA	NA|136aa|up_9|NZ_CP023584.1_677765_678173_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_8|NZ_CP023584.1_678232_678919_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_7|NZ_CP023584.1_679072_681706_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_6|NZ_CP023584.1_681728_684116_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_5|NZ_CP023584.1_684253_684976_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_4|NZ_CP023584.1_684972_685770_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_3|NZ_CP023584.1_685771_686659_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_2|NZ_CP023584.1_686664_687879_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_1|NZ_CP023584.1_688902_690348_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|479aa|up_0|NZ_CP023584.1_690344_691781_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023584.1_693081_694632_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023584.1_694683_695076_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023584.1_695072_695330_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023584.1_695512_696748_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023584.1_696998_697412_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023584.1_697408_697645_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023584.1_697748_698255_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023584.1_698368_698839_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023584.1_698882_699644_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023584.1_699700_700012_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	6	926466-927406	3	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927249-927284|927249-927284|927249-927284	NZ_CP023584.1_674972-674937|NZ_CP023584.1_1213591-1213626|NZ_CP023584.1_2423553-2423518	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA|184aa|down_2|NZ_CP023584.1_931416_931968_-,NA|81aa|down_8|NZ_CP023584.1_937431_937674_+	NA|685aa|up_9|NZ_CP023584.1_914102_916157_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023584.1_916322_917492_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023584.1_917579_918596_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023584.1_918757_919399_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023584.1_919479_920535_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023584.1_920586_920979_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023584.1_921036_921459_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023584.1_921420_921711_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023584.1_921815_922721_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023584.1_922739_923555_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|883aa|down_0|NZ_CP023584.1_927675_930324_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023584.1_930791_931436_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023584.1_931416_931968_-	NA	NA|218aa|down_3|NZ_CP023584.1_932117_932771_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023584.1_932841_933870_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023584.1_934558_935329_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023584.1_935415_936228_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023584.1_936295_937156_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023584.1_937431_937674_+	NA	NA|431aa|down_9|NZ_CP023584.1_937950_939243_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	7	1191158-1191266	3	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA	NA|544aa|up_9|NZ_CP023584.1_1180525_1182157_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023584.1_1182232_1183297_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023584.1_1183349_1183823_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023584.1_1183856_1184720_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023584.1_1184724_1185582_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023584.1_1185582_1186665_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023584.1_1186745_1187165_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023584.1_1187276_1187843_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023584.1_1187839_1188235_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023584.1_1188262_1190266_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023584.1_1192351_1194115_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023584.1_1194111_1194885_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023584.1_1194896_1195934_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023584.1_1196120_1196957_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023584.1_1197072_1197924_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023584.1_1197997_1199215_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023584.1_1199267_1200212_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023584.1_1200434_1201502_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023584.1_1201558_1202953_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023584.1_1203154_1203877_+	pfam06271, RDD, RDD family
