assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	1	333651-334449	1	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGGNGCCGCCGGNN	18	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_0|NZ_CP023583.1_333166_333349_-,NA	NA|398aa|up_9|NZ_CP023583.1_323344_324538_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023583.1_324573_326256_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023583.1_326272_328468_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023583.1_328581_329715_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023583.1_329711_330332_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023583.1_330428_331010_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023583.1_330939_331665_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023583.1_331754_332675_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023583.1_332714_333143_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023583.1_333166_333349_-	NA	NA|838aa|down_0|NZ_CP023583.1_336548_339062_-	pfam00934, PE, PE family	NA|537aa|down_1|NZ_CP023583.1_339352_340963_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_2|NZ_CP023583.1_340986_341895_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_3|NZ_CP023583.1_342118_344014_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_4|NZ_CP023583.1_344010_345627_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1332aa|down_5|NZ_CP023583.1_345623_349619_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_6|NZ_CP023583.1_349615_349924_+	pfam00934, PE, PE family	NA|514aa|down_7|NZ_CP023583.1_349926_351468_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_8|NZ_CP023583.1_351516_351810_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_9|NZ_CP023583.1_351839_352130_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	2	338093-338315	1	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	ATCCGCCGCTACCGCCGGTGCCGCCGGCGCCGAACAGCCCGCC	43	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|61aa|up_1|NZ_CP023583.1_333166_333349_-,NA	NA|561aa|up_9|NZ_CP023583.1_324573_326256_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_8|NZ_CP023583.1_326272_328468_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_7|NZ_CP023583.1_328581_329715_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_6|NZ_CP023583.1_329711_330332_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_5|NZ_CP023583.1_330428_331010_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_4|NZ_CP023583.1_330939_331665_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_3|NZ_CP023583.1_331754_332675_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_2|NZ_CP023583.1_332714_333143_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_1|NZ_CP023583.1_333166_333349_-	NA	NA|949aa|up_0|NZ_CP023583.1_333443_336290_-	pfam00934, PE, PE family	NA|537aa|down_0|NZ_CP023583.1_339352_340963_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_1|NZ_CP023583.1_340986_341895_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_2|NZ_CP023583.1_342118_344014_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_3|NZ_CP023583.1_344010_345627_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1332aa|down_4|NZ_CP023583.1_345623_349619_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_5|NZ_CP023583.1_349615_349924_+	pfam00934, PE, PE family	NA|514aa|down_6|NZ_CP023583.1_349926_351468_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_7|NZ_CP023583.1_351516_351810_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_8|NZ_CP023583.1_351839_352130_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]	NA|296aa|down_9|NZ_CP023583.1_352140_353028_+	pfam14011, ESX-1_EspG, EspG family
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	3	366419-367117	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366707-366748|366782-366814	NZ_CP023583.1_374738-374779|NZ_CP023583.1_373553-373585	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|101aa|up_4|NZ_CP023583.1_363431_363734_+,NA|161aa|down_1|NZ_CP023583.1_376527_377010_-,NA|410aa|down_5|NZ_CP023583.1_379126_380356_+	NA|262aa|up_9|NZ_CP023583.1_358162_358948_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023583.1_358936_359740_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023583.1_359749_361147_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|580aa|up_6|NZ_CP023583.1_361325_363065_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023583.1_363207_363435_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023583.1_363431_363734_+	NA	NA|74aa|up_3|NZ_CP023583.1_363781_364003_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023583.1_363999_364425_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023583.1_364560_365193_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023583.1_365189_366098_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023583.1_375868_376540_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023583.1_376527_377010_-	NA	NA|239aa|down_2|NZ_CP023583.1_377067_377784_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023583.1_377885_378542_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023583.1_378611_379103_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023583.1_379126_380356_+	