assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	1	335451-335549	1	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	CGCAGTCCGGTGGCGGACAGGCAG	24	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|52aa|up_8|NC_013093.1_328006_328162_+,NA	NA|273aa|up_9|NC_013093.1_326737_327556_-	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]	NA|52aa|up_8|NC_013093.1_328006_328162_+	NA	NA|320aa|up_7|NC_013093.1_328148_329108_-	TIGR03617, F420_MSMEG_2256, probable F420-dependent oxidoreductase, MSMEG_2256 family	NA|131aa|up_6|NC_013093.1_329239_329632_-	pfam05901, Excalibur, Excalibur calcium-binding domain	NA|252aa|up_5|NC_013093.1_329693_330449_-	pfam05901, Excalibur, Excalibur calcium-binding domain	NA|224aa|up_4|NC_013093.1_330649_331321_-	smart00318, SNc, Staphylococcal nuclease homologues	NA|149aa|up_3|NC_013093.1_331442_331889_-	pfam14539, DUF4442, Domain of unknown function (DUF4442)	NA|173aa|up_2|NC_013093.1_332018_332537_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|556aa|up_1|NC_013093.1_332536_334204_+	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily	NA|168aa|up_0|NC_013093.1_334312_334816_-	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase	NA|341aa|down_0|NC_013093.1_338022_339045_+	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated	NA|309aa|down_1|NC_013093.1_339041_339968_+	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]	NA|183aa|down_2|NC_013093.1_339984_340533_+	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]	NA|565aa|down_3|NC_013093.1_340596_342291_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|744aa|down_4|NC_013093.1_342756_344988_+	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH	NA|210aa|down_5|NC_013093.1_344984_345614_+	PRK09347, folE, GTP cyclohydrolase I; Provisional	NA|262aa|down_6|NC_013093.1_345652_346438_+	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes	NA|126aa|down_7|NC_013093.1_346430_346808_+	pfam02152, FolB, Dihydroneopterin aldolase	NA|159aa|down_8|NC_013093.1_346804_347281_+	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]	NA|151aa|down_9|NC_013093.1_347277_347730_+	pfam11377, DUF3180, Protein of unknown function (DUF3180)
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	2	502528-502648	1	PILER-CR	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	TGCCGTCGAGCAGGTCGTCCAGGTC	25	0	0	NA	NA	NA	2	2	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|177aa|up_7|NC_013093.1_492342_492873_+,NA|153aa|up_6|NC_013093.1_492928_493387_+,NA|62aa|down_1|NC_013093.1_505349_505535_+	NA|313aa|up_9|NC_013093.1_489426_490365_+	PRK02901, PRK02901, O-succinylbenzoate synthase; Provisional	NA|551aa|up_8|NC_013093.1_490564_492217_-	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]	NA|177aa|up_7|NC_013093.1_492342_492873_+	NA	NA|153aa|up_6|NC_013093.1_492928_493387_+	NA	NA|363aa|up_5|NC_013093.1_493477_494566_+	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated	NA|334aa|up_4|NC_013093.1_494630_495632_-	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]	NA|1116aa|up_3|NC_013093.1_495972_499320_+	pfam08376, NIT, Nitrate and nitrite sensing	NA|140aa|up_2|NC_013093.1_499316_499736_+	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]	NA|249aa|up_1|NC_013093.1_499763_500510_+	pfam05331, DUF742, Protein of unknown function (DUF742)	NA|203aa|up_0|NC_013093.1_500490_501099_+	COG2229, COG2229, Predicted GTPase [General function prediction only]	NA|748aa|down_0|NC_013093.1_503040_505284_-	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain	NA|62aa|down_1|NC_013093.1_505349_505535_+	NA	NA|468aa|down_2|NC_013093.1_505640_507044_+	COG0281, SfcA, Malic enzyme [Energy production and conversion]	