assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_001456065.2_ASM145606v2	NZ_CP013489	Clostridium butyricum strain KNU-L09 chromosome 2, complete sequence	1	222367-222478	1	CRISPRCasFinder	no		DEDDh,RT,csa3,cas2,cas1,cas4,cas3,cas5,cas6	Orphan	TTACTAAAATCACCGTTCGCAAGGGTAAAA	30	0	0	NA	NA	NA	1	1	Orphan	DinG,WYL,cas3,csx1,csa3,DEDDh,RT,cas2,cas1,cas4,cas5,cas6	NA|163aa|up_1|NZ_CP013489.1_219870_220359_+,NA|488aa|up_0|NZ_CP013489.1_220443_221907_-,NA|371aa|down_0|NZ_CP013489.1_222930_224043_+,NA|231aa|down_5|NZ_CP013489.1_230178_230871_+	NA|288aa|up_9|NZ_CP013489.1_212360_213224_-	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]	NA|182aa|up_8|NZ_CP013489.1_213284_213830_-	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones]	NA|159aa|up_7|NZ_CP013489.1_213885_214362_-	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate	NA|105aa|up_6|NZ_CP013489.1_214980_215295_-	PRK02898, PRK02898, energy-coupling factor ABC transporter substrate-binding protein	NA|249aa|up_5|NZ_CP013489.1_215296_216043_-	PRK08319, PRK08319, energy-coupling factor ABC transporter permease	NA|281aa|up_4|NZ_CP013489.1_216612_217455_-	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system	NA|257aa|up_3|NZ_CP013489.1_217464_218235_-	TIGR02454, Uncharacterized_protein_MJ1089, cobalt ECF transporter T component CbiQ	NA|308aa|up_2|NZ_CP013489.1_218495_219419_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|163aa|up_1|NZ_CP013489.1_219870_220359_+	NA	NA|488aa|up_0|NZ_CP013489.1_220443_221907_-	NA	NA|371aa|down_0|NZ_CP013489.1_222930_224043_+	NA	NA|318aa|down_1|NZ_CP013489.1_224996_225950_+	pfam00589, Phage_integrase, Phage integrase family	NA|336aa|down_2|NZ_CP013489.1_226098_227106_-	cd16408, ParB_N_like, ParB N-terminal, parA -binding, -like domain of bacterial and plasmid parABS partitioning systems	NA|325aa|down_3|NZ_CP013489.1_227214_228189_-	pfam13614, AAA_31, AAA domain	NA|384aa|down_4|NZ_CP013489.1_229023_230175_+	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins	NA|231aa|down_5|NZ_CP013489.1_230178_230871_+	NA	NA|170aa|down_6|NZ_CP013489.1_230941_231451_+	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|405aa|down_7|NZ_CP013489.1_231779_232994_-	COG0786, GltS, Na+/glutamate symporter [Amino acid transport and metabolism]	NA|637aa|down_8|NZ_CP013489.1_233987_235898_+	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed	NA|283aa|down_9|NZ_CP013489.1_236018_236867_-	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown]
GCF_001456065.2_ASM145606v2	NZ_CP013489	Clostridium butyricum strain KNU-L09 chromosome 2, complete sequence	2	222561-222651	2	CRISPRCasFinder	no		DEDDh,RT,csa3,cas2,cas1,cas4,cas3,cas5,cas6	Orphan	TTACTAAAATCACCGTTCGCAAGGGTAAAA	30	0	0	NA	NA	NA	1	1	Orphan	DinG,WYL,cas3,csx1,csa3,DEDDh,RT,cas2,cas1,cas4,cas5,cas6	NA|163aa|up_1|NZ_CP013489.1_219870_220359_+,NA|488aa|up_0|NZ_CP013489.1_220443_221907_-,NA|371aa|down_0|NZ_CP013489.1_222930_224043_+,NA|231aa|down_5|NZ_CP013489.1_230178_230871_+	NA|288aa|up_9|NZ_CP013489.1_212360_213224_-	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]	NA|182aa|up_8|NZ_CP013489.1_213284_213830_-	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones]	NA|159aa|up_7|NZ_CP013489.1_213885_214362_-	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate	NA|105aa|up_6|NZ_CP013489.1_214980_215295_-	PRK02898, PRK02898, energy-coupling factor ABC transporter substrate-binding protein	NA|249aa|up_5|NZ_CP013489.1_215296_216043_-	PRK08319, PRK08319, energy-coupling factor ABC transporter permease	NA|281aa|up_4|NZ_CP013489.1_216612_217455_-	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system	NA|257aa|up_3|NZ_CP013489.1_217464_218235_-	