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	8	1211792-1212648	4	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GGCGGTGTCGGCGGTGCCGGCGG	23	4	70	1212175-1212196|1212220-1212235|1212358-1212379|1212358-1212379|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493|1212475-1212493	NZ_CP023584.1_2960321-2960300|NZ_CP023584.1_2088452-2088437|NZ_CP023584.1_837278-837299|NZ_CP023584.1_1217486-1217507|NZ_CP023584.1_674636-674618|NZ_CP023584.1_1213318-1213336|NZ_CP023584.1_1217459-1217477|NZ_CP023584.1_1217531-1217549|NZ_CP023584.1_1630543-1630525|NZ_CP023584.1_1633369-1633351|NZ_CP023584.1_1990656-1990638|NZ_CP023584.1_2061380-2061362|NZ_CP023584.1_2061827-2061809|NZ_CP023584.1_2061926-2061908|NZ_CP023584.1_2801870-2801852|NZ_CP023584.1_2805398-2805380|NZ_CP023584.1_1636764-1636746|NZ_CP023584.1_150187-150205|NZ_CP023584.1_333728-333710|NZ_CP023584.1_335144-335126|NZ_CP023584.1_338335-338317|NZ_CP023584.1_338364-338382|NZ_CP023584.1_338458-338440|NZ_CP023584.1_362989-362971|NZ_CP023584.1_443322-443304|NZ_CP023584.1_546646-546628|NZ_CP023584.1_623836-623854|NZ_CP023584.1_624058-624076|NZ_CP023584.1_673811-673793|NZ_CP023584.1_840061-840079|NZ_CP023584.1_1090825-1090843|NZ_CP023584.1_1091473-1091491|NZ_CP023584.1_1095531-1095513|NZ_CP023584.1_1212847-1212865|NZ_CP023584.1_1213237-1213255|NZ_CP023584.1_1217879-1217897|NZ_CP023584.1_1489055-1489037|NZ_CP023584.1_1618507-1618489|NZ_CP023584.1_1618960-1618942|NZ_CP023584.1_1635882-1635864|NZ_CP023584.1_1635891-1635873|NZ_CP023584.1_1864170-1864152|NZ_CP023584.1_1864698-1864680|NZ_CP023584.1_1989930-1989912|NZ_CP023584.1_2001292-2001310|NZ_CP023584.1_2088650-2088632|NZ_CP023584.1_2303334-2303316|NZ_CP023584.1_2356786-2356768|NZ_CP023584.1_2419379-2419397|NZ_CP023584.1_2423466-2423448|NZ_CP023584.1_2568959-2568941|NZ_CP023584.1_2693258-2693276|NZ_CP023584.1_2795185-2795167|NZ_CP023584.1_2795767-2795749|NZ_CP023584.1_3054357-3054375|NZ_CP023584.1_3054456-3054474|NZ_CP023584.1_3705276-3705294|NZ_CP023584.1_3737253-3737235|NZ_CP023584.1_3737877-3737859|NZ_CP023584.1_3738120-3738102|NZ_CP023584.1_3738253-3738235|NZ_CP023584.1_3802116-3802134|NZ_CP023584.1_3802299-3802317|NZ_CP023584.1_3802467-3802485|NZ_CP023584.1_3930266-3930284|NZ_CP023584.1_3931996-3932014|NZ_CP023584.1_3940503-3940521|NZ_CP023584.1_3948498-3948516|NZ_CP023584.1_4031460-4031442|NZ_CP023584.1_4093982-4094000	NA	16	16	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|89aa|up_3|NZ_CP023584.1_1207224_1207491_+,NA|61aa|down_3|NZ_CP023584.1_1215066_1215249_+,NA|35aa|down_4|NZ_CP023584.1_1215358_1215463_+	NA|465aa|up_9|NZ_CP023584.1_1201558_1202953_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|up_8|NZ_CP023584.1_1203154_1203877_+	pfam06271, RDD, RDD family	NA|389aa|up_7|NZ_CP023584.1_1203908_1205075_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|165aa|up_6|NZ_CP023584.1_1205145_1205640_-	PRK00226, greA, transcription elongation factor GreA; Reviewed	NA|145aa|up_5|NZ_CP023584.1_1205825_1206260_-	pfam14155, DUF4307, Domain of unknown function (DUF4307)	NA|289aa|up_4|NZ_CP023584.1_1206361_1207228_+	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca	NA|89aa|up_3|NZ_CP023584.1_1207224_1207491_+	NA	NA|674aa|up_2|NZ_CP023584.1_1207477_1209499_+	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]	NA|243aa|up_1|NZ_CP023584.1_1209597_1210326_-	TIGR01065, Hypothetical_UPF0073_protein_yqfA	NA|263aa|up_0|NZ_CP023584.1_1210436_1211225_+	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional	NA|107aa|down_0|NZ_CP023584.1_1213881_1214202_+	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism]	NA|145aa|down_1|NZ_CP023584.1_1214354_1214789_+	pfam00934, PE, PE family	NA|55aa|down_2|NZ_CP023584.1_1214890_1215055_+	smart00637, CBD_II, CBD_II domain	NA|61aa|down_3|NZ_CP023584.1_1215066_1215249_+	NA	NA|35aa|down_4|NZ_CP023584.1_1215358_1215463_+	NA	NA|152aa|down_5|NZ_CP023584.1_1215440_1215896_+	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12	NA|854aa|down_6|NZ_CP023584.1_1216310_1218872_+	pfam00934, PE, PE family	NA|313aa|down_7|NZ_CP023584.1_1219089_1220028_-	PRK05439, PRK05439, pantothenate kinase; Provisional	NA|427aa|down_8|NZ_CP023584.1_1220415_1221696_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|276aa|down_9|NZ_CP023584.1_1221799_1222627_+	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	9	1572031-1573102	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|106aa|up_7|NZ_CP023584.1_1563794_1564112_+,NA	NA|103aa|up_9|NZ_CP023584.1_1561309_1561618_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023584.1_1561614_1563234_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023584.1_1563794_1564112_+	NA	