NA|158aa|down_3|NC_013093.1_507284_507758_+	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC	NA|153aa|down_4|NC_013093.1_507778_508237_+	cd00886, MogA_MoaB, MogA_MoaB family	NA|142aa|down_5|NC_013093.1_508233_508659_+	cd00756, MoaE, MoaE family	NA|225aa|down_6|NC_013093.1_509100_509775_-	pfam06737, Transglycosylas, Transglycosylase-like domain	NA|88aa|down_7|NC_013093.1_510137_510401_-	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins	NA|352aa|down_8|NC_013093.1_510402_511458_-	PRK00164, moaA, GTP 3',8-cyclase MoaA	NA|154aa|down_9|NC_013093.1_511562_512024_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	3	919049-919125	2	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	GCGGTCGCCCCGGTGACCCCCGCG	24	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA,NA|97aa|down_5|NC_013093.1_925943_926234_-,NA|152aa|down_6|NC_013093.1_926721_927177_-,NA|116aa|down_9|NC_013093.1_929343_929691_-	NA|131aa|up_9|NC_013093.1_907307_907700_-	pfam16170, DUF4873, Domain of unknown function (DUF4873)	NA|276aa|up_8|NC_013093.1_907696_908524_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|300aa|up_7|NC_013093.1_908585_909485_+	pfam11583, AurF, P-aminobenzoate N-oxygenase AurF	NA|215aa|up_6|NC_013093.1_909526_910171_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|373aa|up_5|NC_013093.1_910198_911317_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|345aa|up_4|NC_013093.1_911387_912422_+	pfam11350, DUF3152, Protein of unknown function (DUF3152)	NA|391aa|up_3|NC_013093.1_912540_913713_+	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated	NA|266aa|up_2|NC_013093.1_914317_915115_+	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein	NA|664aa|up_1|NC_013093.1_915289_917281_+	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite	NA|486aa|up_0|NC_013093.1_917525_918983_+	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion]	NA|451aa|down_0|NC_013093.1_919253_920606_+	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism]	NA|835aa|down_1|NC_013093.1_920981_923486_+	PRK14989, PRK14989, nitrite reductase subunit NirD; Provisional	NA|137aa|down_2|NC_013093.1_923482_923893_+	cd03529, Rieske_NirD, Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium	NA|382aa|down_3|NC_013093.1_923931_925077_+	PRK07239, PRK07239, bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated	NA|247aa|down_4|NC_013093.1_925091_925832_+	cd03416, CbiX_SirB_N, Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain	NA|97aa|down_5|NC_013093.1_925943_926234_-	NA	NA|152aa|down_6|NC_013093.1_926721_927177_-	NA	NA|229aa|down_7|NC_013093.1_927293_927980_+	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|457aa|down_8|NC_013093.1_927976_929347_+	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|116aa|down_9|NC_013093.1_929343_929691_-	NA
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	4	1868160-1868239	3	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	GACCGCGGCGCGCGGAACGGCCCCGG	26	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|204aa|up_6|NC_013093.1_1860532_1861144_+,NA|126aa|up_1|NC_013093.1_1865826_1866204_+,NA|92aa|down_4|NC_013093.1_1876295_1876571_-,NA|397aa|down_8|NC_013093.1_1881655_1882846_+	NA|282aa|up_9|NC_013093.1_1857402_1858248_-	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases	NA|283aa|up_8|NC_013093.1_1858319_1859168_+	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain	NA|422aa|up_7|NC_013093.1_1859177_1860443_+	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed	NA|204aa|up_6|NC_013093.1_1860532_1861144_+	NA	NA|288aa|up_5|NC_013093.1_1862024_1862888_-	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism]	NA|121aa|up_4|NC_013093.1_1862973_1863336_+	