TIGR02454, Uncharacterized_protein_MJ1089, cobalt ECF transporter T component CbiQ	NA|308aa|up_2|NZ_CP013489.1_218495_219419_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|163aa|up_1|NZ_CP013489.1_219870_220359_+	NA	NA|488aa|up_0|NZ_CP013489.1_220443_221907_-	NA	NA|371aa|down_0|NZ_CP013489.1_222930_224043_+	NA	NA|318aa|down_1|NZ_CP013489.1_224996_225950_+	pfam00589, Phage_integrase, Phage integrase family	NA|336aa|down_2|NZ_CP013489.1_226098_227106_-	cd16408, ParB_N_like, ParB N-terminal, parA -binding, -like domain of bacterial and plasmid parABS partitioning systems	NA|325aa|down_3|NZ_CP013489.1_227214_228189_-	pfam13614, AAA_31, AAA domain	NA|384aa|down_4|NZ_CP013489.1_229023_230175_+	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins	NA|231aa|down_5|NZ_CP013489.1_230178_230871_+	NA	NA|170aa|down_6|NZ_CP013489.1_230941_231451_+	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|405aa|down_7|NZ_CP013489.1_231779_232994_-	COG0786, GltS, Na+/glutamate symporter [Amino acid transport and metabolism]	NA|637aa|down_8|NZ_CP013489.1_233987_235898_+	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed	NA|283aa|down_9|NZ_CP013489.1_236018_236867_-	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown]
GCF_001456065.2_ASM145606v2	NZ_CP013489	Clostridium butyricum strain KNU-L09 chromosome 2, complete sequence	3	781962-785715	1,3,1	PILER-CR,CRISPRCasFinder,CRT	no	cas2,cas1,cas4,cas3,cas5,cas6	DEDDh,RT,csa3,cas2,cas1,cas4,cas3,cas5,cas6	Unclear	ATTTAAATACATCTAATGTTACTGTTAATC,ATTTAAATACATCTAATGTTACTGTTAATC,ATTTAAATACATCTAATGTTACTGTTAATC	30,30,30	0	0	NA	NA	III-B:III-B:III-B	57,57,57	57	Unclear	DinG,WYL,cas3,csx1,csa3,DEDDh,RT,cas2,cas1,cas4,cas5,cas6	NA|113aa|up_9|NZ_CP013489.1_772571_772910_+,NA|80aa|up_6|NZ_CP013489.1_776076_776316_-,NA|108aa|up_2|NZ_CP013489.1_780231_780555_-,NA|211aa|up_1|NZ_CP013489.1_780547_781180_-,NA|128aa|up_0|NZ_CP013489.1_781185_781569_-,NA|100aa|down_8|NZ_CP013489.1_796120_796420_+	NA|113aa|up_9|NZ_CP013489.1_772571_772910_+	NA	NA|398aa|up_8|NZ_CP013489.1_773374_774568_-	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily	NA|394aa|up_7|NZ_CP013489.1_774811_775993_-	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]	NA|80aa|up_6|NZ_CP013489.1_776076_776316_-	NA	NA|292aa|up_5|NZ_CP013489.1_776522_777398_+	COG0583, LysR, Transcriptional regulator [Transcription]	NA|70aa|up_4|NZ_CP013489.1_777542_777752_-	pfam03994, DUF350, Domain of Unknown Function (DUF350)	NA|814aa|up_3|NZ_CP013489.1_777774_780216_-	pfam03738, GSP_synth, Glutathionylspermidine synthase preATP-grasp	NA|108aa|up_2|NZ_CP013489.1_780231_780555_-	NA	NA|211aa|up_1|NZ_CP013489.1_780547_781180_-	NA	NA|128aa|up_0|NZ_CP013489.1_781185_781569_-	NA	cas2|97aa|down_0|NZ_CP013489.1_785901_786192_-	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2	cas1|333aa|down_1|NZ_CP013489.1_786208_787207_-	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1	cas4|165aa|down_2|NZ_CP013489.1_787225_787720_-	pfam01930, Cas_Cas4, Domain of unknown function DUF83	cas3|872aa|down_3|NZ_CP013489.1_787770_790386_-	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3	cas5|266aa|down_4|NZ_CP013489.1_790436_791234_-	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI	cas6|231aa|down_5|NZ_CP013489.1_793960_794653_-	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6	NA|67aa|down_6|NZ_CP013489.1_794676_794877_-	pfam08011, PDDEXK_9, PD-(D/E)XK nuclease superfamily	NA|342aa|down_7|NZ_CP013489.1_794986_796011_+	COG3677, COG3677, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|100aa|down_8|NZ_CP013489.1_796120_796420_+	NA	NA|273aa|down_9|NZ_CP013489.1_796581_797400_-	pfam12787, EcsC, EcsC protein family