NA	NA|621aa|down_6|NZ_CP023583.1_380510_382373_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023583.1_382444_382831_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023583.1_382833_383496_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023583.1_383556_384441_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	4	691950-692026	2	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|72aa|up_9|NZ_CP023583.1_677635_677851_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|136aa|up_8|NZ_CP023583.1_677847_678255_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_7|NZ_CP023583.1_678314_679001_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_6|NZ_CP023583.1_679154_681788_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_5|NZ_CP023583.1_681810_684198_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_4|NZ_CP023583.1_684335_685058_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_3|NZ_CP023583.1_685054_685852_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|247aa|up_2|NZ_CP023583.1_685999_686740_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_1|NZ_CP023583.1_686745_687960_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_0|NZ_CP023583.1_688983_690429_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023583.1_693161_694712_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023583.1_694763_695156_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023583.1_695152_695410_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023583.1_695592_696828_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023583.1_697078_697492_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023583.1_697488_697725_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023583.1_697828_698335_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023583.1_698448_698919_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023583.1_698962_699724_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023583.1_699780_700092_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	5	926547-927494	2	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type I-A	CGGGGCCGGCGGNNCCGGCGG	21	1	3	927330-927365|927330-927365|927330-927365	NZ_CP023583.1_675054-675019|NZ_CP023583.1_1213631-1213666|NZ_CP023583.1_2423623-2423588	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|184aa|down_2|NZ_CP023583.1_931486_932038_-,NA|81aa|down_8|NZ_CP023583.1_937501_937744_+	NA|685aa|up_9|NZ_CP023583.1_914182_916237_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023583.1_916402_917572_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023583.1_917659_918676_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023583.1_918837_919479_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023583.1_919560_920616_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023583.1_920667_921060_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023583.1_921117_921540_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023583.1_921501_921792_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023583.1_921896_922802_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023583.1_922820_923636_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|877aa|down_0|NZ_CP023583.1_927763_930394_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023583.1_930861_931506_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023583.1_931486_932038_-	NA	NA|218aa|down_3|NZ_CP023583.1_932187_932841_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023583.1_932911_933940_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023583.1_934628_935399_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023583.1_935485_936298_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023583.1_936365_937226_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023583.1_937501_937744_+	NA	NA|431aa|down_9|NZ_CP023583.1_938020_939313_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	6	1191237-1191345	3	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA	NA|544aa|up_9|NZ_CP023583.1_1180604_1182236_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023583.1_1182311_1183376_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023583.1_1183428_1183902_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023583.1_1183935_1184799_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023583.1_1184803_1185661_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023583.1_1185661_1186744_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023583.1_1186824_1187244_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023583.1_1187355_1187922_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023583.1_1187918_1188314_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023583.1_1188341_1190345_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023583.1_1192430_1194194_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023583.1_1194190_1194964_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023583.1_1194975_1196013_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023583.1_1196199_1197036_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023583.1_1197151_1198003_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023583.1_1198076_1199294_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023583.1_1199346_1200291_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023583.1_1200513_1201581_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023583.1_1201637_1203032_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023583.1_1203233_1203956_+	pfam06271, RDD, RDD family