pfam06993, DUF1304, Protein of unknown function (DUF1304)	NA|514aa|up_3|NC_013093.1_1863262_1864804_-	pfam07907, YibE_F, YibE/F-like protein	NA|290aa|up_2|NC_013093.1_1864843_1865713_+	smart00306, HintN, Hint (Hedgehog/Intein) domain N-terminal region	NA|126aa|up_1|NC_013093.1_1865826_1866204_+	NA	NA|196aa|up_0|NC_013093.1_1866344_1866932_+	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family	NA|532aa|down_0|NC_013093.1_1869962_1871558_+	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain	NA|677aa|down_1|NC_013093.1_1871565_1873596_+	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]	NA|387aa|down_2|NC_013093.1_1873592_1874753_+	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism]	NA|323aa|down_3|NC_013093.1_1874793_1875762_-	PRK13355, PRK13355, bifunctional HTH-domain containing protein/aminotransferase; Provisional	NA|92aa|down_4|NC_013093.1_1876295_1876571_-	NA	NA|382aa|down_5|NC_013093.1_1876597_1877743_+	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins	NA|398aa|down_6|NC_013093.1_1878009_1879203_+	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins	NA|593aa|down_7|NC_013093.1_1879377_1881156_+	PRK00476, aspS, aspartyl-tRNA synthetase; Validated	NA|397aa|down_8|NC_013093.1_1881655_1882846_+	NA	NA|425aa|down_9|NC_013093.1_1883099_1884374_-	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	5	2530584-2530691	4	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	GCCGCCGTGCCCGTGCCGCCGCGC	24	1	1	2530650-2530667	NC_013093.1_5836726-5836743	NA	2	2	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|165aa|up_8|NC_013093.1_2519122_2519617_-,NA|74aa|up_2|NC_013093.1_2525811_2526033_-,NA|677aa|down_0|NC_013093.1_2530760_2532791_-	NA|294aa|up_9|NC_013093.1_2517943_2518825_+	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter	NA|165aa|up_8|NC_013093.1_2519122_2519617_-	NA	NA|181aa|up_7|NC_013093.1_2520092_2520635_-	pfam04264, YceI, YceI-like domain	NA|167aa|up_6|NC_013093.1_2520728_2521229_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|324aa|up_5|NC_013093.1_2521577_2522549_+	COG0714, COG0714, MoxR-like ATPases [General function prediction only]	NA|356aa|up_4|NC_013093.1_2522602_2523670_+	pfam01882, DUF58, Protein of unknown function DUF58	NA|556aa|up_3|NC_013093.1_2523841_2525509_+	cd05974, MACS_like_1, Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS)	NA|74aa|up_2|NC_013093.1_2525811_2526033_-	NA	NA|1085aa|up_1|NC_013093.1_2526280_2529535_+	cd03678, MM_CoA_mutase_1, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain	NA|295aa|up_0|NC_013093.1_2529640_2530525_+	sd00006, TPR, Tetratricopeptide repeat	NA|677aa|down_0|NC_013093.1_2530760_2532791_-	NA	NA|681aa|down_1|NC_013093.1_2533374_2535417_+	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed	NA|1144aa|down_2|NC_013093.1_2535437_2538869_+	PRK05561, PRK05561, DNA topoisomerase 4 subunit A	NA|237aa|down_3|NC_013093.1_2539015_2539726_+	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]	NA|186aa|down_4|NC_013093.1_2539802_2540360_+	pfam14124, DUF4291, Domain of unknown function (DUF4291)	NA|383aa|down_5|NC_013093.1_2540483_2541632_+	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family	NA|198aa|down_6|NC_013093.1_2541628_2542222_+	TIGR04037, predicted_flavoprotein, LLM-partnered FMN reductase, CE1759 family	NA|288aa|down_7|NC_013093.1_2542608_2543472_+	PRK00489, hisG, ATP phosphoribosyltransferase; Reviewed	NA|813aa|down_8|NC_013093.1_2543823_2546262_-	COG5001, COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]	NA|164aa|down_9|NC_013093.1_2546956_2547448_+	cd08895, SRPBCC_CalC_Aha1-like_2, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	6	6198106-6198212	5	CRISPRCasFinder	no	WYL	