assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_000307535.1_ASM30753v1	NC_018936	Streptococcus pyogenes A20, complete genome	1	778106-778339	1,1,1	PILER-CR,CRISPRCasFinder,CRT	no	cas9,cas1,cas2,csn2	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	Type II-A,Type II-B,Type II-C	GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC,GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC,GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	36,36,36	0	0	NA	NA	II-A:II-A:II-A	2,3,3	3	TypeII-A,TypeII-B,TypeII-C	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	NA|214aa|up_8|NC_018936.1_767565_768207_+,NA	NA|452aa|up_9|NC_018936.1_766076_767432_+	PRK14316, glmM, phosphoglucosamine mutase; Provisional	NA|214aa|up_8|NC_018936.1_767565_768207_+	NA	NA|377aa|up_7|NC_018936.1_768269_769400_+	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase	NA|251aa|up_6|NC_018936.1_769409_770162_+	COG3884, FatA, Acyl-ACP thioesterase [Lipid metabolism]	NA|255aa|up_5|NC_018936.1_770161_770926_+	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase	NA|211aa|up_4|NC_018936.1_770925_771558_+	COG4478, COG4478, Predicted membrane protein [Function unknown]	cas9|1369aa|up_3|NC_018936.1_772037_776144_+	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]	cas1|290aa|up_2|NC_018936.1_776143_777013_+	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1	cas2|114aa|up_1|NC_018936.1_777009_777351_+	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms]	csn2|221aa|up_0|NC_018936.1_777340_778003_+	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2	NA|60aa|down_0|NC_018936.1_778469_778649_+	cd04413, NDPk_I, Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate	NA|49aa|down_1|NC_018936.1_778712_778859_+	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated	NA|611aa|down_2|NC_018936.1_778982_780815_+	PRK05433, PRK05433, GTP-binding protein LepA; Provisional	NA|294aa|down_3|NC_018936.1_781072_781954_+	pfam00746, Gram_pos_anchor, LPXTG cell wall anchor motif	NA|146aa|down_4|NC_018936.1_782139_782577_+	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB	NA|340aa|down_5|NC_018936.1_782691_783711_+	COG2855, COG2855, Predicted membrane protein [Function unknown]	NA|142aa|down_6|NC_018936.1_783917_784343_+	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism]	NA|164aa|down_7|NC_018936.1_784361_784853_+	COG3444, COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB [Carbohydrate transport and metabolism]	NA|270aa|down_8|NC_018936.1_784869_785679_+	COG3715, ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]	NA|276aa|down_9|NC_018936.1_785675_786503_+	COG3716, ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]
GCF_000307535.1_ASM30753v1	NC_018936	Streptococcus pyogenes A20, complete genome	2	972576-972677	2	CRISPRCasFinder	no		cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	Orphan	AATAATTGGTATAGTCTAATTATA	24	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	NA,NA|262aa|down_6|NC_018936.1_980507_981293_+,NA|63aa|down_8|NC_018936.1_982624_982813_-	NA|83aa|up_9|NC_018936.1_960293_960542_-	COG2261, COG2261, Predicted membrane protein [Function unknown]	NA|773aa|up_8|NC_018936.1_960905_963224_-	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA	NA|441aa|up_7|NC_018936.1_963752_965075_+	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism]	NA|412aa|up_6|NC_018936.1_965194_966430_+	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]	NA|258aa|up_5|NC_018936.1_966798_967572_-	pfam07373, CAMP_factor, CAMP factor (Cfa)	NA|279aa|up_4|NC_018936.1_967941_968778_-	cd00996, PBP2_AatB_like, Polar amino acids-binding domain of ATP-binding cassette transporter-like systems that belong to the type 2 periplasmic binding fold protein superfamily	NA|210aa|up_3|NC_018936.1_968793_969423_-	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]	NA|214aa|up_2|NC_018936.1_969432_970074_-	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]	NA|112aa|up_1|NC_018936.1_970179_970515_-	COG2824, PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]	NA|605aa|up_0|NC_018936.1_970710_972525_-	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase	NA|186aa|down_0|NC_018936.1_972700_973258_-	TIGR02227, Inactive_signal_peptidase_IA	NA|501aa|down_1|NC_018936.1_973475_974978_-	PRK05826, PRK05826, pyruvate kinase; Provisional	NA|338aa|down_2|NC_018936.1_975040_976054_-	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase	NA|1037aa|down_3|NC_018936.1_976133_979244_-	PRK07279, dnaE, DNA polymerase III DnaE; Reviewed	NA|124aa|down_4|NC_018936.1_979428_979800_+	COG1725, COG1725, Predicted transcriptional regulators [Transcription]	NA|233aa|down_5|NC_018936.1_979799_980498_+	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms]	NA|262aa|down_6|NC_018936.1_980507_981293_+	NA	NA|205aa|down_7|NC_018936.1_981419_982034_-	COG0398, COG0398, Uncharacterized conserved protein [Function unknown]	NA|63aa|down_8|NC_018936.1_982624_982813_-	NA	NA|252aa|down_9|NC_018936.1_983032_983788_+	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain
GCF_000307535.1_ASM30753v1	NC_018936	Streptococcus pyogenes A20, complete genome	3	1078171-1078306	3	CRISPRCasFinder	no		cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	Orphan	CAGCTTCTTCTGATTGTAAAGCGTCTGTTTGATCCGCCAATGCTTCTAAGGC	52	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	NA,NA	NA|134aa|up_9|NC_018936.1_1067739_1068141_-	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|205aa|up_8|NC_018936.1_1068225_1068840_-	cd09007, NP-I_spr0068, uncharacterized subfamily of the nucleoside phosphorylase-I family	NA|463aa|up_7|NC_018936.1_1069042_1070431_-	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]	NA|484aa|up_6|NC_018936.1_1070479_1071931_-	COG1316, LytR, Transcriptional regulator [Transcription]	NA|164aa|up_5|NC_018936.1_1072138_1072630_-	PRK00131, aroK, shikimate kinase; Reviewed	NA|431aa|up_4|NC_018936.1_1072622_1073915_-	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional	NA|322aa|up_3|NC_018936.1_1074016_1074982_-	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair]	NA|287aa|up_2|NC_018936.1_1074983_1075844_-	PRK07281, PRK07281, methionyl aminopeptidase	NA|428aa|up_1|NC_018936.1_1075859_1077143_-	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription]	NA|181aa|up_0|NC_018936.1_1077151_1077694_-	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]	NA|420aa|down_0|NC_018936.1_1078942_1080202_-	PRK12830, PRK12830, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed	NA|399aa|down_1|NC_018936.1_1080375_1081572_-	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|793aa|down_2|NC_018936.1_1082108_1084487_-	COG4886, COG4886, Leucine-rich repeat (LRR) protein [Function unknown]	NA|314aa|down_3|NC_018936.1_1084690_1085632_+	PRK11886, PRK11886, bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	NA|91aa|down_4|NC_018936.1_1085606_1085879_-	pfam11676, DUF3272, Protein of unknown function (DUF3272)	NA|557aa|down_5|NC_018936.1_1085904_1087575_-	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated	NA|166aa|down_6|NC_018936.1_1087574_1088072_-	COG1956, COG1956, GAF domain-containing protein [Signal transduction mechanisms]	NA|270aa|down_7|NC_018936.1_1088216_1089026_+	COG2339, prsW, Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]	NA|88aa|down_8|NC_018936.1_1089078_1089342_-	COG3326, COG3326, Predicted membrane protein [Function unknown]	NA|209aa|down_9|NC_018936.1_1089421_1090048_-	PRK05480, PRK05480, uridine/cytidine kinase; Provisional
GCF_000307535.1_ASM30753v1	NC_018936	Streptococcus pyogenes A20, complete genome	4	1238426-1238720	4,2,2	CRISPRCasFinder,CRT,PILER-CR	no	cas2,cas1,cas4,cas7,cas8c,cas5,cas3	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	Type I-U,Type I-C, Type I-U?	ATTTCAATCCACTCACCCATGAAGGGTGAGAC,ATTTCAATCCACTCACCCATGAAGGGTGAGAC,TTTCAATCCACTCACCCATGAAGGGTGAGAC	32,32,31	0	0	NA	NA	I-C:I-C:I-C	4,4,4	4	TypeI-C,TypeI-U,TypeI-U?	