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	7	1211871-1212727	4	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GGCGGTGTCGGCGGTGCCGGCGG	23	4	72	1212254-1212275|1212299-1212314|1212437-1212458|1212437-1212458|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572|1212554-1212572	NZ_CP023583.1_2960374-2960353|NZ_CP023583.1_2088457-2088442|NZ_CP023583.1_837359-837380|NZ_CP023583.1_1217526-1217547|NZ_CP023583.1_674718-674700|NZ_CP023583.1_1213397-1213415|NZ_CP023583.1_1217499-1217517|NZ_CP023583.1_1217571-1217589|NZ_CP023583.1_1630541-1630523|NZ_CP023583.1_1633358-1633340|NZ_CP023583.1_1990663-1990645|NZ_CP023583.1_2061385-2061367|NZ_CP023583.1_2061832-2061814|NZ_CP023583.1_2061931-2061913|NZ_CP023583.1_2801932-2801914|NZ_CP023583.1_2805451-2805433|NZ_CP023583.1_1636753-1636735|NZ_CP023583.1_150188-150206|NZ_CP023583.1_335208-335190|NZ_CP023583.1_335661-335643|NZ_CP023583.1_335712-335694|NZ_CP023583.1_335721-335703|NZ_CP023583.1_337992-337974|NZ_CP023583.1_338388-338370|NZ_CP023583.1_338417-338435|NZ_CP023583.1_338511-338493|NZ_CP023583.1_363009-362991|NZ_CP023583.1_443375-443357|NZ_CP023583.1_546719-546701|NZ_CP023583.1_623909-623927|NZ_CP023583.1_624131-624149|NZ_CP023583.1_673884-673866|NZ_CP023583.1_840142-840160|NZ_CP023583.1_1090900-1090918|NZ_CP023583.1_1091548-1091566|NZ_CP023583.1_1095606-1095588|NZ_CP023583.1_1212926-1212944|NZ_CP023583.1_1213316-1213334|NZ_CP023583.1_1217890-1217908|NZ_CP023583.1_1489062-1489044|NZ_CP023583.1_1618505-1618487|NZ_CP023583.1_1618958-1618940|NZ_CP023583.1_1635871-1635853|NZ_CP023583.1_1635880-1635862|NZ_CP023583.1_1864154-1864136|NZ_CP023583.1_1864682-1864664|NZ_CP023583.1_1989937-1989919|NZ_CP023583.1_2001297-2001315|NZ_CP023583.1_2088655-2088637|NZ_CP023583.1_2303345-2303327|NZ_CP023583.1_2356797-2356779|NZ_CP023583.1_2419449-2419467|NZ_CP023583.1_2423536-2423518|NZ_CP023583.1_2569029-2569011|NZ_CP023583.1_2693323-2693341|NZ_CP023583.1_2795247-2795229|NZ_CP023583.1_2795829-2795811|NZ_CP023583.1_3054410-3054428|NZ_CP023583.1_3054509-3054527|NZ_CP023583.1_3705310-3705328|NZ_CP023583.1_3737286-3737268|NZ_CP023583.1_3737910-3737892|NZ_CP023583.1_3738153-3738135|NZ_CP023583.1_3738286-3738268|NZ_CP023583.1_3802131-3802149|NZ_CP023583.1_3802314-3802332|NZ_CP023583.1_3802482-3802500|NZ_CP023583.1_3930305-3930323|NZ_CP023583.1_3932044-3932062|NZ_CP023583.1_3940532-3940550|NZ_CP023583.1_4031510-4031492|NZ_CP023583.1_4094029-4094047	NA	16	16	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|89aa|up_3|NZ_CP023583.1_1207303_1207570_+,NA|61aa|down_3|NZ_CP023583.1_1215106_1215289_+,NA|35aa|down_4|NZ_CP023583.1_1215398_1215503_+	NA|465aa|up_9|NZ_CP023583.1_1201637_1203032_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|up_8|NZ_CP023583.1_1203233_1203956_+	pfam06271, RDD, RDD family	NA|389aa|up_7|NZ_CP023583.1_1203987_1205154_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|165aa|up_6|NZ_CP023583.1_1205224_1205719_-	PRK00226, greA, transcription elongation factor GreA; Reviewed	NA|145aa|up_5|NZ_CP023583.1_1205904_1206339_-	pfam14155, DUF4307, Domain of unknown function (DUF4307)	NA|289aa|up_4|NZ_CP023583.1_1206440_1207307_+	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca	NA|89aa|up_3|NZ_CP023583.1_1207303_1207570_+	NA	NA|674aa|up_2|NZ_CP023583.1_1207556_1209578_+	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]	NA|243aa|up_1|NZ_CP023583.1_1209676_1210405_-	TIGR01065, Hypothetical_UPF0073_protein_yqfA	NA|263aa|up_0|NZ_CP023583.1_1210515_1211304_+	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional	NA|107aa|down_0|NZ_CP023583.1_1213921_1214242_+	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism]	NA|145aa|down_1|NZ_CP023583.1_1214394_1214829_+	pfam00934, PE, PE family	NA|56aa|down_2|NZ_CP023583.1_1214927_1215095_+	smart00637, CBD_II, CBD_II domain	NA|61aa|down_3|NZ_CP023583.1_1215106_1215289_+	NA	NA|35aa|down_4|NZ_CP023583.1_1215398_1215503_+	NA	NA|152aa|down_5|NZ_CP023583.1_1215480_1215936_+	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12	NA|313aa|down_6|NZ_CP023583.1_1219100_1220039_-	PRK05439, PRK05439, pantothenate kinase; Provisional	NA|427aa|down_7|NZ_CP023583.1_1220426_1221707_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|276aa|down_8|NZ_CP023583.1_1221811_1222639_+	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|434aa|down_9|NZ_CP023583.1_1222849_1224151_+	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	8	1572037-1573109	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|106aa|up_7|NZ_CP023583.1_1563800_1564118_+,NA	NA|103aa|up_9|NZ_CP023583.1_1561315_1561624_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023583.1_1561620_1563240_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023583.1_1563800_1564118_+	NA	