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Unclear	CGGGAGCGCGGACTGCGGGCCGG	23	2	2	6198129-6198147|6198171-6198189	NC_013093.1_3311843-3311861|NC_013093.1_783172-783154	NA	2	2	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA,NA|164aa|down_6|NC_013093.1_6205918_6206410_-,NA|166aa|down_8|NC_013093.1_6208246_6208744_+	NA|260aa|up_9|NC_013093.1_6186628_6187408_+	pfam01182, Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	NA|390aa|up_8|NC_013093.1_6188025_6189195_+	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|442aa|up_7|NC_013093.1_6189581_6190907_-	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated	NA|314aa|up_6|NC_013093.1_6190951_6191893_+	COG3889, COG3889, Predicted solute binding protein [General function prediction only]	NA|115aa|up_5|NC_013093.1_6191976_6192321_-	pfam13397, RbpA, RNA polymerase-binding protein	NA|78aa|up_4|NC_013093.1_6192372_6192606_-	PRK06870, secG, preprotein translocase subunit SecG; Reviewed	NA|262aa|up_3|NC_013093.1_6192699_6193485_-	PRK00042, tpiA, triosephosphate isomerase; Provisional	NA|389aa|up_2|NC_013093.1_6193486_6194653_-	PRK00073, pgk, phosphoglycerate kinase; Provisional	NA|335aa|up_1|NC_013093.1_6194672_6195677_-	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]	NA|327aa|up_0|NC_013093.1_6196042_6197023_-	pfam09770, PAT1, Topoisomerase II-associated protein PAT1	NA|329aa|down_0|NC_013093.1_6198661_6199648_-	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA	NA|351aa|down_1|NC_013093.1_6199638_6200691_-	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related	NA|286aa|down_2|NC_013093.1_6200687_6201545_-	PRK05416, PRK05416, RNase adapter RapZ	NA|650aa|down_3|NC_013093.1_6201571_6203521_-	PRK00558, uvrC, excinuclease ABC subunit UvrC	NA|172aa|down_4|NC_013093.1_6203862_6204378_-	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes	NA|137aa|down_5|NC_013093.1_6204628_6205039_-	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes	NA|164aa|down_6|NC_013093.1_6205918_6206410_-	NA	NA|519aa|down_7|NC_013093.1_6206690_6208247_+	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|166aa|down_8|NC_013093.1_6208246_6208744_+	NA	WYL|318aa|down_9|NC_013093.1_6208807_6209761_+	COG2378, COG2378, Predicted transcriptional regulator [Transcription]
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	7	6295356-6295930	6	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	ACGGTTGAACGGTCCGTTCAACCG	24	0	0	NA	NA	NA	11	11	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA,NA	NA|494aa|up_9|NC_013093.1_6286241_6287723_+	PRK13517, PRK13517, glutamate--cysteine ligase	NA|611aa|up_8|NC_013093.1_6287964_6289797_+	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system	NA|279aa|up_7|NC_013093.1_6290126_6290963_-	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily	NA|95aa|up_6|NC_013093.1_6291205_6291490_+	COG1733, COG1733, Predicted transcriptional regulators [Transcription]	NA|110aa|up_5|NC_013093.1_6291486_6291816_-	cd19534, E_NRPS, Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the Condensation-domain family	NA|136aa|up_4|NC_013093.1_6292019_6292427_-	cd17036, T3SC_YbjN-like_1, T110839 is structurally similar to type III secretion system chaperones and YbjN family proteins	NA|228aa|up_3|NC_013093.1_6292426_6293110_-	pfam06197, DUF998, Protein of unknown function (DUF998)	NA|191aa|up_2|NC_013093.1_6293170_6293743_-	PRK03759, PRK03759, isopentenyl-diphosphate Delta-isomerase	NA|190aa|up_1|NC_013093.1_6293797_6294367_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|283aa|up_0|NC_013093.1_6294443_6295292_+	pfam13649, Methyltransf_25, Methyltransferase domain	NA|296aa|down_0|NC_013093.1_6296165_6297053_-	