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	NA,NA	NA|412aa|up_9|NC_018936.1_1228360_1229596_-	PRK01388, PRK01388, arginine deiminase; Provisional	NA|227aa|up_8|NC_018936.1_1229869_1230550_-	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|158aa|up_7|NC_018936.1_1230691_1231165_+	COG1438, ArgR, Arginine repressor [Transcription]	NA|239aa|up_6|NC_018936.1_1231330_1232047_-	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]	NA|360aa|up_5|NC_018936.1_1232060_1233140_-	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown]	NA|578aa|up_4|NC_018936.1_1233212_1234946_-	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]	NA|247aa|up_3|NC_018936.1_1234942_1235683_-	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]	NA|369aa|up_2|NC_018936.1_1235770_1236877_-	PRK14018, PRK14018, bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB	NA|208aa|up_1|NC_018936.1_1236919_1237543_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|237aa|up_0|NC_018936.1_1237555_1238266_-	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]	cas2|98aa|down_0|NC_018936.1_1238868_1239162_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|342aa|down_1|NC_018936.1_1239172_1240198_-	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG	cas4|225aa|down_2|NC_018936.1_1240194_1240869_-	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense    mechanisms]	cas7|283aa|down_3|NC_018936.1_1240870_1241719_-	COG3649, COG3649, CRISPR system related protein [Defense mechanisms]	cas8c|632aa|down_4|NC_018936.1_1241723_1243619_-	cd09642, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c	cas5|243aa|down_5|NC_018936.1_1243618_1244347_-	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG	cas3|803aa|down_6|NC_018936.1_1244479_1246888_-	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms]	NA|883aa|down_7|NC_018936.1_1247041_1249690_-	PRK05729, valS, valyl-tRNA synthetase; Reviewed	NA|188aa|down_8|NC_018936.1_1249691_1250255_-	pfam13238, AAA_18, AAA domain	NA|67aa|down_9|NC_018936.1_1250251_1250452_-	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]
GCF_000307535.1_ASM30753v1	NC_018936	Streptococcus pyogenes A20, complete genome	5	1683021-1683154	5	CRISPRCasFinder	no		cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	Orphan	TGGTCTATCGCTAATTCAAGAGCTTTCTTTTTCTCTTCTAACTCTTTTTC	50	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,DEDDh,csa3	NA,NA|84aa|down_1|NC_018936.1_1686002_1686254_-,NA|135aa|down_8|NC_018936.1_1693749_1694154_-	NA|274aa|up_9|NC_018936.1_1666424_1667246_+	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|268aa|up_8|NC_018936.1_1667257_1668061_+	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|209aa|up_7|NC_018936.1_1668044_1668671_+	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|67aa|up_6|NC_018936.1_1668751_1668952_-	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown]	NA|826aa|up_5|NC_018936.1_1669120_1671598_-	TIGR01363, pneumococcal_histidine_triad_A_protein, streptococcal histidine triad protein	NA|307aa|up_4|NC_018936.1_1671610_1672531_-	cd01017, AdcA, Metal binding protein AdcA	NA|378aa|up_3|NC_018936.1_1672708_1673842_-	COG5433, COG5433, Transposase [DNA replication, recombination, and repair]	NA|356aa|up_2|NC_018936.1_1674092_1675160_-	TIGR01168, M_protein_serotype, Gram-positive signal peptide, YSIRK family	NA|1165aa|up_1|NC_018936.1_1675256_1678751_-	cd07475, Peptidases_S8_C5a_Peptidase, Peptidase S8 family domain in Streptococcal C5a peptidases	NA|314aa|up_0|NC_018936.1_1680968_1681910_-	pfam03482, SIC, sic protein repeat	NA|530aa|down_0|NC_018936.1_1683737_1685327_-	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain	NA|84aa|down_1|NC_018936.1_1686002_1686254_-	NA	NA|534aa|down_2|NC_018936.1_1686332_1687934_-	COG3942, COG3942, Surface antigen [General function prediction only]	NA|463aa|down_3|NC_018936.1_1688035_1689424_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|218aa|down_4|NC_018936.1_1689420_1690074_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|406aa|down_5|NC_018936.1_1690167_1691385_-	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB	NA|225aa|down_6|NC_018936.1_1691397_1692072_-	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]	NA|423aa|down_7|NC_018936.1_1692058_1693327_-	COG0845, AcrA, Membrane-fusion protein [Cell envelope biogenesis, outer membrane]	NA|135aa|down_8|NC_018936.1_1693749_1694154_-	NA	NA|99aa|down_9|NC_018936.1_1694180_1694477_-	pfam14131, DUF4298, Domain of unknown function (DUF4298)