NA|209aa|up_6|NZ_CP023583.1_1564252_1564879_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023583.1_1564944_1565277_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023583.1_1565292_1566549_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023583.1_1566676_1567888_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023583.1_1567960_1569439_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023583.1_1569435_1570821_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023583.1_1570898_1571933_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023583.1_1573963_1574365_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023583.1_1574361_1574619_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023583.1_1574701_1575661_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023583.1_1575685_1576648_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023583.1_1576781_1577384_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023583.1_1577464_1579432_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023583.1_1579449_1580274_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023583.1_1580442_1580925_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023583.1_1580996_1581821_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023583.1_1582017_1582956_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	9	2088127-2088381	3	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCCNCCGTCGCCGCCNNTGCC	21	2	3	2088208-2088225|2088208-2088225|2088298-2088315	NZ_CP023583.1_401034-401017|NZ_CP023583.1_607364-607347|NZ_CP023583.1_3450016-3449999	NA	5	5	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|88aa|up_0|NZ_CP023583.1_2087486_2087750_-,NA	NA|165aa|up_9|NZ_CP023583.1_2073780_2074275_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023583.1_2074678_2075356_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023583.1_2075714_2078540_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023583.1_2078766_2079627_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023583.1_2079667_2080534_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023583.1_2080538_2082425_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023583.1_2082440_2084474_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023583.1_2084593_2086819_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023583.1_2087094_2087490_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023583.1_2087486_2087750_-	NA	NA|346aa|down_0|NZ_CP023583.1_2089518_2090556_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023583.1_2090555_2091923_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023583.1_2092096_2093533_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023583.1_2093568_2095020_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023583.1_2095049_2096000_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023583.1_2096014_2096431_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023583.1_2096708_2097131_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023583.1_2097179_2097482_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023583.1_2097478_2097793_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023583.1_2097792_2099526_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	10	2163208-2163312	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CAACCCAAACGGATTAATCGCGAAACCAGGGATCGT	36	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_2|NZ_CP023583.1_2159752_2160160_-,NA|127aa|down_6|NZ_CP023583.1_2176381_2176762_-	NA|216aa|up_9|NZ_CP023583.1_2153066_2153714_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_8|NZ_CP023583.1_2153720_2155943_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_7|NZ_CP023583.1_2155980_2156424_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_6|NZ_CP023583.1_2156537_2157131_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_5|NZ_CP023583.1_2157213_2157819_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_4|NZ_CP023583.1_2157918_2158923_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_3|NZ_CP023583.1_2159022_2159775_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_2|NZ_CP023583.1_2159752_2160160_-	NA	NA|368aa|up_1|NZ_CP023583.1_2160294_2161398_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_0|NZ_CP023583.1_2161397_2162594_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|988aa|down_0|NZ_CP023583.1_2167480_2170444_-	pfam00823, PPE, PPE family	NA|155aa|down_1|NZ_CP023583.1_2170892_2171357_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_2|NZ_CP023583.1_2171454_2172318_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_3|NZ_CP023583.1_2172355_2173627_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_4|NZ_CP023583.1_2173898_2175014_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_5|NZ_CP023583.1_2175004_2176345_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_6|NZ_CP023583.1_2176381_2176762_-	NA	NA|621aa|down_7|NZ_CP023583.1_2176918_2178781_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_8|NZ_CP023583.1_2178788_2179268_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_9|NZ_CP023583.1_2179504_2180278_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	11	2168646-2168865	7	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|136aa|up_3|NZ_CP023583.1_2159752_2160160_-,NA|127aa|down_5|NZ_CP023583.1_2176381_2176762_-	