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|310aa|down_1|NC_013093.1_6297233_6298163_+	pfam12852, Cupin_6, Cupin	NA|249aa|down_2|NC_013093.1_6298309_6299056_+	pfam14428, SCP1201-deam, SCP1	NA|139aa|down_3|NC_013093.1_6299043_6299460_+	pfam14430, Imm1, Immunity protein Imm1	NA|253aa|down_4|NC_013093.1_6299538_6300297_-	pfam18181, SLATT_1, SMODS and SLOG-associating 2TM effector domain 1	NA|408aa|down_5|NC_013093.1_6300293_6301517_-	pfam18171, LSDAT_prok, SLOG in TRPM, prokaryote	NA|487aa|down_6|NC_013093.1_6301594_6303055_+	PRK12825, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional	NA|1154aa|down_7|NC_013093.1_6303142_6306604_+	TIGR03491, TIGR03491, RecB family nuclease, putative, TM0106 family	NA|240aa|down_8|NC_013093.1_6307214_6307934_+	COG3889, COG3889, Predicted solute binding protein [General function prediction only]	NA|330aa|down_9|NC_013093.1_6308100_6309090_-	cd08234, threonine_DH_like, L-threonine dehydrogenase
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	8	6440070-6440219	7	CRISPRCasFinder	no	csa3	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Type I-A	TCCCGTTGCCGCGCAGCACCCTCG	24	1	2	6440094-6440111|6440094-6440111	NC_013093.1_5778358-5778341|NC_013093.1_3440984-3441001	NA	3	3	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|149aa|up_6|NC_013093.1_6429601_6430048_+,NA|79aa|down_3|NC_013093.1_6442997_6443234_-	NA|877aa|up_9|NC_013093.1_6424891_6427522_-	pfam12770, CHAT, CHAT domain	NA|405aa|up_8|NC_013093.1_6427590_6428805_+	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins	NA|220aa|up_7|NC_013093.1_6428967_6429627_+	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family	NA|149aa|up_6|NC_013093.1_6429601_6430048_+	NA	NA|652aa|up_5|NC_013093.1_6430566_6432522_+	COG2199, COG2199, c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]	NA|196aa|up_4|NC_013093.1_6432627_6433215_-	COG2229, COG2229, Predicted GTPase [General function prediction only]	NA|141aa|up_3|NC_013093.1_6433253_6433676_-	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]	NA|1061aa|up_2|NC_013093.1_6433672_6436855_-	pfam08376, NIT, Nitrate and nitrite sensing	NA|346aa|up_1|NC_013093.1_6437118_6438156_-	cd13652, PBP2_ThiY_THI5_like_1, Putative substrate binding domain of an ABC-type transporter similar to ThiY/THI5; the type 2 periplasmic binding protein fold	NA|401aa|up_0|NC_013093.1_6438346_6439549_+	PRK08243, PRK08243, 4-hydroxybenzoate 3-monooxygenase; Validated	NA|295aa|down_0|NC_013093.1_6440357_6441242_-	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters	NA|270aa|down_1|NC_013093.1_6441243_6442053_-	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]	NA|256aa|down_2|NC_013093.1_6442049_6442817_-	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]	NA|79aa|down_3|NC_013093.1_6442997_6443234_-	NA	NA|251aa|down_4|NC_013093.1_6443567_6444320_-	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]	NA|216aa|down_5|NC_013093.1_6444300_6444948_-	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB	NA|275aa|down_6|NC_013093.1_6444878_6445703_-	pfam02616, SMC_ScpA, Segregation and condensation protein ScpA	NA|323aa|down_7|NC_013093.1_6446376_6447345_-	pfam13614, AAA_31, AAA domain	csa3|117aa|down_8|NC_013093.1_6447437_6447788_-	COG0640, ArsR, Predicted transcriptional regulators [Transcription]	NA|336aa|down_9|NC_013093.1_6447934_6448942_-	PRK00283, xerD, tyrosine recombinase