GCF_001456065.2_ASM145606v2	NZ_CP013252	Clostridium butyricum strain KNU-L09 chromosome 1, complete sequence	1	2117132-2117215	1	CRISPRCasFinder	no		DinG,WYL,cas3,csx1,csa3,DEDDh,RT	Orphan	TGGTATTATCTAAATGAAGATGGA	24	0	0	NA	NA	NA	1	1	Orphan	DinG,WYL,cas3,csx1,csa3,DEDDh,RT,cas2,cas1,cas4,cas5,cas6	NA,NA	NA|195aa|up_9|NZ_CP013252.1_2101773_2102358_-	COG2112, COG2112, Predicted Ser/Thr protein kinase [Signal transduction mechanisms]	NA|460aa|up_8|NZ_CP013252.1_2102629_2104009_+	PRK09496, trkA, Trk system potassium transporter TrkA	NA|483aa|up_7|NZ_CP013252.1_2103998_2105447_+	COG0168, TrkG, Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]	NA|239aa|up_6|NZ_CP013252.1_2105618_2106335_+	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]	NA|299aa|up_5|NZ_CP013252.1_2106503_2107400_+	COG1737, RpiR, Transcriptional regulators [Transcription]	NA|439aa|up_4|NZ_CP013252.1_2107489_2108806_+	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional	NA|88aa|up_3|NZ_CP013252.1_2108961_2109225_+	pfam10719, ComFB, Late competence development protein ComFB	NA|679aa|up_2|NZ_CP013252.1_2109385_2111422_+	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]	NA|1076aa|up_1|NZ_CP013252.1_2111741_2114969_+	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|457aa|up_0|NZ_CP013252.1_2115038_2116409_-	TIGR04105, hypothetical_protein, [FeFe] hydrogenase, group B1/B3	NA|466aa|down_0|NZ_CP013252.1_2117720_2119118_+	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD	NA|201aa|down_1|NZ_CP013252.1_2119181_2119784_-	smart00257, LysM, Lysin motif	NA|166aa|down_2|NZ_CP013252.1_2120047_2120545_+	COG1329, COG1329, Transcriptional regulators, similar to M	NA|309aa|down_3|NZ_CP013252.1_2120682_2121609_+	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein	NA|307aa|down_4|NZ_CP013252.1_2121653_2122574_-	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter	NA|204aa|down_5|NZ_CP013252.1_2122734_2123346_-	COG1971, COG1971, Predicted membrane protein [Function unknown]	NA|556aa|down_6|NZ_CP013252.1_2123722_2125390_+	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated	NA|354aa|down_7|NZ_CP013252.1_2125475_2126537_+	PRK05387, PRK05387, histidinol-phosphate aminotransferase; Provisional	NA|511aa|down_8|NZ_CP013252.1_2126682_2128215_+	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|460aa|down_9|NZ_CP013252.1_2128239_2129619_-	pfam13586, DDE_Tnp_1_2, Transposase DDE domain
GCF_001456065.2_ASM145606v2	NZ_CP013252	Clostridium butyricum strain KNU-L09 chromosome 1, complete sequence	2	3558208-3558293	2	CRISPRCasFinder	no		DinG,WYL,cas3,csx1,csa3,DEDDh,RT	Orphan	TCTTTCCCAAGATAATATTTAAA	23	0	0	NA	NA	NA	1	1	Orphan	DinG,WYL,cas3,csx1,csa3,DEDDh,RT,cas2,cas1,cas4,cas5,cas6	NA|1047aa|up_7|NZ_CP013252.1_3546610_3549751_-,NA|112aa|up_2|NZ_CP013252.1_3555167_3555503_-,NA|132aa|up_1|NZ_CP013252.1_3555504_3555900_-,NA|109aa|down_6|NZ_CP013252.1_3564896_3565223_-	NA|338aa|up_9|NZ_CP013252.1_3543984_3544998_-	COG1609, PurR, Transcriptional regulators [Transcription]	NA|448aa|up_8|NZ_CP013252.1_3545249_3546593_-	pfam02055, Glyco_hydro_30, Glycosyl hydrolase family 30 TIM-barrel domain	NA|1047aa|up_7|NZ_CP013252.1_3546610_3549751_-	NA	NA|276aa|up_6|NZ_CP013252.1_3549920_3550748_-	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]	NA|300aa|up_5|NZ_CP013252.1_3550747_3551647_-	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]	NA|445aa|up_4|NZ_CP013252.1_3551856_3553191_-	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold	NA|476aa|up_3|NZ_CP013252.1_3553659_3555087_-	PRK09589, celA, 6-phospho-beta-glucosidase; Reviewed	NA|112aa|up_2|NZ_CP013252.1_3555167_3555503_-	