NA|209aa|up_6|NZ_CP023584.1_1564246_1564873_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023584.1_1564938_1565271_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023584.1_1565286_1566543_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023584.1_1566670_1567882_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023584.1_1567954_1569433_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023584.1_1569429_1570815_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023584.1_1570892_1571927_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023584.1_1573956_1574358_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023584.1_1574354_1574612_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023584.1_1574694_1575654_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023584.1_1575678_1576641_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023584.1_1576774_1577377_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023584.1_1577457_1579425_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023584.1_1579442_1580267_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023584.1_1580435_1580918_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023584.1_1580989_1581814_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023584.1_1582010_1582949_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	10	1636460-1636686	2	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CGGCGGCGCCGTTGGCGCCGTTGCCGCCGGCGCCGCCGTTGCCGCCG	47	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|38aa|up_8|NZ_CP023584.1_1622968_1623082_-,NA|137aa|up_7|NZ_CP023584.1_1623131_1623542_-,NA|288aa|down_2|NZ_CP023584.1_1640524_1641388_+	NA|162aa|up_9|NZ_CP023584.1_1622051_1622537_-	cd07820, SRPBCC_3, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins	NA|38aa|up_8|NZ_CP023584.1_1622968_1623082_-	NA	NA|137aa|up_7|NZ_CP023584.1_1623131_1623542_-	NA	NA|248aa|up_6|NZ_CP023584.1_1623558_1624302_-	pfam01182, Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	NA|304aa|up_5|NZ_CP023584.1_1624298_1625210_-	TIGR00534, Putative_OxPP_cycle_protein_OpcA, glucose-6-phosphate dehydrogenase assembly protein OpcA	NA|515aa|up_4|NZ_CP023584.1_1625262_1626807_-	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated	NA|374aa|up_3|NZ_CP023584.1_1626803_1627925_-	PRK03343, PRK03343, transaldolase; Validated	NA|701aa|up_2|NZ_CP023584.1_1627941_1630044_-	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism]	NA|1330aa|up_1|NZ_CP023584.1_1630482_1634472_-	pfam00934, PE, PE family	NA|309aa|up_0|NZ_CP023584.1_1634873_1635800_+	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional	NA|422aa|down_0|NZ_CP023584.1_1638225_1639491_+	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]	NA|329aa|down_1|NZ_CP023584.1_1639518_1640505_-	cd05286, QOR2, Quinone oxidoreductase (QOR)	NA|288aa|down_2|NZ_CP023584.1_1640524_1641388_+	NA	NA|311aa|down_3|NZ_CP023584.1_1641337_1642270_-	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]	NA|262aa|down_4|NZ_CP023584.1_1642381_1643167_-	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family	NA|314aa|down_5|NZ_CP023584.1_1643163_1644105_-	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms]	NA|592aa|down_6|NZ_CP023584.1_1644207_1645983_-	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein	NA|269aa|down_7|NZ_CP023584.1_1646030_1646837_+	COG2345, COG2345, Predicted transcriptional regulator [Transcription]	NA|847aa|down_8|NZ_CP023584.1_1646833_1649374_+	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB	NA|398aa|down_9|NZ_CP023584.1_1649370_1650564_+	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	11	2088122-2088376	4	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GCCNCCGTCGCCGCCNNTGCC	21	2	3	2088203-2088220|2088203-2088220|2088293-2088310	NZ_CP023584.1_401014-400997|NZ_CP023584.1_607291-607274|NZ_CP023584.1_3449974-3449957	NA	5	5	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|88aa|up_0|NZ_CP023584.1_2087481_2087745_-,NA	NA|165aa|up_9|NZ_CP023584.1_2073775_2074270_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023584.1_2074673_2075351_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023584.1_2075709_2078535_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023584.1_2078761_2079622_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023584.1_2079662_2080529_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023584.1_2080533_2082420_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023584.1_2082435_2084469_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023584.1_2084588_2086814_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023584.1_2087089_2087485_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023584.1_2087481_2087745_-	NA	