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	9	6561020-6561119	8	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	GCTGCTGCACCACCGCGCTGGACC	24	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|207aa|up_3|NC_013093.1_6556596_6557217_-,NA|64aa|down_6|NC_013093.1_6567753_6567945_-	NA|328aa|up_9|NC_013093.1_6549462_6550446_+	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]	NA|724aa|up_8|NC_013093.1_6550511_6552683_-	PRK05298, PRK05298, excinuclease ABC subunit UvrB	NA|438aa|up_7|NC_013093.1_6552767_6554081_-	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated	NA|171aa|up_6|NC_013093.1_6554220_6554733_+	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]	NA|174aa|up_5|NC_013093.1_6554880_6555402_+	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]	NA|395aa|up_4|NC_013093.1_6555371_6556556_-	PRK03333, coaE, dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional	NA|207aa|up_3|NC_013093.1_6556596_6557217_-	NA	NA|496aa|up_2|NC_013093.1_6557512_6559000_-	PRK07899, rpsA, 30S ribosomal protein S1; Reviewed	NA|277aa|up_1|NC_013093.1_6559191_6560022_+	pfam13649, Methyltransf_25, Methyltransferase domain	NA|309aa|up_0|NC_013093.1_6560032_6560959_+	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate	NA|212aa|down_0|NC_013093.1_6561708_6562344_+	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system	NA|632aa|down_1|NC_013093.1_6562340_6564236_+	TIGR03062, hypothetical_protein_lp_1332, YhgE/Pip C-terminal domain	NA|216aa|down_2|NC_013093.1_6564196_6564844_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|206aa|down_3|NC_013093.1_6564889_6565507_-	PRK08309, PRK08309, short chain dehydrogenase; Provisional	NA|201aa|down_4|NC_013093.1_6565584_6566187_-	PRK08118, PRK08118, DNA topology modulation protein	NA|412aa|down_5|NC_013093.1_6566484_6567720_-	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only]	NA|64aa|down_6|NC_013093.1_6567753_6567945_-	NA	NA|889aa|down_7|NC_013093.1_6568950_6571617_-	PRK05755, PRK05755, DNA polymerase I; Provisional	NA|137aa|down_8|NC_013093.1_6571671_6572082_+	TIGR00369, Putative_esterase, uncharacterized domain 1	NA|167aa|down_9|NC_013093.1_6572104_6572605_+	pfam11611, DUF4352, Domain of unknown function (DUF4352)
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	10	6873360-6873467	9	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	GCCGCCGGGGCCTTGGGGGCCTGC	24	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA,NA|256aa|down_5|NC_013093.1_6877029_6877797_-	NA|90aa|up_9|NC_013093.1_6862076_6862346_-	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed	NA|154aa|up_8|NC_013093.1_6862471_6862933_-	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase	NA|160aa|up_7|NC_013093.1_6862929_6863409_-	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|311aa|up_6|NC_013093.1_6863509_6864442_-	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase	NA|279aa|up_5|NC_013093.1_6865055_6865892_-	PRK03287, truB, tRNA pseudouridine synthase B; Provisional	NA|440aa|up_4|NC_013093.1_6866027_6867347_-	cd06174, MFS, Major Facilitator Superfamily	NA|444aa|up_3|NC_013093.1_6867438_6868770_-	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins	NA|334aa|up_2|NC_013093.1_6868827_6869829_-	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only]	NA|150aa|up_1|NC_013093.1_6869848_6870298_-	PRK00521, rbfA, 30S ribosome-binding factor RbfA	NA|99aa|up_0|NC_013093.1_6870317_6870614_-	pfam04456, DUF503, Protein of unknown function (DUF503)	NA|119aa|down_0|NC_013093.1_6873891_6874248_-	pfam04296, DUF448, Protein of unknown function (DUF448)	NA|338aa|down_1|NC_013093.1_6874270_6875284_-	PRK12327, nusA, transcription elongation factor NusA; Provisional	NA|175aa|down_2|NC_013093.1_6875280_6875805_-	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed	NA|138aa|down_3|NC_013093.1_6875984_6876398_+	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional	NA|147aa|down_4|NC_013093.1_6876394_6876835_+	pfam14530, DUF4439, Domain of unknown function (DUF4439)	NA|256aa|down_5|NC_013093.1_6877029_6877797_-	NA	NA|334aa|down_6|NC_013093.1_6877984_6878986_-	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]	NA|263aa|down_7|NC_013093.1_6879087_6879876_-	PRK12748, PRK12748, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional	NA|136aa|down_8|NC_013093.1_6879924_6880332_+	pfam01894, UPF0047, Uncharacterized protein family UPF0047	NA|360aa|down_9|NC_013093.1_6880465_6881545_+	PRK14086, dnaA, chromosomal replication initiator protein DnaA