NA	NA|132aa|up_1|NZ_CP013252.1_3555504_3555900_-	NA	NA|587aa|up_0|NZ_CP013252.1_3556349_3558110_+	PRK12315, PRK12315, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional	NA|528aa|down_0|NZ_CP013252.1_3558295_3559879_-	cd13609, PBP2_Opu_like_1, Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 periplasmic-binding protein fold	NA|376aa|down_1|NZ_CP013252.1_3559878_3561006_-	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]	NA|210aa|down_2|NZ_CP013252.1_3561149_3561779_+	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]	NA|241aa|down_3|NZ_CP013252.1_3561915_3562638_-	pfam14417, MEDS, MEDS: MEthanogen/methylotroph, DcmR Sensory domain	NA|113aa|down_4|NZ_CP013252.1_3562875_3563214_-	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism]	NA|526aa|down_5|NZ_CP013252.1_3563258_3564836_-	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism]	NA|109aa|down_6|NZ_CP013252.1_3564896_3565223_-	NA	NA|471aa|down_7|NZ_CP013252.1_3565608_3567021_-	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism]	NA|489aa|down_8|NZ_CP013252.1_3567463_3568930_+	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|413aa|down_9|NZ_CP013252.1_3569194_3570433_-	pfam00872, Transposase_mut, Transposase, Mutator family
GCF_001456065.2_ASM145606v2	NZ_CP013252	Clostridium butyricum strain KNU-L09 chromosome 1, complete sequence	3	3613971-3614059	3	CRISPRCasFinder	no		DinG,WYL,cas3,csx1,csa3,DEDDh,RT	Orphan	TGTTAATATTATTACATTTGTAGTTA	26	0	0	NA	NA	NA	1	1	Orphan	DinG,WYL,cas3,csx1,csa3,DEDDh,RT,cas2,cas1,cas4,cas5,cas6	NA|133aa|up_4|NZ_CP013252.1_3604433_3604832_-,NA	NA|233aa|up_9|NZ_CP013252.1_3594738_3595437_-	COG4750, LicC, CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes [Cell envelope biogenesis, outer membrane]	NA|617aa|up_8|NZ_CP013252.1_3595628_3597479_-	cd05151, ChoK-like, Choline Kinase and similar proteins	NA|331aa|up_7|NZ_CP013252.1_3598087_3599080_-	COG3677, COG3677, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|420aa|up_6|NZ_CP013252.1_3599646_3600906_+	pfam13546, DDE_5, DDE superfamily endonuclease	NA|1024aa|up_5|NZ_CP013252.1_3600961_3604033_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|133aa|up_4|NZ_CP013252.1_3604433_3604832_-	NA	NA|671aa|up_3|NZ_CP013252.1_3605174_3607187_-	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3	NA|747aa|up_2|NZ_CP013252.1_3607841_3610082_-	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3	NA|532aa|up_1|NZ_CP013252.1_3610266_3611862_-	PRK00741, prfC, peptide chain release factor 3; Provisional	NA|350aa|up_0|NZ_CP013252.1_3612907_3613957_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|1006aa|down_0|NZ_CP013252.1_3614168_3617186_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|548aa|down_1|NZ_CP013252.1_3617831_3619475_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|331aa|down_2|NZ_CP013252.1_3620066_3621059_-	COG3677, COG3677, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|746aa|down_3|NZ_CP013252.1_3621552_3623790_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|326aa|down_4|NZ_CP013252.1_3624312_3625290_-	cd01536, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily	NA|669aa|down_5|NZ_CP013252.1_3625304_3627311_-	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]	NA|506aa|down_6|NZ_CP013252.1_3627779_3629297_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|594aa|down_7|NZ_CP013252.1_3629734_3631516_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|321aa|down_8|NZ_CP013252.1_3632147_3633110_-	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only]	NA|470aa|down_9|NZ_CP013252.1_3633116_3634526_-	PRK08581, PRK08581, amidase domain-containing protein