NA|346aa|down_0|NZ_CP023584.1_2089504_2090542_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023584.1_2090541_2091909_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023584.1_2092082_2093519_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023584.1_2093554_2095006_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023584.1_2095035_2095986_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023584.1_2096000_2096417_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023584.1_2096694_2097117_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023584.1_2097165_2097468_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023584.1_2097464_2097779_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023584.1_2097778_2099512_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	12	2168636-2168855	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|136aa|up_3|NZ_CP023584.1_2159742_2160150_-,NA|127aa|down_5|NZ_CP023584.1_2176371_2176752_-	NA|741aa|up_9|NZ_CP023584.1_2153710_2155933_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_8|NZ_CP023584.1_2155970_2156414_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_7|NZ_CP023584.1_2156527_2157121_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_6|NZ_CP023584.1_2157203_2157809_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_5|NZ_CP023584.1_2157908_2158913_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_4|NZ_CP023584.1_2159012_2159765_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_3|NZ_CP023584.1_2159742_2160150_-	NA	NA|368aa|up_2|NZ_CP023584.1_2160284_2161388_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_1|NZ_CP023584.1_2161387_2162584_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|1460aa|up_0|NZ_CP023584.1_2162753_2167133_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023584.1_2170882_2171347_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023584.1_2171444_2172308_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023584.1_2172345_2173617_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023584.1_2173888_2175004_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023584.1_2174994_2176335_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023584.1_2176371_2176752_-	NA	NA|621aa|down_6|NZ_CP023584.1_2176908_2178771_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023584.1_2178778_2179258_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023584.1_2179494_2180268_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023584.1_2180271_2181039_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	13	3118948-3120302	3,7,5	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type III-C,Type III-A,Type III-D,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-C,TypeIII-A,TypeIII-D,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|85aa|up_8|NZ_CP023584.1_3112227_3112482_-,NA|135aa|up_7|NZ_CP023584.1_3112629_3113034_+,NA|64aa|up_6|NZ_CP023584.1_3113030_3113222_+,NA|86aa|up_4|NZ_CP023584.1_3114808_3115066_+,NA|104aa|up_3|NZ_CP023584.1_3115170_3115482_+,NA|203aa|up_2|NZ_CP023584.1_3115901_3116510_+,NA	NA|92aa|up_9|NZ_CP023584.1_3111776_3112052_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023584.1_3112227_3112482_-	NA	NA|135aa|up_7|NZ_CP023584.1_3112629_3113034_+	NA	NA|64aa|up_6|NZ_CP023584.1_3113030_3113222_+	NA	NA|385aa|up_5|NZ_CP023584.1_3113420_3114575_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023584.1_3114808_3115066_+	NA	NA|104aa|up_3|NZ_CP023584.1_3115170_3115482_+	NA	NA|203aa|up_2|NZ_CP023584.1_3115901_3116510_+	NA	NA|470aa|up_1|NZ_CP023584.1_3116580_3117990_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023584.1_3117986_3118799_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023584.1_3120328_3121590_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023584.1_3123387_3123729_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023584.1_3123729_3124746_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023584.1_3124758_3125907_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023584.1_3126002_3127130_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023584.1_3127126_3128035_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023584.1_3128015_3128726_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023584.1_3128735_3129110_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023584.1_3129106_3131545_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023584.1_3131541_3132264_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	14	3121625-3123339	8,6,4	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type III-C,Type III-A,Type III-D,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	23,23,22	23	TypeIII-C,TypeIII-A,TypeIII-D,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|85aa|up_9|NZ_CP023584.1_3112227_3112482_-,NA|135aa|up_8|NZ_CP023584.1_3112629_3113034_+,NA|64aa|up_7|NZ_CP023584.1_3113030_3113222_+,NA|86aa|up_5|NZ_CP023584.1_3114808_3115066_+,NA|104aa|up_4|NZ_CP023584.1_3115170_3115482_+,NA|203aa|up_3|NZ_CP023584.1_3115901_3116510_+,NA	NA|85aa|up_9|NZ_CP023584.1_3112227_3112482_-	NA	NA|135aa|up_8|NZ_CP023584.1_3112629_3113034_+	NA	NA|64aa|up_7|NZ_CP023584.1_3113030_3113222_+	NA	NA|385aa|up_6|NZ_CP023584.1_3113420_3114575_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023584.1_3114808_3115066_+	NA	NA|104aa|up_4|NZ_CP023584.1_3115170_3115482_+	NA	NA|203aa|up_3|NZ_CP023584.1_3115901_3116510_+	NA	NA|470aa|up_2|NZ_CP023584.1_3116580_3117990_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023584.1_3117986_3118799_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023584.1_3120328_3121590_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023584.1_3123387_3123729_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023584.1_3123729_3124746_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023584.1_3124758_3125907_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023584.1_3126002_3127130_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023584.1_3127126_3128035_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023584.1_3128015_3128726_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023584.1_3128735_3129110_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023584.1_3129106_3131545_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023584.1_3131541_3132264_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023584.1_3132663_3133209_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	15	3740447-3740988	7	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA|96aa|down_4|NZ_CP023584.1_3755089_3755377_-,NA|87aa|down_9|NZ_CP023584.1_3768497_3768758_-	NA|282aa|up_9|NZ_CP023584.1_3719698_3720544_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023584.1_3721018_3721459_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023584.1_3721492_3722362_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023584.1_3722382_3723393_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023584.1_3723677_3724310_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023584.1_3724376_3725606_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023584.1_3725888_3727238_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023584.1_3727249_3728389_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023584.1_3728385_3729117_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023584.1_3729125_3736697_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023584.1_3742959_3743217_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023584.1_3743472_3752946_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023584.1_3753571_3754018_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023584.1_3754054_3754795_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023584.1_3755089_3755377_-	NA	NA|3717aa|down_5|NZ_CP023584.1_3755713_3766864_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023584.1_3767107_3767902_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023584.1_3767983_3768355_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023584.1_3768252_3768471_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023584.1_3768497_3768758_-	NA
GCF_002447095.1_ASM244709v1	NZ_CP023584	Mycobacterium tuberculosis strain MDRDM627 chromosome, complete genome	16	4110399-4110487	9	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|257aa|up_8|NZ_CP023584.1_4100985_4101756_-,NA|119aa|up_3|NZ_CP023584.1_4106890_4107247_+,NA|52aa|up_2|NZ_CP023584.1_4107346_4107502_+,NA|233aa|up_0|NZ_CP023584.1_4109503_4110202_-,NA|126aa|down_6|NZ_CP023584.1_4115722_4116100_+	NA|288aa|up_9|NZ_CP023584.1_4099367_4100231_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023584.1_4100985_4101756_-	NA	NA|549aa|up_7|NZ_CP023584.1_4101752_4103399_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023584.1_4103395_4104259_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023584.1_4104251_4105178_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023584.1_4105179_4106805_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023584.1_4106890_4107247_+	NA	NA|52aa|up_2|NZ_CP023584.1_4107346_4107502_+	NA	NA|652aa|up_1|NZ_CP023584.1_4107512_4109468_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023584.1_4109503_4110202_-	NA	NA|173aa|down_0|NZ_CP023584.1_4110547_4111066_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023584.1_4111066_4112050_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023584.1_4112042_4113236_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023584.1_4113241_4114063_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023584.1_4114194_4114878_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023584.1_4114877_4115615_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023584.1_4115722_4116100_+	NA	NA|225aa|down_7|NZ_CP023584.1_4116198_4116873_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023584.1_4116978_4117773_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023584.1_4117779_4118235_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