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	11	7290579-7290688	10	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	GTGTAGCCGGGGTTGTTGGTCGGGTTCGTGTAACCGGGGTT	41	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|179aa|up_6|NC_013093.1_7280457_7280994_+,NA|127aa|down_0|NC_013093.1_7291817_7292198_-	NA|324aa|up_9|NC_013093.1_7276483_7277455_+	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|494aa|up_8|NC_013093.1_7277555_7279037_+	pfam13777, DUF4173, Domain of unknown function (DUF4173)	NA|392aa|up_7|NC_013093.1_7279228_7280404_+	pfam00924, MS_channel, Mechanosensitive ion channel	NA|179aa|up_6|NC_013093.1_7280457_7280994_+	NA	NA|1080aa|up_5|NC_013093.1_7281701_7284941_+	cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, Peptidase S8 family domain in Tripeptidyl aminopeptidases_II	NA|552aa|up_4|NC_013093.1_7285108_7286764_+	PRK12834, PRK12834, putative FAD-binding dehydrogenase; Reviewed	NA|280aa|up_3|NC_013093.1_7286798_7287638_-	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional	NA|246aa|up_2|NC_013093.1_7287761_7288499_+	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only]	NA|159aa|up_1|NC_013093.1_7288502_7288979_-	smart00903, Flavin_Reduct, Flavin reductase like domain	NA|257aa|up_0|NC_013093.1_7289246_7290017_-	pfam14011, ESX-1_EspG, EspG family	NA|127aa|down_0|NC_013093.1_7291817_7292198_-	NA	NA|914aa|down_1|NC_013093.1_7292420_7295162_+	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain	NA|625aa|down_2|NC_013093.1_7295606_7297481_-	pfam13454, NAD_binding_9, FAD-NAD(P)-binding	NA|703aa|down_3|NC_013093.1_7298024_7300133_+	COG5001, COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]	NA|248aa|down_4|NC_013093.1_7300374_7301118_+	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family	NA|530aa|down_5|NC_013093.1_7301254_7302844_+	PRK11561, PRK11561, isovaleryl CoA dehydrogenase; Provisional	NA|254aa|down_6|NC_013093.1_7302840_7303602_+	PRK08259, PRK08259, crotonase/enoyl-CoA hydratase family protein	NA|384aa|down_7|NC_013093.1_7303969_7305121_-	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases	NA|644aa|down_8|NC_013093.1_7305126_7307058_-	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]	NA|534aa|down_9|NC_013093.1_7307057_7308659_-	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	12	7429938-7430045	11	CRISPRCasFinder	no	csa3	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Type I-A	ACCGCGCCGTCGCCGATCACCGCG	24	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA,NA|128aa|down_6|NC_013093.1_7436520_7436904_+	NA|65aa|up_9|NC_013093.1_7417031_7417226_-	COG2835, COG2835, Uncharacterized conserved protein [Function unknown]	NA|451aa|up_8|NC_013093.1_7417250_7418603_-	PRK09542, manB, phosphomannomutase/phosphoglucomutase; Reviewed	NA|120aa|up_7|NC_013093.1_7418681_7419041_-	pfam12005, DUF3499, Protein of unknown function (DUF3499)	NA|151aa|up_6|NC_013093.1_7419186_7419639_+	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria	NA|84aa|up_5|NC_013093.1_7424258_7424510_-	pfam02467, Whib, Transcription factor WhiB	NA|250aa|up_4|NC_013093.1_7424824_7425574_+	cd06158, S2P-M50_like_1, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms	NA|322aa|up_3|NC_013093.1_7425599_7426565_+	