NA|741aa|up_9|NZ_CP023583.1_2153720_2155943_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_8|NZ_CP023583.1_2155980_2156424_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_7|NZ_CP023583.1_2156537_2157131_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_6|NZ_CP023583.1_2157213_2157819_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_5|NZ_CP023583.1_2157918_2158923_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_4|NZ_CP023583.1_2159022_2159775_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_3|NZ_CP023583.1_2159752_2160160_-	NA	NA|368aa|up_2|NZ_CP023583.1_2160294_2161398_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_1|NZ_CP023583.1_2161397_2162594_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|1460aa|up_0|NZ_CP023583.1_2162763_2167143_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023583.1_2170892_2171357_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023583.1_2171454_2172318_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023583.1_2172355_2173627_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023583.1_2173898_2175014_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023583.1_2175004_2176345_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023583.1_2176381_2176762_-	NA	NA|621aa|down_6|NZ_CP023583.1_2176918_2178781_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023583.1_2178788_2179268_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023583.1_2179504_2180278_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023583.1_2180281_2181049_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	12	3074303-3074383	8	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCGATCGCAAGCGCGGCGAAGCCG	24	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|118aa|down_2|NZ_CP023583.1_3076173_3076527_-,NA|97aa|down_3|NZ_CP023583.1_3076409_3076700_-,NA|158aa|down_8|NZ_CP023583.1_3080925_3081399_-	NA|92aa|up_9|NZ_CP023583.1_3067995_3068271_-	cd17267, RMtype1_S_EcoAO83I-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S	NA|541aa|up_8|NZ_CP023583.1_3068267_3069890_-	pfam02384, N6_Mtase, N-6 DNA Methylase	NA|139aa|up_7|NZ_CP023583.1_3069976_3070393_-	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|89aa|up_6|NZ_CP023583.1_3070389_3070656_-	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription]	NA|132aa|up_5|NZ_CP023583.1_3070681_3071077_-	COG3742, COG3742, Uncharacterized protein conserved in bacteria [Function unknown]	NA|90aa|up_4|NZ_CP023583.1_3071073_3071343_-	pfam07704, PSK_trans_fac, Rv0623-like transcription factor	NA|365aa|up_3|NZ_CP023583.1_3071352_3072447_-	cd17266, RMtype1_S_Sau1132ORF3780P-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Staphylococcus aureus subsp	NA|140aa|up_2|NZ_CP023583.1_3072443_3072863_-	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown]	NA|160aa|up_1|NZ_CP023583.1_3072936_3073416_-	pfam00186, DHFR_1, Dihydrofolate reductase	NA|267aa|up_0|NZ_CP023583.1_3073486_3074287_-	PRK01827, thyA, thymidylate synthase; Reviewed	NA|246aa|down_0|NZ_CP023583.1_3074442_3075180_+	pfam01738, DLH, Dienelactone hydrolase family	NA|261aa|down_1|NZ_CP023583.1_3075394_3076177_-	PRK07231, FabG-like, SDR family oxidoreductase	NA|118aa|down_2|NZ_CP023583.1_3076173_3076527_-	NA	NA|97aa|down_3|NZ_CP023583.1_3076409_3076700_-	NA	NA|395aa|down_4|NZ_CP023583.1_3076700_3077885_-	pfam00823, PPE, PPE family	NA|276aa|down_5|NZ_CP023583.1_3077964_3078792_-	pfam00934, PE, PE family	NA|383aa|down_6|NZ_CP023583.1_3079115_3080264_-	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|151aa|down_7|NZ_CP023583.1_3080387_3080840_-	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only]	NA|158aa|down_8|NZ_CP023583.1_3080925_3081399_-	NA	NA|246aa|down_9|NZ_CP023583.1_3081410_3082148_-	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	13	3118992-3120346	2,9,4	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-D,Type III-C,Type III-A,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-D,TypeIII-C,TypeIII-A,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_8|NZ_CP023583.1_3112271_3112526_-,NA|135aa|up_7|NZ_CP023583.1_3112673_3113078_+,NA|64aa|up_6|NZ_CP023583.1_3113074_3113266_+,NA|86aa|up_4|NZ_CP023583.1_3114852_3115110_+,NA|104aa|up_3|NZ_CP023583.1_3115214_3115526_+,NA|203aa|up_2|NZ_CP023583.1_3115945_3116554_+,NA	NA|92aa|up_9|NZ_CP023583.1_3111820_3112096_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023583.1_3112271_3112526_-	NA	NA|135aa|up_7|NZ_CP023583.1_3112673_3113078_+	NA	NA|64aa|up_6|NZ_CP023583.1_3113074_3113266_+	NA	NA|385aa|up_5|NZ_CP023583.1_3113464_3114619_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023583.1_3114852_3115110_+	NA	NA|104aa|up_3|NZ_CP023583.1_3115214_3115526_+	NA	NA|203aa|up_2|NZ_CP023583.1_3115945_3116554_+	NA	NA|470aa|up_1|NZ_CP023583.1_3116624_3118034_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023583.1_3118030_3118843_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023583.1_3120372_3121634_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023583.1_3123431_3123773_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023583.1_3123773_3124790_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023583.1_3124802_3125951_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023583.1_3126046_3127174_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023583.1_3127170_3128079_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023583.1_3128059_3128770_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023583.1_3128779_3129154_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023583.1_3129150_3131589_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023583.1_3131585_3132308_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	14	3121669-3123383	10,5,3	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Type III-D,Type III-C,Type III-A,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGA	36,36,35	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	23,23,22	23	TypeIII-D,TypeIII-C,TypeIII-A,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|85aa|up_9|NZ_CP023583.1_3112271_3112526_-,NA|135aa|up_8|NZ_CP023583.1_3112673_3113078_+,NA|64aa|up_7|NZ_CP023583.1_3113074_3113266_+,NA|86aa|up_5|NZ_CP023583.1_3114852_3115110_+,NA|104aa|up_4|NZ_CP023583.1_3115214_3115526_+,NA|203aa|up_3|NZ_CP023583.1_3115945_3116554_+,NA	NA|85aa|up_9|NZ_CP023583.1_3112271_3112526_-	NA	NA|135aa|up_8|NZ_CP023583.1_3112673_3113078_+	NA	NA|64aa|up_7|NZ_CP023583.1_3113074_3113266_+	NA	NA|385aa|up_6|NZ_CP023583.1_3113464_3114619_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023583.1_3114852_3115110_+	NA	NA|104aa|up_4|NZ_CP023583.1_3115214_3115526_+	NA	NA|203aa|up_3|NZ_CP023583.1_3115945_3116554_+	NA	NA|470aa|up_2|NZ_CP023583.1_3116624_3118034_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023583.1_3118030_3118843_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023583.1_3120372_3121634_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023583.1_3123431_3123773_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023583.1_3123773_3124790_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023583.1_3124802_3125951_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023583.1_3126046_3127174_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023583.1_3127170_3128079_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023583.1_3128059_3128770_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023583.1_3128779_3129154_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023583.1_3129150_3131589_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023583.1_3131585_3132308_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023583.1_3132707_3133253_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	15	3740471-3741012	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|96aa|down_4|NZ_CP023583.1_3755095_3755383_-,NA|87aa|down_9|NZ_CP023583.1_3768503_3768764_-	NA|384aa|up_9|NZ_CP023583.1_3718390_3719542_+	COG1820, NagA, N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]	NA|282aa|up_8|NZ_CP023583.1_3719732_3720578_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_7|NZ_CP023583.1_3721052_3721493_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_6|NZ_CP023583.1_3721526_3722396_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_5|NZ_CP023583.1_3722416_3723427_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_4|NZ_CP023583.1_3723711_3724344_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_3|NZ_CP023583.1_3724410_3725640_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_2|NZ_CP023583.1_3725922_3727272_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_1|NZ_CP023583.1_3727283_3728423_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_0|NZ_CP023583.1_3728419_3729151_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|86aa|down_0|NZ_CP023583.1_3742965_3743223_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023583.1_3743478_3752952_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023583.1_3753577_3754024_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023583.1_3754060_3754801_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023583.1_3755095_3755383_-	NA	NA|3717aa|down_5|NZ_CP023583.1_3755719_3766870_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023583.1_3767113_3767908_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023583.1_3767989_3768361_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023583.1_3768258_3768477_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023583.1_3768503_3768764_-	NA
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	16	3948140-3949891	7	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	CANCGGCGGCACCGGCGGCNNCGGCGGNNNCGGCGG	36	2	9	3948731-3948766|3948731-3948766|3948731-3948766|3948731-3948766|3948731-3948766|3949622-3949648|3949622-3949648|3949622-3949648|3949622-3949648	NZ_CP023583.1_3946838-3946873|NZ_CP023583.1_3947180-3947215|NZ_CP023583.1_3947780-3947815|NZ_CP023583.1_3948131-3948166|NZ_CP023583.1_3932599-3932634|NZ_CP023583.1_361985-362011|NZ_CP023583.1_3941033-3941059|NZ_CP023583.1_3941369-3941395|NZ_CP023583.1_3941715-3941741	NA	21	21	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|280aa|down_2|NZ_CP023583.1_3953206_3954046_+	NA|255aa|up_9|NZ_CP023583.1_3919873_3920638_-	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|318aa|up_8|NZ_CP023583.1_3920863_3921817_-	PRK07792, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional	NA|64aa|up_7|NZ_CP023583.1_3921841_3922033_-	COG1141, Fer, Ferredoxin [Energy production and conversion]	NA|401aa|up_6|NZ_CP023583.1_3922247_3923450_+	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|374aa|up_5|NZ_CP023583.1_3923474_3924596_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|503aa|up_4|NZ_CP023583.1_3924666_3926175_+	PRK07867, PRK07867, acyl-CoA synthetase; Validated	NA|1385aa|up_3|NZ_CP023583.1_3926345_3930500_+	pfam00934, PE, PE family	NA|516aa|up_2|NZ_CP023583.1_3936652_3938200_-	PRK07586, PRK07586, acetolactate synthase large subunit	NA|279aa|up_1|NZ_CP023583.1_3938196_3939033_-	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]	NA|219aa|up_0|NZ_CP023583.1_3944858_3945515_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|549aa|down_0|NZ_CP023583.1_3950599_3952246_-	PRK07798, PRK07798, acyl-CoA synthetase; Validated	NA|264aa|down_1|NZ_CP023583.1_3952319_3953111_+	PRK07799, PRK07799, crotonase/enoyl-CoA hydratase family protein	NA|280aa|down_2|NZ_CP023583.1_3953206_3954046_+	NA	NA|399aa|down_3|NZ_CP023583.1_3954100_3955297_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|237aa|down_4|NZ_CP023583.1_3955325_3956036_+	pfam06314, ADC, Acetoacetate decarboxylase (ADC)	NA|348aa|down_5|NZ_CP023583.1_3956100_3957144_-	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family	NA|304aa|down_6|NZ_CP023583.1_3957296_3958208_+	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]	NA|355aa|down_7|NZ_CP023583.1_3958223_3959288_+	PRK07937, PRK07937, lipid-transfer protein; Provisional	NA|395aa|down_8|NZ_CP023583.1_3959304_3960489_+	PRK08313, PRK08313, thiolase domain-containing protein	NA|344aa|down_9|NZ_CP023583.1_3960530_3961562_+	cd14952, NHL_PKND_like, NHL repeat domain of the protein kinase PknD
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	17	3998311-3998470	11	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	AACTCCGGCAGCGGCAATATCGGC	24	1	1	3998380-3998400	NZ_CP023583.1_430133-430113	NA	3	3	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|89aa|down_8|NZ_CP023583.1_4007942_4008209_-,NA|57aa|down_9|NZ_CP023583.1_4008239_4008410_-	NA|305aa|up_9|NZ_CP023583.1_3987157_3988072_-	PRK07791, PRK07791, short chain dehydrogenase; Provisional	NA|260aa|up_8|NZ_CP023583.1_3988094_3988874_-	PRK07856, PRK07856, SDR family oxidoreductase	NA|248aa|up_7|NZ_CP023583.1_3988928_3989672_+	PRK07938, PRK07938, enoyl-CoA hydratase family protein	NA|293aa|up_6|NZ_CP023583.1_3989671_3990550_+	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]	NA|251aa|up_5|NZ_CP023583.1_3990546_3991299_+	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]	NA|356aa|up_4|NZ_CP023583.1_3991396_3992464_+	pfam03060, NMO, Nitronate monooxygenase	NA|686aa|up_3|NZ_CP023583.1_3992460_3994518_+	TIGR02160, 12-phenylacetyl-CoA_epoxidase_subunit_E, phenylacetate-CoA oxygenase/reductase, PaaK subunit	NA|290aa|up_2|NZ_CP023583.1_3994605_3995475_-	pfam18741, MTES_1575, REase_MTES_1575	NA|387aa|up_1|NZ_CP023583.1_3995579_3996740_-	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase	NA|201aa|up_0|NZ_CP023583.1_3996804_3997407_-	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family	NA|263aa|down_0|NZ_CP023583.1_3999422_4000211_-	PRK07831, PRK07831, SDR family oxidoreductase	NA|386aa|down_1|NZ_CP023583.1_4000207_4001365_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|508aa|down_2|NZ_CP023583.1_4001412_4002936_+	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated	NA|378aa|down_3|NZ_CP023583.1_4002936_4004070_+	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|320aa|down_4|NZ_CP023583.1_4004066_4005026_+	cd00567, ACAD, Acyl-CoA dehydrogenase	NA|319aa|down_5|NZ_CP023583.1_4005022_4005979_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|389aa|down_6|NZ_CP023583.1_4005975_4007142_+	PRK05764, PRK05764, aspartate aminotransferase; Provisional	NA|284aa|down_7|NZ_CP023583.1_4007106_4007958_-	COG2162, NhoA, Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]	NA|89aa|down_8|NZ_CP023583.1_4007942_4008209_-	NA	NA|57aa|down_9|NZ_CP023583.1_4008239_4008410_-	NA
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	18	3998539-3998916	12	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	AACTCCGGCAGCGGCAATATCGGC	24	3	62	3998563-3998583|3998563-3998583|3998563-3998583|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998608-3998628|3998653-3998673|3998653-3998673|3998653-3998673|3998653-3998673	NZ_CP023583.1_427069-427049|NZ_CP023583.1_427099-427079|NZ_CP023583.1_431390-431370|NZ_CP023583.1_2922807-2922827|NZ_CP023583.1_132299-132319|NZ_CP023583.1_336647-336627|NZ_CP023583.1_528183-528163|NZ_CP023583.1_673088-673068|NZ_CP023583.1_673097-673077|NZ_CP023583.1_673148-673128|NZ_CP023583.1_673157-673137|NZ_CP023583.1_673268-673248|NZ_CP023583.1_673991-673971|NZ_CP023583.1_836862-836882|NZ_CP023583.1_837870-837890|NZ_CP023583.1_839318-839338|NZ_CP023583.1_840653-840673|NZ_CP023583.1_927961-927941|NZ_CP023583.1_968571-968551|NZ_CP023583.1_1091927-1091947|NZ_CP023583.1_1188464-1188444|NZ_CP023583.1_1188518-1188498|NZ_CP023583.1_1385161-1385141|NZ_CP023583.1_1618279-1618259|NZ_CP023583.1_1633018-1632998|NZ_CP023583.1_1991088-1991068|NZ_CP023583.1_2088480-2088460|NZ_CP023583.1_2088951-2088931|NZ_CP023583.1_2803299-2803279|NZ_CP023583.1_2922909-2922929|NZ_CP023583.1_2960085-2960065|NZ_CP023583.1_3737837-3737817|NZ_CP023583.1_3738426-3738406|NZ_CP023583.1_3738444-3738424|NZ_CP023583.1_3738495-3738475|NZ_CP023583.1_3738546-3738526|NZ_CP023583.1_3738690-3738670|NZ_CP023583.1_3739611-3739591|NZ_CP023583.1_3739788-3739768|NZ_CP023583.1_3740364-3740344|NZ_CP023583.1_3779674-3779694|NZ_CP023583.1_3926970-3926990|NZ_CP023583.1_3927066-3927086|NZ_CP023583.1_3928062-3928082|NZ_CP023583.1_3928071-3928091|NZ_CP023583.1_3928080-3928100|NZ_CP023583.1_3928089-3928109|NZ_CP023583.1_3928098-3928118|NZ_CP023583.1_3928851-3928871|NZ_CP023583.1_3929046-3929066|NZ_CP023583.1_3936160-3936180|NZ_CP023583.1_3941010-3941030|NZ_CP023583.1_3941346-3941366|NZ_CP023583.1_3941692-3941712|NZ_CP023583.1_3942334-3942354|NZ_CP023583.1_3943546-3943566|NZ_CP023583.1_3943663-3943683|NZ_CP023583.1_3944110-3944130|NZ_CP023583.1_1262679-1262659|NZ_CP023583.1_427069-427049|NZ_CP023583.1_427099-427079|NZ_CP023583.1_431390-431370	NA	6	6	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA,NA|89aa|down_8|NZ_CP023583.1_4007942_4008209_-,NA|57aa|down_9|NZ_CP023583.1_4008239_4008410_-	NA|305aa|up_9|NZ_CP023583.1_3987157_3988072_-	PRK07791, PRK07791, short chain dehydrogenase; Provisional	NA|260aa|up_8|NZ_CP023583.1_3988094_3988874_-	PRK07856, PRK07856, SDR family oxidoreductase	NA|248aa|up_7|NZ_CP023583.1_3988928_3989672_+	PRK07938, PRK07938, enoyl-CoA hydratase family protein	NA|293aa|up_6|NZ_CP023583.1_3989671_3990550_+	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]	NA|251aa|up_5|NZ_CP023583.1_3990546_3991299_+	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]	NA|356aa|up_4|NZ_CP023583.1_3991396_3992464_+	pfam03060, NMO, Nitronate monooxygenase	NA|686aa|up_3|NZ_CP023583.1_3992460_3994518_+	TIGR02160, 12-phenylacetyl-CoA_epoxidase_subunit_E, phenylacetate-CoA oxygenase/reductase, PaaK subunit	NA|290aa|up_2|NZ_CP023583.1_3994605_3995475_-	pfam18741, MTES_1575, REase_MTES_1575	NA|387aa|up_1|NZ_CP023583.1_3995579_3996740_-	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase	NA|201aa|up_0|NZ_CP023583.1_3996804_3997407_-	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family	NA|263aa|down_0|NZ_CP023583.1_3999422_4000211_-	PRK07831, PRK07831, SDR family oxidoreductase	NA|386aa|down_1|NZ_CP023583.1_4000207_4001365_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|508aa|down_2|NZ_CP023583.1_4001412_4002936_+	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated	NA|378aa|down_3|NZ_CP023583.1_4002936_4004070_+	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|320aa|down_4|NZ_CP023583.1_4004066_4005026_+	cd00567, ACAD, Acyl-CoA dehydrogenase	NA|319aa|down_5|NZ_CP023583.1_4005022_4005979_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|389aa|down_6|NZ_CP023583.1_4005975_4007142_+	PRK05764, PRK05764, aspartate aminotransferase; Provisional	NA|284aa|down_7|NZ_CP023583.1_4007106_4007958_-	COG2162, NhoA, Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]	NA|89aa|down_8|NZ_CP023583.1_4007942_4008209_-	NA	NA|57aa|down_9|NZ_CP023583.1_4008239_4008410_-	NA
GCF_002447075.1_ASM244707v1	NZ_CP023583	Mycobacterium tuberculosis strain MDRDM260 chromosome, complete genome	19	4110446-4110534	13	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,DEDDh,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	NA|257aa|up_8|NZ_CP023583.1_4101032_4101803_-,NA|119aa|up_3|NZ_CP023583.1_4106937_4107294_+,NA|52aa|up_2|NZ_CP023583.1_4107393_4107549_+,NA|233aa|up_0|NZ_CP023583.1_4109550_4110249_-,NA|126aa|down_5|NZ_CP023583.1_4115765_4116143_+	NA|288aa|up_9|NZ_CP023583.1_4099414_4100278_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023583.1_4101032_4101803_-	NA	NA|549aa|up_7|NZ_CP023583.1_4101799_4103446_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023583.1_4103442_4104306_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023583.1_4104298_4105225_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023583.1_4105226_4106852_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023583.1_4106937_4107294_+	NA	NA|52aa|up_2|NZ_CP023583.1_4107393_4107549_+	NA	NA|652aa|up_1|NZ_CP023583.1_4107559_4109515_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023583.1_4109550_4110249_-	NA	NA|173aa|down_0|NZ_CP023583.1_4110594_4111113_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023583.1_4111113_4112097_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023583.1_4112089_4113283_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|228aa|down_3|NZ_CP023583.1_4114237_4114921_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_4|NZ_CP023583.1_4114920_4115658_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_5|NZ_CP023583.1_4115765_4116143_+	NA	NA|225aa|down_6|NZ_CP023583.1_4116241_4116916_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_7|NZ_CP023583.1_4117021_4117816_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_8|NZ_CP023583.1_4117822_4118278_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function	NA|54aa|down_9|NZ_CP023583.1_4118293_4118455_-	pfam13783, DUF4177, Domain of unknown function (DUF4177)