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional	NA|462aa|up_2|NC_013093.1_7426557_7427943_+	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional	NA|182aa|up_1|NC_013093.1_7427945_7428491_+	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X	NA|300aa|up_0|NC_013093.1_7428894_7429794_-	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]	NA|130aa|down_0|NC_013093.1_7431075_7431465_+	PHA03373, PHA03373, tegument protein; Provisional	NA|125aa|down_1|NC_013093.1_7431361_7431736_-	pfam00805, Pentapeptide, Pentapeptide repeats (8 copies)	NA|286aa|down_2|NC_013093.1_7431663_7432521_-	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only]	NA|378aa|down_3|NC_013093.1_7433069_7434203_-	cd03809, GT4_MtfB-like, glycosyltransferases MtfB, WbpX, and similar proteins	NA|355aa|down_4|NC_013093.1_7434376_7435441_-	cd03809, GT4_MtfB-like, glycosyltransferases MtfB, WbpX, and similar proteins	NA|301aa|down_5|NC_013093.1_7435586_7436489_+	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function	NA|128aa|down_6|NC_013093.1_7436520_7436904_+	NA	NA|831aa|down_7|NC_013093.1_7437008_7439501_+	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function	NA|365aa|down_8|NC_013093.1_7439493_7440588_+	cd03809, GT4_MtfB-like, glycosyltransferases MtfB, WbpX, and similar proteins	NA|297aa|down_9|NC_013093.1_7440993_7441884_-	pfam04321, RmlD_sub_bind, RmlD substrate binding domain
GCF_000023245.1_ASM2324v1	NC_013093	Actinosynnema mirum DSM 43827, complete sequence	13	7680691-7680800	12	CRISPRCasFinder	no		cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	Orphan	CGCCCTCACCCGATCGCCGGGGTGGGT	27	0	0	NA	NA	NA	1	1	Orphan	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e	NA|69aa|up_5|NC_013093.1_7675149_7675356_-,NA|266aa|down_6|NC_013093.1_7688021_7688819_-	NA|520aa|up_9|NC_013093.1_7669001_7670561_-	PRK00074, guaA, GMP synthase; Reviewed	NA|236aa|up_8|NC_013093.1_7670669_7671377_+	pfam01636, APH, Phosphotransferase enzyme family	NA|482aa|up_7|NC_013093.1_7671411_7672857_+	cd07147, ALDH_F21_RNP123, Aldehyde dehydrogenase family 21A1-like	NA|563aa|up_6|NC_013093.1_7673297_7674986_-	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]	NA|69aa|up_5|NC_013093.1_7675149_7675356_-	NA	NA|378aa|up_4|NC_013093.1_7675513_7676647_-	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein	NA|504aa|up_3|NC_013093.1_7676678_7678190_-	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed	NA|132aa|up_2|NC_013093.1_7678313_7678709_+	pfam17252, DUF5319, Family of unknown function (DUF5319)	NA|307aa|up_1|NC_013093.1_7678849_7679770_-	pfam16751, RsdA_SigD_bd, Anti-sigma-D factor RsdA to sigma factor binding region	NA|191aa|up_0|NC_013093.1_7679770_7680343_-	PRK09648, PRK09648, RNA polymerase sigma factor ShbA	NA|199aa|down_0|NC_013093.1_7681487_7682084_-	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|517aa|down_1|NC_013093.1_7682164_7683715_-	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau	NA|337aa|down_2|NC_013093.1_7683991_7685002_-	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA	NA|99aa|down_3|NC_013093.1_7685187_7685484_+	pfam02467, Whib, Transcription factor WhiB	NA|542aa|down_4|NC_013093.1_7685656_7687282_-	PRK12849, groEL, chaperonin GroEL; Reviewed	NA|98aa|down_5|NC_013093.1_7687366_7687660_-	PRK00364, groES, co-chaperonin GroES; Reviewed	NA|266aa|down_6|NC_013093.1_7688021_7688819_-	NA	NA|351aa|down_7|NC_013093.1_7689011_7690064_-	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	NA|148aa|down_8|NC_013093.1_7690056_7690500_-	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase	NA|233aa|down_9|NC_013093.1_7690511_7691210_-	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ
